-- dump date 20140619_000032 -- class Genbank::misc_feature -- table misc_feature_note -- id note 315730000001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730000002 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 315730000003 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 315730000004 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 315730000005 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730000006 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730000007 FtsX-like permease family; Region: FtsX; pfam02687 315730000008 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730000009 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730000010 Walker A/P-loop; other site 315730000011 ATP binding site [chemical binding]; other site 315730000012 Q-loop/lid; other site 315730000013 ABC transporter signature motif; other site 315730000014 Walker B; other site 315730000015 D-loop; other site 315730000016 H-loop/switch region; other site 315730000017 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730000018 MarR family; Region: MarR; pfam01047 315730000019 MarR family; Region: MarR_2; cl17246 315730000020 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730000021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730000022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730000023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730000024 dimerization interface [polypeptide binding]; other site 315730000025 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 315730000026 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 315730000027 S-methylmethionine transporter; Provisional; Region: PRK11387 315730000028 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 315730000029 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 315730000030 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 315730000031 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000032 amidase catalytic site [active] 315730000033 Zn binding residues [ion binding]; other site 315730000034 substrate binding site [chemical binding]; other site 315730000035 S-layer homology domain; Region: SLH; pfam00395 315730000036 S-layer homology domain; Region: SLH; pfam00395 315730000037 S-layer homology domain; Region: SLH; pfam00395 315730000038 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730000039 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 315730000040 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315730000041 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730000042 protein binding site [polypeptide binding]; other site 315730000043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730000045 dimerization interface [polypeptide binding]; other site 315730000046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000047 dimer interface [polypeptide binding]; other site 315730000048 phosphorylation site [posttranslational modification] 315730000049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000050 ATP binding site [chemical binding]; other site 315730000051 Mg2+ binding site [ion binding]; other site 315730000052 G-X-G motif; other site 315730000053 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 315730000054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000055 active site 315730000056 phosphorylation site [posttranslational modification] 315730000057 intermolecular recognition site; other site 315730000058 dimerization interface [polypeptide binding]; other site 315730000059 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000060 DNA binding site [nucleotide binding] 315730000061 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 315730000062 putative active site [active] 315730000063 putative catalytic triad [active] 315730000064 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 315730000065 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000066 Interdomain contacts; other site 315730000067 Cytokine receptor motif; other site 315730000068 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 315730000069 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 315730000070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000071 dimerization interface [polypeptide binding]; other site 315730000072 putative DNA binding site [nucleotide binding]; other site 315730000073 putative Zn2+ binding site [ion binding]; other site 315730000074 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 315730000075 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315730000076 catalytic residues [active] 315730000077 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730000078 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 315730000079 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315730000080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 315730000081 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 315730000082 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 315730000083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000084 catalytic residue [active] 315730000085 Condensation domain; Region: Condensation; pfam00668 315730000086 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000087 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000088 acyl-activating enzyme (AAE) consensus motif; other site 315730000089 AMP binding site [chemical binding]; other site 315730000090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000091 Condensation domain; Region: Condensation; pfam00668 315730000092 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000093 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000094 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000095 acyl-activating enzyme (AAE) consensus motif; other site 315730000096 AMP binding site [chemical binding]; other site 315730000097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000098 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 315730000099 putative NAD(P) binding site [chemical binding]; other site 315730000100 active site 315730000101 putative substrate binding site [chemical binding]; other site 315730000102 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730000103 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 315730000104 Walker A/P-loop; other site 315730000105 ATP binding site [chemical binding]; other site 315730000106 Q-loop/lid; other site 315730000107 ABC transporter signature motif; other site 315730000108 Walker B; other site 315730000109 D-loop; other site 315730000110 H-loop/switch region; other site 315730000111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730000112 TPR motif; other site 315730000113 binding surface 315730000114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730000115 TPR motif; other site 315730000116 binding surface 315730000117 putative acetyltransferase YhhY; Provisional; Region: PRK10140 315730000118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000119 Coenzyme A binding pocket [chemical binding]; other site 315730000120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730000121 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730000122 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730000123 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730000124 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 315730000125 VanW like protein; Region: VanW; pfam04294 315730000126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730000127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730000128 active site 315730000129 metal binding site [ion binding]; metal-binding site 315730000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 315730000131 Integrase core domain; Region: rve; pfam00665 315730000132 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 315730000133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000135 active site 315730000136 phosphorylation site [posttranslational modification] 315730000137 intermolecular recognition site; other site 315730000138 dimerization interface [polypeptide binding]; other site 315730000139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000140 DNA binding site [nucleotide binding] 315730000141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000142 HAMP domain; Region: HAMP; pfam00672 315730000143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000144 dimer interface [polypeptide binding]; other site 315730000145 phosphorylation site [posttranslational modification] 315730000146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000147 ATP binding site [chemical binding]; other site 315730000148 Mg2+ binding site [ion binding]; other site 315730000149 G-X-G motif; other site 315730000150 Electron transfer DM13; Region: DM13; pfam10517 315730000151 Uncharacterized conserved protein [Function unknown]; Region: COG5276 315730000152 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 315730000153 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 315730000154 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 315730000155 catalytic triad [active] 315730000156 catalytic triad [active] 315730000157 oxyanion hole [active] 315730000158 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 315730000159 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730000160 homotrimer interaction site [polypeptide binding]; other site 315730000161 putative active site [active] 315730000162 Recombination protein U; Region: RecU; pfam03838 315730000163 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730000164 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730000165 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 315730000166 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000167 active site 315730000168 DNA binding site [nucleotide binding] 315730000169 Int/Topo IB signature motif; other site 315730000170 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 315730000171 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000172 active site 315730000173 DNA binding site [nucleotide binding] 315730000174 Int/Topo IB signature motif; other site 315730000175 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730000176 catalytic residues [active] 315730000177 bacterial Hfq-like; Region: Hfq; cd01716 315730000178 hexamer interface [polypeptide binding]; other site 315730000179 Sm1 motif; other site 315730000180 RNA binding site [nucleotide binding]; other site 315730000181 Sm2 motif; other site 315730000182 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 315730000183 delta endotoxin; Region: Endotoxin_M; pfam00555 315730000184 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 315730000185 putative metal binding site [ion binding]; other site 315730000186 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 315730000187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730000188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730000189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730000190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730000191 dimerization interface [polypeptide binding]; other site 315730000192 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 315730000193 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 315730000194 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730000195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730000196 Walker A/P-loop; other site 315730000197 ATP binding site [chemical binding]; other site 315730000198 Q-loop/lid; other site 315730000199 ABC transporter signature motif; other site 315730000200 Walker B; other site 315730000201 D-loop; other site 315730000202 H-loop/switch region; other site 315730000203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730000204 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730000205 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730000206 Walker A/P-loop; other site 315730000207 ATP binding site [chemical binding]; other site 315730000208 Q-loop/lid; other site 315730000209 ABC transporter signature motif; other site 315730000210 Walker B; other site 315730000211 D-loop; other site 315730000212 H-loop/switch region; other site 315730000213 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 315730000214 NosL; Region: NosL; cl01769 315730000215 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 315730000216 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 315730000217 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 315730000218 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315730000219 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 315730000220 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730000221 trimer interface [polypeptide binding]; other site 315730000222 active site 315730000223 CoA binding site [chemical binding]; other site 315730000224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000225 dimerization interface [polypeptide binding]; other site 315730000226 putative DNA binding site [nucleotide binding]; other site 315730000227 putative Zn2+ binding site [ion binding]; other site 315730000228 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730000229 EamA-like transporter family; Region: EamA; pfam00892 315730000230 EamA-like transporter family; Region: EamA; pfam00892 315730000231 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 315730000232 classical (c) SDRs; Region: SDR_c; cd05233 315730000233 NAD(P) binding site [chemical binding]; other site 315730000234 active site 315730000235 Biofilm formation and stress response factor; Region: BsmA; pfam10014 315730000236 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 315730000237 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 315730000238 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 315730000239 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315730000240 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315730000241 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315730000242 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730000243 Spore germination protein; Region: Spore_permease; cl17796 315730000244 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730000245 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730000246 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730000247 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730000248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730000249 DNA binding residues [nucleotide binding] 315730000250 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 315730000251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730000253 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 315730000254 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 315730000255 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 315730000256 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 315730000257 PKC phosphorylation site [posttranslational modification]; other site 315730000258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000260 active site 315730000261 phosphorylation site [posttranslational modification] 315730000262 intermolecular recognition site; other site 315730000263 dimerization interface [polypeptide binding]; other site 315730000264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000265 DNA binding site [nucleotide binding] 315730000266 YrzO-like protein; Region: YrzO; pfam14142 315730000267 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730000268 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730000269 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730000270 NodB motif; other site 315730000271 active site 315730000272 catalytic site [active] 315730000273 Zn binding site [ion binding]; other site 315730000274 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730000275 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 315730000276 hexamer interface [polypeptide binding]; other site 315730000277 ligand binding site [chemical binding]; other site 315730000278 putative active site [active] 315730000279 NAD(P) binding site [chemical binding]; other site 315730000280 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315730000281 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315730000282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730000284 putative substrate translocation pore; other site 315730000285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730000287 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000288 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000289 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000290 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 315730000291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730000292 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000293 active site 315730000294 DNA binding site [nucleotide binding] 315730000295 Int/Topo IB signature motif; other site 315730000296 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000297 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000298 DNA binding residues [nucleotide binding] 315730000299 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 315730000300 DNA binding residues [nucleotide binding] 315730000301 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730000302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000303 dimerization interface [polypeptide binding]; other site 315730000304 putative DNA binding site [nucleotide binding]; other site 315730000305 putative Zn2+ binding site [ion binding]; other site 315730000306 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 315730000307 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730000308 FAD binding domain; Region: FAD_binding_4; pfam01565 315730000309 Berberine and berberine like; Region: BBE; pfam08031 315730000310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 315730000311 Integrase core domain; Region: rve; pfam00665 315730000312 Thioesterase domain; Region: Thioesterase; pfam00975 315730000313 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 315730000314 Condensation domain; Region: Condensation; pfam00668 315730000315 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000316 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000317 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000318 acyl-activating enzyme (AAE) consensus motif; other site 315730000319 AMP binding site [chemical binding]; other site 315730000320 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000321 peptide synthase; Provisional; Region: PRK12467 315730000322 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000323 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000324 acyl-activating enzyme (AAE) consensus motif; other site 315730000325 AMP binding site [chemical binding]; other site 315730000326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000327 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000328 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000329 acyl-activating enzyme (AAE) consensus motif; other site 315730000330 AMP binding site [chemical binding]; other site 315730000331 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000332 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730000333 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000334 acyl-activating enzyme (AAE) consensus motif; other site 315730000335 AMP binding site [chemical binding]; other site 315730000336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000337 Condensation domain; Region: Condensation; pfam00668 315730000338 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000339 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000340 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000341 acyl-activating enzyme (AAE) consensus motif; other site 315730000342 AMP binding site [chemical binding]; other site 315730000343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000344 Condensation domain; Region: Condensation; pfam00668 315730000345 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000346 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000347 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 315730000348 acyl-activating enzyme (AAE) consensus motif; other site 315730000349 AMP binding site [chemical binding]; other site 315730000350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000351 Condensation domain; Region: Condensation; pfam00668 315730000352 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000353 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000354 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730000355 acyl-activating enzyme (AAE) consensus motif; other site 315730000356 AMP binding site [chemical binding]; other site 315730000357 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730000358 Condensation domain; Region: Condensation; pfam00668 315730000359 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000360 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000362 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730000363 putative substrate translocation pore; other site 315730000364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 315730000365 Integrase core domain; Region: rve; pfam00665 315730000366 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 315730000367 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 315730000368 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000369 Interdomain contacts; other site 315730000370 Cytokine receptor motif; other site 315730000371 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 315730000372 Peptidase M60-like family; Region: M60-like; pfam13402 315730000373 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 315730000374 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000375 Interdomain contacts; other site 315730000376 Cytokine receptor motif; other site 315730000377 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 315730000378 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730000379 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730000380 catalytic residues [active] 315730000381 catalytic nucleophile [active] 315730000382 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730000383 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730000384 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730000385 Synaptic Site I dimer interface [polypeptide binding]; other site 315730000386 DNA binding site [nucleotide binding] 315730000387 bacterial Hfq-like; Region: Hfq; cd01716 315730000388 hexamer interface [polypeptide binding]; other site 315730000389 Sm1 motif; other site 315730000390 RNA binding site [nucleotide binding]; other site 315730000391 Sm2 motif; other site 315730000392 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730000393 active site 315730000394 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000395 YtxH-like protein; Region: YtxH; cl02079 315730000396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730000397 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730000398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000399 non-specific DNA binding site [nucleotide binding]; other site 315730000400 salt bridge; other site 315730000401 sequence-specific DNA binding site [nucleotide binding]; other site 315730000402 Transglycosylase; Region: Transgly; pfam00912 315730000403 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730000404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730000405 tetracycline repressor protein TetR; Provisional; Region: PRK13756 315730000406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730000407 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 315730000408 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730000409 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 315730000410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000411 non-specific DNA binding site [nucleotide binding]; other site 315730000412 salt bridge; other site 315730000413 sequence-specific DNA binding site [nucleotide binding]; other site 315730000414 Trp repressor protein; Region: Trp_repressor; cl17266 315730000415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730000416 DNA-binding site [nucleotide binding]; DNA binding site 315730000417 fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812 315730000418 FadR C-terminal domain; Region: FadR_C; pfam07840 315730000419 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 315730000420 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 315730000421 nucleotide binding site [chemical binding]; other site 315730000422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730000423 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000425 PAS fold; Region: PAS_4; pfam08448 315730000426 PAS domain S-box; Region: sensory_box; TIGR00229 315730000427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730000428 putative active site [active] 315730000429 heme pocket [chemical binding]; other site 315730000430 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730000431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730000432 putative active site [active] 315730000433 heme pocket [chemical binding]; other site 315730000434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000435 dimer interface [polypeptide binding]; other site 315730000436 phosphorylation site [posttranslational modification] 315730000437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000438 ATP binding site [chemical binding]; other site 315730000439 Mg2+ binding site [ion binding]; other site 315730000440 G-X-G motif; other site 315730000441 CAAX protease self-immunity; Region: Abi; pfam02517 315730000442 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315730000443 dimer interface [polypeptide binding]; other site 315730000444 FMN binding site [chemical binding]; other site 315730000445 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730000446 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730000447 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730000448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 315730000449 Integrase core domain; Region: rve; pfam00665 315730000450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730000451 DNA binding site [nucleotide binding] 315730000452 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315730000453 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730000454 Replication-relaxation; Region: Replic_Relax; pfam13814 315730000455 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315730000456 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730000457 catalytic residue [active] 315730000458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 315730000459 Integrase core domain; Region: rve; pfam00665 315730000460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 315730000461 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730000462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000463 Coenzyme A binding pocket [chemical binding]; other site 315730000464 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 315730000465 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730000466 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315730000467 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 315730000468 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315730000469 inhibitor-cofactor binding pocket; inhibition site 315730000470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730000471 catalytic residue [active] 315730000472 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730000473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000474 NAD(P) binding site [chemical binding]; other site 315730000475 active site 315730000476 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 315730000477 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730000478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000479 catalytic residue [active] 315730000480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 315730000481 WbqC-like protein family; Region: WbqC; pfam08889 315730000482 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 315730000483 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 315730000484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 315730000485 DNA interaction; other site 315730000486 Metal-binding active site; metal-binding site 315730000487 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730000488 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 315730000489 PA/protease or protease-like domain interface [polypeptide binding]; other site 315730000490 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 315730000491 Peptidase family M28; Region: Peptidase_M28; pfam04389 315730000492 metal binding site [ion binding]; metal-binding site 315730000493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730000495 putative substrate translocation pore; other site 315730000496 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730000497 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730000498 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 315730000499 putative active site [active] 315730000500 putative catalytic triad [active] 315730000501 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 315730000502 active site 315730000503 NTP binding site [chemical binding]; other site 315730000504 metal binding triad [ion binding]; metal-binding site 315730000505 antibiotic binding site [chemical binding]; other site 315730000506 Protein of unknown function DUF86; Region: DUF86; pfam01934 315730000507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730000509 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730000510 active site 315730000511 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730000512 dimer interface [polypeptide binding]; other site 315730000513 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730000514 Ligand Binding Site [chemical binding]; other site 315730000515 Molecular Tunnel; other site 315730000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730000518 Coenzyme A binding pocket [chemical binding]; other site 315730000519 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 315730000520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 315730000521 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 315730000522 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 315730000523 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730000524 IHF dimer interface [polypeptide binding]; other site 315730000525 IHF - DNA interface [nucleotide binding]; other site 315730000526 HD domain; Region: HD_4; pfam13328 315730000527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730000528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000529 salt bridge; other site 315730000530 non-specific DNA binding site [nucleotide binding]; other site 315730000531 sequence-specific DNA binding site [nucleotide binding]; other site 315730000532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730000533 TPR motif; other site 315730000534 binding surface 315730000535 YolD-like protein; Region: YolD; pfam08863 315730000536 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 315730000537 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315730000538 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 315730000539 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000540 amidase catalytic site [active] 315730000541 Zn binding residues [ion binding]; other site 315730000542 substrate binding site [chemical binding]; other site 315730000543 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730000544 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730000545 dimer interface [polypeptide binding]; other site 315730000546 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315730000547 ssDNA binding site [nucleotide binding]; other site 315730000548 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730000549 Phage lysis protein, holin; Region: Phage_holin; cl04675 315730000550 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 315730000551 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 315730000552 interdomain interaction site; other site 315730000553 nSec1 interaction sites; other site 315730000554 3D domain; Region: 3D; cl01439 315730000555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000557 active site 315730000558 phosphorylation site [posttranslational modification] 315730000559 intermolecular recognition site; other site 315730000560 dimerization interface [polypeptide binding]; other site 315730000561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000562 DNA binding site [nucleotide binding] 315730000563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000565 dimer interface [polypeptide binding]; other site 315730000566 phosphorylation site [posttranslational modification] 315730000567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000568 ATP binding site [chemical binding]; other site 315730000569 Mg2+ binding site [ion binding]; other site 315730000570 G-X-G motif; other site 315730000571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000573 dimer interface [polypeptide binding]; other site 315730000574 phosphorylation site [posttranslational modification] 315730000575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000576 ATP binding site [chemical binding]; other site 315730000577 Mg2+ binding site [ion binding]; other site 315730000578 G-X-G motif; other site 315730000579 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 315730000580 ATP synthase subunit C; Region: ATP-synt_C; cl00466 315730000581 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 315730000582 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315730000583 active site 315730000584 catalytic residues [active] 315730000585 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 315730000586 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 315730000587 thioester formation/cholesterol transfer; other site 315730000588 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 315730000589 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 315730000590 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 315730000591 Catalytic site; other site 315730000592 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 315730000593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315730000594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730000595 catalytic residue [active] 315730000596 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000597 amidase catalytic site [active] 315730000598 Zn binding residues [ion binding]; other site 315730000599 substrate binding site [chemical binding]; other site 315730000600 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730000601 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730000602 Baseplate J-like protein; Region: Baseplate_J; pfam04865 315730000603 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730000604 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 315730000605 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 315730000606 nudix motif; other site 315730000607 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 315730000608 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 315730000609 active site 315730000610 catalytic residues [active] 315730000611 DNA binding site [nucleotide binding] 315730000612 Int/Topo IB signature motif; other site 315730000613 Helix-turn-helix domain; Region: HTH_17; pfam12728 315730000614 Haemolysin XhlA; Region: XhlA; pfam10779 315730000615 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730000616 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730000617 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730000618 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730000619 YolD-like protein; Region: YolD; pfam08863 315730000620 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000621 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000622 DNA binding residues [nucleotide binding] 315730000623 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730000624 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730000625 peptide binding site [polypeptide binding]; other site 315730000626 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 315730000627 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000628 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000629 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000630 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315730000631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000632 P-loop; other site 315730000633 Magnesium ion binding site [ion binding]; other site 315730000634 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000635 Magnesium ion binding site [ion binding]; other site 315730000636 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 315730000637 multiple promoter invertase; Provisional; Region: mpi; PRK13413 315730000638 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730000639 catalytic residues [active] 315730000640 catalytic nucleophile [active] 315730000641 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730000642 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730000643 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730000644 Synaptic Site I dimer interface [polypeptide binding]; other site 315730000645 DNA binding site [nucleotide binding] 315730000646 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 315730000647 DNA-binding interface [nucleotide binding]; DNA binding site 315730000648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000649 putative DNA binding site [nucleotide binding]; other site 315730000650 dimerization interface [polypeptide binding]; other site 315730000651 putative Zn2+ binding site [ion binding]; other site 315730000652 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000654 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 315730000655 Toprim-like; Region: Toprim_2; pfam13155 315730000656 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 315730000657 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730000658 DNA topoisomerase III; Provisional; Region: PRK07726 315730000659 active site 315730000660 putative interdomain interaction site [polypeptide binding]; other site 315730000661 putative metal-binding site [ion binding]; other site 315730000662 putative nucleotide binding site [chemical binding]; other site 315730000663 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730000664 domain I; other site 315730000665 DNA binding groove [nucleotide binding] 315730000666 phosphate binding site [ion binding]; other site 315730000667 domain II; other site 315730000668 domain III; other site 315730000669 nucleotide binding site [chemical binding]; other site 315730000670 catalytic site [active] 315730000671 domain IV; other site 315730000672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730000673 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 315730000674 CAAX protease self-immunity; Region: Abi; pfam02517 315730000675 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 315730000676 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730000677 putative metal binding site; other site 315730000678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730000679 binding surface 315730000680 TPR motif; other site 315730000681 Initiator Replication protein; Region: Rep_3; pfam01051 315730000682 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 315730000683 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 315730000684 active site 315730000685 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730000686 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315730000687 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730000688 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315730000689 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730000690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000691 NAD(P) binding site [chemical binding]; other site 315730000692 active site 315730000693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730000694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730000695 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730000696 spore coat protein YutH; Region: spore_yutH; TIGR02905 315730000697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730000698 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730000699 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730000700 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730000701 active site 315730000702 ATP binding site [chemical binding]; other site 315730000703 spore coat protein YutH; Region: spore_yutH; TIGR02905 315730000704 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730000705 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730000706 DNA binding residues [nucleotide binding] 315730000707 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 315730000708 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 315730000709 3D domain; Region: 3D; cl01439 315730000710 thymidine kinase; Provisional; Region: PRK04296 315730000711 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730000712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000713 non-specific DNA binding site [nucleotide binding]; other site 315730000714 salt bridge; other site 315730000715 sequence-specific DNA binding site [nucleotide binding]; other site 315730000716 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730000717 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730000718 Nucleoside recognition; Region: Gate; pfam07670 315730000719 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730000720 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000721 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000722 Substrate-binding site [chemical binding]; other site 315730000723 Substrate specificity [chemical binding]; other site 315730000724 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 315730000725 active site 315730000726 putative DNA-binding cleft [nucleotide binding]; other site 315730000727 dimer interface [polypeptide binding]; other site 315730000728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730000729 active site 315730000730 catalytic site [active] 315730000731 substrate binding site [chemical binding]; other site 315730000732 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 315730000733 catalytic site [active] 315730000734 nitrosocyanin; Region: nitroso_cyanin; TIGR03096 315730000735 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 315730000736 active site 315730000737 catalytic site [active] 315730000738 substrate binding site [chemical binding]; other site 315730000739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000740 non-specific DNA binding site [nucleotide binding]; other site 315730000741 salt bridge; other site 315730000742 sequence-specific DNA binding site [nucleotide binding]; other site 315730000743 Toprim-like; Region: Toprim_2; pfam13155 315730000744 active site 315730000745 metal binding site [ion binding]; metal-binding site 315730000746 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 315730000747 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 315730000748 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 315730000749 Walker A motif; other site 315730000750 ATP binding site [chemical binding]; other site 315730000751 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 315730000752 Ligand Binding Site [chemical binding]; other site 315730000753 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 315730000754 Walker A motif; other site 315730000755 ATP binding site [chemical binding]; other site 315730000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 315730000757 Walker B motif; other site 315730000758 arginine finger; other site 315730000759 Helix-turn-helix domain; Region: HTH_36; pfam13730 315730000760 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 315730000761 Mg binding site [ion binding]; other site 315730000762 nucleotide binding site [chemical binding]; other site 315730000763 putative protofilament interface [polypeptide binding]; other site 315730000764 Helix-turn-helix domain; Region: HTH_36; pfam13730 315730000765 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 315730000766 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730000767 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730000768 active site 315730000769 metal binding site [ion binding]; metal-binding site 315730000770 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730000771 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 315730000772 Phage tail protein; Region: Sipho_tail; pfam05709 315730000773 Phage tail protein; Region: Sipho_tail; cl17486 315730000774 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 315730000775 Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432 315730000776 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 315730000777 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 315730000778 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 315730000779 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 315730000780 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 315730000781 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 315730000782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000783 active site 315730000784 DNA binding site [nucleotide binding] 315730000785 Int/Topo IB signature motif; other site 315730000786 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315730000787 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 315730000788 cofactor binding site; other site 315730000789 DNA binding site [nucleotide binding] 315730000790 substrate interaction site [chemical binding]; other site 315730000791 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315730000792 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730000793 GIY-YIG motif/motif A; other site 315730000794 active site 315730000795 catalytic site [active] 315730000796 putative DNA binding site [nucleotide binding]; other site 315730000797 metal binding site [ion binding]; metal-binding site 315730000798 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 315730000799 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 315730000800 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315730000801 active site 315730000802 catalytic site [active] 315730000803 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 315730000804 Domain of unknown function (DUF955); Region: DUF955; cl01076 315730000805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000806 non-specific DNA binding site [nucleotide binding]; other site 315730000807 salt bridge; other site 315730000808 sequence-specific DNA binding site [nucleotide binding]; other site 315730000809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 315730000810 non-specific DNA binding site [nucleotide binding]; other site 315730000811 salt bridge; other site 315730000812 sequence-specific DNA binding site [nucleotide binding]; other site 315730000813 Prophage antirepressor [Transcription]; Region: COG3617 315730000814 BRO family, N-terminal domain; Region: Bro-N; smart01040 315730000815 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 315730000816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000817 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730000818 Walker A motif; other site 315730000819 ATP binding site [chemical binding]; other site 315730000820 Walker B motif; other site 315730000821 arginine finger; other site 315730000822 Recombination protein U; Region: RecU; pfam03838 315730000823 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730000824 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730000825 Phage portal protein; Region: Phage_portal; pfam04860 315730000826 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730000827 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 315730000828 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 315730000829 Phage capsid family; Region: Phage_capsid; pfam05065 315730000830 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 315730000831 oligomerization interface [polypeptide binding]; other site 315730000832 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 315730000833 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730000834 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730000835 Phage-related protein [Function unknown]; Region: COG5412 315730000836 Phage tail protein; Region: Sipho_tail; pfam05709 315730000837 Phage tail protein; Region: Sipho_tail; cl17486 315730000838 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730000839 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 315730000840 Holin family; Region: Phage_holin_4; pfam05105 315730000841 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000842 amidase catalytic site [active] 315730000843 Zn binding residues [ion binding]; other site 315730000844 substrate binding site [chemical binding]; other site 315730000845 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730000846 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730000847 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730000848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000849 non-specific DNA binding site [nucleotide binding]; other site 315730000850 salt bridge; other site 315730000851 sequence-specific DNA binding site [nucleotide binding]; other site 315730000852 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730000853 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315730000854 Replication-relaxation; Region: Replic_Relax; pfam13814 315730000855 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000857 DNA binding residues [nucleotide binding] 315730000858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000859 non-specific DNA binding site [nucleotide binding]; other site 315730000860 salt bridge; other site 315730000861 sequence-specific DNA binding site [nucleotide binding]; other site 315730000862 Protein of unknown function DUF91; Region: DUF91; cl00709 315730000863 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 315730000864 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000865 AAA domain; Region: AAA_31; pfam13614 315730000866 P-loop; other site 315730000867 Magnesium ion binding site [ion binding]; other site 315730000868 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000869 Magnesium ion binding site [ion binding]; other site 315730000870 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 315730000871 DnaA N-terminal domain; Region: DnaA_N; pfam11638 315730000872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000873 Walker A motif; other site 315730000874 ATP binding site [chemical binding]; other site 315730000875 Walker B motif; other site 315730000876 arginine finger; other site 315730000877 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 315730000878 DnaA box-binding interface [nucleotide binding]; other site 315730000879 DNA polymerase III subunit beta; Validated; Region: PRK05643 315730000880 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315730000881 putative DNA binding surface [nucleotide binding]; other site 315730000882 dimer interface [polypeptide binding]; other site 315730000883 beta-clamp/clamp loader binding surface; other site 315730000884 beta-clamp/translesion DNA polymerase binding surface; other site 315730000885 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 315730000886 recombination protein F; Reviewed; Region: recF; PRK00064 315730000887 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 315730000888 Walker A/P-loop; other site 315730000889 ATP binding site [chemical binding]; other site 315730000890 Q-loop/lid; other site 315730000891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730000892 ABC transporter signature motif; other site 315730000893 Walker B; other site 315730000894 D-loop; other site 315730000895 H-loop/switch region; other site 315730000896 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 315730000897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000898 Mg2+ binding site [ion binding]; other site 315730000899 G-X-G motif; other site 315730000900 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315730000901 anchoring element; other site 315730000902 dimer interface [polypeptide binding]; other site 315730000903 ATP binding site [chemical binding]; other site 315730000904 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315730000905 active site 315730000906 putative metal-binding site [ion binding]; other site 315730000907 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315730000908 DNA gyrase subunit A; Validated; Region: PRK05560 315730000909 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 315730000910 CAP-like domain; other site 315730000911 active site 315730000912 primary dimer interface [polypeptide binding]; other site 315730000913 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000914 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000915 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000916 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000917 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000918 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000919 YaaC-like Protein; Region: YaaC; pfam14175 315730000920 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 315730000921 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 315730000922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 315730000923 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 315730000924 active site 315730000925 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730000926 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730000927 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 315730000928 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 315730000929 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 315730000930 active site 315730000931 multimer interface [polypeptide binding]; other site 315730000932 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 315730000933 predicted active site [active] 315730000934 catalytic triad [active] 315730000935 seryl-tRNA synthetase; Provisional; Region: PRK05431 315730000936 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730000937 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 315730000938 dimer interface [polypeptide binding]; other site 315730000939 active site 315730000940 motif 1; other site 315730000941 motif 2; other site 315730000942 motif 3; other site 315730000943 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 315730000944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 315730000945 DNA binding residues [nucleotide binding] 315730000946 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000947 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000948 Substrate-binding site [chemical binding]; other site 315730000949 Substrate specificity [chemical binding]; other site 315730000950 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000951 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000952 Substrate-binding site [chemical binding]; other site 315730000953 Substrate specificity [chemical binding]; other site 315730000954 Isochorismatase family; Region: Isochorismatase; pfam00857 315730000955 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315730000956 catalytic triad [active] 315730000957 conserved cis-peptide bond; other site 315730000958 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315730000959 nucleoside/Zn binding site; other site 315730000960 dimer interface [polypeptide binding]; other site 315730000961 catalytic motif [active] 315730000962 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 315730000963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000964 Walker A motif; other site 315730000965 ATP binding site [chemical binding]; other site 315730000966 Walker B motif; other site 315730000967 arginine finger; other site 315730000968 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 315730000969 hypothetical protein; Validated; Region: PRK00153 315730000970 recombination protein RecR; Reviewed; Region: recR; PRK00076 315730000971 RecR protein; Region: RecR; pfam02132 315730000972 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 315730000973 putative active site [active] 315730000974 putative metal-binding site [ion binding]; other site 315730000975 tetramer interface [polypeptide binding]; other site 315730000976 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 315730000977 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 315730000978 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 315730000979 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315730000980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730000981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000982 catalytic residue [active] 315730000983 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315730000984 thymidylate kinase; Validated; Region: tmk; PRK00698 315730000985 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 315730000986 TMP-binding site; other site 315730000987 ATP-binding site [chemical binding]; other site 315730000988 DNA polymerase III subunit delta'; Validated; Region: PRK08058 315730000989 DNA polymerase III subunit delta'; Validated; Region: PRK08485 315730000990 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 315730000991 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 315730000992 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 315730000993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730000994 S-adenosylmethionine binding site [chemical binding]; other site 315730000995 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 315730000996 GIY-YIG motif/motif A; other site 315730000997 putative active site [active] 315730000998 putative metal binding site [ion binding]; other site 315730000999 Predicted methyltransferases [General function prediction only]; Region: COG0313 315730001000 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 315730001001 putative SAM binding site [chemical binding]; other site 315730001002 putative homodimer interface [polypeptide binding]; other site 315730001003 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315730001004 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315730001005 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 315730001006 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315730001007 active site 315730001008 HIGH motif; other site 315730001009 KMSKS motif; other site 315730001010 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315730001011 tRNA binding surface [nucleotide binding]; other site 315730001012 anticodon binding site; other site 315730001013 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 315730001014 dimer interface [polypeptide binding]; other site 315730001015 putative tRNA-binding site [nucleotide binding]; other site 315730001016 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 315730001017 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315730001018 active site 315730001019 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 315730001020 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315730001021 putative active site [active] 315730001022 putative metal binding site [ion binding]; other site 315730001023 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 315730001024 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 315730001025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001026 S-adenosylmethionine binding site [chemical binding]; other site 315730001027 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 315730001028 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 315730001029 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730001030 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 315730001031 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315730001032 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315730001033 pur operon repressor; Provisional; Region: PRK09213 315730001034 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 315730001035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001036 active site 315730001037 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730001038 homotrimer interaction site [polypeptide binding]; other site 315730001039 putative active site [active] 315730001040 regulatory protein SpoVG; Reviewed; Region: PRK13259 315730001041 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 315730001042 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 315730001043 Substrate binding site; other site 315730001044 Mg++ binding site; other site 315730001045 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 315730001046 active site 315730001047 substrate binding site [chemical binding]; other site 315730001048 CoA binding site [chemical binding]; other site 315730001049 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 315730001050 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 315730001051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001052 active site 315730001053 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 315730001054 putative active site [active] 315730001055 catalytic residue [active] 315730001056 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 315730001057 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 315730001058 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 315730001059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730001060 ATP binding site [chemical binding]; other site 315730001061 putative Mg++ binding site [ion binding]; other site 315730001062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730001063 nucleotide binding region [chemical binding]; other site 315730001064 ATP-binding site [chemical binding]; other site 315730001065 TRCF domain; Region: TRCF; pfam03461 315730001066 stage V sporulation protein T; Region: spore_V_T; TIGR02851 315730001067 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 315730001068 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730001069 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 315730001070 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 315730001071 putative SAM binding site [chemical binding]; other site 315730001072 putative homodimer interface [polypeptide binding]; other site 315730001073 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 315730001074 homodimer interface [polypeptide binding]; other site 315730001075 metal binding site [ion binding]; metal-binding site 315730001076 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 315730001077 homodimer interface [polypeptide binding]; other site 315730001078 active site 315730001079 putative chemical substrate binding site [chemical binding]; other site 315730001080 metal binding site [ion binding]; metal-binding site 315730001081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730001082 RNA binding surface [nucleotide binding]; other site 315730001083 sporulation protein YabP; Region: spore_yabP; TIGR02892 315730001084 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 315730001085 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 315730001086 Septum formation initiator; Region: DivIC; pfam04977 315730001087 hypothetical protein; Provisional; Region: PRK08582 315730001088 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 315730001089 RNA binding site [nucleotide binding]; other site 315730001090 stage II sporulation protein E; Region: spore_II_E; TIGR02865 315730001091 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 315730001092 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 315730001093 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 315730001094 Ligand Binding Site [chemical binding]; other site 315730001095 TilS substrate binding domain; Region: TilS; pfam09179 315730001096 TilS substrate C-terminal domain; Region: TilS_C; smart00977 315730001097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001098 active site 315730001099 FtsH Extracellular; Region: FtsH_ext; pfam06480 315730001100 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 315730001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001102 Walker A motif; other site 315730001103 ATP binding site [chemical binding]; other site 315730001104 Walker B motif; other site 315730001105 arginine finger; other site 315730001106 Peptidase family M41; Region: Peptidase_M41; pfam01434 315730001107 pantothenate kinase; Reviewed; Region: PRK13318 315730001108 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 315730001109 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 315730001110 dimerization interface [polypeptide binding]; other site 315730001111 domain crossover interface; other site 315730001112 redox-dependent activation switch; other site 315730001113 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730001114 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730001115 dimer interface [polypeptide binding]; other site 315730001116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001117 catalytic residue [active] 315730001118 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 315730001119 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315730001120 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 315730001121 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315730001122 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315730001123 glutamine binding [chemical binding]; other site 315730001124 catalytic triad [active] 315730001125 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315730001126 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 315730001127 homodimer interface [polypeptide binding]; other site 315730001128 substrate-cofactor binding pocket; other site 315730001129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001130 catalytic residue [active] 315730001131 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 315730001132 dihydropteroate synthase; Region: DHPS; TIGR01496 315730001133 substrate binding pocket [chemical binding]; other site 315730001134 dimer interface [polypeptide binding]; other site 315730001135 inhibitor binding site; inhibition site 315730001136 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 315730001137 homooctamer interface [polypeptide binding]; other site 315730001138 active site 315730001139 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 315730001140 catalytic center binding site [active] 315730001141 ATP binding site [chemical binding]; other site 315730001142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730001143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730001144 non-specific DNA binding site [nucleotide binding]; other site 315730001145 salt bridge; other site 315730001146 sequence-specific DNA binding site [nucleotide binding]; other site 315730001147 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 315730001148 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315730001149 FMN binding site [chemical binding]; other site 315730001150 active site 315730001151 catalytic residues [active] 315730001152 substrate binding site [chemical binding]; other site 315730001153 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 315730001154 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 315730001155 dimer interface [polypeptide binding]; other site 315730001156 putative anticodon binding site; other site 315730001157 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 315730001158 motif 1; other site 315730001159 active site 315730001160 motif 2; other site 315730001161 motif 3; other site 315730001162 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 315730001163 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 315730001164 UvrB/uvrC motif; Region: UVR; pfam02151 315730001165 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 315730001166 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 315730001167 ADP binding site [chemical binding]; other site 315730001168 phosphagen binding site; other site 315730001169 substrate specificity loop; other site 315730001170 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 315730001171 Clp amino terminal domain; Region: Clp_N; pfam02861 315730001172 Clp amino terminal domain; Region: Clp_N; pfam02861 315730001173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001174 Walker A motif; other site 315730001175 ATP binding site [chemical binding]; other site 315730001176 Walker B motif; other site 315730001177 arginine finger; other site 315730001178 UvrB/uvrC motif; Region: UVR; pfam02151 315730001179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001180 Walker A motif; other site 315730001181 ATP binding site [chemical binding]; other site 315730001182 Walker B motif; other site 315730001183 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315730001184 DNA repair protein RadA; Provisional; Region: PRK11823 315730001185 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 315730001186 Walker A motif/ATP binding site; other site 315730001187 ATP binding site [chemical binding]; other site 315730001188 Walker B motif; other site 315730001189 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 315730001190 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 315730001191 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730001192 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 315730001193 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 315730001194 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 315730001195 putative active site [active] 315730001196 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 315730001197 substrate binding site; other site 315730001198 dimer interface; other site 315730001199 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 315730001200 homotrimer interaction site [polypeptide binding]; other site 315730001201 zinc binding site [ion binding]; other site 315730001202 CDP-binding sites; other site 315730001203 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 315730001204 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315730001205 HIGH motif; other site 315730001206 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315730001207 active site 315730001208 KMSKS motif; other site 315730001209 serine O-acetyltransferase; Region: cysE; TIGR01172 315730001210 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 315730001211 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315730001212 trimer interface [polypeptide binding]; other site 315730001213 active site 315730001214 substrate binding site [chemical binding]; other site 315730001215 CoA binding site [chemical binding]; other site 315730001216 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 315730001217 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315730001218 active site 315730001219 HIGH motif; other site 315730001220 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315730001221 KMSKS motif; other site 315730001222 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315730001223 tRNA binding surface [nucleotide binding]; other site 315730001224 anticodon binding site; other site 315730001225 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 315730001226 active site 315730001227 metal binding site [ion binding]; metal-binding site 315730001228 dimerization interface [polypeptide binding]; other site 315730001229 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 315730001230 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 315730001231 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 315730001232 YacP-like NYN domain; Region: NYN_YacP; pfam05991 315730001233 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 315730001234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730001235 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730001236 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 315730001237 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 315730001238 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 315730001239 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 315730001240 putative homodimer interface [polypeptide binding]; other site 315730001241 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 315730001242 heterodimer interface [polypeptide binding]; other site 315730001243 homodimer interface [polypeptide binding]; other site 315730001244 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 315730001245 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 315730001246 23S rRNA interface [nucleotide binding]; other site 315730001247 L7/L12 interface [polypeptide binding]; other site 315730001248 putative thiostrepton binding site; other site 315730001249 L25 interface [polypeptide binding]; other site 315730001250 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 315730001251 mRNA/rRNA interface [nucleotide binding]; other site 315730001252 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 315730001253 23S rRNA interface [nucleotide binding]; other site 315730001254 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 315730001255 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 315730001256 core dimer interface [polypeptide binding]; other site 315730001257 peripheral dimer interface [polypeptide binding]; other site 315730001258 L10 interface [polypeptide binding]; other site 315730001259 L11 interface [polypeptide binding]; other site 315730001260 putative EF-Tu interaction site [polypeptide binding]; other site 315730001261 putative EF-G interaction site [polypeptide binding]; other site 315730001262 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 315730001263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001264 S-adenosylmethionine binding site [chemical binding]; other site 315730001265 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 315730001266 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315730001267 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 315730001268 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315730001269 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 315730001270 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 315730001271 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 315730001272 RPB10 interaction site [polypeptide binding]; other site 315730001273 RPB1 interaction site [polypeptide binding]; other site 315730001274 RPB11 interaction site [polypeptide binding]; other site 315730001275 RPB3 interaction site [polypeptide binding]; other site 315730001276 RPB12 interaction site [polypeptide binding]; other site 315730001277 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 315730001278 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 315730001279 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 315730001280 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 315730001281 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 315730001282 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315730001283 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 315730001284 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 315730001285 G-loop; other site 315730001286 DNA binding site [nucleotide binding] 315730001287 hypothetical protein; Provisional; Region: PRK06683 315730001288 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 315730001289 S17 interaction site [polypeptide binding]; other site 315730001290 S8 interaction site; other site 315730001291 16S rRNA interaction site [nucleotide binding]; other site 315730001292 streptomycin interaction site [chemical binding]; other site 315730001293 23S rRNA interaction site [nucleotide binding]; other site 315730001294 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 315730001295 30S ribosomal protein S7; Validated; Region: PRK05302 315730001296 elongation factor G; Reviewed; Region: PRK00007 315730001297 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 315730001298 G1 box; other site 315730001299 putative GEF interaction site [polypeptide binding]; other site 315730001300 GTP/Mg2+ binding site [chemical binding]; other site 315730001301 Switch I region; other site 315730001302 G2 box; other site 315730001303 G3 box; other site 315730001304 Switch II region; other site 315730001305 G4 box; other site 315730001306 G5 box; other site 315730001307 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 315730001308 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 315730001309 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 315730001310 elongation factor Tu; Reviewed; Region: PRK00049 315730001311 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 315730001312 G1 box; other site 315730001313 GEF interaction site [polypeptide binding]; other site 315730001314 GTP/Mg2+ binding site [chemical binding]; other site 315730001315 Switch I region; other site 315730001316 G2 box; other site 315730001317 G3 box; other site 315730001318 Switch II region; other site 315730001319 G4 box; other site 315730001320 G5 box; other site 315730001321 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 315730001322 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 315730001323 Antibiotic Binding Site [chemical binding]; other site 315730001324 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 315730001325 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 315730001326 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 315730001327 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 315730001328 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 315730001329 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 315730001330 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 315730001331 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 315730001332 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 315730001333 putative translocon binding site; other site 315730001334 protein-rRNA interface [nucleotide binding]; other site 315730001335 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 315730001336 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 315730001337 G-X-X-G motif; other site 315730001338 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 315730001339 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 315730001340 23S rRNA interface [nucleotide binding]; other site 315730001341 5S rRNA interface [nucleotide binding]; other site 315730001342 putative antibiotic binding site [chemical binding]; other site 315730001343 L25 interface [polypeptide binding]; other site 315730001344 L27 interface [polypeptide binding]; other site 315730001345 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 315730001346 23S rRNA interface [nucleotide binding]; other site 315730001347 putative translocon interaction site; other site 315730001348 signal recognition particle (SRP54) interaction site; other site 315730001349 L23 interface [polypeptide binding]; other site 315730001350 trigger factor interaction site; other site 315730001351 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 315730001352 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 315730001353 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 315730001354 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 315730001355 RNA binding site [nucleotide binding]; other site 315730001356 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 315730001357 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 315730001358 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 315730001359 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 315730001360 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 315730001361 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 315730001362 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315730001363 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315730001364 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 315730001365 5S rRNA interface [nucleotide binding]; other site 315730001366 L27 interface [polypeptide binding]; other site 315730001367 23S rRNA interface [nucleotide binding]; other site 315730001368 L5 interface [polypeptide binding]; other site 315730001369 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 315730001370 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 315730001371 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 315730001372 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 315730001373 23S rRNA binding site [nucleotide binding]; other site 315730001374 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 315730001375 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 315730001376 SecY translocase; Region: SecY; pfam00344 315730001377 adenylate kinase; Reviewed; Region: adk; PRK00279 315730001378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 315730001379 AMP-binding site [chemical binding]; other site 315730001380 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 315730001381 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730001382 active site 315730001383 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 315730001384 rRNA binding site [nucleotide binding]; other site 315730001385 predicted 30S ribosome binding site; other site 315730001386 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 315730001387 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 315730001388 30S ribosomal protein S13; Region: bact_S13; TIGR03631 315730001389 30S ribosomal protein S11; Validated; Region: PRK05309 315730001390 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 315730001391 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 315730001392 alphaNTD - beta interaction site [polypeptide binding]; other site 315730001393 alphaNTD homodimer interface [polypeptide binding]; other site 315730001394 alphaNTD - beta' interaction site [polypeptide binding]; other site 315730001395 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 315730001396 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 315730001397 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 315730001398 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315730001399 Walker A/P-loop; other site 315730001400 ATP binding site [chemical binding]; other site 315730001401 Q-loop/lid; other site 315730001402 ABC transporter signature motif; other site 315730001403 Walker B; other site 315730001404 D-loop; other site 315730001405 H-loop/switch region; other site 315730001406 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 315730001407 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315730001408 Walker A/P-loop; other site 315730001409 ATP binding site [chemical binding]; other site 315730001410 Q-loop/lid; other site 315730001411 ABC transporter signature motif; other site 315730001412 Walker B; other site 315730001413 D-loop; other site 315730001414 H-loop/switch region; other site 315730001415 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315730001416 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 315730001417 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 315730001418 dimerization interface 3.5A [polypeptide binding]; other site 315730001419 active site 315730001420 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 315730001421 23S rRNA interface [nucleotide binding]; other site 315730001422 L3 interface [polypeptide binding]; other site 315730001423 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 315730001424 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 315730001425 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730001426 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730001427 active site 315730001428 metal binding site [ion binding]; metal-binding site 315730001429 Domain of unknown function DUF59; Region: DUF59; cl00941 315730001430 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 315730001431 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 315730001432 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 315730001433 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730001434 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 315730001435 NodB motif; other site 315730001436 putative active site [active] 315730001437 putative catalytic site [active] 315730001438 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 315730001439 Arginase family; Region: Arginase; cd09989 315730001440 agmatinase; Region: agmatinase; TIGR01230 315730001441 active site 315730001442 Mn binding site [ion binding]; other site 315730001443 oligomer interface [polypeptide binding]; other site 315730001444 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315730001445 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730001446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 315730001447 YbbR-like protein; Region: YbbR; pfam07949 315730001448 YbbR-like protein; Region: YbbR; pfam07949 315730001449 YbbR-like protein; Region: YbbR; pfam07949 315730001450 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 315730001451 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 315730001452 active site 315730001453 substrate binding site [chemical binding]; other site 315730001454 metal binding site [ion binding]; metal-binding site 315730001455 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 315730001456 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 315730001457 glutaminase active site [active] 315730001458 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 315730001459 dimer interface [polypeptide binding]; other site 315730001460 active site 315730001461 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 315730001462 dimer interface [polypeptide binding]; other site 315730001463 active site 315730001464 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 315730001465 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730001466 Predicted membrane protein [Function unknown]; Region: COG2259 315730001467 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730001468 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730001469 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 315730001470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730001471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730001472 DNA binding residues [nucleotide binding] 315730001473 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 315730001474 classical (c) SDRs; Region: SDR_c; cd05233 315730001475 NAD(P) binding site [chemical binding]; other site 315730001476 active site 315730001477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001478 dimer interface [polypeptide binding]; other site 315730001479 conserved gate region; other site 315730001480 ABC-ATPase subunit interface; other site 315730001481 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315730001482 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 315730001483 Walker A/P-loop; other site 315730001484 ATP binding site [chemical binding]; other site 315730001485 Q-loop/lid; other site 315730001486 ABC transporter signature motif; other site 315730001487 Walker B; other site 315730001488 D-loop; other site 315730001489 H-loop/switch region; other site 315730001490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001491 NIL domain; Region: NIL; pfam09383 315730001492 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 315730001493 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 315730001494 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730001495 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 315730001496 putative NAD(P) binding site [chemical binding]; other site 315730001497 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730001498 FAD binding domain; Region: FAD_binding_4; pfam01565 315730001499 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 315730001500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730001501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001502 putative substrate translocation pore; other site 315730001503 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 315730001504 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315730001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001506 putative substrate translocation pore; other site 315730001507 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 315730001508 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 315730001509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001511 dimer interface [polypeptide binding]; other site 315730001512 conserved gate region; other site 315730001513 putative PBP binding loops; other site 315730001514 ABC-ATPase subunit interface; other site 315730001515 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730001516 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730001517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001518 dimer interface [polypeptide binding]; other site 315730001519 conserved gate region; other site 315730001520 putative PBP binding loops; other site 315730001521 ABC-ATPase subunit interface; other site 315730001522 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730001523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730001524 Walker A/P-loop; other site 315730001525 ATP binding site [chemical binding]; other site 315730001526 Q-loop/lid; other site 315730001527 ABC transporter signature motif; other site 315730001528 Walker B; other site 315730001529 D-loop; other site 315730001530 H-loop/switch region; other site 315730001531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001532 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315730001533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730001534 Walker A/P-loop; other site 315730001535 ATP binding site [chemical binding]; other site 315730001536 Q-loop/lid; other site 315730001537 ABC transporter signature motif; other site 315730001538 Walker B; other site 315730001539 D-loop; other site 315730001540 H-loop/switch region; other site 315730001541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001542 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001543 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001544 peptide binding site [polypeptide binding]; other site 315730001545 YusW-like protein; Region: YusW; pfam14039 315730001546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730001547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730001548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730001549 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001550 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001551 peptide binding site [polypeptide binding]; other site 315730001552 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001553 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001554 peptide binding site [polypeptide binding]; other site 315730001555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730001556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730001557 active site 315730001558 catalytic tetrad [active] 315730001559 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 315730001560 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315730001561 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 315730001562 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 315730001563 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 315730001564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001565 dimer interface [polypeptide binding]; other site 315730001566 conserved gate region; other site 315730001567 putative PBP binding loops; other site 315730001568 ABC-ATPase subunit interface; other site 315730001569 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730001570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315730001571 DNA binding domain, excisionase family; Region: excise; TIGR01764 315730001572 PBP superfamily domain; Region: PBP_like; pfam12727 315730001573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730001574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730001575 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 315730001576 putative dimerization interface [polypeptide binding]; other site 315730001577 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730001578 EamA-like transporter family; Region: EamA; pfam00892 315730001579 YrzO-like protein; Region: YrzO; pfam14142 315730001580 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 315730001581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315730001582 putative acyl-acceptor binding pocket; other site 315730001583 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730001585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730001586 DNA binding site [nucleotide binding] 315730001587 domain linker motif; other site 315730001588 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730001589 putative ligand binding site [chemical binding]; other site 315730001590 putative dimerization interface [polypeptide binding]; other site 315730001591 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730001592 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730001593 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730001594 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730001595 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730001596 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315730001597 active site 315730001598 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315730001599 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 315730001600 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 315730001601 lysozyme catalytic site [active] 315730001602 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315730001603 nucleotide binding site/active site [active] 315730001604 HIT family signature motif; other site 315730001605 catalytic residue [active] 315730001606 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730001607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001609 ABC transporter; Region: ABC_tran_2; pfam12848 315730001610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001611 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730001612 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315730001613 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315730001614 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730001615 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730001616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001617 dimer interface [polypeptide binding]; other site 315730001618 conserved gate region; other site 315730001619 putative PBP binding loops; other site 315730001620 ABC-ATPase subunit interface; other site 315730001621 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730001622 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730001623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001624 dimer interface [polypeptide binding]; other site 315730001625 conserved gate region; other site 315730001626 putative PBP binding loops; other site 315730001627 ABC-ATPase subunit interface; other site 315730001628 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730001629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730001630 Walker A/P-loop; other site 315730001631 ATP binding site [chemical binding]; other site 315730001632 Q-loop/lid; other site 315730001633 ABC transporter signature motif; other site 315730001634 Walker B; other site 315730001635 D-loop; other site 315730001636 H-loop/switch region; other site 315730001637 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315730001638 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 315730001639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730001640 Walker A/P-loop; other site 315730001641 ATP binding site [chemical binding]; other site 315730001642 Q-loop/lid; other site 315730001643 ABC transporter signature motif; other site 315730001644 Walker B; other site 315730001645 D-loop; other site 315730001646 H-loop/switch region; other site 315730001647 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315730001648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001649 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730001650 active site 315730001651 motif I; other site 315730001652 motif II; other site 315730001653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001654 motif II; other site 315730001655 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730001656 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001657 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001658 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001659 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001660 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001661 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 315730001662 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 315730001663 dimer interface [polypeptide binding]; other site 315730001664 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 315730001665 active site 315730001666 Fe binding site [ion binding]; other site 315730001667 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 315730001668 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 315730001669 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 315730001670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730001672 putative substrate translocation pore; other site 315730001673 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 315730001674 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315730001675 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 315730001676 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 315730001677 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730001678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730001679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730001680 helicase 45; Provisional; Region: PTZ00424 315730001681 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730001682 ATP binding site [chemical binding]; other site 315730001683 Mg++ binding site [ion binding]; other site 315730001684 motif III; other site 315730001685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730001686 nucleotide binding region [chemical binding]; other site 315730001687 ATP-binding site [chemical binding]; other site 315730001688 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 315730001689 Rhomboid family; Region: Rhomboid; pfam01694 315730001690 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 315730001691 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 315730001692 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730001693 alanine racemase; Reviewed; Region: alr; PRK00053 315730001694 active site 315730001695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730001696 dimer interface [polypeptide binding]; other site 315730001697 substrate binding site [chemical binding]; other site 315730001698 catalytic residues [active] 315730001699 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 315730001700 PemK-like protein; Region: PemK; pfam02452 315730001701 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 315730001702 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 315730001703 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 315730001704 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 315730001705 RNA binding site [nucleotide binding]; other site 315730001706 SprT homologues; Region: SprT; cl01182 315730001707 hypothetical protein; Provisional; Region: PRK04351 315730001708 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 315730001709 Glycoprotease family; Region: Peptidase_M22; pfam00814 315730001710 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 315730001711 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730001712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730001713 Coenzyme A binding pocket [chemical binding]; other site 315730001714 UGMP family protein; Validated; Region: PRK09604 315730001715 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 315730001716 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730001717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001719 ABC transporter; Region: ABC_tran_2; pfam12848 315730001720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730001721 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 315730001722 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 315730001723 CoA binding domain; Region: CoA_binding; pfam02629 315730001724 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 315730001725 CAAX protease self-immunity; Region: Abi; pfam02517 315730001726 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 315730001727 oligomerisation interface [polypeptide binding]; other site 315730001728 mobile loop; other site 315730001729 roof hairpin; other site 315730001730 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 315730001731 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 315730001732 ring oligomerisation interface [polypeptide binding]; other site 315730001733 ATP/Mg binding site [chemical binding]; other site 315730001734 stacking interactions; other site 315730001735 hinge regions; other site 315730001736 GMP synthase; Reviewed; Region: guaA; PRK00074 315730001737 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 315730001738 AMP/PPi binding site [chemical binding]; other site 315730001739 candidate oxyanion hole; other site 315730001740 catalytic triad [active] 315730001741 potential glutamine specificity residues [chemical binding]; other site 315730001742 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 315730001743 ATP Binding subdomain [chemical binding]; other site 315730001744 Ligand Binding sites [chemical binding]; other site 315730001745 Dimerization subdomain; other site 315730001746 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730001747 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730001748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730001749 active site 315730001750 phosphorylation site [posttranslational modification] 315730001751 intermolecular recognition site; other site 315730001752 dimerization interface [polypeptide binding]; other site 315730001753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730001754 DNA binding site [nucleotide binding] 315730001755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730001756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730001757 dimerization interface [polypeptide binding]; other site 315730001758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001759 dimer interface [polypeptide binding]; other site 315730001760 phosphorylation site [posttranslational modification] 315730001761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001762 ATP binding site [chemical binding]; other site 315730001763 Mg2+ binding site [ion binding]; other site 315730001764 G-X-G motif; other site 315730001765 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315730001766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730001767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730001768 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315730001769 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315730001770 catalytic residues [active] 315730001771 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 315730001772 putative ligand binding site [chemical binding]; other site 315730001773 putative catalytic site [active] 315730001774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001775 S-adenosylmethionine binding site [chemical binding]; other site 315730001776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001777 S-adenosylmethionine binding site [chemical binding]; other site 315730001778 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730001779 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 315730001780 putative NAD(P) binding site [chemical binding]; other site 315730001781 active site 315730001782 putative substrate binding site [chemical binding]; other site 315730001783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730001784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001785 S-adenosylmethionine binding site [chemical binding]; other site 315730001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730001787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730001788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730001789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730001790 active site 315730001791 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 315730001792 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 315730001793 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730001794 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 315730001795 Walker A/P-loop; other site 315730001796 ATP binding site [chemical binding]; other site 315730001797 Q-loop/lid; other site 315730001798 ABC transporter signature motif; other site 315730001799 Walker B; other site 315730001800 D-loop; other site 315730001801 H-loop/switch region; other site 315730001802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730001803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001804 dimer interface [polypeptide binding]; other site 315730001805 phosphorylation site [posttranslational modification] 315730001806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001807 ATP binding site [chemical binding]; other site 315730001808 Mg2+ binding site [ion binding]; other site 315730001809 G-X-G motif; other site 315730001810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730001812 active site 315730001813 phosphorylation site [posttranslational modification] 315730001814 intermolecular recognition site; other site 315730001815 dimerization interface [polypeptide binding]; other site 315730001816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730001817 DNA binding site [nucleotide binding] 315730001818 EamA-like transporter family; Region: EamA; pfam00892 315730001819 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730001820 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 315730001821 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 315730001822 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 315730001823 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 315730001824 NAD binding site [chemical binding]; other site 315730001825 ATP-grasp domain; Region: ATP-grasp; pfam02222 315730001826 adenylosuccinate lyase; Provisional; Region: PRK07492 315730001827 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 315730001828 tetramer interface [polypeptide binding]; other site 315730001829 active site 315730001830 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 315730001831 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 315730001832 ATP binding site [chemical binding]; other site 315730001833 active site 315730001834 substrate binding site [chemical binding]; other site 315730001835 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 315730001836 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 315730001837 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 315730001838 putative active site [active] 315730001839 catalytic triad [active] 315730001840 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 315730001841 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 315730001842 dimerization interface [polypeptide binding]; other site 315730001843 ATP binding site [chemical binding]; other site 315730001844 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 315730001845 dimerization interface [polypeptide binding]; other site 315730001846 ATP binding site [chemical binding]; other site 315730001847 amidophosphoribosyltransferase; Provisional; Region: PRK06781 315730001848 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 315730001849 active site 315730001850 tetramer interface [polypeptide binding]; other site 315730001851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001852 active site 315730001853 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 315730001854 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 315730001855 dimerization interface [polypeptide binding]; other site 315730001856 putative ATP binding site [chemical binding]; other site 315730001857 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 315730001858 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 315730001859 active site 315730001860 substrate binding site [chemical binding]; other site 315730001861 cosubstrate binding site; other site 315730001862 catalytic site [active] 315730001863 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 315730001864 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 315730001865 purine monophosphate binding site [chemical binding]; other site 315730001866 dimer interface [polypeptide binding]; other site 315730001867 putative catalytic residues [active] 315730001868 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 315730001869 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 315730001870 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 315730001871 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 315730001872 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 315730001873 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 315730001874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 315730001875 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 315730001876 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 315730001877 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 315730001878 PcrB family; Region: PcrB; pfam01884 315730001879 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 315730001880 substrate binding site [chemical binding]; other site 315730001881 putative active site [active] 315730001882 dimer interface [polypeptide binding]; other site 315730001883 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 315730001884 Part of AAA domain; Region: AAA_19; pfam13245 315730001885 Family description; Region: UvrD_C_2; pfam13538 315730001886 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 315730001887 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 315730001888 nucleotide binding pocket [chemical binding]; other site 315730001889 K-X-D-G motif; other site 315730001890 catalytic site [active] 315730001891 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 315730001892 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 315730001893 Dimer interface [polypeptide binding]; other site 315730001894 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 315730001895 putative dimer interface [polypeptide binding]; other site 315730001896 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 315730001897 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 315730001898 putative dimer interface [polypeptide binding]; other site 315730001899 hypothetical protein; Provisional; Region: PRK10621 315730001900 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730001901 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 315730001902 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 315730001903 Glutamate binding site [chemical binding]; other site 315730001904 homodimer interface [polypeptide binding]; other site 315730001905 NAD binding site [chemical binding]; other site 315730001906 catalytic residues [active] 315730001907 Isochorismatase family; Region: Isochorismatase; pfam00857 315730001908 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730001909 catalytic triad [active] 315730001910 conserved cis-peptide bond; other site 315730001911 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315730001912 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 315730001913 Walker A/P-loop; other site 315730001914 ATP binding site [chemical binding]; other site 315730001915 Q-loop/lid; other site 315730001916 ABC transporter signature motif; other site 315730001917 Walker B; other site 315730001918 D-loop; other site 315730001919 H-loop/switch region; other site 315730001920 NIL domain; Region: NIL; pfam09383 315730001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001922 dimer interface [polypeptide binding]; other site 315730001923 conserved gate region; other site 315730001924 ABC-ATPase subunit interface; other site 315730001925 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 315730001926 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 315730001927 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 315730001928 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 315730001929 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 315730001930 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 315730001931 P loop; other site 315730001932 Nucleotide binding site [chemical binding]; other site 315730001933 DTAP/Switch II; other site 315730001934 Switch I; other site 315730001935 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315730001936 putative dimer interface [polypeptide binding]; other site 315730001937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730001938 MarR family; Region: MarR; pfam01047 315730001939 MarR family; Region: MarR_2; cl17246 315730001940 yiaA/B two helix domain; Region: YiaAB; pfam05360 315730001941 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 315730001942 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 315730001943 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 315730001944 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 315730001945 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 315730001946 GatB domain; Region: GatB_Yqey; pfam02637 315730001947 putative lipid kinase; Reviewed; Region: PRK13337 315730001948 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 315730001949 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730001950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001951 motif II; other site 315730001952 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 315730001953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730001954 inhibitor-cofactor binding pocket; inhibition site 315730001955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001956 catalytic residue [active] 315730001957 PAS domain; Region: PAS_9; pfam13426 315730001958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730001959 putative active site [active] 315730001960 heme pocket [chemical binding]; other site 315730001961 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 315730001962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001963 Walker A motif; other site 315730001964 ATP binding site [chemical binding]; other site 315730001965 Walker B motif; other site 315730001966 arginine finger; other site 315730001967 succinic semialdehyde dehydrogenase; Region: PLN02278 315730001968 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 315730001969 tetramerization interface [polypeptide binding]; other site 315730001970 NAD(P) binding site [chemical binding]; other site 315730001971 catalytic residues [active] 315730001972 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315730001973 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315730001974 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 315730001975 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730001976 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 315730001977 putative active site [active] 315730001978 putative metal binding site [ion binding]; other site 315730001979 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730001980 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730001981 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730001982 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 315730001983 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315730001984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001985 S-adenosylmethionine binding site [chemical binding]; other site 315730001986 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 315730001987 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315730001988 FMN binding site [chemical binding]; other site 315730001989 active site 315730001990 catalytic residues [active] 315730001991 substrate binding site [chemical binding]; other site 315730001992 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 315730001993 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 315730001994 GAF domain; Region: GAF_3; pfam13492 315730001995 PAS domain S-box; Region: sensory_box; TIGR00229 315730001996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001997 dimer interface [polypeptide binding]; other site 315730001998 phosphorylation site [posttranslational modification] 315730001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002000 ATP binding site [chemical binding]; other site 315730002001 Mg2+ binding site [ion binding]; other site 315730002002 G-X-G motif; other site 315730002003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 315730002004 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 315730002005 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 315730002006 Protein of unknown function DUF45; Region: DUF45; pfam01863 315730002007 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315730002008 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315730002009 active site 315730002010 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730002011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730002012 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 315730002013 metal binding site [ion binding]; metal-binding site 315730002014 putative dimer interface [polypeptide binding]; other site 315730002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730002016 S-adenosylmethionine binding site [chemical binding]; other site 315730002017 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 315730002018 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 315730002019 catalytic residue [active] 315730002020 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 315730002021 catalytic residues [active] 315730002022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730002023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730002024 peroxiredoxin; Region: AhpC; TIGR03137 315730002025 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 315730002026 dimer interface [polypeptide binding]; other site 315730002027 decamer (pentamer of dimers) interface [polypeptide binding]; other site 315730002028 catalytic triad [active] 315730002029 peroxidatic and resolving cysteines [active] 315730002030 5-methylribose kinase; Reviewed; Region: PRK12396 315730002031 Phosphotransferase enzyme family; Region: APH; pfam01636 315730002032 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315730002033 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 315730002034 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 315730002035 intersubunit interface [polypeptide binding]; other site 315730002036 active site 315730002037 Zn2+ binding site [ion binding]; other site 315730002038 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730002039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002040 dimer interface [polypeptide binding]; other site 315730002041 putative PBP binding regions; other site 315730002042 ABC-ATPase subunit interface; other site 315730002043 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730002044 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002045 ABC-ATPase subunit interface; other site 315730002046 dimer interface [polypeptide binding]; other site 315730002047 putative PBP binding regions; other site 315730002048 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730002049 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730002050 putative ligand binding residues [chemical binding]; other site 315730002051 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730002052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730002053 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 315730002054 DNA binding domain, excisionase family; Region: excise; TIGR01764 315730002055 Sm and related proteins; Region: Sm_like; cl00259 315730002056 Sm1 motif; other site 315730002057 RNA binding site [nucleotide binding]; other site 315730002058 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 315730002059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002060 dimer interface [polypeptide binding]; other site 315730002061 phosphorylation site [posttranslational modification] 315730002062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002063 ATP binding site [chemical binding]; other site 315730002064 Mg2+ binding site [ion binding]; other site 315730002065 G-X-G motif; other site 315730002066 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 315730002067 hypothetical protein; Provisional; Region: PRK06851 315730002068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730002069 Walker A motif; other site 315730002070 ATP binding site [chemical binding]; other site 315730002071 NTPase; Region: NTPase_1; cl17478 315730002072 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 315730002073 benzoate transport; Region: 2A0115; TIGR00895 315730002074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002075 putative substrate translocation pore; other site 315730002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002077 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 315730002078 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730002079 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315730002080 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 315730002081 [2Fe-2S] cluster binding site [ion binding]; other site 315730002082 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315730002083 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 315730002084 putative di-iron ligands [ion binding]; other site 315730002085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002086 dimer interface [polypeptide binding]; other site 315730002087 conserved gate region; other site 315730002088 putative PBP binding loops; other site 315730002089 ABC-ATPase subunit interface; other site 315730002090 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730002091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730002092 substrate binding pocket [chemical binding]; other site 315730002093 membrane-bound complex binding site; other site 315730002094 hinge residues; other site 315730002095 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730002096 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315730002097 Walker A/P-loop; other site 315730002098 ATP binding site [chemical binding]; other site 315730002099 Q-loop/lid; other site 315730002100 ABC transporter signature motif; other site 315730002101 Walker B; other site 315730002102 D-loop; other site 315730002103 H-loop/switch region; other site 315730002104 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002106 dimerization interface [polypeptide binding]; other site 315730002107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002108 dimer interface [polypeptide binding]; other site 315730002109 putative CheW interface [polypeptide binding]; other site 315730002110 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730002111 FAD binding domain; Region: FAD_binding_4; pfam01565 315730002112 Berberine and berberine like; Region: BBE; pfam08031 315730002113 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730002114 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730002115 Ca binding site [ion binding]; other site 315730002116 active site 315730002117 catalytic site [active] 315730002118 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730002119 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 315730002120 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730002121 active site turn [active] 315730002122 phosphorylation site [posttranslational modification] 315730002123 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 315730002124 putative catalytic site [active] 315730002125 putative metal binding site [ion binding]; other site 315730002126 putative phosphate binding site [ion binding]; other site 315730002127 Predicted membrane protein [Function unknown]; Region: COG1511 315730002128 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730002129 Predicted membrane protein [Function unknown]; Region: COG1511 315730002130 Peptidase family M13; Region: Peptidase_M13_N; pfam05649 315730002131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002132 DNA topoisomerase III; Provisional; Region: PRK07726 315730002133 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730002134 active site 315730002135 putative interdomain interaction site [polypeptide binding]; other site 315730002136 putative metal-binding site [ion binding]; other site 315730002137 putative nucleotide binding site [chemical binding]; other site 315730002138 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730002139 domain I; other site 315730002140 DNA binding groove [nucleotide binding] 315730002141 phosphate binding site [ion binding]; other site 315730002142 domain II; other site 315730002143 domain III; other site 315730002144 nucleotide binding site [chemical binding]; other site 315730002145 catalytic site [active] 315730002146 domain IV; other site 315730002147 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 315730002148 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 315730002149 substrate binding site [chemical binding]; other site 315730002150 multimerization interface [polypeptide binding]; other site 315730002151 ATP binding site [chemical binding]; other site 315730002152 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315730002153 thiamine phosphate binding site [chemical binding]; other site 315730002154 active site 315730002155 pyrophosphate binding site [ion binding]; other site 315730002156 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 315730002157 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 315730002158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002159 dimerization interface [polypeptide binding]; other site 315730002160 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002162 dimer interface [polypeptide binding]; other site 315730002163 putative CheW interface [polypeptide binding]; other site 315730002164 Domain of unknown function DUF77; Region: DUF77; pfam01910 315730002165 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 315730002166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002167 dimer interface [polypeptide binding]; other site 315730002168 conserved gate region; other site 315730002169 putative PBP binding loops; other site 315730002170 ABC-ATPase subunit interface; other site 315730002171 NMT1/THI5 like; Region: NMT1; pfam09084 315730002172 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 315730002173 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730002174 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 315730002175 Walker A/P-loop; other site 315730002176 ATP binding site [chemical binding]; other site 315730002177 Q-loop/lid; other site 315730002178 ABC transporter signature motif; other site 315730002179 Walker B; other site 315730002180 D-loop; other site 315730002181 H-loop/switch region; other site 315730002182 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730002183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730002184 Walker A/P-loop; other site 315730002185 ATP binding site [chemical binding]; other site 315730002186 Q-loop/lid; other site 315730002187 ABC transporter signature motif; other site 315730002188 Walker B; other site 315730002189 D-loop; other site 315730002190 H-loop/switch region; other site 315730002191 ABC transporter; Region: ABC_tran_2; pfam12848 315730002192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730002193 Glyco_18 domain; Region: Glyco_18; smart00636 315730002194 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 315730002195 active site 315730002196 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730002197 Interdomain contacts; other site 315730002198 Cytokine receptor motif; other site 315730002199 Cellulose binding domain; Region: CBM_2; pfam00553 315730002200 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 315730002201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730002202 catalytic residues [active] 315730002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730002205 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 315730002206 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730002207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002208 putative substrate translocation pore; other site 315730002209 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730002210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002211 non-specific DNA binding site [nucleotide binding]; other site 315730002212 salt bridge; other site 315730002213 sequence-specific DNA binding site [nucleotide binding]; other site 315730002214 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 315730002215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002216 putative substrate translocation pore; other site 315730002217 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 315730002218 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 315730002219 YesK-like protein; Region: YesK; pfam14150 315730002220 prolyl-tRNA synthetase; Provisional; Region: PRK08661 315730002221 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 315730002222 dimer interface [polypeptide binding]; other site 315730002223 motif 1; other site 315730002224 active site 315730002225 motif 2; other site 315730002226 motif 3; other site 315730002227 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 315730002228 anticodon binding site; other site 315730002229 zinc-binding site [ion binding]; other site 315730002230 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315730002231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315730002232 nucleotide binding site [chemical binding]; other site 315730002233 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002234 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002235 putative metal binding site [ion binding]; other site 315730002236 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002237 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002238 putative metal binding site [ion binding]; other site 315730002239 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002240 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002241 putative metal binding site [ion binding]; other site 315730002242 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 315730002243 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 315730002244 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315730002245 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 315730002246 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315730002247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002248 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730002249 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730002250 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730002251 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 315730002252 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 315730002253 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730002254 active site 315730002255 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 315730002256 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 315730002257 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 315730002258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002259 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730002260 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730002261 EamA-like transporter family; Region: EamA; pfam00892 315730002262 EamA-like transporter family; Region: EamA; pfam00892 315730002263 YhhN-like protein; Region: YhhN; pfam07947 315730002264 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730002265 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730002266 Catalytic site [active] 315730002267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730002268 binding surface 315730002269 TPR motif; other site 315730002270 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730002271 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730002272 Predicted membrane protein [Function unknown]; Region: COG2510 315730002273 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 315730002274 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 315730002275 calcium/proton exchanger (cax); Region: cax; TIGR00378 315730002276 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315730002277 YfkD-like protein; Region: YfkD; pfam14167 315730002278 Radical SAM superfamily; Region: Radical_SAM; pfam04055 315730002279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730002280 FeS/SAM binding site; other site 315730002281 YfkB-like domain; Region: YfkB; pfam08756 315730002282 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 315730002283 Fumarase C-terminus; Region: Fumerase_C; pfam05683 315730002284 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 315730002285 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 315730002286 NodB motif; other site 315730002287 active site 315730002288 catalytic site [active] 315730002289 Cd binding site [ion binding]; other site 315730002290 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730002291 endonuclease III; Region: ENDO3c; smart00478 315730002292 minor groove reading motif; other site 315730002293 helix-hairpin-helix signature motif; other site 315730002294 substrate binding pocket [chemical binding]; other site 315730002295 active site 315730002296 TRAM domain; Region: TRAM; pfam01938 315730002297 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315730002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730002299 S-adenosylmethionine binding site [chemical binding]; other site 315730002300 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 315730002301 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 315730002302 dimerization interface 3.5A [polypeptide binding]; other site 315730002303 active site 315730002304 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315730002305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730002306 Walker A motif; other site 315730002307 ATP binding site [chemical binding]; other site 315730002308 Walker B motif; other site 315730002309 arginine finger; other site 315730002310 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315730002311 hypothetical protein; Validated; Region: PRK06748 315730002312 S-methylmethionine transporter; Provisional; Region: PRK11387 315730002313 acetylornithine deacetylase; Validated; Region: PRK08596 315730002314 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730002315 metal binding site [ion binding]; metal-binding site 315730002316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730002317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002318 non-specific DNA binding site [nucleotide binding]; other site 315730002319 salt bridge; other site 315730002320 sequence-specific DNA binding site [nucleotide binding]; other site 315730002321 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 315730002322 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315730002323 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 315730002324 glutaminase A; Region: Gln_ase; TIGR03814 315730002325 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 315730002326 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 315730002327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730002328 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730002329 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730002330 active site turn [active] 315730002331 phosphorylation site [posttranslational modification] 315730002332 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730002333 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730002334 Sm and related proteins; Region: Sm_like; cl00259 315730002335 heptamer interface [polypeptide binding]; other site 315730002336 Sm1 motif; other site 315730002337 hexamer interface [polypeptide binding]; other site 315730002338 RNA binding site [nucleotide binding]; other site 315730002339 Sm2 motif; other site 315730002340 Sm and related proteins; Region: Sm_like; cl00259 315730002341 heptamer interface [polypeptide binding]; other site 315730002342 Sm1 motif; other site 315730002343 hexamer interface [polypeptide binding]; other site 315730002344 RNA binding site [nucleotide binding]; other site 315730002345 Sm2 motif; other site 315730002346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730002347 active site 315730002348 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730002349 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 315730002350 active site 315730002351 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 315730002352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002353 NAD(P) binding site [chemical binding]; other site 315730002354 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730002355 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315730002356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002357 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730002358 NAD(P) binding site [chemical binding]; other site 315730002359 active site 315730002360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730002361 active site 315730002362 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730002363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730002364 active site 315730002365 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 315730002366 Pyruvate formate lyase 1; Region: PFL1; cd01678 315730002367 coenzyme A binding site [chemical binding]; other site 315730002368 active site 315730002369 catalytic residues [active] 315730002370 glycine loop; other site 315730002371 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 315730002372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730002373 FeS/SAM binding site; other site 315730002374 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 315730002375 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 315730002376 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315730002377 YfhE-like protein; Region: YfhE; pfam14152 315730002378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730002379 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 315730002380 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 315730002381 active site 315730002382 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 315730002383 TIGR01777 family protein; Region: yfcH 315730002384 putative NAD(P) binding site [chemical binding]; other site 315730002385 putative active site [active] 315730002386 recombination regulator RecX; Provisional; Region: recX; PRK14135 315730002387 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 315730002388 YpzG-like protein; Region: YpzG; pfam14139 315730002389 Small acid-soluble spore protein K family; Region: SspK; pfam08176 315730002390 WVELL protein; Region: WVELL; pfam14043 315730002391 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 315730002392 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 315730002393 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730002394 minor groove reading motif; other site 315730002395 helix-hairpin-helix signature motif; other site 315730002396 substrate binding pocket [chemical binding]; other site 315730002397 active site 315730002398 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 315730002399 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 315730002400 DNA binding and oxoG recognition site [nucleotide binding] 315730002401 YgaB-like protein; Region: YgaB; pfam14182 315730002402 hypothetical protein; Provisional; Region: PRK13662 315730002403 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730002404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730002405 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 315730002406 Walker A/P-loop; other site 315730002407 ATP binding site [chemical binding]; other site 315730002408 Q-loop/lid; other site 315730002409 ABC transporter signature motif; other site 315730002410 Walker B; other site 315730002411 D-loop; other site 315730002412 H-loop/switch region; other site 315730002413 Predicted membrane protein [Function unknown]; Region: COG4129 315730002414 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 315730002415 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 315730002416 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 315730002417 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 315730002418 active site 315730002419 dimer interface [polypeptide binding]; other site 315730002420 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 315730002421 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315730002422 active site 315730002423 FMN binding site [chemical binding]; other site 315730002424 substrate binding site [chemical binding]; other site 315730002425 3Fe-4S cluster binding site [ion binding]; other site 315730002426 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 315730002427 domain_subunit interface; other site 315730002428 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 315730002429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730002430 inhibitor-cofactor binding pocket; inhibition site 315730002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002432 catalytic residue [active] 315730002433 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 315730002434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730002435 Walker A/P-loop; other site 315730002436 ATP binding site [chemical binding]; other site 315730002437 Q-loop/lid; other site 315730002438 ABC transporter signature motif; other site 315730002439 Walker B; other site 315730002440 D-loop; other site 315730002441 H-loop/switch region; other site 315730002442 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 315730002443 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 315730002444 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 315730002445 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 315730002446 Ion channel; Region: Ion_trans_2; pfam07885 315730002447 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 315730002448 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 315730002449 catalytic triad [active] 315730002450 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730002451 metal binding site 2 [ion binding]; metal-binding site 315730002452 putative DNA binding helix; other site 315730002453 metal binding site 1 [ion binding]; metal-binding site 315730002454 dimer interface [polypeptide binding]; other site 315730002455 structural Zn2+ binding site [ion binding]; other site 315730002456 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 315730002457 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 315730002458 hypothetical protein; Provisional; Region: PRK12378 315730002459 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730002460 nudix motif; other site 315730002461 Transglycosylase; Region: Transgly; pfam00912 315730002462 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 315730002463 Thioredoxin; Region: Thioredoxin_4; pfam13462 315730002464 epoxyqueuosine reductase; Region: TIGR00276 315730002465 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 315730002466 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315730002467 Putative amidase domain; Region: Amidase_6; pfam12671 315730002468 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 315730002469 PAS fold; Region: PAS_4; pfam08448 315730002470 PAS fold; Region: PAS; pfam00989 315730002471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730002472 putative active site [active] 315730002473 heme pocket [chemical binding]; other site 315730002474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730002475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730002476 metal binding site [ion binding]; metal-binding site 315730002477 active site 315730002478 I-site; other site 315730002479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730002480 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 315730002481 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 315730002482 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 315730002483 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730002484 heme-binding site [chemical binding]; other site 315730002485 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 315730002486 LRR adjacent; Region: LRR_adjacent; pfam08191 315730002487 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730002488 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730002489 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730002490 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 315730002491 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 315730002493 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 315730002494 Tar ligand binding domain homologue; Region: TarH; pfam02203 315730002495 Cache domain; Region: Cache_1; pfam02743 315730002496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002497 dimerization interface [polypeptide binding]; other site 315730002498 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002500 dimer interface [polypeptide binding]; other site 315730002501 putative CheW interface [polypeptide binding]; other site 315730002502 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315730002503 PAS domain; Region: PAS; smart00091 315730002504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002505 ATP binding site [chemical binding]; other site 315730002506 Mg2+ binding site [ion binding]; other site 315730002507 G-X-G motif; other site 315730002508 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315730002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002510 active site 315730002511 phosphorylation site [posttranslational modification] 315730002512 intermolecular recognition site; other site 315730002513 dimerization interface [polypeptide binding]; other site 315730002514 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 315730002515 Citrate transporter; Region: CitMHS; pfam03600 315730002516 hypothetical protein; Provisional; Region: PRK12784 315730002517 NosL; Region: NosL; cl01769 315730002518 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002519 Ankyrin repeat; Region: Ank; pfam00023 315730002520 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002521 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730002522 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002523 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 315730002524 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730002525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730002526 Walker A/P-loop; other site 315730002527 ATP binding site [chemical binding]; other site 315730002528 Q-loop/lid; other site 315730002529 ABC transporter signature motif; other site 315730002530 Walker B; other site 315730002531 D-loop; other site 315730002532 H-loop/switch region; other site 315730002533 TOBE domain; Region: TOBE_2; pfam08402 315730002534 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315730002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002536 dimer interface [polypeptide binding]; other site 315730002537 conserved gate region; other site 315730002538 putative PBP binding loops; other site 315730002539 ABC-ATPase subunit interface; other site 315730002540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315730002541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002543 dimer interface [polypeptide binding]; other site 315730002544 conserved gate region; other site 315730002545 putative PBP binding loops; other site 315730002546 ABC-ATPase subunit interface; other site 315730002547 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315730002548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315730002549 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730002550 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315730002551 active site 315730002552 metal binding site [ion binding]; metal-binding site 315730002553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002555 active site 315730002556 phosphorylation site [posttranslational modification] 315730002557 intermolecular recognition site; other site 315730002558 dimerization interface [polypeptide binding]; other site 315730002559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002560 DNA binding site [nucleotide binding] 315730002561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730002562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002563 dimer interface [polypeptide binding]; other site 315730002564 phosphorylation site [posttranslational modification] 315730002565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002566 ATP binding site [chemical binding]; other site 315730002567 Mg2+ binding site [ion binding]; other site 315730002568 G-X-G motif; other site 315730002569 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 315730002570 putative active site [active] 315730002571 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315730002572 Cache domain; Region: Cache_1; pfam02743 315730002573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002574 dimerization interface [polypeptide binding]; other site 315730002575 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002577 dimer interface [polypeptide binding]; other site 315730002578 putative CheW interface [polypeptide binding]; other site 315730002579 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315730002580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002581 ATP binding site [chemical binding]; other site 315730002582 Mg2+ binding site [ion binding]; other site 315730002583 G-X-G motif; other site 315730002584 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315730002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002586 active site 315730002587 phosphorylation site [posttranslational modification] 315730002588 intermolecular recognition site; other site 315730002589 dimerization interface [polypeptide binding]; other site 315730002590 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 315730002591 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315730002592 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730002593 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315730002594 putative NAD(P) binding site [chemical binding]; other site 315730002595 EamA-like transporter family; Region: EamA; pfam00892 315730002596 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730002597 EamA-like transporter family; Region: EamA; pfam00892 315730002598 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730002599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730002600 DNA-binding site [nucleotide binding]; DNA binding site 315730002601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002603 homodimer interface [polypeptide binding]; other site 315730002604 catalytic residue [active] 315730002605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730002606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730002607 Coenzyme A binding pocket [chemical binding]; other site 315730002608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730002609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002610 dimerization interface [polypeptide binding]; other site 315730002611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002612 dimer interface [polypeptide binding]; other site 315730002613 phosphorylation site [posttranslational modification] 315730002614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002615 ATP binding site [chemical binding]; other site 315730002616 Mg2+ binding site [ion binding]; other site 315730002617 G-X-G motif; other site 315730002618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002620 active site 315730002621 phosphorylation site [posttranslational modification] 315730002622 intermolecular recognition site; other site 315730002623 dimerization interface [polypeptide binding]; other site 315730002624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002625 DNA binding site [nucleotide binding] 315730002626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730002627 Arrestin_N terminal like; Region: LDB19; pfam13002 315730002628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730002629 Coenzyme A binding pocket [chemical binding]; other site 315730002630 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 315730002631 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 315730002632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 315730002633 catalytic loop [active] 315730002634 iron binding site [ion binding]; other site 315730002635 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 315730002636 4Fe-4S binding domain; Region: Fer4; pfam00037 315730002637 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 315730002638 [4Fe-4S] binding site [ion binding]; other site 315730002639 molybdopterin cofactor binding site; other site 315730002640 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 315730002641 molybdopterin cofactor binding site; other site 315730002642 Uncharacterized conserved protein [Function unknown]; Region: COG2427 315730002643 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 315730002644 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730002645 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 315730002646 putative active site [active] 315730002647 catalytic site [active] 315730002648 putative metal binding site [ion binding]; other site 315730002649 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730002650 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 315730002651 hexamer interface [polypeptide binding]; other site 315730002652 ligand binding site [chemical binding]; other site 315730002653 putative active site [active] 315730002654 NAD(P) binding site [chemical binding]; other site 315730002655 amino acid transporter; Region: 2A0306; TIGR00909 315730002656 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 315730002657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 315730002658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730002659 dimerization interface [polypeptide binding]; other site 315730002660 putative DNA binding site [nucleotide binding]; other site 315730002661 putative Zn2+ binding site [ion binding]; other site 315730002662 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730002663 metal-binding site [ion binding] 315730002664 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730002665 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730002666 metal-binding site [ion binding] 315730002667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002668 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730002669 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 315730002670 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 315730002671 active site 315730002672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002673 non-specific DNA binding site [nucleotide binding]; other site 315730002674 salt bridge; other site 315730002675 sequence-specific DNA binding site [nucleotide binding]; other site 315730002676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730002677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730002678 binding surface 315730002679 TPR motif; other site 315730002680 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730002681 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730002682 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315730002683 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730002684 active site 315730002685 Zn binding site [ion binding]; other site 315730002686 Uncharacterized conserved protein [Function unknown]; Region: COG0398 315730002687 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730002688 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 315730002689 VanW like protein; Region: VanW; pfam04294 315730002690 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730002691 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730002692 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730002693 Nucleoside recognition; Region: Gate; pfam07670 315730002694 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730002695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730002696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 315730002697 putative metal binding site [ion binding]; other site 315730002698 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730002699 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730002700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730002701 Transporter associated domain; Region: CorC_HlyC; smart01091 315730002702 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 315730002703 Aspartase; Region: Aspartase; cd01357 315730002704 active sites [active] 315730002705 tetramer interface [polypeptide binding]; other site 315730002706 L-lactate permease; Region: Lactate_perm; cl00701 315730002707 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 315730002708 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 315730002709 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730002710 catalytic residues [active] 315730002711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730002712 dimerization interface [polypeptide binding]; other site 315730002713 putative Zn2+ binding site [ion binding]; other site 315730002714 putative DNA binding site [nucleotide binding]; other site 315730002715 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 315730002716 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730002717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002718 putative substrate translocation pore; other site 315730002719 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730002720 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730002721 siderophore binding site; other site 315730002722 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730002723 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002724 ABC-ATPase subunit interface; other site 315730002725 dimer interface [polypeptide binding]; other site 315730002726 putative PBP binding regions; other site 315730002727 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730002728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002729 ABC-ATPase subunit interface; other site 315730002730 dimer interface [polypeptide binding]; other site 315730002731 putative PBP binding regions; other site 315730002732 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730002733 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730002734 Walker A/P-loop; other site 315730002735 ATP binding site [chemical binding]; other site 315730002736 Q-loop/lid; other site 315730002737 ABC transporter signature motif; other site 315730002738 Walker B; other site 315730002739 D-loop; other site 315730002740 H-loop/switch region; other site 315730002741 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730002742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730002743 S-adenosylmethionine binding site [chemical binding]; other site 315730002744 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 315730002745 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315730002746 substrate-cofactor binding pocket; other site 315730002747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002748 catalytic residue [active] 315730002749 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730002750 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 315730002751 NAD binding site [chemical binding]; other site 315730002752 homodimer interface [polypeptide binding]; other site 315730002753 active site 315730002754 putative substrate binding site [chemical binding]; other site 315730002755 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730002756 nudix motif; other site 315730002757 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 315730002758 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 315730002759 metal ion-dependent adhesion site (MIDAS); other site 315730002760 MoxR-like ATPases [General function prediction only]; Region: COG0714 315730002761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730002762 Walker A motif; other site 315730002763 ATP binding site [chemical binding]; other site 315730002764 Walker B motif; other site 315730002765 arginine finger; other site 315730002766 cardiolipin synthetase; Reviewed; Region: PRK12452 315730002767 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730002768 putative active site [active] 315730002769 catalytic site [active] 315730002770 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730002771 putative active site [active] 315730002772 catalytic site [active] 315730002773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730002774 PAS domain; Region: PAS_9; pfam13426 315730002775 putative active site [active] 315730002776 heme pocket [chemical binding]; other site 315730002777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730002778 metal binding site [ion binding]; metal-binding site 315730002779 active site 315730002780 I-site; other site 315730002781 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730002782 Amino acid permease; Region: AA_permease_2; pfam13520 315730002783 Spore germination protein; Region: Spore_permease; cl17796 315730002784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730002785 DNA-binding site [nucleotide binding]; DNA binding site 315730002786 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 315730002787 UTRA domain; Region: UTRA; pfam07702 315730002788 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 315730002789 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730002790 active site turn [active] 315730002791 phosphorylation site [posttranslational modification] 315730002792 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730002793 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730002794 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730002795 Ca binding site [ion binding]; other site 315730002796 active site 315730002797 catalytic site [active] 315730002798 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730002799 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730002800 Spore germination protein; Region: Spore_permease; cl17796 315730002801 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730002802 CAAX protease self-immunity; Region: Abi; pfam02517 315730002803 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 315730002804 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315730002805 active site 315730002806 ATP binding site [chemical binding]; other site 315730002807 substrate binding site [chemical binding]; other site 315730002808 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730002809 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 315730002810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730002811 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315730002812 Walker A/P-loop; other site 315730002813 ATP binding site [chemical binding]; other site 315730002814 Q-loop/lid; other site 315730002815 ABC transporter signature motif; other site 315730002816 Walker B; other site 315730002817 D-loop; other site 315730002818 H-loop/switch region; other site 315730002819 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730002820 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730002821 substrate binding pocket [chemical binding]; other site 315730002822 membrane-bound complex binding site; other site 315730002823 hinge residues; other site 315730002824 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730002825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002826 dimer interface [polypeptide binding]; other site 315730002827 conserved gate region; other site 315730002828 putative PBP binding loops; other site 315730002829 ABC-ATPase subunit interface; other site 315730002830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002831 dimer interface [polypeptide binding]; other site 315730002832 conserved gate region; other site 315730002833 putative PBP binding loops; other site 315730002834 ABC-ATPase subunit interface; other site 315730002835 S-methylmethionine transporter; Provisional; Region: PRK11387 315730002836 OsmC-like protein; Region: OsmC; pfam02566 315730002837 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 315730002838 nucleotide binding site/active site [active] 315730002839 RNA polymerase sigma factor; Provisional; Region: PRK12542 315730002840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730002841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730002842 DNA binding residues [nucleotide binding] 315730002843 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315730002844 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730002845 HTH domain; Region: HTH_11; pfam08279 315730002846 WYL domain; Region: WYL; pfam13280 315730002847 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 315730002848 RibD C-terminal domain; Region: RibD_C; cl17279 315730002849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002850 dimerization interface [polypeptide binding]; other site 315730002851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002852 dimer interface [polypeptide binding]; other site 315730002853 phosphorylation site [posttranslational modification] 315730002854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002855 ATP binding site [chemical binding]; other site 315730002856 Mg2+ binding site [ion binding]; other site 315730002857 G-X-G motif; other site 315730002858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002860 active site 315730002861 phosphorylation site [posttranslational modification] 315730002862 intermolecular recognition site; other site 315730002863 dimerization interface [polypeptide binding]; other site 315730002864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002865 DNA binding site [nucleotide binding] 315730002866 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315730002867 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315730002868 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 315730002869 Sulfate transporter family; Region: Sulfate_transp; pfam00916 315730002870 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315730002871 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315730002872 Ligand Binding Site [chemical binding]; other site 315730002873 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 315730002874 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 315730002875 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315730002876 peptide binding site [polypeptide binding]; other site 315730002877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730002878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002879 dimer interface [polypeptide binding]; other site 315730002880 conserved gate region; other site 315730002881 putative PBP binding loops; other site 315730002882 ABC-ATPase subunit interface; other site 315730002883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002885 dimer interface [polypeptide binding]; other site 315730002886 conserved gate region; other site 315730002887 putative PBP binding loops; other site 315730002888 ABC-ATPase subunit interface; other site 315730002889 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315730002890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730002891 Walker A/P-loop; other site 315730002892 ATP binding site [chemical binding]; other site 315730002893 Q-loop/lid; other site 315730002894 ABC transporter signature motif; other site 315730002895 Walker B; other site 315730002896 D-loop; other site 315730002897 H-loop/switch region; other site 315730002898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 315730002899 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730002900 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730002901 Walker A/P-loop; other site 315730002902 ATP binding site [chemical binding]; other site 315730002903 Q-loop/lid; other site 315730002904 ABC transporter signature motif; other site 315730002905 Walker B; other site 315730002906 D-loop; other site 315730002907 H-loop/switch region; other site 315730002908 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315730002909 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 315730002910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002911 putative substrate translocation pore; other site 315730002912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730002913 MarR family; Region: MarR; pfam01047 315730002914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730002916 putative substrate translocation pore; other site 315730002917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730002918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730002919 DNA binding site [nucleotide binding] 315730002920 domain linker motif; other site 315730002921 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 315730002922 dimerization interface [polypeptide binding]; other site 315730002923 ligand binding site [chemical binding]; other site 315730002924 sodium binding site [ion binding]; other site 315730002925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315730002926 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 315730002927 substrate binding site [chemical binding]; other site 315730002928 dimer interface [polypeptide binding]; other site 315730002929 ATP binding site [chemical binding]; other site 315730002930 D-ribose pyranase; Provisional; Region: PRK11797 315730002931 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730002932 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315730002933 Walker A/P-loop; other site 315730002934 ATP binding site [chemical binding]; other site 315730002935 Q-loop/lid; other site 315730002936 ABC transporter signature motif; other site 315730002937 Walker B; other site 315730002938 D-loop; other site 315730002939 H-loop/switch region; other site 315730002940 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315730002941 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730002942 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730002943 TM-ABC transporter signature motif; other site 315730002944 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 315730002945 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 315730002946 ligand binding site [chemical binding]; other site 315730002947 dimerization interface [polypeptide binding]; other site 315730002948 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315730002949 active site 315730002950 intersubunit interactions; other site 315730002951 catalytic residue [active] 315730002952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730002953 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 315730002954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730002956 putative substrate translocation pore; other site 315730002957 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 315730002958 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315730002959 putative NAD(P) binding site [chemical binding]; other site 315730002960 catalytic Zn binding site [ion binding]; other site 315730002961 Ion channel; Region: Ion_trans_2; pfam07885 315730002962 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 315730002963 Zn binding site [ion binding]; other site 315730002964 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 315730002965 putative catalytic site [active] 315730002966 metal binding site A [ion binding]; metal-binding site 315730002967 phosphate binding site [ion binding]; other site 315730002968 metal binding site C [ion binding]; metal-binding site 315730002969 metal binding site B [ion binding]; metal-binding site 315730002970 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 315730002971 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 315730002972 dimer interface [polypeptide binding]; other site 315730002973 active site 315730002974 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730002975 substrate binding site [chemical binding]; other site 315730002976 catalytic residue [active] 315730002977 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 315730002978 FAD binding domain; Region: FAD_binding_4; pfam01565 315730002979 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 315730002980 VanZ like family; Region: VanZ; pfam04892 315730002981 RDD family; Region: RDD; pfam06271 315730002982 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 315730002983 IncA protein; Region: IncA; pfam04156 315730002984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002986 dimer interface [polypeptide binding]; other site 315730002987 putative CheW interface [polypeptide binding]; other site 315730002988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730002989 3D domain; Region: 3D; cl01439 315730002990 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730002991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002992 non-specific DNA binding site [nucleotide binding]; other site 315730002993 salt bridge; other site 315730002994 sequence-specific DNA binding site [nucleotide binding]; other site 315730002995 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 315730002996 active site 315730002997 catalytic site [active] 315730002998 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730002999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003000 POT family; Region: PTR2; cl17359 315730003001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003002 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315730003003 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 315730003004 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 315730003005 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315730003006 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 315730003007 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730003008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730003009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730003010 non-specific DNA binding site [nucleotide binding]; other site 315730003011 salt bridge; other site 315730003012 sequence-specific DNA binding site [nucleotide binding]; other site 315730003013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730003014 Coenzyme A binding pocket [chemical binding]; other site 315730003015 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 315730003016 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315730003017 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730003018 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730003019 TrkA-N domain; Region: TrkA_N; pfam02254 315730003020 TrkA-C domain; Region: TrkA_C; pfam02080 315730003021 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315730003022 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315730003023 Subunit I/III interface [polypeptide binding]; other site 315730003024 Subunit III/IV interface [polypeptide binding]; other site 315730003025 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315730003026 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315730003027 D-pathway; other site 315730003028 Putative ubiquinol binding site [chemical binding]; other site 315730003029 Low-spin heme (heme b) binding site [chemical binding]; other site 315730003030 Putative water exit pathway; other site 315730003031 Binuclear center (heme o3/CuB) [ion binding]; other site 315730003032 K-pathway; other site 315730003033 Putative proton exit pathway; other site 315730003034 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 315730003035 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 315730003036 putative active site [active] 315730003037 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730003038 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730003039 metal binding site [ion binding]; metal-binding site 315730003040 dimer interface [polypeptide binding]; other site 315730003041 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 315730003042 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 315730003043 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730003044 Na binding site [ion binding]; other site 315730003045 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730003046 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 315730003047 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730003048 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730003049 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 315730003050 Nucleoside recognition; Region: Gate; pfam07670 315730003051 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 315730003052 Nucleoside recognition; Region: Gate; pfam07670 315730003053 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 315730003054 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 315730003055 G1 box; other site 315730003056 GTP/Mg2+ binding site [chemical binding]; other site 315730003057 Switch I region; other site 315730003058 G2 box; other site 315730003059 G3 box; other site 315730003060 Switch II region; other site 315730003061 G4 box; other site 315730003062 G5 box; other site 315730003063 FeoA domain; Region: FeoA; pfam04023 315730003064 PBP superfamily domain; Region: PBP_like_2; cl17296 315730003065 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730003066 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 315730003067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003068 dimer interface [polypeptide binding]; other site 315730003069 conserved gate region; other site 315730003070 putative PBP binding loops; other site 315730003071 ABC-ATPase subunit interface; other site 315730003072 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 315730003073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003074 dimer interface [polypeptide binding]; other site 315730003075 conserved gate region; other site 315730003076 putative PBP binding loops; other site 315730003077 ABC-ATPase subunit interface; other site 315730003078 FOG: CBS domain [General function prediction only]; Region: COG0517 315730003079 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 315730003080 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 315730003081 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 315730003082 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730003083 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730003084 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730003085 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730003086 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730003087 Putative transcription activator [Transcription]; Region: TenA; COG0819 315730003088 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730003089 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 315730003090 Walker A/P-loop; other site 315730003091 ATP binding site [chemical binding]; other site 315730003092 Q-loop/lid; other site 315730003093 ABC transporter signature motif; other site 315730003094 Walker B; other site 315730003095 D-loop; other site 315730003096 H-loop/switch region; other site 315730003097 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 315730003098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003099 dimer interface [polypeptide binding]; other site 315730003100 conserved gate region; other site 315730003101 putative PBP binding loops; other site 315730003102 ABC-ATPase subunit interface; other site 315730003103 NMT1/THI5 like; Region: NMT1; pfam09084 315730003104 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 315730003105 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315730003106 thiamine phosphate binding site [chemical binding]; other site 315730003107 active site 315730003108 pyrophosphate binding site [ion binding]; other site 315730003109 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 315730003110 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 315730003111 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 315730003112 thiS-thiF/thiG interaction site; other site 315730003113 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 315730003114 ThiS interaction site; other site 315730003115 putative active site [active] 315730003116 tetramer interface [polypeptide binding]; other site 315730003117 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315730003118 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730003119 ATP binding site [chemical binding]; other site 315730003120 substrate interface [chemical binding]; other site 315730003121 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315730003122 dimer interface [polypeptide binding]; other site 315730003123 substrate binding site [chemical binding]; other site 315730003124 ATP binding site [chemical binding]; other site 315730003125 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 315730003126 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 315730003127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730003128 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730003129 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 315730003130 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 315730003131 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 315730003132 Ligand Binding Site [chemical binding]; other site 315730003133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730003135 putative substrate translocation pore; other site 315730003136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730003137 MarR family; Region: MarR; pfam01047 315730003138 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 315730003139 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 315730003140 active site 315730003141 nucleophile elbow; other site 315730003142 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 315730003143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730003144 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730003145 TM-ABC transporter signature motif; other site 315730003146 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315730003147 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730003148 Walker A/P-loop; other site 315730003149 ATP binding site [chemical binding]; other site 315730003150 Q-loop/lid; other site 315730003151 ABC transporter signature motif; other site 315730003152 Walker B; other site 315730003153 D-loop; other site 315730003154 H-loop/switch region; other site 315730003155 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315730003156 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 315730003157 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315730003158 putative ligand binding site [chemical binding]; other site 315730003159 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730003160 short chain dehydrogenase; Provisional; Region: PRK06701 315730003161 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315730003162 NAD binding site [chemical binding]; other site 315730003163 metal binding site [ion binding]; metal-binding site 315730003164 active site 315730003165 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315730003166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 315730003167 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315730003168 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730003169 catalytic residues [active] 315730003170 putative disulfide oxidoreductase; Provisional; Region: PRK03113 315730003171 YhdB-like protein; Region: YhdB; pfam14148 315730003172 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 315730003173 Spore germination protein; Region: Spore_permease; cl17796 315730003174 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730003175 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730003176 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730003177 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 315730003178 putative FMN binding site [chemical binding]; other site 315730003179 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 315730003180 SpoVR like protein; Region: SpoVR; pfam04293 315730003181 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 315730003182 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 315730003183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730003184 MarR family; Region: MarR_2; pfam12802 315730003185 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 315730003186 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 315730003187 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 315730003188 putative homodimer interface [polypeptide binding]; other site 315730003189 putative homotetramer interface [polypeptide binding]; other site 315730003190 putative metal binding site [ion binding]; other site 315730003191 putative homodimer-homodimer interface [polypeptide binding]; other site 315730003192 putative allosteric switch controlling residues; other site 315730003193 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315730003194 CPxP motif; other site 315730003195 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003196 active site residue [active] 315730003197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 315730003198 active site residue [active] 315730003199 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730003200 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315730003201 CPxP motif; other site 315730003202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003203 active site residue [active] 315730003204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003205 active site residue [active] 315730003206 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 315730003207 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730003208 Transcriptional regulator [Transcription]; Region: LytR; COG1316 315730003209 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 315730003210 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 315730003211 NADP binding site [chemical binding]; other site 315730003212 dimer interface [polypeptide binding]; other site 315730003213 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 315730003214 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315730003215 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315730003216 PhoU domain; Region: PhoU; pfam01895 315730003217 PhoU domain; Region: PhoU; pfam01895 315730003218 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730003219 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 315730003220 putative NAD(P) binding site [chemical binding]; other site 315730003221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730003223 putative substrate translocation pore; other site 315730003224 Uncharacterized conserved protein [Function unknown]; Region: COG3589 315730003225 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 315730003226 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315730003227 HTH domain; Region: HTH_11; pfam08279 315730003228 Mga helix-turn-helix domain; Region: Mga; pfam05043 315730003229 PRD domain; Region: PRD; pfam00874 315730003230 PRD domain; Region: PRD; pfam00874 315730003231 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315730003232 active site 315730003233 P-loop; other site 315730003234 phosphorylation site [posttranslational modification] 315730003235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315730003236 active site 315730003237 phosphorylation site [posttranslational modification] 315730003238 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730003239 active site 315730003240 methionine cluster; other site 315730003241 phosphorylation site [posttranslational modification] 315730003242 metal binding site [ion binding]; metal-binding site 315730003243 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730003244 active site 315730003245 P-loop; other site 315730003246 phosphorylation site [posttranslational modification] 315730003247 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 315730003248 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730003249 Uncharacterized conserved protein [Function unknown]; Region: COG3589 315730003250 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 315730003251 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730003252 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730003253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315730003254 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730003255 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730003256 FtsX-like permease family; Region: FtsX; pfam02687 315730003257 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730003258 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730003259 Walker A/P-loop; other site 315730003260 ATP binding site [chemical binding]; other site 315730003261 Q-loop/lid; other site 315730003262 ABC transporter signature motif; other site 315730003263 Walker B; other site 315730003264 D-loop; other site 315730003265 H-loop/switch region; other site 315730003266 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 315730003267 HlyD family secretion protein; Region: HlyD_3; pfam13437 315730003268 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 315730003269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730003270 dimer interface [polypeptide binding]; other site 315730003271 conserved gate region; other site 315730003272 putative PBP binding loops; other site 315730003273 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 315730003274 ABC-ATPase subunit interface; other site 315730003275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730003276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003277 dimer interface [polypeptide binding]; other site 315730003278 conserved gate region; other site 315730003279 ABC-ATPase subunit interface; other site 315730003280 FtsX-like permease family; Region: FtsX; pfam02687 315730003281 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315730003282 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315730003283 dimanganese center [ion binding]; other site 315730003284 CotJB protein; Region: CotJB; pfam12652 315730003285 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 315730003286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730003288 active site 315730003289 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003290 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003291 Uncharacterized conserved protein [Function unknown]; Region: COG3339 315730003292 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730003293 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730003294 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003295 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003296 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003297 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730003298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315730003299 active site 315730003300 metal binding site [ion binding]; metal-binding site 315730003301 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730003302 Interdomain contacts; other site 315730003303 Cytokine receptor motif; other site 315730003304 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 315730003305 amino acid transporter; Region: 2A0306; TIGR00909 315730003306 Spore germination protein; Region: Spore_permease; cl17796 315730003307 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 315730003308 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315730003309 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730003310 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315730003311 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315730003312 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315730003313 putative active site [active] 315730003314 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 315730003315 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 315730003316 putative active site [active] 315730003317 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 315730003318 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730003319 active site turn [active] 315730003320 phosphorylation site [posttranslational modification] 315730003321 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730003322 Uncharacterized conserved protein [Function unknown]; Region: COG3589 315730003323 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 315730003324 DoxX; Region: DoxX; pfam07681 315730003325 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730003326 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 315730003327 hypothetical protein; Provisional; Region: PRK06770 315730003328 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730003329 EamA-like transporter family; Region: EamA; pfam00892 315730003330 EamA-like transporter family; Region: EamA; pfam00892 315730003331 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730003332 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 315730003333 AsnC family; Region: AsnC_trans_reg; pfam01037 315730003334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730003335 Coenzyme A binding pocket [chemical binding]; other site 315730003336 short chain dehydrogenase; Provisional; Region: PRK06138 315730003337 classical (c) SDRs; Region: SDR_c; cd05233 315730003338 NAD(P) binding site [chemical binding]; other site 315730003339 active site 315730003340 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 315730003341 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730003342 DNA binding residues [nucleotide binding] 315730003343 putative dimer interface [polypeptide binding]; other site 315730003344 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315730003345 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315730003346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730003350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003351 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730003352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730003353 dimerization interface [polypeptide binding]; other site 315730003354 putative DNA binding site [nucleotide binding]; other site 315730003355 putative Zn2+ binding site [ion binding]; other site 315730003356 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 315730003357 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730003358 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 315730003359 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315730003360 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315730003361 proposed catalytic triad [active] 315730003362 conserved cys residue [active] 315730003363 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 315730003364 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 315730003365 Spore germination protein; Region: Spore_permease; cl17796 315730003366 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 315730003367 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 315730003368 tetrameric interface [polypeptide binding]; other site 315730003369 activator binding site; other site 315730003370 NADP binding site [chemical binding]; other site 315730003371 substrate binding site [chemical binding]; other site 315730003372 catalytic residues [active] 315730003373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730003374 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315730003375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730003376 Walker A/P-loop; other site 315730003377 ATP binding site [chemical binding]; other site 315730003378 Q-loop/lid; other site 315730003379 ABC transporter signature motif; other site 315730003380 Walker B; other site 315730003381 D-loop; other site 315730003382 H-loop/switch region; other site 315730003383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730003384 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 315730003385 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730003386 Walker A/P-loop; other site 315730003387 ATP binding site [chemical binding]; other site 315730003388 Q-loop/lid; other site 315730003389 ABC transporter signature motif; other site 315730003390 Walker B; other site 315730003391 D-loop; other site 315730003392 H-loop/switch region; other site 315730003393 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730003394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730003395 substrate binding pocket [chemical binding]; other site 315730003396 membrane-bound complex binding site; other site 315730003397 hinge residues; other site 315730003398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003400 dimer interface [polypeptide binding]; other site 315730003401 conserved gate region; other site 315730003402 putative PBP binding loops; other site 315730003403 ABC-ATPase subunit interface; other site 315730003404 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730003405 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315730003406 Walker A/P-loop; other site 315730003407 ATP binding site [chemical binding]; other site 315730003408 Q-loop/lid; other site 315730003409 ABC transporter signature motif; other site 315730003410 Walker B; other site 315730003411 D-loop; other site 315730003412 H-loop/switch region; other site 315730003413 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730003414 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 315730003415 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 315730003416 Protein of unknown function (DUF445); Region: DUF445; pfam04286 315730003417 hypothetical protein; Provisional; Region: PRK13676 315730003418 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 315730003419 acetolactate synthase; Reviewed; Region: PRK08617 315730003420 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730003421 PYR/PP interface [polypeptide binding]; other site 315730003422 dimer interface [polypeptide binding]; other site 315730003423 TPP binding site [chemical binding]; other site 315730003424 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315730003425 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 315730003426 TPP-binding site [chemical binding]; other site 315730003427 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 315730003428 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730003429 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730003430 putative metal binding site; other site 315730003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730003432 binding surface 315730003433 TPR motif; other site 315730003434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315730003435 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 315730003436 Probable Catalytic site; other site 315730003437 metal-binding site 315730003438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730003439 S-adenosylmethionine binding site [chemical binding]; other site 315730003440 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 315730003441 active site 315730003442 DNA binding site [nucleotide binding] 315730003443 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 315730003444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730003445 active site 315730003446 motif I; other site 315730003447 motif II; other site 315730003448 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730003449 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 315730003450 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003451 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003452 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003453 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003454 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003455 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003456 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003457 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003458 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003459 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730003460 amidase catalytic site [active] 315730003461 Zn binding residues [ion binding]; other site 315730003462 substrate binding site [chemical binding]; other site 315730003463 S-layer homology domain; Region: SLH; pfam00395 315730003464 S-layer homology domain; Region: SLH; pfam00395 315730003465 S-layer homology domain; Region: SLH; pfam00395 315730003466 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 315730003467 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315730003468 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730003469 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 315730003470 acyl-activating enzyme (AAE) consensus motif; other site 315730003471 acyl-activating enzyme (AAE) consensus motif; other site 315730003472 putative AMP binding site [chemical binding]; other site 315730003473 putative active site [active] 315730003474 putative CoA binding site [chemical binding]; other site 315730003475 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315730003476 Sulfate transporter family; Region: Sulfate_transp; pfam00916 315730003477 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315730003478 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730003479 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730003480 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 315730003481 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 315730003482 S-layer homology domain; Region: SLH; pfam00395 315730003483 S-layer homology domain; Region: SLH; pfam00395 315730003484 S-layer homology domain; Region: SLH; pfam00395 315730003485 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 315730003486 enoyl-CoA hydratase; Provisional; Region: PRK07659 315730003487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730003488 substrate binding site [chemical binding]; other site 315730003489 oxyanion hole (OAH) forming residues; other site 315730003490 trimer interface [polypeptide binding]; other site 315730003491 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 315730003492 metal binding site [ion binding]; metal-binding site 315730003493 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730003494 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 315730003495 putative oligomer interface [polypeptide binding]; other site 315730003496 putative active site [active] 315730003497 metal binding site [ion binding]; metal-binding site 315730003498 S-layer homology domain; Region: SLH; pfam00395 315730003499 S-layer homology domain; Region: SLH; pfam00395 315730003500 S-layer homology domain; Region: SLH; pfam00395 315730003501 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730003502 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730003503 active site 315730003504 metal binding site [ion binding]; metal-binding site 315730003505 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 315730003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730003507 S-adenosylmethionine binding site [chemical binding]; other site 315730003508 DinB family; Region: DinB; cl17821 315730003509 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315730003510 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 315730003511 carbon starvation induced protein; Validated; Region: PRK02963 315730003512 substrate binding pocket [chemical binding]; other site 315730003513 active site 315730003514 iron coordination sites [ion binding]; other site 315730003515 Predicted dehydrogenase [General function prediction only]; Region: COG0579 315730003516 hydroxyglutarate oxidase; Provisional; Region: PRK11728 315730003517 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 315730003518 putative metal binding site [ion binding]; other site 315730003519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003520 proline racemase; Provisional; Region: PRK13969 315730003521 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730003522 ornithine cyclodeaminase; Validated; Region: PRK08618 315730003523 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315730003524 NAD(P) binding site [chemical binding]; other site 315730003525 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315730003526 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730003527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730003528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003529 dimer interface [polypeptide binding]; other site 315730003530 conserved gate region; other site 315730003531 putative PBP binding loops; other site 315730003532 ABC-ATPase subunit interface; other site 315730003533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730003534 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730003535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003536 dimer interface [polypeptide binding]; other site 315730003537 conserved gate region; other site 315730003538 putative PBP binding loops; other site 315730003539 ABC-ATPase subunit interface; other site 315730003540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730003541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730003542 Walker A/P-loop; other site 315730003543 ATP binding site [chemical binding]; other site 315730003544 Q-loop/lid; other site 315730003545 ABC transporter signature motif; other site 315730003546 Walker B; other site 315730003547 D-loop; other site 315730003548 H-loop/switch region; other site 315730003549 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315730003550 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 315730003551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730003552 Walker A/P-loop; other site 315730003553 ATP binding site [chemical binding]; other site 315730003554 Q-loop/lid; other site 315730003555 ABC transporter signature motif; other site 315730003556 Walker B; other site 315730003557 D-loop; other site 315730003558 H-loop/switch region; other site 315730003559 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 315730003560 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315730003561 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 315730003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003563 putative substrate translocation pore; other site 315730003564 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315730003565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730003566 putative active site [active] 315730003567 heme pocket [chemical binding]; other site 315730003568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003569 ATP binding site [chemical binding]; other site 315730003570 Mg2+ binding site [ion binding]; other site 315730003571 G-X-G motif; other site 315730003572 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315730003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003574 active site 315730003575 phosphorylation site [posttranslational modification] 315730003576 intermolecular recognition site; other site 315730003577 dimerization interface [polypeptide binding]; other site 315730003578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 315730003579 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730003580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730003581 non-specific DNA binding site [nucleotide binding]; other site 315730003582 salt bridge; other site 315730003583 sequence-specific DNA binding site [nucleotide binding]; other site 315730003584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730003585 active site 315730003586 DNA binding site [nucleotide binding] 315730003587 Int/Topo IB signature motif; other site 315730003588 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315730003589 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 315730003590 cofactor binding site; other site 315730003591 DNA binding site [nucleotide binding] 315730003592 substrate interaction site [chemical binding]; other site 315730003593 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 315730003594 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 315730003595 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 315730003596 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 315730003597 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730003598 active site 315730003599 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315730003600 Tic20-like protein; Region: Tic20; pfam09685 315730003601 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730003602 DNA binding residues [nucleotide binding] 315730003603 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730003604 dimer interface [polypeptide binding]; other site 315730003605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 315730003606 metal binding site [ion binding]; metal-binding site 315730003607 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315730003608 replicative DNA helicase; Provisional; Region: PRK06749 315730003609 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730003610 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730003611 Walker A motif; other site 315730003612 ATP binding site [chemical binding]; other site 315730003613 Walker B motif; other site 315730003614 DNA binding loops [nucleotide binding] 315730003615 Predicted transcriptional regulators [Transcription]; Region: COG1378 315730003616 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 315730003617 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730003618 C-terminal domain interface [polypeptide binding]; other site 315730003619 sugar binding site [chemical binding]; other site 315730003620 hypothetical protein; Provisional; Region: PRK10621 315730003621 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730003622 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730003623 EamA-like transporter family; Region: EamA; pfam00892 315730003624 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 315730003625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003626 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315730003627 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 315730003628 putative active site [active] 315730003629 putative FMN binding site [chemical binding]; other site 315730003630 putative substrate binding site [chemical binding]; other site 315730003631 putative catalytic residue [active] 315730003632 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 315730003633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730003634 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 315730003635 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730003636 putative NAD(P) binding site [chemical binding]; other site 315730003637 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 315730003638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730003639 NAD(P) binding site [chemical binding]; other site 315730003640 active site 315730003641 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 315730003642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003645 putative substrate translocation pore; other site 315730003646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003647 Predicted permease; Region: DUF318; cl17795 315730003648 Predicted permease; Region: DUF318; cl17795 315730003649 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730003650 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730003651 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315730003652 MarR family; Region: MarR_2; pfam12802 315730003653 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 315730003654 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 315730003655 ATP synthase I chain; Region: ATP_synt_I; pfam03899 315730003656 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315730003657 YolD-like protein; Region: YolD; pfam08863 315730003658 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 315730003659 putative RNAase interaction site [polypeptide binding]; other site 315730003660 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 315730003661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730003662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003663 putative substrate translocation pore; other site 315730003664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730003665 putative DNA binding site [nucleotide binding]; other site 315730003666 dimerization interface [polypeptide binding]; other site 315730003667 putative Zn2+ binding site [ion binding]; other site 315730003668 VanZ like family; Region: VanZ; pfam04892 315730003669 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 315730003670 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 315730003671 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 315730003672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003673 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730003674 dihydroxyacetone kinase; Provisional; Region: PRK14479 315730003675 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 315730003676 DAK2 domain; Region: Dak2; pfam02734 315730003677 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 315730003678 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 315730003679 active site 315730003680 dimer interface [polypeptide binding]; other site 315730003681 non-prolyl cis peptide bond; other site 315730003682 insertion regions; other site 315730003683 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315730003684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730003685 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 315730003686 S-layer homology domain; Region: SLH; pfam00395 315730003687 S-layer homology domain; Region: SLH; pfam00395 315730003688 S-layer homology domain; Region: SLH; pfam00395 315730003689 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 315730003690 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730003691 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730003692 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 315730003693 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 315730003694 active site 315730003695 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 315730003696 nudix motif; other site 315730003697 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730003698 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730003699 putative active site [active] 315730003700 catalytic site [active] 315730003701 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730003702 PLD-like domain; Region: PLDc_2; pfam13091 315730003703 putative active site [active] 315730003704 catalytic site [active] 315730003705 Uncharacterized conserved protein [Function unknown]; Region: COG5276 315730003706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730003707 Erythromycin esterase; Region: Erythro_esteras; cl17110 315730003708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730003709 MarR family; Region: MarR_2; pfam12802 315730003710 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315730003711 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 315730003712 Heat induced stress protein YflT; Region: YflT; pfam11181 315730003713 Predicted membrane protein [Function unknown]; Region: COG2261 315730003714 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 315730003715 anti sigma factor interaction site; other site 315730003716 regulatory phosphorylation site [posttranslational modification]; other site 315730003717 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315730003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003719 ATP binding site [chemical binding]; other site 315730003720 Mg2+ binding site [ion binding]; other site 315730003721 G-X-G motif; other site 315730003722 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 315730003723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730003724 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730003725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730003726 DNA binding residues [nucleotide binding] 315730003727 Ferritin-like domain; Region: Ferritin; pfam00210 315730003728 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 315730003729 dinuclear metal binding motif [ion binding]; other site 315730003730 Response regulator receiver domain; Region: Response_reg; pfam00072 315730003731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003732 active site 315730003733 phosphorylation site [posttranslational modification] 315730003734 intermolecular recognition site; other site 315730003735 dimerization interface [polypeptide binding]; other site 315730003736 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 315730003737 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315730003738 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315730003739 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 315730003740 CHASE3 domain; Region: CHASE3; pfam05227 315730003741 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 315730003742 GAF domain; Region: GAF; pfam01590 315730003743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730003744 dimer interface [polypeptide binding]; other site 315730003745 phosphorylation site [posttranslational modification] 315730003746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003747 ATP binding site [chemical binding]; other site 315730003748 Mg2+ binding site [ion binding]; other site 315730003749 G-X-G motif; other site 315730003750 Response regulator receiver domain; Region: Response_reg; pfam00072 315730003751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003752 active site 315730003753 phosphorylation site [posttranslational modification] 315730003754 intermolecular recognition site; other site 315730003755 dimerization interface [polypeptide binding]; other site 315730003756 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 315730003757 hypothetical protein; Provisional; Region: PRK12856 315730003758 cyanate transporter; Region: CynX; TIGR00896 315730003759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003760 putative substrate translocation pore; other site 315730003761 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315730003762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730003763 DNA-binding site [nucleotide binding]; DNA binding site 315730003764 FCD domain; Region: FCD; pfam07729 315730003765 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730003766 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 315730003767 NADP binding site [chemical binding]; other site 315730003768 dimer interface [polypeptide binding]; other site 315730003769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730003770 Histidine kinase; Region: HisKA_3; pfam07730 315730003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003772 ATP binding site [chemical binding]; other site 315730003773 Mg2+ binding site [ion binding]; other site 315730003774 G-X-G motif; other site 315730003775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730003776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003777 active site 315730003778 phosphorylation site [posttranslational modification] 315730003779 intermolecular recognition site; other site 315730003780 dimerization interface [polypeptide binding]; other site 315730003781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730003782 DNA binding residues [nucleotide binding] 315730003783 dimerization interface [polypeptide binding]; other site 315730003784 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315730003785 YhzD-like protein; Region: YhzD; pfam14120 315730003786 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315730003787 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730003788 active site 315730003789 metal binding site [ion binding]; metal-binding site 315730003790 DNA binding site [nucleotide binding] 315730003791 AAA domain; Region: AAA_27; pfam13514 315730003792 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 315730003793 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 315730003794 generic binding surface II; other site 315730003795 generic binding surface I; other site 315730003796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730003797 Zn2+ binding site [ion binding]; other site 315730003798 Mg2+ binding site [ion binding]; other site 315730003799 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730003800 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730003801 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 315730003802 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730003803 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730003804 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 315730003805 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 315730003806 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730003807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003808 Zn binding site [ion binding]; other site 315730003809 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730003810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003811 Zn binding site [ion binding]; other site 315730003812 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730003813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003814 Zn binding site [ion binding]; other site 315730003815 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730003816 Zn binding site [ion binding]; other site 315730003817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730003818 binding surface 315730003819 TPR motif; other site 315730003820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730003821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730003822 TPR motif; other site 315730003823 binding surface 315730003824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730003825 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 315730003826 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 315730003827 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003828 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003829 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 315730003830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730003831 non-specific DNA binding site [nucleotide binding]; other site 315730003832 salt bridge; other site 315730003833 sequence-specific DNA binding site [nucleotide binding]; other site 315730003834 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 315730003835 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 315730003836 amphipathic channel; other site 315730003837 Asn-Pro-Ala signature motifs; other site 315730003838 glycerol kinase; Provisional; Region: glpK; PRK00047 315730003839 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 315730003840 N- and C-terminal domain interface [polypeptide binding]; other site 315730003841 active site 315730003842 MgATP binding site [chemical binding]; other site 315730003843 catalytic site [active] 315730003844 metal binding site [ion binding]; metal-binding site 315730003845 glycerol binding site [chemical binding]; other site 315730003846 homotetramer interface [polypeptide binding]; other site 315730003847 homodimer interface [polypeptide binding]; other site 315730003848 FBP binding site [chemical binding]; other site 315730003849 protein IIAGlc interface [polypeptide binding]; other site 315730003850 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 315730003851 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730003852 Transcriptional regulator PadR-like family; Region: PadR; cl17335 315730003853 VanZ like family; Region: VanZ; cl01971 315730003854 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 315730003855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730003856 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730003857 DNA binding residues [nucleotide binding] 315730003858 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 315730003859 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730003860 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 315730003861 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 315730003862 Part of AAA domain; Region: AAA_19; pfam13245 315730003863 Family description; Region: UvrD_C_2; pfam13538 315730003864 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 315730003865 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 315730003866 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 315730003867 transcriptional regulator Hpr; Provisional; Region: PRK13777 315730003868 MarR family; Region: MarR; pfam01047 315730003869 YtxH-like protein; Region: YtxH; cl02079 315730003870 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 315730003871 HIT family signature motif; other site 315730003872 catalytic residue [active] 315730003873 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730003874 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730003875 Walker A/P-loop; other site 315730003876 ATP binding site [chemical binding]; other site 315730003877 Q-loop/lid; other site 315730003878 ABC transporter signature motif; other site 315730003879 Walker B; other site 315730003880 D-loop; other site 315730003881 H-loop/switch region; other site 315730003882 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 315730003883 EcsC protein family; Region: EcsC; pfam12787 315730003884 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315730003885 Cysteine-rich domain; Region: CCG; pfam02754 315730003886 Cysteine-rich domain; Region: CCG; pfam02754 315730003887 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 315730003888 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 315730003889 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315730003890 Uncharacterized conserved protein [Function unknown]; Region: COG1556 315730003891 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 315730003892 nucleophilic elbow; other site 315730003893 catalytic triad; other site 315730003894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003896 Uncharacterized conserved protein [Function unknown]; Region: COG3402 315730003897 Predicted membrane protein [Function unknown]; Region: COG3428 315730003898 Bacterial PH domain; Region: DUF304; pfam03703 315730003899 Bacterial PH domain; Region: DUF304; pfam03703 315730003900 Bacterial PH domain; Region: DUF304; pfam03703 315730003901 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730003902 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 315730003903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003905 Collagen binding domain; Region: Collagen_bind; pfam05737 315730003906 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 315730003907 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003908 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003909 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003910 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003911 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315730003912 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003913 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003914 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003915 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003916 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003917 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003918 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003919 Cna protein B-type domain; Region: Cna_B; pfam05738 315730003920 Uncharacterized conserved protein [Function unknown]; Region: COG3402 315730003921 Predicted membrane protein [Function unknown]; Region: COG3428 315730003922 Bacterial PH domain; Region: DUF304; pfam03703 315730003923 Bacterial PH domain; Region: DUF304; pfam03703 315730003924 Bacterial PH domain; Region: DUF304; pfam03703 315730003925 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 315730003926 Transglycosylase; Region: Transgly; pfam00912 315730003927 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730003928 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730003929 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 315730003930 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 315730003931 substrate binding site [chemical binding]; other site 315730003932 active site 315730003933 ferrochelatase; Provisional; Region: PRK12435 315730003934 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 315730003935 C-terminal domain interface [polypeptide binding]; other site 315730003936 active site 315730003937 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 315730003938 active site 315730003939 N-terminal domain interface [polypeptide binding]; other site 315730003940 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 315730003941 Fn3 associated; Region: Fn3_assoc; pfam13287 315730003942 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 315730003943 generic binding surface I; other site 315730003944 generic binding surface II; other site 315730003945 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 315730003946 putative active site [active] 315730003947 putative catalytic site [active] 315730003948 putative Mg binding site IVb [ion binding]; other site 315730003949 putative phosphate binding site [ion binding]; other site 315730003950 putative DNA binding site [nucleotide binding]; other site 315730003951 putative Mg binding site IVa [ion binding]; other site 315730003952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730003954 Predicted membrane protein [Function unknown]; Region: COG1511 315730003955 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730003956 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003957 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003958 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003959 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003960 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 315730003961 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 315730003962 Yip1 domain; Region: Yip1; pfam04893 315730003963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730003965 Coenzyme A binding pocket [chemical binding]; other site 315730003966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730003967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730003968 DNA binding site [nucleotide binding] 315730003969 domain linker motif; other site 315730003970 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730003971 putative dimerization interface [polypeptide binding]; other site 315730003972 putative ligand binding site [chemical binding]; other site 315730003973 YhfH-like protein; Region: YhfH; pfam14149 315730003974 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 315730003975 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315730003976 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 315730003977 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 315730003978 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 315730003979 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 315730003980 acyl-activating enzyme (AAE) consensus motif; other site 315730003981 putative active site [active] 315730003982 putative AMP binding site [chemical binding]; other site 315730003983 putative CoA binding site [chemical binding]; other site 315730003984 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730003985 heme-binding site [chemical binding]; other site 315730003986 S-layer homology domain; Region: SLH; pfam00395 315730003987 S-layer homology domain; Region: SLH; pfam00395 315730003988 S-layer homology domain; Region: SLH; pfam00395 315730003989 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730003990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730003991 substrate binding pocket [chemical binding]; other site 315730003992 membrane-bound complex binding site; other site 315730003993 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 315730003994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003995 dimer interface [polypeptide binding]; other site 315730003996 conserved gate region; other site 315730003997 putative PBP binding loops; other site 315730003998 ABC-ATPase subunit interface; other site 315730003999 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 315730004000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004001 dimer interface [polypeptide binding]; other site 315730004002 conserved gate region; other site 315730004003 putative PBP binding loops; other site 315730004004 ABC-ATPase subunit interface; other site 315730004005 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 315730004006 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 315730004007 Walker A/P-loop; other site 315730004008 ATP binding site [chemical binding]; other site 315730004009 Q-loop/lid; other site 315730004010 ABC transporter signature motif; other site 315730004011 Walker B; other site 315730004012 D-loop; other site 315730004013 H-loop/switch region; other site 315730004014 TOBE-like domain; Region: TOBE_3; pfam12857 315730004015 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730004016 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730004017 putative active site [active] 315730004018 putative metal binding site [ion binding]; other site 315730004019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730004020 Zn2+ binding site [ion binding]; other site 315730004021 Mg2+ binding site [ion binding]; other site 315730004022 Putative zinc-finger; Region: zf-HC2; pfam13490 315730004023 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730004024 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730004025 RNA polymerase sigma factor; Provisional; Region: PRK12541 315730004026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730004027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730004028 DNA binding residues [nucleotide binding] 315730004029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730004030 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730004031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730004032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 315730004033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730004034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004035 dimer interface [polypeptide binding]; other site 315730004036 phosphorylation site [posttranslational modification] 315730004037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004038 ATP binding site [chemical binding]; other site 315730004039 Mg2+ binding site [ion binding]; other site 315730004040 G-X-G motif; other site 315730004041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730004042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004043 active site 315730004044 phosphorylation site [posttranslational modification] 315730004045 intermolecular recognition site; other site 315730004046 dimerization interface [polypeptide binding]; other site 315730004047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730004048 DNA binding site [nucleotide binding] 315730004049 CAAX protease self-immunity; Region: Abi; pfam02517 315730004050 Peptidase family M48; Region: Peptidase_M48; pfam01435 315730004051 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 315730004052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730004053 dimerization interface [polypeptide binding]; other site 315730004054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730004055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730004056 dimer interface [polypeptide binding]; other site 315730004057 putative CheW interface [polypeptide binding]; other site 315730004058 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730004059 EamA-like transporter family; Region: EamA; pfam00892 315730004060 EamA-like transporter family; Region: EamA; pfam00892 315730004061 S-layer homology domain; Region: SLH; pfam00395 315730004062 S-layer homology domain; Region: SLH; pfam00395 315730004063 S-layer homology domain; Region: SLH; pfam00395 315730004064 S-layer homology domain; Region: SLH; pfam00395 315730004065 S-layer homology domain; Region: SLH; pfam00395 315730004066 S-layer homology domain; Region: SLH; pfam00395 315730004067 malate synthase A; Region: malate_syn_A; TIGR01344 315730004068 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 315730004069 active site 315730004070 isocitrate lyase; Provisional; Region: PRK15063 315730004071 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315730004072 tetramer interface [polypeptide binding]; other site 315730004073 active site 315730004074 Mg2+/Mn2+ binding site [ion binding]; other site 315730004075 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730004076 DNA-binding site [nucleotide binding]; DNA binding site 315730004077 RNA-binding motif; other site 315730004078 ComK protein; Region: ComK; pfam06338 315730004079 Uncharacterized conserved protein [Function unknown]; Region: COG0398 315730004080 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730004081 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730004082 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730004083 Catalytic site [active] 315730004084 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730004085 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 315730004086 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 315730004087 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 315730004088 Part of AAA domain; Region: AAA_19; pfam13245 315730004089 Family description; Region: UvrD_C_2; pfam13538 315730004090 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 315730004091 hypothetical protein; Provisional; Region: PRK07758 315730004092 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 315730004093 A new structural DNA glycosylase; Region: AlkD_like; cd06561 315730004094 active site 315730004095 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730004096 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 315730004097 Spore germination protein GerPC; Region: GerPC; pfam10737 315730004098 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 315730004099 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730004100 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730004101 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 315730004102 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 315730004103 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 315730004104 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730004105 inhibitor-cofactor binding pocket; inhibition site 315730004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004107 catalytic residue [active] 315730004108 hypothetical protein; Provisional; Region: PRK13673 315730004109 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 315730004110 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730004111 active site 315730004112 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730004113 dimer interface [polypeptide binding]; other site 315730004114 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730004115 Ligand Binding Site [chemical binding]; other site 315730004116 Molecular Tunnel; other site 315730004117 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315730004118 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315730004119 tetramer interface [polypeptide binding]; other site 315730004120 heme binding pocket [chemical binding]; other site 315730004121 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 315730004122 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 315730004123 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 315730004124 active site 315730004125 catalytic site [active] 315730004126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 315730004127 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 315730004128 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 315730004129 S1 domain; Region: S1_2; pfam13509 315730004130 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 315730004131 homodimer interface [polypeptide binding]; other site 315730004132 putative substrate binding pocket [chemical binding]; other site 315730004133 diiron center [ion binding]; other site 315730004134 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 315730004135 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 315730004136 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 315730004137 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730004138 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730004139 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730004140 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 315730004141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730004142 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730004143 active site 315730004144 motif I; other site 315730004145 motif II; other site 315730004146 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730004147 YjzC-like protein; Region: YjzC; pfam14168 315730004148 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 315730004149 Clp amino terminal domain; Region: Clp_N; pfam02861 315730004150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730004151 Walker A motif; other site 315730004152 ATP binding site [chemical binding]; other site 315730004153 Walker B motif; other site 315730004154 arginine finger; other site 315730004155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730004156 Walker A motif; other site 315730004157 ATP binding site [chemical binding]; other site 315730004158 Walker B motif; other site 315730004159 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 315730004160 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 315730004161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730004162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730004163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004164 ComZ; Region: ComZ; pfam10815 315730004165 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 315730004166 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315730004167 dimer interface [polypeptide binding]; other site 315730004168 active site 315730004169 CoA binding pocket [chemical binding]; other site 315730004170 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 315730004171 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 315730004172 dimer interface [polypeptide binding]; other site 315730004173 active site 315730004174 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 315730004175 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 315730004176 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315730004177 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315730004178 active site 315730004179 HIGH motif; other site 315730004180 dimer interface [polypeptide binding]; other site 315730004181 KMSKS motif; other site 315730004182 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 315730004183 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730004184 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730004185 peptide binding site [polypeptide binding]; other site 315730004186 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004188 dimer interface [polypeptide binding]; other site 315730004189 conserved gate region; other site 315730004190 putative PBP binding loops; other site 315730004191 ABC-ATPase subunit interface; other site 315730004192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730004193 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730004194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004195 dimer interface [polypeptide binding]; other site 315730004196 conserved gate region; other site 315730004197 putative PBP binding loops; other site 315730004198 ABC-ATPase subunit interface; other site 315730004199 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730004200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730004201 Walker A/P-loop; other site 315730004202 ATP binding site [chemical binding]; other site 315730004203 Q-loop/lid; other site 315730004204 ABC transporter signature motif; other site 315730004205 Walker B; other site 315730004206 D-loop; other site 315730004207 H-loop/switch region; other site 315730004208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730004209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730004210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 315730004211 Walker A/P-loop; other site 315730004212 ATP binding site [chemical binding]; other site 315730004213 Q-loop/lid; other site 315730004214 ABC transporter signature motif; other site 315730004215 Walker B; other site 315730004216 D-loop; other site 315730004217 H-loop/switch region; other site 315730004218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730004219 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730004220 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 315730004221 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730004222 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730004223 peptide binding site [polypeptide binding]; other site 315730004224 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315730004225 ArsC family; Region: ArsC; pfam03960 315730004226 putative catalytic residues [active] 315730004227 thiol/disulfide switch; other site 315730004228 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 315730004229 adaptor protein; Provisional; Region: PRK02315 315730004230 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315730004231 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315730004232 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730004233 putative active site [active] 315730004234 catalytic site [active] 315730004235 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730004236 putative active site [active] 315730004237 catalytic site [active] 315730004238 Competence protein CoiA-like family; Region: CoiA; cl11541 315730004239 oligoendopeptidase F; Region: pepF; TIGR00181 315730004240 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315730004241 active site 315730004242 Zn binding site [ion binding]; other site 315730004243 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315730004244 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315730004245 catalytic residues [active] 315730004246 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 315730004247 apolar tunnel; other site 315730004248 heme binding site [chemical binding]; other site 315730004249 dimerization interface [polypeptide binding]; other site 315730004250 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 315730004251 putative active site [active] 315730004252 putative metal binding residues [ion binding]; other site 315730004253 signature motif; other site 315730004254 putative triphosphate binding site [ion binding]; other site 315730004255 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730004256 synthetase active site [active] 315730004257 NTP binding site [chemical binding]; other site 315730004258 metal binding site [ion binding]; metal-binding site 315730004259 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 315730004260 ATP-NAD kinase; Region: NAD_kinase; pfam01513 315730004261 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315730004262 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315730004263 active site 315730004264 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 315730004265 trimer interface [polypeptide binding]; other site 315730004266 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 315730004267 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 315730004268 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 315730004269 active site 315730004270 metal binding site [ion binding]; metal-binding site 315730004271 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 315730004272 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315730004273 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 315730004274 active site 315730004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004276 S-adenosylmethionine binding site [chemical binding]; other site 315730004277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 315730004278 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730004279 putative metal binding site; other site 315730004280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730004281 binding surface 315730004282 TPR motif; other site 315730004283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730004284 binding surface 315730004285 TPR motif; other site 315730004286 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730004287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004288 S-adenosylmethionine binding site [chemical binding]; other site 315730004289 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 315730004290 catalytic residues [active] 315730004291 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315730004292 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315730004293 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 315730004294 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 315730004295 substrate binding site; other site 315730004296 tetramer interface; other site 315730004297 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 315730004298 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 315730004299 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315730004300 NAD binding site [chemical binding]; other site 315730004301 substrate binding site [chemical binding]; other site 315730004302 homodimer interface [polypeptide binding]; other site 315730004303 active site 315730004304 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 315730004305 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 315730004306 NADP binding site [chemical binding]; other site 315730004307 active site 315730004308 putative substrate binding site [chemical binding]; other site 315730004309 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 315730004310 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 315730004311 NAD binding site [chemical binding]; other site 315730004312 homotetramer interface [polypeptide binding]; other site 315730004313 homodimer interface [polypeptide binding]; other site 315730004314 substrate binding site [chemical binding]; other site 315730004315 active site 315730004316 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 315730004317 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315730004318 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 315730004319 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315730004320 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 315730004321 Part of AAA domain; Region: AAA_19; pfam13245 315730004322 Family description; Region: UvrD_C_2; pfam13538 315730004323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 315730004324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004325 Coenzyme A binding pocket [chemical binding]; other site 315730004326 hypothetical protein; Provisional; Region: PRK13679 315730004327 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730004328 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315730004329 Putative esterase; Region: Esterase; pfam00756 315730004330 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730004331 EamA-like transporter family; Region: EamA; pfam00892 315730004332 EamA-like transporter family; Region: EamA; pfam00892 315730004333 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315730004334 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730004335 ligand binding site [chemical binding]; other site 315730004336 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 315730004337 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730004338 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 315730004339 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 315730004340 Na binding site [ion binding]; other site 315730004341 anthranilate synthase component I; Provisional; Region: PRK13570 315730004342 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315730004343 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 315730004344 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315730004345 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315730004346 glutamine binding [chemical binding]; other site 315730004347 catalytic triad [active] 315730004348 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 315730004349 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730004350 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730004351 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 315730004352 active site 315730004353 ribulose/triose binding site [chemical binding]; other site 315730004354 phosphate binding site [ion binding]; other site 315730004355 substrate (anthranilate) binding pocket [chemical binding]; other site 315730004356 product (indole) binding pocket [chemical binding]; other site 315730004357 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 315730004358 active site 315730004359 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 315730004360 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 315730004361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004362 catalytic residue [active] 315730004363 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 315730004364 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 315730004365 substrate binding site [chemical binding]; other site 315730004366 active site 315730004367 catalytic residues [active] 315730004368 heterodimer interface [polypeptide binding]; other site 315730004369 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 315730004370 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 315730004371 L-lactate permease; Region: Lactate_perm; cl00701 315730004372 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 315730004373 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 315730004374 Double zinc ribbon; Region: DZR; pfam12773 315730004375 Predicted membrane protein [Function unknown]; Region: COG4640 315730004376 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 315730004377 YARHG domain; Region: YARHG; pfam13308 315730004378 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 315730004379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730004380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730004381 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730004382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004383 Coenzyme A binding pocket [chemical binding]; other site 315730004384 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 315730004385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004387 S-adenosylmethionine binding site [chemical binding]; other site 315730004388 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 315730004389 NADPH bind site [chemical binding]; other site 315730004390 putative FMN binding site [chemical binding]; other site 315730004391 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 315730004392 putative FMN binding site [chemical binding]; other site 315730004393 NADPH bind site [chemical binding]; other site 315730004394 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 315730004395 YcaO-like family; Region: YcaO; pfam02624 315730004396 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 315730004397 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 315730004398 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 315730004399 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 315730004400 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730004401 E3 interaction surface; other site 315730004402 lipoyl attachment site [posttranslational modification]; other site 315730004403 e3 binding domain; Region: E3_binding; pfam02817 315730004404 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315730004405 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 315730004406 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 315730004407 TPP-binding site [chemical binding]; other site 315730004408 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 315730004409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730004410 salt bridge; other site 315730004411 non-specific DNA binding site [nucleotide binding]; other site 315730004412 sequence-specific DNA binding site [nucleotide binding]; other site 315730004413 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315730004414 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 315730004415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730004416 non-specific DNA binding site [nucleotide binding]; other site 315730004417 salt bridge; other site 315730004418 sequence-specific DNA binding site [nucleotide binding]; other site 315730004419 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730004420 active site 315730004421 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 315730004422 HNH endonuclease; Region: HNH_2; pfam13391 315730004423 Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174 315730004424 PLD-like domain; Region: PLDc_2; pfam13091 315730004425 putative active site [active] 315730004426 catalytic site [active] 315730004427 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730004428 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730004429 catalytic residues [active] 315730004430 catalytic nucleophile [active] 315730004431 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730004432 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730004433 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730004434 Synaptic Site I dimer interface [polypeptide binding]; other site 315730004435 DNA binding site [nucleotide binding] 315730004436 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 315730004437 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 315730004438 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 315730004439 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315730004440 Int/Topo IB signature motif; other site 315730004441 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 315730004442 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730004443 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730004444 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 315730004445 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 315730004446 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730004447 Catalytic site [active] 315730004448 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 315730004449 Helix-turn-helix domain; Region: HTH_28; pfam13518 315730004450 Winged helix-turn helix; Region: HTH_29; pfam13551 315730004451 putative transposase OrfB; Reviewed; Region: PHA02517 315730004452 HTH-like domain; Region: HTH_21; pfam13276 315730004453 Integrase core domain; Region: rve; pfam00665 315730004454 Integrase core domain; Region: rve_3; pfam13683 315730004455 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 315730004456 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 315730004457 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730004458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730004459 non-specific DNA binding site [nucleotide binding]; other site 315730004460 salt bridge; other site 315730004461 sequence-specific DNA binding site [nucleotide binding]; other site 315730004462 Anti-repressor SinI; Region: SinI; pfam08671 315730004463 Anti-repressor SinI; Region: SinI; pfam08671 315730004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730004465 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 315730004466 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 315730004467 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 315730004468 NAD(P) binding site [chemical binding]; other site 315730004469 catalytic residues [active] 315730004470 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 315730004471 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 315730004472 Walker A/P-loop; other site 315730004473 ATP binding site [chemical binding]; other site 315730004474 Q-loop/lid; other site 315730004475 ABC transporter signature motif; other site 315730004476 Walker B; other site 315730004477 D-loop; other site 315730004478 H-loop/switch region; other site 315730004479 TOBE domain; Region: TOBE_2; pfam08402 315730004480 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 315730004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004482 dimer interface [polypeptide binding]; other site 315730004483 conserved gate region; other site 315730004484 putative PBP binding loops; other site 315730004485 ABC-ATPase subunit interface; other site 315730004486 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 315730004487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004488 dimer interface [polypeptide binding]; other site 315730004489 conserved gate region; other site 315730004490 putative PBP binding loops; other site 315730004491 ABC-ATPase subunit interface; other site 315730004492 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 315730004493 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 315730004494 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315730004495 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315730004496 active site 315730004497 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 315730004498 Protein export membrane protein; Region: SecD_SecF; cl14618 315730004499 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315730004500 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315730004501 active site 315730004502 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 315730004503 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315730004504 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315730004505 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730004506 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315730004507 Cysteine-rich domain; Region: CCG; pfam02754 315730004508 Cysteine-rich domain; Region: CCG; pfam02754 315730004509 FAD binding domain; Region: FAD_binding_4; pfam01565 315730004510 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 315730004511 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315730004512 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315730004513 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730004514 metal binding site [ion binding]; metal-binding site 315730004515 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 315730004516 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 315730004517 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730004518 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730004519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004521 active site 315730004522 phosphorylation site [posttranslational modification] 315730004523 intermolecular recognition site; other site 315730004524 dimerization interface [polypeptide binding]; other site 315730004525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730004526 DNA binding site [nucleotide binding] 315730004527 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730004528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730004529 dimerization interface [polypeptide binding]; other site 315730004530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004531 dimer interface [polypeptide binding]; other site 315730004532 phosphorylation site [posttranslational modification] 315730004533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004534 ATP binding site [chemical binding]; other site 315730004535 Mg2+ binding site [ion binding]; other site 315730004536 G-X-G motif; other site 315730004537 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315730004538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730004539 DNA-binding site [nucleotide binding]; DNA binding site 315730004540 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 315730004541 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315730004542 Cysteine-rich domain; Region: CCG; pfam02754 315730004543 Cysteine-rich domain; Region: CCG; pfam02754 315730004544 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 315730004545 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 315730004546 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315730004547 Uncharacterized conserved protein [Function unknown]; Region: COG1556 315730004548 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 315730004549 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 315730004550 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 315730004551 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 315730004552 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 315730004553 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 315730004554 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004555 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730004556 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 315730004557 dimer interaction site [polypeptide binding]; other site 315730004558 substrate-binding tunnel; other site 315730004559 active site 315730004560 catalytic site [active] 315730004561 substrate binding site [chemical binding]; other site 315730004562 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 315730004563 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 315730004564 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730004565 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 315730004566 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 315730004567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004568 NAD(P) binding site [chemical binding]; other site 315730004569 active site 315730004570 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 315730004571 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 315730004572 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 315730004573 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 315730004574 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730004575 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 315730004576 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004577 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 315730004578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315730004579 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 315730004580 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 315730004581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730004582 Walker A/P-loop; other site 315730004583 ATP binding site [chemical binding]; other site 315730004584 Q-loop/lid; other site 315730004585 ABC transporter signature motif; other site 315730004586 Walker B; other site 315730004587 D-loop; other site 315730004588 H-loop/switch region; other site 315730004589 TOBE domain; Region: TOBE_2; pfam08402 315730004590 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 315730004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004592 dimer interface [polypeptide binding]; other site 315730004593 conserved gate region; other site 315730004594 putative PBP binding loops; other site 315730004595 ABC-ATPase subunit interface; other site 315730004596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004597 dimer interface [polypeptide binding]; other site 315730004598 conserved gate region; other site 315730004599 putative PBP binding loops; other site 315730004600 ABC-ATPase subunit interface; other site 315730004601 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 315730004602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730004603 motif II; other site 315730004604 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 315730004605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730004606 catalytic residue [active] 315730004607 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 315730004608 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730004609 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 315730004610 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315730004611 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730004612 heme-binding site [chemical binding]; other site 315730004613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004614 Leucine rich repeat; Region: LRR_8; pfam13855 315730004615 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 315730004616 Leucine-rich repeats; other site 315730004617 Substrate binding site [chemical binding]; other site 315730004618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004619 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004622 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004623 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004625 LRR adjacent; Region: LRR_adjacent; pfam08191 315730004626 S-layer homology domain; Region: SLH; pfam00395 315730004627 S-layer homology domain; Region: SLH; pfam00395 315730004628 S-layer homology domain; Region: SLH; pfam00395 315730004629 hypothetical protein; Validated; Region: PRK06755 315730004630 active site 315730004631 intersubunit interface [polypeptide binding]; other site 315730004632 Zn2+ binding site [ion binding]; other site 315730004633 FOG: CBS domain [General function prediction only]; Region: COG0517 315730004634 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 315730004635 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 315730004636 NodB motif; other site 315730004637 putative active site [active] 315730004638 putative catalytic site [active] 315730004639 Zn binding site [ion binding]; other site 315730004640 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730004641 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 315730004642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004643 dimer interface [polypeptide binding]; other site 315730004644 phosphorylation site [posttranslational modification] 315730004645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004646 ATP binding site [chemical binding]; other site 315730004647 Mg2+ binding site [ion binding]; other site 315730004648 G-X-G motif; other site 315730004649 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730004650 MarR family; Region: MarR; pfam01047 315730004651 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730004652 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730004653 active site 315730004654 Zn binding site [ion binding]; other site 315730004655 DinB superfamily; Region: DinB_2; pfam12867 315730004656 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315730004657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730004658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004659 dimer interface [polypeptide binding]; other site 315730004660 phosphorylation site [posttranslational modification] 315730004661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004662 ATP binding site [chemical binding]; other site 315730004663 Mg2+ binding site [ion binding]; other site 315730004664 G-X-G motif; other site 315730004665 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 315730004666 Ligand Binding Site [chemical binding]; other site 315730004667 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 315730004668 active site 315730004669 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 315730004670 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 315730004671 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 315730004672 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 315730004673 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 315730004674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004675 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730004676 Coenzyme A binding pocket [chemical binding]; other site 315730004677 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 315730004678 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 315730004679 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 315730004680 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 315730004681 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 315730004682 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 315730004683 dimer interface [polypeptide binding]; other site 315730004684 putative radical transfer pathway; other site 315730004685 diiron center [ion binding]; other site 315730004686 tyrosyl radical; other site 315730004687 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315730004688 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730004689 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730004690 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315730004691 NAD(P) binding site [chemical binding]; other site 315730004692 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730004693 hypothetical protein; Validated; Region: PRK06748 315730004694 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730004695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730004696 putative active site [active] 315730004697 heme pocket [chemical binding]; other site 315730004698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730004699 Walker A motif; other site 315730004700 ATP binding site [chemical binding]; other site 315730004701 Walker B motif; other site 315730004702 arginine finger; other site 315730004703 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315730004704 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730004705 tetramerization interface [polypeptide binding]; other site 315730004706 NAD(P) binding site [chemical binding]; other site 315730004707 catalytic residues [active] 315730004708 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 315730004709 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730004710 inhibitor-cofactor binding pocket; inhibition site 315730004711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004712 catalytic residue [active] 315730004713 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730004714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730004715 DNA-binding site [nucleotide binding]; DNA binding site 315730004716 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730004717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730004718 Walker A/P-loop; other site 315730004719 ATP binding site [chemical binding]; other site 315730004720 Q-loop/lid; other site 315730004721 ABC transporter signature motif; other site 315730004722 Walker B; other site 315730004723 D-loop; other site 315730004724 H-loop/switch region; other site 315730004725 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730004726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730004727 Walker A/P-loop; other site 315730004728 ATP binding site [chemical binding]; other site 315730004729 Q-loop/lid; other site 315730004730 ABC transporter signature motif; other site 315730004731 Walker B; other site 315730004732 D-loop; other site 315730004733 H-loop/switch region; other site 315730004734 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315730004735 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315730004736 CAAX protease self-immunity; Region: Abi; pfam02517 315730004737 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315730004738 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 315730004739 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730004740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730004741 putative DNA binding site [nucleotide binding]; other site 315730004742 putative Zn2+ binding site [ion binding]; other site 315730004743 AsnC family; Region: AsnC_trans_reg; pfam01037 315730004744 Uncharacterized conserved protein [Function unknown]; Region: COG2128 315730004745 Isochorismatase family; Region: Isochorismatase; pfam00857 315730004746 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730004747 catalytic triad [active] 315730004748 conserved cis-peptide bond; other site 315730004749 SseB protein; Region: SseB; cl06279 315730004750 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 315730004751 dimer interface [polypeptide binding]; other site 315730004752 catalytic triad [active] 315730004753 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 315730004754 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 315730004755 FMN binding site [chemical binding]; other site 315730004756 substrate binding site [chemical binding]; other site 315730004757 putative catalytic residue [active] 315730004758 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315730004759 DltD N-terminal region; Region: DltD_N; pfam04915 315730004760 DltD central region; Region: DltD_M; pfam04918 315730004761 DltD C-terminal region; Region: DltD_C; pfam04914 315730004762 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 315730004763 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 315730004764 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 315730004765 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 315730004766 acyl-activating enzyme (AAE) consensus motif; other site 315730004767 AMP binding site [chemical binding]; other site 315730004768 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 315730004769 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730004770 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730004771 metal binding site [ion binding]; metal-binding site 315730004772 dimer interface [polypeptide binding]; other site 315730004773 flavodoxin; Provisional; Region: PRK06756 315730004774 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 315730004775 Phosphotransferase enzyme family; Region: APH; pfam01636 315730004776 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315730004777 active site 315730004778 substrate binding site [chemical binding]; other site 315730004779 ATP binding site [chemical binding]; other site 315730004780 multidrug efflux protein; Reviewed; Region: PRK01766 315730004781 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 315730004782 cation binding site [ion binding]; other site 315730004783 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 315730004784 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 315730004785 hydrophobic ligand binding site; other site 315730004786 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730004787 catalytic residues [active] 315730004788 Regulatory protein YrvL; Region: YrvL; pfam14184 315730004789 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730004790 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 315730004791 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730004792 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 315730004793 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 315730004794 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004795 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730004796 hypothetical protein; Provisional; Region: PRK03094 315730004797 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 315730004798 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315730004799 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730004800 homodimer interface [polypeptide binding]; other site 315730004801 substrate-cofactor binding pocket; other site 315730004802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004803 catalytic residue [active] 315730004804 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 315730004805 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730004806 PYR/PP interface [polypeptide binding]; other site 315730004807 dimer interface [polypeptide binding]; other site 315730004808 TPP binding site [chemical binding]; other site 315730004809 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315730004810 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315730004811 TPP-binding site [chemical binding]; other site 315730004812 dimer interface [polypeptide binding]; other site 315730004813 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 315730004814 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315730004815 putative valine binding site [chemical binding]; other site 315730004816 dimer interface [polypeptide binding]; other site 315730004817 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 315730004818 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315730004819 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 315730004820 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315730004821 2-isopropylmalate synthase; Validated; Region: PRK00915 315730004822 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 315730004823 active site 315730004824 catalytic residues [active] 315730004825 metal binding site [ion binding]; metal-binding site 315730004826 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 315730004827 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 315730004828 tartrate dehydrogenase; Region: TTC; TIGR02089 315730004829 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 315730004830 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 315730004831 substrate binding site [chemical binding]; other site 315730004832 ligand binding site [chemical binding]; other site 315730004833 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 315730004834 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 315730004835 substrate binding site [chemical binding]; other site 315730004836 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 315730004837 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 315730004838 dimer interface [polypeptide binding]; other site 315730004839 motif 1; other site 315730004840 active site 315730004841 motif 2; other site 315730004842 motif 3; other site 315730004843 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 315730004844 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 315730004845 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 315730004846 histidinol dehydrogenase; Region: hisD; TIGR00069 315730004847 NAD binding site [chemical binding]; other site 315730004848 dimerization interface [polypeptide binding]; other site 315730004849 product binding site; other site 315730004850 substrate binding site [chemical binding]; other site 315730004851 zinc binding site [ion binding]; other site 315730004852 catalytic residues [active] 315730004853 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 315730004854 putative active site pocket [active] 315730004855 4-fold oligomerization interface [polypeptide binding]; other site 315730004856 metal binding residues [ion binding]; metal-binding site 315730004857 3-fold/trimer interface [polypeptide binding]; other site 315730004858 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 315730004859 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 315730004860 putative active site [active] 315730004861 oxyanion strand; other site 315730004862 catalytic triad [active] 315730004863 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 315730004864 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 315730004865 catalytic residues [active] 315730004866 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 315730004867 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 315730004868 substrate binding site [chemical binding]; other site 315730004869 glutamase interaction surface [polypeptide binding]; other site 315730004870 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 315730004871 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 315730004872 metal binding site [ion binding]; metal-binding site 315730004873 histidinol-phosphatase; Validated; Region: PRK06740 315730004874 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 315730004875 dimer interface [polypeptide binding]; other site 315730004876 active site 315730004877 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 315730004878 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 315730004879 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 315730004880 putative ligand binding site [chemical binding]; other site 315730004881 putative NAD binding site [chemical binding]; other site 315730004882 catalytic site [active] 315730004883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 315730004884 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 315730004885 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730004886 Sulfatase; Region: Sulfatase; pfam00884 315730004887 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730004888 diaminopimelate decarboxylase; Region: lysA; TIGR01048 315730004889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 315730004890 active site 315730004891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730004892 substrate binding site [chemical binding]; other site 315730004893 catalytic residues [active] 315730004894 dimer interface [polypeptide binding]; other site 315730004895 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 315730004896 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 315730004897 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 315730004898 Active Sites [active] 315730004899 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 315730004900 ATP-sulfurylase; Region: ATPS; cd00517 315730004901 active site 315730004902 HXXH motif; other site 315730004903 flexible loop; other site 315730004904 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 315730004905 ligand-binding site [chemical binding]; other site 315730004906 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 315730004907 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730004908 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730004909 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 315730004910 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 315730004911 active site 315730004912 SAM binding site [chemical binding]; other site 315730004913 homodimer interface [polypeptide binding]; other site 315730004914 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 315730004915 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315730004916 putative active site [active] 315730004917 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315730004918 putative active site [active] 315730004919 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 315730004920 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 315730004921 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 315730004922 Na2 binding site [ion binding]; other site 315730004923 putative substrate binding site 1 [chemical binding]; other site 315730004924 Na binding site 1 [ion binding]; other site 315730004925 putative substrate binding site 2 [chemical binding]; other site 315730004926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730004927 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730004928 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730004929 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730004930 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730004931 Protein of unknown function (DUF402); Region: DUF402; cl00979 315730004932 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 315730004933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004934 Coenzyme A binding pocket [chemical binding]; other site 315730004935 Vpu protein; Region: Vpu; pfam00558 315730004936 PspA/IM30 family; Region: PspA_IM30; pfam04012 315730004937 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 315730004938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730004939 Histidine kinase; Region: HisKA_3; pfam07730 315730004940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004941 ATP binding site [chemical binding]; other site 315730004942 Mg2+ binding site [ion binding]; other site 315730004943 G-X-G motif; other site 315730004944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730004945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004946 active site 315730004947 phosphorylation site [posttranslational modification] 315730004948 intermolecular recognition site; other site 315730004949 dimerization interface [polypeptide binding]; other site 315730004950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730004951 DNA binding residues [nucleotide binding] 315730004952 dimerization interface [polypeptide binding]; other site 315730004953 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 315730004954 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315730004955 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004957 S-adenosylmethionine binding site [chemical binding]; other site 315730004958 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 315730004959 Peptidase family M50; Region: Peptidase_M50; pfam02163 315730004960 active site 315730004961 putative substrate binding region [chemical binding]; other site 315730004962 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 315730004963 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 315730004964 heme-binding site [chemical binding]; other site 315730004965 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 315730004966 FAD binding pocket [chemical binding]; other site 315730004967 FAD binding motif [chemical binding]; other site 315730004968 phosphate binding motif [ion binding]; other site 315730004969 beta-alpha-beta structure motif; other site 315730004970 NAD binding pocket [chemical binding]; other site 315730004971 Heme binding pocket [chemical binding]; other site 315730004972 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315730004973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730004974 ligand binding site [chemical binding]; other site 315730004975 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 315730004976 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730004977 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 315730004978 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 315730004979 Transglycosylase; Region: Transgly; pfam00912 315730004980 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730004981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730004982 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 315730004983 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004984 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004985 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004986 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 315730004987 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 315730004988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730004989 putative active site [active] 315730004990 heme pocket [chemical binding]; other site 315730004991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004992 dimer interface [polypeptide binding]; other site 315730004993 phosphorylation site [posttranslational modification] 315730004994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004995 ATP binding site [chemical binding]; other site 315730004996 Mg2+ binding site [ion binding]; other site 315730004997 G-X-G motif; other site 315730004998 Protein of unknown function DUF72; Region: DUF72; pfam01904 315730004999 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 315730005000 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730005001 active site 315730005002 DNA binding site [nucleotide binding] 315730005003 Int/Topo IB signature motif; other site 315730005004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730005005 dimerization interface [polypeptide binding]; other site 315730005006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730005007 dimer interface [polypeptide binding]; other site 315730005008 phosphorylation site [posttranslational modification] 315730005009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005010 ATP binding site [chemical binding]; other site 315730005011 Mg2+ binding site [ion binding]; other site 315730005012 G-X-G motif; other site 315730005013 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 315730005014 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 315730005015 Predicted integral membrane protein [Function unknown]; Region: COG0392 315730005016 Uncharacterized conserved protein [Function unknown]; Region: COG2898 315730005017 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 315730005018 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 315730005019 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730005020 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730005021 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730005022 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730005023 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730005024 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 315730005025 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 315730005026 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 315730005027 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730005028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730005029 RNA binding surface [nucleotide binding]; other site 315730005030 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 315730005031 active site 315730005032 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730005033 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315730005034 catalytic residues [active] 315730005035 Double zinc ribbon; Region: DZR; pfam12773 315730005036 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 315730005037 ResB-like family; Region: ResB; pfam05140 315730005038 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315730005039 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 315730005040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005042 active site 315730005043 phosphorylation site [posttranslational modification] 315730005044 intermolecular recognition site; other site 315730005045 dimerization interface [polypeptide binding]; other site 315730005046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730005047 DNA binding site [nucleotide binding] 315730005048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730005049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730005050 dimerization interface [polypeptide binding]; other site 315730005051 PAS domain; Region: PAS; smart00091 315730005052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730005053 dimer interface [polypeptide binding]; other site 315730005054 phosphorylation site [posttranslational modification] 315730005055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005056 ATP binding site [chemical binding]; other site 315730005057 Mg2+ binding site [ion binding]; other site 315730005058 G-X-G motif; other site 315730005059 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 315730005060 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730005061 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730005062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730005063 Predicted membrane protein [Function unknown]; Region: COG3601 315730005064 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 315730005065 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 315730005066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 315730005067 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730005068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730005069 ATP binding site [chemical binding]; other site 315730005070 putative Mg++ binding site [ion binding]; other site 315730005071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730005072 nucleotide binding region [chemical binding]; other site 315730005073 ATP-binding site [chemical binding]; other site 315730005074 CAAX protease self-immunity; Region: Abi; pfam02517 315730005075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730005076 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730005077 putative active site [active] 315730005078 putative metal binding site [ion binding]; other site 315730005079 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730005080 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 315730005081 DNA binding residues [nucleotide binding] 315730005082 B12 binding domain; Region: B12-binding_2; pfam02607 315730005083 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 315730005084 adaptor protein; Provisional; Region: PRK02899 315730005085 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730005086 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730005087 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315730005088 NAD(P) binding site [chemical binding]; other site 315730005089 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 315730005090 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730005091 amidase catalytic site [active] 315730005092 Zn binding residues [ion binding]; other site 315730005093 substrate binding site [chemical binding]; other site 315730005094 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 315730005095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 315730005096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730005097 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 315730005098 active site 315730005099 homotetramer interface [polypeptide binding]; other site 315730005100 homodimer interface [polypeptide binding]; other site 315730005101 cytidylate kinase; Provisional; Region: cmk; PRK00023 315730005102 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 315730005103 CMP-binding site; other site 315730005104 The sites determining sugar specificity; other site 315730005105 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 315730005106 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 315730005107 RNA binding site [nucleotide binding]; other site 315730005108 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 315730005109 RNA binding site [nucleotide binding]; other site 315730005110 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 315730005111 RNA binding site [nucleotide binding]; other site 315730005112 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 315730005113 RNA binding site [nucleotide binding]; other site 315730005114 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 315730005115 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 315730005116 homotetramer interface [polypeptide binding]; other site 315730005117 FMN binding site [chemical binding]; other site 315730005118 homodimer contacts [polypeptide binding]; other site 315730005119 putative active site [active] 315730005120 putative substrate binding site [chemical binding]; other site 315730005121 YpzI-like protein; Region: YpzI; pfam14140 315730005122 YIEGIA protein; Region: YIEGIA; pfam14045 315730005123 GTP-binding protein Der; Reviewed; Region: PRK00093 315730005124 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 315730005125 G1 box; other site 315730005126 GTP/Mg2+ binding site [chemical binding]; other site 315730005127 Switch I region; other site 315730005128 G2 box; other site 315730005129 Switch II region; other site 315730005130 G3 box; other site 315730005131 G4 box; other site 315730005132 G5 box; other site 315730005133 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 315730005134 G1 box; other site 315730005135 GTP/Mg2+ binding site [chemical binding]; other site 315730005136 Switch I region; other site 315730005137 G2 box; other site 315730005138 G3 box; other site 315730005139 Switch II region; other site 315730005140 G4 box; other site 315730005141 G5 box; other site 315730005142 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 315730005143 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315730005144 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 315730005145 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 315730005146 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 315730005147 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 315730005148 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 315730005149 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730005150 IHF dimer interface [polypeptide binding]; other site 315730005151 IHF - DNA interface [nucleotide binding]; other site 315730005152 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 315730005153 homodecamer interface [polypeptide binding]; other site 315730005154 GTP cyclohydrolase I; Provisional; Region: PLN03044 315730005155 active site 315730005156 putative catalytic site residues [active] 315730005157 zinc binding site [ion binding]; other site 315730005158 GTP-CH-I/GFRP interaction surface; other site 315730005159 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 315730005160 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 315730005161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730005162 S-adenosylmethionine binding site [chemical binding]; other site 315730005163 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315730005164 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315730005165 substrate binding pocket [chemical binding]; other site 315730005166 chain length determination region; other site 315730005167 substrate-Mg2+ binding site; other site 315730005168 catalytic residues [active] 315730005169 aspartate-rich region 1; other site 315730005170 active site lid residues [active] 315730005171 aspartate-rich region 2; other site 315730005172 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 315730005173 active site 315730005174 multimer interface [polypeptide binding]; other site 315730005175 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 315730005176 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315730005177 Tetramer interface [polypeptide binding]; other site 315730005178 active site 315730005179 FMN-binding site [chemical binding]; other site 315730005180 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 315730005181 active site 315730005182 dimer interface [polypeptide binding]; other site 315730005183 metal binding site [ion binding]; metal-binding site 315730005184 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 315730005185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005187 homodimer interface [polypeptide binding]; other site 315730005188 catalytic residue [active] 315730005189 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 315730005190 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315730005191 hinge; other site 315730005192 active site 315730005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730005194 binding surface 315730005195 TPR motif; other site 315730005196 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 315730005197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730005198 binding surface 315730005199 TPR motif; other site 315730005200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730005201 TPR repeat; Region: TPR_11; pfam13414 315730005202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730005203 binding surface 315730005204 TPR motif; other site 315730005205 hypothetical protein; Provisional; Region: PRK03636 315730005206 UPF0302 domain; Region: UPF0302; pfam08864 315730005207 IDEAL domain; Region: IDEAL; pfam08858 315730005208 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 315730005209 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315730005210 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 315730005211 iron-sulfur cluster [ion binding]; other site 315730005212 [2Fe-2S] cluster binding site [ion binding]; other site 315730005213 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 315730005214 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 315730005215 interchain domain interface [polypeptide binding]; other site 315730005216 intrachain domain interface; other site 315730005217 heme bH binding site [chemical binding]; other site 315730005218 Qi binding site; other site 315730005219 heme bL binding site [chemical binding]; other site 315730005220 Qo binding site; other site 315730005221 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 315730005222 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 315730005223 interchain domain interface [polypeptide binding]; other site 315730005224 intrachain domain interface; other site 315730005225 Qi binding site; other site 315730005226 Qo binding site; other site 315730005227 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315730005228 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315730005229 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 315730005230 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 315730005231 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 315730005232 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 315730005233 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 315730005234 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 315730005235 active site 315730005236 Fe-S cluster binding site [ion binding]; other site 315730005237 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730005238 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730005239 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730005240 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730005241 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 315730005242 homodimer interface [polypeptide binding]; other site 315730005243 metal binding site [ion binding]; metal-binding site 315730005244 dihydrodipicolinate reductase; Provisional; Region: PRK00048 315730005245 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 315730005246 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 315730005247 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 315730005248 active site 315730005249 dimer interfaces [polypeptide binding]; other site 315730005250 catalytic residues [active] 315730005251 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 315730005252 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 315730005253 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 315730005254 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 315730005255 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 315730005256 active site 315730005257 NTP binding site [chemical binding]; other site 315730005258 metal binding triad [ion binding]; metal-binding site 315730005259 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 315730005260 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 315730005261 Biotin operon repressor [Transcription]; Region: BirA; COG1654 315730005262 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 315730005263 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 315730005264 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 315730005265 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 315730005266 oligomerization interface [polypeptide binding]; other site 315730005267 active site 315730005268 metal binding site [ion binding]; metal-binding site 315730005269 pantoate--beta-alanine ligase; Region: panC; TIGR00018 315730005270 Pantoate-beta-alanine ligase; Region: PanC; cd00560 315730005271 active site 315730005272 ATP-binding site [chemical binding]; other site 315730005273 pantoate-binding site; other site 315730005274 HXXH motif; other site 315730005275 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 315730005276 tetramerization interface [polypeptide binding]; other site 315730005277 active site 315730005278 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 315730005279 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730005280 active site 315730005281 catalytic site [active] 315730005282 substrate binding site [chemical binding]; other site 315730005283 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 315730005284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730005285 nucleotide binding region [chemical binding]; other site 315730005286 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 315730005287 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 315730005288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 315730005289 aspartate aminotransferase; Provisional; Region: PRK05764 315730005290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730005291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005292 homodimer interface [polypeptide binding]; other site 315730005293 catalytic residue [active] 315730005294 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 315730005295 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 315730005296 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315730005297 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 315730005298 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730005299 minor groove reading motif; other site 315730005300 helix-hairpin-helix signature motif; other site 315730005301 substrate binding pocket [chemical binding]; other site 315730005302 active site 315730005303 Transglycosylase; Region: Transgly; pfam00912 315730005304 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730005305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730005306 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730005307 Interdomain contacts; other site 315730005308 Cytokine receptor motif; other site 315730005309 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 315730005310 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315730005311 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 315730005312 YppF-like protein; Region: YppF; pfam14178 315730005313 YppG-like protein; Region: YppG; pfam14179 315730005314 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 315730005315 hypothetical protein; Provisional; Region: PRK13660 315730005316 cell division protein GpsB; Provisional; Region: PRK14127 315730005317 DivIVA domain; Region: DivI1A_domain; TIGR03544 315730005318 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 315730005319 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 315730005320 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 315730005321 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 315730005322 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 315730005323 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 315730005324 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 315730005325 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 315730005326 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 315730005327 active site 315730005328 Zn binding site [ion binding]; other site 315730005329 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730005330 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730005331 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730005332 active site 315730005333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730005334 active site 315730005335 xanthine permease; Region: pbuX; TIGR03173 315730005336 Predicted membrane protein [Function unknown]; Region: COG2311 315730005337 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730005338 Protein of unknown function (DUF418); Region: DUF418; pfam04235 315730005339 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315730005340 Dynamin family; Region: Dynamin_N; pfam00350 315730005341 G1 box; other site 315730005342 GTP/Mg2+ binding site [chemical binding]; other site 315730005343 G2 box; other site 315730005344 Switch I region; other site 315730005345 G3 box; other site 315730005346 Switch II region; other site 315730005347 G4 box; other site 315730005348 G5 box; other site 315730005349 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 315730005350 Dynamin family; Region: Dynamin_N; pfam00350 315730005351 G1 box; other site 315730005352 GTP/Mg2+ binding site [chemical binding]; other site 315730005353 G2 box; other site 315730005354 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315730005355 G3 box; other site 315730005356 Switch II region; other site 315730005357 GTP/Mg2+ binding site [chemical binding]; other site 315730005358 G4 box; other site 315730005359 G5 box; other site 315730005360 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 315730005361 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730005362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005363 Coenzyme A binding pocket [chemical binding]; other site 315730005364 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 315730005365 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 315730005366 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 315730005367 active site residue [active] 315730005368 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 315730005369 active site residue [active] 315730005370 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 315730005371 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315730005372 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315730005373 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 315730005374 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730005375 5'-3' exonuclease; Region: 53EXOc; smart00475 315730005376 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315730005377 active site 315730005378 metal binding site 1 [ion binding]; metal-binding site 315730005379 putative 5' ssDNA interaction site; other site 315730005380 metal binding site 3; metal-binding site 315730005381 metal binding site 2 [ion binding]; metal-binding site 315730005382 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315730005383 putative DNA binding site [nucleotide binding]; other site 315730005384 putative metal binding site [ion binding]; other site 315730005385 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315730005386 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730005387 Isochorismatase family; Region: Isochorismatase; pfam00857 315730005388 catalytic triad [active] 315730005389 conserved cis-peptide bond; other site 315730005390 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730005391 EamA-like transporter family; Region: EamA; pfam00892 315730005392 EamA-like transporter family; Region: EamA; pfam00892 315730005393 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315730005394 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730005395 active site 315730005396 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 315730005397 active site 315730005398 catalytic residues [active] 315730005399 QueT transporter; Region: QueT; pfam06177 315730005400 hypothetical protein; Validated; Region: PRK07708 315730005401 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315730005402 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730005403 active site 315730005404 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 315730005405 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 315730005406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730005407 DNA-binding site [nucleotide binding]; DNA binding site 315730005408 RNA-binding motif; other site 315730005409 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 315730005410 LysE type translocator; Region: LysE; pfam01810 315730005411 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 315730005412 Protein of unknown function, DUF485; Region: DUF485; pfam04341 315730005413 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730005414 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 315730005415 Na binding site [ion binding]; other site 315730005416 aminotransferase; Validated; Region: PRK07678 315730005417 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730005418 inhibitor-cofactor binding pocket; inhibition site 315730005419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005420 catalytic residue [active] 315730005421 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315730005422 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315730005423 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730005424 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315730005425 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730005426 DNA binding residues [nucleotide binding] 315730005427 drug binding residues [chemical binding]; other site 315730005428 dimer interface [polypeptide binding]; other site 315730005429 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 315730005430 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 315730005431 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 315730005432 Predicted membrane protein [Function unknown]; Region: COG2323 315730005433 Uncharacterized conserved protein [Function unknown]; Region: COG1434 315730005434 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730005435 putative active site [active] 315730005436 Tic20-like protein; Region: Tic20; pfam09685 315730005437 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 315730005438 dimer interface [polypeptide binding]; other site 315730005439 FMN binding site [chemical binding]; other site 315730005440 NADPH bind site [chemical binding]; other site 315730005441 RNA polymerase factor sigma-70; Validated; Region: PRK06811 315730005442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005444 DNA binding residues [nucleotide binding] 315730005445 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005447 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005448 putative substrate translocation pore; other site 315730005449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730005450 dimerization interface [polypeptide binding]; other site 315730005451 putative DNA binding site [nucleotide binding]; other site 315730005452 putative Zn2+ binding site [ion binding]; other site 315730005453 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005455 putative substrate translocation pore; other site 315730005456 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730005457 active site 315730005458 metal binding site [ion binding]; metal-binding site 315730005459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005460 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730005461 bacterial Hfq-like; Region: Hfq; cd01716 315730005462 hexamer interface [polypeptide binding]; other site 315730005463 Sm1 motif; other site 315730005464 RNA binding site [nucleotide binding]; other site 315730005465 Sm2 motif; other site 315730005466 HD domain; Region: HD_3; pfam13023 315730005467 flagellar motor protein MotP; Reviewed; Region: PRK06743 315730005468 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315730005469 flagellar motor protein MotS; Reviewed; Region: PRK06742 315730005470 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315730005471 ligand binding site [chemical binding]; other site 315730005472 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005474 active site 315730005475 phosphorylation site [posttranslational modification] 315730005476 intermolecular recognition site; other site 315730005477 dimerization interface [polypeptide binding]; other site 315730005478 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 315730005479 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 315730005480 putative binding surface; other site 315730005481 active site 315730005482 P2 response regulator binding domain; Region: P2; pfam07194 315730005483 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 315730005484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005485 ATP binding site [chemical binding]; other site 315730005486 Mg2+ binding site [ion binding]; other site 315730005487 G-X-G motif; other site 315730005488 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 315730005489 flagellar motor switch protein; Reviewed; Region: PRK06782 315730005490 CheC-like family; Region: CheC; pfam04509 315730005491 CheC-like family; Region: CheC; pfam04509 315730005492 CheC-like family; Region: CheC; pfam04509 315730005493 CheC-like family; Region: CheC; pfam04509 315730005494 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315730005495 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315730005496 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315730005497 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 315730005498 Protein of unknown function (DUF327); Region: DUF327; pfam03885 315730005499 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 315730005500 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315730005501 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 315730005502 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005503 flagellar capping protein; Validated; Region: fliD; PRK06798 315730005504 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 315730005505 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 315730005506 Flagellar protein FliS; Region: FliS; cl00654 315730005507 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 315730005508 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 315730005509 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 315730005510 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 315730005511 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315730005512 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 315730005513 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 315730005514 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 315730005515 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 315730005516 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 315730005517 FliG C-terminal domain; Region: FliG_C; pfam01706 315730005518 flagellar assembly protein H; Validated; Region: fliH; PRK06800 315730005519 Flagellar assembly protein FliH; Region: FliH; pfam02108 315730005520 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 315730005521 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 315730005522 Walker A motif; other site 315730005523 ATP binding site [chemical binding]; other site 315730005524 Walker B motif; other site 315730005525 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 315730005526 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 315730005527 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 315730005528 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 315730005529 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 315730005530 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 315730005531 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 315730005532 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315730005533 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 315730005534 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 315730005535 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005537 active site 315730005538 phosphorylation site [posttranslational modification] 315730005539 intermolecular recognition site; other site 315730005540 dimerization interface [polypeptide binding]; other site 315730005541 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 315730005542 S-layer homology domain; Region: SLH; pfam00395 315730005543 S-layer homology domain; Region: SLH; pfam00395 315730005544 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730005545 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730005546 active site 315730005547 metal binding site [ion binding]; metal-binding site 315730005548 PAS fold; Region: PAS_4; pfam08448 315730005549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730005550 putative active site [active] 315730005551 heme pocket [chemical binding]; other site 315730005552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730005553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730005554 metal binding site [ion binding]; metal-binding site 315730005555 active site 315730005556 I-site; other site 315730005557 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730005558 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 315730005559 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005560 flagellin; Provisional; Region: PRK12807 315730005561 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005562 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005563 flagellin; Provisional; Region: PRK12807 315730005564 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005565 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005566 flagellin; Provisional; Region: PRK12807 315730005567 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005568 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005569 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 315730005570 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 315730005571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315730005572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730005573 catalytic residue [active] 315730005574 flagellar motor switch protein; Validated; Region: PRK06789 315730005575 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 315730005576 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 315730005577 flagellar motor switch protein; Validated; Region: PRK06788 315730005578 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 315730005579 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 315730005580 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 315730005581 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 315730005582 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 315730005583 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 315730005584 FHIPEP family; Region: FHIPEP; pfam00771 315730005585 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 315730005586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315730005587 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 315730005588 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 315730005589 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 315730005590 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 315730005591 active site 315730005592 non-prolyl cis peptide bond; other site 315730005593 Predicted transcriptional regulators [Transcription]; Region: COG1378 315730005594 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 315730005595 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730005596 C-terminal domain interface [polypeptide binding]; other site 315730005597 sugar binding site [chemical binding]; other site 315730005598 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 315730005599 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 315730005600 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 315730005601 VanZ like family; Region: VanZ; pfam04892 315730005602 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 315730005603 Small acid-soluble spore protein H family; Region: SspH; pfam08141 315730005604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730005605 non-specific DNA binding site [nucleotide binding]; other site 315730005606 salt bridge; other site 315730005607 sequence-specific DNA binding site [nucleotide binding]; other site 315730005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005609 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005610 putative substrate translocation pore; other site 315730005611 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 315730005612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730005613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730005614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005615 dimerization interface [polypeptide binding]; other site 315730005616 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 315730005617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730005618 Walker A/P-loop; other site 315730005619 ATP binding site [chemical binding]; other site 315730005620 Q-loop/lid; other site 315730005621 ABC transporter signature motif; other site 315730005622 Walker B; other site 315730005623 D-loop; other site 315730005624 H-loop/switch region; other site 315730005625 TOBE domain; Region: TOBE_2; pfam08402 315730005626 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 315730005627 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 315730005628 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 315730005629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730005630 dimer interface [polypeptide binding]; other site 315730005631 conserved gate region; other site 315730005632 putative PBP binding loops; other site 315730005633 ABC-ATPase subunit interface; other site 315730005634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730005635 dimer interface [polypeptide binding]; other site 315730005636 conserved gate region; other site 315730005637 putative PBP binding loops; other site 315730005638 ABC-ATPase subunit interface; other site 315730005639 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 315730005640 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 315730005641 Beta-Casp domain; Region: Beta-Casp; smart01027 315730005642 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730005643 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315730005644 Cupin; Region: Cupin_1; smart00835 315730005645 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315730005646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730005647 catalytic core [active] 315730005648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730005649 hypothetical protein; Provisional; Region: PRK09272 315730005650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730005651 MarR family; Region: MarR_2; pfam12802 315730005652 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730005653 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730005654 active site 315730005655 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730005656 dimer interface [polypeptide binding]; other site 315730005657 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730005658 Ligand Binding Site [chemical binding]; other site 315730005659 Molecular Tunnel; other site 315730005660 RNA polymerase factor sigma-70; Validated; Region: PRK06811 315730005661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005663 DNA binding residues [nucleotide binding] 315730005664 VPS10 domain; Region: VPS10; smart00602 315730005665 VPS10 domain; Region: VPS10; smart00602 315730005666 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 315730005667 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730005668 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 315730005669 Transcriptional regulators [Transcription]; Region: GntR; COG1802 315730005670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730005671 DNA-binding site [nucleotide binding]; DNA binding site 315730005672 FCD domain; Region: FCD; pfam07729 315730005673 EamA-like transporter family; Region: EamA; pfam00892 315730005674 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730005675 EamA-like transporter family; Region: EamA; pfam00892 315730005676 Methyltransferase domain; Region: Methyltransf_24; pfam13578 315730005677 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730005678 fumarate hydratase; Reviewed; Region: fumC; PRK00485 315730005679 Class II fumarases; Region: Fumarase_classII; cd01362 315730005680 active site 315730005681 tetramer interface [polypeptide binding]; other site 315730005682 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730005683 FAD binding domain; Region: FAD_binding_4; pfam01565 315730005684 Berberine and berberine like; Region: BBE; pfam08031 315730005685 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730005686 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 315730005687 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730005688 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 315730005689 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 315730005690 active site pocket [active] 315730005691 oxyanion hole [active] 315730005692 catalytic triad [active] 315730005693 active site nucleophile [active] 315730005694 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 315730005695 Penicillinase repressor; Region: Pencillinase_R; pfam03965 315730005696 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 315730005697 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 315730005698 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 315730005699 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730005700 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315730005701 catalytic residues [active] 315730005702 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 315730005703 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730005704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730005705 non-specific DNA binding site [nucleotide binding]; other site 315730005706 salt bridge; other site 315730005707 sequence-specific DNA binding site [nucleotide binding]; other site 315730005708 Cupin domain; Region: Cupin_2; pfam07883 315730005709 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 315730005710 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 315730005711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730005712 catalytic residue [active] 315730005713 Protein of unknown function (DUF445); Region: DUF445; pfam04286 315730005714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005715 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 315730005716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005717 DNA binding residues [nucleotide binding] 315730005718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730005719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005720 active site 315730005721 phosphorylation site [posttranslational modification] 315730005722 intermolecular recognition site; other site 315730005723 dimerization interface [polypeptide binding]; other site 315730005724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730005725 DNA binding residues [nucleotide binding] 315730005726 dimerization interface [polypeptide binding]; other site 315730005727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730005728 Histidine kinase; Region: HisKA_3; pfam07730 315730005729 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730005730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730005731 Walker A/P-loop; other site 315730005732 ATP binding site [chemical binding]; other site 315730005733 Q-loop/lid; other site 315730005734 ABC transporter signature motif; other site 315730005735 Walker B; other site 315730005736 D-loop; other site 315730005737 H-loop/switch region; other site 315730005738 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315730005739 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315730005740 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 315730005741 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315730005742 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 315730005743 PGAP1-like protein; Region: PGAP1; pfam07819 315730005744 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730005745 putative active site [active] 315730005746 catalytic site [active] 315730005747 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730005748 PLD-like domain; Region: PLDc_2; pfam13091 315730005749 putative active site [active] 315730005750 catalytic site [active] 315730005751 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315730005752 putative nucleotide binding site [chemical binding]; other site 315730005753 uridine monophosphate binding site [chemical binding]; other site 315730005754 homohexameric interface [polypeptide binding]; other site 315730005755 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730005756 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730005757 aspartate ammonia-lyase; Provisional; Region: PRK14515 315730005758 Aspartase; Region: Aspartase; cd01357 315730005759 active sites [active] 315730005760 tetramer interface [polypeptide binding]; other site 315730005761 malate dehydrogenase; Provisional; Region: PRK13529 315730005762 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730005763 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315730005764 NAD(P) binding site [chemical binding]; other site 315730005765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730005766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005767 ATP binding site [chemical binding]; other site 315730005768 Mg2+ binding site [ion binding]; other site 315730005769 G-X-G motif; other site 315730005770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005771 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005772 active site 315730005773 phosphorylation site [posttranslational modification] 315730005774 intermolecular recognition site; other site 315730005775 dimerization interface [polypeptide binding]; other site 315730005776 YcbB domain; Region: YcbB; pfam08664 315730005777 SWIM zinc finger; Region: SWIM; pfam04434 315730005778 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 315730005779 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315730005780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730005781 ATP binding site [chemical binding]; other site 315730005782 putative Mg++ binding site [ion binding]; other site 315730005783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730005784 nucleotide binding region [chemical binding]; other site 315730005785 ATP-binding site [chemical binding]; other site 315730005786 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 315730005787 dimer interface [polypeptide binding]; other site 315730005788 active site 315730005789 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 315730005790 putative dimer interface [polypeptide binding]; other site 315730005791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005792 aspartate kinase; Reviewed; Region: PRK06635 315730005793 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 315730005794 putative nucleotide binding site [chemical binding]; other site 315730005795 putative catalytic residues [active] 315730005796 putative Mg ion binding site [ion binding]; other site 315730005797 putative aspartate binding site [chemical binding]; other site 315730005798 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 315730005799 putative allosteric regulatory site; other site 315730005800 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 315730005801 putative allosteric regulatory residue; other site 315730005802 DoxX-like family; Region: DoxX_3; pfam13781 315730005803 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 315730005804 YndJ-like protein; Region: YndJ; pfam14158 315730005805 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730005806 putative active site [active] 315730005807 nucleotide binding site [chemical binding]; other site 315730005808 nudix motif; other site 315730005809 putative metal binding site [ion binding]; other site 315730005810 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 315730005811 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 315730005812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730005814 putative substrate translocation pore; other site 315730005815 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 315730005816 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315730005817 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315730005818 HflX GTPase family; Region: HflX; cd01878 315730005819 G1 box; other site 315730005820 GTP/Mg2+ binding site [chemical binding]; other site 315730005821 Switch I region; other site 315730005822 G2 box; other site 315730005823 G3 box; other site 315730005824 Switch II region; other site 315730005825 G4 box; other site 315730005826 G5 box; other site 315730005827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730005829 putative substrate translocation pore; other site 315730005830 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730005831 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730005832 dimer interface [polypeptide binding]; other site 315730005833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005834 catalytic residue [active] 315730005835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730005837 Coenzyme A binding pocket [chemical binding]; other site 315730005838 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 315730005839 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730005840 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730005841 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 315730005842 Na2 binding site [ion binding]; other site 315730005843 putative substrate binding site 1 [chemical binding]; other site 315730005844 Na binding site 1 [ion binding]; other site 315730005845 putative substrate binding site 2 [chemical binding]; other site 315730005846 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730005847 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 315730005848 NodB motif; other site 315730005849 putative active site [active] 315730005850 putative catalytic site [active] 315730005851 putative Zn binding site [ion binding]; other site 315730005852 Fumarase C C-terminus; Region: FumaraseC_C; pfam10415 315730005853 Predicted membrane protein [Function unknown]; Region: COG2323 315730005854 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 315730005855 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005856 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005857 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005858 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005859 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005860 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005861 methionine sulfoxide reductase A; Provisional; Region: PRK14054 315730005862 short chain dehydrogenase; Provisional; Region: PRK12747 315730005863 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 315730005864 NADP binding site [chemical binding]; other site 315730005865 homodimer interface [polypeptide binding]; other site 315730005866 active site 315730005867 substrate binding site [chemical binding]; other site 315730005868 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315730005869 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730005870 homodimer interface [polypeptide binding]; other site 315730005871 substrate-cofactor binding pocket; other site 315730005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005873 catalytic residue [active] 315730005874 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 315730005875 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730005876 PYR/PP interface [polypeptide binding]; other site 315730005877 dimer interface [polypeptide binding]; other site 315730005878 TPP binding site [chemical binding]; other site 315730005879 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315730005880 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315730005881 TPP-binding site [chemical binding]; other site 315730005882 dimer interface [polypeptide binding]; other site 315730005883 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 315730005884 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315730005885 putative valine binding site [chemical binding]; other site 315730005886 dimer interface [polypeptide binding]; other site 315730005887 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315730005888 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 315730005889 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315730005890 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 315730005891 threonine dehydratase; Validated; Region: PRK08639 315730005892 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 315730005893 tetramer interface [polypeptide binding]; other site 315730005894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005895 catalytic residue [active] 315730005896 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 315730005897 putative Ile/Val binding site [chemical binding]; other site 315730005898 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315730005899 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315730005900 putative active site [active] 315730005901 putative metal binding site [ion binding]; other site 315730005902 Protein of unknown function (DUF554); Region: DUF554; pfam04474 315730005903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005904 Coenzyme A binding pocket [chemical binding]; other site 315730005905 drug efflux system protein MdtG; Provisional; Region: PRK09874 315730005906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005907 putative substrate translocation pore; other site 315730005908 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 315730005909 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 315730005910 putative active site [active] 315730005911 metal binding site [ion binding]; metal-binding site 315730005912 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315730005913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315730005914 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315730005915 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315730005916 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315730005917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730005918 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730005919 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 315730005920 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 315730005921 active site 315730005922 putative substrate binding pocket [chemical binding]; other site 315730005923 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730005924 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730005925 active site 315730005926 metal binding site [ion binding]; metal-binding site 315730005927 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 315730005928 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730005929 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730005930 peptide binding site [polypeptide binding]; other site 315730005931 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 315730005932 hypothetical protein; Provisional; Region: PRK06922 315730005933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730005934 S-adenosylmethionine binding site [chemical binding]; other site 315730005935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730005936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005937 Coenzyme A binding pocket [chemical binding]; other site 315730005938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730005939 manganese transport protein MntH; Reviewed; Region: PRK00701 315730005940 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 315730005941 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 315730005942 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 315730005943 active site residue [active] 315730005944 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 315730005945 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 315730005946 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 315730005947 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315730005948 Amino acid permease; Region: AA_permease_2; pfam13520 315730005949 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005950 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005951 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005952 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 315730005953 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730005954 active site 315730005955 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 315730005956 Uncharacterized conserved protein [Function unknown]; Region: COG2128 315730005957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730005958 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730005959 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 315730005960 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 315730005961 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 315730005962 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730005963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005964 DNA binding residues [nucleotide binding] 315730005965 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730005966 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 315730005967 intersubunit interface [polypeptide binding]; other site 315730005968 active site 315730005969 catalytic residue [active] 315730005970 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730005971 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730005972 Nucleoside recognition; Region: Gate; pfam07670 315730005973 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730005974 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315730005975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730005976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730005977 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 315730005978 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315730005979 active site 315730005980 catalytic motif [active] 315730005981 Zn binding site [ion binding]; other site 315730005982 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 315730005983 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 315730005984 hypothetical protein; Provisional; Region: PRK01631 315730005985 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 315730005986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730005987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730005988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730005989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005990 dimerization interface [polypeptide binding]; other site 315730005991 VPS10 domain; Region: VPS10; smart00602 315730005992 proline aminopeptidase P II; Provisional; Region: PRK10879 315730005993 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 315730005994 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 315730005995 active site 315730005996 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 315730005997 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 315730005998 Multicopper oxidase; Region: Cu-oxidase; pfam00394 315730005999 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 315730006000 DNA topoisomerase III; Provisional; Region: PRK07726 315730006001 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730006002 active site 315730006003 putative interdomain interaction site [polypeptide binding]; other site 315730006004 putative metal-binding site [ion binding]; other site 315730006005 putative nucleotide binding site [chemical binding]; other site 315730006006 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730006007 domain I; other site 315730006008 DNA binding groove [nucleotide binding] 315730006009 phosphate binding site [ion binding]; other site 315730006010 domain II; other site 315730006011 domain III; other site 315730006012 nucleotide binding site [chemical binding]; other site 315730006013 catalytic site [active] 315730006014 domain IV; other site 315730006015 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730006016 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 315730006017 Predicted membrane protein [Function unknown]; Region: COG2364 315730006018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730006019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730006020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730006021 dimerization interface [polypeptide binding]; other site 315730006022 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 315730006023 DNA binding site [nucleotide binding] 315730006024 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 315730006025 Sodium Bile acid symporter family; Region: SBF; cl17470 315730006026 azoreductase; Provisional; Region: PRK13555 315730006027 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315730006028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730006029 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 315730006030 dimer interface [polypeptide binding]; other site 315730006031 substrate binding site [chemical binding]; other site 315730006032 metal binding site [ion binding]; metal-binding site 315730006033 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 315730006034 Amidinotransferase; Region: Amidinotransf; pfam02274 315730006035 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 315730006036 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 315730006037 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730006038 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730006039 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 315730006040 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315730006041 putative di-iron ligands [ion binding]; other site 315730006042 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 315730006043 Thioesterase domain; Region: Thioesterase; pfam00975 315730006044 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006046 acyl-activating enzyme (AAE) consensus motif; other site 315730006047 AMP binding site [chemical binding]; other site 315730006048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006049 Condensation domain; Region: Condensation; pfam00668 315730006050 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730006052 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006053 acyl-activating enzyme (AAE) consensus motif; other site 315730006054 AMP binding site [chemical binding]; other site 315730006055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006056 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315730006057 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 315730006058 active site 315730006059 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315730006060 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 315730006061 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006062 thioester reductase domain; Region: Thioester-redct; TIGR01746 315730006063 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 315730006064 putative NAD(P) binding site [chemical binding]; other site 315730006065 active site 315730006066 putative substrate binding site [chemical binding]; other site 315730006067 Condensation domain; Region: Condensation; pfam00668 315730006068 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006070 acyl-activating enzyme (AAE) consensus motif; other site 315730006071 AMP binding site [chemical binding]; other site 315730006072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006073 Condensation domain; Region: Condensation; pfam00668 315730006074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006075 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730006076 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730006077 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730006078 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 315730006079 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 315730006080 Walker A/P-loop; other site 315730006081 ATP binding site [chemical binding]; other site 315730006082 Q-loop/lid; other site 315730006083 ABC transporter signature motif; other site 315730006084 Walker B; other site 315730006085 D-loop; other site 315730006086 H-loop/switch region; other site 315730006087 Condensation domain; Region: Condensation; pfam00668 315730006088 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006089 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006090 acyl-activating enzyme (AAE) consensus motif; other site 315730006091 AMP binding site [chemical binding]; other site 315730006092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006093 Condensation domain; Region: Condensation; pfam00668 315730006094 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730006095 Condensation domain; Region: Condensation; pfam00668 315730006096 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006097 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006098 acyl-activating enzyme (AAE) consensus motif; other site 315730006099 AMP binding site [chemical binding]; other site 315730006100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006101 Condensation domain; Region: Condensation; pfam00668 315730006102 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006103 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730006104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730006105 acyl-activating enzyme (AAE) consensus motif; other site 315730006106 AMP binding site [chemical binding]; other site 315730006107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730006108 Condensation domain; Region: Condensation; pfam00668 315730006109 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730006110 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730006111 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 315730006112 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 315730006113 YtkA-like; Region: YtkA; pfam13115 315730006114 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 315730006115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730006116 EamA-like transporter family; Region: EamA; pfam00892 315730006117 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730006118 EamA-like transporter family; Region: EamA; pfam00892 315730006119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730006120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730006121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730006122 dimerization interface [polypeptide binding]; other site 315730006123 Rrf2 family protein; Region: rrf2_super; TIGR00738 315730006124 Transcriptional regulator; Region: Rrf2; pfam02082 315730006125 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315730006126 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315730006127 catalytic residues [active] 315730006128 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 315730006129 dimer interface [polypeptide binding]; other site 315730006130 FMN binding site [chemical binding]; other site 315730006131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730006133 Coenzyme A binding pocket [chemical binding]; other site 315730006134 amidase; Provisional; Region: PRK06707 315730006135 Amidase; Region: Amidase; cl11426 315730006136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730006137 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730006138 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730006139 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730006140 NAD binding site [chemical binding]; other site 315730006141 dimer interface [polypeptide binding]; other site 315730006142 substrate binding site [chemical binding]; other site 315730006143 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 315730006144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730006145 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315730006146 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 315730006147 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 315730006148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 315730006149 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 315730006150 putative ligand binding site [chemical binding]; other site 315730006151 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 315730006152 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 315730006153 Walker A/P-loop; other site 315730006154 ATP binding site [chemical binding]; other site 315730006155 Q-loop/lid; other site 315730006156 ABC transporter signature motif; other site 315730006157 Walker B; other site 315730006158 D-loop; other site 315730006159 H-loop/switch region; other site 315730006160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 315730006161 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 315730006162 Walker A/P-loop; other site 315730006163 ATP binding site [chemical binding]; other site 315730006164 Q-loop/lid; other site 315730006165 ABC transporter signature motif; other site 315730006166 Walker B; other site 315730006167 D-loop; other site 315730006168 H-loop/switch region; other site 315730006169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730006170 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 315730006171 TM-ABC transporter signature motif; other site 315730006172 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 315730006173 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 315730006174 TM-ABC transporter signature motif; other site 315730006175 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730006176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730006177 putative Zn2+ binding site [ion binding]; other site 315730006178 putative DNA binding site [nucleotide binding]; other site 315730006179 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730006180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730006181 Zn binding site [ion binding]; other site 315730006182 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730006183 Zn binding site [ion binding]; other site 315730006184 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 315730006185 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315730006186 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 315730006187 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 315730006188 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 315730006189 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315730006190 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315730006191 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 315730006192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730006193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730006194 Walker A/P-loop; other site 315730006195 ATP binding site [chemical binding]; other site 315730006196 Q-loop/lid; other site 315730006197 ABC transporter signature motif; other site 315730006198 Walker B; other site 315730006199 D-loop; other site 315730006200 H-loop/switch region; other site 315730006201 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 315730006202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730006203 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 315730006204 Walker A/P-loop; other site 315730006205 ATP binding site [chemical binding]; other site 315730006206 Q-loop/lid; other site 315730006207 ABC transporter signature motif; other site 315730006208 Walker B; other site 315730006209 D-loop; other site 315730006210 H-loop/switch region; other site 315730006211 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 315730006212 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315730006213 putative dimer interface [polypeptide binding]; other site 315730006214 catalytic triad [active] 315730006215 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730006216 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730006217 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 315730006218 dimer interface [polypeptide binding]; other site 315730006219 FMN binding site [chemical binding]; other site 315730006220 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730006221 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730006222 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730006223 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315730006224 NlpC/P60 family; Region: NLPC_P60; pfam00877 315730006225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730006226 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730006227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730006228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730006229 Walker A/P-loop; other site 315730006230 ATP binding site [chemical binding]; other site 315730006231 Q-loop/lid; other site 315730006232 ABC transporter signature motif; other site 315730006233 Walker B; other site 315730006234 D-loop; other site 315730006235 H-loop/switch region; other site 315730006236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730006238 active site 315730006239 phosphorylation site [posttranslational modification] 315730006240 intermolecular recognition site; other site 315730006241 dimerization interface [polypeptide binding]; other site 315730006242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730006243 DNA binding site [nucleotide binding] 315730006244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730006245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730006246 dimerization interface [polypeptide binding]; other site 315730006247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730006248 dimer interface [polypeptide binding]; other site 315730006249 phosphorylation site [posttranslational modification] 315730006250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730006251 ATP binding site [chemical binding]; other site 315730006252 Mg2+ binding site [ion binding]; other site 315730006253 G-X-G motif; other site 315730006254 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 315730006255 classical (c) SDRs; Region: SDR_c; cd05233 315730006256 NAD(P) binding site [chemical binding]; other site 315730006257 active site 315730006258 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315730006259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006260 S-adenosylmethionine binding site [chemical binding]; other site 315730006261 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 315730006262 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730006263 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 315730006264 NodB motif; other site 315730006265 active site 315730006266 catalytic site [active] 315730006267 metal binding site [ion binding]; metal-binding site 315730006268 SdpI/YhfL protein family; Region: SdpI; pfam13630 315730006269 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730006270 nudix motif; other site 315730006271 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 315730006272 homoserine dehydrogenase; Provisional; Region: PRK06349 315730006273 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 315730006274 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730006275 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315730006276 threonine synthase; Reviewed; Region: PRK06721 315730006277 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315730006278 homodimer interface [polypeptide binding]; other site 315730006279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006280 catalytic residue [active] 315730006281 homoserine kinase; Provisional; Region: PRK01212 315730006282 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315730006283 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315730006284 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 315730006285 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730006286 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730006287 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730006288 NodB motif; other site 315730006289 active site 315730006290 catalytic site [active] 315730006291 Zn binding site [ion binding]; other site 315730006292 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730006293 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 315730006294 MgtC family; Region: MgtC; pfam02308 315730006295 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730006296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006297 Coenzyme A binding pocket [chemical binding]; other site 315730006298 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315730006299 IucA / IucC family; Region: IucA_IucC; pfam04183 315730006300 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315730006301 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315730006302 IucA / IucC family; Region: IucA_IucC; pfam04183 315730006303 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315730006304 acyl-CoA synthetase; Validated; Region: PRK08308 315730006305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730006306 acyl-activating enzyme (AAE) consensus motif; other site 315730006307 AMP binding site [chemical binding]; other site 315730006308 active site 315730006309 CoA binding site [chemical binding]; other site 315730006310 acyl carrier protein; Provisional; Region: PRK07639 315730006311 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 315730006312 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 315730006313 Metal-binding active site; metal-binding site 315730006314 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730006315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730006317 putative substrate translocation pore; other site 315730006318 Lysine efflux permease [General function prediction only]; Region: COG1279 315730006319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730006320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730006321 DNA-binding site [nucleotide binding]; DNA binding site 315730006322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730006323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006324 homodimer interface [polypeptide binding]; other site 315730006325 catalytic residue [active] 315730006326 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 315730006327 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315730006328 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315730006329 active site 315730006330 nucleophile elbow; other site 315730006331 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 315730006332 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 315730006333 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 315730006334 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 315730006335 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730006336 nudix motif; other site 315730006337 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 315730006338 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 315730006339 homodimer interface [polypeptide binding]; other site 315730006340 NAD binding pocket [chemical binding]; other site 315730006341 ATP binding pocket [chemical binding]; other site 315730006342 Mg binding site [ion binding]; other site 315730006343 active-site loop [active] 315730006344 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730006345 FtsX-like permease family; Region: FtsX; pfam02687 315730006346 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315730006347 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 315730006348 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315730006349 active site 315730006350 catalytic residues [active] 315730006351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730006352 dimerization interface [polypeptide binding]; other site 315730006353 putative DNA binding site [nucleotide binding]; other site 315730006354 putative Zn2+ binding site [ion binding]; other site 315730006355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730006356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730006357 active site 315730006358 catalytic tetrad [active] 315730006359 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 315730006360 Protein of unknown function (DUF664); Region: DUF664; pfam04978 315730006361 DinB superfamily; Region: DinB_2; pfam12867 315730006362 GTPase RsgA; Reviewed; Region: PRK01889 315730006363 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730006364 RNA binding site [nucleotide binding]; other site 315730006365 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315730006366 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315730006367 GTP/Mg2+ binding site [chemical binding]; other site 315730006368 G4 box; other site 315730006369 G5 box; other site 315730006370 G1 box; other site 315730006371 Switch I region; other site 315730006372 G2 box; other site 315730006373 G3 box; other site 315730006374 Switch II region; other site 315730006375 Tar ligand binding domain homologue; Region: TarH; pfam02203 315730006376 Cache domain; Region: Cache_1; pfam02743 315730006377 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730006378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730006379 dimerization interface [polypeptide binding]; other site 315730006380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730006381 dimer interface [polypeptide binding]; other site 315730006382 putative CheW interface [polypeptide binding]; other site 315730006383 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 315730006384 Uncharacterized membrane protein [Function unknown]; Region: COG3949 315730006385 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 315730006386 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315730006387 dimerization interface [polypeptide binding]; other site 315730006388 DPS ferroxidase diiron center [ion binding]; other site 315730006389 ion pore; other site 315730006390 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 315730006391 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730006392 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 315730006393 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315730006394 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 315730006395 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 315730006396 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 315730006397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730006398 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730006399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730006400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730006401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730006402 active site 315730006403 catalytic tetrad [active] 315730006404 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315730006405 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 315730006406 P-loop, Walker A motif; other site 315730006407 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 315730006408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006409 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730006410 Coenzyme A binding pocket [chemical binding]; other site 315730006411 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 315730006412 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 315730006413 metal binding site [ion binding]; metal-binding site 315730006414 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 315730006415 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730006416 NAD binding site [chemical binding]; other site 315730006417 active site 315730006418 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315730006419 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315730006420 active site 315730006421 FMN binding site [chemical binding]; other site 315730006422 substrate binding site [chemical binding]; other site 315730006423 homotetramer interface [polypeptide binding]; other site 315730006424 catalytic residue [active] 315730006425 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 315730006426 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315730006427 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315730006428 DNA binding site [nucleotide binding] 315730006429 active site 315730006430 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 315730006431 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730006432 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730006433 peptide binding site [polypeptide binding]; other site 315730006434 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 315730006435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730006436 active site 315730006437 metal binding site [ion binding]; metal-binding site 315730006438 short chain dehydrogenase; Provisional; Region: PRK08309 315730006439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730006440 catalytic core [active] 315730006441 CotH protein; Region: CotH; pfam08757 315730006442 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 315730006443 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 315730006444 nudix motif; other site 315730006445 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730006446 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730006447 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315730006448 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730006449 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 315730006450 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 315730006451 Cl binding site [ion binding]; other site 315730006452 oligomer interface [polypeptide binding]; other site 315730006453 Predicted permeases [General function prediction only]; Region: COG0701 315730006454 Predicted membrane protein [Function unknown]; Region: COG3689 315730006455 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315730006456 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 315730006457 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730006458 putative active site [active] 315730006459 catalytic site [active] 315730006460 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730006461 putative active site [active] 315730006462 catalytic site [active] 315730006463 Coat F domain; Region: Coat_F; pfam07875 315730006464 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315730006465 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730006466 NAD binding site [chemical binding]; other site 315730006467 substrate binding site [chemical binding]; other site 315730006468 putative active site [active] 315730006469 Protein of unknown function (DUF456); Region: DUF456; pfam04306 315730006470 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730006471 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730006472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730006473 Transporter associated domain; Region: CorC_HlyC; smart01091 315730006474 FOG: CBS domain [General function prediction only]; Region: COG0517 315730006475 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 315730006476 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 315730006477 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 315730006478 dimer interface [polypeptide binding]; other site 315730006479 putative tRNA-binding site [nucleotide binding]; other site 315730006480 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 315730006481 DinB superfamily; Region: DinB_2; pfam12867 315730006482 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315730006483 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315730006484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730006485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006486 Coenzyme A binding pocket [chemical binding]; other site 315730006487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730006488 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730006489 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315730006490 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730006491 nudix motif; other site 315730006492 amidase; Provisional; Region: PRK06828 315730006493 Amidase; Region: Amidase; cl11426 315730006494 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 315730006495 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 315730006496 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 315730006497 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315730006498 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315730006499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730006500 catalytic core [active] 315730006501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730006503 active site 315730006504 motif I; other site 315730006505 motif II; other site 315730006506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730006508 MarR family; Region: MarR; pfam01047 315730006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730006511 putative substrate translocation pore; other site 315730006512 DinB superfamily; Region: DinB_2; pfam12867 315730006513 DinB family; Region: DinB; cl17821 315730006514 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730006515 alanine racemase; Reviewed; Region: alr; PRK00053 315730006516 active site 315730006517 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730006518 dimer interface [polypeptide binding]; other site 315730006519 substrate binding site [chemical binding]; other site 315730006520 catalytic residues [active] 315730006521 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730006522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006523 S-adenosylmethionine binding site [chemical binding]; other site 315730006524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006525 Coenzyme A binding pocket [chemical binding]; other site 315730006526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006527 Coenzyme A binding pocket [chemical binding]; other site 315730006528 Phosphotransferase enzyme family; Region: APH; pfam01636 315730006529 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315730006530 active site 315730006531 ATP binding site [chemical binding]; other site 315730006532 substrate binding site [chemical binding]; other site 315730006533 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730006534 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730006535 active site 315730006536 TDP-binding site; other site 315730006537 acceptor substrate-binding pocket; other site 315730006538 homodimer interface [polypeptide binding]; other site 315730006539 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730006540 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730006541 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730006542 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730006543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730006544 DNA-binding site [nucleotide binding]; DNA binding site 315730006545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730006546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006547 homodimer interface [polypeptide binding]; other site 315730006548 catalytic residue [active] 315730006549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006550 Coenzyme A binding pocket [chemical binding]; other site 315730006551 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730006552 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315730006553 active site 315730006554 metal binding site [ion binding]; metal-binding site 315730006555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730006556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006557 Coenzyme A binding pocket [chemical binding]; other site 315730006558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730006559 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 315730006560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730006561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006562 Coenzyme A binding pocket [chemical binding]; other site 315730006563 Cupin domain; Region: Cupin_2; cl17218 315730006564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006565 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730006566 Coenzyme A binding pocket [chemical binding]; other site 315730006567 Predicted acetyltransferase [General function prediction only]; Region: COG3393 315730006568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730006569 Coenzyme A binding pocket [chemical binding]; other site 315730006570 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730006571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730006572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006573 S-adenosylmethionine binding site [chemical binding]; other site 315730006574 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 315730006575 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 315730006576 Potassium binding sites [ion binding]; other site 315730006577 Cesium cation binding sites [ion binding]; other site 315730006578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 315730006579 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730006580 ATP binding site [chemical binding]; other site 315730006581 putative Mg++ binding site [ion binding]; other site 315730006582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730006583 nucleotide binding region [chemical binding]; other site 315730006584 ATP-binding site [chemical binding]; other site 315730006585 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730006586 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 315730006587 NADP binding site [chemical binding]; other site 315730006588 dimer interface [polypeptide binding]; other site 315730006589 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730006590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730006591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730006592 DNA binding residues [nucleotide binding] 315730006593 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 315730006594 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 315730006595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730006596 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 315730006597 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 315730006598 catalytic residues [active] 315730006599 dimer interface [polypeptide binding]; other site 315730006600 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 315730006601 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 315730006602 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 315730006603 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315730006604 Protein of unknown function DUF58; Region: DUF58; pfam01882 315730006605 MoxR-like ATPases [General function prediction only]; Region: COG0714 315730006606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730006607 Walker A motif; other site 315730006608 ATP binding site [chemical binding]; other site 315730006609 Walker B motif; other site 315730006610 arginine finger; other site 315730006611 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 315730006612 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 315730006613 [4Fe-4S] binding site [ion binding]; other site 315730006614 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006615 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006616 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006617 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 315730006618 molybdopterin cofactor binding site; other site 315730006619 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 315730006620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 315730006621 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 315730006622 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 315730006623 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315730006624 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730006625 ligand binding site [chemical binding]; other site 315730006626 flexible hinge region; other site 315730006627 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 315730006628 putative switch regulator; other site 315730006629 non-specific DNA interactions [nucleotide binding]; other site 315730006630 DNA binding site [nucleotide binding] 315730006631 sequence specific DNA binding site [nucleotide binding]; other site 315730006632 putative cAMP binding site [chemical binding]; other site 315730006633 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 315730006634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730006635 FeS/SAM binding site; other site 315730006636 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315730006637 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 315730006638 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730006639 ATP binding site [chemical binding]; other site 315730006640 substrate interface [chemical binding]; other site 315730006641 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315730006642 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315730006643 dimer interface [polypeptide binding]; other site 315730006644 putative functional site; other site 315730006645 putative MPT binding site; other site 315730006646 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315730006647 MoaE homodimer interface [polypeptide binding]; other site 315730006648 MoaD interaction [polypeptide binding]; other site 315730006649 active site residues [active] 315730006650 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315730006651 MoaE interaction surface [polypeptide binding]; other site 315730006652 MoeB interaction surface [polypeptide binding]; other site 315730006653 thiocarboxylated glycine; other site 315730006654 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 315730006655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006656 putative substrate translocation pore; other site 315730006657 PspC domain; Region: PspC; pfam04024 315730006658 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 315730006659 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730006660 active site 315730006661 Predicted permeases [General function prediction only]; Region: COG0679 315730006662 precorrin-2 dehydrogenase; Validated; Region: PRK06719 315730006663 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 315730006664 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 315730006665 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315730006666 putative active site [active] 315730006667 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315730006668 putative active site [active] 315730006669 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 315730006670 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 315730006671 active site 315730006672 SAM binding site [chemical binding]; other site 315730006673 homodimer interface [polypeptide binding]; other site 315730006674 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 315730006675 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 315730006676 [2Fe-2S] cluster binding site [ion binding]; other site 315730006677 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 315730006678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730006679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730006680 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315730006681 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315730006682 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730006683 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 315730006684 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 315730006685 Hemerythrin-like domain; Region: Hr-like; cd12108 315730006686 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 315730006687 Lipase (class 2); Region: Lipase_2; pfam01674 315730006688 Putative serine esterase (DUF676); Region: DUF676; pfam05057 315730006689 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 315730006690 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 315730006691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730006692 Zn2+ binding site [ion binding]; other site 315730006693 Mg2+ binding site [ion binding]; other site 315730006694 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730006695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730006696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730006697 ABC transporter; Region: ABC_tran_2; pfam12848 315730006698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730006699 Bax inhibitor 1 like; Region: BaxI_1; cl17691 315730006700 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 315730006701 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315730006702 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730006703 dimer interface [polypeptide binding]; other site 315730006704 ssDNA binding site [nucleotide binding]; other site 315730006705 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730006706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730006707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730006708 hypothetical protein; Provisional; Region: PRK06753 315730006709 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 315730006710 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 315730006711 Virulence factor; Region: Virulence_fact; pfam13769 315730006712 HEAT repeats; Region: HEAT_2; pfam13646 315730006713 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 315730006714 Protein of unknown function, DUF393; Region: DUF393; pfam04134 315730006715 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315730006716 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 315730006717 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 315730006718 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 315730006719 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315730006720 active site 315730006721 HIGH motif; other site 315730006722 KMSK motif region; other site 315730006723 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 315730006724 tRNA binding surface [nucleotide binding]; other site 315730006725 anticodon binding site; other site 315730006726 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 315730006727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006729 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 315730006730 putative active site [active] 315730006731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006732 TPR motif; other site 315730006733 binding surface 315730006734 TPR repeat; Region: TPR_11; pfam13414 315730006735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006736 binding surface 315730006737 TPR motif; other site 315730006738 TPR repeat; Region: TPR_11; pfam13414 315730006739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006740 TPR motif; other site 315730006741 binding surface 315730006742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006743 binding surface 315730006744 TPR motif; other site 315730006745 TPR repeat; Region: TPR_11; pfam13414 315730006746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006747 binding surface 315730006748 TPR motif; other site 315730006749 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730006750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006751 binding surface 315730006752 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730006753 TPR motif; other site 315730006754 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 315730006755 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730006756 HIGH motif; other site 315730006757 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730006758 active site 315730006759 KMSKS motif; other site 315730006760 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 315730006761 tRNA binding surface [nucleotide binding]; other site 315730006762 anticodon binding site; other site 315730006763 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 315730006764 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730006765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730006766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730006767 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730006768 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730006769 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315730006770 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 315730006771 Zn binding site [ion binding]; other site 315730006772 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 315730006773 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730006774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730006775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730006776 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 315730006777 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 315730006778 Dimer interface [polypeptide binding]; other site 315730006779 anticodon binding site; other site 315730006780 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315730006781 homodimer interface [polypeptide binding]; other site 315730006782 motif 1; other site 315730006783 motif 2; other site 315730006784 active site 315730006785 motif 3; other site 315730006786 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315730006787 metal ion-dependent adhesion site (MIDAS); other site 315730006788 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730006789 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 315730006790 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730006791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730006792 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730006793 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730006794 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730006795 active site 315730006796 ATP binding site [chemical binding]; other site 315730006797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006798 binding surface 315730006799 TPR repeat; Region: TPR_11; pfam13414 315730006800 TPR motif; other site 315730006801 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730006802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006803 binding surface 315730006804 TPR motif; other site 315730006805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006806 binding surface 315730006807 TPR motif; other site 315730006808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730006809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006810 binding surface 315730006811 TPR motif; other site 315730006812 SseB protein; Region: SseB; cl06279 315730006813 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730006814 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730006815 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 315730006816 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730006817 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730006818 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730006819 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730006820 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730006821 catalytic residues [active] 315730006822 catalytic nucleophile [active] 315730006823 Recombinase; Region: Recombinase; pfam07508 315730006824 Transposase; Region: DEDD_Tnp_IS110; pfam01548 315730006825 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 315730006826 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730006827 Herpesvirus DNA helicase/primase complex associated protein; Region: Herpes_HEPA; cl17366 315730006828 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 315730006829 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 315730006830 Na2 binding site [ion binding]; other site 315730006831 putative substrate binding site 1 [chemical binding]; other site 315730006832 Na binding site 1 [ion binding]; other site 315730006833 putative substrate binding site 2 [chemical binding]; other site 315730006834 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730006835 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 315730006836 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 315730006837 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730006838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006839 motif II; other site 315730006840 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 315730006841 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315730006842 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315730006843 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 315730006844 putative active site [active] 315730006845 metal binding site [ion binding]; metal-binding site 315730006846 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 315730006847 aspartate racemase; Region: asp_race; TIGR00035 315730006848 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 315730006849 homodimer interaction site [polypeptide binding]; other site 315730006850 cofactor binding site; other site 315730006851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730006852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006853 Coenzyme A binding pocket [chemical binding]; other site 315730006854 hypothetical protein; Validated; Region: PRK06769 315730006855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006856 active site 315730006857 motif I; other site 315730006858 motif II; other site 315730006859 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730006860 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730006861 Walker A/P-loop; other site 315730006862 ATP binding site [chemical binding]; other site 315730006863 Q-loop/lid; other site 315730006864 ABC transporter signature motif; other site 315730006865 Walker B; other site 315730006866 D-loop; other site 315730006867 H-loop/switch region; other site 315730006868 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 315730006869 YpjP-like protein; Region: YpjP; pfam14005 315730006870 Phosphotransferase enzyme family; Region: APH; pfam01636 315730006871 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730006872 active site 315730006873 substrate binding site [chemical binding]; other site 315730006874 ATP binding site [chemical binding]; other site 315730006875 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 315730006876 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 315730006877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730006878 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 315730006879 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315730006880 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730006881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730006882 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730006883 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 315730006884 thymidylate synthase; Region: thym_sym; TIGR03284 315730006885 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 315730006886 dimerization interface [polypeptide binding]; other site 315730006887 active site 315730006888 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 315730006889 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 315730006890 folate binding site [chemical binding]; other site 315730006891 NADP+ binding site [chemical binding]; other site 315730006892 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315730006893 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730006894 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730006895 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730006896 azoreductase; Reviewed; Region: PRK00170 315730006897 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730006898 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 315730006899 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315730006900 putative acyl-acceptor binding pocket; other site 315730006901 Haemolysin-III related; Region: HlyIII; cl03831 315730006902 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 315730006903 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 315730006904 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 315730006905 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 315730006906 EDD domain protein, DegV family; Region: DegV; TIGR00762 315730006907 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315730006908 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315730006909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730006910 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 315730006911 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 315730006912 Cu(I) binding site [ion binding]; other site 315730006913 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 315730006914 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315730006915 putative dimer interface [polypeptide binding]; other site 315730006916 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 315730006917 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730006918 active site 315730006919 dimer interface [polypeptide binding]; other site 315730006920 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730006921 Ligand Binding Site [chemical binding]; other site 315730006922 Molecular Tunnel; other site 315730006923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730006924 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730006925 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730006926 active site 315730006927 metal binding site [ion binding]; metal-binding site 315730006928 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730006929 Bacterial SH3 domain; Region: SH3_3; cl17532 315730006930 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730006931 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730006932 siderophore binding site; other site 315730006933 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315730006934 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730006935 homodimer interface [polypeptide binding]; other site 315730006936 substrate-cofactor binding pocket; other site 315730006937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006938 catalytic residue [active] 315730006939 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 315730006940 FMN binding site [chemical binding]; other site 315730006941 dimer interface [polypeptide binding]; other site 315730006942 Isochorismatase family; Region: Isochorismatase; pfam00857 315730006943 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315730006944 catalytic triad [active] 315730006945 conserved cis-peptide bond; other site 315730006946 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730006947 nudix motif; other site 315730006948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 315730006949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315730006950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 315730006951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730006952 Histidine kinase; Region: HisKA_3; pfam07730 315730006953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730006954 ATP binding site [chemical binding]; other site 315730006955 Mg2+ binding site [ion binding]; other site 315730006956 G-X-G motif; other site 315730006957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730006959 active site 315730006960 phosphorylation site [posttranslational modification] 315730006961 intermolecular recognition site; other site 315730006962 dimerization interface [polypeptide binding]; other site 315730006963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730006964 DNA binding residues [nucleotide binding] 315730006965 dimerization interface [polypeptide binding]; other site 315730006966 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315730006967 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315730006968 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315730006969 putative active site [active] 315730006970 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 315730006971 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 315730006972 NAD binding site [chemical binding]; other site 315730006973 substrate binding site [chemical binding]; other site 315730006974 catalytic Zn binding site [ion binding]; other site 315730006975 tetramer interface [polypeptide binding]; other site 315730006976 structural Zn binding site [ion binding]; other site 315730006977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730006978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730006979 dimer interface [polypeptide binding]; other site 315730006980 conserved gate region; other site 315730006981 ABC-ATPase subunit interface; other site 315730006982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730006983 dimer interface [polypeptide binding]; other site 315730006984 conserved gate region; other site 315730006985 putative PBP binding loops; other site 315730006986 ABC-ATPase subunit interface; other site 315730006987 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315730006988 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315730006989 N- and C-terminal domain interface [polypeptide binding]; other site 315730006990 active site 315730006991 catalytic site [active] 315730006992 metal binding site [ion binding]; metal-binding site 315730006993 carbohydrate binding site [chemical binding]; other site 315730006994 ATP binding site [chemical binding]; other site 315730006995 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315730006996 GntP family permease; Region: GntP_permease; pfam02447 315730006997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 315730006998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315730006999 Predicted flavoprotein [General function prediction only]; Region: COG0431 315730007000 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730007001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007002 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730007003 putative substrate translocation pore; other site 315730007004 Uncharacterized conserved protein [Function unknown]; Region: COG1434 315730007005 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730007006 putative active site [active] 315730007007 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 315730007008 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 315730007009 Walker A/P-loop; other site 315730007010 ATP binding site [chemical binding]; other site 315730007011 Q-loop/lid; other site 315730007012 ABC transporter signature motif; other site 315730007013 Walker B; other site 315730007014 D-loop; other site 315730007015 H-loop/switch region; other site 315730007016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730007017 dimer interface [polypeptide binding]; other site 315730007018 conserved gate region; other site 315730007019 ABC-ATPase subunit interface; other site 315730007020 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 315730007021 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315730007022 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 315730007023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 315730007024 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 315730007025 Haemagglutinin; Region: Hemagglutinin; pfam00509 315730007026 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730007027 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730007028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730007029 Transporter associated domain; Region: CorC_HlyC; smart01091 315730007030 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 315730007031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730007032 NAD(P) binding site [chemical binding]; other site 315730007033 catalytic residues [active] 315730007034 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 315730007035 Histidine kinase N terminal; Region: HisK_N; pfam09385 315730007036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007038 dimer interface [polypeptide binding]; other site 315730007039 phosphorylation site [posttranslational modification] 315730007040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007041 ATP binding site [chemical binding]; other site 315730007042 Mg2+ binding site [ion binding]; other site 315730007043 G-X-G motif; other site 315730007044 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315730007045 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315730007046 hypothetical protein; Provisional; Region: PRK06917 315730007047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730007048 inhibitor-cofactor binding pocket; inhibition site 315730007049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007050 catalytic residue [active] 315730007051 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 315730007052 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 315730007053 acetylornithine deacetylase; Validated; Region: PRK06915 315730007054 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 315730007055 metal binding site [ion binding]; metal-binding site 315730007056 dimer interface [polypeptide binding]; other site 315730007057 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 315730007058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730007059 PAS fold; Region: PAS_4; pfam08448 315730007060 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315730007061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730007062 Walker A motif; other site 315730007063 ATP binding site [chemical binding]; other site 315730007064 Walker B motif; other site 315730007065 arginine finger; other site 315730007066 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315730007067 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 315730007068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730007069 FeS/SAM binding site; other site 315730007070 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 315730007071 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 315730007072 toxin interface [polypeptide binding]; other site 315730007073 Zn binding site [ion binding]; other site 315730007074 hypothetical protein; Provisional; Region: PRK13672 315730007075 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 315730007076 YozD-like protein; Region: YozD; pfam14162 315730007077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315730007078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315730007079 active site 315730007080 ATP binding site [chemical binding]; other site 315730007081 substrate binding site [chemical binding]; other site 315730007082 activation loop (A-loop); other site 315730007083 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 315730007084 SpoOM protein; Region: Spo0M; pfam07070 315730007085 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315730007086 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315730007087 active site 315730007088 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730007089 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 315730007090 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730007091 catalytic residues [active] 315730007092 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730007093 MepB protein; Region: MepB; pfam08877 315730007094 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 315730007095 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730007096 active site 315730007097 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 315730007098 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 315730007099 YolD-like protein; Region: YolD; pfam08863 315730007100 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730007101 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 315730007102 classical (c) SDRs; Region: SDR_c; cd05233 315730007103 NAD(P) binding site [chemical binding]; other site 315730007104 active site 315730007105 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 315730007106 KTSC domain; Region: KTSC; pfam13619 315730007107 Transglycosylase; Region: Transgly; pfam00912 315730007108 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730007109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730007110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730007112 putative substrate translocation pore; other site 315730007113 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 315730007114 dimer interface [polypeptide binding]; other site 315730007115 Citrate synthase; Region: Citrate_synt; pfam00285 315730007116 active site 315730007117 coenzyme A binding site [chemical binding]; other site 315730007118 citrylCoA binding site [chemical binding]; other site 315730007119 oxalacetate/citrate binding site [chemical binding]; other site 315730007120 catalytic triad [active] 315730007121 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 315730007122 2-methylcitrate dehydratase; Region: prpD; TIGR02330 315730007123 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315730007124 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 315730007125 tetramer interface [polypeptide binding]; other site 315730007126 active site 315730007127 Mg2+/Mn2+ binding site [ion binding]; other site 315730007128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730007129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730007130 active site 315730007131 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315730007132 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315730007133 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315730007134 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 315730007135 tetrameric interface [polypeptide binding]; other site 315730007136 NAD binding site [chemical binding]; other site 315730007137 catalytic residues [active] 315730007138 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 315730007139 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 315730007140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730007141 substrate binding site [chemical binding]; other site 315730007142 oxyanion hole (OAH) forming residues; other site 315730007143 trimer interface [polypeptide binding]; other site 315730007144 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 315730007145 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 315730007146 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315730007147 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315730007148 active site 315730007149 metal binding site [ion binding]; metal-binding site 315730007150 DNA binding site [nucleotide binding] 315730007151 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 315730007152 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 315730007153 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 315730007154 Walker A/P-loop; other site 315730007155 ATP binding site [chemical binding]; other site 315730007156 Q-loop/lid; other site 315730007157 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 315730007158 ABC transporter signature motif; other site 315730007159 Walker B; other site 315730007160 D-loop; other site 315730007161 H-loop/switch region; other site 315730007162 Chitin binding domain; Region: Chitin_bind_3; pfam03067 315730007163 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007164 Interdomain contacts; other site 315730007165 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 315730007166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007167 Interdomain contacts; other site 315730007168 Cytokine receptor motif; other site 315730007169 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 315730007170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730007171 alanine racemase; Reviewed; Region: alr; PRK00053 315730007172 active site 315730007173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730007174 dimer interface [polypeptide binding]; other site 315730007175 substrate binding site [chemical binding]; other site 315730007176 catalytic residues [active] 315730007177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730007178 dimerization interface [polypeptide binding]; other site 315730007179 putative DNA binding site [nucleotide binding]; other site 315730007180 putative Zn2+ binding site [ion binding]; other site 315730007181 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 315730007182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007183 putative substrate translocation pore; other site 315730007184 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 315730007185 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 315730007186 putative NAD(P) binding site [chemical binding]; other site 315730007187 active site 315730007188 isochorismate synthase DhbC; Validated; Region: PRK06923 315730007189 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 315730007190 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 315730007191 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 315730007192 acyl-activating enzyme (AAE) consensus motif; other site 315730007193 active site 315730007194 AMP binding site [chemical binding]; other site 315730007195 substrate binding site [chemical binding]; other site 315730007196 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 315730007197 hydrophobic substrate binding pocket; other site 315730007198 Isochorismatase family; Region: Isochorismatase; pfam00857 315730007199 active site 315730007200 conserved cis-peptide bond; other site 315730007201 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 315730007202 Condensation domain; Region: Condensation; pfam00668 315730007203 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730007204 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 315730007205 acyl-activating enzyme (AAE) consensus motif; other site 315730007206 AMP binding site [chemical binding]; other site 315730007207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730007208 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 315730007209 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730007210 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 315730007211 acyl-activating enzyme (AAE) consensus motif; other site 315730007212 AMP binding site [chemical binding]; other site 315730007213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 315730007214 MbtH-like protein; Region: MbtH; pfam03621 315730007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730007217 putative substrate translocation pore; other site 315730007218 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 315730007219 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 315730007220 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730007221 IHF dimer interface [polypeptide binding]; other site 315730007222 IHF - DNA interface [nucleotide binding]; other site 315730007223 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 315730007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 315730007225 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730007226 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730007227 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730007228 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730007229 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 315730007230 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730007231 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730007232 RNA binding surface [nucleotide binding]; other site 315730007233 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 315730007234 probable active site [active] 315730007235 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 315730007236 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315730007237 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315730007238 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315730007239 active site 315730007240 dimer interface [polypeptide binding]; other site 315730007241 motif 1; other site 315730007242 motif 2; other site 315730007243 motif 3; other site 315730007244 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315730007245 anticodon binding site; other site 315730007246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730007247 salt bridge; other site 315730007248 non-specific DNA binding site [nucleotide binding]; other site 315730007249 sequence-specific DNA binding site [nucleotide binding]; other site 315730007250 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 315730007251 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007252 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007253 Walker A/P-loop; other site 315730007254 ATP binding site [chemical binding]; other site 315730007255 Q-loop/lid; other site 315730007256 ABC transporter signature motif; other site 315730007257 Walker B; other site 315730007258 D-loop; other site 315730007259 H-loop/switch region; other site 315730007260 FtsX-like permease family; Region: FtsX; pfam02687 315730007261 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730007262 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 315730007263 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730007264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730007265 pyruvate oxidase; Provisional; Region: PRK08611 315730007266 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 315730007267 PYR/PP interface [polypeptide binding]; other site 315730007268 dimer interface [polypeptide binding]; other site 315730007269 tetramer interface [polypeptide binding]; other site 315730007270 TPP binding site [chemical binding]; other site 315730007271 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315730007272 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 315730007273 TPP-binding site [chemical binding]; other site 315730007274 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 315730007275 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730007276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730007277 metal-binding site [ion binding] 315730007278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730007279 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730007280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730007281 dimerization interface [polypeptide binding]; other site 315730007282 putative DNA binding site [nucleotide binding]; other site 315730007283 putative Zn2+ binding site [ion binding]; other site 315730007284 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730007285 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730007286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730007287 Transporter associated domain; Region: CorC_HlyC; smart01091 315730007288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730007289 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 315730007290 active site 315730007291 dimerization interface [polypeptide binding]; other site 315730007292 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 315730007293 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315730007294 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730007295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730007296 ligand binding site [chemical binding]; other site 315730007297 flexible hinge region; other site 315730007298 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 315730007299 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315730007300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730007301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730007302 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 315730007303 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 315730007304 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730007305 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 315730007306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007307 Coenzyme A binding pocket [chemical binding]; other site 315730007308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730007309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007311 MMPL family; Region: MMPL; pfam03176 315730007312 MMPL family; Region: MMPL; pfam03176 315730007313 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 315730007314 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 315730007315 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 315730007316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730007318 Coenzyme A binding pocket [chemical binding]; other site 315730007319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730007320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007321 Coenzyme A binding pocket [chemical binding]; other site 315730007322 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315730007323 putative acetyltransferase YhhY; Provisional; Region: PRK10140 315730007324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007325 Coenzyme A binding pocket [chemical binding]; other site 315730007326 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730007327 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730007328 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730007329 EamA-like transporter family; Region: EamA; pfam00892 315730007330 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730007331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730007332 non-specific DNA binding site [nucleotide binding]; other site 315730007333 salt bridge; other site 315730007334 sequence-specific DNA binding site [nucleotide binding]; other site 315730007335 Cupin domain; Region: Cupin_2; pfam07883 315730007336 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730007337 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730007338 protoporphyrinogen oxidase; Provisional; Region: PRK12416 315730007339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730007340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730007341 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730007342 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730007343 Cold-inducible protein YdjO; Region: YdjO; pfam14169 315730007344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730007345 DNA-binding site [nucleotide binding]; DNA binding site 315730007346 RNA-binding motif; other site 315730007347 CAAX protease self-immunity; Region: Abi; pfam02517 315730007348 AAA domain; Region: AAA_17; pfam13207 315730007349 AAA domain; Region: AAA_18; pfam13238 315730007350 hypothetical protein; Provisional; Region: PRK06770 315730007351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730007352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730007353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730007354 dimerization interface [polypeptide binding]; other site 315730007355 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 315730007356 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 315730007357 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 315730007358 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 315730007359 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 315730007360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730007361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730007362 dimerization interface [polypeptide binding]; other site 315730007363 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 315730007364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730007365 inhibitor-cofactor binding pocket; inhibition site 315730007366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007367 catalytic residue [active] 315730007368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315730007369 MOSC domain; Region: MOSC; pfam03473 315730007370 3-alpha domain; Region: 3-alpha; pfam03475 315730007371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007372 Coenzyme A binding pocket [chemical binding]; other site 315730007373 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 315730007374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730007376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007377 Walker A/P-loop; other site 315730007378 ATP binding site [chemical binding]; other site 315730007379 Q-loop/lid; other site 315730007380 ABC transporter signature motif; other site 315730007381 Walker B; other site 315730007382 D-loop; other site 315730007383 H-loop/switch region; other site 315730007384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730007386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007387 Walker A/P-loop; other site 315730007388 ATP binding site [chemical binding]; other site 315730007389 Q-loop/lid; other site 315730007390 ABC transporter signature motif; other site 315730007391 Walker B; other site 315730007392 D-loop; other site 315730007393 H-loop/switch region; other site 315730007394 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 315730007395 LysE type translocator; Region: LysE; cl00565 315730007396 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730007397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730007398 non-specific DNA binding site [nucleotide binding]; other site 315730007399 salt bridge; other site 315730007400 sequence-specific DNA binding site [nucleotide binding]; other site 315730007401 Cupin domain; Region: Cupin_2; pfam07883 315730007402 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 315730007403 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 315730007404 BclB C-terminal domain; Region: exospore_TM; TIGR03721 315730007405 Cupin; Region: Cupin_1; smart00835 315730007406 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315730007407 HD domain; Region: HD_4; pfam13328 315730007408 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 315730007409 metal binding triad [ion binding]; metal-binding site 315730007410 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315730007411 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 315730007412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730007413 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 315730007414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730007415 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730007416 DNA binding residues [nucleotide binding] 315730007417 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315730007418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007419 S-adenosylmethionine binding site [chemical binding]; other site 315730007420 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315730007421 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 315730007422 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 315730007423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 315730007424 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730007425 active site 315730007426 P-loop; other site 315730007427 phosphorylation site [posttranslational modification] 315730007428 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 315730007429 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730007430 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 315730007431 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 315730007432 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315730007433 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 315730007434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 315730007435 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 315730007436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730007437 catalytic residue [active] 315730007438 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 315730007439 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 315730007440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730007441 ATP binding site [chemical binding]; other site 315730007442 Mg++ binding site [ion binding]; other site 315730007443 motif III; other site 315730007444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730007445 nucleotide binding region [chemical binding]; other site 315730007446 ATP-binding site [chemical binding]; other site 315730007447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007450 putative substrate translocation pore; other site 315730007451 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730007452 FtsX-like permease family; Region: FtsX; pfam02687 315730007453 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730007454 FtsX-like permease family; Region: FtsX; pfam02687 315730007455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007457 Walker A/P-loop; other site 315730007458 ATP binding site [chemical binding]; other site 315730007459 Q-loop/lid; other site 315730007460 ABC transporter signature motif; other site 315730007461 Walker B; other site 315730007462 D-loop; other site 315730007463 H-loop/switch region; other site 315730007464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730007465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007466 S-adenosylmethionine binding site [chemical binding]; other site 315730007467 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730007468 dimer interface [polypeptide binding]; other site 315730007469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730007470 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315730007471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 315730007472 conserved cys residue [active] 315730007473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730007474 MarR family; Region: MarR_2; pfam12802 315730007475 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730007476 catalytic core [active] 315730007477 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730007478 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 315730007479 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730007480 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 315730007481 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 315730007482 metal binding site [ion binding]; metal-binding site 315730007483 dimer interface [polypeptide binding]; other site 315730007484 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730007485 trimer interface [polypeptide binding]; other site 315730007486 active site 315730007487 substrate binding site [chemical binding]; other site 315730007488 CoA binding site [chemical binding]; other site 315730007489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007491 active site 315730007492 phosphorylation site [posttranslational modification] 315730007493 intermolecular recognition site; other site 315730007494 dimerization interface [polypeptide binding]; other site 315730007495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007496 DNA binding site [nucleotide binding] 315730007497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007498 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 315730007499 dimer interface [polypeptide binding]; other site 315730007500 phosphorylation site [posttranslational modification] 315730007501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007502 ATP binding site [chemical binding]; other site 315730007503 Mg2+ binding site [ion binding]; other site 315730007504 G-X-G motif; other site 315730007505 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007507 Walker A/P-loop; other site 315730007508 ATP binding site [chemical binding]; other site 315730007509 Q-loop/lid; other site 315730007510 ABC transporter signature motif; other site 315730007511 Walker B; other site 315730007512 D-loop; other site 315730007513 H-loop/switch region; other site 315730007514 hypothetical protein; Provisional; Region: PRK12473 315730007515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007516 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007517 Walker A/P-loop; other site 315730007518 ATP binding site [chemical binding]; other site 315730007519 Q-loop/lid; other site 315730007520 ABC transporter signature motif; other site 315730007521 Walker B; other site 315730007522 D-loop; other site 315730007523 H-loop/switch region; other site 315730007524 FtsX-like permease family; Region: FtsX; pfam02687 315730007525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007527 active site 315730007528 phosphorylation site [posttranslational modification] 315730007529 intermolecular recognition site; other site 315730007530 dimerization interface [polypeptide binding]; other site 315730007531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007532 DNA binding site [nucleotide binding] 315730007533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730007535 dimerization interface [polypeptide binding]; other site 315730007536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007537 dimer interface [polypeptide binding]; other site 315730007538 phosphorylation site [posttranslational modification] 315730007539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007540 ATP binding site [chemical binding]; other site 315730007541 Mg2+ binding site [ion binding]; other site 315730007542 G-X-G motif; other site 315730007543 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730007544 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730007545 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 315730007546 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 315730007547 lysozyme catalytic site [active] 315730007548 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 315730007549 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 315730007550 active site 315730007551 catalytic triad [active] 315730007552 oxyanion hole [active] 315730007553 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315730007554 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730007555 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730007557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007559 active site 315730007560 phosphorylation site [posttranslational modification] 315730007561 intermolecular recognition site; other site 315730007562 dimerization interface [polypeptide binding]; other site 315730007563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007564 DNA binding site [nucleotide binding] 315730007565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007566 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 315730007567 dimer interface [polypeptide binding]; other site 315730007568 phosphorylation site [posttranslational modification] 315730007569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007570 ATP binding site [chemical binding]; other site 315730007571 Mg2+ binding site [ion binding]; other site 315730007572 G-X-G motif; other site 315730007573 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007574 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007575 Walker A/P-loop; other site 315730007576 ATP binding site [chemical binding]; other site 315730007577 Q-loop/lid; other site 315730007578 ABC transporter signature motif; other site 315730007579 Walker B; other site 315730007580 D-loop; other site 315730007581 H-loop/switch region; other site 315730007582 FtsX-like permease family; Region: FtsX; pfam02687 315730007583 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730007584 hypothetical protein; Provisional; Region: PRK06760 315730007585 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730007586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730007587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730007588 DNA binding residues [nucleotide binding] 315730007589 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730007590 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730007592 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730007593 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007594 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730007596 beta-lactamase TEM; Provisional; Region: PRK15442 315730007597 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315730007598 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007599 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007600 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007601 Peptidase M60-like family; Region: M60-like; pfam13402 315730007602 Viral enhancin protein; Region: Enhancin; pfam03272 315730007603 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 315730007604 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730007605 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730007606 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730007607 active site residue [active] 315730007608 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730007609 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730007610 Spore germination protein; Region: Spore_permease; cl17796 315730007611 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730007612 Fic family protein [Function unknown]; Region: COG3177 315730007613 Fic/DOC family; Region: Fic; pfam02661 315730007614 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730007615 dimerization interface [polypeptide binding]; other site 315730007616 putative DNA binding site [nucleotide binding]; other site 315730007617 putative Zn2+ binding site [ion binding]; other site 315730007618 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730007619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 315730007622 Chitin binding domain; Region: Chitin_bind_3; pfam03067 315730007623 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007624 Interdomain contacts; other site 315730007625 Cytokine receptor motif; other site 315730007626 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007627 Interdomain contacts; other site 315730007628 Cytokine receptor motif; other site 315730007629 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 315730007630 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 315730007631 active site 315730007632 catalytic site [active] 315730007633 putative metal binding site [ion binding]; other site 315730007634 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730007635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730007636 putative active site [active] 315730007637 putative metal binding site [ion binding]; other site 315730007638 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730007639 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730007640 Walker A/P-loop; other site 315730007641 ATP binding site [chemical binding]; other site 315730007642 Q-loop/lid; other site 315730007643 ABC transporter signature motif; other site 315730007644 Walker B; other site 315730007645 D-loop; other site 315730007646 H-loop/switch region; other site 315730007647 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 315730007648 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 315730007649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007651 Protein of unknown function (DUF523); Region: DUF523; pfam04463 315730007652 Uncharacterized conserved protein [Function unknown]; Region: COG3272 315730007653 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 315730007654 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730007655 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730007656 FAD binding site [chemical binding]; other site 315730007657 homotetramer interface [polypeptide binding]; other site 315730007658 substrate binding pocket [chemical binding]; other site 315730007659 catalytic base [active] 315730007660 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 315730007661 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730007662 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315730007663 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315730007664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730007665 carboxyltransferase (CT) interaction site; other site 315730007666 biotinylation site [posttranslational modification]; other site 315730007667 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 315730007668 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 315730007669 active site 315730007670 catalytic residues [active] 315730007671 metal binding site [ion binding]; metal-binding site 315730007672 enoyl-CoA hydratase; Provisional; Region: PRK07657 315730007673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730007674 substrate binding site [chemical binding]; other site 315730007675 oxyanion hole (OAH) forming residues; other site 315730007676 trimer interface [polypeptide binding]; other site 315730007677 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 315730007678 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 315730007679 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 315730007680 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315730007681 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 315730007682 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 315730007683 acyl-activating enzyme (AAE) consensus motif; other site 315730007684 putative AMP binding site [chemical binding]; other site 315730007685 putative active site [active] 315730007686 putative CoA binding site [chemical binding]; other site 315730007687 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 315730007688 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 315730007689 Septum formation initiator; Region: DivIC; pfam04977 315730007690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730007691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007692 Coenzyme A binding pocket [chemical binding]; other site 315730007693 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 315730007694 hypothetical protein; Provisional; Region: PRK08233 315730007695 active site 315730007696 DinB family; Region: DinB; cl17821 315730007697 DinB superfamily; Region: DinB_2; pfam12867 315730007698 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730007699 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730007700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007702 dimer interface [polypeptide binding]; other site 315730007703 phosphorylation site [posttranslational modification] 315730007704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007705 ATP binding site [chemical binding]; other site 315730007706 Mg2+ binding site [ion binding]; other site 315730007707 G-X-G motif; other site 315730007708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007710 active site 315730007711 phosphorylation site [posttranslational modification] 315730007712 intermolecular recognition site; other site 315730007713 dimerization interface [polypeptide binding]; other site 315730007714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007715 DNA binding site [nucleotide binding] 315730007716 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 315730007717 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 315730007718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007719 Coenzyme A binding pocket [chemical binding]; other site 315730007720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007721 Coenzyme A binding pocket [chemical binding]; other site 315730007722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 315730007723 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 315730007724 putative hydrophobic ligand binding site [chemical binding]; other site 315730007725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007726 AAA domain; Region: AAA_21; pfam13304 315730007727 Walker A/P-loop; other site 315730007728 ATP binding site [chemical binding]; other site 315730007729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007730 ABC transporter signature motif; other site 315730007731 Walker B; other site 315730007732 D-loop; other site 315730007733 H-loop/switch region; other site 315730007734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007735 Walker A/P-loop; other site 315730007736 ATP binding site [chemical binding]; other site 315730007737 Q-loop/lid; other site 315730007738 ABC transporter signature motif; other site 315730007739 Walker B; other site 315730007740 D-loop; other site 315730007741 H-loop/switch region; other site 315730007742 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730007743 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730007744 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 315730007745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730007746 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730007747 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730007748 nudix motif; other site 315730007749 short chain dehydrogenase; Provisional; Region: PRK07041 315730007750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007751 NAD(P) binding site [chemical binding]; other site 315730007752 active site 315730007753 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730007754 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315730007755 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730007756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007757 S-adenosylmethionine binding site [chemical binding]; other site 315730007758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315730007759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730007760 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730007761 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730007762 active site 315730007763 Phosphotransferase enzyme family; Region: APH; pfam01636 315730007764 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730007765 active site 315730007766 substrate binding site [chemical binding]; other site 315730007767 ATP binding site [chemical binding]; other site 315730007768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007770 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315730007771 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315730007772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730007773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730007774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730007775 Cupin domain; Region: Cupin_2; cl17218 315730007776 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 315730007777 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730007778 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730007779 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730007780 active site 315730007781 Zn binding site [ion binding]; other site 315730007782 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730007783 EamA-like transporter family; Region: EamA; pfam00892 315730007784 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007786 DNA-binding site [nucleotide binding]; DNA binding site 315730007787 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007789 homodimer interface [polypeptide binding]; other site 315730007790 catalytic residue [active] 315730007791 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730007792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730007793 active site 315730007794 CAAX protease self-immunity; Region: Abi; pfam02517 315730007795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007796 Predicted membrane protein [Function unknown]; Region: COG2323 315730007797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730007799 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 315730007800 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007802 DNA-binding site [nucleotide binding]; DNA binding site 315730007803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007805 homodimer interface [polypeptide binding]; other site 315730007806 catalytic residue [active] 315730007807 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 315730007808 EamA-like transporter family; Region: EamA; pfam00892 315730007809 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 315730007810 Uncharacterized conserved protein [Function unknown]; Region: COG2128 315730007811 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 315730007812 SecY translocase; Region: SecY; pfam00344 315730007813 DinB superfamily; Region: DinB_2; pfam12867 315730007814 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 315730007815 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730007816 active site 315730007817 metal binding site [ion binding]; metal-binding site 315730007818 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730007819 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730007820 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730007821 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730007822 active site 315730007823 Zn binding site [ion binding]; other site 315730007824 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 315730007825 carbohydrate binding site [chemical binding]; other site 315730007826 pullulanase, type I; Region: pulA_typeI; TIGR02104 315730007827 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 315730007828 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 315730007829 Ca binding site [ion binding]; other site 315730007830 active site 315730007831 catalytic site [active] 315730007832 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 315730007833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730007834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730007835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007836 Coenzyme A binding pocket [chemical binding]; other site 315730007837 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730007838 FtsX-like permease family; Region: FtsX; pfam02687 315730007839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730007841 Walker A/P-loop; other site 315730007842 ATP binding site [chemical binding]; other site 315730007843 Q-loop/lid; other site 315730007844 ABC transporter signature motif; other site 315730007845 Walker B; other site 315730007846 D-loop; other site 315730007847 H-loop/switch region; other site 315730007848 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315730007849 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730007850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730007851 dimerization interface [polypeptide binding]; other site 315730007852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007853 dimer interface [polypeptide binding]; other site 315730007854 phosphorylation site [posttranslational modification] 315730007855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007856 ATP binding site [chemical binding]; other site 315730007857 Mg2+ binding site [ion binding]; other site 315730007858 G-X-G motif; other site 315730007859 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 315730007860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007861 active site 315730007862 phosphorylation site [posttranslational modification] 315730007863 intermolecular recognition site; other site 315730007864 dimerization interface [polypeptide binding]; other site 315730007865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007866 DNA binding site [nucleotide binding] 315730007867 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 315730007868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730007869 motif II; other site 315730007870 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 315730007871 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 315730007872 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 315730007873 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730007874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730007875 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 315730007876 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 315730007877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730007879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007880 Walker A/P-loop; other site 315730007881 ATP binding site [chemical binding]; other site 315730007882 Q-loop/lid; other site 315730007883 ABC transporter signature motif; other site 315730007884 Walker B; other site 315730007885 D-loop; other site 315730007886 H-loop/switch region; other site 315730007887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730007889 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 315730007890 Walker A/P-loop; other site 315730007891 ATP binding site [chemical binding]; other site 315730007892 Q-loop/lid; other site 315730007893 ABC transporter signature motif; other site 315730007894 Walker B; other site 315730007895 D-loop; other site 315730007896 H-loop/switch region; other site 315730007897 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 315730007898 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 315730007899 dimer interface [polypeptide binding]; other site 315730007900 PYR/PP interface [polypeptide binding]; other site 315730007901 TPP binding site [chemical binding]; other site 315730007902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 315730007903 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 315730007904 TPP-binding site [chemical binding]; other site 315730007905 dimer interface [polypeptide binding]; other site 315730007906 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 315730007907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730007908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007909 Coenzyme A binding pocket [chemical binding]; other site 315730007910 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730007911 GIY-YIG motif/motif A; other site 315730007912 active site 315730007913 catalytic site [active] 315730007914 putative DNA binding site [nucleotide binding]; other site 315730007915 metal binding site [ion binding]; metal-binding site 315730007916 Bacitracin resistance protein BacA; Region: BacA; pfam02673 315730007917 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 315730007918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730007919 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730007920 metal-dependent hydrolase; Provisional; Region: PRK13291 315730007921 DinB superfamily; Region: DinB_2; pfam12867 315730007922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007923 Coenzyme A binding pocket [chemical binding]; other site 315730007924 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 315730007925 pentamer interface [polypeptide binding]; other site 315730007926 dodecaamer interface [polypeptide binding]; other site 315730007927 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 315730007928 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 315730007929 active site 315730007930 nucleophile elbow; other site 315730007931 YxiJ-like protein; Region: YxiJ; pfam14176 315730007932 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 315730007933 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 315730007934 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315730007935 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 315730007936 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 315730007937 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730007938 homotrimer interaction site [polypeptide binding]; other site 315730007939 putative active site [active] 315730007940 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315730007941 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 315730007942 DNA polymerase III subunit beta; Validated; Region: PRK06673 315730007943 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315730007944 putative DNA binding surface [nucleotide binding]; other site 315730007945 dimer interface [polypeptide binding]; other site 315730007946 beta-clamp/clamp loader binding surface; other site 315730007947 beta-clamp/translesion DNA polymerase binding surface; other site 315730007948 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730007949 nudix motif; other site 315730007950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 315730007951 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 315730007952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007953 putative substrate translocation pore; other site 315730007954 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730007955 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730007956 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 315730007957 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 315730007958 nudix motif; other site 315730007959 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 315730007960 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730007961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007962 Coenzyme A binding pocket [chemical binding]; other site 315730007963 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730007964 active site 315730007965 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730007966 EamA-like transporter family; Region: EamA; pfam00892 315730007967 EamA-like transporter family; Region: EamA; pfam00892 315730007968 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007970 DNA-binding site [nucleotide binding]; DNA binding site 315730007971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007973 homodimer interface [polypeptide binding]; other site 315730007974 catalytic residue [active] 315730007975 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 315730007976 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 315730007977 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730007978 active site 315730007979 catalytic site [active] 315730007980 metal binding site [ion binding]; metal-binding site 315730007981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730007983 Coenzyme A binding pocket [chemical binding]; other site 315730007984 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730007985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730007986 putative DNA binding site [nucleotide binding]; other site 315730007987 dimerization interface [polypeptide binding]; other site 315730007988 putative Zn2+ binding site [ion binding]; other site 315730007989 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 315730007990 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 315730007991 NADP binding site [chemical binding]; other site 315730007992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730007994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730007995 Walker A/P-loop; other site 315730007996 ATP binding site [chemical binding]; other site 315730007997 Q-loop/lid; other site 315730007998 ABC transporter signature motif; other site 315730007999 Walker B; other site 315730008000 D-loop; other site 315730008001 H-loop/switch region; other site 315730008002 EDD domain protein, DegV family; Region: DegV; TIGR00762 315730008003 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315730008004 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 315730008005 VanZ like family; Region: VanZ; pfam04892 315730008006 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730008007 Beta-lactamase; Region: Beta-lactamase; cl17358 315730008008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008009 putative substrate translocation pore; other site 315730008010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008011 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730008012 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008013 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730008014 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315730008015 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315730008016 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315730008017 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315730008018 active site 315730008019 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730008020 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 315730008021 NAD(P) binding site [chemical binding]; other site 315730008022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730008024 dimerization interface [polypeptide binding]; other site 315730008025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008026 dimer interface [polypeptide binding]; other site 315730008027 phosphorylation site [posttranslational modification] 315730008028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008029 ATP binding site [chemical binding]; other site 315730008030 Mg2+ binding site [ion binding]; other site 315730008031 G-X-G motif; other site 315730008032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008034 active site 315730008035 phosphorylation site [posttranslational modification] 315730008036 intermolecular recognition site; other site 315730008037 dimerization interface [polypeptide binding]; other site 315730008038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008039 DNA binding site [nucleotide binding] 315730008040 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315730008041 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 315730008042 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315730008043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008045 dimer interface [polypeptide binding]; other site 315730008046 phosphorylation site [posttranslational modification] 315730008047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008048 ATP binding site [chemical binding]; other site 315730008049 Mg2+ binding site [ion binding]; other site 315730008050 G-X-G motif; other site 315730008051 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315730008052 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730008053 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315730008054 Walker A/P-loop; other site 315730008055 ATP binding site [chemical binding]; other site 315730008056 Q-loop/lid; other site 315730008057 ABC transporter signature motif; other site 315730008058 Walker B; other site 315730008059 D-loop; other site 315730008060 H-loop/switch region; other site 315730008061 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 315730008062 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730008063 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315730008064 Walker A/P-loop; other site 315730008065 ATP binding site [chemical binding]; other site 315730008066 Q-loop/lid; other site 315730008067 ABC transporter signature motif; other site 315730008068 Walker B; other site 315730008069 D-loop; other site 315730008070 H-loop/switch region; other site 315730008071 hypothetical protein; Provisional; Region: PRK13661 315730008072 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 315730008073 aspartate racemase; Region: asp_race; TIGR00035 315730008074 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730008075 homodimer interface [polypeptide binding]; other site 315730008076 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730008077 active site 315730008078 TDP-binding site; other site 315730008079 acceptor substrate-binding pocket; other site 315730008080 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730008081 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730008082 Catalytic site [active] 315730008083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730008084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730008087 PAS domain S-box; Region: sensory_box; TIGR00229 315730008088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730008089 putative active site [active] 315730008090 heme pocket [chemical binding]; other site 315730008091 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730008092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008093 dimer interface [polypeptide binding]; other site 315730008094 phosphorylation site [posttranslational modification] 315730008095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008096 ATP binding site [chemical binding]; other site 315730008097 Mg2+ binding site [ion binding]; other site 315730008098 G-X-G motif; other site 315730008099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008100 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730008101 active site 315730008102 motif I; other site 315730008103 motif II; other site 315730008104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008105 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 315730008106 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315730008107 Cytochrome P450; Region: p450; cl12078 315730008108 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730008109 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730008110 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315730008111 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730008112 trimer interface [polypeptide binding]; other site 315730008113 active site 315730008114 substrate binding site [chemical binding]; other site 315730008115 CoA binding site [chemical binding]; other site 315730008116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008117 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730008118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008119 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315730008120 Cytochrome P450; Region: p450; cl12078 315730008121 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 315730008122 Protein of unknown function; Region: DUF3658; pfam12395 315730008123 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 315730008124 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 315730008125 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 315730008126 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 315730008127 Putative transcription activator [Transcription]; Region: TenA; COG0819 315730008128 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 315730008129 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315730008130 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315730008131 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730008132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730008133 DNA-binding site [nucleotide binding]; DNA binding site 315730008134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008136 homodimer interface [polypeptide binding]; other site 315730008137 catalytic residue [active] 315730008138 homoserine dehydrogenase; Validated; Region: PRK06813 315730008139 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 315730008140 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730008141 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 315730008142 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 315730008143 hypothetical protein; Provisional; Region: PRK06760 315730008144 FtsX-like permease family; Region: FtsX; pfam02687 315730008145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730008146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730008147 Walker A/P-loop; other site 315730008148 ATP binding site [chemical binding]; other site 315730008149 Q-loop/lid; other site 315730008150 ABC transporter signature motif; other site 315730008151 Walker B; other site 315730008152 D-loop; other site 315730008153 H-loop/switch region; other site 315730008154 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315730008155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008156 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730008157 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730008158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730008159 ABC transporter; Region: ABC_tran_2; pfam12848 315730008160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730008161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730008162 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730008163 active site 315730008164 catalytic tetrad [active] 315730008165 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315730008166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730008167 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 315730008168 dimerization interface [polypeptide binding]; other site 315730008169 substrate binding pocket [chemical binding]; other site 315730008170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730008172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008173 ATP binding site [chemical binding]; other site 315730008174 Mg2+ binding site [ion binding]; other site 315730008175 G-X-G motif; other site 315730008176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008178 active site 315730008179 phosphorylation site [posttranslational modification] 315730008180 intermolecular recognition site; other site 315730008181 dimerization interface [polypeptide binding]; other site 315730008182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008183 DNA binding site [nucleotide binding] 315730008184 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 315730008185 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730008186 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730008187 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 315730008188 putative NAD(P) binding site [chemical binding]; other site 315730008189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730008190 TAP-like protein; Region: Abhydrolase_4; pfam08386 315730008191 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 315730008192 Mg binding site [ion binding]; other site 315730008193 nucleotide binding site [chemical binding]; other site 315730008194 putative protofilament interface [polypeptide binding]; other site 315730008195 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 315730008196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730008197 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315730008198 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730008199 germination protein YpeB; Region: spore_YpeB; TIGR02889 315730008200 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 315730008201 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315730008202 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730008203 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315730008204 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730008205 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730008206 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 315730008207 arylformamidase; Region: trp_arylform; TIGR03035 315730008208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730008209 kynureninase; Region: kynureninase; TIGR01814 315730008210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730008211 catalytic residue [active] 315730008212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730008214 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 315730008215 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 315730008216 GAF domain; Region: GAF; pfam01590 315730008217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730008218 Walker A motif; other site 315730008219 ATP binding site [chemical binding]; other site 315730008220 Walker B motif; other site 315730008221 arginine finger; other site 315730008222 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315730008223 NIPSNAP; Region: NIPSNAP; pfam07978 315730008224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730008225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008226 Coenzyme A binding pocket [chemical binding]; other site 315730008227 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730008228 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 315730008229 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315730008230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008231 S-adenosylmethionine binding site [chemical binding]; other site 315730008232 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730008233 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730008234 Transcriptional regulator; Region: Rrf2; pfam02082 315730008235 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 315730008236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730008237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730008238 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730008239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730008240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730008241 E3 interaction surface; other site 315730008242 lipoyl attachment site [posttranslational modification]; other site 315730008243 e3 binding domain; Region: E3_binding; pfam02817 315730008244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315730008245 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730008246 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730008247 alpha subunit interface [polypeptide binding]; other site 315730008248 TPP binding site [chemical binding]; other site 315730008249 heterodimer interface [polypeptide binding]; other site 315730008250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730008251 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315730008252 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315730008253 tetramer interface [polypeptide binding]; other site 315730008254 TPP-binding site [chemical binding]; other site 315730008255 heterodimer interface [polypeptide binding]; other site 315730008256 phosphorylation loop region [posttranslational modification] 315730008257 DinB superfamily; Region: DinB_2; pfam12867 315730008258 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 315730008259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008261 putative substrate translocation pore; other site 315730008262 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 315730008263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730008264 short chain dehydrogenase; Provisional; Region: PRK06914 315730008265 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 315730008266 NADP binding site [chemical binding]; other site 315730008267 active site 315730008268 steroid binding site; other site 315730008269 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315730008270 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 315730008271 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 315730008272 Protein phosphatase 2C; Region: PP2C_2; pfam13672 315730008273 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 315730008274 nucleotide binding site/active site [active] 315730008275 HIT family signature motif; other site 315730008276 catalytic residue [active] 315730008277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730008278 dimer interface [polypeptide binding]; other site 315730008279 conserved gate region; other site 315730008280 putative PBP binding loops; other site 315730008281 ABC-ATPase subunit interface; other site 315730008282 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 315730008283 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 315730008284 Walker A/P-loop; other site 315730008285 ATP binding site [chemical binding]; other site 315730008286 Q-loop/lid; other site 315730008287 ABC transporter signature motif; other site 315730008288 Walker B; other site 315730008289 D-loop; other site 315730008290 H-loop/switch region; other site 315730008291 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 315730008292 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 315730008293 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315730008294 Clp protease; Region: CLP_protease; pfam00574 315730008295 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315730008296 oligomer interface [polypeptide binding]; other site 315730008297 active site residues [active] 315730008298 RNA polymerase factor sigma-70; Validated; Region: PRK06704 315730008299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730008300 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730008301 DNA binding residues [nucleotide binding] 315730008302 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 315730008303 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 315730008304 catalytic loop [active] 315730008305 iron binding site [ion binding]; other site 315730008306 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 315730008307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730008308 active site 315730008309 dimer interface [polypeptide binding]; other site 315730008310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008311 Coenzyme A binding pocket [chemical binding]; other site 315730008312 Chitin binding domain; Region: Chitin_bind_3; pfam03067 315730008313 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730008314 Interdomain contacts; other site 315730008315 Cytokine receptor motif; other site 315730008316 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730008317 Interdomain contacts; other site 315730008318 Cytokine receptor motif; other site 315730008319 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 315730008320 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730008321 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730008322 active site 315730008323 TDP-binding site; other site 315730008324 acceptor substrate-binding pocket; other site 315730008325 homodimer interface [polypeptide binding]; other site 315730008326 Uncharacterized conserved protein [Function unknown]; Region: COG1262 315730008327 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 315730008328 topology modulation protein; Reviewed; Region: PRK08118 315730008329 AAA domain; Region: AAA_17; pfam13207 315730008330 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730008331 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730008332 active site 315730008333 ATP binding site [chemical binding]; other site 315730008334 substrate binding site [chemical binding]; other site 315730008335 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 315730008336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 315730008337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008338 Coenzyme A binding pocket [chemical binding]; other site 315730008339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008340 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730008341 Coenzyme A binding pocket [chemical binding]; other site 315730008342 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 315730008343 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730008344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008345 Coenzyme A binding pocket [chemical binding]; other site 315730008346 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730008347 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730008348 Protein of unknown function (DUF952); Region: DUF952; pfam06108 315730008349 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 315730008350 Part of AAA domain; Region: AAA_19; pfam13245 315730008351 Family description; Region: UvrD_C_2; pfam13538 315730008352 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730008353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008354 S-adenosylmethionine binding site [chemical binding]; other site 315730008355 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315730008356 putative active site pocket [active] 315730008357 dimerization interface [polypeptide binding]; other site 315730008358 putative catalytic residue [active] 315730008359 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 315730008360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730008361 ATP binding site [chemical binding]; other site 315730008362 putative Mg++ binding site [ion binding]; other site 315730008363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730008364 nucleotide binding region [chemical binding]; other site 315730008365 ATP-binding site [chemical binding]; other site 315730008366 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 315730008367 HRDC domain; Region: HRDC; pfam00570 315730008368 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 315730008369 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730008370 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730008371 active site 315730008372 Zn binding site [ion binding]; other site 315730008373 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 315730008374 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 315730008375 DHHA2 domain; Region: DHHA2; pfam02833 315730008376 Chitin binding domain; Region: Chitin_bind_3; pfam03067 315730008377 DinB family; Region: DinB; cl17821 315730008378 DinB superfamily; Region: DinB_2; pfam12867 315730008379 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730008380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008381 Coenzyme A binding pocket [chemical binding]; other site 315730008382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730008383 Zn2+ binding site [ion binding]; other site 315730008384 Mg2+ binding site [ion binding]; other site 315730008385 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 315730008386 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 315730008387 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730008388 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730008389 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315730008390 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730008391 NAD(P) binding site [chemical binding]; other site 315730008392 catalytic residues [active] 315730008393 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315730008394 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315730008395 inhibitor site; inhibition site 315730008396 active site 315730008397 dimer interface [polypeptide binding]; other site 315730008398 catalytic residue [active] 315730008399 Proline racemase; Region: Pro_racemase; pfam05544 315730008400 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730008401 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730008402 Proline racemase; Region: Pro_racemase; pfam05544 315730008403 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730008404 hydroxyglutarate oxidase; Provisional; Region: PRK11728 315730008405 PAS domain; Region: PAS; smart00091 315730008406 PAS domain; Region: PAS_10; pfam13596 315730008407 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 315730008408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730008409 Walker A motif; other site 315730008410 ATP binding site [chemical binding]; other site 315730008411 Walker B motif; other site 315730008412 arginine finger; other site 315730008413 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315730008414 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 315730008415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 315730008416 catalytic loop [active] 315730008417 iron binding site [ion binding]; other site 315730008418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 315730008419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730008420 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 315730008421 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315730008422 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730008423 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730008424 DinB superfamily; Region: DinB_2; pfam12867 315730008425 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315730008426 DltD N-terminal region; Region: DltD_N; pfam04915 315730008427 DltD central region; Region: DltD_M; pfam04918 315730008428 DltD C-terminal region; Region: DltD_C; pfam04914 315730008429 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730008430 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730008431 peptide binding site [polypeptide binding]; other site 315730008432 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315730008433 NlpC/P60 family; Region: NLPC_P60; pfam00877 315730008434 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315730008435 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315730008436 active site 315730008437 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 315730008438 Septum formation initiator; Region: DivIC; pfam04977 315730008439 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 315730008440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730008441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730008442 active site 315730008443 catalytic tetrad [active] 315730008444 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315730008445 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 315730008446 conserved cys residue [active] 315730008447 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730008448 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730008449 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 315730008450 lysozyme catalytic site [active] 315730008451 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730008452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008453 S-adenosylmethionine binding site [chemical binding]; other site 315730008454 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 315730008455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730008456 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 315730008457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730008459 dimerization interface [polypeptide binding]; other site 315730008460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008461 dimer interface [polypeptide binding]; other site 315730008462 phosphorylation site [posttranslational modification] 315730008463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008464 ATP binding site [chemical binding]; other site 315730008465 Mg2+ binding site [ion binding]; other site 315730008466 G-X-G motif; other site 315730008467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008469 active site 315730008470 phosphorylation site [posttranslational modification] 315730008471 intermolecular recognition site; other site 315730008472 dimerization interface [polypeptide binding]; other site 315730008473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008474 DNA binding site [nucleotide binding] 315730008475 DinB superfamily; Region: DinB_2; pfam12867 315730008476 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730008477 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730008478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008479 motif II; other site 315730008480 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 315730008481 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 315730008482 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 315730008483 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730008484 Zn binding site [ion binding]; other site 315730008485 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730008486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008487 Coenzyme A binding pocket [chemical binding]; other site 315730008488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730008489 non-specific DNA binding site [nucleotide binding]; other site 315730008490 salt bridge; other site 315730008491 sequence-specific DNA binding site [nucleotide binding]; other site 315730008492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730008493 EDD domain protein, DegV family; Region: DegV; TIGR00762 315730008494 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315730008495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008496 Coenzyme A binding pocket [chemical binding]; other site 315730008497 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 315730008498 Isochorismatase family; Region: Isochorismatase; pfam00857 315730008499 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 315730008500 catalytic triad [active] 315730008501 dimer interface [polypeptide binding]; other site 315730008502 conserved cis-peptide bond; other site 315730008503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008505 putative substrate translocation pore; other site 315730008506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008507 putative substrate translocation pore; other site 315730008508 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 315730008509 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 315730008510 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 315730008511 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 315730008512 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 315730008513 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008515 putative substrate translocation pore; other site 315730008516 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 315730008517 Predicted membrane protein [Function unknown]; Region: COG2261 315730008518 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730008519 active site 315730008520 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 315730008521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008522 S-adenosylmethionine binding site [chemical binding]; other site 315730008523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008524 putative substrate translocation pore; other site 315730008525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008526 aspartate aminotransferase; Provisional; Region: PRK07681 315730008527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008529 homodimer interface [polypeptide binding]; other site 315730008530 catalytic residue [active] 315730008531 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315730008532 pantothenate kinase; Provisional; Region: PRK13317 315730008533 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 315730008534 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730008535 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 315730008536 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 315730008537 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 315730008538 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730008539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730008540 Walker A/P-loop; other site 315730008541 ATP binding site [chemical binding]; other site 315730008542 Q-loop/lid; other site 315730008543 ABC transporter signature motif; other site 315730008544 Walker B; other site 315730008545 D-loop; other site 315730008546 H-loop/switch region; other site 315730008547 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730008548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730008549 DNA-binding site [nucleotide binding]; DNA binding site 315730008550 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008551 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008552 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008553 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008554 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008555 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008556 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 315730008557 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730008558 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730008559 HNH endonuclease; Region: HNH_5; pfam14279 315730008560 Protein of unknown function (DUF402); Region: DUF402; pfam04167 315730008561 Tetratrico peptide repeat; Region: TPR_5; pfam12688 315730008562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730008563 binding surface 315730008564 TPR motif; other site 315730008565 hypothetical protein; Provisional; Region: PRK09620 315730008566 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 315730008567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008568 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730008569 Coenzyme A binding pocket [chemical binding]; other site 315730008570 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 315730008571 DinB superfamily; Region: DinB_2; pfam12867 315730008572 Protein of unknown function (DUF664); Region: DUF664; pfam04978 315730008573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730008574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008575 Coenzyme A binding pocket [chemical binding]; other site 315730008576 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008577 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730008578 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 315730008579 active site 315730008580 NTP binding site [chemical binding]; other site 315730008581 metal binding triad [ion binding]; metal-binding site 315730008582 antibiotic binding site [chemical binding]; other site 315730008583 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 315730008584 A new structural DNA glycosylase; Region: AlkD_like; cd06561 315730008585 active site 315730008586 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 315730008587 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730008588 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730008589 NodB motif; other site 315730008590 active site 315730008591 catalytic site [active] 315730008592 Zn binding site [ion binding]; other site 315730008593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730008595 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008598 putative substrate translocation pore; other site 315730008599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008600 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730008601 Sulfatase; Region: Sulfatase; pfam00884 315730008602 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315730008603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730008605 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730008606 nudix motif; other site 315730008607 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 315730008608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008609 Coenzyme A binding pocket [chemical binding]; other site 315730008610 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 315730008611 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315730008612 hinge; other site 315730008613 active site 315730008614 prephenate dehydrogenase; Validated; Region: PRK06545 315730008615 prephenate dehydrogenase; Validated; Region: PRK08507 315730008616 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 315730008617 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 315730008618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008620 homodimer interface [polypeptide binding]; other site 315730008621 catalytic residue [active] 315730008622 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 315730008623 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315730008624 Tetramer interface [polypeptide binding]; other site 315730008625 active site 315730008626 FMN-binding site [chemical binding]; other site 315730008627 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 315730008628 Chorismate mutase type II; Region: CM_2; cl00693 315730008629 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 315730008630 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 315730008631 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 315730008632 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 315730008633 Isochorismatase family; Region: Isochorismatase; pfam00857 315730008634 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730008635 catalytic triad [active] 315730008636 conserved cis-peptide bond; other site 315730008637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008639 Coenzyme A binding pocket [chemical binding]; other site 315730008640 seryl-tRNA synthetase; Provisional; Region: PRK05431 315730008641 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730008642 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 315730008643 dimer interface [polypeptide binding]; other site 315730008644 active site 315730008645 motif 1; other site 315730008646 motif 2; other site 315730008647 motif 3; other site 315730008648 hypothetical protein; Provisional; Region: PRK06762 315730008649 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730008650 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730008651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315730008652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 315730008653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008654 putative metal binding site [ion binding]; other site 315730008655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008657 Coenzyme A binding pocket [chemical binding]; other site 315730008658 Predicted flavoprotein [General function prediction only]; Region: COG0431 315730008659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730008660 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730008661 DinB superfamily; Region: DinB_2; pfam12867 315730008662 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 315730008663 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 315730008664 malate:quinone oxidoreductase; Validated; Region: PRK05257 315730008665 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 315730008666 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730008667 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730008668 TM-ABC transporter signature motif; other site 315730008669 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730008670 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315730008671 Walker A/P-loop; other site 315730008672 ATP binding site [chemical binding]; other site 315730008673 Q-loop/lid; other site 315730008674 ABC transporter signature motif; other site 315730008675 Walker B; other site 315730008676 D-loop; other site 315730008677 H-loop/switch region; other site 315730008678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315730008679 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730008680 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730008681 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 315730008682 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 315730008683 putative N- and C-terminal domain interface [polypeptide binding]; other site 315730008684 putative active site [active] 315730008685 putative MgATP binding site [chemical binding]; other site 315730008686 catalytic site [active] 315730008687 metal binding site [ion binding]; metal-binding site 315730008688 putative carbohydrate binding site [chemical binding]; other site 315730008689 Cupin domain; Region: Cupin_2; pfam07883 315730008690 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 315730008691 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 315730008692 putative active site; other site 315730008693 catalytic residue [active] 315730008694 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730008695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008696 S-adenosylmethionine binding site [chemical binding]; other site 315730008697 Chorismate mutase type II; Region: CM_2; smart00830 315730008698 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 315730008699 active site 315730008700 NTP binding site [chemical binding]; other site 315730008701 metal binding triad [ion binding]; metal-binding site 315730008702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008703 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730008704 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 315730008705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008706 dimerization interface [polypeptide binding]; other site 315730008707 putative DNA binding site [nucleotide binding]; other site 315730008708 putative Zn2+ binding site [ion binding]; other site 315730008709 DinB superfamily; Region: DinB_2; pfam12867 315730008710 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 315730008711 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 315730008712 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 315730008713 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 315730008714 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 315730008715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730008716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730008717 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730008718 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730008719 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730008720 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315730008721 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315730008722 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315730008723 putative catalytic cysteine [active] 315730008724 gamma-glutamyl kinase; Provisional; Region: PRK05429 315730008725 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315730008726 nucleotide binding site [chemical binding]; other site 315730008727 homotetrameric interface [polypeptide binding]; other site 315730008728 putative phosphate binding site [ion binding]; other site 315730008729 putative allosteric binding site; other site 315730008730 PUA domain; Region: PUA; pfam01472 315730008731 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 315730008732 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 315730008733 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 315730008734 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 315730008735 putative di-iron ligands [ion binding]; other site 315730008736 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315730008737 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315730008738 active site 315730008739 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730008740 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 315730008741 Walker A/P-loop; other site 315730008742 ATP binding site [chemical binding]; other site 315730008743 Q-loop/lid; other site 315730008744 Walker B; other site 315730008745 D-loop; other site 315730008746 H-loop/switch region; other site 315730008747 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730008748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008749 motif II; other site 315730008750 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315730008751 active site 315730008752 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315730008753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315730008754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 315730008755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315730008756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730008757 dimer interface [polypeptide binding]; other site 315730008758 conserved gate region; other site 315730008759 putative PBP binding loops; other site 315730008760 ABC-ATPase subunit interface; other site 315730008761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730008762 dimer interface [polypeptide binding]; other site 315730008763 conserved gate region; other site 315730008764 putative PBP binding loops; other site 315730008765 ABC-ATPase subunit interface; other site 315730008766 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730008767 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 315730008768 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315730008769 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 315730008770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730008771 salt bridge; other site 315730008772 non-specific DNA binding site [nucleotide binding]; other site 315730008773 sequence-specific DNA binding site [nucleotide binding]; other site 315730008774 uridine kinase; Provisional; Region: PRK07667 315730008775 active site 315730008776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008777 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730008778 Coenzyme A binding pocket [chemical binding]; other site 315730008779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008780 active site 315730008781 metal binding site [ion binding]; metal-binding site 315730008782 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 315730008783 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730008784 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 315730008785 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730008786 Transcriptional regulator PadR-like family; Region: PadR; cl17335 315730008787 MoxR-like ATPases [General function prediction only]; Region: COG0714 315730008788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730008789 Walker A motif; other site 315730008790 ATP binding site [chemical binding]; other site 315730008791 Walker B motif; other site 315730008792 arginine finger; other site 315730008793 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315730008794 Protein of unknown function DUF58; Region: DUF58; pfam01882 315730008795 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 315730008796 proline/glycine betaine transporter; Provisional; Region: PRK10642 315730008797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008798 putative substrate translocation pore; other site 315730008799 acetylornithine aminotransferase; Provisional; Region: PRK02627 315730008800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730008801 inhibitor-cofactor binding pocket; inhibition site 315730008802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008803 catalytic residue [active] 315730008804 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 315730008805 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315730008806 heme binding pocket [chemical binding]; other site 315730008807 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730008808 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730008809 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730008810 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 315730008811 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730008812 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315730008813 active site 315730008814 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 315730008815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730008816 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730008817 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 315730008818 Uncharacterized conserved protein [Function unknown]; Region: COG1359 315730008819 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315730008820 dimer interface [polypeptide binding]; other site 315730008821 FMN binding site [chemical binding]; other site 315730008822 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730008823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008824 putative DNA binding site [nucleotide binding]; other site 315730008825 putative Zn2+ binding site [ion binding]; other site 315730008826 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 315730008827 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 315730008828 G1 box; other site 315730008829 putative GEF interaction site [polypeptide binding]; other site 315730008830 GTP/Mg2+ binding site [chemical binding]; other site 315730008831 Switch I region; other site 315730008832 G2 box; other site 315730008833 G3 box; other site 315730008834 Switch II region; other site 315730008835 G4 box; other site 315730008836 G5 box; other site 315730008837 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 315730008838 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 315730008839 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 315730008840 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730008841 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 315730008842 nudix motif; other site 315730008843 WGR domain; Region: WGR; cl01581 315730008844 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 315730008845 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730008846 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 315730008847 putative NAD(P) binding site [chemical binding]; other site 315730008848 active site 315730008849 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730008850 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730008851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730008852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730008853 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730008854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730008855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008856 Coenzyme A binding pocket [chemical binding]; other site 315730008857 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 315730008858 EamA-like transporter family; Region: EamA; pfam00892 315730008859 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730008860 EamA-like transporter family; Region: EamA; pfam00892 315730008861 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730008862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730008863 DNA-binding site [nucleotide binding]; DNA binding site 315730008864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008866 homodimer interface [polypeptide binding]; other site 315730008867 catalytic residue [active] 315730008868 hypothetical protein; Validated; Region: PRK00124 315730008869 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 315730008870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730008871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008873 ATP binding site [chemical binding]; other site 315730008874 Mg2+ binding site [ion binding]; other site 315730008875 G-X-G motif; other site 315730008876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008878 active site 315730008879 phosphorylation site [posttranslational modification] 315730008880 intermolecular recognition site; other site 315730008881 dimerization interface [polypeptide binding]; other site 315730008882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008883 DNA binding site [nucleotide binding] 315730008884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730008885 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 315730008886 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 315730008887 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315730008888 uridine kinase; Validated; Region: PRK06696 315730008889 AAA domain; Region: AAA_18; pfam13238 315730008890 active site 315730008891 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 315730008892 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730008893 active site 315730008894 metal binding site [ion binding]; metal-binding site 315730008895 Phosphotransferase enzyme family; Region: APH; pfam01636 315730008896 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315730008897 active site 315730008898 ATP binding site [chemical binding]; other site 315730008899 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 315730008900 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730008901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008903 Coenzyme A binding pocket [chemical binding]; other site 315730008904 lysine transporter; Provisional; Region: PRK10836 315730008905 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315730008906 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 315730008907 Methyltransferase domain; Region: Methyltransf_11; pfam08241 315730008908 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730008909 putative active site [active] 315730008910 nucleotide binding site [chemical binding]; other site 315730008911 nudix motif; other site 315730008912 putative metal binding site [ion binding]; other site 315730008913 Cephalosporin hydroxylase; Region: CmcI; pfam04989 315730008914 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730008915 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730008916 Catalytic site [active] 315730008917 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730008918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008919 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730008921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730008922 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730008923 Probable transposase; Region: OrfB_IS605; pfam01385 315730008924 NAD-dependent deacetylase; Provisional; Region: PRK00481 315730008925 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 315730008926 NAD+ binding site [chemical binding]; other site 315730008927 substrate binding site [chemical binding]; other site 315730008928 Zn binding site [ion binding]; other site 315730008929 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730008930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008931 putative substrate translocation pore; other site 315730008932 POT family; Region: PTR2; cl17359 315730008933 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 315730008934 putative substrate binding pocket [chemical binding]; other site 315730008935 AC domain interface; other site 315730008936 catalytic triad [active] 315730008937 AB domain interface; other site 315730008938 interchain disulfide; other site 315730008939 Predicted membrane protein [Function unknown]; Region: COG3817 315730008940 Protein of unknown function (DUF979); Region: DUF979; pfam06166 315730008941 Protein of unknown function (DUF969); Region: DUF969; pfam06149 315730008942 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 315730008943 putative active site [active] 315730008944 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 315730008945 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 315730008946 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 315730008947 Transcriptional regulator [Transcription]; Region: IclR; COG1414 315730008948 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 315730008949 Bacterial transcriptional regulator; Region: IclR; pfam01614 315730008950 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315730008951 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730008952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730008953 Catalytic site [active] 315730008954 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 315730008955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730008956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730008957 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 315730008958 Uncharacterized conserved protein [Function unknown]; Region: COG1434 315730008959 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730008960 putative active site [active] 315730008961 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730008962 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730008963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730008965 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 315730008966 putative hydrophobic ligand binding site [chemical binding]; other site 315730008967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008968 dimerization interface [polypeptide binding]; other site 315730008969 putative DNA binding site [nucleotide binding]; other site 315730008970 putative Zn2+ binding site [ion binding]; other site 315730008971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 315730008972 Nucleoside recognition; Region: Gate; pfam07670 315730008973 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 315730008974 Phosphotransferase enzyme family; Region: APH; pfam01636 315730008975 putative active site [active] 315730008976 putative substrate binding site [chemical binding]; other site 315730008977 ATP binding site [chemical binding]; other site 315730008978 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 315730008979 Uncharacterized conserved protein [Function unknown]; Region: COG1633 315730008980 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 315730008981 dinuclear metal binding motif [ion binding]; other site 315730008982 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730008983 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 315730008984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730008986 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730008987 phosphoenolpyruvate synthase; Validated; Region: PRK06241 315730008988 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 315730008989 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 315730008990 YolD-like protein; Region: YolD; pfam08863 315730008991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730008992 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730008993 Probable transposase; Region: OrfB_IS605; pfam01385 315730008994 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730008995 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315730008996 putative active site [active] 315730008997 putative metal binding site [ion binding]; other site 315730008998 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730008999 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 315730009000 Cl binding site [ion binding]; other site 315730009001 oligomer interface [polypeptide binding]; other site 315730009002 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 315730009003 plasmid segregation protein ParM; Provisional; Region: PRK13917 315730009004 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 315730009005 Mg binding site [ion binding]; other site 315730009006 nucleotide binding site [chemical binding]; other site 315730009007 putative protofilament interface [polypeptide binding]; other site 315730009008 Heat induced stress protein YflT; Region: YflT; pfam11181 315730009009 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730009010 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 315730009011 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730009012 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730009013 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730009014 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730009015 NodB motif; other site 315730009016 active site 315730009017 catalytic site [active] 315730009018 Zn binding site [ion binding]; other site 315730009019 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730009020 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730009021 active site 315730009022 metal binding site [ion binding]; metal-binding site 315730009023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730009024 dimerization interface [polypeptide binding]; other site 315730009025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009026 dimer interface [polypeptide binding]; other site 315730009027 phosphorylation site [posttranslational modification] 315730009028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009029 ATP binding site [chemical binding]; other site 315730009030 Mg2+ binding site [ion binding]; other site 315730009031 G-X-G motif; other site 315730009032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009034 active site 315730009035 phosphorylation site [posttranslational modification] 315730009036 intermolecular recognition site; other site 315730009037 dimerization interface [polypeptide binding]; other site 315730009038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009039 DNA binding site [nucleotide binding] 315730009040 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 315730009041 UbiA prenyltransferase family; Region: UbiA; pfam01040 315730009042 DJ-1 family protein; Region: not_thiJ; TIGR01383 315730009043 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 315730009044 conserved cys residue [active] 315730009045 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 315730009046 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730009047 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315730009048 active site 315730009049 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 315730009050 arsenical-resistance protein; Region: acr3; TIGR00832 315730009051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 315730009053 putative metal binding site [ion binding]; other site 315730009054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730009055 dimerization interface [polypeptide binding]; other site 315730009056 putative DNA binding site [nucleotide binding]; other site 315730009057 putative Zn2+ binding site [ion binding]; other site 315730009058 DinB superfamily; Region: DinB_2; pfam12867 315730009059 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 315730009060 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 315730009061 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 315730009062 putative NAD(P) binding site [chemical binding]; other site 315730009063 active site 315730009064 putative substrate binding site [chemical binding]; other site 315730009065 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730009066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730009067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730009068 short chain dehydrogenase; Provisional; Region: PRK12746 315730009069 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 315730009070 NADP binding site [chemical binding]; other site 315730009071 homodimer interface [polypeptide binding]; other site 315730009072 active site 315730009073 substrate binding site [chemical binding]; other site 315730009074 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315730009075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730009076 putative DNA binding site [nucleotide binding]; other site 315730009077 putative Zn2+ binding site [ion binding]; other site 315730009078 AsnC family; Region: AsnC_trans_reg; pfam01037 315730009079 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 315730009080 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730009081 metal binding site [ion binding]; metal-binding site 315730009082 AAA domain; Region: AAA_11; pfam13086 315730009083 Part of AAA domain; Region: AAA_19; pfam13245 315730009084 Erp protein C-terminus; Region: Erp_C; pfam06780 315730009085 AAA domain; Region: AAA_30; pfam13604 315730009086 AAA domain; Region: AAA_12; pfam13087 315730009087 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 315730009088 putative active site [active] 315730009089 catalytic site [active] 315730009090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009091 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730009092 active site 315730009093 metal binding site [ion binding]; metal-binding site 315730009094 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 315730009095 putative monooxygenase; Provisional; Region: PRK11118 315730009096 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730009097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009098 S-adenosylmethionine binding site [chemical binding]; other site 315730009099 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 315730009100 Cytochrome P450; Region: p450; pfam00067 315730009101 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 315730009102 Flavodoxin; Region: Flavodoxin_1; pfam00258 315730009103 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 315730009104 FAD binding pocket [chemical binding]; other site 315730009105 FAD binding motif [chemical binding]; other site 315730009106 catalytic residues [active] 315730009107 NAD binding pocket [chemical binding]; other site 315730009108 phosphate binding motif [ion binding]; other site 315730009109 beta-alpha-beta structure motif; other site 315730009110 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730009111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009112 putative substrate translocation pore; other site 315730009113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009114 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 315730009115 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 315730009116 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315730009117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009119 active site 315730009120 phosphorylation site [posttranslational modification] 315730009121 intermolecular recognition site; other site 315730009122 dimerization interface [polypeptide binding]; other site 315730009123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009124 DNA binding site [nucleotide binding] 315730009125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730009126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730009127 dimerization interface [polypeptide binding]; other site 315730009128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009129 dimer interface [polypeptide binding]; other site 315730009130 phosphorylation site [posttranslational modification] 315730009131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009132 ATP binding site [chemical binding]; other site 315730009133 G-X-G motif; other site 315730009134 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 315730009135 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315730009136 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730009137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009138 S-adenosylmethionine binding site [chemical binding]; other site 315730009139 D-cysteine desulfhydrase; Validated; Region: PRK03910 315730009140 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 315730009141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730009142 catalytic residue [active] 315730009143 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730009144 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315730009145 active site 315730009146 metal binding site [ion binding]; metal-binding site 315730009147 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 315730009148 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009149 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009150 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 315730009151 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 315730009152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 315730009153 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730009154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009155 NAD(P) binding site [chemical binding]; other site 315730009156 active site 315730009157 hypothetical protein; Provisional; Region: PRK06849 315730009158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009159 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 315730009160 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 315730009161 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315730009162 dimer interface [polypeptide binding]; other site 315730009163 active site 315730009164 CoA binding pocket [chemical binding]; other site 315730009165 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 315730009166 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 315730009167 CAAX protease self-immunity; Region: Abi; pfam02517 315730009168 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315730009169 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009170 DNA binding residues [nucleotide binding] 315730009171 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 315730009172 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 315730009173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730009174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730009175 Walker A/P-loop; other site 315730009176 ATP binding site [chemical binding]; other site 315730009177 Q-loop/lid; other site 315730009178 ABC transporter signature motif; other site 315730009179 Walker B; other site 315730009180 D-loop; other site 315730009181 H-loop/switch region; other site 315730009182 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730009183 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730009184 FtsX-like permease family; Region: FtsX; pfam02687 315730009185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730009186 dimerization interface [polypeptide binding]; other site 315730009187 putative DNA binding site [nucleotide binding]; other site 315730009188 putative Zn2+ binding site [ion binding]; other site 315730009189 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730009190 DinB superfamily; Region: DinB_2; pfam12867 315730009191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730009192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730009193 dimerization interface [polypeptide binding]; other site 315730009194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009195 dimer interface [polypeptide binding]; other site 315730009196 phosphorylation site [posttranslational modification] 315730009197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009198 ATP binding site [chemical binding]; other site 315730009199 Mg2+ binding site [ion binding]; other site 315730009200 G-X-G motif; other site 315730009201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009203 active site 315730009204 phosphorylation site [posttranslational modification] 315730009205 intermolecular recognition site; other site 315730009206 dimerization interface [polypeptide binding]; other site 315730009207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009208 DNA binding site [nucleotide binding] 315730009209 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730009210 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730009211 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730009212 2TM domain; Region: 2TM; pfam13239 315730009213 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 315730009214 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315730009215 putative dimer interface [polypeptide binding]; other site 315730009216 catalytic triad [active] 315730009217 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 315730009218 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 315730009219 dimer interaction site [polypeptide binding]; other site 315730009220 substrate-binding tunnel; other site 315730009221 active site 315730009222 catalytic site [active] 315730009223 substrate binding site [chemical binding]; other site 315730009224 Uncharacterized conserved protein [Function unknown]; Region: COG4198 315730009225 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 315730009226 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 315730009227 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 315730009228 putative ligand binding site [chemical binding]; other site 315730009229 putative NAD binding site [chemical binding]; other site 315730009230 putative catalytic site [active] 315730009231 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 315730009232 L-serine binding site [chemical binding]; other site 315730009233 ACT domain interface; other site 315730009234 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 315730009235 homodimer interface [polypeptide binding]; other site 315730009236 substrate-cofactor binding pocket; other site 315730009237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730009238 catalytic residue [active] 315730009239 Domain of unknown function (DUF378); Region: DUF378; cl00943 315730009240 ADP-ribosyltransferase; Provisional; Region: alt; PHA02566 315730009241 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730009242 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730009243 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 315730009244 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730009245 CAAX protease self-immunity; Region: Abi; pfam02517 315730009246 Erythromycin esterase; Region: Erythro_esteras; pfam05139 315730009247 Putative sensor; Region: Sensor; pfam13796 315730009248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730009249 Histidine kinase; Region: HisKA_3; pfam07730 315730009250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009251 ATP binding site [chemical binding]; other site 315730009252 Mg2+ binding site [ion binding]; other site 315730009253 G-X-G motif; other site 315730009254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730009255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009256 active site 315730009257 phosphorylation site [posttranslational modification] 315730009258 intermolecular recognition site; other site 315730009259 dimerization interface [polypeptide binding]; other site 315730009260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730009261 DNA binding residues [nucleotide binding] 315730009262 dimerization interface [polypeptide binding]; other site 315730009263 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 315730009264 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 315730009265 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 315730009266 active site 315730009267 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 315730009268 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315730009269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730009270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730009271 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730009272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009273 putative substrate translocation pore; other site 315730009274 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 315730009275 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315730009276 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730009277 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315730009278 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315730009279 putative active site [active] 315730009280 putative metal binding site [ion binding]; other site 315730009281 NETI protein; Region: NETI; pfam14044 315730009282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009284 putative substrate translocation pore; other site 315730009285 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730009286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315730009287 TAP-like protein; Region: Abhydrolase_4; pfam08386 315730009288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730009289 MarR family; Region: MarR_2; pfam12802 315730009290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009292 putative substrate translocation pore; other site 315730009293 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009294 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009295 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 315730009296 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315730009297 DNA binding residues [nucleotide binding] 315730009298 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730009299 dimer interface [polypeptide binding]; other site 315730009300 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730009301 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009302 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009303 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009304 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009305 hypothetical protein; Provisional; Region: PRK06770 315730009306 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730009307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730009308 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 315730009309 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730009310 active site 315730009311 ATP binding site [chemical binding]; other site 315730009312 substrate binding site [chemical binding]; other site 315730009313 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 315730009314 putative metal binding site [ion binding]; other site 315730009315 putative dimer interface [polypeptide binding]; other site 315730009316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 315730009317 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730009318 active site 315730009319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 315730009320 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 315730009321 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 315730009322 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 315730009323 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730009324 SWIM zinc finger; Region: SWIM; pfam04434 315730009325 YwiC-like protein; Region: YwiC; pfam14256 315730009326 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 315730009327 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730009328 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 315730009329 Walker A/P-loop; other site 315730009330 ATP binding site [chemical binding]; other site 315730009331 Q-loop/lid; other site 315730009332 ABC transporter signature motif; other site 315730009333 Walker B; other site 315730009334 D-loop; other site 315730009335 H-loop/switch region; other site 315730009336 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730009337 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 315730009338 Walker A/P-loop; other site 315730009339 ATP binding site [chemical binding]; other site 315730009340 Q-loop/lid; other site 315730009341 ABC transporter signature motif; other site 315730009342 Walker B; other site 315730009343 D-loop; other site 315730009344 H-loop/switch region; other site 315730009345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730009346 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730009347 Probable transposase; Region: OrfB_IS605; pfam01385 315730009348 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 315730009349 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 315730009350 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 315730009351 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 315730009352 Predicted membrane protein [Function unknown]; Region: COG1288 315730009353 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 315730009354 Endonuclease I; Region: Endonuclease_1; pfam04231 315730009355 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 315730009356 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 315730009357 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730009358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730009359 non-specific DNA binding site [nucleotide binding]; other site 315730009360 salt bridge; other site 315730009361 sequence-specific DNA binding site [nucleotide binding]; other site 315730009362 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 315730009363 putative deacylase active site [active] 315730009364 histidyl-tRNA synthetase; Provisional; Region: PRK12420 315730009365 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 315730009366 dimer interface [polypeptide binding]; other site 315730009367 motif 1; other site 315730009368 active site 315730009369 motif 2; other site 315730009370 motif 3; other site 315730009371 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315730009372 anticodon binding site; other site 315730009373 pyruvate kinase; Validated; Region: PRK06739 315730009374 active site 315730009375 domain interfaces; other site 315730009376 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315730009377 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315730009378 dimer interface [polypeptide binding]; other site 315730009379 active site 315730009380 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315730009381 dimer interface [polypeptide binding]; other site 315730009382 FMN binding site [chemical binding]; other site 315730009383 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730009384 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315730009385 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 315730009386 classical (c) SDRs; Region: SDR_c; cd05233 315730009387 NAD(P) binding site [chemical binding]; other site 315730009388 active site 315730009389 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730009390 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730009391 Walker A/P-loop; other site 315730009392 ATP binding site [chemical binding]; other site 315730009393 Q-loop/lid; other site 315730009394 ABC transporter signature motif; other site 315730009395 Walker B; other site 315730009396 D-loop; other site 315730009397 H-loop/switch region; other site 315730009398 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 315730009399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730009400 non-specific DNA binding site [nucleotide binding]; other site 315730009401 salt bridge; other site 315730009402 sequence-specific DNA binding site [nucleotide binding]; other site 315730009403 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730009404 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730009405 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 315730009406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009407 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 315730009408 DinB superfamily; Region: DinB_2; pfam12867 315730009409 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 315730009410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730009411 motif II; other site 315730009412 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 315730009413 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 315730009414 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730009415 Coenzyme A binding pocket [chemical binding]; other site 315730009416 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 315730009417 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730009418 nudix motif; other site 315730009419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 315730009420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009421 putative metal binding site [ion binding]; other site 315730009422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315730009423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 315730009424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009426 putative substrate translocation pore; other site 315730009427 maltose O-acetyltransferase; Provisional; Region: PRK10092 315730009428 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 315730009429 active site 315730009430 substrate binding site [chemical binding]; other site 315730009431 trimer interface [polypeptide binding]; other site 315730009432 CoA binding site [chemical binding]; other site 315730009433 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315730009434 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315730009435 active site 315730009436 HIGH motif; other site 315730009437 dimer interface [polypeptide binding]; other site 315730009438 KMSKS motif; other site 315730009439 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 315730009440 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315730009441 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315730009442 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315730009443 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730009444 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730009445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730009446 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730009447 Coenzyme A binding pocket [chemical binding]; other site 315730009448 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 315730009449 homodimer interaction site [polypeptide binding]; other site 315730009450 cofactor binding site; other site 315730009451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730009452 binding surface 315730009453 TPR repeat; Region: TPR_11; pfam13414 315730009454 TPR motif; other site 315730009455 TPR repeat; Region: TPR_11; pfam13414 315730009456 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 315730009457 hypothetical protein; Provisional; Region: PRK04164 315730009458 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730009459 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730009460 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730009461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730009462 Transporter associated domain; Region: CorC_HlyC; smart01091 315730009463 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 315730009464 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730009465 DNA binding residues [nucleotide binding] 315730009466 putative dimer interface [polypeptide binding]; other site 315730009467 EamA-like transporter family; Region: EamA; pfam00892 315730009468 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730009469 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 315730009470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730009471 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730009472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 315730009473 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 315730009474 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730009475 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315730009476 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315730009477 N- and C-terminal domain interface [polypeptide binding]; other site 315730009478 active site 315730009479 catalytic site [active] 315730009480 metal binding site [ion binding]; metal-binding site 315730009481 carbohydrate binding site [chemical binding]; other site 315730009482 ATP binding site [chemical binding]; other site 315730009483 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315730009484 active site 315730009485 intersubunit interactions; other site 315730009486 catalytic residue [active] 315730009487 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 315730009488 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315730009489 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 315730009490 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 315730009491 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 315730009492 hypothetical protein; Provisional; Region: PRK02487 315730009493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730009494 Phosphotransferase enzyme family; Region: APH; pfam01636 315730009495 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 315730009496 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315730009497 nudix motif; other site 315730009498 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 315730009499 Uncharacterized conserved protein [Function unknown]; Region: COG0327 315730009500 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 315730009501 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 315730009502 short chain dehydrogenase; Provisional; Region: PRK12828 315730009503 NADP binding site [chemical binding]; other site 315730009504 homodimer interface [polypeptide binding]; other site 315730009505 active site 315730009506 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730009507 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730009508 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 315730009509 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730009510 acyl-activating enzyme (AAE) consensus motif; other site 315730009511 AMP binding site [chemical binding]; other site 315730009512 active site 315730009513 CoA binding site [chemical binding]; other site 315730009514 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 315730009515 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730009516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730009517 dimerization interface [polypeptide binding]; other site 315730009518 putative DNA binding site [nucleotide binding]; other site 315730009519 putative Zn2+ binding site [ion binding]; other site 315730009520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730009521 dimerization interface [polypeptide binding]; other site 315730009522 putative DNA binding site [nucleotide binding]; other site 315730009523 putative Zn2+ binding site [ion binding]; other site 315730009524 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 315730009525 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 315730009526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009527 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730009528 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730009529 catalytic residues [active] 315730009530 catalytic nucleophile [active] 315730009531 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730009532 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730009533 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730009534 Synaptic Site I dimer interface [polypeptide binding]; other site 315730009535 DNA binding site [nucleotide binding] 315730009536 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 315730009537 DNA-binding interface [nucleotide binding]; DNA binding site 315730009538 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730009539 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315730009540 TQXA domain; Region: TQXA_dom; TIGR03934 315730009541 Cna protein B-type domain; Region: Cna_B; pfam05738 315730009542 Cna protein B-type domain; Region: Cna_B; pfam05738 315730009543 Cna protein B-type domain; Region: Cna_B; pfam05738 315730009544 Cna protein B-type domain; Region: Cna_B; pfam05738 315730009545 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 315730009546 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315730009547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009548 dimer interface [polypeptide binding]; other site 315730009549 phosphorylation site [posttranslational modification] 315730009550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009551 ATP binding site [chemical binding]; other site 315730009552 Mg2+ binding site [ion binding]; other site 315730009553 G-X-G motif; other site 315730009554 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 315730009555 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730009556 catalytic residue [active] 315730009557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 315730009558 nudix motif; other site 315730009559 Putative zinc-finger; Region: zf-HC2; pfam13490 315730009560 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730009561 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 315730009562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730009564 DNA binding residues [nucleotide binding] 315730009565 CAAX protease self-immunity; Region: Abi; pfam02517 315730009566 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730009567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730009568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730009569 dimerization interface [polypeptide binding]; other site 315730009570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009571 dimer interface [polypeptide binding]; other site 315730009572 phosphorylation site [posttranslational modification] 315730009573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009574 ATP binding site [chemical binding]; other site 315730009575 Mg2+ binding site [ion binding]; other site 315730009576 G-X-G motif; other site 315730009577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009579 active site 315730009580 phosphorylation site [posttranslational modification] 315730009581 intermolecular recognition site; other site 315730009582 dimerization interface [polypeptide binding]; other site 315730009583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009584 DNA binding site [nucleotide binding] 315730009585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730009587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730009588 dimerization interface [polypeptide binding]; other site 315730009589 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730009590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009591 NAD(P) binding site [chemical binding]; other site 315730009592 active site 315730009593 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 315730009594 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730009595 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730009596 HTH domain; Region: HTH_11; pfam08279 315730009597 WYL domain; Region: WYL; pfam13280 315730009598 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 315730009599 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 315730009600 ABC-2 type transporter; Region: ABC2_membrane; cl17235 315730009601 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730009602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730009603 Walker A/P-loop; other site 315730009604 ATP binding site [chemical binding]; other site 315730009605 Q-loop/lid; other site 315730009606 ABC transporter signature motif; other site 315730009607 Walker B; other site 315730009608 D-loop; other site 315730009609 H-loop/switch region; other site 315730009610 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 315730009611 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730009612 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730009613 hydroxylamine reductase; Provisional; Region: PRK12310 315730009614 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730009615 ACS interaction site; other site 315730009616 CODH interaction site; other site 315730009617 metal cluster binding site [ion binding]; other site 315730009618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730009619 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 315730009620 metal binding site [ion binding]; metal-binding site 315730009621 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 315730009622 hypothetical protein; Provisional; Region: PRK06771 315730009623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009624 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009625 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 315730009626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 315730009627 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 315730009628 dimer interface [polypeptide binding]; other site 315730009629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009630 ligand binding site [chemical binding]; other site 315730009631 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730009632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730009633 ligand binding site [chemical binding]; other site 315730009634 flexible hinge region; other site 315730009635 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 315730009636 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315730009637 Protein of unknown function, DUF606; Region: DUF606; pfam04657 315730009638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730009639 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 315730009640 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 315730009641 putative NAD(P) binding site [chemical binding]; other site 315730009642 dimer interface [polypeptide binding]; other site 315730009643 putative transport protein YifK; Provisional; Region: PRK10746 315730009644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009645 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315730009646 putative substrate translocation pore; other site 315730009647 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730009648 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730009649 active site 315730009650 aminotransferase; Validated; Region: PRK07678 315730009651 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730009652 inhibitor-cofactor binding pocket; inhibition site 315730009653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730009654 catalytic residue [active] 315730009655 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315730009656 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 315730009657 tetrameric interface [polypeptide binding]; other site 315730009658 NAD binding site [chemical binding]; other site 315730009659 catalytic residues [active] 315730009660 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 315730009661 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730009662 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 315730009663 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315730009664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730009665 tetramerization interface [polypeptide binding]; other site 315730009666 NAD(P) binding site [chemical binding]; other site 315730009667 catalytic residues [active] 315730009668 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 315730009669 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730009670 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 315730009671 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009672 DNA binding residues [nucleotide binding] 315730009673 putative dimer interface [polypeptide binding]; other site 315730009674 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 315730009675 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 315730009676 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 315730009677 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 315730009678 transmembrane helices; other site 315730009679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 315730009680 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730009681 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730009682 Coenzyme A binding pocket [chemical binding]; other site 315730009683 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730009684 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730009685 putative ligand binding residues [chemical binding]; other site 315730009686 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730009687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009688 ABC-ATPase subunit interface; other site 315730009689 dimer interface [polypeptide binding]; other site 315730009690 putative PBP binding regions; other site 315730009691 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730009692 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009693 ABC-ATPase subunit interface; other site 315730009694 dimer interface [polypeptide binding]; other site 315730009695 putative PBP binding regions; other site 315730009696 Protein of unknown function (DUF817); Region: DUF817; pfam05675 315730009697 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 315730009698 DinB superfamily; Region: DinB_2; pfam12867 315730009699 DinB family; Region: DinB; cl17821 315730009700 DinB superfamily; Region: DinB_2; pfam12867 315730009701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730009703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730009704 dimerization interface [polypeptide binding]; other site 315730009705 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730009706 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 315730009707 NADP binding site [chemical binding]; other site 315730009708 dimer interface [polypeptide binding]; other site 315730009709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730009710 catalytic core [active] 315730009711 Predicted acetyltransferase [General function prediction only]; Region: COG3153 315730009712 Coenzyme A binding pocket [chemical binding]; other site 315730009713 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 315730009714 MutS domain III; Region: MutS_III; pfam05192 315730009715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730009716 Walker A/P-loop; other site 315730009717 ATP binding site [chemical binding]; other site 315730009718 Q-loop/lid; other site 315730009719 ABC transporter signature motif; other site 315730009720 Walker B; other site 315730009721 D-loop; other site 315730009722 H-loop/switch region; other site 315730009723 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 315730009724 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 315730009725 active site 315730009726 Na/Ca binding site [ion binding]; other site 315730009727 catalytic site [active] 315730009728 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 315730009729 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 315730009730 oligoendopeptidase F; Region: pepF; TIGR00181 315730009731 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315730009732 active site 315730009733 Zn binding site [ion binding]; other site 315730009734 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 315730009735 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 315730009736 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730009737 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730009738 active site 315730009739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730009740 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315730009741 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009742 DNA binding residues [nucleotide binding] 315730009743 drug binding residues [chemical binding]; other site 315730009744 dimer interface [polypeptide binding]; other site 315730009745 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 315730009746 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 315730009747 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 315730009748 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 315730009749 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 315730009750 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 315730009751 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730009752 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730009753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009754 putative substrate translocation pore; other site 315730009755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730009758 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 315730009759 putative dimerization interface [polypeptide binding]; other site 315730009760 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 315730009761 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 315730009762 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 315730009763 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730009764 FAD binding domain; Region: FAD_binding_3; pfam01494 315730009765 hypothetical protein; Provisional; Region: PRK07236 315730009766 hypothetical protein; Validated; Region: PRK00029 315730009767 Uncharacterized conserved protein [Function unknown]; Region: COG0397 315730009768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730009769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730009770 TPR motif; other site 315730009771 binding surface 315730009772 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 315730009773 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315730009774 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 315730009775 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730009776 FAD binding domain; Region: FAD_binding_4; pfam01565 315730009777 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 315730009778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730009779 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730009780 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730009781 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730009782 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 315730009783 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730009784 MgtC family; Region: MgtC; pfam02308 315730009785 Predicted acetyltransferase [General function prediction only]; Region: COG3981 315730009786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730009787 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730009788 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315730009789 putative metal binding site [ion binding]; other site 315730009790 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730009791 active site 315730009792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730009793 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730009794 substrate binding pocket [chemical binding]; other site 315730009795 membrane-bound complex binding site; other site 315730009796 hinge residues; other site 315730009797 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730009798 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315730009799 Walker A/P-loop; other site 315730009800 ATP binding site [chemical binding]; other site 315730009801 Q-loop/lid; other site 315730009802 ABC transporter signature motif; other site 315730009803 Walker B; other site 315730009804 D-loop; other site 315730009805 H-loop/switch region; other site 315730009806 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730009807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730009808 dimer interface [polypeptide binding]; other site 315730009809 conserved gate region; other site 315730009810 putative PBP binding loops; other site 315730009811 ABC-ATPase subunit interface; other site 315730009812 VanW like protein; Region: VanW; pfam04294 315730009813 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 315730009814 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 315730009815 exonuclease; Provisional; Region: PRK06722 315730009816 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315730009817 active site 315730009818 catalytic site [active] 315730009819 substrate binding site [chemical binding]; other site 315730009820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730009821 DNA-binding site [nucleotide binding]; DNA binding site 315730009822 RNA-binding motif; other site 315730009823 flavodoxin; Provisional; Region: PRK06703 315730009824 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 315730009825 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730009826 nudix motif; other site 315730009827 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 315730009828 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730009829 trimer interface [polypeptide binding]; other site 315730009830 active site 315730009831 substrate binding site [chemical binding]; other site 315730009832 CoA binding site [chemical binding]; other site 315730009833 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009834 Domain of unknown function DUF11; Region: DUF11; cl17728 315730009835 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009836 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009837 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009838 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009839 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009840 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009841 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009842 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009843 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009844 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009845 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009846 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009847 conserved repeat domain; Region: B_ant_repeat; TIGR01451 315730009848 short chain dehydrogenase; Provisional; Region: PRK06924 315730009849 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 315730009850 NADP binding site [chemical binding]; other site 315730009851 homodimer interface [polypeptide binding]; other site 315730009852 active site 315730009853 Predicted acetyltransferase [General function prediction only]; Region: COG3393 315730009854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730009855 Coenzyme A binding pocket [chemical binding]; other site 315730009856 argininosuccinate lyase; Provisional; Region: PRK06705 315730009857 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315730009858 active sites [active] 315730009859 tetramer interface [polypeptide binding]; other site 315730009860 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730009861 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730009862 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730009863 active site 315730009864 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730009865 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 315730009866 Na binding site [ion binding]; other site 315730009867 Protein of unknown function (DUF997); Region: DUF997; pfam06196 315730009868 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315730009869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730009870 NAD(P) binding site [chemical binding]; other site 315730009871 catalytic residues [active] 315730009872 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315730009873 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315730009874 NAD(P) binding site [chemical binding]; other site 315730009875 homotetramer interface [polypeptide binding]; other site 315730009876 homodimer interface [polypeptide binding]; other site 315730009877 active site 315730009878 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 315730009879 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 315730009880 Divergent PAP2 family; Region: DUF212; pfam02681 315730009881 Predicted permeases [General function prediction only]; Region: RarD; COG2962 315730009882 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 315730009883 Tubulin like; Region: Tubulin_2; pfam13809 315730009884 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315730009885 metal ion-dependent adhesion site (MIDAS); other site 315730009886 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730009887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009888 S-adenosylmethionine binding site [chemical binding]; other site 315730009889 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009890 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009891 peptide binding site [polypeptide binding]; other site 315730009892 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009893 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009894 peptide binding site [polypeptide binding]; other site 315730009895 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009896 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009897 peptide binding site [polypeptide binding]; other site 315730009898 Transcriptional regulator [Transcription]; Region: LytR; COG1316 315730009899 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315730009900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730009902 DNA binding residues [nucleotide binding] 315730009903 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 315730009904 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 315730009905 putative active site [active] 315730009906 putative metal-binding site [ion binding]; other site 315730009907 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315730009908 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730009909 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730009910 Walker A/P-loop; other site 315730009911 ATP binding site [chemical binding]; other site 315730009912 Q-loop/lid; other site 315730009913 ABC transporter signature motif; other site 315730009914 Walker B; other site 315730009915 D-loop; other site 315730009916 H-loop/switch region; other site 315730009917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730009918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730009919 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730009920 HTH domain; Region: HTH_11; pfam08279 315730009921 WYL domain; Region: WYL; pfam13280 315730009922 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730009923 dimer interface [polypeptide binding]; other site 315730009924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009925 putative oxidoreductase; Provisional; Region: PRK11579 315730009926 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315730009927 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 315730009928 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 315730009929 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 315730009930 CAP-like domain; other site 315730009931 active site 315730009932 primary dimer interface [polypeptide binding]; other site 315730009933 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009934 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009935 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009937 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 315730009938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009939 ATP binding site [chemical binding]; other site 315730009940 Mg2+ binding site [ion binding]; other site 315730009941 G-X-G motif; other site 315730009942 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315730009943 anchoring element; other site 315730009944 dimer interface [polypeptide binding]; other site 315730009945 ATP binding site [chemical binding]; other site 315730009946 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315730009947 active site 315730009948 putative metal-binding site [ion binding]; other site 315730009949 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315730009950 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 315730009951 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315730009952 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730009953 protein binding site [polypeptide binding]; other site 315730009954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009956 active site 315730009957 phosphorylation site [posttranslational modification] 315730009958 intermolecular recognition site; other site 315730009959 dimerization interface [polypeptide binding]; other site 315730009960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009961 DNA binding site [nucleotide binding] 315730009962 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 315730009963 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 315730009964 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 315730009965 Class III ribonucleotide reductase; Region: RNR_III; cd01675 315730009966 effector binding site; other site 315730009967 active site 315730009968 Zn binding site [ion binding]; other site 315730009969 glycine loop; other site 315730009970 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 315730009971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 315730009972 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315730009973 active site 315730009974 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 315730009975 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730009976 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730009977 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 315730009978 active site 315730009979 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 315730009980 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315730009981 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 315730009982 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730009983 active site 315730009984 catalytic site [active] 315730009985 substrate binding site [chemical binding]; other site 315730009986 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 315730009987 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730009988 catalytic residues [active] 315730009989 YmzC-like protein; Region: YmzC; pfam14157 315730009990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730009991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730009992 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 315730009993 Walker A/P-loop; other site 315730009994 ATP binding site [chemical binding]; other site 315730009995 Q-loop/lid; other site 315730009996 ABC transporter signature motif; other site 315730009997 Walker B; other site 315730009998 D-loop; other site 315730009999 H-loop/switch region; other site 315730010000 aconitate hydratase; Validated; Region: PRK09277 315730010001 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 315730010002 substrate binding site [chemical binding]; other site 315730010003 ligand binding site [chemical binding]; other site 315730010004 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 315730010005 substrate binding site [chemical binding]; other site 315730010006 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 315730010007 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730010008 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 315730010009 NodB motif; other site 315730010010 active site 315730010011 catalytic site [active] 315730010012 metal binding site [ion binding]; metal-binding site 315730010013 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315730010014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730010015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730010016 putative substrate translocation pore; other site 315730010017 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 315730010018 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315730010019 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730010020 nudix motif; other site 315730010021 SAP domain; Region: SAP; pfam02037 315730010022 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 315730010023 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730010024 dimer interface [polypeptide binding]; other site 315730010025 active site 315730010026 acyl-CoA synthetase; Validated; Region: PRK07638 315730010027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730010028 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730010029 acyl-activating enzyme (AAE) consensus motif; other site 315730010030 AMP binding site [chemical binding]; other site 315730010031 active site 315730010032 CoA binding site [chemical binding]; other site 315730010033 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 315730010034 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315730010035 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 315730010036 dimer interface [polypeptide binding]; other site 315730010037 acyl-activating enzyme (AAE) consensus motif; other site 315730010038 putative active site [active] 315730010039 AMP binding site [chemical binding]; other site 315730010040 putative CoA binding site [chemical binding]; other site 315730010041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730010042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010043 non-specific DNA binding site [nucleotide binding]; other site 315730010044 salt bridge; other site 315730010045 sequence-specific DNA binding site [nucleotide binding]; other site 315730010046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730010047 Coenzyme A binding pocket [chemical binding]; other site 315730010048 S-layer homology domain; Region: SLH; pfam00395 315730010049 S-layer homology domain; Region: SLH; pfam00395 315730010050 S-layer homology domain; Region: SLH; pfam00395 315730010051 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 315730010052 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730010053 amidase catalytic site [active] 315730010054 Zn binding residues [ion binding]; other site 315730010055 substrate binding site [chemical binding]; other site 315730010056 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730010057 active site 315730010058 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730010059 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730010060 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730010061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730010062 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 315730010063 dimer interface [polypeptide binding]; other site 315730010064 putative metal binding site [ion binding]; other site 315730010065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730010066 PAS domain; Region: PAS_9; pfam13426 315730010067 putative active site [active] 315730010068 heme pocket [chemical binding]; other site 315730010069 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730010070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730010071 putative active site [active] 315730010072 heme pocket [chemical binding]; other site 315730010073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730010074 dimer interface [polypeptide binding]; other site 315730010075 phosphorylation site [posttranslational modification] 315730010076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730010077 ATP binding site [chemical binding]; other site 315730010078 Mg2+ binding site [ion binding]; other site 315730010079 G-X-G motif; other site 315730010080 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730010081 Phosphotransferase enzyme family; Region: APH; pfam01636 315730010082 active site 315730010083 substrate binding site [chemical binding]; other site 315730010084 ATP binding site [chemical binding]; other site 315730010085 Predicted esterase [General function prediction only]; Region: COG0400 315730010086 putative hydrolase; Provisional; Region: PRK11460 315730010087 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730010088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730010089 Zn binding site [ion binding]; other site 315730010090 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730010091 Zn binding site [ion binding]; other site 315730010092 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 315730010093 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730010094 Na binding site [ion binding]; other site 315730010095 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 315730010096 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315730010097 active site 315730010098 FMN binding site [chemical binding]; other site 315730010099 substrate binding site [chemical binding]; other site 315730010100 3Fe-4S cluster binding site [ion binding]; other site 315730010101 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 315730010102 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 315730010103 FMN binding site [chemical binding]; other site 315730010104 active site 315730010105 substrate binding site [chemical binding]; other site 315730010106 catalytic residue [active] 315730010107 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 315730010108 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 315730010109 catalytic Zn binding site [ion binding]; other site 315730010110 NAD binding site [chemical binding]; other site 315730010111 structural Zn binding site [ion binding]; other site 315730010112 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 315730010113 Agmatinase-like family; Region: Agmatinase-like; cd09990 315730010114 active site 315730010115 oligomer interface [polypeptide binding]; other site 315730010116 Mn binding site [ion binding]; other site 315730010117 imidazolonepropionase; Validated; Region: PRK09356 315730010118 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 315730010119 active site 315730010120 urocanate hydratase; Provisional; Region: PRK05414 315730010121 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 315730010122 active sites [active] 315730010123 tetramer interface [polypeptide binding]; other site 315730010124 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 315730010125 hexamer interface [polypeptide binding]; other site 315730010126 RNA binding site [nucleotide binding]; other site 315730010127 Histidine-zinc binding site [chemical binding]; other site 315730010128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730010129 S-adenosylmethionine binding site [chemical binding]; other site 315730010130 DJ-1 family protein; Region: not_thiJ; TIGR01383 315730010131 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 315730010132 conserved cys residue [active] 315730010133 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 315730010134 AAA domain; Region: AAA_28; pfam13521 315730010135 active site 315730010136 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 315730010137 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 315730010138 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 315730010139 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 315730010140 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730010141 EamA-like transporter family; Region: EamA; pfam00892 315730010142 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 315730010143 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730010144 metal binding site [ion binding]; metal-binding site 315730010145 dimer interface [polypeptide binding]; other site 315730010146 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315730010147 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 315730010148 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730010149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010150 Walker A/P-loop; other site 315730010151 ATP binding site [chemical binding]; other site 315730010152 Q-loop/lid; other site 315730010153 ABC transporter signature motif; other site 315730010154 Walker B; other site 315730010155 D-loop; other site 315730010156 H-loop/switch region; other site 315730010157 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315730010158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730010159 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 315730010160 putative dimerization interface [polypeptide binding]; other site 315730010161 putative substrate binding pocket [chemical binding]; other site 315730010162 holin-like protein; Validated; Region: PRK01658 315730010163 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 315730010164 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730010165 nudix motif; other site 315730010166 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 315730010167 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730010168 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730010169 amidase catalytic site [active] 315730010170 Zn binding residues [ion binding]; other site 315730010171 substrate binding site [chemical binding]; other site 315730010172 S-layer homology domain; Region: SLH; pfam00395 315730010173 S-layer homology domain; Region: SLH; pfam00395 315730010174 S-layer homology domain; Region: SLH; pfam00395 315730010175 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 315730010176 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730010177 active site 315730010178 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730010179 Bacterial SH3 domain homologues; Region: SH3b; smart00287 315730010180 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730010181 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730010182 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 315730010183 Walker A/P-loop; other site 315730010184 ATP binding site [chemical binding]; other site 315730010185 Q-loop/lid; other site 315730010186 ABC transporter signature motif; other site 315730010187 Walker B; other site 315730010188 D-loop; other site 315730010189 H-loop/switch region; other site 315730010190 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730010191 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315730010192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010193 Walker A/P-loop; other site 315730010194 ATP binding site [chemical binding]; other site 315730010195 Q-loop/lid; other site 315730010196 ABC transporter signature motif; other site 315730010197 Walker B; other site 315730010198 D-loop; other site 315730010199 H-loop/switch region; other site 315730010200 hypothetical protein; Provisional; Region: PRK01844 315730010201 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 315730010202 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 315730010203 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 315730010204 TPP-binding site [chemical binding]; other site 315730010205 dimer interface [polypeptide binding]; other site 315730010206 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315730010207 PYR/PP interface [polypeptide binding]; other site 315730010208 dimer interface [polypeptide binding]; other site 315730010209 TPP binding site [chemical binding]; other site 315730010210 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730010211 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 315730010212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730010213 dimer interface [polypeptide binding]; other site 315730010214 conserved gate region; other site 315730010215 ABC-ATPase subunit interface; other site 315730010216 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 315730010217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730010218 dimer interface [polypeptide binding]; other site 315730010219 conserved gate region; other site 315730010220 ABC-ATPase subunit interface; other site 315730010221 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 315730010222 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 315730010223 Walker A/P-loop; other site 315730010224 ATP binding site [chemical binding]; other site 315730010225 Q-loop/lid; other site 315730010226 ABC transporter signature motif; other site 315730010227 Walker B; other site 315730010228 D-loop; other site 315730010229 H-loop/switch region; other site 315730010230 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 315730010231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730010232 membrane-bound complex binding site; other site 315730010233 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730010234 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730010235 active site 315730010236 metal binding site [ion binding]; metal-binding site 315730010237 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730010238 hypothetical protein; Provisional; Region: PRK01546 315730010239 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730010240 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730010241 catalytic residues [active] 315730010242 catalytic nucleophile [active] 315730010243 LexA repressor; Validated; Region: PRK00215 315730010244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730010245 putative DNA binding site [nucleotide binding]; other site 315730010246 putative Zn2+ binding site [ion binding]; other site 315730010247 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 315730010248 Catalytic site [active] 315730010249 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 315730010250 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315730010251 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 315730010252 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730010253 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730010254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730010255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010256 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730010257 Walker A/P-loop; other site 315730010258 ATP binding site [chemical binding]; other site 315730010259 Q-loop/lid; other site 315730010260 ABC transporter signature motif; other site 315730010261 Walker B; other site 315730010262 D-loop; other site 315730010263 H-loop/switch region; other site 315730010264 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 315730010265 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 315730010266 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 315730010267 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 315730010268 active site 315730010269 metal-binding site [ion binding] 315730010270 nucleotide-binding site [chemical binding]; other site 315730010271 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730010272 active site 315730010273 dimer interface [polypeptide binding]; other site 315730010274 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 315730010275 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730010276 Ligand Binding Site [chemical binding]; other site 315730010277 Molecular Tunnel; other site 315730010278 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 315730010279 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315730010280 inhibitor-cofactor binding pocket; inhibition site 315730010281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730010282 catalytic residue [active] 315730010283 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 315730010284 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 315730010285 putative trimer interface [polypeptide binding]; other site 315730010286 putative CoA binding site [chemical binding]; other site 315730010287 Bacterial sugar transferase; Region: Bac_transf; pfam02397 315730010288 Right handed beta helix region; Region: Beta_helix; pfam13229 315730010289 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 315730010290 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 315730010291 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730010292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730010293 active site 315730010294 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730010295 putative ADP-binding pocket [chemical binding]; other site 315730010296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010298 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730010299 putative ADP-binding pocket [chemical binding]; other site 315730010300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010301 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730010302 putative ADP-binding pocket [chemical binding]; other site 315730010303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010304 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730010305 putative ADP-binding pocket [chemical binding]; other site 315730010306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010307 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315730010308 putative ADP-binding pocket [chemical binding]; other site 315730010309 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730010310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730010311 active site 315730010312 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010313 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315730010314 putative ADP-binding pocket [chemical binding]; other site 315730010315 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315730010316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730010317 putative ADP-binding pocket [chemical binding]; other site 315730010318 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315730010319 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730010320 NAD(P) binding site [chemical binding]; other site 315730010321 homodimer interface [polypeptide binding]; other site 315730010322 substrate binding site [chemical binding]; other site 315730010323 active site 315730010324 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730010325 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315730010326 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315730010327 Chain length determinant protein; Region: Wzz; cl15801 315730010328 Helix-turn-helix domain; Region: HTH_17; pfam12728 315730010329 Helix-turn-helix domain; Region: HTH_17; pfam12728 315730010330 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730010331 amidase catalytic site [active] 315730010332 Zn binding residues [ion binding]; other site 315730010333 substrate binding site [chemical binding]; other site 315730010334 Bacterial SH3 domain; Region: SH3_3; cl17532 315730010335 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730010336 Holin family; Region: Phage_holin_4; pfam05105 315730010337 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730010338 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 315730010339 Phage tail protein; Region: Sipho_tail; pfam05709 315730010340 Phage tail protein; Region: Sipho_tail; cl17486 315730010341 membrane protein P6; Region: PHA01399 315730010342 membrane protein P6; Region: PHA01399 315730010343 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730010344 active site 315730010345 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730010346 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730010347 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 315730010348 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 315730010349 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 315730010350 Phage capsid family; Region: Phage_capsid; pfam05065 315730010351 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 315730010352 Phage portal protein; Region: Phage_portal; pfam04860 315730010353 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730010354 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730010355 HNH endonuclease; Region: HNH; pfam01844 315730010356 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 315730010357 Helix-turn-helix domain; Region: HTH_17; pfam12728 315730010358 PLD-like domain; Region: PLDc_2; pfam13091 315730010359 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 315730010360 putative active site [active] 315730010361 catalytic site [active] 315730010362 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 315730010363 putative active site [active] 315730010364 catalytic site [active] 315730010365 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 315730010366 HNH endonuclease; Region: HNH_2; pfam13391 315730010367 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 315730010368 homodimer interface [polypeptide binding]; other site 315730010369 chemical substrate binding site [chemical binding]; other site 315730010370 oligomer interface [polypeptide binding]; other site 315730010371 metal binding site [ion binding]; metal-binding site 315730010372 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730010373 active site 315730010374 TIGR02646 family protein; Region: TIGR02646 315730010375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010376 AAA domain; Region: AAA_21; pfam13304 315730010377 Walker A/P-loop; other site 315730010378 ATP binding site [chemical binding]; other site 315730010379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010380 ABC transporter signature motif; other site 315730010381 Walker B; other site 315730010382 D-loop; other site 315730010383 H-loop/switch region; other site 315730010384 positive control sigma-like factor; Validated; Region: PRK06930 315730010385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730010386 DNA binding residues [nucleotide binding] 315730010387 AAA ATPase domain; Region: AAA_15; pfam13175 315730010388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730010389 Walker A/P-loop; other site 315730010390 ATP binding site [chemical binding]; other site 315730010391 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 315730010392 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730010393 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 315730010394 Thymidylate synthase complementing protein; Region: Thy1; cl03630 315730010395 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315730010396 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 315730010397 cofactor binding site; other site 315730010398 DNA binding site [nucleotide binding] 315730010399 substrate interaction site [chemical binding]; other site 315730010400 dUTPase; Region: dUTPase_2; pfam08761 315730010401 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 315730010402 active site 315730010403 homodimer interface [polypeptide binding]; other site 315730010404 metal binding site [ion binding]; metal-binding site 315730010405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 315730010406 Uncharacterized Zn-finger containing protein [General function prediction only]; Region: COG1645 315730010407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730010408 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730010409 Walker A motif; other site 315730010410 ATP binding site [chemical binding]; other site 315730010411 Walker B motif; other site 315730010412 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 315730010413 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 315730010414 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 315730010415 Domain of unknown function (DUF771); Region: DUF771; cl09962 315730010416 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 315730010417 ORF6C domain; Region: ORF6C; pfam10552 315730010418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010419 sequence-specific DNA binding site [nucleotide binding]; other site 315730010420 salt bridge; other site 315730010421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730010422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010423 non-specific DNA binding site [nucleotide binding]; other site 315730010424 salt bridge; other site 315730010425 sequence-specific DNA binding site [nucleotide binding]; other site 315730010426 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 315730010427 Domain of unknown function (DUF955); Region: DUF955; cl01076 315730010428 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 315730010429 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315730010430 Int/Topo IB signature motif; other site 315730010431 glutamine synthetase, type I; Region: GlnA; TIGR00653 315730010432 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 315730010433 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 315730010434 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315730010435 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730010436 DNA binding residues [nucleotide binding] 315730010437 putative dimer interface [polypeptide binding]; other site 315730010438 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 315730010439 Aluminium resistance protein; Region: Alum_res; pfam06838 315730010440 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315730010441 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315730010442 HflX GTPase family; Region: HflX; cd01878 315730010443 G1 box; other site 315730010444 GTP/Mg2+ binding site [chemical binding]; other site 315730010445 Switch I region; other site 315730010446 G2 box; other site 315730010447 G3 box; other site 315730010448 Switch II region; other site 315730010449 G4 box; other site 315730010450 G5 box; other site 315730010451 Predicted membrane protein [Function unknown]; Region: COG2860 315730010452 UPF0126 domain; Region: UPF0126; pfam03458 315730010453 UPF0126 domain; Region: UPF0126; pfam03458 315730010454 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315730010455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730010456 Walker A motif; other site 315730010457 ATP binding site [chemical binding]; other site 315730010458 Walker B motif; other site 315730010459 arginine finger; other site 315730010460 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 315730010461 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 315730010462 active site 315730010463 catalytic residues [active] 315730010464 DNA binding site [nucleotide binding] 315730010465 Int/Topo IB signature motif; other site 315730010466 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 315730010467 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010468 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010469 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010470 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010471 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010472 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010473 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730010474 bacterial Hfq-like; Region: Hfq; cd01716 315730010475 hexamer interface [polypeptide binding]; other site 315730010476 Sm1 motif; other site 315730010477 RNA binding site [nucleotide binding]; other site 315730010478 Sm2 motif; other site 315730010479 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 315730010480 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 315730010481 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730010482 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730010483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315730010484 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 315730010485 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315730010486 active site 315730010487 phosphorylation site [posttranslational modification] 315730010488 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315730010489 active site 315730010490 P-loop; other site 315730010491 phosphorylation site [posttranslational modification] 315730010492 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 315730010493 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315730010494 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315730010495 putative substrate binding site [chemical binding]; other site 315730010496 putative ATP binding site [chemical binding]; other site 315730010497 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730010498 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 315730010499 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 315730010500 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315730010501 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315730010502 dimer interface [polypeptide binding]; other site 315730010503 active site 315730010504 metal binding site [ion binding]; metal-binding site 315730010505 Predicted membrane protein [Function unknown]; Region: COG2322 315730010506 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 315730010507 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 315730010508 Glyco_18 domain; Region: Glyco_18; smart00636 315730010509 putative active site [active] 315730010510 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730010511 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730010512 metal binding site [ion binding]; metal-binding site 315730010513 dimer interface [polypeptide binding]; other site 315730010514 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730010515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730010516 putative active site [active] 315730010517 putative metal binding site [ion binding]; other site 315730010518 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 315730010519 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730010520 IHF dimer interface [polypeptide binding]; other site 315730010521 IHF - DNA interface [nucleotide binding]; other site 315730010522 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730010523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730010524 Coenzyme A binding pocket [chemical binding]; other site 315730010525 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730010526 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730010527 metal-binding site [ion binding] 315730010528 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730010529 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730010530 metal-binding site [ion binding] 315730010531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730010532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730010533 motif II; other site 315730010534 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730010535 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730010536 metal-binding site [ion binding] 315730010537 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 315730010538 putative homodimer interface [polypeptide binding]; other site 315730010539 putative homotetramer interface [polypeptide binding]; other site 315730010540 allosteric switch controlling residues; other site 315730010541 putative metal binding site [ion binding]; other site 315730010542 putative homodimer-homodimer interface [polypeptide binding]; other site 315730010543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730010544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730010545 DNA binding residues [nucleotide binding] 315730010546 dimerization interface [polypeptide binding]; other site 315730010547 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730010548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730010549 S-adenosylmethionine binding site [chemical binding]; other site 315730010550 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315730010551 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730010552 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730010553 Walker A/P-loop; other site 315730010554 ATP binding site [chemical binding]; other site 315730010555 Q-loop/lid; other site 315730010556 ABC transporter signature motif; other site 315730010557 Walker B; other site 315730010558 D-loop; other site 315730010559 H-loop/switch region; other site 315730010560 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730010561 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730010562 ABC-ATPase subunit interface; other site 315730010563 dimer interface [polypeptide binding]; other site 315730010564 putative PBP binding regions; other site 315730010565 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730010566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730010567 ABC-ATPase subunit interface; other site 315730010568 dimer interface [polypeptide binding]; other site 315730010569 putative PBP binding regions; other site 315730010570 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730010571 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730010572 putative ligand binding residues [chemical binding]; other site 315730010573 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 315730010574 active site 315730010575 putative catalytic site [active] 315730010576 DNA binding site [nucleotide binding] 315730010577 putative phosphate binding site [ion binding]; other site 315730010578 metal binding site A [ion binding]; metal-binding site 315730010579 AP binding site [nucleotide binding]; other site 315730010580 metal binding site B [ion binding]; metal-binding site 315730010581 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 315730010582 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 315730010583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730010584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730010585 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 315730010586 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315730010587 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315730010588 DNA binding site [nucleotide binding] 315730010589 active site 315730010590 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 315730010591 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 315730010592 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730010593 minor groove reading motif; other site 315730010594 helix-hairpin-helix signature motif; other site 315730010595 substrate binding pocket [chemical binding]; other site 315730010596 active site 315730010597 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730010598 peptidase T; Region: peptidase-T; TIGR01882 315730010599 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 315730010600 metal binding site [ion binding]; metal-binding site 315730010601 dimer interface [polypeptide binding]; other site 315730010602 Predicted membrane protein [Function unknown]; Region: COG2364 315730010603 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730010604 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730010605 catalytic core [active] 315730010606 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730010607 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730010608 active site 315730010609 PAS domain S-box; Region: sensory_box; TIGR00229 315730010610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730010611 putative active site [active] 315730010612 heme pocket [chemical binding]; other site 315730010613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730010614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730010615 metal binding site [ion binding]; metal-binding site 315730010616 active site 315730010617 I-site; other site 315730010618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730010619 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 315730010620 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730010621 active site 315730010622 homodimer interface [polypeptide binding]; other site 315730010623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010624 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 315730010625 NAD(P) binding site [chemical binding]; other site 315730010626 active site 315730010627 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730010628 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 315730010629 NAD(P) binding site [chemical binding]; other site 315730010630 homodimer interface [polypeptide binding]; other site 315730010631 substrate binding site [chemical binding]; other site 315730010632 active site 315730010633 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315730010634 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315730010635 LrgB-like family; Region: LrgB; pfam04172 315730010636 holin-like protein; Validated; Region: PRK01658 315730010637 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730010638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010639 DNA-binding site [nucleotide binding]; DNA binding site 315730010640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730010641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730010642 homodimer interface [polypeptide binding]; other site 315730010643 catalytic residue [active] 315730010644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730010645 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 315730010646 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315730010647 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730010648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010649 DNA-binding site [nucleotide binding]; DNA binding site 315730010650 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 315730010651 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 315730010652 beta-galactosidase; Region: BGL; TIGR03356 315730010653 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 315730010654 active site 315730010655 catalytic site [active] 315730010656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730010657 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 315730010658 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730010659 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730010660 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 315730010661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730010662 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730010663 Sulfatase; Region: Sulfatase; pfam00884 315730010664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730010665 binding surface 315730010666 TPR motif; other site 315730010667 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 315730010668 G1 box; other site 315730010669 GTP/Mg2+ binding site [chemical binding]; other site 315730010670 G2 box; other site 315730010671 Switch I region; other site 315730010672 G3 box; other site 315730010673 Switch II region; other site 315730010674 G4 box; other site 315730010675 G5 box; other site 315730010676 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 315730010677 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 315730010678 active site 315730010679 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 315730010680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730010681 ATP binding site [chemical binding]; other site 315730010682 Mg2+ binding site [ion binding]; other site 315730010683 G-X-G motif; other site 315730010684 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 315730010685 ATP binding site [chemical binding]; other site 315730010686 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 315730010687 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 315730010688 MutS domain I; Region: MutS_I; pfam01624 315730010689 MutS domain II; Region: MutS_II; pfam05188 315730010690 MutS domain III; Region: MutS_III; pfam05192 315730010691 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 315730010692 Walker A/P-loop; other site 315730010693 ATP binding site [chemical binding]; other site 315730010694 Q-loop/lid; other site 315730010695 ABC transporter signature motif; other site 315730010696 Walker B; other site 315730010697 D-loop; other site 315730010698 H-loop/switch region; other site 315730010699 Outer spore coat protein E (CotE); Region: CotE; pfam10628 315730010700 Predicted membrane protein [Function unknown]; Region: COG4550 315730010701 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 315730010702 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315730010703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730010704 FeS/SAM binding site; other site 315730010705 TRAM domain; Region: TRAM; pfam01938 315730010706 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 315730010707 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 315730010708 TPP-binding site [chemical binding]; other site 315730010709 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 315730010710 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 315730010711 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 315730010712 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 315730010713 dimer interface [polypeptide binding]; other site 315730010714 PYR/PP interface [polypeptide binding]; other site 315730010715 TPP binding site [chemical binding]; other site 315730010716 substrate binding site [chemical binding]; other site 315730010717 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730010718 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 315730010719 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 315730010720 active site 315730010721 dimer interface [polypeptide binding]; other site 315730010722 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 315730010723 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 315730010724 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730010725 putative active site [active] 315730010726 metal binding site [ion binding]; metal-binding site 315730010727 homodimer binding site [polypeptide binding]; other site 315730010728 phosphodiesterase; Provisional; Region: PRK12704 315730010729 Uncharacterized conserved protein [Function unknown]; Region: COG3334 315730010730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730010731 Zn2+ binding site [ion binding]; other site 315730010732 Mg2+ binding site [ion binding]; other site 315730010733 recombinase A; Provisional; Region: recA; PRK09354 315730010734 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 315730010735 hexamer interface [polypeptide binding]; other site 315730010736 Walker A motif; other site 315730010737 ATP binding site [chemical binding]; other site 315730010738 Walker B motif; other site 315730010739 competence damage-inducible protein A; Provisional; Region: PRK00549 315730010740 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 315730010741 putative MPT binding site; other site 315730010742 Competence-damaged protein; Region: CinA; pfam02464 315730010743 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 315730010744 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 315730010745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010746 non-specific DNA binding site [nucleotide binding]; other site 315730010747 salt bridge; other site 315730010748 sequence-specific DNA binding site [nucleotide binding]; other site 315730010749 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 315730010750 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 315730010751 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 315730010752 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 315730010753 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315730010754 classical (c) SDRs; Region: SDR_c; cd05233 315730010755 NAD(P) binding site [chemical binding]; other site 315730010756 active site 315730010757 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010758 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315730010759 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010760 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010761 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010762 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730010763 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315730010764 TM-ABC transporter signature motif; other site 315730010765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 315730010766 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315730010767 TM-ABC transporter signature motif; other site 315730010768 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 315730010769 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 315730010770 Walker A/P-loop; other site 315730010771 ATP binding site [chemical binding]; other site 315730010772 Q-loop/lid; other site 315730010773 ABC transporter signature motif; other site 315730010774 Walker B; other site 315730010775 D-loop; other site 315730010776 H-loop/switch region; other site 315730010777 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 315730010778 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315730010779 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315730010780 ligand binding site [chemical binding]; other site 315730010781 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730010782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010783 DNA-binding site [nucleotide binding]; DNA binding site 315730010784 UTRA domain; Region: UTRA; pfam07702 315730010785 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315730010786 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730010787 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 315730010788 YlzJ-like protein; Region: YlzJ; pfam14035 315730010789 Clp protease; Region: CLP_protease; pfam00574 315730010790 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 315730010791 active site 315730010792 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315730010793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730010794 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730010795 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 315730010796 dihydrodipicolinate synthase; Region: dapA; TIGR00674 315730010797 dimer interface [polypeptide binding]; other site 315730010798 active site 315730010799 catalytic residue [active] 315730010800 aspartate kinase I; Reviewed; Region: PRK08210 315730010801 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 315730010802 nucleotide binding site [chemical binding]; other site 315730010803 substrate binding site [chemical binding]; other site 315730010804 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 315730010805 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 315730010806 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 315730010807 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 315730010808 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 315730010809 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730010810 active site 315730010811 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 315730010812 Holin family; Region: Phage_holin_4; pfam05105 315730010813 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 315730010814 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730010815 Phage tail protein; Region: Sipho_tail; pfam05709 315730010816 Phage tail protein; Region: Sipho_tail; cl17486 315730010817 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 315730010818 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 315730010819 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730010820 membrane protein P6; Region: PHA01399 315730010821 Phage-related protein [Function unknown]; Region: COG5412 315730010822 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730010823 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 315730010824 Phage capsid family; Region: Phage_capsid; pfam05065 315730010825 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 315730010826 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 315730010827 oligomer interface [polypeptide binding]; other site 315730010828 active site residues [active] 315730010829 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 315730010830 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730010831 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730010832 Phage terminase, small subunit; Region: Terminase_4; cl01525 315730010833 HNH endonuclease; Region: HNH; pfam01844 315730010834 active site 315730010835 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730010836 DNA-binding site [nucleotide binding]; DNA binding site 315730010837 RNA-binding motif; other site 315730010838 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 315730010839 Int/Topo IB signature motif; other site 315730010840 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730010841 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 315730010842 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730010843 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 315730010844 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 315730010845 replicative DNA helicase; Provisional; Region: PRK06749 315730010846 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730010847 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730010848 Walker A motif; other site 315730010849 ATP binding site [chemical binding]; other site 315730010850 Walker B motif; other site 315730010851 DNA binding loops [nucleotide binding] 315730010852 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 315730010853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010854 non-specific DNA binding site [nucleotide binding]; other site 315730010855 salt bridge; other site 315730010856 sequence-specific DNA binding site [nucleotide binding]; other site 315730010857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730010858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010859 non-specific DNA binding site [nucleotide binding]; other site 315730010860 salt bridge; other site 315730010861 sequence-specific DNA binding site [nucleotide binding]; other site 315730010862 Domain of unknown function (DUF955); Region: DUF955; pfam06114 315730010863 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730010864 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730010865 catalytic residues [active] 315730010866 catalytic nucleophile [active] 315730010867 Recombinase; Region: Recombinase; pfam07508 315730010868 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 315730010869 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 315730010870 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 315730010871 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 315730010872 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 315730010873 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010874 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315730010875 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010876 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 315730010877 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 315730010878 NodB motif; other site 315730010879 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 315730010880 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 315730010881 RNase E interface [polypeptide binding]; other site 315730010882 trimer interface [polypeptide binding]; other site 315730010883 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 315730010884 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 315730010885 RNase E interface [polypeptide binding]; other site 315730010886 trimer interface [polypeptide binding]; other site 315730010887 active site 315730010888 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 315730010889 putative nucleic acid binding region [nucleotide binding]; other site 315730010890 G-X-X-G motif; other site 315730010891 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 315730010892 RNA binding site [nucleotide binding]; other site 315730010893 domain interface; other site 315730010894 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 315730010895 16S/18S rRNA binding site [nucleotide binding]; other site 315730010896 S13e-L30e interaction site [polypeptide binding]; other site 315730010897 25S rRNA binding site [nucleotide binding]; other site 315730010898 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 315730010899 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 315730010900 active site 315730010901 Riboflavin kinase; Region: Flavokinase; pfam01687 315730010902 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 315730010903 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 315730010904 RNA binding site [nucleotide binding]; other site 315730010905 active site 315730010906 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 315730010907 Protein of unknown function (DUF503); Region: DUF503; pfam04456 315730010908 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315730010909 translation initiation factor IF-2; Region: IF-2; TIGR00487 315730010910 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315730010911 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 315730010912 G1 box; other site 315730010913 putative GEF interaction site [polypeptide binding]; other site 315730010914 GTP/Mg2+ binding site [chemical binding]; other site 315730010915 Switch I region; other site 315730010916 G2 box; other site 315730010917 G3 box; other site 315730010918 Switch II region; other site 315730010919 G4 box; other site 315730010920 G5 box; other site 315730010921 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 315730010922 Translation-initiation factor 2; Region: IF-2; pfam11987 315730010923 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 315730010924 hypothetical protein; Provisional; Region: PRK07714 315730010925 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 315730010926 putative RNA binding cleft [nucleotide binding]; other site 315730010927 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 315730010928 NusA N-terminal domain; Region: NusA_N; pfam08529 315730010929 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 315730010930 RNA binding site [nucleotide binding]; other site 315730010931 homodimer interface [polypeptide binding]; other site 315730010932 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 315730010933 G-X-X-G motif; other site 315730010934 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 315730010935 G-X-X-G motif; other site 315730010936 ribosome maturation protein RimP; Reviewed; Region: PRK00092 315730010937 Sm and related proteins; Region: Sm_like; cl00259 315730010938 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 315730010939 putative oligomer interface [polypeptide binding]; other site 315730010940 putative RNA binding site [nucleotide binding]; other site 315730010941 DNA polymerase III PolC; Validated; Region: polC; PRK00448 315730010942 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 315730010943 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 315730010944 generic binding surface II; other site 315730010945 generic binding surface I; other site 315730010946 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315730010947 active site 315730010948 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730010949 active site 315730010950 catalytic site [active] 315730010951 substrate binding site [chemical binding]; other site 315730010952 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 315730010953 prolyl-tRNA synthetase; Provisional; Region: PRK09194 315730010954 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 315730010955 dimer interface [polypeptide binding]; other site 315730010956 motif 1; other site 315730010957 active site 315730010958 motif 2; other site 315730010959 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 315730010960 putative deacylase active site [active] 315730010961 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 315730010962 active site 315730010963 motif 3; other site 315730010964 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 315730010965 anticodon binding site; other site 315730010966 RIP metalloprotease RseP; Region: TIGR00054 315730010967 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315730010968 active site 315730010969 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 315730010970 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315730010971 protein binding site [polypeptide binding]; other site 315730010972 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315730010973 putative substrate binding region [chemical binding]; other site 315730010974 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 315730010975 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315730010976 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315730010977 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315730010978 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 315730010979 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 315730010980 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 315730010981 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 315730010982 catalytic residue [active] 315730010983 putative FPP diphosphate binding site; other site 315730010984 putative FPP binding hydrophobic cleft; other site 315730010985 dimer interface [polypeptide binding]; other site 315730010986 putative IPP diphosphate binding site; other site 315730010987 ribosome recycling factor; Reviewed; Region: frr; PRK00083 315730010988 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 315730010989 hinge region; other site 315730010990 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315730010991 putative nucleotide binding site [chemical binding]; other site 315730010992 uridine monophosphate binding site [chemical binding]; other site 315730010993 homohexameric interface [polypeptide binding]; other site 315730010994 elongation factor Ts; Provisional; Region: tsf; PRK09377 315730010995 UBA/TS-N domain; Region: UBA; pfam00627 315730010996 Elongation factor TS; Region: EF_TS; pfam00889 315730010997 Elongation factor TS; Region: EF_TS; pfam00889 315730010998 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 315730010999 rRNA interaction site [nucleotide binding]; other site 315730011000 S8 interaction site; other site 315730011001 putative laminin-1 binding site; other site 315730011002 transcriptional repressor CodY; Validated; Region: PRK04158 315730011003 CodY GAF-like domain; Region: CodY; pfam06018 315730011004 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 315730011005 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 315730011006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730011007 Walker A motif; other site 315730011008 ATP binding site [chemical binding]; other site 315730011009 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 315730011010 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315730011011 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 315730011012 active site 315730011013 HslU subunit interaction site [polypeptide binding]; other site 315730011014 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 315730011015 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315730011016 active site 315730011017 Int/Topo IB signature motif; other site 315730011018 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 315730011019 Glucose inhibited division protein A; Region: GIDA; pfam01134 315730011020 DNA topoisomerase I; Validated; Region: PRK05582 315730011021 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 315730011022 active site 315730011023 interdomain interaction site; other site 315730011024 putative metal-binding site [ion binding]; other site 315730011025 nucleotide binding site [chemical binding]; other site 315730011026 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730011027 domain I; other site 315730011028 DNA binding groove [nucleotide binding] 315730011029 phosphate binding site [ion binding]; other site 315730011030 domain II; other site 315730011031 domain III; other site 315730011032 nucleotide binding site [chemical binding]; other site 315730011033 catalytic site [active] 315730011034 domain IV; other site 315730011035 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730011036 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730011037 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 315730011038 DNA protecting protein DprA; Region: dprA; TIGR00732 315730011039 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 315730011040 CoA binding domain; Region: CoA_binding; smart00881 315730011041 CoA-ligase; Region: Ligase_CoA; pfam00549 315730011042 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 315730011043 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 315730011044 CoA-ligase; Region: Ligase_CoA; pfam00549 315730011045 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 315730011046 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730011047 active site 315730011048 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 315730011049 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 315730011050 GTP/Mg2+ binding site [chemical binding]; other site 315730011051 G4 box; other site 315730011052 G5 box; other site 315730011053 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 315730011054 G1 box; other site 315730011055 G1 box; other site 315730011056 GTP/Mg2+ binding site [chemical binding]; other site 315730011057 Switch I region; other site 315730011058 G2 box; other site 315730011059 G2 box; other site 315730011060 G3 box; other site 315730011061 G3 box; other site 315730011062 Switch II region; other site 315730011063 Switch II region; other site 315730011064 G4 box; other site 315730011065 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730011066 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730011067 Catalytic site [active] 315730011068 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730011069 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 315730011070 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 315730011071 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 315730011072 RimM N-terminal domain; Region: RimM; pfam01782 315730011073 PRC-barrel domain; Region: PRC; pfam05239 315730011074 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 315730011075 KH domain; Region: KH_4; pfam13083 315730011076 G-X-X-G motif; other site 315730011077 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 315730011078 signal recognition particle protein; Provisional; Region: PRK10867 315730011079 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 315730011080 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315730011081 P loop; other site 315730011082 GTP binding site [chemical binding]; other site 315730011083 Signal peptide binding domain; Region: SRP_SPB; pfam02978 315730011084 putative DNA-binding protein; Validated; Region: PRK00118 315730011085 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 315730011086 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 315730011087 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 315730011088 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315730011089 P loop; other site 315730011090 GTP binding site [chemical binding]; other site 315730011091 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315730011092 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 315730011093 Walker A/P-loop; other site 315730011094 ATP binding site [chemical binding]; other site 315730011095 Q-loop/lid; other site 315730011096 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 315730011097 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 315730011098 ABC transporter signature motif; other site 315730011099 Walker B; other site 315730011100 D-loop; other site 315730011101 H-loop/switch region; other site 315730011102 ribonuclease III; Reviewed; Region: rnc; PRK00102 315730011103 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315730011104 dimerization interface [polypeptide binding]; other site 315730011105 active site 315730011106 metal binding site [ion binding]; metal-binding site 315730011107 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 315730011108 dsRNA binding site [nucleotide binding]; other site 315730011109 acyl carrier protein; Provisional; Region: acpP; PRK00982 315730011110 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315730011111 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315730011112 NAD(P) binding site [chemical binding]; other site 315730011113 homotetramer interface [polypeptide binding]; other site 315730011114 homodimer interface [polypeptide binding]; other site 315730011115 active site 315730011116 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 315730011117 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315730011118 putative phosphate acyltransferase; Provisional; Region: PRK05331 315730011119 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 315730011120 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 315730011121 active site 2 [active] 315730011122 active site 1 [active] 315730011123 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 315730011124 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 315730011125 generic binding surface II; other site 315730011126 ssDNA binding site; other site 315730011127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730011128 ATP binding site [chemical binding]; other site 315730011129 putative Mg++ binding site [ion binding]; other site 315730011130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730011131 nucleotide binding region [chemical binding]; other site 315730011132 ATP-binding site [chemical binding]; other site 315730011133 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 315730011134 DAK2 domain; Region: Dak2; pfam02734 315730011135 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 315730011136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 315730011137 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 315730011138 Thiamine pyrophosphokinase; Region: TPK; cd07995 315730011139 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 315730011140 active site 315730011141 dimerization interface [polypeptide binding]; other site 315730011142 thiamine binding site [chemical binding]; other site 315730011143 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 315730011144 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315730011145 substrate binding site [chemical binding]; other site 315730011146 hexamer interface [polypeptide binding]; other site 315730011147 metal binding site [ion binding]; metal-binding site 315730011148 GTPase RsgA; Reviewed; Region: PRK00098 315730011149 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 315730011150 RNA binding site [nucleotide binding]; other site 315730011151 homodimer interface [polypeptide binding]; other site 315730011152 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315730011153 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315730011154 GTP/Mg2+ binding site [chemical binding]; other site 315730011155 G4 box; other site 315730011156 G5 box; other site 315730011157 G1 box; other site 315730011158 Switch I region; other site 315730011159 G2 box; other site 315730011160 G3 box; other site 315730011161 Switch II region; other site 315730011162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315730011163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315730011164 active site 315730011165 ATP binding site [chemical binding]; other site 315730011166 substrate binding site [chemical binding]; other site 315730011167 activation loop (A-loop); other site 315730011168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 315730011169 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315730011170 PASTA domain; Region: PASTA; pfam03793 315730011171 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315730011172 Protein phosphatase 2C; Region: PP2C; pfam00481 315730011173 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 315730011174 active site 315730011175 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 315730011176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011177 FeS/SAM binding site; other site 315730011178 16S rRNA methyltransferase B; Provisional; Region: PRK14902 315730011179 NusB family; Region: NusB; pfam01029 315730011180 putative RNA binding site [nucleotide binding]; other site 315730011181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011182 S-adenosylmethionine binding site [chemical binding]; other site 315730011183 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 315730011184 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 315730011185 putative active site [active] 315730011186 substrate binding site [chemical binding]; other site 315730011187 putative cosubstrate binding site; other site 315730011188 catalytic site [active] 315730011189 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 315730011190 substrate binding site [chemical binding]; other site 315730011191 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315730011192 active site 315730011193 catalytic residues [active] 315730011194 metal binding site [ion binding]; metal-binding site 315730011195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730011196 primosomal protein N' Region: priA; TIGR00595 315730011197 ATP binding site [chemical binding]; other site 315730011198 putative Mg++ binding site [ion binding]; other site 315730011199 helicase superfamily c-terminal domain; Region: HELICc; smart00490 315730011200 nucleotide binding region [chemical binding]; other site 315730011201 ATP-binding site [chemical binding]; other site 315730011202 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 315730011203 Flavoprotein; Region: Flavoprotein; pfam02441 315730011204 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 315730011205 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 315730011206 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 315730011207 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 315730011208 catalytic site [active] 315730011209 G-X2-G-X-G-K; other site 315730011210 hypothetical protein; Provisional; Region: PRK04323 315730011211 hypothetical protein; Provisional; Region: PRK11820 315730011212 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 315730011213 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 315730011214 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 315730011215 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315730011216 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730011217 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730011218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011219 motif II; other site 315730011220 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730011221 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 315730011222 Domain of unknown function (DUF814); Region: DUF814; pfam05670 315730011223 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730011224 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730011225 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730011226 active site 315730011227 Protein of unknown function (DUF664); Region: DUF664; pfam04978 315730011228 DinB superfamily; Region: DinB_2; pfam12867 315730011229 YoqO-like protein; Region: YoqO; pfam14037 315730011230 YoqO-like protein; Region: YoqO; pfam14037 315730011231 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730011232 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730011233 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004 315730011234 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 315730011235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730011236 active site 315730011237 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 315730011238 active site 315730011239 dimer interface [polypeptide binding]; other site 315730011240 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 315730011241 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 315730011242 heterodimer interface [polypeptide binding]; other site 315730011243 active site 315730011244 FMN binding site [chemical binding]; other site 315730011245 homodimer interface [polypeptide binding]; other site 315730011246 substrate binding site [chemical binding]; other site 315730011247 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 315730011248 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 315730011249 FAD binding pocket [chemical binding]; other site 315730011250 FAD binding motif [chemical binding]; other site 315730011251 phosphate binding motif [ion binding]; other site 315730011252 beta-alpha-beta structure motif; other site 315730011253 NAD binding pocket [chemical binding]; other site 315730011254 Iron coordination center [ion binding]; other site 315730011255 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 315730011256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730011257 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315730011258 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315730011259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730011260 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315730011261 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 315730011262 IMP binding site; other site 315730011263 dimer interface [polypeptide binding]; other site 315730011264 interdomain contacts; other site 315730011265 partial ornithine binding site; other site 315730011266 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 315730011267 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 315730011268 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315730011269 catalytic site [active] 315730011270 subunit interface [polypeptide binding]; other site 315730011271 dihydroorotase; Validated; Region: pyrC; PRK09357 315730011272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730011273 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 315730011274 active site 315730011275 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 315730011276 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315730011277 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 315730011278 uracil transporter; Provisional; Region: PRK10720 315730011279 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 315730011280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730011281 active site 315730011282 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 315730011283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730011284 RNA binding surface [nucleotide binding]; other site 315730011285 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315730011286 active site 315730011287 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 315730011288 lipoprotein signal peptidase; Provisional; Region: PRK14787 315730011289 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315730011290 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 315730011291 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315730011292 active site 315730011293 HIGH motif; other site 315730011294 nucleotide binding site [chemical binding]; other site 315730011295 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730011296 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730011297 active site 315730011298 KMSKS motif; other site 315730011299 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 315730011300 tRNA binding surface [nucleotide binding]; other site 315730011301 anticodon binding site; other site 315730011302 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315730011303 DivIVA protein; Region: DivIVA; pfam05103 315730011304 DivIVA domain; Region: DivI1A_domain; TIGR03544 315730011305 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 315730011306 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 315730011307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730011308 RNA binding surface [nucleotide binding]; other site 315730011309 YGGT family; Region: YGGT; pfam02325 315730011310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 315730011311 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 315730011312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730011313 catalytic residue [active] 315730011314 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 315730011315 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 315730011316 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 315730011317 sporulation sigma factor SigG; Reviewed; Region: PRK08215 315730011318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011319 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730011320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011321 DNA binding residues [nucleotide binding] 315730011322 sporulation sigma factor SigE; Reviewed; Region: PRK08301 315730011323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011325 DNA binding residues [nucleotide binding] 315730011326 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 315730011327 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 315730011328 cell division protein FtsZ; Validated; Region: PRK09330 315730011329 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 315730011330 nucleotide binding site [chemical binding]; other site 315730011331 SulA interaction site; other site 315730011332 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 315730011333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315730011334 nucleotide binding site [chemical binding]; other site 315730011335 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 315730011336 Cell division protein FtsA; Region: FtsA; pfam14450 315730011337 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 315730011338 Cell division protein FtsQ; Region: FtsQ; pfam03799 315730011339 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 315730011340 FAD binding domain; Region: FAD_binding_4; pfam01565 315730011341 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315730011342 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 315730011343 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730011344 active site 315730011345 homodimer interface [polypeptide binding]; other site 315730011346 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730011347 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 315730011348 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 315730011349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730011350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730011351 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 315730011352 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 315730011353 Mg++ binding site [ion binding]; other site 315730011354 putative catalytic motif [active] 315730011355 putative substrate binding site [chemical binding]; other site 315730011356 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 315730011357 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730011358 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730011359 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730011360 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315730011361 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730011362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730011363 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 315730011364 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730011365 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730011366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730011367 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315730011368 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315730011369 Cell division protein FtsL; Region: FtsL; cl11433 315730011370 MraW methylase family; Region: Methyltransf_5; pfam01795 315730011371 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 315730011372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 315730011373 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 315730011374 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 315730011375 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 315730011376 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315730011377 hypothetical protein; Provisional; Region: PRK13688 315730011378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011379 Coenzyme A binding pocket [chemical binding]; other site 315730011380 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730011381 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730011382 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 315730011383 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 315730011384 hypothetical protein; Provisional; Region: PRK13670 315730011385 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 315730011386 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 315730011387 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 315730011388 protein binding site [polypeptide binding]; other site 315730011389 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315730011390 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315730011391 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 315730011392 active site 315730011393 nucleophile elbow; other site 315730011394 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 315730011395 Nucleoside recognition; Region: Gate; pfam07670 315730011396 Nucleoside recognition; Region: Gate; pfam07670 315730011397 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 315730011398 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 315730011399 active site 315730011400 (T/H)XGH motif; other site 315730011401 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 315730011402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011403 S-adenosylmethionine binding site [chemical binding]; other site 315730011404 hypothetical protein; Provisional; Region: PRK02886 315730011405 Protein of unknown function (DUF964); Region: DUF964; pfam06133 315730011406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730011407 catalytic core [active] 315730011408 YlbE-like protein; Region: YlbE; pfam14003 315730011409 Putative coat protein; Region: YlbD_coat; pfam14071 315730011410 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315730011411 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315730011412 YugN-like family; Region: YugN; pfam08868 315730011413 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 315730011414 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315730011415 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315730011416 Subunit I/III interface [polypeptide binding]; other site 315730011417 Subunit III/IV interface [polypeptide binding]; other site 315730011418 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315730011419 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315730011420 D-pathway; other site 315730011421 Putative ubiquinol binding site [chemical binding]; other site 315730011422 Low-spin heme (heme b) binding site [chemical binding]; other site 315730011423 Putative water exit pathway; other site 315730011424 Binuclear center (heme o3/CuB) [ion binding]; other site 315730011425 K-pathway; other site 315730011426 Putative proton exit pathway; other site 315730011427 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 315730011428 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 315730011429 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315730011430 Cytochrome c; Region: Cytochrom_C; pfam00034 315730011431 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 315730011432 UbiA prenyltransferase family; Region: UbiA; pfam01040 315730011433 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 315730011434 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 315730011435 pyruvate carboxylase; Reviewed; Region: PRK12999 315730011436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730011437 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 315730011438 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315730011439 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 315730011440 active site 315730011441 catalytic residues [active] 315730011442 metal binding site [ion binding]; metal-binding site 315730011443 homodimer binding site [polypeptide binding]; other site 315730011444 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730011445 carboxyltransferase (CT) interaction site; other site 315730011446 biotinylation site [posttranslational modification]; other site 315730011447 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 315730011448 hypothetical protein; Provisional; Region: PRK13666 315730011449 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 315730011450 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 315730011451 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 315730011452 putative active site [active] 315730011453 PhoH-like protein; Region: PhoH; pfam02562 315730011454 hypothetical protein; Provisional; Region: PRK06733 315730011455 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 315730011456 YlaH-like protein; Region: YlaH; pfam14036 315730011457 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 315730011458 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 315730011459 G1 box; other site 315730011460 putative GEF interaction site [polypeptide binding]; other site 315730011461 GTP/Mg2+ binding site [chemical binding]; other site 315730011462 Switch I region; other site 315730011463 G2 box; other site 315730011464 G3 box; other site 315730011465 Switch II region; other site 315730011466 G4 box; other site 315730011467 G5 box; other site 315730011468 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 315730011469 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 315730011470 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 315730011471 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 315730011472 active site 315730011473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 315730011474 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 315730011475 hypothetical protein; Provisional; Region: PRK04387 315730011476 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315730011477 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315730011478 homodimer interface [polypeptide binding]; other site 315730011479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011480 catalytic residue [active] 315730011481 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315730011482 transglutaminase; Provisional; Region: tgl; PRK03187 315730011483 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730011484 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730011485 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730011486 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730011487 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 315730011488 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315730011489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730011490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730011491 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730011492 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730011493 E3 interaction surface; other site 315730011494 lipoyl attachment site [posttranslational modification]; other site 315730011495 e3 binding domain; Region: E3_binding; pfam02817 315730011496 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315730011497 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730011498 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730011499 alpha subunit interface [polypeptide binding]; other site 315730011500 TPP binding site [chemical binding]; other site 315730011501 heterodimer interface [polypeptide binding]; other site 315730011502 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730011503 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 315730011504 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315730011505 TPP-binding site [chemical binding]; other site 315730011506 heterodimer interface [polypeptide binding]; other site 315730011507 tetramer interface [polypeptide binding]; other site 315730011508 phosphorylation loop region [posttranslational modification] 315730011509 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315730011510 active site 315730011511 catalytic residues [active] 315730011512 metal binding site [ion binding]; metal-binding site 315730011513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011514 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730011515 active site 315730011516 motif I; other site 315730011517 motif II; other site 315730011518 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730011519 hypothetical protein; Provisional; Region: PRK13667 315730011520 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315730011521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730011522 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730011523 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730011524 TrkA-N domain; Region: TrkA_N; pfam02254 315730011525 TrkA-C domain; Region: TrkA_C; pfam02080 315730011526 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 315730011527 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730011528 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 315730011529 metal binding site [ion binding]; metal-binding site 315730011530 putative dimer interface [polypeptide binding]; other site 315730011531 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 315730011532 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 315730011533 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 315730011534 trimer interface [polypeptide binding]; other site 315730011535 active site 315730011536 substrate binding site [chemical binding]; other site 315730011537 CoA binding site [chemical binding]; other site 315730011538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730011539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730011540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730011541 dimerization interface [polypeptide binding]; other site 315730011542 FOG: CBS domain [General function prediction only]; Region: COG0517 315730011543 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 315730011544 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 315730011545 Protein of unknown function (DUF458); Region: DUF458; pfam04308 315730011546 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 315730011547 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 315730011548 catalytic residues [active] 315730011549 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 315730011550 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730011551 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 315730011552 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 315730011553 short chain dehydrogenase; Provisional; Region: PRK07677 315730011554 NAD(P) binding site [chemical binding]; other site 315730011555 substrate binding site [chemical binding]; other site 315730011556 homotetramer interface [polypeptide binding]; other site 315730011557 active site 315730011558 homodimer interface [polypeptide binding]; other site 315730011559 phosphodiesterase YaeI; Provisional; Region: PRK11340 315730011560 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730011561 putative active site [active] 315730011562 putative metal binding site [ion binding]; other site 315730011563 polyphosphate kinase; Provisional; Region: PRK05443 315730011564 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 315730011565 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 315730011566 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 315730011567 putative domain interface [polypeptide binding]; other site 315730011568 putative active site [active] 315730011569 catalytic site [active] 315730011570 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 315730011571 putative domain interface [polypeptide binding]; other site 315730011572 putative active site [active] 315730011573 catalytic site [active] 315730011574 exopolyphosphatase; Region: exo_poly_only; TIGR03706 315730011575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315730011576 nucleotide binding site [chemical binding]; other site 315730011577 YkyB-like protein; Region: YkyB; pfam14177 315730011578 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730011579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730011580 active site 315730011581 I-site; other site 315730011582 metal binding site [ion binding]; metal-binding site 315730011583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730011584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730011585 putative substrate translocation pore; other site 315730011586 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730011587 Transcriptional regulator PadR-like family; Region: PadR; cl17335 315730011588 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 315730011589 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 315730011590 THF binding site; other site 315730011591 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315730011592 substrate binding site [chemical binding]; other site 315730011593 THF binding site; other site 315730011594 zinc-binding site [ion binding]; other site 315730011595 Competence protein J (ComJ); Region: ComJ; pfam11033 315730011596 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315730011597 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 315730011598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730011599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730011600 dimer interface [polypeptide binding]; other site 315730011601 phosphorylation site [posttranslational modification] 315730011602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730011603 ATP binding site [chemical binding]; other site 315730011604 Mg2+ binding site [ion binding]; other site 315730011605 G-X-G motif; other site 315730011606 aminotransferase A; Validated; Region: PRK07683 315730011607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730011608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011609 homodimer interface [polypeptide binding]; other site 315730011610 catalytic residue [active] 315730011611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730011612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730011613 DNA binding site [nucleotide binding] 315730011614 domain linker motif; other site 315730011615 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 315730011616 putative dimerization interface [polypeptide binding]; other site 315730011617 putative ligand binding site [chemical binding]; other site 315730011618 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315730011619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730011620 dimer interface [polypeptide binding]; other site 315730011621 conserved gate region; other site 315730011622 putative PBP binding loops; other site 315730011623 ABC-ATPase subunit interface; other site 315730011624 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 315730011625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730011626 dimer interface [polypeptide binding]; other site 315730011627 conserved gate region; other site 315730011628 putative PBP binding loops; other site 315730011629 ABC-ATPase subunit interface; other site 315730011630 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 315730011631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 315730011632 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 315730011633 homodimer interface [polypeptide binding]; other site 315730011634 maltodextrin glucosidase; Provisional; Region: PRK10785 315730011635 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 315730011636 active site 315730011637 homodimer interface [polypeptide binding]; other site 315730011638 catalytic site [active] 315730011639 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730011640 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730011641 Ca binding site [ion binding]; other site 315730011642 active site 315730011643 catalytic site [active] 315730011644 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730011645 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 315730011646 Walker A/P-loop; other site 315730011647 ATP binding site [chemical binding]; other site 315730011648 Q-loop/lid; other site 315730011649 ABC transporter signature motif; other site 315730011650 Walker B; other site 315730011651 D-loop; other site 315730011652 H-loop/switch region; other site 315730011653 TOBE domain; Region: TOBE_2; pfam08402 315730011654 hypothetical protein; Provisional; Region: PRK06720 315730011655 NAD(P) binding site [chemical binding]; other site 315730011656 RDD family; Region: RDD; pfam06271 315730011657 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 315730011658 Predicted ATPase [General function prediction only]; Region: COG3910 315730011659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730011660 Walker A/P-loop; other site 315730011661 ATP binding site [chemical binding]; other site 315730011662 Q-loop/lid; other site 315730011663 ABC transporter signature motif; other site 315730011664 Walker B; other site 315730011665 D-loop; other site 315730011666 H-loop/switch region; other site 315730011667 putative acyltransferase; Provisional; Region: PRK05790 315730011668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730011669 dimer interface [polypeptide binding]; other site 315730011670 active site 315730011671 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730011672 nudix motif; other site 315730011673 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 315730011674 hypothetical protein; Validated; Region: PRK07668 315730011675 hypothetical protein; Validated; Region: PRK07668 315730011676 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730011677 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730011678 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 315730011679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011680 NAD(P) binding site [chemical binding]; other site 315730011681 active site 315730011682 YvrJ protein family; Region: YvrJ; pfam12841 315730011683 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315730011684 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 315730011685 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 315730011686 Phosphotransferase enzyme family; Region: APH; pfam01636 315730011687 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315730011688 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 315730011689 putative active site [active] 315730011690 catalytic triad [active] 315730011691 putative dimer interface [polypeptide binding]; other site 315730011692 transaminase; Reviewed; Region: PRK08068 315730011693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730011694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011695 homodimer interface [polypeptide binding]; other site 315730011696 catalytic residue [active] 315730011697 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 315730011698 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 315730011699 dimer interface [polypeptide binding]; other site 315730011700 active site 315730011701 catalytic residue [active] 315730011702 metal binding site [ion binding]; metal-binding site 315730011703 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 315730011704 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 315730011705 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 315730011706 intersubunit interface [polypeptide binding]; other site 315730011707 active site 315730011708 Zn2+ binding site [ion binding]; other site 315730011709 ARD/ARD' family; Region: ARD; pfam03079 315730011710 Cupin domain; Region: Cupin_2; pfam07883 315730011711 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 315730011712 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315730011713 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 315730011714 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730011715 Beta-lactamase; Region: Beta-lactamase; pfam00144 315730011716 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730011717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730011718 metal binding site [ion binding]; metal-binding site 315730011719 active site 315730011720 I-site; other site 315730011721 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315730011722 dimer interface [polypeptide binding]; other site 315730011723 FMN binding site [chemical binding]; other site 315730011724 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 315730011725 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 315730011726 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 315730011727 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 315730011728 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 315730011729 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315730011730 dimerization domain swap beta strand [polypeptide binding]; other site 315730011731 regulatory protein interface [polypeptide binding]; other site 315730011732 active site 315730011733 regulatory phosphorylation site [posttranslational modification]; other site 315730011734 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 315730011735 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 315730011736 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730011737 active site turn [active] 315730011738 phosphorylation site [posttranslational modification] 315730011739 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315730011740 HPr interaction site; other site 315730011741 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315730011742 active site 315730011743 phosphorylation site [posttranslational modification] 315730011744 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315730011745 CAT RNA binding domain; Region: CAT_RBD; smart01061 315730011746 PRD domain; Region: PRD; pfam00874 315730011747 PRD domain; Region: PRD; pfam00874 315730011748 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730011749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011750 active site 315730011751 motif I; other site 315730011752 motif II; other site 315730011753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011754 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730011755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730011756 DNA-binding site [nucleotide binding]; DNA binding site 315730011757 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 315730011758 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 315730011759 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 315730011760 active site 315730011761 trimer interface [polypeptide binding]; other site 315730011762 allosteric site; other site 315730011763 active site lid [active] 315730011764 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315730011765 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 315730011766 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 315730011767 active site 315730011768 dimer interface [polypeptide binding]; other site 315730011769 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 315730011770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730011771 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 315730011772 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 315730011773 Domain of unknown function (DUF309); Region: DUF309; pfam03745 315730011774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011775 Coenzyme A binding pocket [chemical binding]; other site 315730011776 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 315730011777 active site 315730011778 Predicted secreted protein [Function unknown]; Region: COG4086 315730011779 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 315730011780 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730011781 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 315730011782 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730011783 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730011784 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 315730011785 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 315730011786 stage V sporulation protein AD; Validated; Region: PRK08304 315730011787 stage V sporulation protein AD; Provisional; Region: PRK12404 315730011788 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 315730011789 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 315730011790 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 315730011791 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 315730011792 Na2 binding site [ion binding]; other site 315730011793 putative substrate binding site 1 [chemical binding]; other site 315730011794 Na binding site 1 [ion binding]; other site 315730011795 putative substrate binding site 2 [chemical binding]; other site 315730011796 sporulation sigma factor SigF; Validated; Region: PRK05572 315730011797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011798 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730011799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011800 DNA binding residues [nucleotide binding] 315730011801 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315730011802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730011803 ATP binding site [chemical binding]; other site 315730011804 Mg2+ binding site [ion binding]; other site 315730011805 G-X-G motif; other site 315730011806 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 315730011807 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730011808 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730011809 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 315730011810 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730011811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730011812 DNA-binding site [nucleotide binding]; DNA binding site 315730011813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730011814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730011815 Walker A/P-loop; other site 315730011816 ATP binding site [chemical binding]; other site 315730011817 Q-loop/lid; other site 315730011818 ABC transporter signature motif; other site 315730011819 Walker B; other site 315730011820 D-loop; other site 315730011821 H-loop/switch region; other site 315730011822 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315730011823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730011824 MarR family; Region: MarR; pfam01047 315730011825 MarR family; Region: MarR_2; cl17246 315730011826 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 315730011827 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730011828 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 315730011829 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 315730011830 oligomer interface [polypeptide binding]; other site 315730011831 metal binding site [ion binding]; metal-binding site 315730011832 metal binding site [ion binding]; metal-binding site 315730011833 putative Cl binding site [ion binding]; other site 315730011834 aspartate ring; other site 315730011835 basic sphincter; other site 315730011836 hydrophobic gate; other site 315730011837 periplasmic entrance; other site 315730011838 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315730011839 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730011840 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730011841 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 315730011842 purine nucleoside phosphorylase; Provisional; Region: PRK08202 315730011843 phosphopentomutase; Provisional; Region: PRK05362 315730011844 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 315730011845 YtkA-like; Region: YtkA; pfam13115 315730011846 YtkA-like; Region: YtkA; pfam13115 315730011847 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315730011848 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 315730011849 active site 315730011850 Int/Topo IB signature motif; other site 315730011851 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 315730011852 ferric uptake regulator; Provisional; Region: fur; PRK09462 315730011853 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730011854 metal binding site 2 [ion binding]; metal-binding site 315730011855 putative DNA binding helix; other site 315730011856 metal binding site 1 [ion binding]; metal-binding site 315730011857 dimer interface [polypeptide binding]; other site 315730011858 structural Zn2+ binding site [ion binding]; other site 315730011859 stage II sporulation protein M; Region: spo_II_M; TIGR02831 315730011860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730011861 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730011862 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 315730011863 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 315730011864 dimer interface [polypeptide binding]; other site 315730011865 ADP-ribose binding site [chemical binding]; other site 315730011866 active site 315730011867 nudix motif; other site 315730011868 metal binding site [ion binding]; metal-binding site 315730011869 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 315730011870 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730011871 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730011872 active site 315730011873 catalytic tetrad [active] 315730011874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730011875 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730011876 active site 315730011877 catalytic tetrad [active] 315730011878 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 315730011879 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730011880 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315730011881 putative active site [active] 315730011882 putative metal binding site [ion binding]; other site 315730011883 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730011884 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 315730011885 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730011886 Predicted permease [General function prediction only]; Region: COG2056 315730011887 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 315730011888 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 315730011889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730011890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730011891 DNA binding site [nucleotide binding] 315730011892 domain linker motif; other site 315730011893 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 315730011894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011895 Coenzyme A binding pocket [chemical binding]; other site 315730011896 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730011897 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 315730011898 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 315730011899 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315730011900 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315730011901 catalytic motif [active] 315730011902 Zn binding site [ion binding]; other site 315730011903 RibD C-terminal domain; Region: RibD_C; cl17279 315730011904 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 315730011905 Lumazine binding domain; Region: Lum_binding; pfam00677 315730011906 Lumazine binding domain; Region: Lum_binding; pfam00677 315730011907 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 315730011908 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 315730011909 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315730011910 dimerization interface [polypeptide binding]; other site 315730011911 active site 315730011912 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 315730011913 homopentamer interface [polypeptide binding]; other site 315730011914 active site 315730011915 biotin synthase; Validated; Region: PRK06256 315730011916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011917 FeS/SAM binding site; other site 315730011918 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 315730011919 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 315730011920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011921 S-adenosylmethionine binding site [chemical binding]; other site 315730011922 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 315730011923 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 315730011924 TAP-like protein; Region: Abhydrolase_4; pfam08386 315730011925 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 315730011926 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315730011927 substrate-cofactor binding pocket; other site 315730011928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011929 catalytic residue [active] 315730011930 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 315730011931 AAA domain; Region: AAA_26; pfam13500 315730011932 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 315730011933 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730011934 inhibitor-cofactor binding pocket; inhibition site 315730011935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011936 catalytic residue [active] 315730011937 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730011938 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 315730011939 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730011940 active site 315730011941 metal binding site [ion binding]; metal-binding site 315730011942 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730011943 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315730011944 active site 315730011945 catalytic triad [active] 315730011946 oxyanion hole [active] 315730011947 MarR family; Region: MarR; pfam01047 315730011948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730011949 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 315730011950 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730011951 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730011952 ornithine carbamoyltransferase; Provisional; Region: PRK00779 315730011953 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315730011954 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 315730011955 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 315730011956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730011957 inhibitor-cofactor binding pocket; inhibition site 315730011958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011959 catalytic residue [active] 315730011960 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 315730011961 nucleotide binding site [chemical binding]; other site 315730011962 N-acetyl-L-glutamate binding site [chemical binding]; other site 315730011963 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 315730011964 heterotetramer interface [polypeptide binding]; other site 315730011965 active site pocket [active] 315730011966 cleavage site 315730011967 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 315730011968 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 315730011969 YqzH-like protein; Region: YqzH; pfam14164 315730011970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011971 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 315730011972 NAD(P) binding site [chemical binding]; other site 315730011973 active site 315730011974 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730011975 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 315730011976 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315730011977 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315730011978 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315730011979 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 315730011980 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315730011981 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 315730011982 putative L-serine binding site [chemical binding]; other site 315730011983 ribonuclease Z; Region: RNase_Z; TIGR02651 315730011984 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 315730011985 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 315730011986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730011987 Walker A/P-loop; other site 315730011988 ATP binding site [chemical binding]; other site 315730011989 Q-loop/lid; other site 315730011990 ABC transporter signature motif; other site 315730011991 Walker B; other site 315730011992 D-loop; other site 315730011993 H-loop/switch region; other site 315730011994 magnesium-transporting ATPase; Provisional; Region: PRK15122 315730011995 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 315730011996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730011997 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730011998 Soluble P-type ATPase [General function prediction only]; Region: COG4087 315730011999 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730012000 MgtC family; Region: MgtC; pfam02308 315730012001 DNA polymerase IV; Validated; Region: PRK01810 315730012002 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 315730012003 active site 315730012004 DNA binding site [nucleotide binding] 315730012005 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 315730012006 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 315730012007 peptidase T-like protein; Region: PepT-like; TIGR01883 315730012008 metal binding site [ion binding]; metal-binding site 315730012009 putative dimer interface [polypeptide binding]; other site 315730012010 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730012011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730012012 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 315730012013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 315730012014 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315730012015 Predicted membrane protein [Function unknown]; Region: COG4129 315730012016 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 315730012017 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 315730012018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730012019 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730012020 Probable transposase; Region: OrfB_IS605; pfam01385 315730012021 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 315730012022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730012023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 315730012024 Walker A/P-loop; other site 315730012025 ATP binding site [chemical binding]; other site 315730012026 Q-loop/lid; other site 315730012027 ABC transporter signature motif; other site 315730012028 Walker B; other site 315730012029 D-loop; other site 315730012030 H-loop/switch region; other site 315730012031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730012032 dimer interface [polypeptide binding]; other site 315730012033 conserved gate region; other site 315730012034 putative PBP binding loops; other site 315730012035 ABC-ATPase subunit interface; other site 315730012036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730012037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730012038 substrate binding pocket [chemical binding]; other site 315730012039 membrane-bound complex binding site; other site 315730012040 hinge residues; other site 315730012041 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315730012042 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 315730012043 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730012044 nudix motif; other site 315730012045 Predicted membrane protein [Function unknown]; Region: COG2323 315730012046 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 315730012047 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730012048 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730012049 E3 interaction surface; other site 315730012050 lipoyl attachment site [posttranslational modification]; other site 315730012051 e3 binding domain; Region: E3_binding; pfam02817 315730012052 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 315730012053 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730012054 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730012055 alpha subunit interface [polypeptide binding]; other site 315730012056 TPP binding site [chemical binding]; other site 315730012057 heterodimer interface [polypeptide binding]; other site 315730012058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730012059 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315730012060 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315730012061 tetramer interface [polypeptide binding]; other site 315730012062 TPP-binding site [chemical binding]; other site 315730012063 heterodimer interface [polypeptide binding]; other site 315730012064 phosphorylation loop region [posttranslational modification] 315730012065 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 315730012066 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 315730012067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730012068 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730012069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315730012070 nucleotide binding site [chemical binding]; other site 315730012071 Acetokinase family; Region: Acetate_kinase; cl17229 315730012072 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730012073 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730012074 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 315730012075 NAD binding site [chemical binding]; other site 315730012076 Phe binding site; other site 315730012077 phosphate butyryltransferase; Validated; Region: PRK07742 315730012078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315730012079 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730012080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730012081 putative active site [active] 315730012082 heme pocket [chemical binding]; other site 315730012083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730012084 putative active site [active] 315730012085 heme pocket [chemical binding]; other site 315730012086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012087 Walker A motif; other site 315730012088 ATP binding site [chemical binding]; other site 315730012089 Walker B motif; other site 315730012090 arginine finger; other site 315730012091 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 315730012092 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 315730012093 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730012094 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315730012095 active site 315730012096 catalytic site [active] 315730012097 metal binding site [ion binding]; metal-binding site 315730012098 dimer interface [polypeptide binding]; other site 315730012099 YycC-like protein; Region: YycC; pfam14174 315730012100 hypothetical protein; Provisional; Region: PRK06770 315730012101 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730012102 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730012103 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730012104 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730012105 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730012106 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730012107 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 315730012108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730012109 active site 315730012110 phosphorylation site [posttranslational modification] 315730012111 intermolecular recognition site; other site 315730012112 dimerization interface [polypeptide binding]; other site 315730012113 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 315730012114 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 315730012115 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315730012116 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 315730012117 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 315730012118 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 315730012119 Walker A/P-loop; other site 315730012120 ATP binding site [chemical binding]; other site 315730012121 Q-loop/lid; other site 315730012122 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 315730012123 ABC transporter signature motif; other site 315730012124 Walker B; other site 315730012125 D-loop; other site 315730012126 H-loop/switch region; other site 315730012127 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 315730012128 arginine repressor; Provisional; Region: PRK04280 315730012129 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 315730012130 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 315730012131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730012132 RNA binding surface [nucleotide binding]; other site 315730012133 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 315730012134 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 315730012135 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 315730012136 TPP-binding site; other site 315730012137 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315730012138 PYR/PP interface [polypeptide binding]; other site 315730012139 dimer interface [polypeptide binding]; other site 315730012140 TPP binding site [chemical binding]; other site 315730012141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730012142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315730012143 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315730012144 substrate binding pocket [chemical binding]; other site 315730012145 chain length determination region; other site 315730012146 substrate-Mg2+ binding site; other site 315730012147 catalytic residues [active] 315730012148 aspartate-rich region 1; other site 315730012149 active site lid residues [active] 315730012150 aspartate-rich region 2; other site 315730012151 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 315730012152 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 315730012153 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 315730012154 generic binding surface II; other site 315730012155 generic binding surface I; other site 315730012156 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 315730012157 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 315730012158 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 315730012159 homodimer interface [polypeptide binding]; other site 315730012160 NADP binding site [chemical binding]; other site 315730012161 substrate binding site [chemical binding]; other site 315730012162 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 315730012163 putative RNA binding site [nucleotide binding]; other site 315730012164 Asp23 family; Region: Asp23; pfam03780 315730012165 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 315730012166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730012167 ATP-grasp domain; Region: ATP-grasp_4; cl17255 315730012168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 315730012169 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 315730012170 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730012171 carboxyltransferase (CT) interaction site; other site 315730012172 biotinylation site [posttranslational modification]; other site 315730012173 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 315730012174 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 315730012175 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 315730012176 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 315730012177 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 315730012178 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 315730012179 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 315730012180 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 315730012181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012182 Walker A motif; other site 315730012183 ATP binding site [chemical binding]; other site 315730012184 Walker B motif; other site 315730012185 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 315730012186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730012187 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730012188 elongation factor P; Validated; Region: PRK00529 315730012189 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 315730012190 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 315730012191 RNA binding site [nucleotide binding]; other site 315730012192 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 315730012193 RNA binding site [nucleotide binding]; other site 315730012194 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730012195 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730012196 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730012197 active site 315730012198 Dehydroquinase class II; Region: DHquinase_II; pfam01220 315730012199 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 315730012200 trimer interface [polypeptide binding]; other site 315730012201 active site 315730012202 dimer interface [polypeptide binding]; other site 315730012203 Conserved membrane protein YqhR; Region: YqhR; pfam11085 315730012204 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 315730012205 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730012206 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 315730012207 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 315730012208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730012209 motif II; other site 315730012210 manganese transport transcriptional regulator; Provisional; Region: PRK03902 315730012211 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 315730012212 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 315730012213 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 315730012214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730012215 FeS/SAM binding site; other site 315730012216 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730012217 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730012218 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315730012219 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730012220 active site residue [active] 315730012221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730012222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730012223 DNA binding site [nucleotide binding] 315730012224 domain linker motif; other site 315730012225 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730012226 putative dimerization interface [polypeptide binding]; other site 315730012227 putative ligand binding site [chemical binding]; other site 315730012228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730012229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730012230 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315730012231 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 315730012232 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 315730012233 Domain of unknown function (DUF202); Region: DUF202; cl09954 315730012234 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730012235 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730012236 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730012237 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730012238 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730012239 Walker A/P-loop; other site 315730012240 ATP binding site [chemical binding]; other site 315730012241 Q-loop/lid; other site 315730012242 ABC transporter signature motif; other site 315730012243 Walker B; other site 315730012244 D-loop; other site 315730012245 H-loop/switch region; other site 315730012246 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730012247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730012248 DNA-binding site [nucleotide binding]; DNA binding site 315730012249 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 315730012250 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315730012251 tetramer interface [polypeptide binding]; other site 315730012252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012253 catalytic residue [active] 315730012254 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 315730012255 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315730012256 tetramer interface [polypeptide binding]; other site 315730012257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012258 catalytic residue [active] 315730012259 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 315730012260 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 315730012261 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 315730012262 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730012263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730012264 ATP binding site [chemical binding]; other site 315730012265 putative Mg++ binding site [ion binding]; other site 315730012266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730012267 nucleotide binding region [chemical binding]; other site 315730012268 ATP-binding site [chemical binding]; other site 315730012269 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 315730012270 YqzE-like protein; Region: YqzE; pfam14038 315730012271 shikimate kinase; Reviewed; Region: aroK; PRK00131 315730012272 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 315730012273 ADP binding site [chemical binding]; other site 315730012274 magnesium binding site [ion binding]; other site 315730012275 putative shikimate binding site; other site 315730012276 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 315730012277 ComG operon protein 7; Region: ComGG; pfam14173 315730012278 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 315730012279 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 315730012280 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 315730012281 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 315730012282 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 315730012283 Type II/IV secretion system protein; Region: T2SE; pfam00437 315730012284 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 315730012285 Walker A motif; other site 315730012286 ATP binding site [chemical binding]; other site 315730012287 Walker B motif; other site 315730012288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730012289 putative DNA binding site [nucleotide binding]; other site 315730012290 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 315730012291 putative Zn2+ binding site [ion binding]; other site 315730012292 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 315730012293 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 315730012294 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730012295 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 315730012296 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 315730012297 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 315730012298 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 315730012299 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 315730012300 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730012301 active site 315730012302 homodimer interface [polypeptide binding]; other site 315730012303 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 315730012304 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 315730012305 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 315730012306 substrate binding pocket [chemical binding]; other site 315730012307 dimer interface [polypeptide binding]; other site 315730012308 inhibitor binding site; inhibition site 315730012309 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 315730012310 B12 binding site [chemical binding]; other site 315730012311 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 315730012312 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 315730012313 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315730012314 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 315730012315 FAD binding site [chemical binding]; other site 315730012316 cystathionine gamma-synthase; Reviewed; Region: PRK08247 315730012317 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730012318 homodimer interface [polypeptide binding]; other site 315730012319 substrate-cofactor binding pocket; other site 315730012320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012321 catalytic residue [active] 315730012322 cystathionine beta-lyase; Provisional; Region: PRK08064 315730012323 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730012324 homodimer interface [polypeptide binding]; other site 315730012325 substrate-cofactor binding pocket; other site 315730012326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012327 catalytic residue [active] 315730012328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730012329 dimerization interface [polypeptide binding]; other site 315730012330 putative DNA binding site [nucleotide binding]; other site 315730012331 putative Zn2+ binding site [ion binding]; other site 315730012332 Uncharacterized conserved protein [Function unknown]; Region: COG1565 315730012333 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730012334 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 315730012335 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 315730012336 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 315730012337 nucleotide binding site [chemical binding]; other site 315730012338 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 315730012339 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 315730012340 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 315730012341 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 315730012342 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 315730012343 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 315730012344 active site 315730012345 Substrate binding site; other site 315730012346 Mg++ binding site; other site 315730012347 putative trimer interface [polypeptide binding]; other site 315730012348 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 315730012349 putative CoA binding site [chemical binding]; other site 315730012350 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315730012351 putative trimer interface [polypeptide binding]; other site 315730012352 putative CoA binding site [chemical binding]; other site 315730012353 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 315730012354 active site 315730012355 substrate binding site [chemical binding]; other site 315730012356 metal binding site [ion binding]; metal-binding site 315730012357 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 315730012358 PhoU domain; Region: PhoU; pfam01895 315730012359 PhoU domain; Region: PhoU; pfam01895 315730012360 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 315730012361 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 315730012362 Walker A/P-loop; other site 315730012363 ATP binding site [chemical binding]; other site 315730012364 Q-loop/lid; other site 315730012365 ABC transporter signature motif; other site 315730012366 Walker B; other site 315730012367 D-loop; other site 315730012368 H-loop/switch region; other site 315730012369 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 315730012370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730012371 dimer interface [polypeptide binding]; other site 315730012372 conserved gate region; other site 315730012373 putative PBP binding loops; other site 315730012374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730012375 ABC-ATPase subunit interface; other site 315730012376 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 315730012377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730012378 dimer interface [polypeptide binding]; other site 315730012379 conserved gate region; other site 315730012380 putative PBP binding loops; other site 315730012381 ABC-ATPase subunit interface; other site 315730012382 PBP superfamily domain; Region: PBP_like_2; cl17296 315730012383 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730012384 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730012385 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730012386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730012387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730012388 putative substrate translocation pore; other site 315730012389 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730012390 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730012391 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730012392 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 315730012393 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 315730012394 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315730012395 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315730012396 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730012397 metal binding site 2 [ion binding]; metal-binding site 315730012398 putative DNA binding helix; other site 315730012399 metal binding site 1 [ion binding]; metal-binding site 315730012400 dimer interface [polypeptide binding]; other site 315730012401 structural Zn2+ binding site [ion binding]; other site 315730012402 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 315730012403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730012404 ABC-ATPase subunit interface; other site 315730012405 dimer interface [polypeptide binding]; other site 315730012406 putative PBP binding regions; other site 315730012407 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 315730012408 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 315730012409 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730012410 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730012411 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730012412 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 315730012413 endonuclease IV; Provisional; Region: PRK01060 315730012414 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 315730012415 AP (apurinic/apyrimidinic) site pocket; other site 315730012416 DNA interaction; other site 315730012417 Metal-binding active site; metal-binding site 315730012418 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730012419 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730012420 ATP binding site [chemical binding]; other site 315730012421 Mg++ binding site [ion binding]; other site 315730012422 motif III; other site 315730012423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730012424 nucleotide binding region [chemical binding]; other site 315730012425 ATP-binding site [chemical binding]; other site 315730012426 YqfQ-like protein; Region: YqfQ; pfam14181 315730012427 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 315730012428 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 315730012429 Uncharacterized conserved protein [Function unknown]; Region: COG0327 315730012430 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 315730012431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 315730012432 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 315730012433 Uncharacterized conserved protein [Function unknown]; Region: COG0327 315730012434 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 315730012435 Family of unknown function (DUF633); Region: DUF633; pfam04816 315730012436 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315730012437 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315730012438 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 315730012439 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 315730012440 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 315730012441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730012442 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730012443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730012444 DNA binding residues [nucleotide binding] 315730012445 DNA primase; Validated; Region: dnaG; PRK05667 315730012446 CHC2 zinc finger; Region: zf-CHC2; pfam01807 315730012447 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 315730012448 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 315730012449 active site 315730012450 metal binding site [ion binding]; metal-binding site 315730012451 interdomain interaction site; other site 315730012452 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 315730012453 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 315730012454 PEP synthetase regulatory protein; Provisional; Region: PRK05339 315730012455 HTH domain; Region: HTH_11; pfam08279 315730012456 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 315730012457 FOG: CBS domain [General function prediction only]; Region: COG0517 315730012458 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 315730012459 Recombination protein O N terminal; Region: RecO_N; pfam11967 315730012460 Recombination protein O C terminal; Region: RecO_C; pfam02565 315730012461 YqzL-like protein; Region: YqzL; pfam14006 315730012462 GTPase Era; Reviewed; Region: era; PRK00089 315730012463 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 315730012464 G1 box; other site 315730012465 GTP/Mg2+ binding site [chemical binding]; other site 315730012466 Switch I region; other site 315730012467 G2 box; other site 315730012468 Switch II region; other site 315730012469 G3 box; other site 315730012470 G4 box; other site 315730012471 G5 box; other site 315730012472 KH domain; Region: KH_2; pfam07650 315730012473 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315730012474 active site 315730012475 catalytic motif [active] 315730012476 Zn binding site [ion binding]; other site 315730012477 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 315730012478 metal-binding heat shock protein; Provisional; Region: PRK00016 315730012479 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 315730012480 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 315730012481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730012482 Zn2+ binding site [ion binding]; other site 315730012483 Mg2+ binding site [ion binding]; other site 315730012484 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 315730012485 PhoH-like protein; Region: PhoH; pfam02562 315730012486 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 315730012487 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 315730012488 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 315730012489 Yqey-like protein; Region: YqeY; pfam09424 315730012490 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 315730012491 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 315730012492 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315730012493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730012494 FeS/SAM binding site; other site 315730012495 TRAM domain; Region: TRAM; cl01282 315730012496 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 315730012497 RNA methyltransferase, RsmE family; Region: TIGR00046 315730012498 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 315730012499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012500 S-adenosylmethionine binding site [chemical binding]; other site 315730012501 chaperone protein DnaJ; Provisional; Region: PRK14280 315730012502 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315730012503 HSP70 interaction site [polypeptide binding]; other site 315730012504 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 315730012505 substrate binding site [polypeptide binding]; other site 315730012506 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 315730012507 Zn binding sites [ion binding]; other site 315730012508 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 315730012509 dimer interface [polypeptide binding]; other site 315730012510 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315730012511 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 315730012512 nucleotide binding site [chemical binding]; other site 315730012513 NEF interaction site [polypeptide binding]; other site 315730012514 SBD interface [polypeptide binding]; other site 315730012515 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 315730012516 heat shock protein GrpE; Provisional; Region: PRK14140 315730012517 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 315730012518 dimer interface [polypeptide binding]; other site 315730012519 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 315730012520 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 315730012521 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 315730012522 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 315730012523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730012524 FeS/SAM binding site; other site 315730012525 HemN C-terminal domain; Region: HemN_C; pfam06969 315730012526 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730012527 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315730012528 GTP-binding protein LepA; Provisional; Region: PRK05433 315730012529 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 315730012530 G1 box; other site 315730012531 putative GEF interaction site [polypeptide binding]; other site 315730012532 GTP/Mg2+ binding site [chemical binding]; other site 315730012533 Switch I region; other site 315730012534 G2 box; other site 315730012535 G3 box; other site 315730012536 Switch II region; other site 315730012537 G4 box; other site 315730012538 G5 box; other site 315730012539 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 315730012540 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 315730012541 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 315730012542 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 315730012543 germination protease; Provisional; Region: PRK02858 315730012544 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 315730012545 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 315730012546 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 315730012547 YqzM-like protein; Region: YqzM; pfam14141 315730012548 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 315730012549 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 315730012550 Competence protein; Region: Competence; pfam03772 315730012551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730012552 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 315730012553 catalytic motif [active] 315730012554 Zn binding site [ion binding]; other site 315730012555 SLBB domain; Region: SLBB; pfam10531 315730012556 comEA protein; Region: comE; TIGR01259 315730012557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 315730012558 late competence protein ComER; Validated; Region: PRK07680 315730012559 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 315730012560 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 315730012561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012562 S-adenosylmethionine binding site [chemical binding]; other site 315730012563 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 315730012564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730012565 Zn2+ binding site [ion binding]; other site 315730012566 Mg2+ binding site [ion binding]; other site 315730012567 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 315730012568 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 315730012569 active site 315730012570 (T/H)XGH motif; other site 315730012571 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 315730012572 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 315730012573 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315730012574 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315730012575 shikimate binding site; other site 315730012576 NAD(P) binding site [chemical binding]; other site 315730012577 GTPase YqeH; Provisional; Region: PRK13796 315730012578 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 315730012579 GTP/Mg2+ binding site [chemical binding]; other site 315730012580 G4 box; other site 315730012581 G5 box; other site 315730012582 G1 box; other site 315730012583 Switch I region; other site 315730012584 G2 box; other site 315730012585 G3 box; other site 315730012586 Switch II region; other site 315730012587 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 315730012588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730012589 active site 315730012590 motif I; other site 315730012591 motif II; other site 315730012592 Sporulation inhibitor A; Region: Sda; pfam08970 315730012593 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 315730012594 sporulation sigma factor SigK; Reviewed; Region: PRK05803 315730012595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730012596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730012597 DNA binding residues [nucleotide binding] 315730012598 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730012599 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730012600 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315730012601 synthetase active site [active] 315730012602 NTP binding site [chemical binding]; other site 315730012603 metal binding site [ion binding]; metal-binding site 315730012604 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315730012605 dimer interface [polypeptide binding]; other site 315730012606 Alkaline phosphatase homologues; Region: alkPPc; smart00098 315730012607 active site 315730012608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730012609 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730012610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730012611 Coenzyme A binding pocket [chemical binding]; other site 315730012612 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 315730012613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730012614 Predicted membrane protein [Function unknown]; Region: COG2259 315730012615 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 315730012616 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315730012617 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 315730012618 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315730012619 putative active site [active] 315730012620 catalytic triad [active] 315730012621 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 315730012622 putative integrin binding motif; other site 315730012623 PA/protease domain interface [polypeptide binding]; other site 315730012624 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315730012625 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 315730012626 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 315730012627 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 315730012628 cofactor binding site; other site 315730012629 metal binding site [ion binding]; metal-binding site 315730012630 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 315730012631 aromatic arch; other site 315730012632 DCoH dimer interaction site [polypeptide binding]; other site 315730012633 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 315730012634 DCoH tetramer interaction site [polypeptide binding]; other site 315730012635 substrate binding site [chemical binding]; other site 315730012636 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730012637 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315730012638 putative metal binding site [ion binding]; other site 315730012639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730012640 active site 315730012641 Predicted membrane protein [Function unknown]; Region: COG2259 315730012642 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730012643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730012644 non-specific DNA binding site [nucleotide binding]; other site 315730012645 salt bridge; other site 315730012646 sequence-specific DNA binding site [nucleotide binding]; other site 315730012647 Cupin domain; Region: Cupin_2; pfam07883 315730012648 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315730012649 active site 2 [active] 315730012650 active site 1 [active] 315730012651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730012652 Coenzyme A binding pocket [chemical binding]; other site 315730012653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730012654 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730012655 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730012656 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730012657 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730012658 Walker A/P-loop; other site 315730012659 ATP binding site [chemical binding]; other site 315730012660 Q-loop/lid; other site 315730012661 ABC transporter signature motif; other site 315730012662 Walker B; other site 315730012663 D-loop; other site 315730012664 H-loop/switch region; other site 315730012665 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730012666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730012667 ABC-ATPase subunit interface; other site 315730012668 dimer interface [polypeptide binding]; other site 315730012669 putative PBP binding regions; other site 315730012670 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730012671 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730012672 YrhC-like protein; Region: YrhC; pfam14143 315730012673 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 315730012674 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 315730012675 putative catalytic cysteine [active] 315730012676 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 315730012677 putative active site [active] 315730012678 metal binding site [ion binding]; metal-binding site 315730012679 cystathionine beta-lyase; Provisional; Region: PRK07671 315730012680 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730012681 homodimer interface [polypeptide binding]; other site 315730012682 substrate-cofactor binding pocket; other site 315730012683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012684 catalytic residue [active] 315730012685 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730012686 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730012687 dimer interface [polypeptide binding]; other site 315730012688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012689 catalytic residue [active] 315730012690 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 315730012691 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 315730012692 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730012693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012694 S-adenosylmethionine binding site [chemical binding]; other site 315730012695 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 315730012696 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730012697 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730012698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730012699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 315730012700 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 315730012701 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 315730012702 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 315730012703 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 315730012704 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 315730012705 ATP-binding site [chemical binding]; other site 315730012706 Sugar specificity; other site 315730012707 Pyrimidine base specificity; other site 315730012708 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315730012709 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 315730012710 Peptidase family U32; Region: Peptidase_U32; pfam01136 315730012711 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315730012712 Protein of unknown function (DUF556); Region: DUF556; cl00822 315730012713 Peptidase family U32; Region: Peptidase_U32; pfam01136 315730012714 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315730012715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012716 S-adenosylmethionine binding site [chemical binding]; other site 315730012717 YceG-like family; Region: YceG; pfam02618 315730012718 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 315730012719 dimerization interface [polypeptide binding]; other site 315730012720 hypothetical protein; Provisional; Region: PRK13678 315730012721 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 315730012722 hypothetical protein; Provisional; Region: PRK05473 315730012723 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 315730012724 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 315730012725 motif 1; other site 315730012726 active site 315730012727 motif 2; other site 315730012728 motif 3; other site 315730012729 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315730012730 DHHA1 domain; Region: DHHA1; pfam02272 315730012731 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730012732 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730012733 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 315730012734 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 315730012735 AAA domain; Region: AAA_30; pfam13604 315730012736 Family description; Region: UvrD_C_2; pfam13538 315730012737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730012738 TPR motif; other site 315730012739 binding surface 315730012740 TPR repeat; Region: TPR_11; pfam13414 315730012741 TPR repeat; Region: TPR_11; pfam13414 315730012742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730012743 binding surface 315730012744 TPR motif; other site 315730012745 TPR repeat; Region: TPR_11; pfam13414 315730012746 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 315730012747 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 315730012748 Ligand Binding Site [chemical binding]; other site 315730012749 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 315730012750 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 315730012751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730012752 catalytic residue [active] 315730012753 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730012754 Transcriptional regulator; Region: Rrf2; pfam02082 315730012755 recombination factor protein RarA; Reviewed; Region: PRK13342 315730012756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012757 Walker A motif; other site 315730012758 ATP binding site [chemical binding]; other site 315730012759 Walker B motif; other site 315730012760 arginine finger; other site 315730012761 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 315730012762 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730012763 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730012764 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 315730012765 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 315730012766 putative ATP binding site [chemical binding]; other site 315730012767 putative substrate interface [chemical binding]; other site 315730012768 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 315730012769 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 315730012770 dimer interface [polypeptide binding]; other site 315730012771 anticodon binding site; other site 315730012772 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 315730012773 homodimer interface [polypeptide binding]; other site 315730012774 motif 1; other site 315730012775 active site 315730012776 motif 2; other site 315730012777 GAD domain; Region: GAD; pfam02938 315730012778 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 315730012779 motif 3; other site 315730012780 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 315730012781 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 315730012782 dimer interface [polypeptide binding]; other site 315730012783 motif 1; other site 315730012784 active site 315730012785 motif 2; other site 315730012786 motif 3; other site 315730012787 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315730012788 anticodon binding site; other site 315730012789 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 315730012790 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 315730012791 putative active site [active] 315730012792 dimerization interface [polypeptide binding]; other site 315730012793 putative tRNAtyr binding site [nucleotide binding]; other site 315730012794 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315730012795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730012796 Zn2+ binding site [ion binding]; other site 315730012797 Mg2+ binding site [ion binding]; other site 315730012798 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730012799 synthetase active site [active] 315730012800 NTP binding site [chemical binding]; other site 315730012801 metal binding site [ion binding]; metal-binding site 315730012802 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315730012803 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 315730012804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730012805 active site 315730012806 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 315730012807 DHH family; Region: DHH; pfam01368 315730012808 DHHA1 domain; Region: DHHA1; pfam02272 315730012809 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 315730012810 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730012811 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 315730012812 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 315730012813 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 315730012814 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 315730012815 Protein export membrane protein; Region: SecD_SecF; pfam02355 315730012816 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 315730012817 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730012818 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730012819 Predicted membrane protein [Function unknown]; Region: COG2323 315730012820 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 315730012821 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 315730012822 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 315730012823 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 315730012824 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 315730012825 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 315730012826 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 315730012827 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 315730012828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012829 Walker A motif; other site 315730012830 ATP binding site [chemical binding]; other site 315730012831 Walker B motif; other site 315730012832 arginine finger; other site 315730012833 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 315730012834 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 315730012835 RuvA N terminal domain; Region: RuvA_N; pfam01330 315730012836 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 315730012837 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730012838 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730012839 putative ligand binding residues [chemical binding]; other site 315730012840 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 315730012841 BofC C-terminal domain; Region: BofC_C; pfam08955 315730012842 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730012843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730012844 quinolinate synthetase; Provisional; Region: PRK09375 315730012845 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 315730012846 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 315730012847 dimerization interface [polypeptide binding]; other site 315730012848 active site 315730012849 L-aspartate oxidase; Provisional; Region: PRK08071 315730012850 L-aspartate oxidase; Provisional; Region: PRK06175 315730012851 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315730012852 cysteine desulfurase; Provisional; Region: PRK02948 315730012853 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 315730012854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730012855 catalytic residue [active] 315730012856 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 315730012857 HTH domain; Region: HTH_11; pfam08279 315730012858 3H domain; Region: 3H; pfam02829 315730012859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315730012860 MOSC domain; Region: MOSC; pfam03473 315730012861 3-alpha domain; Region: 3-alpha; pfam03475 315730012862 prephenate dehydratase; Provisional; Region: PRK11898 315730012863 Prephenate dehydratase; Region: PDT; pfam00800 315730012864 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 315730012865 putative L-Phe binding site [chemical binding]; other site 315730012866 FtsX-like permease family; Region: FtsX; pfam02687 315730012867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730012868 FtsX-like permease family; Region: FtsX; pfam02687 315730012869 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730012870 FtsX-like permease family; Region: FtsX; pfam02687 315730012871 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730012872 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730012873 Walker A/P-loop; other site 315730012874 ATP binding site [chemical binding]; other site 315730012875 Q-loop/lid; other site 315730012876 ABC transporter signature motif; other site 315730012877 Walker B; other site 315730012878 D-loop; other site 315730012879 H-loop/switch region; other site 315730012880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730012881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730012882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730012883 ATP binding site [chemical binding]; other site 315730012884 Mg2+ binding site [ion binding]; other site 315730012885 G-X-G motif; other site 315730012886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730012887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730012888 active site 315730012889 phosphorylation site [posttranslational modification] 315730012890 intermolecular recognition site; other site 315730012891 dimerization interface [polypeptide binding]; other site 315730012892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730012893 DNA binding site [nucleotide binding] 315730012894 GTPase CgtA; Reviewed; Region: obgE; PRK12297 315730012895 GTP1/OBG; Region: GTP1_OBG; pfam01018 315730012896 Obg GTPase; Region: Obg; cd01898 315730012897 G1 box; other site 315730012898 GTP/Mg2+ binding site [chemical binding]; other site 315730012899 Switch I region; other site 315730012900 G2 box; other site 315730012901 G3 box; other site 315730012902 Switch II region; other site 315730012903 G4 box; other site 315730012904 G5 box; other site 315730012905 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 315730012906 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 315730012907 hypothetical protein; Provisional; Region: PRK14553 315730012908 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 315730012909 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 315730012910 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 315730012911 homodimer interface [polypeptide binding]; other site 315730012912 oligonucleotide binding site [chemical binding]; other site 315730012913 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 315730012914 Peptidase family M50; Region: Peptidase_M50; pfam02163 315730012915 active site 315730012916 putative substrate binding region [chemical binding]; other site 315730012917 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730012918 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730012919 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 315730012920 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 315730012921 Switch I; other site 315730012922 Switch II; other site 315730012923 septum formation inhibitor; Reviewed; Region: minC; PRK00513 315730012924 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 315730012925 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 315730012926 rod shape-determining protein MreC; Provisional; Region: PRK13922 315730012927 rod shape-determining protein MreC; Region: MreC; pfam04085 315730012928 rod shape-determining protein MreB; Provisional; Region: PRK13927 315730012929 MreB and similar proteins; Region: MreB_like; cd10225 315730012930 nucleotide binding site [chemical binding]; other site 315730012931 Mg binding site [ion binding]; other site 315730012932 putative protofilament interaction site [polypeptide binding]; other site 315730012933 RodZ interaction site [polypeptide binding]; other site 315730012934 hypothetical protein; Reviewed; Region: PRK00024 315730012935 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 315730012936 MPN+ (JAMM) motif; other site 315730012937 Zinc-binding site [ion binding]; other site 315730012938 Maf-like protein; Region: Maf; pfam02545 315730012939 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 315730012940 active site 315730012941 dimer interface [polypeptide binding]; other site 315730012942 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 315730012943 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730012944 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730012945 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 315730012946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315730012947 active site 315730012948 HIGH motif; other site 315730012949 nucleotide binding site [chemical binding]; other site 315730012950 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730012951 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 315730012952 active site 315730012953 KMSKS motif; other site 315730012954 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 315730012955 tRNA binding surface [nucleotide binding]; other site 315730012956 anticodon binding site; other site 315730012957 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 315730012958 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 315730012959 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 315730012960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315730012961 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 315730012962 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730012963 inhibitor-cofactor binding pocket; inhibition site 315730012964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012965 catalytic residue [active] 315730012966 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 315730012967 dimer interface [polypeptide binding]; other site 315730012968 active site 315730012969 Schiff base residues; other site 315730012970 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 315730012971 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315730012972 active site 315730012973 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 315730012974 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 315730012975 domain interfaces; other site 315730012976 active site 315730012977 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315730012978 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 315730012979 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 315730012980 tRNA; other site 315730012981 putative tRNA binding site [nucleotide binding]; other site 315730012982 putative NADP binding site [chemical binding]; other site 315730012983 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 315730012984 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315730012985 MarR family; Region: MarR; pfam01047 315730012986 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 315730012987 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 315730012988 G1 box; other site 315730012989 GTP/Mg2+ binding site [chemical binding]; other site 315730012990 Switch I region; other site 315730012991 G2 box; other site 315730012992 G3 box; other site 315730012993 Switch II region; other site 315730012994 G4 box; other site 315730012995 G5 box; other site 315730012996 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 315730012997 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315730012998 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315730012999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730013000 Walker A motif; other site 315730013001 ATP binding site [chemical binding]; other site 315730013002 Walker B motif; other site 315730013003 arginine finger; other site 315730013004 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315730013005 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 315730013006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730013007 Walker A motif; other site 315730013008 ATP binding site [chemical binding]; other site 315730013009 Walker B motif; other site 315730013010 arginine finger; other site 315730013011 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 315730013012 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 315730013013 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 315730013014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730013015 Walker A motif; other site 315730013016 ATP binding site [chemical binding]; other site 315730013017 Walker B motif; other site 315730013018 arginine finger; other site 315730013019 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 315730013020 trigger factor; Provisional; Region: tig; PRK01490 315730013021 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 315730013022 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 315730013023 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 315730013024 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 315730013025 pentamer interface [polypeptide binding]; other site 315730013026 dodecaamer interface [polypeptide binding]; other site 315730013027 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 315730013028 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 315730013029 active site 315730013030 metal binding site [ion binding]; metal-binding site 315730013031 homotetramer interface [polypeptide binding]; other site 315730013032 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 315730013033 active site 315730013034 dimerization interface [polypeptide binding]; other site 315730013035 ribonuclease PH; Reviewed; Region: rph; PRK00173 315730013036 Ribonuclease PH; Region: RNase_PH_bact; cd11362 315730013037 hexamer interface [polypeptide binding]; other site 315730013038 active site 315730013039 Sporulation and spore germination; Region: Germane; pfam10646 315730013040 Spore germination protein [General function prediction only]; Region: COG5401 315730013041 Sporulation and spore germination; Region: Germane; pfam10646 315730013042 glutamate racemase; Provisional; Region: PRK00865 315730013043 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730013044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730013045 DNA binding residues [nucleotide binding] 315730013046 dimerization interface [polypeptide binding]; other site 315730013047 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730013048 putative deaminase; Validated; Region: PRK06846 315730013049 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 315730013050 active site 315730013051 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 315730013052 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730013053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730013054 non-specific DNA binding site [nucleotide binding]; other site 315730013055 salt bridge; other site 315730013056 sequence-specific DNA binding site [nucleotide binding]; other site 315730013057 Cupin domain; Region: Cupin_2; pfam07883 315730013058 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 315730013059 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 315730013060 amphipathic channel; other site 315730013061 Asn-Pro-Ala signature motifs; other site 315730013062 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730013063 Transcriptional regulator; Region: Rrf2; pfam02082 315730013064 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315730013065 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 315730013066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730013067 Walker A/P-loop; other site 315730013068 ATP binding site [chemical binding]; other site 315730013069 Q-loop/lid; other site 315730013070 ABC transporter signature motif; other site 315730013071 Walker B; other site 315730013072 D-loop; other site 315730013073 H-loop/switch region; other site 315730013074 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 315730013075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730013076 active site 315730013077 motif I; other site 315730013078 motif II; other site 315730013079 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 315730013080 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 315730013081 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315730013082 ligand binding site [chemical binding]; other site 315730013083 flagellar motor protein MotA; Validated; Region: PRK08124 315730013084 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315730013085 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730013086 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315730013087 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315730013088 active site 315730013089 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 315730013090 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 315730013091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730013092 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 315730013093 L-aspartate oxidase; Provisional; Region: PRK06175 315730013094 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315730013095 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 315730013096 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 315730013097 putative Iron-sulfur protein interface [polypeptide binding]; other site 315730013098 proximal heme binding site [chemical binding]; other site 315730013099 distal heme binding site [chemical binding]; other site 315730013100 putative dimer interface [polypeptide binding]; other site 315730013101 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 315730013102 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 315730013103 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730013104 GIY-YIG motif/motif A; other site 315730013105 active site 315730013106 catalytic site [active] 315730013107 putative DNA binding site [nucleotide binding]; other site 315730013108 metal binding site [ion binding]; metal-binding site 315730013109 UvrB/uvrC motif; Region: UVR; pfam02151 315730013110 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 315730013111 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730013112 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 315730013113 catalytic residues [active] 315730013114 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 315730013115 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 315730013116 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 315730013117 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 315730013118 Ligand binding site [chemical binding]; other site 315730013119 Electron transfer flavoprotein domain; Region: ETF; pfam01012 315730013120 enoyl-CoA hydratase; Provisional; Region: PRK07658 315730013121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730013122 substrate binding site [chemical binding]; other site 315730013123 oxyanion hole (OAH) forming residues; other site 315730013124 trimer interface [polypeptide binding]; other site 315730013125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 315730013126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730013127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730013128 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315730013129 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 315730013130 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 315730013131 acyl-activating enzyme (AAE) consensus motif; other site 315730013132 putative AMP binding site [chemical binding]; other site 315730013133 putative active site [active] 315730013134 putative CoA binding site [chemical binding]; other site 315730013135 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 315730013136 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730013137 siderophore binding site; other site 315730013138 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730013139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730013140 ABC-ATPase subunit interface; other site 315730013141 dimer interface [polypeptide binding]; other site 315730013142 putative PBP binding regions; other site 315730013143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730013144 ABC-ATPase subunit interface; other site 315730013145 dimer interface [polypeptide binding]; other site 315730013146 putative PBP binding regions; other site 315730013147 DinB family; Region: DinB; pfam05163 315730013148 DinB superfamily; Region: DinB_2; pfam12867 315730013149 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730013150 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 315730013151 Walker A/P-loop; other site 315730013152 ATP binding site [chemical binding]; other site 315730013153 Q-loop/lid; other site 315730013154 ABC transporter signature motif; other site 315730013155 Walker B; other site 315730013156 D-loop; other site 315730013157 H-loop/switch region; other site 315730013158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013160 dimer interface [polypeptide binding]; other site 315730013161 phosphorylation site [posttranslational modification] 315730013162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013163 ATP binding site [chemical binding]; other site 315730013164 Mg2+ binding site [ion binding]; other site 315730013165 G-X-G motif; other site 315730013166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013168 active site 315730013169 phosphorylation site [posttranslational modification] 315730013170 intermolecular recognition site; other site 315730013171 dimerization interface [polypeptide binding]; other site 315730013172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013173 DNA binding site [nucleotide binding] 315730013174 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 315730013175 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 315730013176 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 315730013177 putative RNA binding site [nucleotide binding]; other site 315730013178 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 315730013179 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730013180 TrkA-N domain; Region: TrkA_N; pfam02254 315730013181 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 315730013182 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 315730013183 active site 315730013184 catalytic site [active] 315730013185 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730013186 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730013187 Walker A/P-loop; other site 315730013188 ATP binding site [chemical binding]; other site 315730013189 Q-loop/lid; other site 315730013190 ABC transporter signature motif; other site 315730013191 Walker B; other site 315730013192 D-loop; other site 315730013193 H-loop/switch region; other site 315730013194 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730013195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730013196 ABC-ATPase subunit interface; other site 315730013197 dimer interface [polypeptide binding]; other site 315730013198 putative PBP binding regions; other site 315730013199 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 315730013200 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730013201 intersubunit interface [polypeptide binding]; other site 315730013202 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013203 heme-binding site [chemical binding]; other site 315730013204 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013205 heme-binding site [chemical binding]; other site 315730013206 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013207 heme-binding site [chemical binding]; other site 315730013208 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013209 heme-binding site [chemical binding]; other site 315730013210 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013211 heme-binding site [chemical binding]; other site 315730013212 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013213 heme-binding site [chemical binding]; other site 315730013214 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013215 heme-binding site [chemical binding]; other site 315730013216 heme uptake protein IsdC; Region: IsdC; TIGR03656 315730013217 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730013218 heme-binding site [chemical binding]; other site 315730013219 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 315730013220 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730013221 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730013222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013223 RNA binding surface [nucleotide binding]; other site 315730013224 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 315730013225 probable active site [active] 315730013226 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 315730013227 MutS domain III; Region: MutS_III; pfam05192 315730013228 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 315730013229 Walker A/P-loop; other site 315730013230 ATP binding site [chemical binding]; other site 315730013231 Q-loop/lid; other site 315730013232 ABC transporter signature motif; other site 315730013233 Walker B; other site 315730013234 D-loop; other site 315730013235 H-loop/switch region; other site 315730013236 Smr domain; Region: Smr; pfam01713 315730013237 hypothetical protein; Provisional; Region: PRK08609 315730013238 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 315730013239 active site 315730013240 primer binding site [nucleotide binding]; other site 315730013241 NTP binding site [chemical binding]; other site 315730013242 metal binding triad [ion binding]; metal-binding site 315730013243 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 315730013244 active site 315730013245 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 315730013246 Colicin V production protein; Region: Colicin_V; pfam02674 315730013247 cell division protein ZapA; Provisional; Region: PRK14126 315730013248 ribonuclease HIII; Provisional; Region: PRK00996 315730013249 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 315730013250 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 315730013251 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730013252 active site 315730013253 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315730013254 HSP70 interaction site [polypeptide binding]; other site 315730013255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730013256 TPR motif; other site 315730013257 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730013258 binding surface 315730013259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730013260 binding surface 315730013261 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730013262 TPR motif; other site 315730013263 Tetratricopeptide repeat; Region: TPR_9; pfam13371 315730013264 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 315730013265 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315730013266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 315730013267 nucleotide binding site [chemical binding]; other site 315730013268 GrpE; Region: GrpE; pfam01025 315730013269 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315730013270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730013271 Walker A motif; other site 315730013272 ATP binding site [chemical binding]; other site 315730013273 Walker B motif; other site 315730013274 arginine finger; other site 315730013275 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 315730013276 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 315730013277 putative dimer interface [polypeptide binding]; other site 315730013278 putative anticodon binding site; other site 315730013279 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315730013280 homodimer interface [polypeptide binding]; other site 315730013281 motif 1; other site 315730013282 motif 2; other site 315730013283 active site 315730013284 motif 3; other site 315730013285 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 315730013286 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315730013287 putative tRNA-binding site [nucleotide binding]; other site 315730013288 B3/4 domain; Region: B3_4; pfam03483 315730013289 tRNA synthetase B5 domain; Region: B5; smart00874 315730013290 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 315730013291 dimer interface [polypeptide binding]; other site 315730013292 motif 1; other site 315730013293 motif 3; other site 315730013294 motif 2; other site 315730013295 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 315730013296 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 315730013297 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 315730013298 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 315730013299 dimer interface [polypeptide binding]; other site 315730013300 motif 1; other site 315730013301 active site 315730013302 motif 2; other site 315730013303 motif 3; other site 315730013304 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 315730013305 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 315730013306 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 315730013307 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 315730013308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730013309 Zn2+ binding site [ion binding]; other site 315730013310 Mg2+ binding site [ion binding]; other site 315730013311 CAAX protease self-immunity; Region: Abi; pfam02517 315730013312 ComEC family competence protein; Provisional; Region: PRK11539 315730013313 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730013314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013315 putative substrate translocation pore; other site 315730013316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013317 HlyD family secretion protein; Region: HlyD_3; pfam13437 315730013318 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 315730013319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730013320 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730013321 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730013322 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315730013323 oligomer interface [polypeptide binding]; other site 315730013324 active site 315730013325 metal binding site [ion binding]; metal-binding site 315730013326 dUTPase; Region: dUTPase_2; pfam08761 315730013327 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 315730013328 active site 315730013329 homodimer interface [polypeptide binding]; other site 315730013330 metal binding site [ion binding]; metal-binding site 315730013331 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 315730013332 23S rRNA binding site [nucleotide binding]; other site 315730013333 L21 binding site [polypeptide binding]; other site 315730013334 L13 binding site [polypeptide binding]; other site 315730013335 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 315730013336 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 315730013337 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 315730013338 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 315730013339 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 315730013340 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315730013341 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 315730013342 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315730013343 active site 315730013344 dimer interface [polypeptide binding]; other site 315730013345 motif 1; other site 315730013346 motif 2; other site 315730013347 motif 3; other site 315730013348 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315730013349 anticodon binding site; other site 315730013350 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 315730013351 primosomal protein DnaI; Reviewed; Region: PRK08939 315730013352 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 315730013353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730013354 Walker A motif; other site 315730013355 ATP binding site [chemical binding]; other site 315730013356 Walker B motif; other site 315730013357 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 315730013358 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 315730013359 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 315730013360 ATP cone domain; Region: ATP-cone; pfam03477 315730013361 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 315730013362 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 315730013363 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 315730013364 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 315730013365 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 315730013366 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 315730013367 CoA-binding site [chemical binding]; other site 315730013368 ATP-binding [chemical binding]; other site 315730013369 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315730013370 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 315730013371 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 315730013372 DNA binding site [nucleotide binding] 315730013373 catalytic residue [active] 315730013374 H2TH interface [polypeptide binding]; other site 315730013375 putative catalytic residues [active] 315730013376 turnover-facilitating residue; other site 315730013377 intercalation triad [nucleotide binding]; other site 315730013378 8OG recognition residue [nucleotide binding]; other site 315730013379 putative reading head residues; other site 315730013380 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 315730013381 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315730013382 DNA polymerase I; Provisional; Region: PRK05755 315730013383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315730013384 active site 315730013385 metal binding site 1 [ion binding]; metal-binding site 315730013386 putative 5' ssDNA interaction site; other site 315730013387 metal binding site 3; metal-binding site 315730013388 metal binding site 2 [ion binding]; metal-binding site 315730013389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315730013390 putative DNA binding site [nucleotide binding]; other site 315730013391 putative metal binding site [ion binding]; other site 315730013392 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 315730013393 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 315730013394 active site 315730013395 DNA binding site [nucleotide binding] 315730013396 catalytic site [active] 315730013397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013398 dimerization interface [polypeptide binding]; other site 315730013399 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730013400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730013401 putative active site [active] 315730013402 heme pocket [chemical binding]; other site 315730013403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013404 dimer interface [polypeptide binding]; other site 315730013405 phosphorylation site [posttranslational modification] 315730013406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013407 ATP binding site [chemical binding]; other site 315730013408 Mg2+ binding site [ion binding]; other site 315730013409 G-X-G motif; other site 315730013410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013412 active site 315730013413 phosphorylation site [posttranslational modification] 315730013414 intermolecular recognition site; other site 315730013415 dimerization interface [polypeptide binding]; other site 315730013416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013417 DNA binding site [nucleotide binding] 315730013418 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315730013419 active site 2 [active] 315730013420 active site 1 [active] 315730013421 malate dehydrogenase; Reviewed; Region: PRK06223 315730013422 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 315730013423 NAD(P) binding site [chemical binding]; other site 315730013424 dimer interface [polypeptide binding]; other site 315730013425 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730013426 substrate binding site [chemical binding]; other site 315730013427 isocitrate dehydrogenase; Reviewed; Region: PRK07006 315730013428 isocitrate dehydrogenase; Validated; Region: PRK07362 315730013429 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 315730013430 dimer interface [polypeptide binding]; other site 315730013431 Citrate synthase; Region: Citrate_synt; pfam00285 315730013432 active site 315730013433 citrylCoA binding site [chemical binding]; other site 315730013434 oxalacetate/citrate binding site [chemical binding]; other site 315730013435 coenzyme A binding site [chemical binding]; other site 315730013436 catalytic triad [active] 315730013437 Protein of unknown function (DUF441); Region: DUF441; pfam04284 315730013438 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 315730013439 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730013440 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 315730013441 pyruvate kinase; Provisional; Region: PRK06354 315730013442 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 315730013443 domain interfaces; other site 315730013444 active site 315730013445 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 315730013446 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 315730013447 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 315730013448 active site 315730013449 ADP/pyrophosphate binding site [chemical binding]; other site 315730013450 dimerization interface [polypeptide binding]; other site 315730013451 allosteric effector site; other site 315730013452 fructose-1,6-bisphosphate binding site; other site 315730013453 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 315730013454 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315730013455 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 315730013456 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 315730013457 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 315730013458 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315730013459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730013460 DNA-binding site [nucleotide binding]; DNA binding site 315730013461 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315730013462 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730013463 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315730013464 putative NAD(P) binding site [chemical binding]; other site 315730013465 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 315730013466 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 315730013467 active site 315730013468 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 315730013469 generic binding surface II; other site 315730013470 generic binding surface I; other site 315730013471 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 315730013472 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 315730013473 DHH family; Region: DHH; pfam01368 315730013474 DHHA1 domain; Region: DHHA1; pfam02272 315730013475 YtpI-like protein; Region: YtpI; pfam14007 315730013476 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 315730013477 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 315730013478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730013479 DNA-binding site [nucleotide binding]; DNA binding site 315730013480 DRTGG domain; Region: DRTGG; pfam07085 315730013481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 315730013482 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 315730013483 active site 2 [active] 315730013484 active site 1 [active] 315730013485 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 315730013486 metal-dependent hydrolase; Provisional; Region: PRK00685 315730013487 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730013488 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730013489 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730013490 active site 315730013491 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730013492 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730013493 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730013494 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730013495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 315730013496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730013497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730013498 Coenzyme A binding pocket [chemical binding]; other site 315730013499 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 315730013500 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730013501 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 315730013502 hexamer interface [polypeptide binding]; other site 315730013503 ligand binding site [chemical binding]; other site 315730013504 putative active site [active] 315730013505 NAD(P) binding site [chemical binding]; other site 315730013506 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 315730013507 classical (c) SDRs; Region: SDR_c; cd05233 315730013508 NAD(P) binding site [chemical binding]; other site 315730013509 active site 315730013510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315730013511 Ligand Binding Site [chemical binding]; other site 315730013512 DinB superfamily; Region: DinB_2; pfam12867 315730013513 argininosuccinate lyase; Provisional; Region: PRK00855 315730013514 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315730013515 active sites [active] 315730013516 tetramer interface [polypeptide binding]; other site 315730013517 argininosuccinate synthase; Provisional; Region: PRK13820 315730013518 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 315730013519 ANP binding site [chemical binding]; other site 315730013520 Substrate Binding Site II [chemical binding]; other site 315730013521 Substrate Binding Site I [chemical binding]; other site 315730013522 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 315730013523 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730013524 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013525 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013526 EcsC protein family; Region: EcsC; pfam12787 315730013527 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 315730013528 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 315730013529 nudix motif; other site 315730013530 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 315730013531 propionate/acetate kinase; Provisional; Region: PRK12379 315730013532 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 315730013533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730013534 S-adenosylmethionine binding site [chemical binding]; other site 315730013535 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 315730013536 dimer interface [polypeptide binding]; other site 315730013537 catalytic triad [active] 315730013538 peroxidatic and resolving cysteines [active] 315730013539 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730013540 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 315730013541 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 315730013542 ATP-NAD kinase; Region: NAD_kinase; pfam01513 315730013543 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730013544 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730013545 active site 315730013546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730013547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730013548 dimer interface [polypeptide binding]; other site 315730013549 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315730013550 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 315730013551 active site 315730013552 acyl-activating enzyme (AAE) consensus motif; other site 315730013553 putative CoA binding site [chemical binding]; other site 315730013554 AMP binding site [chemical binding]; other site 315730013555 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730013556 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 315730013557 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 315730013558 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 315730013559 Ligand Binding Site [chemical binding]; other site 315730013560 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 315730013561 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 315730013562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730013563 catalytic residue [active] 315730013564 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 315730013565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730013566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730013567 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 315730013568 GAF domain; Region: GAF_2; pfam13185 315730013569 methionine gamma-lyase; Provisional; Region: PRK06767 315730013570 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730013571 homodimer interface [polypeptide binding]; other site 315730013572 substrate-cofactor binding pocket; other site 315730013573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730013574 catalytic residue [active] 315730013575 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 315730013576 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 315730013577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013578 RNA binding surface [nucleotide binding]; other site 315730013579 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 315730013580 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 315730013581 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 315730013582 active site 315730013583 HIGH motif; other site 315730013584 dimer interface [polypeptide binding]; other site 315730013585 KMSKS motif; other site 315730013586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013587 RNA binding surface [nucleotide binding]; other site 315730013588 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 315730013589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730013590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730013591 DNA binding residues [nucleotide binding] 315730013592 maltose O-acetyltransferase; Provisional; Region: PRK10092 315730013593 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 315730013594 active site 315730013595 substrate binding site [chemical binding]; other site 315730013596 trimer interface [polypeptide binding]; other site 315730013597 CoA binding site [chemical binding]; other site 315730013598 acetyl-CoA synthetase; Provisional; Region: PRK04319 315730013599 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315730013600 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 315730013601 active site 315730013602 acyl-activating enzyme (AAE) consensus motif; other site 315730013603 putative CoA binding site [chemical binding]; other site 315730013604 AMP binding site [chemical binding]; other site 315730013605 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 315730013606 Coenzyme A binding pocket [chemical binding]; other site 315730013607 FOG: CBS domain [General function prediction only]; Region: COG0517 315730013608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 315730013609 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 315730013610 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 315730013611 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 315730013612 active site 315730013613 Zn binding site [ion binding]; other site 315730013614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730013615 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 315730013616 active site 315730013617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315730013618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 315730013619 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 315730013620 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 315730013621 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 315730013622 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 315730013623 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 315730013624 catabolite control protein A; Region: ccpA; TIGR01481 315730013625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730013626 DNA binding site [nucleotide binding] 315730013627 domain linker motif; other site 315730013628 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 315730013629 dimerization interface [polypeptide binding]; other site 315730013630 effector binding site; other site 315730013631 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 315730013632 putative dimer interface [polypeptide binding]; other site 315730013633 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 315730013634 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 315730013635 putative dimer interface [polypeptide binding]; other site 315730013636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730013637 catalytic residues [active] 315730013638 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 315730013639 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315730013640 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 315730013641 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730013642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730013643 Coenzyme A binding pocket [chemical binding]; other site 315730013644 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730013645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730013646 Predicted transcriptional regulators [Transcription]; Region: COG1695 315730013647 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 315730013648 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 315730013649 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 315730013650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730013651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730013652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730013653 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 315730013654 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 315730013655 active site 315730013656 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315730013657 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 315730013658 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 315730013659 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730013660 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730013661 active site 315730013662 metal binding site [ion binding]; metal-binding site 315730013663 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315730013664 putative tRNA-binding site [nucleotide binding]; other site 315730013665 hypothetical protein; Provisional; Region: PRK13668 315730013666 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730013667 catalytic residues [active] 315730013668 NTPase; Reviewed; Region: PRK03114 315730013669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730013670 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315730013671 oligomer interface [polypeptide binding]; other site 315730013672 active site 315730013673 metal binding site [ion binding]; metal-binding site 315730013674 Predicted small secreted protein [Function unknown]; Region: COG5584 315730013675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730013676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730013677 S-adenosylmethionine binding site [chemical binding]; other site 315730013678 YtzH-like protein; Region: YtzH; pfam14165 315730013679 Phosphotransferase enzyme family; Region: APH; pfam01636 315730013680 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 315730013681 active site 315730013682 substrate binding site [chemical binding]; other site 315730013683 ATP binding site [chemical binding]; other site 315730013684 pullulanase, type I; Region: pulA_typeI; TIGR02104 315730013685 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 315730013686 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 315730013687 Ca binding site [ion binding]; other site 315730013688 active site 315730013689 catalytic site [active] 315730013690 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 315730013691 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730013692 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730013693 dipeptidase PepV; Reviewed; Region: PRK07318 315730013694 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 315730013695 active site 315730013696 metal binding site [ion binding]; metal-binding site 315730013697 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 315730013698 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730013699 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013700 RNA binding surface [nucleotide binding]; other site 315730013701 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 315730013702 active site 315730013703 uracil binding [chemical binding]; other site 315730013704 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730013705 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 315730013706 HI0933-like protein; Region: HI0933_like; pfam03486 315730013707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730013708 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730013709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013710 putative substrate translocation pore; other site 315730013711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730013712 dimerization interface [polypeptide binding]; other site 315730013713 putative DNA binding site [nucleotide binding]; other site 315730013714 putative Zn2+ binding site [ion binding]; other site 315730013715 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 315730013716 putative hydrophobic ligand binding site [chemical binding]; other site 315730013717 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 315730013718 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 315730013719 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 315730013720 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315730013721 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315730013722 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315730013723 NAD binding site [chemical binding]; other site 315730013724 homodimer interface [polypeptide binding]; other site 315730013725 active site 315730013726 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 315730013727 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 315730013728 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730013729 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315730013730 MoaE interaction surface [polypeptide binding]; other site 315730013731 MoeB interaction surface [polypeptide binding]; other site 315730013732 thiocarboxylated glycine; other site 315730013733 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315730013734 MoaE homodimer interface [polypeptide binding]; other site 315730013735 MoaD interaction [polypeptide binding]; other site 315730013736 active site residues [active] 315730013737 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 315730013738 Walker A motif; other site 315730013739 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315730013740 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315730013741 dimer interface [polypeptide binding]; other site 315730013742 putative functional site; other site 315730013743 putative MPT binding site; other site 315730013744 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 315730013745 trimer interface [polypeptide binding]; other site 315730013746 dimer interface [polypeptide binding]; other site 315730013747 putative active site [active] 315730013748 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 315730013749 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730013750 ATP binding site [chemical binding]; other site 315730013751 substrate interface [chemical binding]; other site 315730013752 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 315730013753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730013754 FeS/SAM binding site; other site 315730013755 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315730013756 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730013757 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730013758 active site residue [active] 315730013759 homoserine O-acetyltransferase; Provisional; Region: PRK06765 315730013760 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 315730013761 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730013762 Spore germination protein; Region: Spore_permease; pfam03845 315730013763 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 315730013764 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 315730013765 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 315730013766 putative nucleotide binding site [chemical binding]; other site 315730013767 putative metal binding site [ion binding]; other site 315730013768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730013769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730013770 Coenzyme A binding pocket [chemical binding]; other site 315730013771 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 315730013772 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315730013773 HIGH motif; other site 315730013774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730013775 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315730013776 active site 315730013777 KMSKS motif; other site 315730013778 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 315730013779 tRNA binding surface [nucleotide binding]; other site 315730013780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730013782 putative substrate translocation pore; other site 315730013783 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315730013784 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730013785 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 315730013786 TrkA-C domain; Region: TrkA_C; pfam02080 315730013787 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 315730013788 Int/Topo IB signature motif; other site 315730013789 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730013790 FtsX-like permease family; Region: FtsX; pfam02687 315730013791 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730013793 Walker A/P-loop; other site 315730013794 ATP binding site [chemical binding]; other site 315730013795 Q-loop/lid; other site 315730013796 ABC transporter signature motif; other site 315730013797 Walker B; other site 315730013798 D-loop; other site 315730013799 H-loop/switch region; other site 315730013800 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 315730013801 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 315730013802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730013803 FeS/SAM binding site; other site 315730013804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 315730013805 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 315730013806 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 315730013807 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730013808 Walker A/P-loop; other site 315730013809 ATP binding site [chemical binding]; other site 315730013810 Q-loop/lid; other site 315730013811 ABC transporter signature motif; other site 315730013812 Walker B; other site 315730013813 D-loop; other site 315730013814 H-loop/switch region; other site 315730013815 aspartate racemase; Region: asp_race; TIGR00035 315730013816 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730013817 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 315730013818 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 315730013819 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 315730013820 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 315730013821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730013822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 315730013823 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 315730013824 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 315730013825 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 315730013826 trimer interface [polypeptide binding]; other site 315730013827 putative metal binding site [ion binding]; other site 315730013828 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 315730013829 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 315730013830 active site 315730013831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730013832 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 315730013833 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 315730013834 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 315730013835 GTP binding site; other site 315730013836 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 315730013837 MPT binding site; other site 315730013838 trimer interface [polypeptide binding]; other site 315730013839 S-adenosylmethionine synthetase; Validated; Region: PRK05250 315730013840 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 315730013841 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 315730013842 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 315730013843 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 315730013844 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 315730013845 active site 315730013846 substrate-binding site [chemical binding]; other site 315730013847 metal-binding site [ion binding] 315730013848 ATP binding site [chemical binding]; other site 315730013849 ATP synthase I chain; Region: ATP_synt_I; pfam03899 315730013850 EamA-like transporter family; Region: EamA; pfam00892 315730013851 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730013852 EamA-like transporter family; Region: EamA; pfam00892 315730013853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 315730013854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013855 ATP binding site [chemical binding]; other site 315730013856 Mg2+ binding site [ion binding]; other site 315730013857 G-X-G motif; other site 315730013858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013860 dimer interface [polypeptide binding]; other site 315730013861 phosphorylation site [posttranslational modification] 315730013862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013863 ATP binding site [chemical binding]; other site 315730013864 Mg2+ binding site [ion binding]; other site 315730013865 G-X-G motif; other site 315730013866 hydroperoxidase II; Provisional; Region: katE; PRK11249 315730013867 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 315730013868 heme binding pocket [chemical binding]; other site 315730013869 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 315730013870 domain interactions; other site 315730013871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730013872 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730013873 Sulfatase; Region: Sulfatase; pfam00884 315730013874 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 315730013875 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 315730013876 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315730013877 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 315730013878 NMT1-like family; Region: NMT1_2; pfam13379 315730013879 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730013880 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 315730013881 Walker A/P-loop; other site 315730013882 ATP binding site [chemical binding]; other site 315730013883 Q-loop/lid; other site 315730013884 ABC transporter signature motif; other site 315730013885 Walker B; other site 315730013886 D-loop; other site 315730013887 H-loop/switch region; other site 315730013888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 315730013889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730013890 dimer interface [polypeptide binding]; other site 315730013891 conserved gate region; other site 315730013892 putative PBP binding loops; other site 315730013893 ABC-ATPase subunit interface; other site 315730013894 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 315730013895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730013896 motif II; other site 315730013897 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315730013898 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 315730013899 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315730013900 nudix motif; other site 315730013901 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 315730013902 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013903 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013904 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013905 S-ribosylhomocysteinase; Provisional; Region: PRK02260 315730013906 Haemolytic domain; Region: Haemolytic; pfam01809 315730013907 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315730013908 active site clefts [active] 315730013909 zinc binding site [ion binding]; other site 315730013910 dimer interface [polypeptide binding]; other site 315730013911 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 315730013912 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315730013913 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315730013914 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730013915 S-layer homology domain; Region: SLH; pfam00395 315730013916 S-layer homology domain; Region: SLH; pfam00395 315730013917 S-layer homology domain; Region: SLH; pfam00395 315730013918 Excalibur calcium-binding domain; Region: Excalibur; smart00894 315730013919 Uncharacterized conserved protein [Function unknown]; Region: COG1434 315730013920 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730013921 putative active site [active] 315730013922 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730013923 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013924 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013925 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730013926 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 315730013927 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 315730013928 Predicted membrane protein [Function unknown]; Region: COG3766 315730013929 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 315730013930 hypothetical protein; Provisional; Region: PRK12473 315730013931 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 315730013932 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 315730013933 G1 box; other site 315730013934 GTP/Mg2+ binding site [chemical binding]; other site 315730013935 Switch I region; other site 315730013936 G2 box; other site 315730013937 G3 box; other site 315730013938 Switch II region; other site 315730013939 G4 box; other site 315730013940 G5 box; other site 315730013941 Nucleoside recognition; Region: Gate; pfam07670 315730013942 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 315730013943 Nucleoside recognition; Region: Gate; pfam07670 315730013944 FeoA domain; Region: FeoA; pfam04023 315730013945 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 315730013946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013947 dimerization interface [polypeptide binding]; other site 315730013948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013949 dimer interface [polypeptide binding]; other site 315730013950 phosphorylation site [posttranslational modification] 315730013951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013952 ATP binding site [chemical binding]; other site 315730013953 Mg2+ binding site [ion binding]; other site 315730013954 G-X-G motif; other site 315730013955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013957 active site 315730013958 phosphorylation site [posttranslational modification] 315730013959 intermolecular recognition site; other site 315730013960 dimerization interface [polypeptide binding]; other site 315730013961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013962 DNA binding site [nucleotide binding] 315730013963 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315730013964 active site 315730013965 catalytic site [active] 315730013966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730013967 active site 315730013968 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 315730013969 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 315730013970 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 315730013971 Cold-inducible protein YdjO; Region: YdjO; pfam14169 315730013972 FtsX-like permease family; Region: FtsX; pfam02687 315730013973 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013974 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730013975 Walker A/P-loop; other site 315730013976 ATP binding site [chemical binding]; other site 315730013977 Q-loop/lid; other site 315730013978 ABC transporter signature motif; other site 315730013979 Walker B; other site 315730013980 D-loop; other site 315730013981 H-loop/switch region; other site 315730013982 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730013983 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730013984 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730013985 NodB motif; other site 315730013986 active site 315730013987 catalytic site [active] 315730013988 Zn binding site [ion binding]; other site 315730013989 FtsX-like permease family; Region: FtsX; pfam02687 315730013990 rod shape-determining protein MreC; Provisional; Region: PRK13922 315730013991 rod shape-determining protein MreC; Region: MreC; pfam04085 315730013992 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730013993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013995 dimerization interface [polypeptide binding]; other site 315730013996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013997 dimer interface [polypeptide binding]; other site 315730013998 phosphorylation site [posttranslational modification] 315730013999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014000 ATP binding site [chemical binding]; other site 315730014001 Mg2+ binding site [ion binding]; other site 315730014002 G-X-G motif; other site 315730014003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014005 active site 315730014006 phosphorylation site [posttranslational modification] 315730014007 intermolecular recognition site; other site 315730014008 dimerization interface [polypeptide binding]; other site 315730014009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014010 DNA binding site [nucleotide binding] 315730014011 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730014012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 315730014013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730014014 S-adenosylmethionine binding site [chemical binding]; other site 315730014015 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730014016 FtsX-like permease family; Region: FtsX; pfam02687 315730014017 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730014018 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730014019 Walker A/P-loop; other site 315730014020 ATP binding site [chemical binding]; other site 315730014021 Q-loop/lid; other site 315730014022 ABC transporter signature motif; other site 315730014023 Walker B; other site 315730014024 D-loop; other site 315730014025 H-loop/switch region; other site 315730014026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730014027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730014028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 315730014029 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730014030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730014031 Walker A/P-loop; other site 315730014032 ATP binding site [chemical binding]; other site 315730014033 Q-loop/lid; other site 315730014034 ABC transporter signature motif; other site 315730014035 Walker B; other site 315730014036 D-loop; other site 315730014037 H-loop/switch region; other site 315730014038 Predicted integral membrane protein [Function unknown]; Region: COG5658 315730014039 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 315730014040 SdpI/YhfL protein family; Region: SdpI; pfam13630 315730014041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730014042 dimerization interface [polypeptide binding]; other site 315730014043 putative DNA binding site [nucleotide binding]; other site 315730014044 putative Zn2+ binding site [ion binding]; other site 315730014045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014047 active site 315730014048 phosphorylation site [posttranslational modification] 315730014049 intermolecular recognition site; other site 315730014050 dimerization interface [polypeptide binding]; other site 315730014051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014052 DNA binding site [nucleotide binding] 315730014053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730014054 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 315730014055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014056 ATP binding site [chemical binding]; other site 315730014057 Mg2+ binding site [ion binding]; other site 315730014058 G-X-G motif; other site 315730014059 FtsX-like permease family; Region: FtsX; pfam02687 315730014060 FtsX-like permease family; Region: FtsX; pfam02687 315730014061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730014062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730014063 Walker A/P-loop; other site 315730014064 ATP binding site [chemical binding]; other site 315730014065 Q-loop/lid; other site 315730014066 ABC transporter signature motif; other site 315730014067 Walker B; other site 315730014068 D-loop; other site 315730014069 H-loop/switch region; other site 315730014070 fructuronate transporter; Provisional; Region: PRK10034; cl15264 315730014071 GntP family permease; Region: GntP_permease; pfam02447 315730014072 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730014073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730014074 DNA-binding site [nucleotide binding]; DNA binding site 315730014075 UTRA domain; Region: UTRA; pfam07702 315730014076 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315730014077 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 315730014078 substrate binding site [chemical binding]; other site 315730014079 ATP binding site [chemical binding]; other site 315730014080 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 315730014081 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730014082 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730014083 catalytic residue [active] 315730014084 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 315730014085 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 315730014086 active site 315730014087 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730014088 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 315730014089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730014090 HAMP domain; Region: HAMP; pfam00672 315730014091 dimerization interface [polypeptide binding]; other site 315730014092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730014093 dimer interface [polypeptide binding]; other site 315730014094 phosphorylation site [posttranslational modification] 315730014095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014096 ATP binding site [chemical binding]; other site 315730014097 Mg2+ binding site [ion binding]; other site 315730014098 G-X-G motif; other site 315730014099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014101 active site 315730014102 phosphorylation site [posttranslational modification] 315730014103 intermolecular recognition site; other site 315730014104 dimerization interface [polypeptide binding]; other site 315730014105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014106 DNA binding site [nucleotide binding] 315730014107 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 315730014108 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 315730014109 active site 315730014110 octamer interface [polypeptide binding]; other site 315730014111 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 315730014112 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 315730014113 acyl-activating enzyme (AAE) consensus motif; other site 315730014114 putative active site [active] 315730014115 putative AMP binding site [chemical binding]; other site 315730014116 putative CoA binding site [chemical binding]; other site 315730014117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730014118 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 315730014119 substrate binding site [chemical binding]; other site 315730014120 oxyanion hole (OAH) forming residues; other site 315730014121 trimer interface [polypeptide binding]; other site 315730014122 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 315730014123 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 315730014124 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 315730014125 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 315730014126 dimer interface [polypeptide binding]; other site 315730014127 tetramer interface [polypeptide binding]; other site 315730014128 PYR/PP interface [polypeptide binding]; other site 315730014129 TPP binding site [chemical binding]; other site 315730014130 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 315730014131 TPP-binding site; other site 315730014132 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 315730014133 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315730014134 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 315730014135 UbiA prenyltransferase family; Region: UbiA; pfam01040 315730014136 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 315730014137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730014138 DNA-binding site [nucleotide binding]; DNA binding site 315730014139 RNA-binding motif; other site 315730014140 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 315730014141 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730014142 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730014143 DNA binding residues [nucleotide binding] 315730014144 dimer interface [polypeptide binding]; other site 315730014145 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730014146 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 315730014147 active site flap/lid [active] 315730014148 nucleophilic elbow; other site 315730014149 catalytic triad [active] 315730014150 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 315730014151 homodimer interface [polypeptide binding]; other site 315730014152 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 315730014153 active site pocket [active] 315730014154 glycogen synthase; Provisional; Region: glgA; PRK00654 315730014155 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 315730014156 ADP-binding pocket [chemical binding]; other site 315730014157 homodimer interface [polypeptide binding]; other site 315730014158 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 315730014159 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 315730014160 ligand binding site; other site 315730014161 oligomer interface; other site 315730014162 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 315730014163 dimer interface [polypeptide binding]; other site 315730014164 N-terminal domain interface [polypeptide binding]; other site 315730014165 sulfate 1 binding site; other site 315730014166 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 315730014167 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 315730014168 ligand binding site; other site 315730014169 oligomer interface; other site 315730014170 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 315730014171 dimer interface [polypeptide binding]; other site 315730014172 N-terminal domain interface [polypeptide binding]; other site 315730014173 sulfate 1 binding site; other site 315730014174 glycogen branching enzyme; Provisional; Region: PRK12313 315730014175 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 315730014176 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 315730014177 active site 315730014178 catalytic site [active] 315730014179 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 315730014180 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730014181 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730014182 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730014183 NAD binding site [chemical binding]; other site 315730014184 dimer interface [polypeptide binding]; other site 315730014185 substrate binding site [chemical binding]; other site 315730014186 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730014187 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315730014188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730014189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730014190 DNA binding residues [nucleotide binding] 315730014191 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 315730014192 MgtC family; Region: MgtC; pfam02308 315730014193 Ion channel; Region: Ion_trans_2; pfam07885 315730014194 TrkA-N domain; Region: TrkA_N; pfam02254 315730014195 YugN-like family; Region: YugN; pfam08868 315730014196 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 315730014197 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 315730014198 active site 315730014199 dimer interface [polypeptide binding]; other site 315730014200 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 315730014201 dimer interface [polypeptide binding]; other site 315730014202 active site 315730014203 Domain of unknown function (DUF378); Region: DUF378; pfam04070 315730014204 general stress protein 13; Validated; Region: PRK08059 315730014205 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730014206 RNA binding site [nucleotide binding]; other site 315730014207 hypothetical protein; Validated; Region: PRK07682 315730014208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730014209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730014210 homodimer interface [polypeptide binding]; other site 315730014211 catalytic residue [active] 315730014212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730014213 AsnC family; Region: AsnC_trans_reg; pfam01037 315730014214 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 315730014215 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 315730014216 dimerization interface [polypeptide binding]; other site 315730014217 ligand binding site [chemical binding]; other site 315730014218 NADP binding site [chemical binding]; other site 315730014219 catalytic site [active] 315730014220 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 315730014221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730014222 nucleophilic elbow; other site 315730014223 catalytic triad; other site 315730014224 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 315730014225 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 315730014226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730014227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730014228 homodimer interface [polypeptide binding]; other site 315730014229 catalytic residue [active] 315730014230 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 315730014231 E-class dimer interface [polypeptide binding]; other site 315730014232 P-class dimer interface [polypeptide binding]; other site 315730014233 active site 315730014234 Cu2+ binding site [ion binding]; other site 315730014235 Zn2+ binding site [ion binding]; other site 315730014236 Kinase associated protein B; Region: KapB; pfam08810 315730014237 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315730014238 active site 315730014239 catalytic site [active] 315730014240 substrate binding site [chemical binding]; other site 315730014241 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 315730014242 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 315730014243 transmembrane helices; other site 315730014244 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 315730014245 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 315730014246 active site 315730014247 glycyl-tRNA synthetase; Provisional; Region: PRK04173 315730014248 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 315730014249 motif 1; other site 315730014250 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 315730014251 active site 315730014252 motif 2; other site 315730014253 motif 3; other site 315730014254 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 315730014255 anticodon binding site; other site 315730014256 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 315730014257 CoenzymeA binding site [chemical binding]; other site 315730014258 subunit interaction site [polypeptide binding]; other site 315730014259 PHB binding site; other site 315730014260 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315730014261 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315730014262 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 315730014263 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315730014264 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 315730014265 active site 315730014266 tetramer interface; other site 315730014267 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 315730014268 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 315730014269 active site 315730014270 substrate binding site [chemical binding]; other site 315730014271 metal binding site [ion binding]; metal-binding site 315730014272 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 315730014273 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315730014274 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730014275 multifunctional aminopeptidase A; Provisional; Region: PRK00913 315730014276 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 315730014277 interface (dimer of trimers) [polypeptide binding]; other site 315730014278 Substrate-binding/catalytic site; other site 315730014279 Zn-binding sites [ion binding]; other site 315730014280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315730014281 Putative membrane protein; Region: YuiB; pfam14068 315730014282 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730014283 nudix motif; other site 315730014284 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730014285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730014286 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730014287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730014288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 315730014289 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730014290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014291 putative substrate translocation pore; other site 315730014292 Helix-turn-helix domain; Region: HTH_36; pfam13730 315730014293 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730014294 Uncharacterized conserved protein [Function unknown]; Region: COG1683 315730014295 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730014296 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 315730014297 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 315730014298 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315730014299 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315730014300 hypothetical protein; Provisional; Region: PRK13669 315730014301 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730014302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730014303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730014304 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 315730014305 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 315730014306 Walker A/P-loop; other site 315730014307 ATP binding site [chemical binding]; other site 315730014308 Q-loop/lid; other site 315730014309 ABC transporter signature motif; other site 315730014310 Walker B; other site 315730014311 D-loop; other site 315730014312 H-loop/switch region; other site 315730014313 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 315730014314 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 315730014315 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 315730014316 PhnA protein; Region: PhnA; pfam03831 315730014317 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 315730014318 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 315730014319 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 315730014320 CAAX protease self-immunity; Region: Abi; pfam02517 315730014321 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 315730014322 metal binding triad [ion binding]; metal-binding site 315730014323 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 315730014324 NifU-like domain; Region: NifU; pfam01106 315730014325 spore coat protein YutH; Region: spore_yutH; TIGR02905 315730014326 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315730014327 tetramer interfaces [polypeptide binding]; other site 315730014328 binuclear metal-binding site [ion binding]; other site 315730014329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 315730014330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730014331 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730014332 FtsX-like permease family; Region: FtsX; pfam02687 315730014333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730014334 FtsX-like permease family; Region: FtsX; pfam02687 315730014335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730014336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730014337 Walker A/P-loop; other site 315730014338 ATP binding site [chemical binding]; other site 315730014339 Q-loop/lid; other site 315730014340 ABC transporter signature motif; other site 315730014341 Walker B; other site 315730014342 D-loop; other site 315730014343 H-loop/switch region; other site 315730014344 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 315730014345 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730014346 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 315730014347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014348 active site 315730014349 motif I; other site 315730014350 motif II; other site 315730014351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014352 Predicted transcriptional regulator [Transcription]; Region: COG2345 315730014353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730014354 putative DNA binding site [nucleotide binding]; other site 315730014355 putative Zn2+ binding site [ion binding]; other site 315730014356 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 315730014357 Uncharacterized conserved protein [Function unknown]; Region: COG2445 315730014358 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315730014359 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 315730014360 putative active site [active] 315730014361 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730014362 Transposase IS200 like; Region: Y1_Tnp; cl00848 315730014363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730014364 Probable transposase; Region: OrfB_IS605; pfam01385 315730014365 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 315730014366 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 315730014367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730014368 RNA binding surface [nucleotide binding]; other site 315730014369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730014370 Coenzyme A binding pocket [chemical binding]; other site 315730014371 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 315730014372 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730014373 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730014374 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730014375 DNA binding residues [nucleotide binding] 315730014376 dimer interface [polypeptide binding]; other site 315730014377 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730014378 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 315730014379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730014380 catalytic core [active] 315730014381 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 315730014382 putative deacylase active site [active] 315730014383 lipoyl synthase; Provisional; Region: PRK05481 315730014384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730014385 FeS/SAM binding site; other site 315730014386 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730014387 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730014388 sporulation protein YunB; Region: spo_yunB; TIGR02832 315730014389 Uncharacterized conserved protein [Function unknown]; Region: COG3377 315730014390 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730014391 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 315730014392 active site 315730014393 metal binding site [ion binding]; metal-binding site 315730014394 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730014395 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 315730014396 FeS assembly protein SufB; Region: sufB; TIGR01980 315730014397 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 315730014398 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 315730014399 trimerization site [polypeptide binding]; other site 315730014400 active site 315730014401 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315730014402 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 315730014403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730014404 catalytic residue [active] 315730014405 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 315730014406 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 315730014407 FeS assembly protein SufD; Region: sufD; TIGR01981 315730014408 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 315730014409 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 315730014410 Walker A/P-loop; other site 315730014411 ATP binding site [chemical binding]; other site 315730014412 Q-loop/lid; other site 315730014413 ABC transporter signature motif; other site 315730014414 Walker B; other site 315730014415 D-loop; other site 315730014416 H-loop/switch region; other site 315730014417 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 315730014418 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 315730014419 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 315730014420 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 315730014421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730014422 ABC-ATPase subunit interface; other site 315730014423 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 315730014424 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 315730014425 Walker A/P-loop; other site 315730014426 ATP binding site [chemical binding]; other site 315730014427 Q-loop/lid; other site 315730014428 ABC transporter signature motif; other site 315730014429 Walker B; other site 315730014430 D-loop; other site 315730014431 H-loop/switch region; other site 315730014432 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 315730014433 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730014434 catalytic residues [active] 315730014435 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315730014436 putative active site [active] 315730014437 putative metal binding site [ion binding]; other site 315730014438 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 315730014439 lipoyl attachment site [posttranslational modification]; other site 315730014440 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 315730014441 ArsC family; Region: ArsC; pfam03960 315730014442 putative ArsC-like catalytic residues; other site 315730014443 putative TRX-like catalytic residues [active] 315730014444 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 315730014445 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 315730014446 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 315730014447 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 315730014448 active site 315730014449 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 315730014450 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315730014451 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730014452 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730014453 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730014454 NAD binding site [chemical binding]; other site 315730014455 dimer interface [polypeptide binding]; other site 315730014456 substrate binding site [chemical binding]; other site 315730014457 Coat F domain; Region: Coat_F; pfam07875 315730014458 CAAX protease self-immunity; Region: Abi; pfam02517 315730014459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730014460 WHG domain; Region: WHG; pfam13305 315730014461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 315730014462 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730014463 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730014464 active site 315730014465 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 315730014466 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730014467 dimer interface [polypeptide binding]; other site 315730014468 active site 315730014469 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315730014470 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 315730014471 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730014472 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730014473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730014474 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 315730014475 substrate binding site [chemical binding]; other site 315730014476 oxyanion hole (OAH) forming residues; other site 315730014477 YuzL-like protein; Region: YuzL; pfam14115 315730014478 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730014479 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730014480 Proline dehydrogenase; Region: Pro_dh; cl03282 315730014481 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 315730014482 Domain of unknown function DUF77; Region: DUF77; pfam01910 315730014483 Cache domain; Region: Cache_1; pfam02743 315730014484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730014485 dimerization interface [polypeptide binding]; other site 315730014486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014487 dimer interface [polypeptide binding]; other site 315730014488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730014489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014490 dimer interface [polypeptide binding]; other site 315730014491 putative CheW interface [polypeptide binding]; other site 315730014492 Predicted transcriptional regulators [Transcription]; Region: COG1378 315730014493 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 315730014494 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730014495 C-terminal domain interface [polypeptide binding]; other site 315730014496 sugar binding site [chemical binding]; other site 315730014497 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730014498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014499 putative substrate translocation pore; other site 315730014500 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 315730014501 Spore germination protein; Region: Spore_permease; cl17796 315730014502 MAEBL; Provisional; Region: PTZ00121 315730014503 OxaA-like protein precursor; Validated; Region: PRK01622 315730014504 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730014505 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730014506 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 315730014507 hypothetical protein; Provisional; Region: PRK06758 315730014508 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 315730014509 active site 315730014510 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 315730014511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730014512 non-specific DNA binding site [nucleotide binding]; other site 315730014513 salt bridge; other site 315730014514 sequence-specific DNA binding site [nucleotide binding]; other site 315730014515 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730014516 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730014517 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 315730014518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 315730014519 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 315730014520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014522 active site 315730014523 phosphorylation site [posttranslational modification] 315730014524 intermolecular recognition site; other site 315730014525 dimerization interface [polypeptide binding]; other site 315730014526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014527 DNA binding site [nucleotide binding] 315730014528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730014529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730014530 dimer interface [polypeptide binding]; other site 315730014531 phosphorylation site [posttranslational modification] 315730014532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014533 ATP binding site [chemical binding]; other site 315730014534 Mg2+ binding site [ion binding]; other site 315730014535 G-X-G motif; other site 315730014536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730014537 EamA-like transporter family; Region: EamA; pfam00892 315730014538 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 315730014539 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315730014540 active site 315730014541 HIGH motif; other site 315730014542 KMSKS motif; other site 315730014543 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315730014544 tRNA binding surface [nucleotide binding]; other site 315730014545 anticodon binding site; other site 315730014546 Methyltransferase domain; Region: Methyltransf_23; pfam13489 315730014547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730014548 S-adenosylmethionine binding site [chemical binding]; other site 315730014549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730014550 dimerization interface [polypeptide binding]; other site 315730014551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014552 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730014553 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014554 dimer interface [polypeptide binding]; other site 315730014555 putative CheW interface [polypeptide binding]; other site 315730014556 CHASE3 domain; Region: CHASE3; cl05000 315730014557 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730014558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730014559 dimerization interface [polypeptide binding]; other site 315730014560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014561 dimer interface [polypeptide binding]; other site 315730014562 putative CheW interface [polypeptide binding]; other site 315730014563 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 315730014564 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730014565 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730014566 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 315730014567 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730014568 active site 315730014569 Zn binding site [ion binding]; other site 315730014570 Pirin-related protein [General function prediction only]; Region: COG1741 315730014571 Pirin; Region: Pirin; pfam02678 315730014572 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730014573 MarR family; Region: MarR_2; pfam12802 315730014574 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 315730014575 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 315730014576 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730014577 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 315730014578 TrkA-C domain; Region: TrkA_C; pfam02080 315730014579 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730014580 amino acid carrier protein; Region: agcS; TIGR00835 315730014581 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 315730014582 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315730014583 dimerization interface [polypeptide binding]; other site 315730014584 DPS ferroxidase diiron center [ion binding]; other site 315730014585 ion pore; other site 315730014586 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 315730014587 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 315730014588 metal binding site [ion binding]; metal-binding site 315730014589 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 315730014590 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 315730014591 Ferritin-like domain; Region: Ferritin; pfam00210 315730014592 ferroxidase diiron center [ion binding]; other site 315730014593 Predicted membrane protein [Function unknown]; Region: COG2311 315730014594 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730014595 Protein of unknown function (DUF418); Region: DUF418; pfam04235 315730014596 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730014597 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730014598 Nucleoside recognition; Region: Gate; pfam07670 315730014599 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730014600 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730014601 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730014602 Nucleoside recognition; Region: Gate; pfam07670 315730014603 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730014604 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730014605 amino acid carrier protein; Region: agcS; TIGR00835 315730014606 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730014607 amino acid carrier protein; Region: agcS; TIGR00835 315730014608 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315730014609 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730014610 NAD binding site [chemical binding]; other site 315730014611 substrate binding site [chemical binding]; other site 315730014612 putative active site [active] 315730014613 Peptidase M60-like family; Region: M60-like; pfam13402 315730014614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730014615 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730014616 Coenzyme A binding pocket [chemical binding]; other site 315730014617 TMPIT-like protein; Region: TMPIT; pfam07851 315730014618 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 315730014619 TQXA domain; Region: TQXA_dom; TIGR03934 315730014620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730014621 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730014622 active site 315730014623 catalytic tetrad [active] 315730014624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730014625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014626 putative substrate translocation pore; other site 315730014627 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730014628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730014629 dimerization interface [polypeptide binding]; other site 315730014630 putative DNA binding site [nucleotide binding]; other site 315730014631 putative Zn2+ binding site [ion binding]; other site 315730014632 Uncharacterized conserved protein [Function unknown]; Region: COG2427 315730014633 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730014634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730014635 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 315730014636 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 315730014637 active site 315730014638 HIGH motif; other site 315730014639 dimer interface [polypeptide binding]; other site 315730014640 KMSKS motif; other site 315730014641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730014642 RNA binding surface [nucleotide binding]; other site 315730014643 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 315730014644 FAD binding domain; Region: FAD_binding_4; pfam01565 315730014645 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315730014646 SET domain; Region: SET; pfam00856 315730014647 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 315730014648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730014649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014650 dimer interface [polypeptide binding]; other site 315730014651 putative CheW interface [polypeptide binding]; other site 315730014652 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 315730014653 putative phosphate binding site [ion binding]; other site 315730014654 camphor resistance protein CrcB; Provisional; Region: PRK14219 315730014655 camphor resistance protein CrcB; Provisional; Region: PRK14205 315730014656 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 315730014657 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 315730014658 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730014659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730014660 Coenzyme A binding pocket [chemical binding]; other site 315730014661 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 315730014662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 315730014663 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730014664 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315730014665 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 315730014666 AsnC family; Region: AsnC_trans_reg; pfam01037 315730014667 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315730014668 active site clefts [active] 315730014669 zinc binding site [ion binding]; other site 315730014670 dimer interface [polypeptide binding]; other site 315730014671 cyanate hydratase; Validated; Region: PRK02866 315730014672 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 315730014673 oligomer interface [polypeptide binding]; other site 315730014674 active site 315730014675 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730014676 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 315730014677 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 315730014678 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730014679 Walker A/P-loop; other site 315730014680 ATP binding site [chemical binding]; other site 315730014681 Q-loop/lid; other site 315730014682 ABC transporter signature motif; other site 315730014683 Walker B; other site 315730014684 D-loop; other site 315730014685 H-loop/switch region; other site 315730014686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730014687 ABC-ATPase subunit interface; other site 315730014688 dimer interface [polypeptide binding]; other site 315730014689 putative PBP binding regions; other site 315730014690 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730014691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730014692 ABC-ATPase subunit interface; other site 315730014693 dimer interface [polypeptide binding]; other site 315730014694 putative PBP binding regions; other site 315730014695 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 315730014696 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730014697 intersubunit interface [polypeptide binding]; other site 315730014698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014700 active site 315730014701 phosphorylation site [posttranslational modification] 315730014702 intermolecular recognition site; other site 315730014703 dimerization interface [polypeptide binding]; other site 315730014704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014705 DNA binding site [nucleotide binding] 315730014706 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 315730014707 SmpB-tmRNA interface; other site 315730014708 ribonuclease R; Region: RNase_R; TIGR02063 315730014709 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 315730014710 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730014711 RNB domain; Region: RNB; pfam00773 315730014712 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 315730014713 RNA binding site [nucleotide binding]; other site 315730014714 Esterase/lipase [General function prediction only]; Region: COG1647 315730014715 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 315730014716 holin-like protein; Validated; Region: PRK01658 315730014717 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730014718 active site 315730014719 enolase; Provisional; Region: eno; PRK00077 315730014720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 315730014721 dimer interface [polypeptide binding]; other site 315730014722 metal binding site [ion binding]; metal-binding site 315730014723 substrate binding pocket [chemical binding]; other site 315730014724 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 315730014725 phosphoglyceromutase; Provisional; Region: PRK05434 315730014726 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 315730014727 triosephosphate isomerase; Provisional; Region: PRK14565 315730014728 substrate binding site [chemical binding]; other site 315730014729 dimer interface [polypeptide binding]; other site 315730014730 catalytic triad [active] 315730014731 Phosphoglycerate kinase; Region: PGK; pfam00162 315730014732 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 315730014733 substrate binding site [chemical binding]; other site 315730014734 hinge regions; other site 315730014735 ADP binding site [chemical binding]; other site 315730014736 catalytic site [active] 315730014737 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 315730014738 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 315730014739 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 315730014740 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730014741 Predicted transcriptional regulator [Transcription]; Region: COG3388 315730014742 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730014743 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 315730014744 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 315730014745 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 315730014746 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 315730014747 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 315730014748 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730014749 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730014750 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 315730014751 stage V sporulation protein AD; Provisional; Region: PRK12404 315730014752 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 315730014753 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 315730014754 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730014755 Predicted membrane protein [Function unknown]; Region: COG2323 315730014756 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730014757 Clp protease; Region: CLP_protease; pfam00574 315730014758 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315730014759 oligomer interface [polypeptide binding]; other site 315730014760 active site residues [active] 315730014761 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315730014762 dimerization domain swap beta strand [polypeptide binding]; other site 315730014763 regulatory protein interface [polypeptide binding]; other site 315730014764 active site 315730014765 regulatory phosphorylation site [posttranslational modification]; other site 315730014766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 315730014767 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 315730014768 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 315730014769 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 315730014770 phosphate binding site [ion binding]; other site 315730014771 putative substrate binding pocket [chemical binding]; other site 315730014772 dimer interface [polypeptide binding]; other site 315730014773 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 315730014774 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730014775 putative active site [active] 315730014776 nucleotide binding site [chemical binding]; other site 315730014777 nudix motif; other site 315730014778 putative metal binding site [ion binding]; other site 315730014779 Domain of unknown function (DUF368); Region: DUF368; pfam04018 315730014780 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 315730014781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 315730014782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730014783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730014784 binding surface 315730014785 TPR motif; other site 315730014786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730014787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730014788 binding surface 315730014789 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730014790 TPR motif; other site 315730014791 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 315730014792 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 315730014793 trimer interface [polypeptide binding]; other site 315730014794 active site 315730014795 substrate binding site [chemical binding]; other site 315730014796 CoA binding site [chemical binding]; other site 315730014797 pyrophosphatase PpaX; Provisional; Region: PRK13288 315730014798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014799 active site 315730014800 motif I; other site 315730014801 motif II; other site 315730014802 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 315730014803 HPr kinase/phosphorylase; Provisional; Region: PRK05428 315730014804 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 315730014805 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 315730014806 Hpr binding site; other site 315730014807 active site 315730014808 homohexamer subunit interaction site [polypeptide binding]; other site 315730014809 Predicted membrane protein [Function unknown]; Region: COG1950 315730014810 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 315730014811 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 315730014812 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 315730014813 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 315730014814 excinuclease ABC subunit B; Provisional; Region: PRK05298 315730014815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730014816 ATP binding site [chemical binding]; other site 315730014817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014818 nucleotide binding region [chemical binding]; other site 315730014819 ATP-binding site [chemical binding]; other site 315730014820 Ultra-violet resistance protein B; Region: UvrB; pfam12344 315730014821 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 315730014822 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730014823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730014824 DNA binding residues [nucleotide binding] 315730014825 dimer interface [polypeptide binding]; other site 315730014826 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730014827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730014828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730014829 non-specific DNA binding site [nucleotide binding]; other site 315730014830 salt bridge; other site 315730014831 sequence-specific DNA binding site [nucleotide binding]; other site 315730014832 Predicted membrane protein [Function unknown]; Region: COG2855 315730014833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730014834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730014835 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 315730014836 putative dimerization interface [polypeptide binding]; other site 315730014837 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 315730014838 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730014839 DNA binding residues [nucleotide binding] 315730014840 putative dimer interface [polypeptide binding]; other site 315730014841 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 315730014842 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 315730014843 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730014844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730014845 ABC transporter; Region: ABC_tran_2; pfam12848 315730014846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730014847 hypothetical protein; Provisional; Region: PRK12855 315730014848 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730014849 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 315730014850 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 315730014851 Walker A/P-loop; other site 315730014852 ATP binding site [chemical binding]; other site 315730014853 Q-loop/lid; other site 315730014854 ABC transporter signature motif; other site 315730014855 Walker B; other site 315730014856 D-loop; other site 315730014857 H-loop/switch region; other site 315730014858 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730014859 protein binding site [polypeptide binding]; other site 315730014860 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315730014861 C-terminal peptidase (prc); Region: prc; TIGR00225 315730014862 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315730014863 protein binding site [polypeptide binding]; other site 315730014864 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315730014865 Catalytic dyad [active] 315730014866 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 315730014867 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 315730014868 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 315730014869 FtsX-like permease family; Region: FtsX; pfam02687 315730014870 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 315730014871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730014872 Walker A/P-loop; other site 315730014873 ATP binding site [chemical binding]; other site 315730014874 Q-loop/lid; other site 315730014875 ABC transporter signature motif; other site 315730014876 Walker B; other site 315730014877 D-loop; other site 315730014878 H-loop/switch region; other site 315730014879 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 315730014880 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 315730014881 peptide chain release factor 2; Provisional; Region: PRK06746 315730014882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 315730014883 RF-1 domain; Region: RF-1; pfam00472 315730014884 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 315730014885 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 315730014886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 315730014887 nucleotide binding region [chemical binding]; other site 315730014888 ATP-binding site [chemical binding]; other site 315730014889 SEC-C motif; Region: SEC-C; pfam02810 315730014890 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730014891 active site 315730014892 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 315730014893 30S subunit binding site; other site 315730014894 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 315730014895 DNA-binding site [nucleotide binding]; DNA binding site 315730014896 RNA-binding motif; other site 315730014897 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 315730014898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730014899 active site 315730014900 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 315730014901 DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers; Region: NR_DBD_like; cl02596 315730014902 zinc binding site [ion binding]; other site 315730014903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730014904 ATP binding site [chemical binding]; other site 315730014905 putative Mg++ binding site [ion binding]; other site 315730014906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014907 nucleotide binding region [chemical binding]; other site 315730014908 ATP-binding site [chemical binding]; other site 315730014909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730014910 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730014911 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315730014912 NlpC/P60 family; Region: NLPC_P60; pfam00877 315730014913 Predicted transcriptional regulators [Transcription]; Region: COG1733 315730014914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730014915 dimerization interface [polypeptide binding]; other site 315730014916 putative Zn2+ binding site [ion binding]; other site 315730014917 putative DNA binding site [nucleotide binding]; other site 315730014918 EDD domain protein, DegV family; Region: DegV; TIGR00762 315730014919 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 315730014920 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 315730014921 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 315730014922 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 315730014923 Transcriptional regulator [Transcription]; Region: LytR; COG1316 315730014924 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 315730014925 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 315730014926 active site 315730014927 homodimer interface [polypeptide binding]; other site 315730014928 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730014929 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315730014930 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730014931 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315730014932 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 315730014933 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 315730014934 Mg++ binding site [ion binding]; other site 315730014935 putative catalytic motif [active] 315730014936 substrate binding site [chemical binding]; other site 315730014937 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 315730014938 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730014939 NodB motif; other site 315730014940 active site 315730014941 catalytic site [active] 315730014942 Zn binding site [ion binding]; other site 315730014943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730014944 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730014945 Walker A motif; other site 315730014946 ATP binding site [chemical binding]; other site 315730014947 Walker B motif; other site 315730014948 arginine finger; other site 315730014949 Transcriptional antiterminator [Transcription]; Region: COG3933 315730014950 PRD domain; Region: PRD; pfam00874 315730014951 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 315730014952 active pocket/dimerization site; other site 315730014953 active site 315730014954 phosphorylation site [posttranslational modification] 315730014955 PRD domain; Region: PRD; pfam00874 315730014956 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 315730014957 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 315730014958 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 315730014959 Chromate transporter; Region: Chromate_transp; pfam02417 315730014960 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 315730014961 putative active site [active] 315730014962 YdjC motif; other site 315730014963 Mg binding site [ion binding]; other site 315730014964 putative homodimer interface [polypeptide binding]; other site 315730014965 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315730014966 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315730014967 NAD binding site [chemical binding]; other site 315730014968 sugar binding site [chemical binding]; other site 315730014969 divalent metal binding site [ion binding]; other site 315730014970 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730014971 dimer interface [polypeptide binding]; other site 315730014972 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730014973 active site 315730014974 methionine cluster; other site 315730014975 phosphorylation site [posttranslational modification] 315730014976 metal binding site [ion binding]; metal-binding site 315730014977 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730014978 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 315730014979 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730014980 active site 315730014981 P-loop; other site 315730014982 phosphorylation site [posttranslational modification] 315730014983 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730014984 methionine cluster; other site 315730014985 active site 315730014986 phosphorylation site [posttranslational modification] 315730014987 metal binding site [ion binding]; metal-binding site 315730014988 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730014989 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 315730014990 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730014991 active site 315730014992 P-loop; other site 315730014993 phosphorylation site [posttranslational modification] 315730014994 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 315730014995 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730014996 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315730014997 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 315730014998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730014999 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730015000 Predicted membrane protein [Function unknown]; Region: COG1511 315730015001 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730015002 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 315730015003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730015004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 315730015005 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 315730015006 putative dimerization interface [polypeptide binding]; other site 315730015007 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 315730015008 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 315730015009 arsenical pump membrane protein; Provisional; Region: PRK15445 315730015010 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 315730015011 transmembrane helices; other site 315730015012 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 315730015013 ThiC-associated domain; Region: ThiC-associated; pfam13667 315730015014 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 315730015015 L-lactate permease; Region: Lactate_perm; cl00701 315730015016 glycolate transporter; Provisional; Region: PRK09695 315730015017 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 315730015018 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315730015019 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730015020 Sulfatase; Region: Sulfatase; pfam00884 315730015021 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 315730015022 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730015023 homodimer interface [polypeptide binding]; other site 315730015024 substrate-cofactor binding pocket; other site 315730015025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730015026 catalytic residue [active] 315730015027 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015028 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015029 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015030 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015031 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015032 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 315730015033 NlpC/P60 family; Region: NLPC_P60; pfam00877 315730015034 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730015035 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730015036 Nucleoside recognition; Region: Gate; pfam07670 315730015037 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730015038 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730015039 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 315730015040 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 315730015041 DXD motif; other site 315730015042 BCCT family transporter; Region: BCCT; pfam02028 315730015043 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015044 Bacterial SH3 domain; Region: SH3_3; pfam08239 315730015045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 315730015046 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 315730015047 Predicted membrane protein [Function unknown]; Region: COG4640 315730015048 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 315730015049 Double zinc ribbon; Region: DZR; pfam12773 315730015050 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 315730015051 Double zinc ribbon; Region: DZR; pfam12773 315730015052 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 315730015053 SNF2 Helicase protein; Region: DUF3670; pfam12419 315730015054 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315730015055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730015056 ATP binding site [chemical binding]; other site 315730015057 putative Mg++ binding site [ion binding]; other site 315730015058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730015059 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 315730015060 nucleotide binding region [chemical binding]; other site 315730015061 ATP-binding site [chemical binding]; other site 315730015062 Predicted integral membrane protein [Function unknown]; Region: COG5652 315730015063 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 315730015064 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 315730015065 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 315730015066 ComK protein; Region: ComK; cl11560 315730015067 RNA polymerase factor sigma-70; Validated; Region: PRK06759 315730015068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730015069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730015070 DNA binding residues [nucleotide binding] 315730015071 Yip1 domain; Region: Yip1; cl17815 315730015072 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 315730015073 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730015074 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730015075 FtsX-like permease family; Region: FtsX; pfam02687 315730015076 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730015077 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 315730015078 Walker A/P-loop; other site 315730015079 ATP binding site [chemical binding]; other site 315730015080 Q-loop/lid; other site 315730015081 ABC transporter signature motif; other site 315730015082 Walker B; other site 315730015083 D-loop; other site 315730015084 H-loop/switch region; other site 315730015085 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 315730015086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 315730015087 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 315730015088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730015089 putative substrate translocation pore; other site 315730015090 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730015091 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 315730015092 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 315730015093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730015094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730015095 dimerization interface [polypeptide binding]; other site 315730015096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730015097 dimer interface [polypeptide binding]; other site 315730015098 phosphorylation site [posttranslational modification] 315730015099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730015100 ATP binding site [chemical binding]; other site 315730015101 Mg2+ binding site [ion binding]; other site 315730015102 G-X-G motif; other site 315730015103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730015104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015105 active site 315730015106 phosphorylation site [posttranslational modification] 315730015107 intermolecular recognition site; other site 315730015108 dimerization interface [polypeptide binding]; other site 315730015109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730015110 DNA binding site [nucleotide binding] 315730015111 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 315730015112 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315730015113 NAD binding site [chemical binding]; other site 315730015114 homodimer interface [polypeptide binding]; other site 315730015115 active site 315730015116 substrate binding site [chemical binding]; other site 315730015117 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 315730015118 catalytic triad [active] 315730015119 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 315730015120 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 315730015121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 315730015122 UDP-galactopyranose mutase; Region: GLF; pfam03275 315730015123 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315730015124 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 315730015125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730015126 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730015127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730015128 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 315730015129 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 315730015130 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 315730015131 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730015132 putative NAD(P) binding site [chemical binding]; other site 315730015133 active site 315730015134 putative substrate binding site [chemical binding]; other site 315730015135 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730015136 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 315730015137 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730015138 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 315730015139 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315730015140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730015141 putative ADP-binding pocket [chemical binding]; other site 315730015142 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730015143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730015144 NAD(P) binding site [chemical binding]; other site 315730015145 active site 315730015146 Bacterial sugar transferase; Region: Bac_transf; pfam02397 315730015147 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315730015148 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315730015149 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730015150 NAD(P) binding site [chemical binding]; other site 315730015151 homodimer interface [polypeptide binding]; other site 315730015152 substrate binding site [chemical binding]; other site 315730015153 active site 315730015154 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315730015155 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 315730015156 active site 315730015157 tetramer interface; other site 315730015158 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 315730015159 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730015160 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315730015161 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315730015162 Chain length determinant protein; Region: Wzz; cl15801 315730015163 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730015164 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 315730015165 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315730015166 rod shape-determining protein Mbl; Provisional; Region: PRK13928 315730015167 MreB and similar proteins; Region: MreB_like; cd10225 315730015168 nucleotide binding site [chemical binding]; other site 315730015169 Mg binding site [ion binding]; other site 315730015170 putative protofilament interaction site [polypeptide binding]; other site 315730015171 RodZ interaction site [polypeptide binding]; other site 315730015172 Stage III sporulation protein D; Region: SpoIIID; pfam12116 315730015173 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 315730015174 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730015175 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 315730015176 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315730015177 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730015178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730015179 Walker A/P-loop; other site 315730015180 ATP binding site [chemical binding]; other site 315730015181 Q-loop/lid; other site 315730015182 ABC transporter signature motif; other site 315730015183 Walker B; other site 315730015184 D-loop; other site 315730015185 H-loop/switch region; other site 315730015186 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730015187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730015188 Walker A/P-loop; other site 315730015189 ATP binding site [chemical binding]; other site 315730015190 Q-loop/lid; other site 315730015191 ABC transporter signature motif; other site 315730015192 Walker B; other site 315730015193 D-loop; other site 315730015194 H-loop/switch region; other site 315730015195 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 315730015196 LytTr DNA-binding domain; Region: LytTR; pfam04397 315730015197 Stage II sporulation protein; Region: SpoIID; pfam08486 315730015198 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 315730015199 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315730015200 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315730015201 hinge; other site 315730015202 active site 315730015203 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 315730015204 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 315730015205 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 315730015206 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 315730015207 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 315730015208 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 315730015209 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 315730015210 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 315730015211 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 315730015212 Domain of unknown function (DUF373); Region: DUF373; cl12079 315730015213 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 315730015214 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 315730015215 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 315730015216 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 315730015217 4Fe-4S binding domain; Region: Fer4; cl02805 315730015218 4Fe-4S binding domain; Region: Fer4; pfam00037 315730015219 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 315730015220 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 315730015221 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 315730015222 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 315730015223 NADH dehydrogenase subunit C; Validated; Region: PRK07735 315730015224 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 315730015225 NADH dehydrogenase subunit B; Validated; Region: PRK06411 315730015226 NADH dehydrogenase subunit A; Validated; Region: PRK07756 315730015227 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 315730015228 PAS domain S-box; Region: sensory_box; TIGR00229 315730015229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730015230 putative active site [active] 315730015231 heme pocket [chemical binding]; other site 315730015232 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730015233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730015234 metal binding site [ion binding]; metal-binding site 315730015235 active site 315730015236 I-site; other site 315730015237 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730015238 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730015239 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730015240 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 315730015241 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 315730015242 gamma subunit interface [polypeptide binding]; other site 315730015243 epsilon subunit interface [polypeptide binding]; other site 315730015244 LBP interface [polypeptide binding]; other site 315730015245 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 315730015246 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 315730015247 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 315730015248 alpha subunit interaction interface [polypeptide binding]; other site 315730015249 Walker A motif; other site 315730015250 ATP binding site [chemical binding]; other site 315730015251 Walker B motif; other site 315730015252 inhibitor binding site; inhibition site 315730015253 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315730015254 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 315730015255 core domain interface [polypeptide binding]; other site 315730015256 delta subunit interface [polypeptide binding]; other site 315730015257 epsilon subunit interface [polypeptide binding]; other site 315730015258 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 315730015259 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 315730015260 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 315730015261 beta subunit interaction interface [polypeptide binding]; other site 315730015262 Walker A motif; other site 315730015263 ATP binding site [chemical binding]; other site 315730015264 Walker B motif; other site 315730015265 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315730015266 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 315730015267 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 315730015268 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 315730015269 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 315730015270 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 315730015271 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 315730015272 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 315730015273 ATP synthase I chain; Region: ATP_synt_I; pfam03899 315730015274 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 315730015275 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 315730015276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730015277 active site 315730015278 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 315730015279 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 315730015280 dimer interface [polypeptide binding]; other site 315730015281 active site 315730015282 glycine-pyridoxal phosphate binding site [chemical binding]; other site 315730015283 folate binding site [chemical binding]; other site 315730015284 hypothetical protein; Provisional; Region: PRK13690 315730015285 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 315730015286 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 315730015287 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730015288 active site 315730015289 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315730015290 HPr interaction site; other site 315730015291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315730015292 active site 315730015293 phosphorylation site [posttranslational modification] 315730015294 Predicted membrane protein [Function unknown]; Region: COG2259 315730015295 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 315730015296 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 315730015297 Domain of unknown function DUF; Region: DUF204; pfam02659 315730015298 Domain of unknown function DUF; Region: DUF204; pfam02659 315730015299 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 315730015300 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 315730015301 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 315730015302 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 315730015303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730015304 S-adenosylmethionine binding site [chemical binding]; other site 315730015305 peptide chain release factor 1; Validated; Region: prfA; PRK00591 315730015306 This domain is found in peptide chain release factors; Region: PCRF; smart00937 315730015307 RF-1 domain; Region: RF-1; pfam00472 315730015308 thymidine kinase; Provisional; Region: PRK04296 315730015309 LabA_like proteins; Region: LabA_like/DUF88; cl10034 315730015310 putative metal binding site [ion binding]; other site 315730015311 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 315730015312 transcription termination factor Rho; Provisional; Region: rho; PRK09376 315730015313 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 315730015314 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 315730015315 RNA binding site [nucleotide binding]; other site 315730015316 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 315730015317 multimer interface [polypeptide binding]; other site 315730015318 Walker A motif; other site 315730015319 ATP binding site [chemical binding]; other site 315730015320 Walker B motif; other site 315730015321 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315730015322 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 315730015323 putative active site [active] 315730015324 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315730015325 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315730015326 hinge; other site 315730015327 active site 315730015328 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 315730015329 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315730015330 intersubunit interface [polypeptide binding]; other site 315730015331 active site 315730015332 zinc binding site [ion binding]; other site 315730015333 Na+ binding site [ion binding]; other site 315730015334 Response regulator receiver domain; Region: Response_reg; pfam00072 315730015335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015336 active site 315730015337 phosphorylation site [posttranslational modification] 315730015338 intermolecular recognition site; other site 315730015339 dimerization interface [polypeptide binding]; other site 315730015340 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 315730015341 CTP synthetase; Validated; Region: pyrG; PRK05380 315730015342 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 315730015343 Catalytic site [active] 315730015344 active site 315730015345 UTP binding site [chemical binding]; other site 315730015346 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 315730015347 active site 315730015348 putative oxyanion hole; other site 315730015349 catalytic triad [active] 315730015350 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 315730015351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730015352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730015353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730015354 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730015355 FAD binding site [chemical binding]; other site 315730015356 homotetramer interface [polypeptide binding]; other site 315730015357 substrate binding pocket [chemical binding]; other site 315730015358 catalytic base [active] 315730015359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730015360 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730015361 FAD binding site [chemical binding]; other site 315730015362 homotetramer interface [polypeptide binding]; other site 315730015363 substrate binding pocket [chemical binding]; other site 315730015364 catalytic base [active] 315730015365 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 315730015366 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 315730015367 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730015368 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 315730015369 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730015370 dimer interface [polypeptide binding]; other site 315730015371 active site 315730015372 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 315730015373 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315730015374 4Fe-4S binding domain; Region: Fer4; cl02805 315730015375 Cysteine-rich domain; Region: CCG; pfam02754 315730015376 Cysteine-rich domain; Region: CCG; pfam02754 315730015377 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730015378 PLD-like domain; Region: PLDc_2; pfam13091 315730015379 putative active site [active] 315730015380 catalytic site [active] 315730015381 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730015382 PLD-like domain; Region: PLDc_2; pfam13091 315730015383 putative active site [active] 315730015384 catalytic site [active] 315730015385 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 315730015386 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 315730015387 PAS domain S-box; Region: sensory_box; TIGR00229 315730015388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730015389 putative active site [active] 315730015390 heme pocket [chemical binding]; other site 315730015391 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730015392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730015393 metal binding site [ion binding]; metal-binding site 315730015394 active site 315730015395 I-site; other site 315730015396 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730015397 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 315730015398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730015399 non-specific DNA binding site [nucleotide binding]; other site 315730015400 salt bridge; other site 315730015401 sequence-specific DNA binding site [nucleotide binding]; other site 315730015402 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730015403 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730015404 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730015405 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730015406 active site 315730015407 Zn binding site [ion binding]; other site 315730015408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730015409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015410 active site 315730015411 phosphorylation site [posttranslational modification] 315730015412 intermolecular recognition site; other site 315730015413 dimerization interface [polypeptide binding]; other site 315730015414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730015415 DNA binding residues [nucleotide binding] 315730015416 dimerization interface [polypeptide binding]; other site 315730015417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730015418 VIT family; Region: VIT1; pfam01988 315730015419 Histidine kinase; Region: HisKA_3; pfam07730 315730015420 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 315730015421 ATP binding site [chemical binding]; other site 315730015422 Mg2+ binding site [ion binding]; other site 315730015423 G-X-G motif; other site 315730015424 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 315730015425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730015426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 315730015427 Walker A/P-loop; other site 315730015428 ATP binding site [chemical binding]; other site 315730015429 Q-loop/lid; other site 315730015430 ABC transporter signature motif; other site 315730015431 Walker B; other site 315730015432 D-loop; other site 315730015433 H-loop/switch region; other site 315730015434 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730015435 active site 315730015436 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730015437 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 315730015438 PA/protease or protease-like domain interface [polypeptide binding]; other site 315730015439 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 315730015440 Peptidase family M28; Region: Peptidase_M28; pfam04389 315730015441 metal binding site [ion binding]; metal-binding site 315730015442 Collagen binding domain; Region: Collagen_bind; pfam05737 315730015443 Cna protein B-type domain; Region: Cna_B; pfam05738 315730015444 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015445 domain interaction interfaces [polypeptide binding]; other site 315730015446 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015447 domain interaction interfaces [polypeptide binding]; other site 315730015448 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015449 domain interaction interfaces [polypeptide binding]; other site 315730015450 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015451 domain interaction interfaces [polypeptide binding]; other site 315730015452 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015453 domain interaction interfaces [polypeptide binding]; other site 315730015454 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015455 domain interaction interfaces [polypeptide binding]; other site 315730015456 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015457 domain interaction interfaces [polypeptide binding]; other site 315730015458 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015459 domain interaction interfaces [polypeptide binding]; other site 315730015460 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015461 domain interaction interfaces [polypeptide binding]; other site 315730015462 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015463 domain interaction interfaces [polypeptide binding]; other site 315730015464 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015465 domain interaction interfaces [polypeptide binding]; other site 315730015466 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015467 domain interaction interfaces [polypeptide binding]; other site 315730015468 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015469 domain interaction interfaces [polypeptide binding]; other site 315730015470 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015471 domain interaction interfaces [polypeptide binding]; other site 315730015472 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015473 domain interaction interfaces [polypeptide binding]; other site 315730015474 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015475 domain interaction interfaces [polypeptide binding]; other site 315730015476 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015477 domain interaction interfaces [polypeptide binding]; other site 315730015478 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015479 domain interaction interfaces [polypeptide binding]; other site 315730015480 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015481 domain interaction interfaces [polypeptide binding]; other site 315730015482 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 315730015483 domain interaction interfaces [polypeptide binding]; other site 315730015484 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 315730015485 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 315730015486 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 315730015487 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315730015488 active site 315730015489 HIGH motif; other site 315730015490 KMSK motif region; other site 315730015491 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315730015492 tRNA binding surface [nucleotide binding]; other site 315730015493 anticodon binding site; other site 315730015494 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 315730015495 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 315730015496 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315730015497 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 315730015498 agmatinase; Region: agmatinase; TIGR01230 315730015499 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 315730015500 putative active site [active] 315730015501 Mn binding site [ion binding]; other site 315730015502 spermidine synthase; Provisional; Region: PRK00811 315730015503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730015504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730015505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730015506 putative substrate translocation pore; other site 315730015507 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730015508 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 315730015509 DNA binding residues [nucleotide binding] 315730015510 putative dimer interface [polypeptide binding]; other site 315730015511 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730015512 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315730015513 active site 315730015514 catalytic site [active] 315730015515 metal binding site [ion binding]; metal-binding site 315730015516 dimer interface [polypeptide binding]; other site 315730015517 Transglycosylase; Region: Transgly; pfam00912 315730015518 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730015519 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 315730015520 YwhD family; Region: YwhD; pfam08741 315730015521 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 315730015522 Peptidase family M50; Region: Peptidase_M50; pfam02163 315730015523 active site 315730015524 putative substrate binding region [chemical binding]; other site 315730015525 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 315730015526 active site 1 [active] 315730015527 dimer interface [polypeptide binding]; other site 315730015528 hexamer interface [polypeptide binding]; other site 315730015529 active site 2 [active] 315730015530 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 315730015531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730015532 Zn2+ binding site [ion binding]; other site 315730015533 Mg2+ binding site [ion binding]; other site 315730015534 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730015535 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730015536 intersubunit interface [polypeptide binding]; other site 315730015537 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730015538 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730015539 Walker A/P-loop; other site 315730015540 ATP binding site [chemical binding]; other site 315730015541 Q-loop/lid; other site 315730015542 ABC transporter signature motif; other site 315730015543 Walker B; other site 315730015544 D-loop; other site 315730015545 H-loop/switch region; other site 315730015546 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 315730015547 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730015548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730015549 ABC-ATPase subunit interface; other site 315730015550 dimer interface [polypeptide binding]; other site 315730015551 putative PBP binding regions; other site 315730015552 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730015553 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730015554 ABC-ATPase subunit interface; other site 315730015555 dimer interface [polypeptide binding]; other site 315730015556 putative PBP binding regions; other site 315730015557 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315730015558 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730015559 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730015560 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315730015561 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 315730015562 putative heme peroxidase; Provisional; Region: PRK12276 315730015563 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730015564 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 315730015565 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 315730015566 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 315730015567 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730015568 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 315730015569 Protein of unknown function (DUF423); Region: DUF423; pfam04241 315730015570 Ion channel; Region: Ion_trans_2; pfam07885 315730015571 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730015572 TrkA-N domain; Region: TrkA_N; pfam02254 315730015573 TrkA-C domain; Region: TrkA_C; pfam02080 315730015574 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730015575 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730015576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730015577 motif II; other site 315730015578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730015579 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 315730015580 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 315730015581 ligand binding site [chemical binding]; other site 315730015582 active site 315730015583 UGI interface [polypeptide binding]; other site 315730015584 catalytic site [active] 315730015585 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 315730015586 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315730015587 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730015588 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 315730015589 Walker A/P-loop; other site 315730015590 ATP binding site [chemical binding]; other site 315730015591 Q-loop/lid; other site 315730015592 ABC transporter signature motif; other site 315730015593 Walker B; other site 315730015594 D-loop; other site 315730015595 H-loop/switch region; other site 315730015596 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 315730015597 active site 315730015598 catalytic triad [active] 315730015599 oxyanion hole [active] 315730015600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730015601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730015602 DNA binding site [nucleotide binding] 315730015603 domain linker motif; other site 315730015604 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730015605 putative dimerization interface [polypeptide binding]; other site 315730015606 putative ligand binding site [chemical binding]; other site 315730015607 Predicted membrane protein [Function unknown]; Region: COG2364 315730015608 homoserine dehydrogenase; Provisional; Region: PRK06349 315730015609 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 315730015610 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730015611 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315730015612 Homoserine O-succinyltransferase; Region: HTS; pfam04204 315730015613 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 315730015614 proposed active site lysine [active] 315730015615 conserved cys residue [active] 315730015616 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 315730015617 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730015618 homodimer interface [polypeptide binding]; other site 315730015619 substrate-cofactor binding pocket; other site 315730015620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730015621 catalytic residue [active] 315730015622 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 315730015623 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 315730015624 Cl- selectivity filter; other site 315730015625 Cl- binding residues [ion binding]; other site 315730015626 pore gating glutamate residue; other site 315730015627 dimer interface [polypeptide binding]; other site 315730015628 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 315730015629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730015630 active site 315730015631 motif I; other site 315730015632 motif II; other site 315730015633 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730015634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730015635 ligand binding site [chemical binding]; other site 315730015636 flexible hinge region; other site 315730015637 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 315730015638 azoreductase; Provisional; Region: PRK13556 315730015639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730015640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015641 active site 315730015642 phosphorylation site [posttranslational modification] 315730015643 intermolecular recognition site; other site 315730015644 dimerization interface [polypeptide binding]; other site 315730015645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730015646 DNA binding residues [nucleotide binding] 315730015647 dimerization interface [polypeptide binding]; other site 315730015648 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 315730015649 GAF domain; Region: GAF; pfam01590 315730015650 GAF domain; Region: GAF_3; pfam13492 315730015651 GAF domain; Region: GAF_2; pfam13185 315730015652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730015653 Histidine kinase; Region: HisKA_3; pfam07730 315730015654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730015655 ATP binding site [chemical binding]; other site 315730015656 Mg2+ binding site [ion binding]; other site 315730015657 G-X-G motif; other site 315730015658 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315730015659 dimer interface [polypeptide binding]; other site 315730015660 substrate binding site [chemical binding]; other site 315730015661 ATP binding site [chemical binding]; other site 315730015662 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315730015663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 315730015664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730015665 metal binding site [ion binding]; metal-binding site 315730015666 active site 315730015667 I-site; other site 315730015668 Protein of unknown function (DUF466); Region: DUF466; pfam04328 315730015669 carbon starvation protein A; Provisional; Region: PRK15015 315730015670 Carbon starvation protein CstA; Region: CstA; pfam02554 315730015671 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 315730015672 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 315730015673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015674 active site 315730015675 phosphorylation site [posttranslational modification] 315730015676 intermolecular recognition site; other site 315730015677 dimerization interface [polypeptide binding]; other site 315730015678 LytTr DNA-binding domain; Region: LytTR; pfam04397 315730015679 benzoate transport; Region: 2A0115; TIGR00895 315730015680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730015681 putative substrate translocation pore; other site 315730015682 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 315730015683 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 315730015684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730015685 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730015686 Predicted membrane protein [Function unknown]; Region: COG2860 315730015687 UPF0126 domain; Region: UPF0126; pfam03458 315730015688 UPF0126 domain; Region: UPF0126; pfam03458 315730015689 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 315730015690 heme-binding site [chemical binding]; other site 315730015691 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730015692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730015693 dimer interface [polypeptide binding]; other site 315730015694 putative CheW interface [polypeptide binding]; other site 315730015695 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 315730015696 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315730015697 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730015698 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 315730015699 Ligand binding site; other site 315730015700 Putative Catalytic site; other site 315730015701 DXD motif; other site 315730015702 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315730015703 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 315730015704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730015705 active site 315730015706 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730015707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 315730015708 Walker A/P-loop; other site 315730015709 ATP binding site [chemical binding]; other site 315730015710 Q-loop/lid; other site 315730015711 ABC transporter signature motif; other site 315730015712 Walker B; other site 315730015713 D-loop; other site 315730015714 H-loop/switch region; other site 315730015715 ABC transporter; Region: ABC_tran_2; pfam12848 315730015716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 315730015717 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 315730015718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730015719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 315730015720 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315730015721 Protein export membrane protein; Region: SecD_SecF; cl14618 315730015722 methionine sulfoxide reductase A; Provisional; Region: PRK14054 315730015723 methionine sulfoxide reductase B; Provisional; Region: PRK00222 315730015724 SelR domain; Region: SelR; pfam01641 315730015725 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730015726 antiholin-like protein LrgB; Provisional; Region: PRK04288 315730015727 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 315730015728 two-component response regulator; Provisional; Region: PRK14084 315730015729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015730 active site 315730015731 phosphorylation site [posttranslational modification] 315730015732 intermolecular recognition site; other site 315730015733 dimerization interface [polypeptide binding]; other site 315730015734 LytTr DNA-binding domain; Region: LytTR; pfam04397 315730015735 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 315730015736 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 315730015737 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 315730015738 Histidine kinase; Region: His_kinase; pfam06580 315730015739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730015740 ATP binding site [chemical binding]; other site 315730015741 Mg2+ binding site [ion binding]; other site 315730015742 G-X-G motif; other site 315730015743 benzoate transport; Region: 2A0115; TIGR00895 315730015744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730015745 putative substrate translocation pore; other site 315730015746 BCCT family transporter; Region: BCCT; pfam02028 315730015747 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 315730015748 active site 315730015749 dimer interface [polypeptide binding]; other site 315730015750 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730015751 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730015752 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730015753 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730015754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730015755 NAD(P) binding site [chemical binding]; other site 315730015756 active site 315730015757 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 315730015758 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315730015759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730015760 Predicted membrane protein [Function unknown]; Region: COG4267 315730015761 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315730015762 UDP-glucose 4-epimerase; Region: PLN02240 315730015763 NAD binding site [chemical binding]; other site 315730015764 homodimer interface [polypeptide binding]; other site 315730015765 active site 315730015766 substrate binding site [chemical binding]; other site 315730015767 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 315730015768 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 315730015769 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315730015770 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 315730015771 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730015772 ATP binding site [chemical binding]; other site 315730015773 Mg++ binding site [ion binding]; other site 315730015774 motif III; other site 315730015775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730015776 nucleotide binding region [chemical binding]; other site 315730015777 ATP-binding site [chemical binding]; other site 315730015778 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 315730015779 RNA binding site [nucleotide binding]; other site 315730015780 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 315730015781 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 315730015782 active site 315730015783 oligoendopeptidase F; Region: pepF; TIGR00181 315730015784 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 315730015785 active site 315730015786 Zn binding site [ion binding]; other site 315730015787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730015788 FeS/SAM binding site; other site 315730015789 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 315730015790 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 315730015791 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 315730015792 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315730015793 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 315730015794 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730015795 protein binding site [polypeptide binding]; other site 315730015796 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 315730015797 YycH protein; Region: YycI; pfam09648 315730015798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 315730015799 YycH protein; Region: YycH; pfam07435 315730015800 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 315730015801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730015802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730015803 dimerization interface [polypeptide binding]; other site 315730015804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730015805 putative active site [active] 315730015806 heme pocket [chemical binding]; other site 315730015807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730015808 dimer interface [polypeptide binding]; other site 315730015809 phosphorylation site [posttranslational modification] 315730015810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730015811 ATP binding site [chemical binding]; other site 315730015812 Mg2+ binding site [ion binding]; other site 315730015813 G-X-G motif; other site 315730015814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730015815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730015816 active site 315730015817 phosphorylation site [posttranslational modification] 315730015818 intermolecular recognition site; other site 315730015819 dimerization interface [polypeptide binding]; other site 315730015820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730015821 DNA binding site [nucleotide binding] 315730015822 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 315730015823 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 315730015824 GDP-binding site [chemical binding]; other site 315730015825 ACT binding site; other site 315730015826 IMP binding site; other site 315730015827 replicative DNA helicase; Provisional; Region: PRK05748 315730015828 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730015829 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730015830 Walker A motif; other site 315730015831 ATP binding site [chemical binding]; other site 315730015832 Walker B motif; other site 315730015833 DNA binding loops [nucleotide binding] 315730015834 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 315730015835 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 315730015836 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 315730015837 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 315730015838 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730015839 DHH family; Region: DHH; pfam01368 315730015840 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 315730015841 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 315730015842 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315730015843 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730015844 dimer interface [polypeptide binding]; other site 315730015845 ssDNA binding site [nucleotide binding]; other site 315730015846 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730015847 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 315730015848 GTP-binding protein YchF; Reviewed; Region: PRK09601 315730015849 YchF GTPase; Region: YchF; cd01900 315730015850 G1 box; other site 315730015851 GTP/Mg2+ binding site [chemical binding]; other site 315730015852 Switch I region; other site 315730015853 G2 box; other site 315730015854 Switch II region; other site 315730015855 G3 box; other site 315730015856 G4 box; other site 315730015857 G5 box; other site 315730015858 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 315730015859 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 315730015860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 315730015861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315730015862 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 315730015863 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 315730015864 ParB-like nuclease domain; Region: ParB; smart00470 315730015865 KorB domain; Region: KorB; pfam08535 315730015866 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315730015867 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730015868 P-loop; other site 315730015869 Magnesium ion binding site [ion binding]; other site 315730015870 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730015871 Magnesium ion binding site [ion binding]; other site 315730015872 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 315730015873 ParB-like nuclease domain; Region: ParBc; pfam02195 315730015874 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 315730015875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730015876 S-adenosylmethionine binding site [chemical binding]; other site 315730015877 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 315730015878 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 315730015879 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 315730015880 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 315730015881 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 315730015882 trmE is a tRNA modification GTPase; Region: trmE; cd04164 315730015883 G1 box; other site 315730015884 GTP/Mg2+ binding site [chemical binding]; other site 315730015885 Switch I region; other site 315730015886 G2 box; other site 315730015887 Switch II region; other site 315730015888 G3 box; other site 315730015889 G4 box; other site 315730015890 G5 box; other site 315730015891 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 315730015892 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 315730015893 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 315730015894 G-X-X-G motif; other site 315730015895 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 315730015896 RxxxH motif; other site 315730015897 OxaA-like protein precursor; Validated; Region: PRK02944 315730015898 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 315730015899 ribonuclease P; Reviewed; Region: rnpA; PRK00499 315730015900 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399