-- dump date 20140619_000121 -- class Genbank::misc_feature -- table misc_feature_note -- id note 862908000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 862908000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000003 Walker A motif; other site 862908000004 ATP binding site [chemical binding]; other site 862908000005 Walker B motif; other site 862908000006 arginine finger; other site 862908000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 862908000008 DnaA box-binding interface [nucleotide binding]; other site 862908000009 HMMPfam hit to PF00308, Bacterial chromosomal replication initiator protein, DnaA, score 1.7e-121 862908000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 862908000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 862908000012 putative DNA binding surface [nucleotide binding]; other site 862908000013 dimer interface [polypeptide binding]; other site 862908000014 beta-clamp/clamp loader binding surface; other site 862908000015 beta-clamp/translesion DNA polymerase binding surface; other site 862908000016 HMMPfam hit to PF00712, DNA polymerase III, beta chain, score 6.7e-27 862908000017 HMMPfam hit to PF02767, DNA polymerase III, beta chain, score 1.2e-27 862908000018 HMMPfam hit to PF02768, DNA polymerase III, beta chain, score 2e-31 862908000019 recombination protein F; Reviewed; Region: recF; PRK00064 862908000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000021 Walker A/P-loop; other site 862908000022 ATP binding site [chemical binding]; other site 862908000023 Q-loop/lid; other site 862908000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000025 ABC transporter signature motif; other site 862908000026 Walker B; other site 862908000027 D-loop; other site 862908000028 H-loop/switch region; other site 862908000029 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000030 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 862908000031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908000032 ATP binding site [chemical binding]; other site 862908000033 Mg2+ binding site [ion binding]; other site 862908000034 G-X-G motif; other site 862908000035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862908000036 anchoring element; other site 862908000037 dimer interface [polypeptide binding]; other site 862908000038 ATP binding site [chemical binding]; other site 862908000039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862908000040 active site 862908000041 putative metal-binding site [ion binding]; other site 862908000042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862908000043 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6e-26 862908000044 HMMPfam hit to PF00204, DNA topoisomerase II, score 9.2e-87 862908000045 HMMPfam hit to PF01751, TOPRIM, score 1.6e-11 862908000046 PS00177 DNA topoisomerase II signature. 862908000047 HMMPfam hit to PF00986, DNA gyrase, subunit B, C-terminal, score 9.7e-44 862908000048 DNA gyrase subunit A; Validated; Region: PRK05560 862908000049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 862908000050 CAP-like domain; other site 862908000051 active site 862908000052 primary dimer interface [polypeptide binding]; other site 862908000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862908000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862908000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862908000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862908000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862908000058 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 2.6e-296 862908000059 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 4.9e-13 862908000060 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 2.6e-07 862908000061 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 2.2e-10 862908000062 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 2.6e-14 862908000063 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 3.9e-13 862908000064 HMMPfam hit to PF03989, DNA gyrase C-terminal repeat, beta-propeller, score 1.6e-16 862908000065 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 862908000066 Signal peptide predicted for BMS0006 by SignalP 2.0 HMM (Signal peptide probability 0.784) with cleavage site probability 0.483 between residues 30 and 31 862908000067 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000068 HMMPfam hit to PF00515, TPR repeat, score 1.2 862908000069 HMMPfam hit to PF00515, TPR repeat, score 0.14; HMMPfam hit to PF07719, , score 0.52; PF07719, Tetratricopeptide repeat 862908000070 HMMPfam hit to PF00515, TPR repeat, score 0.39 862908000071 Signal peptide predicted for BMS0007 by SignalP 2.0 HMM (Signal peptide probability 0.743) with cleavage site probability 0.398 between residues 23 and 24 862908000072 2 probable transmembrane helices predicted for BMS0007 by TMHMM2.0 at aa 7-29 and 39-61 862908000073 Signal peptide predicted for BMS0008 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.892 between residues 27 and 28 862908000074 4 probable transmembrane helices predicted for BMS0008 by TMHMM2.0 at aa 12-29, 33-55, 74-96 and 100-118 862908000075 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 862908000076 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 862908000077 Signal peptide predicted for BMS0009 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 18 and 19 862908000078 5 probable transmembrane helices predicted for BMS0009 by TMHMM2.0 at aa 5-27, 37-56, 106-128, 168-190 and 220-242 862908000079 HMMPfam hit to PF00119, H+-transporting two-sector ATPase, A subunit, score 6.5e-23 862908000080 PS00449 ATP synthase a subunit signature. 862908000081 ATP synthase subunit C; Region: ATP-synt_C; cl00466 862908000082 Signal peptide predicted for BMS0010 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.784 between residues 22 and 23 862908000083 3 probable transmembrane helices predicted for BMS0010 by TMHMM2.0 at aa 4-21, 34-56 and 76-98 862908000084 HMMPfam hit to PF00137, H+-transporting two-sector ATPase, C subunit, score 2.4e-05 862908000085 PS00605 ATP synthase c subunit signature. 862908000086 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908000087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908000088 FeS/SAM binding site; other site 862908000089 HMMPfam hit to PF04055, Radical SAM, score 1e-08 862908000090 Signal peptide predicted for BMS0012 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.777 between residues 21 and 22 862908000091 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 862908000092 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 862908000093 catalytic motif [active] 862908000094 Zn binding site [ion binding]; other site 862908000095 RibD C-terminal domain; Region: RibD_C; cl17279 862908000096 HMMPfam hit to PF00383, Cytidine/deoxycytidylate deaminase, zinc-binding region, score 1.6e-29 862908000097 HMMPfam hit to PF01872, Bacterial bifunctional deaminase-reductase, C-terminal, score 6.4e-47 862908000098 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 862908000099 Lumazine binding domain; Region: Lum_binding; pfam00677 862908000100 Lumazine binding domain; Region: Lum_binding; pfam00677 862908000101 HMMPfam hit to PF00677, Lumazine-binding protein, score 6.9e-11 862908000102 HMMPfam hit to PF00677, Lumazine-binding protein, score 2.9e-24 862908000103 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 862908000104 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 862908000105 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 862908000106 dimerization interface [polypeptide binding]; other site 862908000107 active site 862908000108 HMMPfam hit to PF00926, 3,4-Dihydroxy-2-butanone 4-phosphate synthase, score 5.1e-114 862908000109 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 3e-85 862908000110 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 862908000111 homopentamer interface [polypeptide binding]; other site 862908000112 active site 862908000113 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 1.6e-80 862908000114 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 862908000115 active site 862908000116 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 862908000117 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862908000118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862908000119 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase (SpoU), score 3.2e-21 862908000120 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 862908000121 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 862908000122 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 862908000123 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 862908000124 HMMPfam hit to PF00005, ABC transporter, score 2.6e-22 862908000125 PS00211 ABC transporters family signature. 862908000126 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000127 HMMPfam hit to PF00005, ABC transporter, score 4.9e-09 862908000128 PS00211 ABC transporters family signature. 862908000129 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000130 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 862908000131 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 862908000132 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein PdxA, score 6.7e-18 862908000133 SurA N-terminal domain; Region: SurA_N; pfam09312 862908000134 Signal peptide predicted for BMS0021 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.985 between residues 18 and 19 862908000135 SurA N-terminal domain; Region: SurA_N_3; cl07813 862908000136 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 862908000137 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 862908000138 HMMPfam hit to PF00639, PpiC-type peptidyl-prolyl cis-trans isomerase, score 8.8e-18 862908000139 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 862908000140 Signal peptide predicted for BMS0022 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 20 and 21 862908000141 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 862908000142 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 862908000143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908000144 ATP binding site [chemical binding]; other site 862908000145 putative Mg++ binding site [ion binding]; other site 862908000146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908000147 nucleotide binding region [chemical binding]; other site 862908000148 ATP-binding site [chemical binding]; other site 862908000149 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 862908000150 HMMPfam hit to PF03461, TRCF, score 3.4e-14 862908000151 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.3e-19 862908000152 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 1.6e-33 862908000153 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3e-07 862908000154 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000155 HMMPfam hit to PF02559, Transcription factor CarD, score 8.6e-24 862908000156 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 862908000157 3 probable transmembrane helices predicted for BMS0024 by TMHMM2.0 at aa 10-32, 65-87 and 97-119 862908000158 PS00445 FGGY family of carbohydrate kinases signature 2. 862908000159 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3, score 3.7e-27 862908000160 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 862908000161 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 862908000162 8 probable transmembrane helices predicted for BMS0025 by TMHMM2.0 at aa 20-42, 94-116, 126-148, 165-187, 202-221, 252-274, 307-329 and 342-364 862908000163 HMMPfam hit to PF00146, Respiratory-chain NADH dehydrogenase, subunit 1, score 7.1e-106 862908000164 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 862908000165 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 862908000166 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 862908000167 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 862908000168 Signal peptide predicted for BMS0026 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.506 between residues 20 and 21 862908000169 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreductase, chain 6, score 1.1e-06 862908000170 5 probable transmembrane helices predicted for BMS0026 by TMHMM2.0 at aa 5-24, 31-53, 57-79, 100-122 and 147-169 862908000171 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 862908000172 3 probable transmembrane helices predicted for BMS0027 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 862908000173 HMMPfam hit to PF00420, NADH-ubiquinone oxidoreductase, chain 4L, score 3.7e-24 862908000174 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 862908000175 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862908000176 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862908000177 Signal peptide predicted for BMS0028 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.751 between residues 20 and 21 862908000178 15 probable transmembrane helices predicted for BMS0028 by TMHMM2.0 at aa 4-26, 33-52, 93-115, 127-144, 148-170, 191-213, 223-245, 266-288, 293-315, 322-344, 396-418, 439-461, 481-503, 578-600 and 708-725 862908000179 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal, score 6.3e-14 862908000180 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 2e-85 862908000181 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 862908000182 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862908000183 14 probable transmembrane helices predicted for BMS0029 by TMHMM2.0 at aa 10-27, 34-56, 88-110, 117-134, 138-160, 172-194, 229-251, 260-282, 292-314, 321-343, 348-370, 394-416, 431-453 and 474-496 862908000184 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 2.4e-78 862908000185 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 862908000186 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862908000187 13 probable transmembrane helices predicted for BMS0030 by TMHMM2.0 at aa 10-29, 42-64, 79-98, 111-128, 133-150, 170-192, 207-229, 242-264, 279-301, 332-354, 380-402, 415-434 and 460-482 862908000188 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1.5e-67 862908000189 3 probable transmembrane helices predicted for BMS0031 by TMHMM2.0 at aa 5-27, 47-69 and 79-98 862908000190 8 probable transmembrane helices predicted for BMS0032 by TMHMM2.0 at aa 4-26, 55-77, 92-113, 126-148, 163-185, 206-226, 241-263 and 276-294 862908000191 5 probable transmembrane helices predicted for BMS0033 by TMHMM2.0 at aa 4-20, 27-44, 48-67, 86-108 and 128-150 862908000192 Signal peptide predicted for BMS0034 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.834 between residues 26 and 27 862908000193 3 probable transmembrane helices predicted for BMS0034 by TMHMM2.0 at aa 4-23, 30-48 and 58-80 862908000194 13 probable transmembrane helices predicted for BMS0035 by TMHMM2.0 at aa 21-41, 51-73, 85-107, 120-142, 163-182, 202-224, 237-256, 261-279, 292-314, 324-343, 364-386, 406-428 and 484-503 862908000195 6 probable transmembrane helices predicted for BMS0036 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 131-153, 173-195 and 215-237 862908000196 10 probable transmembrane helices predicted for BMS0037 by TMHMM2.0 at aa 7-29, 49-71, 91-113, 123-145, 152-174, 189-208, 213-235, 245-264, 271-293 and 303-325 862908000197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000198 binding surface 862908000199 TPR motif; other site 862908000200 TPR repeat; Region: TPR_11; pfam13414 862908000201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000202 binding surface 862908000203 TPR motif; other site 862908000204 TPR repeat; Region: TPR_11; pfam13414 862908000205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000206 TPR motif; other site 862908000207 binding surface 862908000208 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908000209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000210 binding surface 862908000211 TPR motif; other site 862908000212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908000213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000214 TPR repeat; Region: TPR_11; pfam13414 862908000215 binding surface 862908000216 TPR motif; other site 862908000217 1 probable transmembrane helix predicted for BMS0038 by TMHMM2.0 at aa 279-296 862908000218 HMMPfam hit to PF00515, TPR repeat, score 0.36; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.095 862908000219 HMMPfam hit to PF07719, , score 0.042; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.46 862908000220 HMMPfam hit to PF00515, TPR repeat, score 0.96; HMMPfam hit to PF07719, , score 0.89; PF07719, Tetratricopeptide repeat 862908000221 HMMPfam hit to PF00515, TPR repeat, score 0.17 862908000222 HMMPfam hit to PF07719, , score 1.5; PF07719, Tetratricopeptide repeat 862908000223 HMMPfam hit to PF07719, , score 0.93; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.81 862908000224 HMMPfam hit to PF00515, TPR repeat, score 1.4; HMMPfam hit to PF07719, , score 0.037; PF07719, Tetratricopeptide repeat 862908000225 HMMPfam hit to PF07719, , score 0.48; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.097 862908000226 HMMPfam hit to PF00515, TPR repeat, score 0.0005; HMMPfam hit to PF07719, , score 4.1e-06; PF07719, Tetratricopeptide repeat 862908000227 HMMPfam hit to PF00515, TPR repeat, score 2.1; HMMPfam hit to PF07719, , score 0.46; PF07719, Tetratricopeptide repeat 862908000228 RNA polymerase sigma factor; Provisional; Region: PRK12518 862908000229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908000230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908000231 DNA binding residues [nucleotide binding] 862908000232 HMMPfam hit to PF04542, Sigma-70 region 2, score 5.8e-15 862908000233 PS01063 Sigma-70 factors ECF subfamily signature. 862908000234 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 862908000235 dimer interface [polypeptide binding]; other site 862908000236 Signal peptide predicted for BMS0041 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.990 between residues 47 and 48 862908000237 asparagine synthetase B; Provisional; Region: asnB; PRK09431 862908000238 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862908000239 dimer interface [polypeptide binding]; other site 862908000240 active site 862908000241 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862908000242 Ligand Binding Site [chemical binding]; other site 862908000243 Molecular Tunnel; other site 862908000244 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000245 HMMPfam hit to PF00733, Asparagine synthase, score 2e-82 862908000246 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.7e-06 862908000247 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 862908000248 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 862908000249 putative DNA binding site [nucleotide binding]; other site 862908000250 putative Zn2+ binding site [ion binding]; other site 862908000251 AsnC family; Region: AsnC_trans_reg; pfam01037 862908000252 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 1e-17 862908000253 Response regulator receiver domain; Region: Response_reg; pfam00072 862908000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908000255 active site 862908000256 phosphorylation site [posttranslational modification] 862908000257 intermolecular recognition site; other site 862908000258 dimerization interface [polypeptide binding]; other site 862908000259 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-20 862908000260 4 probable transmembrane helices predicted for BMS0045 by TMHMM2.0 at aa 20-39, 43-61, 68-90 and 100-122 862908000261 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 862908000262 nucleoside/Zn binding site; other site 862908000263 dimer interface [polypeptide binding]; other site 862908000264 catalytic motif [active] 862908000265 HMMPfam hit to PF00383, Cytidine/deoxycytidylate deaminase, zinc-binding region, score 2.1e-39 862908000266 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 862908000267 Signal peptide predicted for BMS0047 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.925 between residues 18 and 19 862908000268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908000269 Coenzyme A binding pocket [chemical binding]; other site 862908000270 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.8e-12 862908000271 Signal peptide predicted for BMS0049 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.975 between residues 41 and 42 862908000272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000273 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 862908000274 Walker A motif; other site 862908000275 ATP binding site [chemical binding]; other site 862908000276 Walker B motif; other site 862908000277 arginine finger; other site 862908000278 HMMPfam hit to PF00004, AAA ATPase, central region, score 1.2e-06 862908000279 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000280 HMMPfam hit to PF02575, Conserved hypothetical protein 103, score 3e-34 862908000281 recombination protein RecR; Reviewed; Region: recR; PRK00076 862908000282 RecR protein; Region: RecR; pfam02132 862908000283 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 862908000284 putative active site [active] 862908000285 putative metal-binding site [ion binding]; other site 862908000286 tetramer interface [polypeptide binding]; other site 862908000287 HMMPfam hit to PF02132, RecR protein, score 0.0005 862908000288 PS01300 RecR protein signature. 862908000289 HMMPfam hit to PF01751, TOPRIM, score 2.2e-07 862908000290 biotin carboxylase-like protein; Validated; Region: PRK06524 862908000291 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 862908000292 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 862908000293 G1 box; other site 862908000294 GTP/Mg2+ binding site [chemical binding]; other site 862908000295 G2 box; other site 862908000296 Switch I region; other site 862908000297 G3 box; other site 862908000298 Switch II region; other site 862908000299 G4 box; other site 862908000300 G5 box; other site 862908000301 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000302 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862908000303 HMMPfam hit to PF00896, Purine phosphorylase, family 2, score 7.3e-91 862908000304 PS01240 Purine and other phosphorylases family 2 signature. 862908000305 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 862908000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908000307 S-adenosylmethionine binding site [chemical binding]; other site 862908000308 HMMPfam hit to PF01795, Bacterial methyltransferase, score 3.6e-119 862908000309 Signal peptide predicted for BMS0058 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.731 between residues 44 and 45 862908000310 1 probable transmembrane helix predicted for BMS0058 by TMHMM2.0 at aa 28-50 862908000311 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 862908000312 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862908000313 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862908000314 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 862908000315 Signal peptide predicted for BMS0059 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.836 between residues 31 and 32 862908000316 1 probable transmembrane helix predicted for BMS0059 by TMHMM2.0 at aa 12-31 862908000317 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.1e-41 862908000318 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 5.6e-68 862908000319 HMMPfam hit to PF03793, PASTA, score 0.00069 862908000320 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 862908000321 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908000322 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862908000323 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 1e-10 862908000324 HMMPfam hit to PF02875, Cytoplasmic peptidoglycan synthetases, C-terminal, score 2e-23 862908000325 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 862908000326 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862908000327 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908000328 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862908000329 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 1.2e-18 862908000330 HMMPfam hit to PF02875, Cytoplasmic peptidoglycan synthetases, C-terminal, score 0.00011 862908000331 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 862908000332 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 862908000333 Mg++ binding site [ion binding]; other site 862908000334 putative catalytic motif [active] 862908000335 putative substrate binding site [chemical binding]; other site 862908000336 10 probable transmembrane helices predicted for BMS0062 by TMHMM2.0 at aa 26-48, 69-91, 97-114, 134-153, 168-190, 197-219, 234-253, 260-282, 287-309 and 336-355 862908000337 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 4.5e-58 862908000338 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 862908000339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908000340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862908000341 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 1.4e-26 862908000342 HMMPfam hit to PF02875, Cytoplasmic peptidoglycan synthetases, C-terminal, score 4.7e-05 862908000343 cell division protein FtsW; Region: ftsW; TIGR02614 862908000344 HMMPfam hit to PF01098, Cell cycle protein, score 8.6e-109 862908000345 10 probable transmembrane helices predicted for BMS0064 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 111-133, 145-160, 164-183, 188-210, 273-295, 307-329 and 339-361 862908000346 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 862908000347 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 862908000348 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862908000349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908000350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862908000351 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 4.3e-57 862908000352 HMMPfam hit to PF02875, Cytoplasmic peptidoglycan synthetases, C-terminal, score 1.1e-21 862908000353 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 862908000354 FAD binding domain; Region: FAD_binding_4; pfam01565 862908000355 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 862908000356 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine reductase, score 4.9e-17 862908000357 Signal peptide predicted for BMS0067 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.317 between residues 23 and 24 862908000358 1 probable transmembrane helix predicted for BMS0067 by TMHMM2.0 at aa 10-32 862908000359 cell division protein FtsA; Region: ftsA; TIGR01174 862908000360 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 862908000361 nucleotide binding site [chemical binding]; other site 862908000362 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 862908000363 Cell division protein FtsA; Region: FtsA; pfam14450 862908000364 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.1e-56 862908000365 HMMPfam hit to PF02491, Cell division protein FtsA, score 3.5e-41 862908000366 cell division protein FtsZ; Validated; Region: PRK09330 862908000367 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 862908000368 nucleotide binding site [chemical binding]; other site 862908000369 SulA interaction site; other site 862908000370 HMMPfam hit to PF00091, Tubulin/FtsZ, GTPase, score 5.6e-84 862908000371 PS01134 FtsZ protein signature 1. 862908000372 PS01135 FtsZ protein signature 2. 862908000373 HMMPfam hit to PF03953, Tubulin/FtsZ, C-terminal, score 1.8e-31 862908000374 Signal peptide predicted for BMS0071 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.835 between residues 32 and 33 862908000375 1 probable transmembrane helix predicted for BMS0071 by TMHMM2.0 at aa 10-32 862908000376 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862908000377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862908000378 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862908000379 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 1.1e-05 862908000380 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.2e-09 862908000381 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 862908000382 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 862908000383 ATP-binding site [chemical binding]; other site 862908000384 Sugar specificity; other site 862908000385 Pyrimidine base specificity; other site 862908000386 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 3.6e-51 862908000387 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000388 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 862908000389 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862908000390 Signal peptide predicted for BMS0075 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.574 between residues 26 and 27 862908000391 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2e-33 862908000392 PS00636 Nt-dnaJ domain signature. 862908000393 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 862908000394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908000395 HMMPfam hit to PF06325, Ribosomal L11 methyltransferase, score 3.5e-19 862908000396 RNA methyltransferase, RsmE family; Region: TIGR00046 862908000397 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 862908000398 HMMPfam hit to PF04452, Protein of unknown function DUF558, score 0.0001 862908000399 RDD family; Region: RDD; pfam06271 862908000400 HMMPfam hit to PF06271, RDD, score 3.7e-08 862908000401 3 probable transmembrane helices predicted for BMS0078 by TMHMM2.0 at aa 138-160, 172-191 and 220-239 862908000402 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 862908000403 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 862908000404 active site 862908000405 nucleotide binding site [chemical binding]; other site 862908000406 HIGH motif; other site 862908000407 KMSKS motif; other site 862908000408 HMMPfam hit to PF01467, Cytidylyltransferase, score 8.1e-15 862908000409 flagellin; Provisional; Region: PRK12802 862908000410 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908000411 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862908000412 HMMPfam hit to PF00669, Flagellin, N-terminal, score 3.6e-46 862908000413 HMMPfam hit to PF00700, Flagellin, C-terminal, score 1.1e-27 862908000414 flagellin; Provisional; Region: PRK12802 862908000415 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908000416 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862908000417 HMMPfam hit to PF00669, Flagellin, N-terminal, score 1.2e-53 862908000418 HMMPfam hit to PF00700, Flagellin, C-terminal, score 4.5e-19 862908000419 PilZ domain; Region: PilZ; pfam07238 862908000420 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 862908000421 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862908000422 putative active site [active] 862908000423 putative metal binding site [ion binding]; other site 862908000424 HMMPfam hit to PF00149, Metallophosphoesterase, score 3.5e-07 862908000425 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 862908000426 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 862908000427 Walker A/P-loop; other site 862908000428 ATP binding site [chemical binding]; other site 862908000429 Q-loop/lid; other site 862908000430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000431 ABC transporter signature motif; other site 862908000432 Walker B; other site 862908000433 D-loop; other site 862908000434 H-loop/switch region; other site 862908000435 HMMPfam hit to PF02463, SMC protein, N-terminal, score 2e-06 862908000436 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000437 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 862908000438 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 862908000439 HMMPfam hit to PF01513, ATP-NAD/AcoX kinase, score 9.3e-54 862908000440 Response regulator receiver domain; Region: Response_reg; pfam00072 862908000441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908000442 active site 862908000443 phosphorylation site [posttranslational modification] 862908000444 intermolecular recognition site; other site 862908000445 dimerization interface [polypeptide binding]; other site 862908000446 HMMPfam hit to PF00072, Response regulator receiver, score 2.3e-11 862908000447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908000448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908000449 ATP binding site [chemical binding]; other site 862908000450 Mg2+ binding site [ion binding]; other site 862908000451 G-X-G motif; other site 862908000452 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.1e-27 862908000453 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.2e-06 862908000454 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862908000455 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862908000456 putative active site [active] 862908000457 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862908000458 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 862908000459 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908000460 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 862908000461 HMMPfam hit to PF02561, Flagellar protein FliS, score 2.2e-27 862908000462 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 862908000463 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 862908000464 HMMPfam hit to PF07195, Flagellar hook-associated 2, C-terminal, score 1e-35 862908000465 HMMPfam hit to PF02465, Flagellar hook-associated protein 2, N-terminal, score 3.4e-09 862908000466 12 probable transmembrane helices predicted for BMS0097 by TMHMM2.0 at aa 19-36, 46-65, 86-108, 112-129, 157-176, 215-237, 250-272, 306-328, 341-363, 383-400, 420-439 and 444-466 862908000467 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 862908000468 active site 862908000469 HMMPfam hit to PF00459, Inositol monophosphatase, score 1.7e-06 862908000470 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908000471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000472 Walker A motif; other site 862908000473 ATP binding site [chemical binding]; other site 862908000474 Walker B motif; other site 862908000475 arginine finger; other site 862908000476 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 7.8e-71 862908000477 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 862908000478 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000479 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 862908000480 FtsJ-like methyltransferase; Region: FtsJ; cl17430 862908000481 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 1.2e-51 862908000482 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 862908000483 Signal peptide predicted for BMS0103 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.529 between residues 29 and 30 862908000484 1 probable transmembrane helix predicted for BMS0103 by TMHMM2.0 at aa 12-31 862908000485 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 3.5e-11 862908000486 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000487 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 862908000488 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862908000489 Catalytic site [active] 862908000490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862908000491 1 probable transmembrane helix predicted for BMS0104 by TMHMM2.0 at aa 20-38 862908000492 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, score 1.1e-23 862908000493 PS00501 Signal peptidases I serine active site. 862908000494 PS00760 Signal peptidases I lysine active site. 862908000495 PS00761 Signal peptidases I signature 3. 862908000496 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 862908000497 MutS domain III; Region: MutS_III; pfam05192 862908000498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000499 Walker A/P-loop; other site 862908000500 ATP binding site [chemical binding]; other site 862908000501 Q-loop/lid; other site 862908000502 ABC transporter signature motif; other site 862908000503 Walker B; other site 862908000504 D-loop; other site 862908000505 H-loop/switch region; other site 862908000506 Smr domain; Region: Smr; pfam01713 862908000507 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 4.4e-09 862908000508 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 5e-10 862908000509 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000510 Domain of unknown function (DUF814); Region: DUF814; pfam05670 862908000511 HMMPfam hit to PF05670, Protein of unknown function DUF814, score 4.7e-08 862908000512 Signal peptide predicted for BMS0108 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.792 between residues 18 and 19 862908000513 Signal peptide predicted for BMS0109 by SignalP 2.0 HMM (Signal peptide probability 0.814) with cleavage site probability 0.785 between residues 21 and 22 862908000514 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000515 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 862908000516 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 862908000517 putative RNA binding site [nucleotide binding]; other site 862908000518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908000519 S-adenosylmethionine binding site [chemical binding]; other site 862908000520 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000521 MoxR-like ATPases [General function prediction only]; Region: COG0714 862908000522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000523 Walker A motif; other site 862908000524 ATP binding site [chemical binding]; other site 862908000525 Walker B motif; other site 862908000526 arginine finger; other site 862908000527 HMMPfam hit to PF07726, , score 1e-81 862908000528 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000529 Protein of unknown function DUF58; Region: DUF58; pfam01882 862908000530 Signal peptide predicted for BMS0113 by SignalP 2.0 HMM (Signal peptide probability 0.918) with cleavage site probability 0.857 between residues 18 and 19 862908000531 1 probable transmembrane helix predicted for BMS0113 by TMHMM2.0 at aa 148-167 862908000532 PS00037 Myb DNA-binding domain repeat signature 1. 862908000533 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862908000534 metal ion-dependent adhesion site (MIDAS); other site 862908000535 This region similar to an operon from Bacteroides fragalis associated wih aerotolerance 862908000536 3 probable transmembrane helices predicted for BMS0114 by TMHMM2.0 at aa 13-30, 50-69 and 301-318 862908000537 HMMPfam hit to PF00092, von Willebrand factor, type A, score 7.9e-30 862908000538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862908000539 metal ion-dependent adhesion site (MIDAS); other site 862908000540 2 probable transmembrane helices predicted for BMS0115 by TMHMM2.0 at aa 5-23 and 296-318 862908000541 HMMPfam hit to PF00092, von Willebrand factor, type A, score 0.00014 862908000542 Oxygen tolerance; Region: BatD; pfam13584 862908000543 Signal peptide predicted for BMS0116 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.845 between residues 31 and 32 862908000544 2 probable transmembrane helices predicted for BMS0116 by TMHMM2.0 at aa 17-39 and 445-467 862908000545 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 862908000546 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 862908000547 active site 862908000548 Riboflavin kinase; Region: Flavokinase; smart00904 862908000549 HMMPfam hit to PF06574, Riboflavin kinase / FAD synthetase, score 7.6e-40 862908000550 HMMPfam hit to PF01687, Riboflavin kinase / FAD synthetase, score 8.9e-52 862908000551 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 862908000552 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 862908000553 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 862908000554 shikimate binding site; other site 862908000555 NAD(P) binding site [chemical binding]; other site 862908000556 HMMPfam hit to PF01488, Shikimate/quinate 5-dehydrogenase, score 5.8e-07 862908000557 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 862908000558 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 862908000559 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 862908000560 Walker A motif; other site 862908000561 ATP binding site [chemical binding]; other site 862908000562 Walker B motif; other site 862908000563 HMMPfam hit to PF05157, General secretory system II, protein E, N-terminal, score 0.00023 862908000564 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 1.5e-117 862908000565 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000566 PS00662 Bacterial type II secretion system protein E signature. 862908000567 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 862908000568 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908000569 Walker A motif; other site 862908000570 ATP binding site [chemical binding]; other site 862908000571 Walker B motif; other site 862908000572 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 3.4e-22 862908000573 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000574 PS00662 Bacterial type II secretion system protein E signature. 862908000575 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 862908000576 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908000577 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908000578 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 4.2e-24 862908000579 PS00874 Bacterial type II secretion system protein F signature. 862908000580 3 probable transmembrane helices predicted for BMS0121 by TMHMM2.0 at aa 172-194, 222-244 and 378-400 862908000581 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 6.3e-22 862908000582 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000583 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 862908000584 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 862908000585 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 862908000586 PS00409 Prokaryotic N-terminal methylation site. 862908000587 HMMPfam hit to PF00114, Fimbrial protein pilin, score 5.7e-07 862908000588 1 probable transmembrane helix predicted for BMS0122 by TMHMM2.0 at aa 10-32 862908000589 1 probable transmembrane helix predicted for BMS0123 by TMHMM2.0 at aa 4-26 862908000590 Signal peptide predicted for BMS0123 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.690 between residues 22 and 23 862908000591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862908000592 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862908000593 Walker A/P-loop; other site 862908000594 ATP binding site [chemical binding]; other site 862908000595 Q-loop/lid; other site 862908000596 ABC transporter signature motif; other site 862908000597 Walker B; other site 862908000598 D-loop; other site 862908000599 H-loop/switch region; other site 862908000600 HMMPfam hit to PF00005, ABC transporter, score 2.3e-47 862908000601 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000602 PS00211 ABC transporters family signature. 862908000603 Signal peptide predicted for BMS0125 by SignalP 2.0 HMM (Signal peptide probability 0.741) with cleavage site probability 0.440 between residues 37 and 38 862908000604 6 probable transmembrane helices predicted for BMS0125 by TMHMM2.0 at aa 20-42, 52-74, 95-117, 132-154, 161-178 and 226-248 862908000605 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000606 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 862908000607 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 862908000608 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 862908000609 Signal peptide predicted for BMS0126 by SignalP 2.0 HMM (Signal peptide probability 0.728) with cleavage site probability 0.606 between residues 21 and 22 862908000610 8 probable transmembrane helices predicted for BMS0126 by TMHMM2.0 at aa 5-24, 45-62, 72-91, 98-120, 124-143, 148-170, 185-214 and 227-246 862908000611 HMMPfam hit to PF06750, Peptidase A24A, N-terminal, score 1.9e-40 862908000612 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 2.9e-12 862908000613 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000614 Competence protein A; Region: Competence_A; pfam11104 862908000615 Cell division protein FtsA; Region: FtsA; pfam14450 862908000616 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 862908000617 HMMPfam hit to PF05137, Fimbrial assembly, score 9.9e-05 862908000618 Pilus assembly protein, PilO; Region: PilO; cl01234 862908000619 Signal peptide predicted for BMS0130 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.588 between residues 17 and 18 862908000620 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 862908000621 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 862908000622 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 862908000623 Signal peptide predicted for BMS0131 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 23 and 24 862908000624 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908000625 HMMPfam hit to PF03958, NolW-like, score 1.2e-11 862908000626 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 3.6e-51 862908000627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908000628 TPR motif; other site 862908000629 binding surface 862908000630 HMMPfam hit to PF07719, , score 0.98; PF07719, Tetratricopeptide repeat 862908000631 HMMPfam hit to PF07719, , score 0.46; PF07719, Tetratricopeptide repeat 862908000632 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 862908000633 Dehydroquinase class II; Region: DHquinase_II; pfam01220 862908000634 trimer interface [polypeptide binding]; other site 862908000635 active site 862908000636 dimer interface [polypeptide binding]; other site 862908000637 HMMPfam hit to PF01220, Dehydroquinase, class II, score 4.5e-47 862908000638 PS01029 Dehydroquinase class II signature. 862908000639 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 862908000640 elongation factor P; Validated; Region: PRK00529 862908000641 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 862908000642 RNA binding site [nucleotide binding]; other site 862908000643 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 862908000644 RNA binding site [nucleotide binding]; other site 862908000645 HMMPfam hit to PF01132, Elongation factor P (EF-P), score 6.7e-69 862908000646 PS01275 Elongation factor P signature. 862908000647 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 862908000648 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862908000649 carboxyltransferase (CT) interaction site; other site 862908000650 biotinylation site [posttranslational modification]; other site 862908000651 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 8.1e-30 862908000652 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862908000653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862908000654 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908000655 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 862908000656 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 4e-52 862908000657 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 5.2e-84 862908000658 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 862908000659 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 2e-51 862908000660 HMMPfam hit to PF07719, , score 2.7; PF07719, Tetratricopeptide repeat 862908000661 HMMPfam hit to PF07719, , score 0.093; PF07719, Tetratricopeptide repeat 862908000662 Family of unknown function (DUF490); Region: DUF490; pfam04357 862908000663 Signal peptide predicted for BMS0139 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.350 between residues 28 and 29 862908000664 1 probable transmembrane helix predicted for BMS0139 by TMHMM2.0 at aa 7-26 862908000665 HMMPfam hit to PF04357, Protein of unknown function DUF490, score 5e-06 862908000666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908000667 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 862908000668 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908000669 Surface antigen; Region: Bac_surface_Ag; pfam01103 862908000670 Signal peptide predicted for BMS0140 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.635 between residues 21 and 22 862908000671 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908000672 HMMPfam hit to PF07244, Surface antigen variable number, score 0.00042 862908000673 HMMPfam hit to PF07244, Surface antigen variable number, score 1.2 862908000674 HMMPfam hit to PF07244, Surface antigen variable number, score 0.2 862908000675 HMMPfam hit to PF07244, Surface antigen variable number, score 0.00021 862908000676 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 8.3e-07 862908000677 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 862908000678 23S rRNA interface [nucleotide binding]; other site 862908000679 L3 interface [polypeptide binding]; other site 862908000680 HMMPfam hit to PF00572, Ribosomal protein L13, score 3.6e-69 862908000681 PS00783 Ribosomal protein L13 signature. 862908000682 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 862908000683 HMMPfam hit to PF00380, Ribosomal protein S9, score 1.9e-54 862908000684 PS00360 Ribosomal protein S9 signature. 862908000685 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 862908000686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000687 Walker A/P-loop; other site 862908000688 ATP binding site [chemical binding]; other site 862908000689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000690 ABC transporter signature motif; other site 862908000691 Walker B; other site 862908000692 D-loop; other site 862908000693 H-loop/switch region; other site 862908000694 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 862908000695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908000696 ABC transporter signature motif; other site 862908000697 Walker B; other site 862908000698 D-loop; other site 862908000699 H-loop/switch region; other site 862908000700 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000701 PS00211 ABC transporters family signature. 862908000702 Signal peptide predicted for BMS0144 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.876 between residues 18 and 19 862908000703 2 probable transmembrane helices predicted for BMS0144 by TMHMM2.0 at aa 5-24 and 222-239 862908000704 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908000705 active site 862908000706 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 862908000707 Signal peptide predicted for BMS0145 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.901 between residues 18 and 19 862908000708 HMMPfam hit to PF00413, Peptidase M10A and M12B, matrixin and adamalysin, score 3.7e-08 862908000709 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908000710 Signal peptide predicted for BMS0146 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 862908000711 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862908000712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000713 Walker A motif; other site 862908000714 ATP binding site [chemical binding]; other site 862908000715 Walker B motif; other site 862908000716 arginine finger; other site 862908000717 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 862908000718 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 1.3e-07 862908000719 HMMPfam hit to PF00004, AAA ATPase, central region, score 9.1e-45 862908000720 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000721 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 6.9e-107 862908000722 PS01046 ATP-dependent serine proteases, lon family, serine active site. 862908000723 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 862908000724 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2.7e-10 862908000725 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 862908000726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862908000727 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 862908000728 acyl-activating enzyme (AAE) consensus motif; other site 862908000729 putative AMP binding site [chemical binding]; other site 862908000730 putative active site [active] 862908000731 putative CoA binding site [chemical binding]; other site 862908000732 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1.5e-69 862908000733 PS00455 Putative AMP-binding domain signature. 862908000734 1 probable transmembrane helix predicted for BMS0152 by TMHMM2.0 at aa 20-42 862908000735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862908000736 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862908000737 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2.6e-64 862908000738 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000739 recombination regulator RecX; Reviewed; Region: recX; PRK00117 862908000740 recombinase A; Provisional; Region: recA; PRK09354 862908000741 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 862908000742 hexamer interface [polypeptide binding]; other site 862908000743 Walker A motif; other site 862908000744 ATP binding site [chemical binding]; other site 862908000745 Walker B motif; other site 862908000746 HMMPfam hit to PF00154, RecA bacterial DNA recombination protein, score 3.1e-234 862908000747 PS00321 recA signature. 862908000748 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000749 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 862908000750 tetramer interfaces [polypeptide binding]; other site 862908000751 binuclear metal-binding site [ion binding]; other site 862908000752 4 probable transmembrane helices predicted for BMS0156 by TMHMM2.0 at aa 12-31, 46-68, 102-119 and 139-161 862908000753 HMMPfam hit to PF04608, Phosphatidylglycerophosphatase A, score 3.3e-25 862908000754 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000755 Signal peptide predicted for BMS0156 by SignalP 2.0 HMM (Signal peptide probability 0.886) with cleavage site probability 0.580 between residues 48 and 49 862908000756 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 862908000757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862908000758 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 862908000759 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 1.2e-17 862908000760 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 862908000761 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 862908000762 ssDNA binding site; other site 862908000763 generic binding surface II; other site 862908000764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908000765 ATP binding site [chemical binding]; other site 862908000766 putative Mg++ binding site [ion binding]; other site 862908000767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908000768 nucleotide binding region [chemical binding]; other site 862908000769 ATP-binding site [chemical binding]; other site 862908000770 HMMPfam hit to PF00271, Helicase, C-terminal, score 6.1e-20 862908000771 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 1.2e-27 862908000772 PS00435 Peroxidases proximal heme-ligand signature. 862908000773 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000774 PS00284 Serpins signature. 862908000775 HMMPfam hit to PF01336, OB-fold nucleic acid binding, score 0.12 862908000776 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 862908000777 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862908000778 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862908000779 HMMPfam hit to PF01272, Prokaryotic transcription elongation factor GreA/GreB, score 5.4e-24 862908000780 PS00830 Prokaryotic transcription elongation factors signature 2. 862908000781 HMMPfam hit to PF03449, Prokaryotic transcription elongation factor GreA/GreB, score 3.3e-34 862908000782 1 probable transmembrane helix predicted for BMS0164 by TMHMM2.0 at aa 15-37 862908000783 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 862908000784 ABC1 family; Region: ABC1; pfam03109 862908000785 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 862908000786 active site 862908000787 ATP binding site [chemical binding]; other site 862908000788 HMMPfam hit to PF03109, ABC-1, score 1.5e-40 862908000789 2 probable transmembrane helices predicted for BMS0166 by TMHMM2.0 at aa 512-534 and 541-563 862908000790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862908000791 flagellin; Provisional; Region: PRK12802 862908000792 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908000793 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862908000794 HMMPfam hit to PF00669, Flagellin, N-terminal, score 1.2e-49 862908000795 HMMPfam hit to PF00700, Flagellin, C-terminal, score 1.9e-27 862908000796 flagellin; Provisional; Region: PRK12802 862908000797 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908000798 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862908000799 HMMPfam hit to PF00669, Flagellin, N-terminal, score 2.3e-51 862908000800 HMMPfam hit to PF00700, Flagellin, C-terminal, score 4.6e-29 862908000801 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 862908000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908000803 NAD(P) binding site [chemical binding]; other site 862908000804 active site 862908000805 Flp/Fap pilin component; Region: Flp_Fap; cl01585 862908000806 1 probable transmembrane helix predicted for BMS0172 by TMHMM2.0 at aa 15-34 862908000807 1 probable transmembrane helix predicted for BMS0173 by TMHMM2.0 at aa 13-35 862908000808 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 0.00034 862908000809 4 probable transmembrane helices predicted for BMS0174 by TMHMM2.0 at aa 26-45, 50-72, 97-119 and 140-162 862908000810 1 probable transmembrane helix predicted for BMS0175 by TMHMM2.0 at aa 15-37 862908000811 1 probable transmembrane helix predicted for BMS0176 by TMHMM2.0 at aa 4-26 862908000812 1 probable transmembrane helix predicted for BMS0177 by TMHMM2.0 at aa 21-43 862908000813 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 862908000814 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 862908000815 Signal peptide predicted for BMS0178 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.925 between residues 22 and 23 862908000816 1 probable transmembrane helix predicted for BMS0178 by TMHMM2.0 at aa 5-24 862908000817 HMMPfam hit to PF06981, Flp pilus assembly CpaB, score 2.8e-12 862908000818 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 862908000819 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 1.3e-09 862908000820 AAA domain; Region: AAA_31; pfam13614 862908000821 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 862908000822 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 862908000823 ATP binding site [chemical binding]; other site 862908000824 Walker A motif; other site 862908000825 hexamer interface [polypeptide binding]; other site 862908000826 Walker B motif; other site 862908000827 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000828 PS00191 Cytochrome b5 family, heme-binding domain signature. 862908000829 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000830 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 4.8e-102 862908000831 PS00227 Tubulin subunits alpha, beta, and gamma signature. 862908000832 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000833 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 862908000834 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908000835 5 probable transmembrane helices predicted for BMS0181 by TMHMM2.0 at aa 4-26, 63-85, 89-111, 233-255 and 270-292 862908000836 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908000837 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 1.6e-12 862908000838 Signal peptide predicted for BMS0182 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.941 between residues 19 and 20 862908000839 HMMPfam hit to PF05593, YD repeat, score 2 862908000840 HMMPfam hit to PF05593, YD repeat, score 3.1 862908000841 HMMPfam hit to PF05593, YD repeat, score 1.1 862908000842 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000843 HMMPfam hit to PF05593, YD repeat, score 3.4 862908000844 Signal peptide predicted for BMS0183 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 862908000845 Signal peptide predicted for BMS0184 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.966 between residues 22 and 23 862908000846 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 862908000847 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908000848 NAD(P) binding site [chemical binding]; other site 862908000849 catalytic residues [active] 862908000850 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.5e-36 862908000851 PS00687 Aldehyde dehydrogenases glutamic acid active site. 862908000852 PS00070 Aldehyde dehydrogenases cysteine active site. 862908000853 Signal peptide predicted for BMS0186 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 20 and 21 862908000854 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908000856 active site 862908000857 phosphorylation site [posttranslational modification] 862908000858 intermolecular recognition site; other site 862908000859 dimerization interface [polypeptide binding]; other site 862908000860 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-25 862908000861 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 862908000862 7 probable transmembrane helices predicted for BMS0190 by TMHMM2.0 at aa 40-62, 89-108, 123-145, 157-179, 220-237, 244-266 and 276-293 862908000863 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862908000864 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862908000865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908000866 Walker A motif; other site 862908000867 ATP binding site [chemical binding]; other site 862908000868 Walker B motif; other site 862908000869 arginine finger; other site 862908000870 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 862908000871 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 2.8e-125 862908000872 PS01046 ATP-dependent serine proteases, lon family, serine active site. 862908000873 HMMPfam hit to PF00004, AAA ATPase, central region, score 3.3e-47 862908000874 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000875 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 2.4e-33 862908000876 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 862908000877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908000878 active site 862908000879 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 862908000880 active site 862908000881 substrate binding site [chemical binding]; other site 862908000882 CoA binding site [chemical binding]; other site 862908000883 HMMPfam hit to PF00483, Nucleotidyl transferase, score 7.8e-09 862908000884 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 21 862908000885 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.081 862908000886 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 49 862908000887 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 22 862908000888 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 69 862908000889 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 8.4 862908000890 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 862908000891 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 862908000892 glutaminase active site [active] 862908000893 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 862908000894 dimer interface [polypeptide binding]; other site 862908000895 active site 862908000896 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 862908000897 dimer interface [polypeptide binding]; other site 862908000898 active site 862908000899 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 3.3e-48 862908000900 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.1e-15 862908000901 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 6.3e-16 862908000902 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 862908000903 Part of AAA domain; Region: AAA_19; pfam13245 862908000904 Family description; Region: UvrD_C_2; pfam13538 862908000905 HMMPfam hit to PF00580, UvrD/REP helicase, score 6.1e-179 862908000906 PS00017 ATP/GTP-binding site motif A (P-loop). 862908000907 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 862908000908 Signal peptide predicted for BMS0196 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.919 between residues 28 and 29 862908000909 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 862908000910 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 862908000911 HMMPfam hit to PF01008, Initiation factor 2B, score 1.9e-78 862908000912 exopolyphosphatase; Region: exo_poly_only; TIGR03706 862908000913 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 862908000914 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 3.9e-23 862908000915 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908000916 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908000917 ligand binding site [chemical binding]; other site 862908000918 flexible hinge region; other site 862908000919 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 9.9e-23 862908000920 FliG C-terminal domain; Region: FliG_C; pfam01706 862908000921 major vault protein; Provisional; Region: PTZ00491 862908000922 putative acyltransferase; Provisional; Region: PRK05790 862908000923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862908000924 dimer interface [polypeptide binding]; other site 862908000925 active site 862908000926 HMMPfam hit to PF00108, Thiolase, score 3.4e-94 862908000927 PS00098 Thiolases acyl-enzyme intermediate signature. 862908000928 HMMPfam hit to PF02803, Thiolase, score 2.9e-63 862908000929 PS00737 Thiolases signature 2. 862908000930 PS00099 Thiolases active site. 862908000931 1 probable transmembrane helix predicted for BMS0203 by TMHMM2.0 at aa 207-226 862908000932 Signal peptide predicted for BMS0204 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.506 between residues 26 and 27 862908000933 4 probable transmembrane helices predicted for BMS0205 by TMHMM2.0 at aa 7-26, 36-58, 108-127 and 137-159 862908000934 Putative RNA methyltransferase; Region: Methyltrn_RNA_3; cl12077 862908000935 HEAT repeats; Region: HEAT_2; pfam13646 862908000936 HEAT repeats; Region: HEAT_2; pfam13646 862908000937 1 probable transmembrane helix predicted for BMS0206 by TMHMM2.0 at aa 30-52 862908000938 HMMPfam hit to PF02985, HEAT, score 0.38 862908000939 HMMPfam hit to PF02985, HEAT, score 4.4 862908000940 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 862908000941 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862908000942 iron-sulfur cluster [ion binding]; other site 862908000943 [2Fe-2S] cluster binding site [ion binding]; other site 862908000944 Signal peptide predicted for BMS0207 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.284 between residues 38 and 39 862908000945 1 probable transmembrane helix predicted for BMS0207 by TMHMM2.0 at aa 13-35 862908000946 HMMPfam hit to PF00355, Rieske [2Fe-2S] region, score 1.2e-11 862908000947 PS00199 Rieske iron-sulfur protein signature 1. 862908000948 PS00200 Rieske iron-sulfur protein signature 2. 862908000949 interchain domain interface [polypeptide binding]; other site 862908000950 intrachain domain interface; other site 862908000951 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862908000952 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 862908000953 heme bH binding site [chemical binding]; other site 862908000954 Qi binding site; other site 862908000955 heme bL binding site [chemical binding]; other site 862908000956 Qo binding site; other site 862908000957 HMMPfam hit to PF00033, Cytochrome b/b6, N-terminal, score 2.3e-23 862908000958 4 probable transmembrane helices predicted for BMS0208 by TMHMM2.0 at aa 59-81, 112-129, 142-164 and 223-245 862908000959 8 probable transmembrane helices predicted for BMS0209 by TMHMM2.0 at aa 15-32, 37-59, 69-86, 118-140, 171-193, 214-236, 280-302 and 322-344 862908000960 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 862908000961 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862908000962 Cytochrome c; Region: Cytochrom_C; pfam00034 862908000963 1 probable transmembrane helix predicted for BMS0210 by TMHMM2.0 at aa 19-36 862908000964 PS00190 Cytochrome c family heme-binding site signature. 862908000965 PS00190 Cytochrome c family heme-binding site signature. 862908000966 PS00190 Cytochrome c family heme-binding site signature. 862908000967 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 862908000968 PS00190 Cytochrome c family heme-binding site signature. 862908000969 HMMPfam hit to PF00034, Cytochrome c, class I, score 0.0058 862908000970 PS00190 Cytochrome c family heme-binding site signature. 862908000971 PS00215 Mitochondrial energy transfer proteins signature. 862908000972 PS00190 Cytochrome c family heme-binding site signature. 862908000973 PS00190 Cytochrome c family heme-binding site signature. 862908000974 PS00190 Cytochrome c family heme-binding site signature. 862908000975 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 862908000976 Subunit I/III interface [polypeptide binding]; other site 862908000977 HMMPfam hit to PF00510, Cytochrome c oxidase, subunit III, score 3.2e-10 862908000978 5 probable transmembrane helices predicted for BMS0211 by TMHMM2.0 at aa 32-54, 69-91, 103-125, 145-167 and 187-209 862908000979 1 probable transmembrane helix predicted for BMS0212 by TMHMM2.0 at aa 10-28 862908000980 Protein of unknown function (DUF420); Region: DUF420; pfam04238 862908000981 5 probable transmembrane helices predicted for BMS0213 by TMHMM2.0 at aa 13-32, 47-69, 76-98, 118-140 and 153-175 862908000982 HMMPfam hit to PF04238, Protein of unknown function DUF420, score 3.9e-37 862908000983 Signal peptide predicted for BMS0214 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 36 and 37 862908000984 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908000985 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 862908000986 HMMPfam hit to PF03301, Tryptophan 2,3-dioxygenase, score 1.2e-101 862908000987 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 862908000988 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 862908000989 HMMPfam hit to PF02628, Cytochrome oxidase assembly, score 9.5e-09 862908000990 Signal peptide predicted for BMS0217 by SignalP 2.0 HMM (Signal peptide probability 0.619) with cleavage site probability 0.276 between residues 39 and 40 862908000991 8 probable transmembrane helices predicted for BMS0217 by TMHMM2.0 at aa 13-35, 82-104, 117-139, 144-166, 187-206, 231-250, 263-285 and 295-314 862908000992 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 862908000993 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 862908000994 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 862908000995 UbiA prenyltransferase family; Region: UbiA; pfam01040 862908000996 HMMPfam hit to PF02628, Cytochrome oxidase assembly, score 1.1e-06 862908000997 17 probable transmembrane helices predicted for BMS0218 by TMHMM2.0 at aa 7-29, 54-73, 85-107, 112-134, 164-186, 224-246, 258-280, 284-306, 337-356, 360-382, 403-425, 429-448, 455-474, 484-506, 530-547, 552-574 and 587-606 862908000998 HMMPfam hit to PF01040, UbiA prenyltransferase, score 2.3e-52 862908000999 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 862908001000 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 862908001001 2 probable transmembrane helices predicted for BMS0219 by TMHMM2.0 at aa 40-62 and 82-101 862908001002 HMMPfam hit to PF00116, Cytochrome c oxidase, subunit II, score 9.6e-14 862908001003 PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 862908001004 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 862908001005 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 862908001006 HMMPfam hit to PF00115, Cytochrome c oxidase, subunit I, score 2.1e-167 862908001007 14 probable transmembrane helices predicted for BMS0220 by TMHMM2.0 at aa 32-54, 87-109, 121-143, 147-169, 176-198, 213-235, 242-264, 268-287, 299-321, 336-358, 371-393, 408-430, 443-465 and 485-507 862908001008 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 862908001009 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 862908001010 Subunit I/III interface [polypeptide binding]; other site 862908001011 Signal peptide predicted for BMS0221 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.472 between residues 37 and 38 862908001012 HMMPfam hit to PF00510, Cytochrome c oxidase, subunit III, score 0.0017 862908001013 5 probable transmembrane helices predicted for BMS0221 by TMHMM2.0 at aa 21-43, 63-83, 96-116, 136-158 and 179-196 862908001014 Cytochrome c; Region: Cytochrom_C; cl11414 862908001015 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862908001016 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862908001017 Signal peptide predicted for BMS0222 by SignalP 2.0 HMM (Signal peptide probability 0.883) with cleavage site probability 0.543 between residues 21 and 22 862908001018 HMMPfam hit to PF00034, Cytochrome c, class I, score 0.0055 862908001019 PS00190 Cytochrome c family heme-binding site signature. 862908001020 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 862908001021 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 862908001022 Cu(I) binding site [ion binding]; other site 862908001023 1 probable transmembrane helix predicted for BMS0223 by TMHMM2.0 at aa 13-35 862908001024 HMMPfam hit to PF02630, Electron transport protein SCO1/SenC, score 1.2e-10 862908001025 3 probable transmembrane helices predicted for BMS0224 by TMHMM2.0 at aa 12-31, 36-58 and 71-88 862908001026 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862908001027 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862908001028 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.1e-06 862908001029 1 probable transmembrane helix predicted for BMS0225 by TMHMM2.0 at aa 9-31 862908001030 Signal peptide predicted for BMS0225 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 862908001031 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 862908001032 active site 862908001033 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin type, score 2.2e-35 862908001034 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 862908001035 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 862908001036 Signal peptide predicted for BMS0228 by SignalP 2.0 HMM (Signal peptide probability 0.680) with cleavage site probability 0.582 between residues 27 and 28 862908001037 5 probable transmembrane helices predicted for BMS0228 by TMHMM2.0 at aa 5-27, 47-81, 94-116, 126-145 and 459-481 862908001038 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE protein, score 4e-71 862908001039 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001040 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 862908001041 rRNA interaction site [nucleotide binding]; other site 862908001042 S8 interaction site; other site 862908001043 putative laminin-1 binding site; other site 862908001044 PS00962 Ribosomal protein S2 signature 1. 862908001045 HMMPfam hit to PF00318, Ribosomal protein S2, score 5.7e-97 862908001046 PS00963 Ribosomal protein S2 signature 2. 862908001047 elongation factor Ts; Provisional; Region: tsf; PRK09377 862908001048 UBA/TS-N domain; Region: UBA; pfam00627 862908001049 Elongation factor TS; Region: EF_TS; pfam00889 862908001050 Elongation factor TS; Region: EF_TS; pfam00889 862908001051 HMMPfam hit to PF00627, Ubiquitin-associated, score 7.7e-14 862908001052 PS01126 Elongation factor Ts signature 1. 862908001053 HMMPfam hit to PF00889, Elongation factor Ts, score 1.2e-69 862908001054 PS01127 Elongation factor Ts signature 2. 862908001055 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 862908001056 putative nucleotide binding site [chemical binding]; other site 862908001057 uridine monophosphate binding site [chemical binding]; other site 862908001058 homohexameric interface [polypeptide binding]; other site 862908001059 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.2e-58 862908001060 ribosome recycling factor; Reviewed; Region: frr; PRK00083 862908001061 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 862908001062 hinge region; other site 862908001063 HMMPfam hit to PF01765, Ribosome recycling factor, score 3e-84 862908001064 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 862908001065 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 862908001066 catalytic residue [active] 862908001067 putative FPP diphosphate binding site; other site 862908001068 putative FPP binding hydrophobic cleft; other site 862908001069 dimer interface [polypeptide binding]; other site 862908001070 putative IPP diphosphate binding site; other site 862908001071 HMMPfam hit to PF01255, Di-trans-poly-cis-decaprenylcistransferase, score 3.7e-89 862908001072 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 862908001073 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 862908001074 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 862908001075 Signal peptide predicted for BMS0234 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.807 between residues 31 and 32 862908001076 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 8.4e-48 862908001077 8 probable transmembrane helices predicted for BMS0234 by TMHMM2.0 at aa 12-41, 56-75, 80-102, 117-136, 141-163, 183-203, 210-227 and 256-273 862908001078 PS01315 Phosphatidate cytidylyltransferase signature. 862908001079 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862908001080 active site 862908001081 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 862908001082 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 862908001083 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862908001084 putative substrate binding region [chemical binding]; other site 862908001085 4 probable transmembrane helices predicted for BMS0235 by TMHMM2.0 at aa 5-27, 98-120, 447-469 and 497-519 862908001086 HMMPfam hit to PF02163, Peptidase M50, score 1.1e-63 862908001087 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908001088 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 0.0061 862908001089 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 862908001090 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 862908001091 Signal peptide predicted for BMS0237 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.765 between residues 33 and 34 862908001092 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 862908001093 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 862908001094 5 probable transmembrane helices predicted for BMS0238 by TMHMM2.0 at aa 28-50, 113-130, 150-172, 177-199 and 212-234 862908001095 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 2.5e-22 862908001096 PS00379 CDP-alcohol phosphatidyltransferases signature. 862908001097 Signal peptide predicted for BMS0239 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 30 and 31 862908001098 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 862908001099 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 862908001100 dimerization interface 3.5A [polypeptide binding]; other site 862908001101 active site 862908001102 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.4e-23 862908001103 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 9.4e-05 862908001104 trigger factor; Region: tig; TIGR00115 862908001105 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 862908001106 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 862908001107 HMMPfam hit to PF05697, Bacterial trigger factor, N-terminal, score 4.6e-40 862908001108 HMMPfam hit to PF00254, Peptidylprolyl isomerase, FKBP-type, score 1.1e-17 862908001109 HMMPfam hit to PF05698, Bacterial trigger factor, C-terminal, score 1.4e-35 862908001110 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 862908001111 HMMPfam hit to PF04209, Homogentisate 1,2-dioxygenase, score 6.4e-38 862908001112 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862908001113 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 862908001114 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase, score 3.3e-27 862908001115 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908001116 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 862908001117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862908001118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908001119 homodimer interface [polypeptide binding]; other site 862908001120 catalytic residue [active] 862908001121 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.7e-22 862908001122 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 862908001123 Domain of unknown function (DUF309); Region: DUF309; pfam03745 862908001124 HMMPfam hit to PF03745, Protein of unknown function DUF309, score 1.8e-13 862908001125 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 862908001126 4 probable transmembrane helices predicted for BMS0248 by TMHMM2.0 at aa 24-46, 74-96, 145-167 and 212-234 862908001127 HMMPfam hit to PF04401, Protein of unknown function DUF540, score 1.1e-12 862908001128 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908001129 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 862908001130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908001131 active site 862908001132 HIGH motif; other site 862908001133 nucleotide binding site [chemical binding]; other site 862908001134 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862908001135 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862908001136 active site 862908001137 KMSKS motif; other site 862908001138 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 862908001139 tRNA binding surface [nucleotide binding]; other site 862908001140 anticodon binding site; other site 862908001141 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 862908001142 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 1.7e-231 862908001143 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 862908001144 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 862908001145 Signal peptide predicted for BMS0252 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.946 between residues 19 and 20 862908001146 Signal peptide predicted for BMS0253 by SignalP 2.0 HMM (Signal peptide probability 0.853) with cleavage site probability 0.848 between residues 17 and 18 862908001147 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 862908001148 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862908001149 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862908001150 Cysteine-rich domain; Region: CCG; pfam02754 862908001151 Cysteine-rich domain; Region: CCG; pfam02754 862908001152 HMMPfam hit to PF02754, Protein of unknown function DUF224, score 6.9e-15 862908001153 HMMPfam hit to PF02754, Protein of unknown function DUF224, score 1e-09 862908001154 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.00056 862908001155 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908001156 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.0023 862908001157 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908001158 5 probable transmembrane helices predicted for BMS0256 by TMHMM2.0 at aa 20-37, 84-106, 119-141, 161-183 and 216-238 862908001159 5 probable transmembrane helices predicted for BMS0257 by TMHMM2.0 at aa 5-24, 36-55, 59-78, 99-121 and 146-168 862908001160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 862908001161 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 862908001162 dimerization interface [polypeptide binding]; other site 862908001163 domain crossover interface; other site 862908001164 redox-dependent activation switch; other site 862908001165 HMMPfam hit to PF01430, Hsp33 protein, score 1.2e-05 862908001166 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 862908001167 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 862908001168 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 862908001169 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.4e-13 862908001170 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001171 PS00422 Granins signature 1. 862908001172 Signal peptide predicted for BMS0262 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 862908001173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908001174 Signal peptide predicted for BMS0263 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.544 between residues 26 and 27 862908001175 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908001176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908001177 TPR motif; other site 862908001178 binding surface 862908001179 Signal peptide predicted for BMS0264 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.990 between residues 26 and 27 862908001180 HMMPfam hit to PF07719, , score 0.21; PF07719, Tetratricopeptide repeat 862908001181 HMMPfam hit to PF07719, , score 0.3; PF07719, Tetratricopeptide repeat 862908001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908001183 TPR motif; other site 862908001184 binding surface 862908001185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908001186 binding surface 862908001187 TPR motif; other site 862908001188 Signal peptide predicted for BMS0265 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.488 between residues 20 and 21 862908001189 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908001190 HMMPfam hit to PF07719, , score 0.028; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.012 862908001191 HMMPfam hit to PF00515, TPR repeat, score 0.01; HMMPfam hit to PF07719, , score 0.19; PF07719, Tetratricopeptide repeat 862908001192 Signal peptide predicted for BMS0266 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.941 between residues 19 and 20 862908001193 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908001194 phosphopeptide binding site; other site 862908001195 HMMPfam hit to PF00498, Forkhead-associated, score 4e-10 862908001196 1 probable transmembrane helix predicted for BMS0267 by TMHMM2.0 at aa 333-352 862908001197 HMMPfam hit to PF04023, FeoA, score 9.9e-13 862908001198 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 862908001199 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862908001200 G1 box; other site 862908001201 GTP/Mg2+ binding site [chemical binding]; other site 862908001202 G2 box; other site 862908001203 Switch I region; other site 862908001204 G3 box; other site 862908001205 Switch II region; other site 862908001206 G4 box; other site 862908001207 G5 box; other site 862908001208 Nucleoside recognition; Region: Gate; pfam07670 862908001209 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 862908001210 Nucleoside recognition; Region: Gate; pfam07670 862908001211 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.1e-19 862908001212 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001213 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 4.8e-30 862908001214 7 probable transmembrane helices predicted for BMS0269 by TMHMM2.0 at aa 242-264, 303-325, 381-403, 423-445, 483-500, 599-621 and 634-653 862908001215 HMMPfam hit to PF07670, , score 5.9e-14 862908001216 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908001217 HMMPfam hit to PF07664, , score 1.6e-07 862908001218 HMMPfam hit to PF07670, , score 5.7e-14 862908001219 5 probable transmembrane helices predicted for BMS0270 by TMHMM2.0 at aa 13-30, 40-57, 99-121, 127-144 and 151-173 862908001220 1 probable transmembrane helix predicted for BMS0271 by TMHMM2.0 at aa 22-39 862908001221 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 862908001222 1 probable transmembrane helix predicted for BMS0272 by TMHMM2.0 at aa 20-42 862908001223 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 862908001224 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 1.9e-08 862908001225 3 probable transmembrane helices predicted for BMS0273 by TMHMM2.0 at aa 15-37, 126-148 and 168-190 862908001226 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 862908001227 dimer interface [polypeptide binding]; other site 862908001228 active site 862908001229 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.4e-06 862908001230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862908001231 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862908001232 catalytic residues [active] 862908001233 HMMPfam hit to PF00085, Thioredoxin-related, score 9.6e-41 862908001234 PS00194 Thioredoxin family active site. 862908001235 RDD family; Region: RDD; pfam06271 862908001236 HMMPfam hit to PF06271, RDD, score 9.1e-05 862908001237 2 probable transmembrane helices predicted for BMS0276 by TMHMM2.0 at aa 26-48 and 95-117 862908001238 DNA polymerase I; Provisional; Region: PRK05755 862908001239 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 862908001240 active site 862908001241 metal binding site 1 [ion binding]; metal-binding site 862908001242 putative 5' ssDNA interaction site; other site 862908001243 metal binding site 3; metal-binding site 862908001244 metal binding site 2 [ion binding]; metal-binding site 862908001245 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 862908001246 putative DNA binding site [nucleotide binding]; other site 862908001247 putative metal binding site [ion binding]; other site 862908001248 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862908001249 active site 862908001250 substrate binding site [chemical binding]; other site 862908001251 catalytic site [active] 862908001252 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 862908001253 active site 862908001254 DNA binding site [nucleotide binding] 862908001255 catalytic site [active] 862908001256 HMMPfam hit to PF02739, 5'-3' exonuclease, score 1e-56 862908001257 HMMPfam hit to PF01367, 5'-3' exonuclease, score 7.1e-28 862908001258 HMMPfam hit to PF00476, DNA-directed DNA polymerase, score 5.8e-154 862908001259 PS00447 DNA polymerase family A signature. 862908001260 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908001261 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908001262 catalytic residue [active] 862908001263 Signal peptide predicted for BMS0279 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.895 between residues 19 and 20 862908001264 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 862908001265 oligomerisation interface [polypeptide binding]; other site 862908001266 mobile loop; other site 862908001267 roof hairpin; other site 862908001268 HMMPfam hit to PF00166, Chaperonin Cpn10, score 1.5e-51 862908001269 PS00681 Chaperonins cpn10 signature. 862908001270 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862908001271 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862908001272 ring oligomerisation interface [polypeptide binding]; other site 862908001273 ATP/Mg binding site [chemical binding]; other site 862908001274 stacking interactions; other site 862908001275 hinge regions; other site 862908001276 HMMPfam hit to PF00118, Chaperonin Cpn60/TCP-1, score 1.9e-203 862908001277 PS00296 Chaperonins cpn60 signature. 862908001278 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 862908001279 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 862908001280 Cl- selectivity filter; other site 862908001281 Cl- binding residues [ion binding]; other site 862908001282 pore gating glutamate residue; other site 862908001283 dimer interface [polypeptide binding]; other site 862908001284 FOG: CBS domain [General function prediction only]; Region: COG0517 862908001285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 862908001286 9 probable transmembrane helices predicted for BMS0282 by TMHMM2.0 at aa 27-49, 59-81, 158-180, 190-212, 232-254, 269-291, 298-320, 335-357 and 369-391 862908001287 HMMPfam hit to PF00654, Cl- channel, voltage gated, score 1.8e-56 862908001288 HMMPfam hit to PF00571, CBS, score 3.4e-08 862908001289 HMMPfam hit to PF00571, CBS, score 5.9e-09 862908001290 Protein of unknown function, DUF481; Region: DUF481; pfam04338 862908001291 Signal peptide predicted for BMS0283 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.960 between residues 29 and 30 862908001292 mechanosensitive channel MscS; Provisional; Region: PRK10334 862908001293 Conserved TM helix; Region: TM_helix; pfam05552 862908001294 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908001295 3 probable transmembrane helices predicted for BMS0284 by TMHMM2.0 at aa 17-39, 60-82 and 97-119 862908001296 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.4e-60 862908001297 Domain of unknown function (DUF955); Region: DUF955; cl01076 862908001298 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908001299 Signal peptide predicted for BMS0285 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.973 between residues 18 and 19 862908001300 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 862908001301 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862908001302 Catalytic site [active] 862908001303 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862908001304 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, score 5.9e-19 862908001305 PS00760 Signal peptidases I lysine active site. 862908001306 PS00761 Signal peptidases I signature 3. 862908001307 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 862908001308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862908001309 N-terminal plug; other site 862908001310 ligand-binding site [chemical binding]; other site 862908001311 Signal peptide predicted for BMS0289 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.894 between residues 17 and 18 862908001312 HMMPfam hit to PF07715, , score 6e-22 862908001313 HMMPfam hit to PF00593, TonB-dependent receptor, score 1.3e-23 862908001314 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 862908001315 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 862908001316 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 0.00015 862908001317 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862908001318 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 862908001319 intersubunit interface [polypeptide binding]; other site 862908001320 Signal peptide predicted for BMS0291 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.605 between residues 17 and 18 862908001321 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.5e-06 862908001322 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862908001323 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862908001324 Walker A/P-loop; other site 862908001325 ATP binding site [chemical binding]; other site 862908001326 Q-loop/lid; other site 862908001327 ABC transporter signature motif; other site 862908001328 Walker B; other site 862908001329 D-loop; other site 862908001330 H-loop/switch region; other site 862908001331 HMMPfam hit to PF00005, ABC transporter, score 3e-41 862908001332 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001333 PS00211 ABC transporters family signature. 862908001334 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862908001335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862908001336 ABC-ATPase subunit interface; other site 862908001337 dimer interface [polypeptide binding]; other site 862908001338 putative PBP binding regions; other site 862908001339 Signal peptide predicted for BMS0293 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.496 between residues 21 and 22 862908001340 9 probable transmembrane helices predicted for BMS0293 by TMHMM2.0 at aa 5-23, 43-65, 72-94, 99-121, 133-155, 175-197, 227-249, 264-281 and 293-312 862908001341 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 1.4e-69 862908001342 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862908001343 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 862908001344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908001345 dimer interface [polypeptide binding]; other site 862908001346 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862908001347 putative CheW interface [polypeptide binding]; other site 862908001348 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.5e-37 862908001349 2 probable transmembrane helices predicted for BMS0295 by TMHMM2.0 at aa 15-37 and 197-219 862908001350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908001351 S-adenosylmethionine binding site [chemical binding]; other site 862908001352 Signal peptide predicted for BMS0298 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.428 between residues 17 and 18 862908001353 Signal peptide predicted for BMS0299 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.905 between residues 18 and 19 862908001354 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862908001355 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862908001356 Signal peptide predicted for BMS0300 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 22 and 23 862908001357 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.6e-70 862908001358 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 862908001359 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 862908001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908001361 dimer interface [polypeptide binding]; other site 862908001362 conserved gate region; other site 862908001363 putative PBP binding loops; other site 862908001364 ABC-ATPase subunit interface; other site 862908001365 Signal peptide predicted for BMS0301 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.848 between residues 25 and 26 862908001366 6 probable transmembrane helices predicted for BMS0301 by TMHMM2.0 at aa 5-27, 120-142, 162-184, 210-232, 267-289 and 317-339 862908001367 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.7e-46 862908001368 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908001369 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 862908001370 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862908001371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908001372 dimer interface [polypeptide binding]; other site 862908001373 conserved gate region; other site 862908001374 putative PBP binding loops; other site 862908001375 ABC-ATPase subunit interface; other site 862908001376 Signal peptide predicted for BMS0302 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.496 between residues 45 and 46 862908001377 6 probable transmembrane helices predicted for BMS0302 by TMHMM2.0 at aa 23-45, 145-167, 180-197, 201-220, 252-274 and 304-326 862908001378 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.2e-48 862908001379 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908001380 Signal peptide predicted for BMS0303 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.560 between residues 19 and 20 862908001381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908001382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862908001383 protein binding site [polypeptide binding]; other site 862908001384 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 0.059 862908001385 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 2.7e-18 862908001386 Signal peptide predicted for BMS0304 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.848 between residues 21 and 22 862908001387 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 862908001388 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase-related, score 2.6e-50 862908001389 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 862908001390 putative catalytic site [active] 862908001391 putative metal binding site [ion binding]; other site 862908001392 putative phosphate binding site [ion binding]; other site 862908001393 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 1.8e-18 862908001394 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 862908001395 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 862908001396 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 862908001397 substrate binding pocket [chemical binding]; other site 862908001398 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 862908001399 B12 binding site [chemical binding]; other site 862908001400 cobalt ligand [ion binding]; other site 862908001401 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 862908001402 HMMPfam hit to PF02965, Vitamin B12 dependent methionine synthase, activation region, score 7.3e-125 862908001403 HMMPfam hit to PF02310, Coenzyme B12-binding, score 1.3e-25 862908001404 HMMPfam hit to PF02607, Cobalamin-dependent methionine synthase, B12-binding, score 3.4e-42 862908001405 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 2.6e-57 862908001406 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 6.8e-127 862908001407 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 862908001408 FAD binding site [chemical binding]; other site 862908001409 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 3.3e-44 862908001410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908001411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908001412 ATP binding site [chemical binding]; other site 862908001413 Mg2+ binding site [ion binding]; other site 862908001414 G-X-G motif; other site 862908001415 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.2e-20 862908001416 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 862908001417 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 862908001418 active site 862908001419 metal binding site [ion binding]; metal-binding site 862908001420 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862908001421 Signal peptide predicted for BMS0314 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.504 between residues 20 and 21 862908001422 HMMPfam hit to PF00149, Metallophosphoesterase, score 9e-18 862908001423 PS00785 5'-nucleotidase signature 1. 862908001424 PS00237 G-protein coupled receptors signature. 862908001425 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 862908001426 HMMPfam hit to PF03553, Na+/H+ antiporter NhaC, score 6.3e-64 862908001427 10 probable transmembrane helices predicted for BMS0315 by TMHMM2.0 at aa 7-29, 39-61, 81-103, 113-135, 142-164, 197-219, 240-257, 262-281, 323-345 and 446-468 862908001428 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 862908001429 active site 862908001430 catalytic residues [active] 862908001431 HMMPfam hit to PF01263, Aldose 1-epimerase, score 8.3e-19 862908001432 1 probable transmembrane helix predicted for BMS0317 by TMHMM2.0 at aa 165-184 862908001433 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 862908001434 HMMPfam hit to PF03901, Alg9-like mannosyltransferase, score 1.4e-06 862908001435 9 probable transmembrane helices predicted for BMS0318 by TMHMM2.0 at aa 7-26, 82-104, 116-133, 170-192, 205-227, 255-277, 284-301, 306-325 and 332-354 862908001436 PS00190 Cytochrome c family heme-binding site signature. 862908001437 Signal peptide predicted for BMS0319 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.981 between residues 16 and 17 862908001438 Signal peptide predicted for BMS0320 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.973 between residues 21 and 22 862908001439 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908001440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908001441 non-specific DNA binding site [nucleotide binding]; other site 862908001442 salt bridge; other site 862908001443 sequence-specific DNA binding site [nucleotide binding]; other site 862908001444 HMMPfam hit to PF01381, Helix-turn-helix motif, score 3.6e-06 862908001445 Signal peptide predicted for BMS0322 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 20 and 21 862908001446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908001447 sequence-specific DNA binding site [nucleotide binding]; other site 862908001448 salt bridge; other site 862908001449 putative capsule biosynthesis cluster 862908001450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001451 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 862908001452 putative ADP-binding pocket [chemical binding]; other site 862908001453 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 3e-29 862908001454 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862908001455 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862908001456 NAD binding site [chemical binding]; other site 862908001457 homodimer interface [polypeptide binding]; other site 862908001458 active site 862908001459 substrate binding site [chemical binding]; other site 862908001460 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.6e-109 862908001461 O-Antigen ligase; Region: Wzy_C; pfam04932 862908001462 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 862908001463 Signal peptide predicted for BMS0329 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.527 between residues 27 and 28 862908001464 9 probable transmembrane helices predicted for BMS0329 by TMHMM2.0 at aa 13-35, 55-77, 90-107, 117-139, 160-182, 192-214, 231-253, 318-340 and 349-371 862908001465 HMMPfam hit to PF04932, O-antigen polymerase, score 2.8e-15 862908001466 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 862908001467 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 862908001468 NAD binding site [chemical binding]; other site 862908001469 substrate binding site [chemical binding]; other site 862908001470 homodimer interface [polypeptide binding]; other site 862908001471 active site 862908001472 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 6e-124 862908001473 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001474 Signal peptide predicted for BMS0330 by SignalP 2.0 HMM (Signal peptide probability 0.920) with cleavage site probability 0.594 between residues 23 and 24 862908001475 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 862908001476 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 862908001477 substrate binding site; other site 862908001478 tetramer interface; other site 862908001479 HMMPfam hit to PF00483, Nucleotidyl transferase, score 7.2e-98 862908001480 9 probable transmembrane helices predicted for BMS0332 by TMHMM2.0 at aa 7-29, 117-139, 159-181, 186-208, 229-246, 278-300, 305-327, 342-364 and 377-399 862908001481 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908001482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908001483 S-adenosylmethionine binding site [chemical binding]; other site 862908001484 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862908001485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908001486 S-adenosylmethionine binding site [chemical binding]; other site 862908001487 PS00307 Legume lectins beta-chain signature. 862908001488 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 862908001489 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 862908001490 Ligand binding site; other site 862908001491 Putative Catalytic site; other site 862908001492 DXD motif; other site 862908001493 2 probable transmembrane helices predicted for BMS0335 by TMHMM2.0 at aa 234-256 and 266-288 862908001494 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2e-32 862908001495 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862908001496 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 862908001497 PYR/PP interface [polypeptide binding]; other site 862908001498 dimer interface [polypeptide binding]; other site 862908001499 TPP binding site [chemical binding]; other site 862908001500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862908001501 HMMPfam hit to PF02780, Transketolase, C terminal, score 0.0013 862908001502 HMMPfam hit to PF02779, Transketolase, central region, score 6.1e-18 862908001503 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001504 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862908001505 TPP-binding site [chemical binding]; other site 862908001506 dimer interface [polypeptide binding]; other site 862908001507 HMMPfam hit to PF00456, Transketolase, N terminal, score 4.3e-14 862908001508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001509 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 862908001510 putative ADP-binding pocket [chemical binding]; other site 862908001511 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.7e-28 862908001512 Signal peptide predicted for BMS0342 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.462 between residues 42 and 43 862908001513 9 probable transmembrane helices predicted for BMS0342 by TMHMM2.0 at aa 21-43, 71-93, 106-123, 128-150, 229-251, 266-285, 306-328, 334-356 and 369-391 862908001514 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 862908001515 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 862908001516 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862908001517 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 862908001518 Signal peptide predicted for BMS0344 by SignalP 2.0 HMM (Signal peptide probability 0.707) with cleavage site probability 0.438 between residues 25 and 26 862908001519 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 6.1e-61 862908001520 1 probable transmembrane helix predicted for BMS0344 by TMHMM2.0 at aa 5-27 862908001521 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 4.5e-43 862908001522 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 3.5e-19 862908001523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908001524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908001525 NAD(P) binding site [chemical binding]; other site 862908001526 active site 862908001527 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.8e-77 862908001528 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 862908001529 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862908001530 active site 862908001531 dimer interface [polypeptide binding]; other site 862908001532 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862908001533 Ligand Binding Site [chemical binding]; other site 862908001534 Molecular Tunnel; other site 862908001535 PS00443 Glutamine amidotransferases class-II active site. 862908001536 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 3.7e-09 862908001537 HMMPfam hit to PF00733, Asparagine synthase, score 1.2e-68 862908001538 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908001539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001540 2 probable transmembrane helices predicted for BMS0347 by TMHMM2.0 at aa 51-73 and 80-102 862908001541 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 6.5e-18 862908001542 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 862908001543 6 probable transmembrane helices predicted for BMS0349 by TMHMM2.0 at aa 26-45, 50-72, 113-135, 140-157, 186-208 and 218-240 862908001544 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 862908001545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908001546 active site 862908001547 nucleotide binding site [chemical binding]; other site 862908001548 HIGH motif; other site 862908001549 KMSKS motif; other site 862908001550 HMMPfam hit to PF01467, Cytidylyltransferase, score 8.3e-15 862908001551 Signal peptide predicted for BMS0351 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.643 between residues 33 and 34 862908001552 2 probable transmembrane helices predicted for BMS0351 by TMHMM2.0 at aa 9-31 and 391-408 862908001553 12 probable transmembrane helices predicted for BMS0352 by TMHMM2.0 at aa 13-28, 33-50, 55-74, 89-111, 132-151, 183-200, 209-228, 233-250, 257-279, 379-401, 413-432 and 442-464 862908001554 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862908001555 10 probable transmembrane helices predicted for BMS0353 by TMHMM2.0 at aa 13-35, 42-64, 85-107, 141-160, 165-187, 245-267, 288-310, 330-352, 359-378 and 383-405 862908001556 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908001557 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 862908001558 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 862908001559 Mg++ binding site [ion binding]; other site 862908001560 putative catalytic motif [active] 862908001561 substrate binding site [chemical binding]; other site 862908001562 11 probable transmembrane helices predicted for BMS0355 by TMHMM2.0 at aa 4-26, 47-69, 74-91, 104-121, 134-156, 163-182, 187-204, 216-238, 248-270, 301-318 and 323-342 862908001563 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 2e-27 862908001564 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 862908001565 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 862908001566 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 862908001567 NAD(P) binding site [chemical binding]; other site 862908001568 homodimer interface [polypeptide binding]; other site 862908001569 substrate binding site [chemical binding]; other site 862908001570 active site 862908001571 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein CapD, score 3.4e-08 862908001572 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862908001573 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862908001574 inhibitor-cofactor binding pocket; inhibition site 862908001575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908001576 catalytic residue [active] 862908001577 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 4.3e-120 862908001578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862908001579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862908001580 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0012 862908001581 pseudaminic acid synthase; Region: PseI; TIGR03586 862908001582 NeuB family; Region: NeuB; pfam03102 862908001583 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 862908001584 NeuB binding interface [polypeptide binding]; other site 862908001585 putative substrate binding site [chemical binding]; other site 862908001586 HMMPfam hit to PF03102, NeuB, score 4e-111 862908001587 HMMPfam hit to PF01354, Antifreeze-like, score 4.1e-12 862908001588 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 862908001589 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 862908001590 putative active site [active] 862908001591 oxyanion strand; other site 862908001592 catalytic triad [active] 862908001593 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.5e-24 862908001594 HMMPfam hit to PF07685, , score 0.00068 862908001595 PS00442 Glutamine amidotransferases class-I active site. 862908001596 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 862908001597 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 862908001598 substrate binding site [chemical binding]; other site 862908001599 glutamase interaction surface [polypeptide binding]; other site 862908001600 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 1.3e-59 862908001601 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 862908001602 Ligand Binding Site [chemical binding]; other site 862908001603 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 862908001604 ligand binding site; other site 862908001605 tetramer interface; other site 862908001606 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 3.3e-16 862908001607 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 862908001608 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908001609 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 862908001610 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 862908001611 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862908001612 12 probable transmembrane helices predicted for BMS0367 by TMHMM2.0 at aa 12-31, 41-63, 84-106, 185-207, 228-250, 265-287, 314-336, 351-373, 380-399, 404-426, 439-461 and 471-493 862908001613 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908001614 Methyltransferase domain; Region: Methyltransf_11; pfam08241 862908001615 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908001616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908001617 NAD(P) binding site [chemical binding]; other site 862908001618 active site 862908001619 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.5e-25 862908001620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862908001621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001622 1 probable transmembrane helix predicted for BMS0370 by TMHMM2.0 at aa 90-112 862908001623 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1.7e-41 862908001624 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 862908001625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908001626 extended (e) SDRs; Region: SDR_e; cd08946 862908001627 NAD(P) binding site [chemical binding]; other site 862908001628 active site 862908001629 substrate binding site [chemical binding]; other site 862908001630 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862908001631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862908001632 active site 862908001633 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.1e-38 862908001634 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862908001635 9 probable transmembrane helices predicted for BMS0374 by TMHMM2.0 at aa 20-42, 57-76, 89-111, 115-137, 158-177, 181-200, 297-319, 334-356 and 369-391 862908001636 Signal peptide predicted for BMS0374 by SignalP 2.0 HMM (Signal peptide probability 0.898) with cleavage site probability 0.384 between residues 42 and 43 862908001637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908001639 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 4.9e-17 862908001640 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 862908001641 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 862908001642 Bacterial sugar transferase; Region: Bac_transf; pfam02397 862908001643 HMMPfam hit to PF02397, Bacterial sugar transferase, score 7.7e-41 862908001644 5 probable transmembrane helices predicted for BMS0376 by TMHMM2.0 at aa 11-33, 43-62, 83-101, 111-133 and 272-294 862908001645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908001646 active site 862908001647 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.5e-17 862908001648 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 862908001649 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862908001650 inhibitor-cofactor binding pocket; inhibition site 862908001651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908001652 catalytic residue [active] 862908001653 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.7e-130 862908001654 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 862908001655 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908001656 NAD binding site [chemical binding]; other site 862908001657 homotetramer interface [polypeptide binding]; other site 862908001658 homodimer interface [polypeptide binding]; other site 862908001659 active site 862908001660 substrate binding site [chemical binding]; other site 862908001661 Signal peptide predicted for BMS0380 by SignalP 2.0 HMM (Signal peptide probability 0.801) with cleavage site probability 0.469 between residues 18 and 19 862908001662 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.8e-40 862908001663 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862908001664 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 862908001665 substrate binding site; other site 862908001666 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3e-09 862908001667 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 862908001668 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 862908001669 NAD binding site [chemical binding]; other site 862908001670 homotetramer interface [polypeptide binding]; other site 862908001671 homodimer interface [polypeptide binding]; other site 862908001672 substrate binding site [chemical binding]; other site 862908001673 active site 862908001674 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908001675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908001676 NAD(P) binding site [chemical binding]; other site 862908001677 active site 862908001678 Predicted membrane protein [Function unknown]; Region: COG3463 862908001679 9 probable transmembrane helices predicted for BMS0384 by TMHMM2.0 at aa 9-31, 91-113, 120-142, 164-186, 199-221, 249-271, 278-297, 302-320 and 333-350 862908001680 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 862908001681 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 862908001682 HMMPfam hit to PF02366, Glycosyl transferase, family 39, score 4.2e-05 862908001683 9 probable transmembrane helices predicted for BMS0385 by TMHMM2.0 at aa 12-31, 85-107, 140-157, 170-192, 209-231, 261-283, 295-313, 318-340 and 347-369 862908001684 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908001685 Predicted integral membrane protein [Function unknown]; Region: COG5650 862908001686 13 probable transmembrane helices predicted for BMS0386 by TMHMM2.0 at aa 7-25, 35-52, 57-74, 89-111, 118-140, 181-203, 208-225, 254-273, 280-302, 312-334, 373-392, 397-416 and 423-440 862908001687 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 862908001688 HMMPfam hit to PF03901, Alg9-like mannosyltransferase, score 3e-06 862908001689 9 probable transmembrane helices predicted for BMS0387 by TMHMM2.0 at aa 13-35, 87-109, 130-149, 208-225, 232-254, 293-310, 315-332, 336-358 and 370-392 862908001690 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 862908001691 6 probable transmembrane helices predicted for BMS0388 by TMHMM2.0 at aa 35-52, 59-81, 120-137, 144-159, 164-181 and 194-212 862908001692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908001693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908001694 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.4e-15 862908001695 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 862908001696 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 862908001697 Ligand binding site; other site 862908001698 Ligand binding site; other site 862908001699 Ligand binding site; other site 862908001700 Putative Catalytic site; other site 862908001701 DXD motif; other site 862908001702 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 5.5e-13 862908001703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908001704 Methyltransferase domain; Region: Methyltransf_12; pfam08242 862908001705 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 862908001706 HMMPfam hit to PF03901, Alg9-like mannosyltransferase, score 3.3e-07 862908001707 9 probable transmembrane helices predicted for BMS0392 by TMHMM2.0 at aa 9-31, 88-110, 122-141, 146-163, 168-190, 210-232, 267-289, 317-336 and 349-371 862908001708 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 862908001709 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862908001710 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 862908001711 putative metal binding site; other site 862908001712 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 5.4e-20 862908001713 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862908001714 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862908001715 putative active site [active] 862908001716 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 862908001717 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 862908001718 putative ligand binding site [chemical binding]; other site 862908001719 putative NAD binding site [chemical binding]; other site 862908001720 catalytic site [active] 862908001721 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 5.8e-43 862908001722 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 862908001723 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 7.6e-09 862908001724 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 862908001725 active site 862908001726 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 862908001727 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 3.4e-32 862908001728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862908001729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862908001730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862908001731 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 3.6e-17 862908001732 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 0.033 862908001733 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862908001734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908001735 ATP binding site [chemical binding]; other site 862908001736 putative Mg++ binding site [ion binding]; other site 862908001737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908001738 nucleotide binding region [chemical binding]; other site 862908001739 ATP-binding site [chemical binding]; other site 862908001740 HMMPfam hit to PF00271, Helicase, C-terminal, score 1.4e-26 862908001741 HMMPfam hit to PF00176, SNF2-related, score 1.8e-53 862908001742 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.3e-06 862908001743 Signal peptide predicted for BMS0402 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.871 between residues 31 and 32 862908001744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908001746 active site 862908001747 phosphorylation site [posttranslational modification] 862908001748 intermolecular recognition site; other site 862908001749 dimerization interface [polypeptide binding]; other site 862908001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908001751 DNA binding site [nucleotide binding] 862908001752 HMMPfam hit to PF00072, Response regulator receiver, score 1.1e-06 862908001753 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 6.7e-13 862908001754 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 862908001755 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 862908001756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908001757 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862908001758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908001759 DNA binding residues [nucleotide binding] 862908001760 HMMPfam hit to PF04545, Sigma-70 region 4, score 3.1e-19 862908001761 PS00716 Sigma-70 factors family signature 2. 862908001762 HMMPfam hit to PF04539, Sigma-70 region 3, score 1.3e-43 862908001763 HMMPfam hit to PF04542, Sigma-70 region 2, score 1.8e-29 862908001764 PS00715 Sigma-70 factors family signature 1. 862908001765 HMMPfam hit to PF00140, Sigma-70 region 1.2, score 1.3e-13 862908001766 DNA primase; Validated; Region: dnaG; PRK05667 862908001767 CHC2 zinc finger; Region: zf-CHC2; cl17510 862908001768 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 862908001769 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 862908001770 active site 862908001771 metal binding site [ion binding]; metal-binding site 862908001772 interdomain interaction site; other site 862908001773 HMMPfam hit to PF01751, TOPRIM, score 3.1e-08 862908001774 HMMPfam hit to PF01807, Zn-finger, CHC2 type, score 4.9e-22 862908001775 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862908001776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908001777 S-adenosylmethionine binding site [chemical binding]; other site 862908001778 HMMPfam hit to PF02390, Putative methyltransferase, score 6.7e-44 862908001779 Signal peptide predicted for BMS0407 by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.936 between residues 42 and 43 862908001780 1 probable transmembrane helix predicted for BMS0408 by TMHMM2.0 at aa 13-30 862908001781 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908001782 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908001783 HMMPfam hit to PF01551, Peptidase M23B, score 2.8e-11 862908001784 Signal peptide predicted for BMS0409 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.813 between residues 22 and 23 862908001785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908001786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908001787 substrate binding pocket [chemical binding]; other site 862908001788 membrane-bound complex binding site; other site 862908001789 hinge residues; other site 862908001790 Signal peptide predicted for BMS0410 by SignalP 2.0 HMM (Signal peptide probability 0.783) with cleavage site probability 0.715 between residues 18 and 19 862908001791 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862908001792 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 862908001793 inhibitor-cofactor binding pocket; inhibition site 862908001794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908001795 catalytic residue [active] 862908001796 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.2e-87 862908001797 Signal peptide predicted for BMS0414 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.610 between residues 18 and 19 862908001798 Signal peptide predicted for BMS0415 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 19 and 20 862908001799 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 862908001800 nudix motif; other site 862908001801 HMMPfam hit to PF00293, NUDIX hydrolase, score 2.8e-18 862908001802 PS00893 mutT domain signature. 862908001803 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 862908001804 Peptidase family M50; Region: Peptidase_M50; pfam02163 862908001805 active site 862908001806 putative substrate binding region [chemical binding]; other site 862908001807 5 probable transmembrane helices predicted for BMS0417 by TMHMM2.0 at aa 7-29, 55-77, 98-120, 140-162 and 183-205 862908001808 HMMPfam hit to PF02163, Peptidase M50, score 1.3e-41 862908001809 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908001810 ScpA/B protein; Region: ScpA_ScpB; cl00598 862908001811 HMMPfam hit to PF02616, Protein of unknown function DUF173, score 4.3e-07 862908001812 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 862908001813 HMMPfam hit to PF04079, Conserved hypothetical protein 281, score 4.7e-55 862908001814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 862908001815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862908001816 RNA binding surface [nucleotide binding]; other site 862908001817 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 862908001818 active site 862908001819 HMMPfam hit to PF01479, RNA-binding S4, score 2.3e-09 862908001820 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.5e-18 862908001821 PS01149 Rsu family of pseudouridine synthase signature. 862908001822 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 862908001823 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862908001824 HMMPfam hit to PF02897, Peptidase S9A, prolyl oligopeptidase, N-terminal beta-propeller, score 1.8e-70 862908001825 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001826 HMMPfam hit to PF00326, Peptidase S9, prolyl oligopeptidase active site region, score 6.3e-79 862908001827 helicase 45; Provisional; Region: PTZ00424 862908001828 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862908001829 ATP binding site [chemical binding]; other site 862908001830 Mg++ binding site [ion binding]; other site 862908001831 motif III; other site 862908001832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908001833 nucleotide binding region [chemical binding]; other site 862908001834 ATP-binding site [chemical binding]; other site 862908001835 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 862908001836 RNA binding site [nucleotide binding]; other site 862908001837 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 1e-65 862908001838 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001839 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 862908001840 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.2e-36 862908001841 HI0933-like protein; Region: HI0933_like; pfam03486 862908001842 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908001843 Signal peptide predicted for BMS0425 by SignalP 2.0 HMM (Signal peptide probability 0.777) with cleavage site probability 0.638 between residues 25 and 26 862908001844 HMMPfam hit to PF03486, HI0933-like protein, score 7.4e-126 862908001845 Signal peptide predicted for BMS0426 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.985 between residues 18 and 19 862908001846 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 862908001847 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 862908001848 active site 862908001849 homodimer interface [polypeptide binding]; other site 862908001850 HMMPfam hit to PF03033, Glycosyl transferase, family 28, score 6.4e-30 862908001851 HMMPfam hit to PF04101, Glycosyltransferase 28, C-terminal, score 6e-28 862908001852 Signal peptide predicted for BMS0428 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.551 between residues 20 and 21 862908001853 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 862908001854 Signal peptide predicted for BMS0429 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 18 and 19 862908001855 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 862908001856 Signal peptide predicted for BMS0430 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 20 and 21 862908001857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908001858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908001859 active site 862908001860 phosphorylation site [posttranslational modification] 862908001861 intermolecular recognition site; other site 862908001862 dimerization interface [polypeptide binding]; other site 862908001863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908001864 DNA binding site [nucleotide binding] 862908001865 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.1e-14 862908001866 HMMPfam hit to PF00072, Response regulator receiver, score 1.6e-29 862908001867 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 862908001868 homodimer interface [polypeptide binding]; other site 862908001869 chemical substrate binding site [chemical binding]; other site 862908001870 oligomer interface [polypeptide binding]; other site 862908001871 metal binding site [ion binding]; metal-binding site 862908001872 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 862908001873 Signal peptide predicted for BMS0433 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.840 between residues 18 and 19 862908001874 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 862908001875 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 862908001876 G1 box; other site 862908001877 putative GEF interaction site [polypeptide binding]; other site 862908001878 GTP/Mg2+ binding site [chemical binding]; other site 862908001879 Switch I region; other site 862908001880 G2 box; other site 862908001881 G3 box; other site 862908001882 Switch II region; other site 862908001883 G4 box; other site 862908001884 G5 box; other site 862908001885 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 862908001886 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 862908001887 PS00107 Protein kinases ATP-binding region signature. 862908001888 HMMPfam hit to PF00679, Elongation factor G, C-terminal, score 2.6e-24 862908001889 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 1.2e-06 862908001890 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.5e-63 862908001891 PS00301 GTP-binding elongation factors signature. 862908001892 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001893 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862908001894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908001895 ABC transporter; Region: ABC_tran_2; pfam12848 862908001896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908001898 ABC transporter signature motif; other site 862908001899 Walker B; other site 862908001900 D-loop; other site 862908001901 H-loop/switch region; other site 862908001902 HMMPfam hit to PF00005, ABC transporter, score 2.4e-37 862908001903 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001904 HMMPfam hit to PF00005, ABC transporter, score 4.9e-32 862908001905 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001906 PS00211 ABC transporters family signature. 862908001907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862908001908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862908001909 DNA binding residues [nucleotide binding] 862908001910 dimerization interface [polypeptide binding]; other site 862908001911 Response regulator receiver domain; Region: Response_reg; pfam00072 862908001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908001913 active site 862908001914 phosphorylation site [posttranslational modification] 862908001915 intermolecular recognition site; other site 862908001916 dimerization interface [polypeptide binding]; other site 862908001917 PilZ domain; Region: PilZ; cl01260 862908001918 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 9.7e-11 862908001919 HMMPfam hit to PF00072, Response regulator receiver, score 3.8e-27 862908001920 mercuric reductase; Validated; Region: PRK06370 862908001921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908001922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862908001923 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.9e-29 862908001924 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 9.5e-81 862908001925 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 862908001926 3 probable transmembrane helices predicted for BMS0437 by TMHMM2.0 at aa 9-27, 42-64 and 85-104 862908001927 methionine sulfoxide reductase B; Provisional; Region: PRK00222 862908001928 SelR domain; Region: SelR; pfam01641 862908001929 HMMPfam hit to PF01641, Protein of unknown function DUF25, score 1.2e-70 862908001930 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 862908001931 5 probable transmembrane helices predicted for BMS0441 by TMHMM2.0 at aa 10-31, 57-79, 89-106, 127-149 and 154-172 862908001932 HMMPfam hit to PF03653, Conserved hypothetical protein 701, score 2.4e-35 862908001933 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862908001934 catalytic core [active] 862908001935 HMMPfam hit to PF00300, Phosphoglycerate/bisphosphoglycerate mutase, score 5.4e-23 862908001936 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 862908001937 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 862908001938 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 862908001939 active site 862908001940 metal-binding site [ion binding] 862908001941 nucleotide-binding site [chemical binding]; other site 862908001942 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase (ATP), score 7.9e-209 862908001943 PS00017 ATP/GTP-binding site motif A (P-loop). 862908001944 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862908001945 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 862908001946 motif 1; other site 862908001947 active site 862908001948 motif 2; other site 862908001949 motif 3; other site 862908001950 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 862908001951 DHHA1 domain; Region: DHHA1; pfam02272 862908001952 HMMPfam hit to PF01411, Alanyl-tRNA synthetase, class IIc, score 5.4e-273 862908001953 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908001954 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 6.4e-11 862908001955 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 862908001956 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 862908001957 dimer interface [polypeptide binding]; other site 862908001958 motif 1; other site 862908001959 active site 862908001960 motif 2; other site 862908001961 motif 3; other site 862908001962 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 862908001963 anticodon binding site; other site 862908001964 HMMPfam hit to PF00587, tRNA synthetases, class-II (G, H, P and S), score 1.6e-17 862908001965 HMMPfam hit to PF03129, Anticodon-binding, score 3.5e-06 862908001966 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908001967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862908001968 Signal peptide predicted for BMS0447 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.483 between residues 26 and 27 862908001969 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908001970 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 4.3e-24 862908001971 META domain; Region: META; pfam03724 862908001972 HMMPfam hit to PF03724, Protein of unknown function DUF306, score 5.7e-09 862908001973 Signal peptide predicted for BMS0448 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.606 between residues 24 and 25 862908001974 1 probable transmembrane helix predicted for BMS0449 by TMHMM2.0 at aa 15-32 862908001975 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862908001976 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.7e-05 862908001977 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.2 862908001978 methionine sulfoxide reductase A; Provisional; Region: PRK14054 862908001979 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 2.2e-84 862908001980 Outer membrane efflux protein; Region: OEP; pfam02321 862908001981 Outer membrane efflux protein; Region: OEP; pfam02321 862908001982 Signal peptide predicted for BMS0452 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.591 between residues 18 and 19 862908001983 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0021 862908001984 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.2e-10 862908001985 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908001986 Protein export membrane protein; Region: SecD_SecF; cl14618 862908001987 Protein export membrane protein; Region: SecD_SecF; cl14618 862908001988 HMMPfam hit to PF00873, Acriflavin resistance protein, score 4.2e-287 862908001989 10 probable transmembrane helices predicted for BMS0453 by TMHMM2.0 at aa 12-29, 337-356, 363-382, 392-414, 434-456, 529-546, 849-868, 878-897, 952-974 and 984-1006 862908001990 methionine sulfoxide reductase B; Provisional; Region: PRK00222 862908001991 SelR domain; Region: SelR; pfam01641 862908001992 HMMPfam hit to PF01641, Protein of unknown function DUF25, score 1.6e-78 862908001993 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908001994 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 3.3e-59 862908001995 3 probable transmembrane helices predicted for BMS0455 by TMHMM2.0 at aa 21-43, 68-90 and 95-117 862908001996 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 862908001997 Signal peptide predicted for BMS0456 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 17 and 18 862908001998 FOG: CBS domain [General function prediction only]; Region: COG0517 862908001999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 862908002000 HMMPfam hit to PF00571, CBS, score 8.8e-16 862908002001 HMMPfam hit to PF00571, CBS, score 1.9e-19 862908002002 CAAX protease self-immunity; Region: Abi; pfam02517 862908002003 HMMPfam hit to PF02517, Abortive infection protein, score 4e-08 862908002004 2 probable transmembrane helices predicted for BMS0460 by TMHMM2.0 at aa 7-24 and 39-61 862908002005 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 862908002006 Signal peptide predicted for BMS0461 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.939 between residues 16 and 17 862908002007 Signal peptide predicted for BMS0462 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.499 between residues 21 and 22 862908002008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908002009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908002010 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 862908002011 putative effector binding pocket; other site 862908002012 putative dimerization interface [polypeptide binding]; other site 862908002013 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.3e-33 862908002014 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.4e-19 862908002015 PS00044 Bacterial regulatory proteins, lysR family signature. 862908002016 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 862908002017 Signal peptide predicted for BMS0464 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.753 between residues 45 and 46 862908002018 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 862908002019 Signal peptide predicted for BMS0465 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.644 between residues 26 and 27 862908002020 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002021 Uncharacterized conserved protein [Function unknown]; Region: COG4925 862908002022 Signal peptide predicted for BMS0466 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 28 and 29 862908002023 1 probable transmembrane helix predicted for BMS0466 by TMHMM2.0 at aa 7-29 862908002024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862908002025 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 862908002026 putative NAD(P) binding site [chemical binding]; other site 862908002027 active site 862908002028 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 3.5e-57 862908002029 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 862908002030 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862908002031 DNA binding residues [nucleotide binding] 862908002032 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.4e-09 862908002033 PS00552 Bacterial regulatory proteins, merR family signature. 862908002034 Signal peptide predicted for BMS0470 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.920 between residues 18 and 19 862908002035 HMMPfam hit to PF00144, Beta-lactamase, score 9e-07 862908002036 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 862908002037 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 862908002038 active site 862908002039 Zn binding site [ion binding]; other site 862908002040 HMMPfam hit to PF01431, Peptidase M13, neprilysin, score 1.6e-55 862908002041 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908002042 HMMPfam hit to PF05649, Peptidase M13, score 2.1e-10 862908002043 PS00215 Mitochondrial energy transfer proteins signature. 862908002044 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 862908002045 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 862908002046 putative Iron-sulfur protein interface [polypeptide binding]; other site 862908002047 proximal heme binding site [chemical binding]; other site 862908002048 distal heme binding site [chemical binding]; other site 862908002049 putative dimer interface [polypeptide binding]; other site 862908002050 Signal peptide predicted for BMS0473 by SignalP 2.0 HMM (Signal peptide probability 0.813) with cleavage site probability 0.711 between residues 24 and 25 862908002051 5 probable transmembrane helices predicted for BMS0473 by TMHMM2.0 at aa 13-32, 52-74, 103-125, 156-175 and 195-217 862908002052 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 862908002053 L-aspartate oxidase; Provisional; Region: PRK06175 862908002054 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862908002055 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 2e-63 862908002056 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 2e-26 862908002057 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 862908002058 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 862908002059 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 862908002060 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.001 862908002061 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 862908002062 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 862908002063 transmembrane helices; other site 862908002064 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 2.6e-230 862908002065 12 probable transmembrane helices predicted for BMS0476 by TMHMM2.0 at aa 7-24, 44-66, 79-101, 111-130, 176-198, 218-240, 268-285, 290-312, 325-347, 357-379, 391-413 and 446-468 862908002066 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 862908002067 5 probable transmembrane helices predicted for BMS0477 by TMHMM2.0 at aa 28-50, 59-81, 121-143, 164-181 and 185-207 862908002068 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 0.0037 862908002069 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 862908002070 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 862908002071 8 probable transmembrane helices predicted for BMS0478 by TMHMM2.0 at aa 13-35, 55-77, 98-116, 121-143, 156-173, 188-207, 228-247 and 257-276 862908002072 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 1.9e-45 862908002073 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862908002074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862908002075 putative acyl-acceptor binding pocket; other site 862908002076 1 probable transmembrane helix predicted for BMS0479 by TMHMM2.0 at aa 5-27 862908002077 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.2e-06 862908002078 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 862908002079 4 probable transmembrane helices predicted for BMS0480 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 93-115 862908002080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908002081 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862908002082 NAD(P) binding site [chemical binding]; other site 862908002083 active site 862908002084 Signal peptide predicted for BMS0481 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.537 between residues 28 and 29 862908002085 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862908002086 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 862908002087 putative acyl-acceptor binding pocket; other site 862908002088 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.7e-14 862908002089 2 probable transmembrane helices predicted for BMS0484 by TMHMM2.0 at aa 5-27 and 47-69 862908002090 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 862908002091 G1 box; other site 862908002092 GTP/Mg2+ binding site [chemical binding]; other site 862908002093 Switch I region; other site 862908002094 G2 box; other site 862908002095 G3 box; other site 862908002096 Switch II region; other site 862908002097 G4 box; other site 862908002098 G5 box; other site 862908002099 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 7.8e-27 862908002100 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908002102 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862908002103 Walker A motif; other site 862908002104 ATP binding site [chemical binding]; other site 862908002105 Walker B motif; other site 862908002106 arginine finger; other site 862908002107 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 6.1e-68 862908002108 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 862908002109 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002110 2 probable transmembrane helices predicted for BMS0487 by TMHMM2.0 at aa 105-127 and 131-150 862908002111 Signal peptide predicted for BMS0488 by SignalP 2.0 HMM (Signal peptide probability 0.757) with cleavage site probability 0.616 between residues 24 and 25 862908002112 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 862908002113 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 862908002114 HMMPfam hit to PF03255, Acetyl-CoA carboxylase, alpha subunit, score 9.4e-81 862908002115 hypothetical protein; Provisional; Region: PRK11820 862908002116 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 862908002117 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 862908002118 HMMPfam hit to PF03755, Conserved hypothetical protein 255, score 4.9e-22 862908002119 PS00217 Sugar transport proteins signature 2. 862908002120 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 862908002121 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 862908002122 catalytic site [active] 862908002123 G-X2-G-X-G-K; other site 862908002124 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002125 PS00856 Guanylate kinase signature. 862908002126 HMMPfam hit to PF00625, Guanylate kinase, score 3e-30 862908002127 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 862908002128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908002129 Zn2+ binding site [ion binding]; other site 862908002130 Mg2+ binding site [ion binding]; other site 862908002131 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 862908002132 synthetase active site [active] 862908002133 NTP binding site [chemical binding]; other site 862908002134 metal binding site [ion binding]; metal-binding site 862908002135 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 862908002136 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 862908002137 PS00018 EF-hand calcium-binding domain. 862908002138 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 2.2e-12 862908002139 HMMPfam hit to PF04607, RelA/SpoT, score 1.3e-48 862908002140 HMMPfam hit to PF02824, TGS, score 3.9e-29 862908002141 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2.1e-09 862908002142 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908002143 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908002144 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908002145 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 862908002146 putative active site [active] 862908002147 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 3.5e-10 862908002148 1 probable transmembrane helix predicted for BMS0495 by TMHMM2.0 at aa 21-43 862908002149 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 862908002150 homotrimer interaction site [polypeptide binding]; other site 862908002151 putative active site [active] 862908002152 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 9.5e-49 862908002153 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 862908002154 Malic enzyme, N-terminal domain; Region: malic; pfam00390 862908002155 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 862908002156 putative NAD(P) binding site [chemical binding]; other site 862908002157 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 862908002158 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 9.4e-85 862908002159 HMMPfam hit to PF03949, Malic oxidoreductase, score 1.9e-126 862908002160 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002161 HMMPfam hit to PF00390, Malic oxidoreductase, score 3.3e-75 862908002162 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 862908002163 Na binding site [ion binding]; other site 862908002164 12 probable transmembrane helices predicted for BMS0498 by TMHMM2.0 at aa 15-37, 65-87, 92-114, 144-166, 176-195, 202-224, 234-256, 277-299, 326-348, 368-385, 395-414 and 452-469 862908002165 HMMPfam hit to PF00474, Na+/solute symporter, score 4e-07 862908002166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908002167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908002168 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862908002169 dimerization interface [polypeptide binding]; other site 862908002170 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.1e-15 862908002171 PS00044 Bacterial regulatory proteins, lysR family signature. 862908002172 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.9e-28 862908002173 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908002174 Signal peptide predicted for BMS0500 by SignalP 2.0 HMM (Signal peptide probability 0.687) with cleavage site probability 0.294 between residues 28 and 29 862908002175 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002176 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 862908002177 HMMPfam hit to PF04151, Peptidase, archaeal and bacterial C-terminal, score 1.1e-05 862908002178 HMMPfam hit to PF04151, Peptidase, archaeal and bacterial C-terminal, score 7e-13 862908002179 putative hydrolase; Provisional; Region: PRK10985 862908002180 PS01133 Uncharacterized protein family UPF0017 signature. 862908002181 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 862908002182 Mg++ binding site [ion binding]; other site 862908002183 11 probable transmembrane helices predicted for BMS0502 by TMHMM2.0 at aa 15-37, 57-79, 89-106, 118-137, 142-161, 168-187, 192-209, 216-238, 248-270, 306-325 and 330-347 862908002184 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862908002185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862908002186 Walker A/P-loop; other site 862908002187 ATP binding site [chemical binding]; other site 862908002188 Q-loop/lid; other site 862908002189 ABC transporter signature motif; other site 862908002190 Walker B; other site 862908002191 D-loop; other site 862908002192 H-loop/switch region; other site 862908002193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862908002194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862908002195 Walker A/P-loop; other site 862908002196 ATP binding site [chemical binding]; other site 862908002197 Q-loop/lid; other site 862908002198 ABC transporter signature motif; other site 862908002199 Walker B; other site 862908002200 D-loop; other site 862908002201 H-loop/switch region; other site 862908002202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862908002203 HMMPfam hit to PF00005, ABC transporter, score 2.2e-63 862908002204 PS00211 ABC transporters family signature. 862908002205 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002206 HMMPfam hit to PF00005, ABC transporter, score 5e-60 862908002207 PS00211 ABC transporters family signature. 862908002208 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908002210 active site 862908002211 phosphorylation site [posttranslational modification] 862908002212 intermolecular recognition site; other site 862908002213 HMMPfam hit to PF00072, Response regulator receiver, score 9.8e-09 862908002214 Signal peptide predicted for BMS0505 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.972 between residues 28 and 29 862908002215 Signal peptide predicted for BMS0506 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.764 between residues 24 and 25 862908002216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908002217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908002218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908002219 dimerization interface [polypeptide binding]; other site 862908002220 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.8e-21 862908002221 PS00044 Bacterial regulatory proteins, lysR family signature. 862908002222 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908002223 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 862908002224 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 862908002225 putative active site [active] 862908002226 Zn binding site [ion binding]; other site 862908002227 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 5.2e-44 862908002228 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862908002229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862908002230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908002231 dimer interface [polypeptide binding]; other site 862908002232 conserved gate region; other site 862908002233 putative PBP binding loops; other site 862908002234 ABC-ATPase subunit interface; other site 862908002235 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.4e-20 862908002236 Signal peptide predicted for BMS0511 by SignalP 2.0 HMM (Signal peptide probability 0.749) with cleavage site probability 0.366 between residues 26 and 27 862908002237 5 probable transmembrane helices predicted for BMS0511 by TMHMM2.0 at aa 10-32, 39-61, 76-98, 142-164 and 194-216 862908002238 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908002239 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 862908002240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908002241 Walker A/P-loop; other site 862908002242 ATP binding site [chemical binding]; other site 862908002243 Q-loop/lid; other site 862908002244 ABC transporter signature motif; other site 862908002245 Walker B; other site 862908002246 D-loop; other site 862908002247 H-loop/switch region; other site 862908002248 HMMPfam hit to PF00005, ABC transporter, score 9.5e-46 862908002249 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002250 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862908002251 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 862908002252 ligand binding site [chemical binding]; other site 862908002253 NAD binding site [chemical binding]; other site 862908002254 dimerization interface [polypeptide binding]; other site 862908002255 catalytic site [active] 862908002256 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 0.00018 862908002257 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.6e-60 862908002258 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 862908002259 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 862908002260 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 862908002261 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 862908002262 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 862908002263 GDP-binding site [chemical binding]; other site 862908002264 ACT binding site; other site 862908002265 IMP binding site; other site 862908002266 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 7.9e-177 862908002267 PS01266 Adenylosuccinate synthetase GTP-binding site. 862908002268 PS00513 Adenylosuccinate synthetase active site. 862908002269 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 862908002270 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862908002271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908002272 FeS/SAM binding site; other site 862908002273 HMMPfam hit to PF04055, Radical SAM, score 1.4e-28 862908002274 PS01278 Uncharacterized protein family UPF0004 signature. 862908002275 HMMPfam hit to PF00919, Protein of unknown function UPF0004, score 7e-34 862908002276 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 862908002277 6 probable transmembrane helices predicted for BMS0518 by TMHMM2.0 at aa 22-44, 54-71, 83-102, 112-134, 154-172 and 177-199 862908002278 HMMPfam hit to PF01545, Cation efflux protein, score 1.8e-06 862908002279 Fic family protein [Function unknown]; Region: COG3177 862908002280 Fic/DOC family; Region: Fic; pfam02661 862908002281 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 1e-16 862908002282 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002283 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 862908002284 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862908002285 6 probable transmembrane helices predicted for BMS0520 by TMHMM2.0 at aa 20-42, 115-137, 157-179, 192-214, 339-361 and 389-411 862908002286 HMMPfam hit to PF03929, PepSY-associated TM helix, score 15 862908002287 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.26 862908002288 HMMPfam hit to PF03929, PepSY-associated TM helix, score 0.0032 862908002289 HMMPfam hit to PF03929, PepSY-associated TM helix, score 4.4 862908002290 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 862908002291 Signal peptide predicted for BMS0521 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.793 between residues 18 and 19 862908002292 Signal peptide predicted for BMS0522 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.920 between residues 28 and 29 862908002293 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 862908002294 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862908002295 N-terminal plug; other site 862908002296 ligand-binding site [chemical binding]; other site 862908002297 HMMPfam hit to PF00593, TonB-dependent receptor, score 6.6e-20 862908002298 HMMPfam hit to PF07715, , score 1.2e-13 862908002299 Signal peptide predicted for BMS0523 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.530 between residues 26 and 27 862908002300 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 862908002301 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 862908002302 IucA / IucC family; Region: IucA_IucC; pfam04183 862908002303 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862908002304 HMMPfam hit to PF04183, IucA/IucC, score 1.2e-95 862908002305 PS01121 Caspase family histidine active site. 862908002306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 862908002307 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 862908002308 IucA / IucC family; Region: IucA_IucC; pfam04183 862908002309 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862908002310 HMMPfam hit to PF04183, IucA/IucC, score 7.9e-57 862908002311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908002312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862908002313 putative substrate translocation pore; other site 862908002314 10 probable transmembrane helices predicted for BMS0529 by TMHMM2.0 at aa 21-42, 52-74, 86-108, 178-200, 231-253, 268-290, 297-314, 324-346, 363-385 and 395-412 862908002315 HMMPfam hit to PF07690, , score 1.5e-29 862908002316 Signal peptide predicted for BMS0530 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 862908002317 8 probable transmembrane helices predicted for BMS0532 by TMHMM2.0 at aa 7-25, 40-59, 72-89, 99-121, 134-156, 166-184, 205-224 and 237-259 862908002318 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 862908002319 active site 862908002320 Zn binding site [ion binding]; other site 862908002321 HMMPfam hit to PF00383, Cytidine/deoxycytidylate deaminase, zinc-binding region, score 2.4e-19 862908002322 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 862908002323 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 862908002324 Signal peptide predicted for BMS0534 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.373 between residues 23 and 24 862908002325 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908002326 Signal peptide predicted for BMS0535 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.562 between residues 29 and 30 862908002327 1 probable transmembrane helix predicted for BMS0536 by TMHMM2.0 at aa 4-21 862908002328 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 862908002329 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 862908002330 HMMPfam hit to PF03023, Virulence factor MVIN-like, score 3.9e-100 862908002331 12 probable transmembrane helices predicted for BMS0537 by TMHMM2.0 at aa 89-111, 135-157, 164-186, 196-218, 256-278, 282-304, 317-339, 359-381, 393-412, 417-439, 451-473 and 488-510 862908002332 PS00041 Bacterial regulatory proteins, araC family signature. 862908002333 1 probable transmembrane helix predicted for BMS0539 by TMHMM2.0 at aa 7-26 862908002334 10 probable transmembrane helices predicted for BMS0540 by TMHMM2.0 at aa 12-34, 76-95, 171-193, 208-230, 237-259, 269-291, 298-320, 335-357, 364-386 and 401-423 862908002335 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 862908002336 active site 862908002337 substrate binding site [chemical binding]; other site 862908002338 cosubstrate binding site; other site 862908002339 catalytic site [active] 862908002340 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 6.8e-06 862908002341 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862908002342 peptide synthase; Provisional; Region: PRK09274 862908002343 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 862908002344 acyl-activating enzyme (AAE) consensus motif; other site 862908002345 putative AMP binding site [chemical binding]; other site 862908002346 putative active site [active] 862908002347 putative CoA binding site [chemical binding]; other site 862908002348 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1.2e-53 862908002349 PS00455 Putative AMP-binding domain signature. 862908002350 prenyltransferase; Provisional; Region: ubiA; PRK13592 862908002351 HMMPfam hit to PF01040, UbiA prenyltransferase, score 0.0033 862908002352 8 probable transmembrane helices predicted for BMS0543 by TMHMM2.0 at aa 31-48, 52-70, 114-136, 151-173, 185-202, 225-247, 254-273 and 283-300 862908002353 phosphoenolpyruvate synthase; Validated; Region: PRK06241 862908002354 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862908002355 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862908002356 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyruvate-binding, score 3.3e-37 862908002357 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 5.3e-28 862908002358 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 862908002359 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862908002360 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862908002361 GIY-YIG motif/motif A; other site 862908002362 active site 862908002363 catalytic site [active] 862908002364 putative DNA binding site [nucleotide binding]; other site 862908002365 metal binding site [ion binding]; metal-binding site 862908002366 UvrB/uvrC motif; Region: UVR; pfam02151 862908002367 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862908002368 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 9.9e-31 862908002369 HMMPfam hit to PF02151, UvrB/UvrC protein, score 0.0014 862908002370 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 862908002371 Stage II sporulation protein; Region: SpoIID; pfam08486 862908002372 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 862908002373 Signal peptide predicted for BMS0549 by SignalP 2.0 HMM (Signal peptide probability 0.829) with cleavage site probability 0.511 between residues 20 and 21 862908002374 Signal peptide predicted for BMS0550 by SignalP 2.0 HMM (Signal peptide probability 0.778) with cleavage site probability 0.331 between residues 23 and 24 862908002375 4 probable transmembrane helices predicted for BMS0552 by TMHMM2.0 at aa 32-51, 85-107, 180-202 and 235-257 862908002376 Thioredoxin; Region: Thioredoxin_4; pfam13462 862908002377 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862908002378 Signal peptide predicted for BMS0553 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.511 between residues 23 and 24 862908002379 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002380 HMMPfam hit to PF01323, DSBA oxidoreductase, score 5e-21 862908002381 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 862908002382 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862908002383 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 4.2e-21 862908002384 1 probable transmembrane helix predicted for BMS0555 by TMHMM2.0 at aa 28-50 862908002385 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 862908002386 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 862908002387 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 2.2e-67 862908002388 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 0.00016 862908002389 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862908002390 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 7.3e-34 862908002391 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 862908002392 Signal peptide predicted for BMS0558 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 862908002393 1 probable transmembrane helix predicted for BMS0558 by TMHMM2.0 at aa 215-237 862908002394 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 862908002395 Signal peptide predicted for BMS0559 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 26 and 27 862908002396 4 probable transmembrane helices predicted for BMS0559 by TMHMM2.0 at aa 54-76, 91-108, 194-216 and 231-248 862908002397 HMMPfam hit to PF00813, Type III secretion system inner membrane P protein, score 4.4e-105 862908002398 PS01060 Flagella transport protein fliP family signature 1. 862908002399 PS01061 Flagella transport protein fliP family signature 2. 862908002400 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 862908002401 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 4e-30 862908002402 2 probable transmembrane helices predicted for BMS0560 by TMHMM2.0 at aa 15-37 and 50-69 862908002403 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 862908002404 HMMPfam hit to PF01311, Type III secretion system inner membrane R protein, score 7.8e-13 862908002405 6 probable transmembrane helices predicted for BMS0561 by TMHMM2.0 at aa 10-32, 39-57, 72-94, 136-158, 186-208 and 215-237 862908002406 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 862908002407 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 862908002408 HMMPfam hit to PF01312, Type III secretion exporter, score 6.4e-117 862908002409 4 probable transmembrane helices predicted for BMS0562 by TMHMM2.0 at aa 35-57, 96-118, 145-167 and 192-214 862908002410 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 862908002411 FHIPEP family; Region: FHIPEP; pfam00771 862908002412 6 probable transmembrane helices predicted for BMS0563 by TMHMM2.0 at aa 18-40, 42-61, 116-138, 206-228, 248-267 and 288-310 862908002413 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 862908002414 PS00994 Bacterial export FHIPEP family signature. 862908002415 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 862908002416 HMMPfam hit to PF00448, GTP-binding signal recognition particle SRP54, G-domain, score 3.5e-05 862908002417 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 862908002418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862908002419 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 1.7e-14 862908002420 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002421 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908002422 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 862908002423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908002424 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862908002425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908002426 DNA binding residues [nucleotide binding] 862908002427 HMMPfam hit to PF04542, Sigma-70 region 2, score 2.6e-19 862908002428 PS00715 Sigma-70 factors family signature 1. 862908002429 HMMPfam hit to PF04539, Sigma-70 region 3, score 0.00012 862908002430 HMMPfam hit to PF04545, Sigma-70 region 4, score 2.1e-20 862908002431 PS00716 Sigma-70 factors family signature 2. 862908002432 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908002433 2 probable transmembrane helices predicted for BMS0568 by TMHMM2.0 at aa 10-32 and 266-288 862908002434 Signal peptide predicted for BMS0569 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.730 between residues 21 and 22 862908002435 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002436 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 862908002437 dephospho-CoA kinase; Region: TIGR00152 862908002438 CoA-binding site [chemical binding]; other site 862908002439 ATP-binding [chemical binding]; other site 862908002440 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 3.3e-40 862908002441 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002442 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 862908002443 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 862908002444 homodimer interface [polypeptide binding]; other site 862908002445 metal binding site [ion binding]; metal-binding site 862908002446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 862908002447 homodimer interface [polypeptide binding]; other site 862908002448 active site 862908002449 putative chemical substrate binding site [chemical binding]; other site 862908002450 metal binding site [ion binding]; metal-binding site 862908002451 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase, score 3.6e-06 862908002452 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase, score 2.2e-33 862908002453 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 862908002454 HMMPfam hit to PF02130, Protein of unknown function UPF0054, score 1.3e-27 862908002455 peptide chain release factor 2; Validated; Region: prfB; PRK00578 862908002456 This domain is found in peptide chain release factors; Region: PCRF; smart00937 862908002457 RF-1 domain; Region: RF-1; pfam00472 862908002458 HMMPfam hit to PF03462, PCRF, score 1.4e-41 862908002459 HMMPfam hit to PF00472, Class I peptide chain release factor, score 6.9e-66 862908002460 PS00745 Prokaryotic-type class I peptide chain release factors signature. 862908002461 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 862908002462 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862908002463 FtsX-like permease family; Region: FtsX; pfam02687 862908002464 4 probable transmembrane helices predicted for BMS0575 by TMHMM2.0 at aa 19-41, 266-288, 313-335 and 364-386 862908002465 HMMPfam hit to PF02687, Protein of unknown function DUF214, score 4.6e-06 862908002466 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862908002467 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862908002468 Walker A/P-loop; other site 862908002469 ATP binding site [chemical binding]; other site 862908002470 Q-loop/lid; other site 862908002471 ABC transporter signature motif; other site 862908002472 Walker B; other site 862908002473 D-loop; other site 862908002474 H-loop/switch region; other site 862908002475 HMMPfam hit to PF00005, ABC transporter, score 1.8e-46 862908002476 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002477 PS00211 ABC transporters family signature. 862908002478 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 862908002479 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908002480 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908002481 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908002482 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908002483 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862908002484 Surface antigen; Region: Bac_surface_Ag; pfam01103 862908002485 Signal peptide predicted for BMS0577 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.967 between residues 34 and 35 862908002486 1 probable transmembrane helix predicted for BMS0577 by TMHMM2.0 at aa 13-35 862908002487 HMMPfam hit to PF07244, Surface antigen variable number, score 0.62 862908002488 HMMPfam hit to PF07244, Surface antigen variable number, score 0.00052 862908002489 HMMPfam hit to PF07244, Surface antigen variable number, score 8e-05 862908002490 HMMPfam hit to PF07244, Surface antigen variable number, score 6.6e-06 862908002491 HMMPfam hit to PF07244, Surface antigen variable number, score 2.7e-05 862908002492 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 6.1e-52 862908002493 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 862908002494 Signal peptide predicted for BMS0578 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 26 and 27 862908002495 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 5.5e-10 862908002496 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 862908002497 trimer interface [polypeptide binding]; other site 862908002498 active site 862908002499 UDP-GlcNAc binding site [chemical binding]; other site 862908002500 lipid binding site [chemical binding]; lipid-binding site 862908002501 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.0078 862908002502 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.0021 862908002503 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.028 862908002504 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.98 862908002505 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.85 862908002506 PS00101 Hexapeptide-repeat containing-transferases signature. 862908002507 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.7 862908002508 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 862908002509 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.3e-11 862908002510 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 862908002511 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 862908002512 active site 862908002513 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.083 862908002514 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.016 862908002515 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 3 862908002516 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 27 862908002517 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9 862908002518 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.5 862908002519 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.4 862908002520 PS00101 Hexapeptide-repeat containing-transferases signature. 862908002521 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 65 862908002522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862908002523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862908002524 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862908002525 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.1e-25 862908002526 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 0.063 862908002527 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 862908002528 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 862908002529 HMMPfam hit to PF02684, Glycosyl transferase, family 19, score 3e-63 862908002530 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 862908002531 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 862908002532 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 8.1e-42 862908002533 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 862908002534 Signal peptide predicted for BMS0585 by SignalP 2.0 HMM (Signal peptide probability 0.920) with cleavage site probability 0.598 between residues 21 and 22 862908002535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908002536 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 862908002537 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 862908002538 RNA binding site [nucleotide binding]; other site 862908002539 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 862908002540 RNA binding site [nucleotide binding]; other site 862908002541 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 862908002542 RNA binding site [nucleotide binding]; other site 862908002543 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862908002544 RNA binding site [nucleotide binding]; other site 862908002545 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862908002546 RNA binding site [nucleotide binding]; other site 862908002547 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 862908002548 RNA binding site [nucleotide binding]; other site 862908002549 domain interface; other site 862908002550 HMMPfam hit to PF00575, RNA binding S1, score 4.8e-11 862908002551 HMMPfam hit to PF00575, RNA binding S1, score 1.7e-14 862908002552 HMMPfam hit to PF00575, RNA binding S1, score 3.9e-29 862908002553 HMMPfam hit to PF00575, RNA binding S1, score 3.2e-23 862908002554 HMMPfam hit to PF00575, RNA binding S1, score 1.1e-21 862908002555 HMMPfam hit to PF00575, RNA binding S1, score 2.8e-27 862908002556 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862908002557 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908002558 Signal peptide predicted for BMS0588 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 18 and 19 862908002559 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 0.00011 862908002560 PS00134 Serine proteases, trypsin family, histidine active site. 862908002561 PS00673 Serine proteases, V8 family, serine active site. 862908002562 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 862908002563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862908002564 tetrameric interface [polypeptide binding]; other site 862908002565 NAD binding site [chemical binding]; other site 862908002566 catalytic residues [active] 862908002567 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.1e-124 862908002568 hypothetical protein; Validated; Region: PRK07198 862908002569 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 862908002570 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 862908002571 dimerization interface [polypeptide binding]; other site 862908002572 active site 862908002573 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 7.1e-06 862908002574 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 862908002575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862908002576 active site 862908002577 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908002578 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 3.7e-06 862908002579 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 862908002580 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 862908002581 ATP-binding site [chemical binding]; other site 862908002582 Sugar specificity; other site 862908002583 Pyrimidine base specificity; other site 862908002584 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 1.7e-29 862908002585 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002586 PS00120 Lipases, serine active site. 862908002587 Signal peptide predicted for BMS0600 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.749 between residues 23 and 24 862908002588 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002589 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 862908002590 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 862908002591 HflX GTPase family; Region: HflX; cd01878 862908002592 G1 box; other site 862908002593 GTP/Mg2+ binding site [chemical binding]; other site 862908002594 Switch I region; other site 862908002595 G2 box; other site 862908002596 G3 box; other site 862908002597 Switch II region; other site 862908002598 G4 box; other site 862908002599 G5 box; other site 862908002600 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 9e-31 862908002601 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002602 pantoate--beta-alanine ligase; Region: panC; TIGR00018 862908002603 Pantoate-beta-alanine ligase; Region: PanC; cd00560 862908002604 active site 862908002605 ATP-binding site [chemical binding]; other site 862908002606 pantoate-binding site; other site 862908002607 HXXH motif; other site 862908002608 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 6.1e-105 862908002609 Flavoprotein; Region: Flavoprotein; pfam02441 862908002610 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 862908002611 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 862908002612 HMMPfam hit to PF04127, DNA/pantothenate metabolism flavoprotein, C-terminal, score 1.2e-09 862908002613 HMMPfam hit to PF02441, Flavoprotein, score 4.1e-29 862908002614 5 probable transmembrane helices predicted for BMS0605 by TMHMM2.0 at aa 10-29, 109-131, 135-157, 201-223 and 255-277 862908002615 hypothetical protein; Provisional; Region: PRK08317 862908002616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908002617 S-adenosylmethionine binding site [chemical binding]; other site 862908002618 Type III pantothenate kinase; Region: Pan_kinase; cl17198 862908002619 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 862908002620 oligomerization interface [polypeptide binding]; other site 862908002621 active site 862908002622 metal binding site [ion binding]; metal-binding site 862908002623 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 2.4e-110 862908002624 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 862908002625 ketol-acid reductoisomerase; Provisional; Region: PRK05479 862908002626 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 862908002627 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 862908002628 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 862908002629 homodimer interface [polypeptide binding]; other site 862908002630 substrate-cofactor binding pocket; other site 862908002631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908002632 catalytic residue [active] 862908002633 HMMPfam hit to PF01063, Aminotransferase, class IV, score 3.5e-08 862908002634 PS00770 Aminotransferases class-IV signature. 862908002635 Domain of unknown function (DUF329); Region: DUF329; pfam03884 862908002636 HMMPfam hit to PF03884, Protein of unknown function DUF329, score 1.8e-14 862908002637 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 862908002638 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 862908002639 active site 862908002640 dimerization interface [polypeptide binding]; other site 862908002641 HMMPfam hit to PF00459, Inositol monophosphatase, score 1.2e-49 862908002642 PS00629 Inositol monophosphatase family signature 1. 862908002643 CASP C terminal; Region: CASP_C; pfam08172 862908002644 1 probable transmembrane helix predicted for BMS0613 by TMHMM2.0 at aa 21-40 862908002645 HEAT repeats; Region: HEAT_2; pfam13646 862908002646 Signal peptide predicted for BMS0614 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.663 between residues 18 and 19 862908002647 Signal peptide predicted for BMS0615 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.509 between residues 37 and 38 862908002648 KpsF/GutQ family protein; Region: kpsF; TIGR00393 862908002649 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 862908002650 putative active site [active] 862908002651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 862908002652 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 9.7e-21 862908002653 HMMPfam hit to PF00571, CBS, score 4.4e-07 862908002654 HMMPfam hit to PF00571, CBS, score 9e-05 862908002655 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 862908002656 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862908002657 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 862908002658 putative active site [active] 862908002659 catalytic triad [active] 862908002660 putative dimer interface [polypeptide binding]; other site 862908002661 8 probable transmembrane helices predicted for BMS0617 by TMHMM2.0 at aa 5-27, 31-53, 66-83, 98-120, 133-155, 175-197, 204-226 and 514-533 862908002662 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 6.7e-06 862908002663 1 probable transmembrane helix predicted for BMS0618 by TMHMM2.0 at aa 190-212 862908002664 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 862908002665 catalytic triad [active] 862908002666 putative active site [active] 862908002667 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.7e-44 862908002668 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908002669 Signal peptide predicted for BMS0619 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.927 between residues 49 and 50 862908002670 1 probable transmembrane helix predicted for BMS0620 by TMHMM2.0 at aa 15-32 862908002671 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 862908002672 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 862908002673 6 probable transmembrane helices predicted for BMS0621 by TMHMM2.0 at aa 15-37, 42-64, 95-117, 129-148, 158-175 and 182-200 862908002674 HMMPfam hit to PF03006, Hly-III related proteins, score 1.2e-55 862908002675 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 862908002676 HMMPfam hit to PF01258, Zn-finger, prokaryotic DksA/TraR C4 type, score 7.1e-09 862908002677 HMMPfam hit to PF01613, Flavin reductase-like, score 1.6e-29 862908002678 YceG-like family; Region: YceG; pfam02618 862908002679 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 862908002680 dimerization interface [polypeptide binding]; other site 862908002681 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002682 HMMPfam hit to PF02618, Protein of unknown function DUF175, score 1.8e-118 862908002683 1 probable transmembrane helix predicted for BMS0624 by TMHMM2.0 at aa 20-42 862908002684 Signal peptide predicted for BMS0624 by SignalP 2.0 HMM (Signal peptide probability 0.818) with cleavage site probability 0.763 between residues 33 and 34 862908002685 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 862908002686 HMMPfam hit to PF03652, Conserved hypothetical protein 250, score 4.6e-21 862908002687 transcription termination factor Rho; Provisional; Region: rho; PRK09376 862908002688 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 862908002689 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 862908002690 RNA binding site [nucleotide binding]; other site 862908002691 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 862908002692 multimer interface [polypeptide binding]; other site 862908002693 Walker A motif; other site 862908002694 ATP binding site [chemical binding]; other site 862908002695 Walker B motif; other site 862908002696 HMMPfam hit to PF07498, Rho termination factor, N-terminal, score 2.3e-09 862908002697 HMMPfam hit to PF07497, Rho termination factor, RNA-binding, score 8.1e-57 862908002698 HMMPfam hit to PF00006, H+-transporting two-sector ATPase, alpha/beta subunit, central region, score 1.4e-63 862908002699 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002700 peptide chain release factor 1; Validated; Region: prfA; PRK00591 862908002701 This domain is found in peptide chain release factors; Region: PCRF; smart00937 862908002702 RF-1 domain; Region: RF-1; pfam00472 862908002703 HMMPfam hit to PF03462, PCRF, score 6e-55 862908002704 HMMPfam hit to PF00472, Class I peptide chain release factor, score 5.7e-66 862908002705 PS00745 Prokaryotic-type class I peptide chain release factors signature. 862908002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908002707 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 862908002708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908002709 S-adenosylmethionine binding site [chemical binding]; other site 862908002710 PS00092 N-6 Adenine-specific DNA methylases signature. 862908002711 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 862908002712 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 862908002713 hinge; other site 862908002714 active site 862908002715 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 6.2e-140 862908002716 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002717 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 862908002718 nucleotide binding site/active site [active] 862908002719 HIT family signature motif; other site 862908002720 catalytic residue [active] 862908002721 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 8.8e-30 862908002722 PS00892 HIT family signature. 862908002723 Signal peptide predicted for BMS0631 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.707 between residues 19 and 20 862908002724 Signal peptide predicted for BMS0633 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 18 and 19 862908002725 PS00888 Cyclic nucleotide-binding domain signature 1. 862908002726 Signal peptide predicted for BMS0634 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.440 between residues 22 and 23 862908002727 2 probable transmembrane helices predicted for BMS0635 by TMHMM2.0 at aa 7-24 and 87-104 862908002728 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 862908002729 HMMPfam hit to PF04443, Acyl-protein synthetase, LuxE, score 2.8e-39 862908002730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908002731 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 862908002732 NAD(P) binding site [chemical binding]; other site 862908002733 catalytic residues [active] 862908002734 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 862908002735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862908002736 acyl-activating enzyme (AAE) consensus motif; other site 862908002737 active site 862908002738 AMP binding site [chemical binding]; other site 862908002739 CoA binding site [chemical binding]; other site 862908002740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862908002741 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 862908002742 acyl-activating enzyme (AAE) consensus motif; other site 862908002743 AMP binding site [chemical binding]; other site 862908002744 active site 862908002745 CoA binding site [chemical binding]; other site 862908002746 PS00455 Putative AMP-binding domain signature. 862908002747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908002748 Zn2+ binding site [ion binding]; other site 862908002749 Mg2+ binding site [ion binding]; other site 862908002750 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 862908002751 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 862908002752 putative active site [active] 862908002753 putative dimer interface [polypeptide binding]; other site 862908002754 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.2e-14 862908002755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908002756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908002757 HMMPfam hit to PF00440, Bacterial regulatory protein, TetR, score 2.8e-18 862908002758 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908002759 Protein export membrane protein; Region: SecD_SecF; cl14618 862908002760 12 probable transmembrane helices predicted for BMS0643 by TMHMM2.0 at aa 7-29, 335-354, 361-383, 388-410, 431-453, 463-485, 526-545, 863-882, 889-911, 921-943, 970-992 and 1012-1034 862908002761 HMMPfam hit to PF00873, Acriflavin resistance protein, score 3e-107 862908002762 Signal peptide predicted for BMS0643 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.365 between residues 34 and 35 862908002763 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 862908002764 Signal peptide predicted for BMS0644 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 27 and 28 862908002765 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862908002766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908002767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908002768 HMMPfam hit to PF00005, ABC transporter, score 7.4e-36 862908002769 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002770 HMMPfam hit to PF00005, ABC transporter, score 2.3e-23 862908002771 PS00211 ABC transporters family signature. 862908002772 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002773 Flagellin N-methylase; Region: FliB; pfam03692 862908002774 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 2.1e-08 862908002775 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908002776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908002777 PS00190 Cytochrome c family heme-binding site signature. 862908002778 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908002779 ArsC family; Region: ArsC; pfam03960 862908002780 HMMPfam hit to PF03960, Arsenate reductase and related, score 1.4e-29 862908002781 DTW domain; Region: DTW; cl01221 862908002782 HMMPfam hit to PF03942, DTW, score 1.7e-35 862908002783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862908002784 FAD binding domain; Region: FAD_binding_4; pfam01565 862908002785 HMMPfam hit to PF02913, FAD linked oxidase, C-terminal, score 4.2e-07 862908002786 GTPase RsgA; Reviewed; Region: PRK00098 862908002787 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862908002788 RNA binding site [nucleotide binding]; other site 862908002789 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 862908002790 GTPase/Zn-binding domain interface [polypeptide binding]; other site 862908002791 GTP/Mg2+ binding site [chemical binding]; other site 862908002792 G4 box; other site 862908002793 G5 box; other site 862908002794 G1 box; other site 862908002795 Switch I region; other site 862908002796 G2 box; other site 862908002797 G3 box; other site 862908002798 Switch II region; other site 862908002799 HMMPfam hit to PF03193, Protein of unknown function DUF258, score 2.6e-63 862908002800 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002801 PilZ domain; Region: PilZ; pfam07238 862908002802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908002803 Signal peptide predicted for BMS0655 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.332 between residues 17 and 18 862908002804 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 862908002805 active site 862908002806 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin type, score 1.3e-62 862908002807 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 862908002808 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 862908002809 DHH family; Region: DHH; pfam01368 862908002810 DHHA1 domain; Region: DHHA1; pfam02272 862908002811 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 2e-12 862908002812 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 6e-40 862908002813 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908002814 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908002815 Signal peptide predicted for BMS0659 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.494 between residues 20 and 21 862908002816 Signal peptide predicted for BMS0660 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.528 between residues 21 and 22 862908002817 Signal peptide predicted for BMS0662 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.925 between residues 17 and 18 862908002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908002819 active site 862908002820 phosphorylation site [posttranslational modification] 862908002821 intermolecular recognition site; other site 862908002822 HMMPfam hit to PF00072, Response regulator receiver, score 1.6e-06 862908002823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908002824 S-adenosylmethionine binding site [chemical binding]; other site 862908002825 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908002826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908002827 active site 862908002828 phosphorylation site [posttranslational modification] 862908002829 intermolecular recognition site; other site 862908002830 dimerization interface [polypeptide binding]; other site 862908002831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908002832 binding surface 862908002833 TPR motif; other site 862908002834 HMMPfam hit to PF07719, , score 1; PF07719, Tetratricopeptide repeat 862908002835 HMMPfam hit to PF07719, , score 0.46; PF07719, Tetratricopeptide repeat 862908002836 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908002837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908002838 FeS/SAM binding site; other site 862908002839 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 862908002840 HMMPfam hit to PF04055, Radical SAM, score 4.9e-10 862908002841 2 probable transmembrane helices predicted for BMS0669 by TMHMM2.0 at aa 9-31 and 44-66 862908002842 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862908002843 active site 862908002844 catalytic site [active] 862908002845 substrate binding site [chemical binding]; other site 862908002846 HMMPfam hit to PF00929, Exonuclease, score 2.5e-34 862908002847 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 862908002848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908002849 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862908002850 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.4e-76 862908002851 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 862908002852 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 1e-37 862908002853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862908002854 E3 interaction surface; other site 862908002855 lipoyl attachment site [posttranslational modification]; other site 862908002856 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862908002857 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 862908002858 E3 interaction surface; other site 862908002859 lipoyl attachment site [posttranslational modification]; other site 862908002860 e3 binding domain; Region: E3_binding; pfam02817 862908002861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 862908002862 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 1.1e-28 862908002863 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 3.1e-24 862908002864 HMMPfam hit to PF02817, E3 binding, score 5e-08 862908002865 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 3.8e-98 862908002866 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 862908002867 putative trimer interface [polypeptide binding]; other site 862908002868 putative CoA binding site [chemical binding]; other site 862908002869 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.5 862908002870 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.4 862908002871 Signal peptide predicted for BMS0674 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.757 between residues 22 and 23 862908002872 3D domain; Region: 3D; pfam06725 862908002873 HMMPfam hit to PF06725, 3D, score 5.5e-11 862908002874 Signal peptide predicted for BMS0676 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.930 between residues 25 and 26 862908002875 Signal peptide predicted for BMS0677 by SignalP 2.0 HMM (Signal peptide probability 0.842) with cleavage site probability 0.274 between residues 32 and 33 862908002876 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908002877 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862908002878 Signal peptide predicted for BMS0679 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.728 between residues 30 and 31 862908002879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908002880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908002881 ATP binding site [chemical binding]; other site 862908002882 Mg2+ binding site [ion binding]; other site 862908002883 G-X-G motif; other site 862908002884 6 probable transmembrane helices predicted for BMS0680 by TMHMM2.0 at aa 21-43, 48-70, 83-100, 104-123, 130-147 and 162-180 862908002885 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.00014 862908002886 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 5.7e-10 862908002887 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 862908002888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908002889 active site 862908002890 phosphorylation site [posttranslational modification] 862908002891 intermolecular recognition site; other site 862908002892 dimerization interface [polypeptide binding]; other site 862908002893 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908002894 HMMPfam hit to PF00072, Response regulator receiver, score 7.7e-12 862908002895 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 3.5e-13 862908002896 Endonuclease I; Region: Endonuclease_1; pfam04231 862908002897 HMMPfam hit to PF04231, Endonuclease I, score 1.5e-15 862908002898 Signal peptide predicted for BMS0682 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.705 between residues 28 and 29 862908002899 Endonuclease I; Region: Endonuclease_1; pfam04231 862908002900 HMMPfam hit to PF04231, Endonuclease I, score 3.1e-22 862908002901 Signal peptide predicted for BMS0683 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.966 between residues 18 and 19 862908002902 Signal peptide predicted for BMS0684 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.801 between residues 23 and 24 862908002903 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908002904 putative catalytic site [active] 862908002905 putative metal binding site [ion binding]; other site 862908002906 putative phosphate binding site [ion binding]; other site 862908002907 Signal peptide predicted for BMS0685 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.904 between residues 23 and 24 862908002908 1 probable transmembrane helix predicted for BMS0685 by TMHMM2.0 at aa 9-31 862908002909 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.9e-06 862908002910 1 probable transmembrane helix predicted for BMS0686 by TMHMM2.0 at aa 13-35 862908002911 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002912 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 862908002913 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 862908002914 active site 862908002915 Zn binding site [ion binding]; other site 862908002916 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 4.2e-10 862908002917 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908002918 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 862908002919 Signal peptide predicted for BMS0688 by SignalP 2.0 HMM (Signal peptide probability 0.960) with cleavage site probability 0.948 between residues 17 and 18 862908002920 recombination factor protein RarA; Reviewed; Region: PRK13342 862908002921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908002922 Walker A motif; other site 862908002923 ATP binding site [chemical binding]; other site 862908002924 Walker B motif; other site 862908002925 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 862908002926 arginine finger; other site 862908002927 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 862908002928 HMMPfam hit to PF00004, AAA ATPase, central region, score 1.5e-11 862908002929 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 862908002930 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002931 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 862908002932 Signal peptide predicted for BMS0691 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.755 between residues 22 and 23 862908002933 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 862908002934 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 862908002935 HIGH motif; other site 862908002936 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 862908002937 active site 862908002938 KMSKS motif; other site 862908002939 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 862908002940 tRNA binding surface [nucleotide binding]; other site 862908002941 anticodon binding site; other site 862908002942 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 1.1e-253 862908002943 Signal peptide predicted for BMS0694 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.967 between residues 19 and 20 862908002944 PS00036 bZIP transcription factors basic domain signature. 862908002945 Maf-like protein; Region: Maf; pfam02545 862908002946 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 862908002947 active site 862908002948 dimer interface [polypeptide binding]; other site 862908002949 HMMPfam hit to PF02545, Maf-like protein, score 1.2e-48 862908002950 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 862908002951 HMMPfam hit to PF02594, Protein of unknown function DUF167, score 2.2e-14 862908002952 Signal peptide predicted for BMS0697 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.912 between residues 19 and 20 862908002953 Signal peptide predicted for BMS0699 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.446 between residues 27 and 28 862908002954 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908002955 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862908002956 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862908002957 Signal peptide predicted for BMS0700 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 21 and 22 862908002958 1 probable transmembrane helix predicted for BMS0700 by TMHMM2.0 at aa 7-29 862908002959 HMMPfam hit to PF03480, TRAP dicarboxylate transporter- DctP subunit, score 5.6e-10 862908002960 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002961 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 862908002962 4 probable transmembrane helices predicted for BMS0701 by TMHMM2.0 at aa 17-39, 49-71, 96-118 and 133-155 862908002963 DctM-like transporters; Region: DctM; pfam06808 862908002964 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 862908002965 Signal peptide predicted for BMS0702 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.391 between residues 43 and 44 862908002966 11 probable transmembrane helices predicted for BMS0702 by TMHMM2.0 at aa 9-31, 46-68, 77-99, 103-125, 137-159, 169-191, 212-234, 269-291, 311-345, 355-377 and 390-412 862908002967 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport system permease DctM subunit, score 8.4e-10 862908002968 Signal peptide predicted for BMS0703 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.801 between residues 20 and 21 862908002969 Signal peptide predicted for BMS0704 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.622 between residues 27 and 28 862908002970 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 862908002971 DHH family; Region: DHH; pfam01368 862908002972 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 2.3e-22 862908002973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862908002974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862908002975 Walker A/P-loop; other site 862908002976 ATP binding site [chemical binding]; other site 862908002977 Q-loop/lid; other site 862908002978 ABC transporter signature motif; other site 862908002979 Walker B; other site 862908002980 D-loop; other site 862908002981 H-loop/switch region; other site 862908002982 HMMPfam hit to PF00005, ABC transporter, score 3.3e-44 862908002983 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002984 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 862908002985 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 862908002986 6 probable transmembrane helices predicted for BMS0709 by TMHMM2.0 at aa 13-35, 55-77, 98-120, 135-157, 164-183 and 211-233 862908002987 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 862908002988 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862908002989 4 probable transmembrane helices predicted for BMS0710 by TMHMM2.0 at aa 5-27, 32-54, 67-89 and 476-498 862908002990 1 probable transmembrane helix predicted for BMS0711 by TMHMM2.0 at aa 5-22 862908002991 4 probable transmembrane helices predicted for BMS0712 by TMHMM2.0 at aa 56-78, 109-131, 161-183 and 196-218 862908002992 thymidine kinase; Provisional; Region: PRK04296 862908002993 AAA domain; Region: AAA_14; pfam13173 862908002994 HMMPfam hit to PF00265, Thymidine kinase, score 1.1e-65 862908002995 PS00017 ATP/GTP-binding site motif A (P-loop). 862908002996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862908002997 active site 862908002998 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 6.6e-28 862908002999 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 862908003000 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 862908003001 HMMPfam hit to PF00288, GHMP kinase, score 7.2e-14 862908003002 4 probable transmembrane helices predicted for BMS0717 by TMHMM2.0 at aa 12-34, 74-93, 106-123 and 127-149 862908003003 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 862908003004 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862908003005 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862908003006 Signal peptide predicted for BMS0718 by SignalP 2.0 HMM (Signal peptide probability 0.774) with cleavage site probability 0.678 between residues 22 and 23 862908003007 10 probable transmembrane helices predicted for BMS0718 by TMHMM2.0 at aa 5-22, 29-51, 71-93, 105-122, 126-145, 166-188, 203-225, 234-256, 266-285 and 292-309 862908003008 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 2.2e-29 862908003009 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 1.9e-24 862908003010 B12 binding domain; Region: B12-binding; pfam02310 862908003011 B12 binding site [chemical binding]; other site 862908003012 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862908003013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908003014 FeS/SAM binding site; other site 862908003015 HMMPfam hit to PF04055, Radical SAM, score 4.4e-20 862908003016 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 862908003017 catalytic residues [active] 862908003018 dimer interface [polypeptide binding]; other site 862908003019 HMMPfam hit to PF00255, Glutathione peroxidase, score 5.2e-62 862908003020 PS00763 Glutathione peroxidases signature 2. 862908003021 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 862908003022 SmpB-tmRNA interface; other site 862908003023 HMMPfam hit to PF01668, SmpB protein, score 2.7e-32 862908003024 PS01317 Protein smpB signature. 862908003025 Signal peptide predicted for BMS0722 by SignalP 2.0 HMM (Signal peptide probability 0.855) with cleavage site probability 0.849 between residues 44 and 45 862908003026 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 862908003027 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 862908003028 HMMPfam hit to PF00398, Ribosomal RNA adenine methylase transferase, score 2e-34 862908003029 UGMP family protein; Validated; Region: PRK09604 862908003030 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 862908003031 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 8.9e-19 862908003032 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908003033 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862908003034 Signal peptide predicted for BMS0725 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.827 between residues 29 and 30 862908003035 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908003036 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908003037 active site 862908003038 metal binding site [ion binding]; metal-binding site 862908003039 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 862908003040 PS00190 Cytochrome c family heme-binding site signature. 862908003041 PS00190 Cytochrome c family heme-binding site signature. 862908003042 PS00190 Cytochrome c family heme-binding site signature. 862908003043 PS00190 Cytochrome c family heme-binding site signature. 862908003044 Signal peptide predicted for BMS0726 by SignalP 2.0 HMM (Signal peptide probability 0.920) with cleavage site probability 0.761 between residues 24 and 25 862908003045 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 862908003046 Tetratricopeptide repeat; Region: TPR_6; pfam13174 862908003047 HMMPfam hit to PF07719, , score 0.031; PF07719, Tetratricopeptide repeat 862908003048 HMMPfam hit to PF07719, , score 0.53; PF07719, Tetratricopeptide repeat 862908003049 Signal peptide predicted for BMS0727 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.489 between residues 21 and 22 862908003050 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908003051 1 probable transmembrane helix predicted for BMS0728 by TMHMM2.0 at aa 5-22 862908003052 Signal peptide predicted for BMS0728 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.424 between residues 20 and 21 862908003053 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862908003054 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862908003055 ligand binding site [chemical binding]; other site 862908003056 HMMPfam hit to PF00691, OmpA/MotB, score 1.7e-32 862908003057 Signal peptide predicted for BMS0729 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.335 between residues 24 and 25 862908003058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908003059 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 862908003060 Signal peptide predicted for BMS0730 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.872 between residues 24 and 25 862908003061 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908003062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908003063 Response regulator receiver domain; Region: Response_reg; pfam00072 862908003064 active site 862908003065 phosphorylation site [posttranslational modification] 862908003066 intermolecular recognition site; other site 862908003067 dimerization interface [polypeptide binding]; other site 862908003068 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-23 862908003069 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 862908003070 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 862908003071 tetramer interface [polypeptide binding]; other site 862908003072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908003073 catalytic residue [active] 862908003074 HMMPfam hit to PF01212, Tryptophanase, score 1.4e-120 862908003075 Signal peptide predicted for BMS0733 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.960 between residues 18 and 19 862908003076 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 862908003077 Signal peptide predicted for BMS0735 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.815 between residues 19 and 20 862908003078 Signal peptide predicted for BMS0736 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.958 between residues 24 and 25 862908003079 Signal peptide predicted for BMS0737 by SignalP 2.0 HMM (Signal peptide probability 0.910) with cleavage site probability 0.410 between residues 26 and 27 862908003080 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908003081 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862908003082 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5e-10 862908003083 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862908003084 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862908003085 12 probable transmembrane helices predicted for BMS0739 by TMHMM2.0 at aa 35-57, 72-94, 115-137, 152-174, 187-209, 214-233, 260-282, 297-319, 340-362, 372-389, 409-431 and 435-457 862908003086 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.1e-33 862908003087 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 6.9e-33 862908003088 Trypsin; Region: Trypsin; pfam00089 862908003089 cleavage site 862908003090 active site 862908003091 substrate binding sites [chemical binding]; other site 862908003092 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908003093 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862908003094 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908003095 Signal peptide predicted for BMS0740 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.903 between residues 22 and 23 862908003096 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 7.2e-22 862908003097 PS00134 Serine proteases, trypsin family, histidine active site. 862908003098 PS00135 Serine proteases, trypsin family, serine active site. 862908003099 HMMPfam hit to PF00023, Ankyrin, score 0.0089 862908003100 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 862908003101 FAD binding pocket [chemical binding]; other site 862908003102 FAD binding motif [chemical binding]; other site 862908003103 phosphate binding motif [ion binding]; other site 862908003104 NAD binding pocket [chemical binding]; other site 862908003105 HMMPfam hit to PF04954, Siderophore-interacting protein, score 9e-07 862908003106 Signal peptide predicted for BMS0742 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.965 between residues 25 and 26 862908003107 Signal peptide predicted for BMS0743 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.873 between residues 19 and 20 862908003108 PS00687 Aldehyde dehydrogenases glutamic acid active site. 862908003109 Signal peptide predicted for BMS0744 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.984 between residues 24 and 25 862908003110 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 862908003111 3 probable transmembrane helices predicted for BMS0745 by TMHMM2.0 at aa 7-26, 73-95 and 102-119 862908003112 HMMPfam hit to PF06993, Protein of unknown function DUF1304, score 1.2e-50 862908003113 Signal peptide predicted for BMS0746 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 18 and 19 862908003114 3 probable transmembrane helices predicted for BMS0747 by TMHMM2.0 at aa 5-24, 28-45 and 58-91 862908003115 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908003116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908003117 non-specific DNA binding site [nucleotide binding]; other site 862908003118 salt bridge; other site 862908003119 sequence-specific DNA binding site [nucleotide binding]; other site 862908003120 HMMPfam hit to PF01381, Helix-turn-helix motif, score 2.9e-14 862908003121 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 862908003122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862908003123 active site 862908003124 Int/Topo IB signature motif; other site 862908003125 DNA binding site [nucleotide binding] 862908003126 HMMPfam hit to PF00589, Phage integrase, score 4e-19 862908003128 HMMPfam hit to PF00589, Phage integrase, score 0.021 862908003129 Helix-turn-helix domain; Region: HTH_17; pfam12728 862908003130 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00092 N-6 Adenine-specific DNA methylases signature. 862908003131 1 probable transmembrane helix predicted for BMS0753 by TMHMM2.0 at aa 20-42 862908003132 Helix-turn-helix domain; Region: HTH_36; pfam13730 862908003133 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 862908003134 Signal peptide predicted for BMS0757 by SignalP 2.0 HMM (Signal peptide probability 0.759) with cleavage site probability 0.276 between residues 20 and 21 862908003135 3 probable transmembrane helices predicted for BMS0758 by TMHMM2.0 at aa 20-42, 57-79 and 91-113 862908003136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908003137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908003138 non-specific DNA binding site [nucleotide binding]; other site 862908003139 salt bridge; other site 862908003140 sequence-specific DNA binding site [nucleotide binding]; other site 862908003141 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862908003142 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862908003143 catalytic residues [active] 862908003144 catalytic nucleophile [active] 862908003145 HMMPfam hit to PF00239, Resolvase, N-terminal, score 2.9e-25 862908003146 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 862908003147 HMMPfam hit to PF01402, Helix-turn-helix protein, CopG, score 6.3e-05 862908003148 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 862908003149 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908003150 HNH endonuclease; Region: HNH_5; pfam14279 862908003151 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 862908003152 integrase; Provisional; Region: int; PHA02601 862908003153 Phage integrase family; Region: Phage_integrase; pfam00589 862908003154 active site 862908003155 DNA binding site [nucleotide binding] 862908003156 Int/Topo IB signature motif; other site 862908003157 HMMPfam hit to PF00589, Phage integrase, score 2.5e-32 862908003158 Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066 862908003159 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003160 Helix-turn-helix domain; Region: HTH_36; pfam13730 862908003161 Helix-turn-helix domain; Region: HTH_17; pfam12728 862908003162 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 862908003163 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 862908003164 putative active site [active] 862908003165 putative NTP binding site [chemical binding]; other site 862908003166 putative nucleic acid binding site [nucleotide binding]; other site 862908003167 HMMPfam hit to PF00078, RNA-directed DNA polymerase (Reverse transcriptase), score 1.8e-16 862908003168 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 862908003169 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 862908003170 putative active site [active] 862908003171 putative metal-binding site [ion binding]; other site 862908003172 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003173 1 probable transmembrane helix predicted for BMS0783 by TMHMM2.0 at aa 4-26 862908003174 3 probable transmembrane helices predicted for BMS0788 by TMHMM2.0 at aa 46-65, 87-109 and 116-138 862908003175 DNA binding domain, excisionase family; Region: excise; TIGR01764 862908003176 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 0.00027 862908003177 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 862908003178 HsdM N-terminal domain; Region: HsdM_N; pfam12161 862908003179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908003180 S-adenosylmethionine binding site [chemical binding]; other site 862908003181 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 862908003182 HMMPfam hit to PF02506, Type I restriction-modification system, M subunit, score 8.5e-66 862908003183 PS00092 N-6 Adenine-specific DNA methylases signature. 862908003184 HMMPfam hit to PF02384, N-6 DNA methylase, score 1.5e-68 862908003185 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 862908003186 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 862908003187 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 862908003188 HMMPfam hit to PF01420, Restriction modification system DNA specificity domain, score 9.3e-31 862908003189 HMMPfam hit to PF01420, Restriction modification system DNA specificity domain, score 5.5e-13 862908003190 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 862908003191 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 862908003192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908003193 ATP binding site [chemical binding]; other site 862908003194 putative Mg++ binding site [ion binding]; other site 862908003195 HMMPfam hit to PF04313, Protein of unknown function DUF450, score 1.8e-26 862908003196 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 4.5e-19 862908003197 Protein of unknown function DUF45; Region: DUF45; pfam01863 862908003198 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 3e-25 862908003199 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908003200 3 probable transmembrane helices predicted for BMS0794 by TMHMM2.0 at aa 17-36, 46-68 and 131-153 862908003201 Divergent AAA domain; Region: AAA_4; pfam04326 862908003202 HMMPfam hit to PF04326, Protein of unknown function DUF467, score 4e-08 862908003203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862908003204 Divergent AAA domain; Region: AAA_4; pfam04326 862908003205 HMMPfam hit to PF04326, Protein of unknown function DUF467, score 2.5e-11 862908003206 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 862908003207 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 862908003208 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 862908003209 active site 862908003210 zinc binding site [ion binding]; other site 862908003211 HMMPfam hit to PF05147, Lanthionine synthetase C-like, score 2.8e-11 862908003212 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 862908003213 Cupin domain; Region: Cupin_2; pfam07883 862908003214 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 862908003215 HMMPfam hit to PF00190, Cupin, score 0.0037 862908003216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908003217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908003218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862908003219 dimerization interface [polypeptide binding]; other site 862908003220 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.9e-11 862908003221 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.2e-09 862908003222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862908003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862908003224 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 8.4e-06 862908003225 Signal peptide predicted for BMS0811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 18 and 19 862908003226 Signal peptide predicted for BMS0813 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 19 and 20 862908003227 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862908003228 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 862908003229 1 probable transmembrane helix predicted for BMS0816 by TMHMM2.0 at aa 5-27 862908003230 Signal peptide predicted for BMS0816 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.672 between residues 24 and 25 862908003231 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908003232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908003233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908003234 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862908003235 HMMPfam hit to PF00440, Bacterial regulatory protein, TetR, score 1.6e-18 862908003236 PS01081 Bacterial regulatory proteins, tetR family signature. 862908003237 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 862908003238 4 probable transmembrane helices predicted for BMS0818 by TMHMM2.0 at aa 5-27, 42-61, 66-88 and 93-115 862908003239 HMMPfam hit to PF00893, Small multidrug resistance protein, score 4.1e-45 862908003240 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862908003241 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 862908003242 intersubunit interface [polypeptide binding]; other site 862908003243 Signal peptide predicted for BMS0819 by SignalP 2.0 HMM (Signal peptide probability 0.794) with cleavage site probability 0.661 between residues 31 and 32 862908003244 HMMPfam hit to PF01497, Periplasmic binding protein, score 8.8e-22 862908003245 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 862908003246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862908003247 ABC-ATPase subunit interface; other site 862908003248 dimer interface [polypeptide binding]; other site 862908003249 putative PBP binding regions; other site 862908003250 9 probable transmembrane helices predicted for BMS0820 by TMHMM2.0 at aa 23-45, 71-93, 100-122, 132-153, 166-188, 208-230, 259-281, 291-313 and 320-342 862908003251 HMMPfam hit to PF01032, Bacterial transport system permease protein, score 4.3e-79 862908003252 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 862908003253 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862908003254 Walker A/P-loop; other site 862908003255 ATP binding site [chemical binding]; other site 862908003256 Q-loop/lid; other site 862908003257 ABC transporter signature motif; other site 862908003258 Walker B; other site 862908003259 D-loop; other site 862908003260 H-loop/switch region; other site 862908003261 HMMPfam hit to PF00005, ABC transporter, score 2.1e-40 862908003262 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003263 PS00211 ABC transporters family signature. 862908003264 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 862908003265 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862908003266 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 862908003267 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, score 0.0007 862908003268 fumarate hydratase; Reviewed; Region: fumC; PRK00485 862908003269 Class II fumarases; Region: Fumarase_classII; cd01362 862908003270 active site 862908003271 tetramer interface [polypeptide binding]; other site 862908003272 HMMPfam hit to PF00206, Fumarate lyase, score 2.2e-158 862908003273 PS00163 Fumarate lyases signature. 862908003274 Signal peptide predicted for BMS0825 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.871 between residues 20 and 21 862908003275 Signal peptide predicted for BMS0826 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.435 between residues 25 and 26 862908003276 Signal peptide predicted for BMS0827 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.985 between residues 26 and 27 862908003277 Signal peptide predicted for BMS0828 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.833 between residues 18 and 19 862908003278 Signal peptide predicted for BMS0829 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.592 between residues 22 and 23 862908003279 Signal peptide predicted for BMS0832 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 862908003280 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862908003281 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 862908003282 active site 862908003283 Zn binding site [ion binding]; other site 862908003284 HMMPfam hit to PF00850, Histone deacetylase superfamily, score 3.8e-65 862908003285 Endonuclease I; Region: Endonuclease_1; pfam04231 862908003286 Signal peptide predicted for BMS0834 by SignalP 2.0 HMM (Signal peptide probability 0.889) with cleavage site probability 0.547 between residues 20 and 21 862908003287 HMMPfam hit to PF04231, Endonuclease I, score 1.6e-21 862908003288 PS00697 ATP-dependent DNA ligase AMP-binding site. 862908003289 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 862908003290 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 862908003291 oligomer interface [polypeptide binding]; other site 862908003292 metal binding site [ion binding]; metal-binding site 862908003293 metal binding site [ion binding]; metal-binding site 862908003294 Cl binding site [ion binding]; other site 862908003295 aspartate ring; other site 862908003296 basic sphincter; other site 862908003297 putative hydrophobic gate; other site 862908003298 periplasmic entrance; other site 862908003299 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 2.8e-60 862908003300 2 probable transmembrane helices predicted for BMS0835 by TMHMM2.0 at aa 298-320 and 330-349 862908003301 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 862908003302 Carbon starvation protein CstA; Region: CstA; pfam02554 862908003303 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 862908003304 12 probable transmembrane helices predicted for BMS0836 by TMHMM2.0 at aa 2-19, 64-86, 128-150, 165-183, 190-212, 239-261, 282-304, 328-350, 378-400, 404-423, 430-452 and 462-479 862908003305 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 5.8e-29 862908003306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908003307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908003308 catalytic residue [active] 862908003309 putative S-transferase; Provisional; Region: PRK11752 862908003310 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 862908003311 C-terminal domain interface [polypeptide binding]; other site 862908003312 GSH binding site (G-site) [chemical binding]; other site 862908003313 dimer interface [polypeptide binding]; other site 862908003314 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 862908003315 dimer interface [polypeptide binding]; other site 862908003316 N-terminal domain interface [polypeptide binding]; other site 862908003317 active site 862908003318 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 9.4e-05 862908003319 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 862908003320 4 probable transmembrane helices predicted for BMS0839 by TMHMM2.0 at aa 5-24, 34-51, 63-82 and 86-108 862908003321 HMMPfam hit to PF00893, Small multidrug resistance protein, score 6.3e-31 862908003322 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 862908003323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908003324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862908003325 dimerization interface [polypeptide binding]; other site 862908003326 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.9e-11 862908003327 PS00044 Bacterial regulatory proteins, lysR family signature. 862908003328 LysE type translocator; Region: LysE; cl00565 862908003329 5 probable transmembrane helices predicted for BMS0841 by TMHMM2.0 at aa 4-26, 38-60, 64-86, 110-132 and 147-169 862908003330 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 3.8e-31 862908003331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 862908003332 Cytochrome P450; Region: p450; cl12078 862908003333 HMMPfam hit to PF00067, Cytochrome P450, score 4.5e-38 862908003334 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 862908003335 ZIP Zinc transporter; Region: Zip; pfam02535 862908003336 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 862908003337 HMMPfam hit to PF02535, Zinc transporter ZIP, score 1.1e-24 862908003338 8 probable transmembrane helices predicted for BMS0843 by TMHMM2.0 at aa 4-26, 39-58, 73-95, 115-137, 147-169, 176-198, 208-230 and 237-255 862908003339 2 probable transmembrane helices predicted for BMS0845 by TMHMM2.0 at aa 4-21 and 77-99 862908003340 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862908003341 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862908003342 putative acyl-acceptor binding pocket; other site 862908003343 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 2.4e-18 862908003344 1 probable transmembrane helix predicted for BMS0846 by TMHMM2.0 at aa 7-29 862908003345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 862908003346 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 862908003347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 862908003348 metal binding site [ion binding]; metal-binding site 862908003349 HMMPfam hit to PF01546, Peptidase M20, score 4e-17 862908003350 HMMPfam hit to PF07687, , score 2.5e-10 862908003351 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 862908003352 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 862908003353 Signal peptide predicted for BMS0851 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.612 between residues 31 and 32 862908003354 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 862908003355 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 862908003356 PhnA protein; Region: PhnA; pfam03831 862908003357 HMMPfam hit to PF03831, PhnA protein, score 4.8e-26 862908003358 Uncharacterized conserved protein [Function unknown]; Region: COG4095 862908003359 3 probable transmembrane helices predicted for BMS0854 by TMHMM2.0 at aa 4-26, 38-60 and 65-84 862908003360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908003361 spermidine synthase; Provisional; Region: PRK00811 862908003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908003363 S-adenosylmethionine binding site [chemical binding]; other site 862908003364 HMMPfam hit to PF01564, Spermine synthase, score 4.2e-82 862908003365 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 862908003366 catalytic residues [active] 862908003367 dimer interface [polypeptide binding]; other site 862908003368 HMMPfam hit to PF00255, Glutathione peroxidase, score 3e-23 862908003369 Signal peptide predicted for BMS0857 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.780 between residues 18 and 19 862908003370 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862908003371 GAF domain; Region: GAF; pfam01590 862908003372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908003373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908003374 dimer interface [polypeptide binding]; other site 862908003375 phosphorylation site [posttranslational modification] 862908003376 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 862908003377 HMMPfam hit to PF01590, GAF, score 2.9e-08 862908003378 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.9e-06 862908003379 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.026 862908003380 1 probable transmembrane helix predicted for BMS0859 by TMHMM2.0 at aa 5-27 862908003381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908003382 motif II; other site 862908003383 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.1e-22 862908003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908003385 2 probable transmembrane helices predicted for BMS0862 by TMHMM2.0 at aa 13-32 and 42-64 862908003386 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 862908003387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908003388 FeS/SAM binding site; other site 862908003389 HMMPfam hit to PF04055, Radical SAM, score 1.8e-08 862908003390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908003391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908003392 HMMPfam hit to PF00440, Bacterial regulatory protein, TetR, score 1e-07 862908003393 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 862908003394 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 862908003395 4 probable transmembrane helices predicted for BMS0866 by TMHMM2.0 at aa 17-39, 75-97, 104-126 and 146-163 862908003396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862908003397 catalytic residues [active] 862908003398 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 862908003399 putative catalytic residues [active] 862908003400 Signal peptide predicted for BMS0867 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.865 between residues 20 and 21 862908003401 PS00194 Thioredoxin family active site. 862908003402 Protein of unknown function (DUF968); Region: DUF968; pfam06147 862908003403 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 862908003404 hydrophobic ligand binding site; other site 862908003405 Signal peptide predicted for BMS0869 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 18 and 19 862908003406 4 probable transmembrane helices predicted for BMS0870 by TMHMM2.0 at aa 13-35, 48-70, 109-128 and 138-160 862908003407 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 862908003408 HMMPfam hit to PF07308, Protein of unknown function DUF1456, score 1.2e-35 862908003409 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 862908003410 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 862908003411 active site 862908003412 Signal peptide predicted for BMS0873 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.794 between residues 23 and 24 862908003413 HMMPfam hit to PF01183, Glycoside hydrolase, family 25, score 3e-07 862908003414 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 862908003415 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 3.8e-05 862908003416 Fibrillar collagen C-terminal domain; Region: COLFI; cl02436 862908003417 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 862908003418 1 probable transmembrane helix predicted for BMS0878 by TMHMM2.0 at aa 4-26 862908003419 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 862908003420 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862908003421 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908003422 HMMPfam hit to PF00023, Ankyrin, score 4.5e-06 862908003423 HMMPfam hit to PF00023, Ankyrin, score 0.076 862908003424 HMMPfam hit to PF00023, Ankyrin, score 1.7e-07 862908003425 Signal peptide predicted for BMS0879 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.957 between residues 20 and 21 862908003426 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 862908003427 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 862908003428 tetramer interface [polypeptide binding]; other site 862908003429 heme binding pocket [chemical binding]; other site 862908003430 HMMPfam hit to PF00199, Catalase, score 4.2e-215 862908003431 PS00437 Catalase proximal heme-ligand signature. 862908003432 PS00438 Catalase proximal active site signature. 862908003433 Signal peptide predicted for BMS0880 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 862908003434 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862908003435 8 probable transmembrane helices predicted for BMS0881 by TMHMM2.0 at aa 7-29, 44-66, 79-98, 103-125, 138-160, 175-197, 209-231 and 246-261 862908003436 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 1.5e-35 862908003437 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 862908003438 2 probable transmembrane helices predicted for BMS0883 by TMHMM2.0 at aa 12-34 and 44-63 862908003439 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 862908003440 Signal peptide predicted for BMS0884 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.946 between residues 18 and 19 862908003441 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 3.6e-11 862908003442 PS00190 Cytochrome c family heme-binding site signature. 862908003443 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003444 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862908003445 PS00120 Lipases, serine active site. 862908003446 Signal peptide predicted for BMS0885 by SignalP 2.0 HMM (Signal peptide probability 0.759) with cleavage site probability 0.206 between residues 31 and 32 862908003447 3 probable transmembrane helices predicted for BMS0886 by TMHMM2.0 at aa 5-24, 39-61 and 211-230 862908003448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908003449 FeS/SAM binding site; other site 862908003450 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908003451 HMMPfam hit to PF04055, Radical SAM, score 7.4e-12 862908003452 PS01305 moaA / nifB / pqqE family signature. 862908003453 Predicted transporter component [General function prediction only]; Region: COG2391 862908003454 Sulphur transport; Region: Sulf_transp; pfam04143 862908003455 4 probable transmembrane helices predicted for BMS0889 by TMHMM2.0 at aa 13-35, 55-77, 84-102 and 117-136 862908003456 HMMPfam hit to PF04143, YeeE/YedE, score 7.5e-15 862908003457 Predicted transporter component [General function prediction only]; Region: COG2391 862908003458 Sulphur transport; Region: Sulf_transp; pfam04143 862908003459 Signal peptide predicted for BMS0890 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.395 between residues 21 and 22 862908003460 4 probable transmembrane helices predicted for BMS0890 by TMHMM2.0 at aa 5-23, 38-60, 83-105 and 110-129 862908003461 HMMPfam hit to PF04143, YeeE/YedE, score 6e-11 862908003462 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 862908003463 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 862908003464 Signal peptide predicted for BMS0891 by SignalP 2.0 HMM (Signal peptide probability 0.821) with cleavage site probability 0.731 between residues 20 and 21 862908003465 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 862908003466 Signal peptide predicted for BMS0892 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.870 between residues 18 and 19 862908003467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908003468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908003469 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862908003470 putative effector binding pocket; other site 862908003471 dimerization interface [polypeptide binding]; other site 862908003472 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.5e-33 862908003473 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.8e-17 862908003474 YceI-like domain; Region: YceI; pfam04264 862908003475 Signal peptide predicted for BMS0894 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.921 between residues 18 and 19 862908003476 Pirin-related protein [General function prediction only]; Region: COG1741 862908003477 Pirin; Region: Pirin; pfam02678 862908003478 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 862908003479 HMMPfam hit to PF02678, Pirin, N-terminal, score 1.9e-40 862908003480 HMMPfam hit to PF05726, Pirin, C-terminal, score 1.3e-27 862908003481 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 862908003482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908003483 ATP binding site [chemical binding]; other site 862908003484 putative Mg++ binding site [ion binding]; other site 862908003485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908003486 nucleotide binding region [chemical binding]; other site 862908003487 ATP-binding site [chemical binding]; other site 862908003488 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 862908003489 HRDC domain; Region: HRDC; pfam00570 862908003490 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 6.2e-29 862908003491 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.2e-28 862908003492 HMMPfam hit to PF00570, HRDC, score 1.2e-15 862908003493 MASE1; Region: MASE1; pfam05231 862908003494 CHASE domain; Region: CHASE; pfam03924 862908003495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908003496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908003497 dimer interface [polypeptide binding]; other site 862908003498 phosphorylation site [posttranslational modification] 862908003499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908003500 ATP binding site [chemical binding]; other site 862908003501 Mg2+ binding site [ion binding]; other site 862908003502 G-X-G motif; other site 862908003503 Response regulator receiver domain; Region: Response_reg; pfam00072 862908003504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908003505 active site 862908003506 phosphorylation site [posttranslational modification] 862908003507 intermolecular recognition site; other site 862908003508 dimerization interface [polypeptide binding]; other site 862908003509 HMMPfam hit to PF00072, Response regulator receiver, score 5.7e-27 862908003510 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.5e-39 862908003511 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.4e-21 862908003512 7 probable transmembrane helices predicted for BMS0897 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 125-147, 154-176, 191-210 and 496-518 862908003513 HMMPfam hit to PF03924, CHASE, score 2.6e-06 862908003514 HMMPfam hit to PF05231, MASE1, score 8.4e-18 862908003515 Signal peptide predicted for BMS0897 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.728 between residues 35 and 36 862908003516 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 862908003517 S1 domain; Region: S1_2; pfam13509 862908003518 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908003519 Signal peptide predicted for BMS0899 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.762 between residues 16 and 17 862908003520 Bacterial SH3 domain; Region: SH3_3; cl17532 862908003521 Signal peptide predicted for BMS0900 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.714 between residues 23 and 24 862908003522 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 862908003523 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 862908003524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908003525 Coenzyme A binding pocket [chemical binding]; other site 862908003526 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.4e-05 862908003527 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 862908003528 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 862908003529 Na binding site [ion binding]; other site 862908003530 Signal peptide predicted for BMS0905 by SignalP 2.0 HMM (Signal peptide probability 0.871) with cleavage site probability 0.322 between residues 23 and 24 862908003531 13 probable transmembrane helices predicted for BMS0905 by TMHMM2.0 at aa 5-22, 42-64, 68-90, 120-138, 158-180, 187-209, 235-257, 277-299, 309-331, 360-382, 392-411, 418-437 and 442-461 862908003532 HMMPfam hit to PF00474, Na+/solute symporter, score 9.5e-44 862908003533 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862908003534 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908003535 3 probable transmembrane helices predicted for BMS0906 by TMHMM2.0 at aa 5-27, 76-98 and 103-125 862908003536 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.1e-19 862908003537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908003538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908003539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908003540 dimerization interface [polypeptide binding]; other site 862908003541 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.1e-15 862908003542 PS00044 Bacterial regulatory proteins, lysR family signature. 862908003543 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 862908003544 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862908003545 9 probable transmembrane helices predicted for BMS0910 by TMHMM2.0 at aa 15-32, 45-64, 68-90, 134-156, 171-193, 214-233, 248-270, 283-302 and 312-334 862908003546 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 862908003547 4 probable transmembrane helices predicted for BMS0911 by TMHMM2.0 at aa 47-69, 79-98, 110-132 and 142-161 862908003548 7 probable transmembrane helices predicted for BMS0912 by TMHMM2.0 at aa 4-26, 35-57, 61-83, 95-117, 137-156, 177-199 and 214-236 862908003549 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908003551 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 862908003552 Walker A/P-loop; other site 862908003553 ATP binding site [chemical binding]; other site 862908003554 Q-loop/lid; other site 862908003555 ABC transporter signature motif; other site 862908003556 Walker B; other site 862908003557 D-loop; other site 862908003558 H-loop/switch region; other site 862908003559 HMMPfam hit to PF00005, ABC transporter, score 4.2e-18 862908003560 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003561 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862908003562 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862908003563 intersubunit interface [polypeptide binding]; other site 862908003564 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 1.8e-28 862908003565 Signal peptide predicted for BMS0914 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 19 and 20 862908003566 Signal peptide predicted for BMS0915 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 17 and 18 862908003567 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 862908003568 active site clefts [active] 862908003569 zinc binding site [ion binding]; other site 862908003570 dimer interface [polypeptide binding]; other site 862908003571 HMMPfam hit to PF00484, Carbonic anhydrase, prokaryotic and plant, score 3.7e-45 862908003572 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 862908003573 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862908003574 HMMPfam hit to PF01738, Dienelactone hydrolase, score 5.3e-27 862908003575 Signal peptide predicted for BMS0917 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.974 between residues 18 and 19 862908003576 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 862908003577 4 probable transmembrane helices predicted for BMS0918 by TMHMM2.0 at aa 49-71, 94-116, 129-148 and 154-176 862908003578 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862908003579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908003580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908003581 DNA binding residues [nucleotide binding] 862908003582 HMMPfam hit to PF04542, Sigma-70 region 2, score 7.1e-11 862908003583 Signal peptide predicted for BMS0920 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.996 between residues 28 and 29 862908003584 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 862908003585 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 862908003586 HMMPfam hit to PF03971, Isocitrate dehydrogenase NADP-dependent, monomeric type, score 0 862908003587 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 862908003588 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 862908003589 putative active site [active] 862908003590 Zn binding site [ion binding]; other site 862908003591 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 3.3e-41 862908003592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862908003593 1 probable transmembrane helix predicted for BMS0925 by TMHMM2.0 at aa 7-26 862908003594 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908003595 HMMPfam hit to PF00873, Acriflavin resistance protein, score 6.6e-42 862908003596 12 probable transmembrane helices predicted for BMS0926 by TMHMM2.0 at aa 7-29, 335-357, 359-381, 385-407, 428-450, 460-482, 525-543, 850-869, 871-893, 903-925, 946-968 and 983-1005 862908003597 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003598 8 probable transmembrane helices predicted for BMS0927 by TMHMM2.0 at aa 15-32, 39-61, 71-93, 114-136, 151-168, 180-202, 217-239 and 244-266 862908003599 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 862908003600 short chain dehydrogenase; Provisional; Region: PRK06197 862908003601 putative NAD(P) binding site [chemical binding]; other site 862908003602 active site 862908003603 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2e-24 862908003604 Yqey-like protein; Region: YqeY; cl17540 862908003605 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 862908003606 HMMPfam hit to PF06520, Protein of unknown function DUF1105, score 0.00043 862908003607 Signal peptide predicted for BMS0931 by SignalP 2.0 HMM (Signal peptide probability 0.905) with cleavage site probability 0.797 between residues 18 and 19 862908003608 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862908003609 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase (SpoU), score 7.6e-16 862908003610 1 probable transmembrane helix predicted for BMS0933 by TMHMM2.0 at aa 13-30 862908003611 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 862908003612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908003613 active site 862908003614 nucleotide binding site [chemical binding]; other site 862908003615 HIGH motif; other site 862908003616 KMSKS motif; other site 862908003617 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 862908003618 tRNA binding surface [nucleotide binding]; other site 862908003619 anticodon binding site; other site 862908003620 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 5.5e-09 862908003621 PS00190 Cytochrome c family heme-binding site signature. 862908003622 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 862908003623 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862908003624 interface (dimer of trimers) [polypeptide binding]; other site 862908003625 Substrate-binding/catalytic site; other site 862908003626 Zn-binding sites [ion binding]; other site 862908003627 HMMPfam hit to PF00883, Peptidase M17, cytosol aminopeptidase, C-terminal, score 5.4e-125 862908003628 PS00631 Cytosol aminopeptidase signature. 862908003629 hypothetical protein; Validated; Region: PRK00029 862908003630 Uncharacterized conserved protein [Function unknown]; Region: COG0397 862908003631 HMMPfam hit to PF02696, Protein of unknown function UPF0061, score 1.1e-102 862908003632 Signal peptide predicted for BMS0938 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.613 between residues 21 and 22 862908003633 Protein of unknown function, DUF393; Region: DUF393; cl01136 862908003634 1 probable transmembrane helix predicted for BMS0939 by TMHMM2.0 at aa 84-106 862908003635 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 862908003636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908003637 S-adenosylmethionine binding site [chemical binding]; other site 862908003638 HMMPfam hit to PF05175, Methyltransferase small, score 6.7e-06 862908003639 PS00092 N-6 Adenine-specific DNA methylases signature. 862908003640 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 862908003641 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 862908003642 GTP/Mg2+ binding site [chemical binding]; other site 862908003643 G4 box; other site 862908003644 G5 box; other site 862908003645 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 862908003646 G1 box; other site 862908003647 G1 box; other site 862908003648 GTP/Mg2+ binding site [chemical binding]; other site 862908003649 Switch I region; other site 862908003650 G2 box; other site 862908003651 G2 box; other site 862908003652 G3 box; other site 862908003653 G3 box; other site 862908003654 Switch II region; other site 862908003655 Switch II region; other site 862908003656 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 7e-16 862908003657 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003658 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 862908003659 catalytic site [active] 862908003660 putative active site [active] 862908003661 putative substrate binding site [chemical binding]; other site 862908003662 HMMPfam hit to PF01612, 3'-5' exonuclease, score 7.6e-13 862908003663 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 862908003664 putative substrate binding pocket [chemical binding]; other site 862908003665 AC domain interface; other site 862908003666 catalytic triad [active] 862908003667 AB domain interface; other site 862908003668 HMMPfam hit to PF01470, Peptidase C15, pyroglutamyl peptidase I, score 1.1e-16 862908003669 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 862908003670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862908003671 DNA-binding site [nucleotide binding]; DNA binding site 862908003672 RNA-binding motif; other site 862908003673 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 4.5e-28 862908003674 PS00352 'Cold-shock' DNA-binding domain signature. 862908003675 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862908003676 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862908003677 ATP binding site [chemical binding]; other site 862908003678 Mg++ binding site [ion binding]; other site 862908003679 motif III; other site 862908003680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908003681 nucleotide binding region [chemical binding]; other site 862908003682 ATP-binding site [chemical binding]; other site 862908003683 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 4.3e-66 862908003684 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003685 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 862908003686 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.5e-33 862908003687 3 probable transmembrane helices predicted for BMS0948 by TMHMM2.0 at aa 54-76, 81-103 and 118-135 862908003688 sphingolipid delta-4 desaturase; Region: PLN02579 862908003689 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 862908003690 putative di-iron ligands [ion binding]; other site 862908003691 HMMPfam hit to PF00487, Fatty acid desaturase, score 1.8e-32 862908003692 4 probable transmembrane helices predicted for BMS0949 by TMHMM2.0 at aa 39-58, 63-85, 97-119 and 188-210 862908003693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862908003694 metal-binding site [ion binding] 862908003695 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 0.0002 862908003696 PS01047 Heavy-metal-associated domain. 862908003697 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862908003698 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862908003699 metal-binding site [ion binding] 862908003700 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862908003701 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862908003702 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 4.5e-05 862908003703 PS01047 Heavy-metal-associated domain. 862908003704 8 probable transmembrane helices predicted for BMS0951 by TMHMM2.0 at aa 78-97, 107-124, 145-167, 177-194, 328-350, 363-385, 665-687 and 691-713 862908003705 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 2.6e-78 862908003706 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.7e-35 862908003707 PS00154 E1-E2 ATPases phosphorylation site. 862908003708 PS01229 Hypothetical cof family signature 2. 862908003709 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 862908003710 putative homodimer interface [polypeptide binding]; other site 862908003711 putative homotetramer interface [polypeptide binding]; other site 862908003712 putative allosteric switch controlling residues; other site 862908003713 putative metal binding site [ion binding]; other site 862908003714 putative homodimer-homodimer interface [polypeptide binding]; other site 862908003715 HMMPfam hit to PF02583, Protein of unknown function DUF156, score 1.6e-16 862908003716 MAPEG family; Region: MAPEG; cl09190 862908003717 HMMPfam hit to PF06561, Protein of unknown function DUF1123, score 9.3e-25 862908003718 3 probable transmembrane helices predicted for BMS0954 by TMHMM2.0 at aa 4-26, 72-94 and 114-136 862908003719 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 862908003720 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 4.2e-13 862908003721 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908003722 active site 862908003723 Zn binding site [ion binding]; other site 862908003724 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 5.2e-09 862908003725 Signal peptide predicted for BMS0956 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.784 between residues 19 and 20 862908003726 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 862908003727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908003728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908003729 ABC transporter; Region: ABC_tran_2; pfam12848 862908003730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908003731 HMMPfam hit to PF00005, ABC transporter, score 1.3e-16 862908003732 HMMPfam hit to PF00005, ABC transporter, score 4.7e-40 862908003733 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003734 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908003735 putative catalytic site [active] 862908003736 putative metal binding site [ion binding]; other site 862908003737 putative phosphate binding site [ion binding]; other site 862908003738 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 5.7e-46 862908003739 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 862908003740 Signal peptide predicted for BMS0959 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.483 between residues 62 and 63 862908003741 HMMPfam hit to PF03631, Ribonuclease BN, score 5.6e-07 862908003742 6 probable transmembrane helices predicted for BMS0959 by TMHMM2.0 at aa 44-66, 116-138, 158-180, 195-217, 230-252 and 267-289 862908003743 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003744 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 862908003745 PLD-like domain; Region: PLDc_2; pfam13091 862908003746 putative active site [active] 862908003747 catalytic site [active] 862908003748 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908003749 PLD-like domain; Region: PLDc_2; pfam13091 862908003750 putative active site [active] 862908003751 catalytic site [active] 862908003752 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 1.1 862908003753 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.014 862908003754 Signal peptide predicted for BMS0960 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.661 between residues 19 and 20 862908003755 threonine dehydratase; Provisional; Region: PRK08198 862908003756 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862908003757 tetramer interface [polypeptide binding]; other site 862908003758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908003759 catalytic residue [active] 862908003760 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 862908003761 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2.5e-09 862908003762 HMMPfam hit to PF00291, Pyridoxal-5'-phosphate-dependent enzyme, beta subunit, score 5.2e-92 862908003763 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 862908003764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908003765 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 862908003766 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 3.3e-23 862908003767 Signal peptide predicted for BMS0964 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28 862908003768 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 862908003769 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 6.7e-36 862908003770 3 probable transmembrane helices predicted for BMS0965 by TMHMM2.0 at aa 5-27, 32-54 and 75-97 862908003771 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 862908003772 putative rRNA binding site [nucleotide binding]; other site 862908003773 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 1.5e-11 862908003774 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 862908003775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 862908003776 ATP binding site [chemical binding]; other site 862908003777 putative Mg++ binding site [ion binding]; other site 862908003778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908003779 nucleotide binding region [chemical binding]; other site 862908003780 ATP-binding site [chemical binding]; other site 862908003781 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 862908003782 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 862908003783 RxxxH motif; other site 862908003784 HMMPfam hit to PF01424, Single-stranded nucleic acid binding R3H, score 5.7e-05 862908003785 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.6e-35 862908003786 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 2.3e-50 862908003787 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 862908003788 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908003790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862908003791 dimer interface [polypeptide binding]; other site 862908003792 phosphorylation site [posttranslational modification] 862908003793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908003794 ATP binding site [chemical binding]; other site 862908003795 Mg2+ binding site [ion binding]; other site 862908003796 G-X-G motif; other site 862908003797 5 probable transmembrane helices predicted for BMS0968 by TMHMM2.0 at aa 30-52, 64-86, 101-123, 135-157 and 167-186 862908003798 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0039 862908003799 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.9e-22 862908003800 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 862908003801 HMMPfam hit to PF00639, PpiC-type peptidyl-prolyl cis-trans isomerase, score 9.6e-27 862908003802 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 862908003803 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 862908003804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908003805 ATP binding site [chemical binding]; other site 862908003806 putative Mg++ binding site [ion binding]; other site 862908003807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908003808 nucleotide binding region [chemical binding]; other site 862908003809 ATP-binding site [chemical binding]; other site 862908003810 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 2.4e-37 862908003811 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 4.1e-12 862908003812 HMMPfam hit to PF00271, Helicase, C-terminal, score 4.1e-11 862908003813 Signal peptide predicted for BMS0971 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.953 between residues 17 and 18 862908003814 3 probable transmembrane helices predicted for BMS0972 by TMHMM2.0 at aa 13-35, 45-59 and 102-119 862908003815 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862908003816 Signal peptide predicted for BMS0974 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.883 between residues 17 and 18 862908003817 FecR protein; Region: FecR; pfam04773 862908003818 urocanate hydratase; Provisional; Region: PRK05414 862908003819 HMMPfam hit to PF01175, Urocanase, score 9.4e-115 862908003820 Thioredoxin; Region: Thioredoxin_4; pfam13462 862908003821 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 862908003822 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.4e-05 862908003823 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 862908003824 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 3.3e-25 862908003825 4 probable transmembrane helices predicted for BMS0982 by TMHMM2.0 at aa 20-42, 57-74, 81-103 and 127-149 862908003826 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908003827 active site 862908003828 Zn binding site [ion binding]; other site 862908003829 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 2.5e-65 862908003830 Signal peptide predicted for BMS0983 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.518 between residues 20 and 21 862908003831 Signal peptide predicted for BMS0984 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.941 between residues 17 and 18 862908003832 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 862908003833 HMMPfam hit to PF00639, PpiC-type peptidyl-prolyl cis-trans isomerase, score 6.3e-32 862908003834 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 862908003835 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 862908003836 active site 862908003837 metal binding site [ion binding]; metal-binding site 862908003838 acetyl-CoA synthetase; Provisional; Region: PRK00174 862908003839 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 862908003840 active site 862908003841 CoA binding site [chemical binding]; other site 862908003842 acyl-activating enzyme (AAE) consensus motif; other site 862908003843 AMP binding site [chemical binding]; other site 862908003844 acetate binding site [chemical binding]; other site 862908003845 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4.7e-124 862908003846 PS00455 Putative AMP-binding domain signature. 862908003847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908003849 NAD(P) binding site [chemical binding]; other site 862908003850 active site 862908003851 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 862908003852 GH3 auxin-responsive promoter; Region: GH3; pfam03321 862908003853 HMMPfam hit to PF03321, GH3 auxin-responsive promoter, score 0.0013 862908003854 5 probable transmembrane helices predicted for BMS0991 by TMHMM2.0 at aa 5-27, 42-61, 74-93, 108-130 and 143-165 862908003855 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862908003856 active site 862908003857 Signal peptide predicted for BMS0992 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.646 between residues 24 and 25 862908003858 Predicted flavoprotein [General function prediction only]; Region: COG0431 862908003859 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862908003860 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 8e-07 862908003861 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908003862 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908003863 active site 862908003864 HMMPfam hit to PF00849, Pseudouridine synthase, score 3.3e-24 862908003865 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908003866 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908003867 active site 862908003868 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.6e-19 862908003869 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 862908003870 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 862908003871 HMMPfam hit to PF01545, Cation efflux protein, score 2.8e-73 862908003872 5 probable transmembrane helices predicted for BMS0997 by TMHMM2.0 at aa 20-42, 85-107, 117-139, 152-174 and 179-201 862908003873 Signal peptide predicted for BMS0998 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.876 between residues 19 and 20 862908003874 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 862908003875 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 862908003876 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 862908003877 12 probable transmembrane helices predicted for BMS1001 by TMHMM2.0 at aa 28-47, 359-381, 386-403, 413-432, 468-490, 505-527, 552-574, 896-915, 922-944, 948-970, 997-1019 and 1029-1051 862908003878 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003879 4 probable transmembrane helices predicted for BMS1002 by TMHMM2.0 at aa 15-37, 44-63, 78-95 and 102-124 862908003880 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862908003881 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 862908003882 cation binding site [ion binding]; other site 862908003883 12 probable transmembrane helices predicted for BMS1004 by TMHMM2.0 at aa 13-35, 50-72, 93-115, 125-147, 160-179, 189-211, 237-259, 274-296, 317-339, 354-376, 383-405 and 415-437 862908003884 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 9.7e-23 862908003885 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 7e-26 862908003886 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 862908003887 11 probable transmembrane helices predicted for BMS1005 by TMHMM2.0 at aa 15-37, 222-241, 246-268, 275-297, 350-372, 407-425, 608-627, 632-654, 664-686, 707-726 and 736-758 862908003888 Signal peptide predicted for BMS1005 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.323 between residues 37 and 38 862908003889 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862908003890 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 862908003891 DNA binding residues [nucleotide binding] 862908003892 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862908003893 1 probable transmembrane helix predicted for BMS1008 by TMHMM2.0 at aa 15-34 862908003894 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908003895 Signal peptide predicted for BMS1009 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.673 between residues 23 and 24 862908003896 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 862908003897 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 862908003898 NodB motif; other site 862908003899 active site 862908003900 catalytic site [active] 862908003901 metal binding site [ion binding]; metal-binding site 862908003902 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 3.1e-23 862908003903 Signal peptide predicted for BMS1010 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 19 and 20 862908003904 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 862908003905 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 2.9e-83 862908003906 PS00697 ATP-dependent DNA ligase AMP-binding site. 862908003907 PS00017 ATP/GTP-binding site motif A (P-loop). 862908003908 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908003909 HD domain; Region: HD_5; pfam13487 862908003910 HMMPfam hit to PF00072, Response regulator receiver, score 0.0046 862908003911 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908003912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908003913 Zn2+ binding site [ion binding]; other site 862908003914 Mg2+ binding site [ion binding]; other site 862908003915 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 862908003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908003917 GAF domain; Region: GAF; pfam01590 862908003918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908003919 dimer interface [polypeptide binding]; other site 862908003920 phosphorylation site [posttranslational modification] 862908003921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908003922 ATP binding site [chemical binding]; other site 862908003923 Mg2+ binding site [ion binding]; other site 862908003924 G-X-G motif; other site 862908003925 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2e-08 862908003926 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3e-17 862908003927 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908003928 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908003929 active site 862908003930 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908003931 Signal peptide predicted for BMS1016 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.622 between residues 24 and 25 862908003932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862908003933 active site 862908003934 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 1.8e-16 862908003935 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 862908003936 dimer interface [polypeptide binding]; other site 862908003937 Citrate synthase; Region: Citrate_synt; pfam00285 862908003938 active site 862908003939 citrylCoA binding site [chemical binding]; other site 862908003940 NADH binding [chemical binding]; other site 862908003941 cationic pore residues; other site 862908003942 oxalacetate/citrate binding site [chemical binding]; other site 862908003943 coenzyme A binding site [chemical binding]; other site 862908003944 catalytic triad [active] 862908003945 HMMPfam hit to PF00285, Citrate synthase, score 4.9e-174 862908003946 PS00480 Citrate synthase signature. 862908003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908003948 S-adenosylmethionine binding site [chemical binding]; other site 862908003949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908003950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908003951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908003952 dimerization interface [polypeptide binding]; other site 862908003953 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.5e-06 862908003954 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.3e-17 862908003955 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 862908003956 HMMPfam hit to PF01197, Ribosomal protein L31, score 1.5e-20 862908003957 PS01143 Ribosomal protein L31 signature. 862908003958 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 862908003959 HMMPfam hit to PF00471, Ribosomal protein L33, score 1.7e-18 862908003960 Response regulator receiver domain; Region: Response_reg; pfam00072 862908003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908003962 active site 862908003963 phosphorylation site [posttranslational modification] 862908003964 intermolecular recognition site; other site 862908003965 dimerization interface [polypeptide binding]; other site 862908003966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908003967 Zn2+ binding site [ion binding]; other site 862908003968 Mg2+ binding site [ion binding]; other site 862908003969 HMMPfam hit to PF00072, Response regulator receiver, score 0.00014 862908003970 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 4.7e-07 862908003971 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 862908003972 1 probable transmembrane helix predicted for BMS1025 by TMHMM2.0 at aa 12-34 862908003973 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 862908003974 3 probable transmembrane helices predicted for BMS1026 by TMHMM2.0 at aa 5-27, 108-130 and 150-172 862908003975 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 2.2e-30 862908003976 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 862908003977 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 862908003978 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.3e-29 862908003979 1 probable transmembrane helix predicted for BMS1027 by TMHMM2.0 at aa 13-35 862908003980 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 862908003981 catalytic triad [active] 862908003982 putative active site [active] 862908003983 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 862908003984 Signal peptide predicted for BMS1029 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.812 between residues 21 and 22 862908003985 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.8e-69 862908003986 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908003987 PS00137 Serine proteases, subtilase family, histidine active site. 862908003988 PS00138 Serine proteases, subtilase family, serine active site. 862908003989 HMMPfam hit to PF00431, CUB, score 0.0033 862908003990 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 862908003991 HMMPfam hit to PF03061, Thioesterase superfamily, score 5.4e-15 862908003992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862908003993 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908003994 active site 862908003995 metal binding site [ion binding]; metal-binding site 862908003996 Signal peptide predicted for BMS1031 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.711 between residues 22 and 23 862908003997 HMMPfam hit to PF00149, Metallophosphoesterase, score 0.00031 862908003998 4 probable transmembrane helices predicted for BMS1032 by TMHMM2.0 at aa 66-88, 98-120, 148-170 and 203-225 862908003999 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 862908004000 HMMPfam hit to PF00830, Ribosomal protein L28, score 5.4e-25 862908004001 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 862908004002 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908004003 1 probable transmembrane helix predicted for BMS1036 by TMHMM2.0 at aa 5-24 862908004004 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 862908004005 HMMPfam hit to PF04055, Radical SAM, score 0.011 862908004006 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862908004007 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862908004008 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862908004009 active site 862908004010 catalytic tetrad [active] 862908004011 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.1e-30 862908004012 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862908004013 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 862908004014 active site 862908004015 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 6.7e-47 862908004016 PS00237 G-protein coupled receptors signature. 862908004017 Signal peptide predicted for BMS1041 by SignalP 2.0 HMM (Signal peptide probability 0.855) with cleavage site probability 0.458 between residues 23 and 24 862908004018 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 862908004019 active site 862908004020 ligand binding site [chemical binding]; other site 862908004021 homodimer interface [polypeptide binding]; other site 862908004022 NAD(P) binding site [chemical binding]; other site 862908004023 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal, score 8.2e-09 862908004024 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal, score 2.6e-18 862908004025 Signal peptide predicted for BMS1043 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 17 and 18 862908004026 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 862908004027 active site 862908004028 metal binding site [ion binding]; metal-binding site 862908004029 HMMPfam hit to PF00850, Histone deacetylase superfamily, score 2.1e-07 862908004030 5' nucleotidase family; Region: 5_nucleotid; cl17687 862908004031 HMMPfam hit to PF05761, Purine 5'-nucleotidase, score 7.1e-79 862908004032 PS00761 Signal peptidases I signature 3. 862908004033 Signal peptide predicted for BMS1046 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 862908004034 Signal peptide predicted for BMS1047 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.616 between residues 20 and 21 862908004035 SIR2-like domain; Region: SIR2_2; pfam13289 862908004036 Ion channel; Region: Ion_trans_2; pfam07885 862908004037 2 probable transmembrane helices predicted for BMS1054 by TMHMM2.0 at aa 4-23 and 199-221 862908004038 Signal peptide predicted for BMS1054 by SignalP 2.0 HMM (Signal peptide probability 0.607) with cleavage site probability 0.358 between residues 17 and 18 862908004039 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 862908004040 HMMPfam hit to PF04299, Negative transcriptional regulator, score 8.5e-56 862908004041 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 862908004042 Signal peptide predicted for BMS1056 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.955 between residues 18 and 19 862908004043 HMMPfam hit to PF01373, Glycoside hydrolase, family 14, score 2.6e-99 862908004044 PS00506 Beta-amylase active site 1. 862908004045 PS00679 Beta-amylase active site 2. 862908004046 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 862908004047 active site 862908004048 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004049 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 862908004050 Signal peptide predicted for BMS1059 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.524 between residues 21 and 22 862908004051 6 probable transmembrane helices predicted for BMS1059 by TMHMM2.0 at aa 5-23, 38-60, 72-94, 128-145, 165-187 and 202-224 862908004052 Signal peptide predicted for BMS1060 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 18 and 19 862908004053 4 probable transmembrane helices predicted for BMS1061 by TMHMM2.0 at aa 4-22, 27-49, 64-81 and 88-110 862908004054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908004055 Coenzyme A binding pocket [chemical binding]; other site 862908004056 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908004057 Signal peptide predicted for BMS1063 by SignalP 2.0 HMM (Signal peptide probability 0.835) with cleavage site probability 0.426 between residues 17 and 18 862908004058 Signal peptide predicted for BMS1064 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.824 between residues 16 and 17 862908004059 Signal peptide predicted for BMS1065 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.968 between residues 60 and 61 862908004060 6 probable transmembrane helices predicted for BMS1067 by TMHMM2.0 at aa 20-42, 63-85, 95-114, 127-149, 188-207 and 219-236 862908004061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908004062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908004063 LysR substrate binding domain; Region: LysR_substrate; pfam03466 862908004064 dimerization interface [polypeptide binding]; other site 862908004065 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.9e-07 862908004066 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.4e-06 862908004067 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 862908004068 HMMPfam hit to PF06772, Bacterial low temperature requirement A, score 2.5e-34 862908004069 11 probable transmembrane helices predicted for BMS1069 by TMHMM2.0 at aa 21-43, 48-70, 83-105, 110-132, 144-163, 167-184, 229-251, 266-288, 305-327, 337-355 and 360-382 862908004070 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 862908004071 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 862908004072 Cl- selectivity filter; other site 862908004073 Cl- binding residues [ion binding]; other site 862908004074 pore gating glutamate residue; other site 862908004075 dimer interface [polypeptide binding]; other site 862908004076 10 probable transmembrane helices predicted for BMS1070 by TMHMM2.0 at aa 29-51, 64-83, 103-125, 156-178, 191-210, 230-249, 270-292, 330-352, 357-379 and 384-406 862908004077 HMMPfam hit to PF00654, Cl- channel, voltage gated, score 2.8e-26 862908004078 topology modulation protein; Provisional; Region: PRK07261 862908004079 AAA domain; Region: AAA_17; pfam13207 862908004080 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004081 Peptidase M15; Region: Peptidase_M15_3; cl01194 862908004082 Signal peptide predicted for BMS1074 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.851 between residues 24 and 25 862908004083 Signal peptide predicted for BMS1075 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.957 between residues 18 and 19 862908004084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908004085 AAA domain; Region: AAA_22; pfam13401 862908004086 Walker A motif; other site 862908004087 ATP binding site [chemical binding]; other site 862908004088 Walker B motif; other site 862908004089 6 probable transmembrane helices predicted for BMS1077 by TMHMM2.0 at aa 400-422, 458-477, 482-504, 524-546, 550-569 and 608-625 862908004090 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004091 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908004092 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862908004093 3 probable transmembrane helices predicted for BMS1078 by TMHMM2.0 at aa 15-37, 58-77 and 92-114 862908004094 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 3.1e-29 862908004095 PAS domain; Region: PAS_9; pfam13426 862908004096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908004097 putative active site [active] 862908004098 heme pocket [chemical binding]; other site 862908004099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908004100 PAS domain; Region: PAS_9; pfam13426 862908004101 putative active site [active] 862908004102 heme pocket [chemical binding]; other site 862908004103 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862908004104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908004105 putative active site [active] 862908004106 heme pocket [chemical binding]; other site 862908004107 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862908004108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908004109 putative active site [active] 862908004110 heme pocket [chemical binding]; other site 862908004111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908004112 putative active site [active] 862908004113 heme pocket [chemical binding]; other site 862908004114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908004115 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862908004116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908004117 dimer interface [polypeptide binding]; other site 862908004118 putative CheW interface [polypeptide binding]; other site 862908004119 HMMPfam hit to PF00785, PAC motif, score 0.00016 862908004120 HMMPfam hit to PF00785, PAC motif, score 1.2e-09 862908004121 HMMPfam hit to PF00785, PAC motif, score 7.1e-06 862908004122 HMMPfam hit to PF00785, PAC motif, score 2.1e-05 862908004123 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 1.6e-68 862908004124 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862908004125 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862908004126 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 862908004127 HMMPfam hit to PF03705, MCP methyltransferase, CheR-type, score 5.8e-11 862908004128 HMMPfam hit to PF01739, MCP methyltransferase, CheR-type, score 9.7e-44 862908004129 CheD chemotactic sensory transduction; Region: CheD; cl00810 862908004130 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 862908004131 CheW-like domain; Region: CheW; pfam01584 862908004132 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862908004133 HMMPfam hit to PF01584, CheW-like protein, score 3e-18 862908004134 HMMPfam hit to PF01584, CheW-like protein, score 1.1e-13 862908004135 HMMPfam hit to PF01584, CheW-like protein, score 1.3e-14 862908004136 Signal peptide predicted for BMS1083 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.618 between residues 17 and 18 862908004137 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908004138 SWIB/MDM2 domain; Region: SWIB; cl02489 862908004139 HMMPfam hit to PF02201, SWIB complex, BAF60b, score 9.2e-07 862908004140 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908004141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908004142 substrate binding pocket [chemical binding]; other site 862908004143 membrane-bound complex binding site; other site 862908004144 hinge residues; other site 862908004145 Signal peptide predicted for BMS1085 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.991 between residues 19 and 20 862908004146 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 862908004147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908004148 S-adenosylmethionine binding site [chemical binding]; other site 862908004149 HMMPfam hit to PF01596, O-methyltransferase, family 3, score 3.7e-52 862908004150 TM2 domain; Region: TM2; cl00984 862908004151 TM2 domain; Region: TM2; cl00984 862908004152 HMMPfam hit to PF05154, TM2, score 3.3e-14 862908004153 4 probable transmembrane helices predicted for BMS1087 by TMHMM2.0 at aa 20-37, 42-64, 79-98 and 105-127 862908004154 HMMPfam hit to PF05154, TM2, score 6.6e-14 862908004155 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862908004156 active site 862908004157 catalytic site [active] 862908004158 Signal peptide predicted for BMS1088 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.996 between residues 17 and 18 862908004159 Signal peptide predicted for BMS1089 by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.935 between residues 31 and 32 862908004160 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 862908004161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908004162 dimer interface [polypeptide binding]; other site 862908004163 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862908004164 putative CheW interface [polypeptide binding]; other site 862908004165 Signal peptide predicted for BMS1091 by SignalP 2.0 HMM (Signal peptide probability 0.787) with cleavage site probability 0.554 between residues 44 and 45 862908004166 2 probable transmembrane helices predicted for BMS1091 by TMHMM2.0 at aa 23-45 and 330-352 862908004167 PS00107 Protein kinases ATP-binding region signature. 862908004168 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 6.9e-41 862908004169 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908004170 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908004171 Signal peptide predicted for BMS1092 by SignalP 2.0 HMM (Signal peptide probability 0.925) with cleavage site probability 0.623 between residues 20 and 21 862908004172 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004173 HMMPfam hit to PF01551, Peptidase M23B, score 4.1e-38 862908004174 Protein of unknown function, DUF606; Region: DUF606; pfam04657 862908004175 5 probable transmembrane helices predicted for BMS1093 by TMHMM2.0 at aa 5-24, 34-56, 69-91, 95-114 and 127-146 862908004176 HMMPfam hit to PF04657, Protein of unknown function DUF606, score 2.3e-39 862908004177 Signal peptide predicted for BMS1093 by SignalP 2.0 HMM (Signal peptide probability 0.608) with cleavage site probability 0.402 between residues 21 and 22 862908004178 RmuC family; Region: RmuC; pfam02646 862908004179 1 probable transmembrane helix predicted for BMS1094 by TMHMM2.0 at aa 5-24 862908004180 HMMPfam hit to PF02646, Protein of unknown function DUF195, score 3.3e-57 862908004181 1 probable transmembrane helix predicted for BMS1095 by TMHMM2.0 at aa 7-29 862908004182 Response regulator receiver domain; Region: Response_reg; pfam00072 862908004183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004184 active site 862908004185 phosphorylation site [posttranslational modification] 862908004186 intermolecular recognition site; other site 862908004187 dimerization interface [polypeptide binding]; other site 862908004188 HMMPfam hit to PF00072, Response regulator receiver, score 2.1e-18 862908004189 Predicted esterase [General function prediction only]; Region: COG0400 862908004190 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 6.9e-28 862908004191 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 862908004192 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 862908004193 5S rRNA interface [nucleotide binding]; other site 862908004194 CTC domain interface [polypeptide binding]; other site 862908004195 L16 interface [polypeptide binding]; other site 862908004196 HMMPfam hit to PF01386, Ribosomal protein L25, score 5.1e-11 862908004197 Signal peptide predicted for BMS1099 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.988 between residues 45 and 46 862908004198 PS00687 Aldehyde dehydrogenases glutamic acid active site. 862908004199 Domain of unknown function (DUF955); Region: DUF955; cl01076 862908004200 Signal peptide predicted for BMS1101 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.950 between residues 19 and 20 862908004201 Protein of unknown function (DUF962); Region: DUF962; cl01879 862908004202 HMMPfam hit to PF06127, Protein of unknown function DUF962, score 4e-39 862908004203 5 probable transmembrane helices predicted for BMS1102 by TMHMM2.0 at aa 20-42, 47-69, 74-93, 98-120 and 130-149 862908004204 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 862908004205 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 862908004206 conserved cys residue [active] 862908004207 HMMPfam hit to PF01965, ThiJ/PfpI, score 0.0012 862908004208 Putative methyltransferase; Region: Methyltransf_4; cl17290 862908004209 HMMPfam hit to PF02390, Putative methyltransferase, score 8.1e-11 862908004210 10 probable transmembrane helices predicted for BMS1105 by TMHMM2.0 at aa 4-26, 39-56, 66-88, 95-112, 122-141, 148-170, 185-207, 219-236, 240-262 and 274-290 862908004211 HMMPfam hit to PF00892, Protein of unknown function DUF6, score 3.4e-06 862908004212 glutaredoxin 2; Provisional; Region: PRK10387 862908004213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908004214 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862908004215 dimer interface [polypeptide binding]; other site 862908004216 N-terminal domain interface [polypeptide binding]; other site 862908004217 substrate binding pocket (H-site) [chemical binding]; other site 862908004218 PS00195 Glutaredoxin active site. 862908004219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908004220 putative substrate translocation pore; other site 862908004221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862908004222 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862908004223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862908004224 putative acyl-acceptor binding pocket; other site 862908004225 11 probable transmembrane helices predicted for BMS1107 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 146-168, 172-194, 227-249, 264-281, 294-313, 337-359, 371-393 and 398-420 862908004226 HMMPfam hit to PF07690, , score 1.1e-12 862908004227 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 7.5e-25 862908004228 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 862908004229 trimer interface [polypeptide binding]; other site 862908004230 putative Zn binding site [ion binding]; other site 862908004231 HMMPfam hit to PF03479, Protein of unknown function DUF296, score 3.3e-12 862908004232 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 862908004233 Signal peptide predicted for BMS1111 by SignalP 2.0 HMM (Signal peptide probability 0.788) with cleavage site probability 0.603 between residues 19 and 20 862908004234 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862908004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908004237 HMMPfam hit to PF07690, , score 9.9e-13 862908004238 10 probable transmembrane helices predicted for BMS1112 by TMHMM2.0 at aa 13-33, 43-65, 72-94, 98-120, 214-236, 251-270, 277-296, 301-318, 339-361 and 371-390 862908004239 PS00216 Sugar transport proteins signature 1. 862908004240 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004241 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862908004242 transketolase; Reviewed; Region: PRK05899 862908004243 TPP-binding site [chemical binding]; other site 862908004244 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862908004245 PYR/PP interface [polypeptide binding]; other site 862908004246 dimer interface [polypeptide binding]; other site 862908004247 TPP binding site [chemical binding]; other site 862908004248 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862908004249 HMMPfam hit to PF02780, Transketolase, C terminal, score 3.7e-22 862908004250 HMMPfam hit to PF02779, Transketolase, central region, score 1.4e-11 862908004251 HMMPfam hit to PF00456, Transketolase, N terminal, score 1e-14 862908004252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862908004253 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908004254 NAD(P) binding site [chemical binding]; other site 862908004255 catalytic residues [active] 862908004256 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 4.3e-100 862908004257 PS00687 Aldehyde dehydrogenases glutamic acid active site. 862908004258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908004259 substrate binding pocket [chemical binding]; other site 862908004260 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908004261 membrane-bound complex binding site; other site 862908004262 hinge residues; other site 862908004263 Signal peptide predicted for BMS1117 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.973 between residues 17 and 18 862908004264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 862908004265 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 862908004266 ligand binding site [chemical binding]; other site 862908004267 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908004268 Signal peptide predicted for BMS1118 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.970 between residues 18 and 19 862908004269 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862908004270 1 probable transmembrane helix predicted for BMS1119 by TMHMM2.0 at aa 7-29 862908004271 PS00190 Cytochrome c family heme-binding site signature. 862908004272 PS00190 Cytochrome c family heme-binding site signature. 862908004273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908004274 Coenzyme A binding pocket [chemical binding]; other site 862908004275 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4e-05 862908004276 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862908004277 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862908004278 1 probable transmembrane helix predicted for BMS1123 by TMHMM2.0 at aa 20-39 862908004279 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.4e-77 862908004280 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 862908004281 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862908004282 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862908004283 active site 862908004284 catalytic site [active] 862908004285 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 2.4e-09 862908004286 1 probable transmembrane helix predicted for BMS1126 by TMHMM2.0 at aa 4-23 862908004287 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862908004288 dimer interface [polypeptide binding]; other site 862908004289 ADP-ribose binding site [chemical binding]; other site 862908004290 active site 862908004291 nudix motif; other site 862908004292 metal binding site [ion binding]; metal-binding site 862908004293 HMMPfam hit to PF00293, NUDIX hydrolase, score 6.3e-07 862908004294 PS00893 mutT domain signature. 862908004295 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 862908004296 LabA_like proteins; Region: LabA_like/DUF88; cl10034 862908004297 putative metal binding site [ion binding]; other site 862908004298 Uncharacterized conserved protein [Function unknown]; Region: COG1432 862908004299 HMMPfam hit to PF01936, Protein of unknown function DUF88, score 2e-09 862908004300 HMMPfam hit to PF00036, Calcium-binding EF-hand, score 0.067 862908004301 PS00018 EF-hand calcium-binding domain. 862908004302 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 862908004303 Signal peptide predicted for BMS1129 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.684 between residues 23 and 24 862908004304 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004305 Signal peptide predicted for BMS1130 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 21 and 22 862908004306 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 862908004307 putative acyl-acceptor binding pocket; other site 862908004308 HMMPfam hit to PF04028, Protein of unknown function DUF374, score 1.5e-11 862908004309 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 862908004310 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 862908004311 HMMPfam hit to PF00076, RNA-binding region RNP-1 (RNA recognition motif), score 3.7e-18 862908004312 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 862908004313 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 862908004314 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 862908004315 Signal peptide predicted for BMS1133 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 19 and 20 862908004316 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 862908004317 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 862908004318 DNA binding site [nucleotide binding] 862908004319 catalytic residue [active] 862908004320 H2TH interface [polypeptide binding]; other site 862908004321 putative catalytic residues [active] 862908004322 turnover-facilitating residue; other site 862908004323 intercalation triad [nucleotide binding]; other site 862908004324 8OG recognition residue [nucleotide binding]; other site 862908004325 putative reading head residues; other site 862908004326 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 862908004327 PS00190 Cytochrome c family heme-binding site signature. 862908004328 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, score 1.5e-16 862908004329 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycolase, score 7.6e-21 862908004330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862908004331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908004332 salt bridge; other site 862908004333 non-specific DNA binding site [nucleotide binding]; other site 862908004334 sequence-specific DNA binding site [nucleotide binding]; other site 862908004335 HMMPfam hit to PF01381, Helix-turn-helix motif, score 2.1e-12 862908004336 3 probable transmembrane helices predicted for BMS1139 by TMHMM2.0 at aa 20-34, 47-64 and 69-91 862908004337 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 862908004338 Signal peptide predicted for BMS1141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 862908004339 Phospholipid methyltransferase; Region: PEMT; cl17370 862908004340 HMMPfam hit to PF04140, Isoprenylcysteine carboxyl methyltransferase, score 0.00018 862908004341 3 probable transmembrane helices predicted for BMS1142 by TMHMM2.0 at aa 4-21, 28-47 and 85-107 862908004342 serine/threonine protein kinase; Provisional; Region: PRK11768 862908004343 Phosphotransferase enzyme family; Region: APH; pfam01636 862908004344 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 4e-12 862908004345 Nitronate monooxygenase; Region: NMO; pfam03060 862908004346 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862908004347 FMN binding site [chemical binding]; other site 862908004348 substrate binding site [chemical binding]; other site 862908004349 putative catalytic residue [active] 862908004350 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, NPD, score 3.1e-66 862908004351 PS00912 Dihydroorotate dehydrogenase signature 2. 862908004352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862908004353 putative DNA binding site [nucleotide binding]; other site 862908004354 putative Zn2+ binding site [ion binding]; other site 862908004355 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 6.7e-07 862908004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908004357 putative substrate translocation pore; other site 862908004358 HMMPfam hit to PF07690, , score 1.3e-20 862908004359 10 probable transmembrane helices predicted for BMS1147 by TMHMM2.0 at aa 7-29, 39-56, 63-85, 95-117, 124-146, 168-190, 203-222, 232-254, 261-283 and 319-341 862908004360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908004361 NAD(P) binding site [chemical binding]; other site 862908004362 active site 862908004363 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 862908004364 HMMPfam hit to PF04828, Glutathione-dependent formaldehyde-activating, GFA, score 3.3e-08 862908004365 Rrf2 family protein; Region: rrf2_super; TIGR00738 862908004366 Transcriptional regulator; Region: Rrf2; pfam02082 862908004367 HMMPfam hit to PF02082, Protein of unknown function UPF0074, score 2.5e-27 862908004368 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862908004369 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 9.3e-08 862908004370 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 862908004371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908004372 S-adenosylmethionine binding site [chemical binding]; other site 862908004373 Beta-propeller repeat; Region: SBBP; pfam06739 862908004374 Beta-propeller repeat; Region: SBBP; pfam06739 862908004375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004376 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 862908004377 HMMPfam hit to PF05721, Phytanoyl-CoA dioxygenase, score 4.2e-09 862908004378 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 862908004379 HIT family signature motif; other site 862908004380 catalytic residue [active] 862908004381 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 1.6e-30 862908004382 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 862908004383 Interdomain contacts; other site 862908004384 Cytokine receptor motif; other site 862908004385 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 862908004386 HMMPfam hit to PF00041, Fibronectin, type III, score 1.9e-14 862908004387 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 862908004388 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 862908004389 Signal peptide predicted for BMS1158 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.929 between residues 24 and 25 862908004390 PS00228 Tubulin-beta mRNA autoregulation signal. 862908004391 1 probable transmembrane helix predicted for BMS1160 by TMHMM2.0 at aa 293-315 862908004392 Signal peptide predicted for BMS1161 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.499 between residues 15 and 16 862908004393 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 862908004394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862908004395 dimerization interface [polypeptide binding]; other site 862908004396 putative DNA binding site [nucleotide binding]; other site 862908004397 putative Zn2+ binding site [ion binding]; other site 862908004398 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 2.2e-11 862908004399 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 862908004400 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 862908004401 FMN binding site [chemical binding]; other site 862908004402 active site 862908004403 substrate binding site [chemical binding]; other site 862908004404 catalytic residue [active] 862908004405 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, score 1.1e-95 862908004406 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 862908004407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908004408 FeS/SAM binding site; other site 862908004409 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 862908004410 HMMPfam hit to PF04055, Radical SAM, score 1.1e-12 862908004411 HMMPfam hit to PF06463, Molybdenum cofactor synthesis C, score 5e-32 862908004412 PS00527 Ribosomal protein S14 signature. 862908004413 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional; Region: PRK14500 862908004414 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 862908004415 trimer interface [polypeptide binding]; other site 862908004416 dimer interface [polypeptide binding]; other site 862908004417 putative active site [active] 862908004418 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 862908004419 GTP binding site; other site 862908004420 HMMPfam hit to PF01967, Molybdopterin cofactor biosynthesis protein MoaC, score 1.6e-66 862908004421 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862908004422 MoaE interaction surface [polypeptide binding]; other site 862908004423 MoeB interaction surface [polypeptide binding]; other site 862908004424 thiocarboxylated glycine; other site 862908004425 HMMPfam hit to PF02597, ThiamineS, score 5.1e-15 862908004426 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 862908004427 MoaE homodimer interface [polypeptide binding]; other site 862908004428 MoaD interaction [polypeptide binding]; other site 862908004429 active site residues [active] 862908004430 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 862908004431 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 862908004432 ATP binding site [chemical binding]; other site 862908004433 substrate interface [chemical binding]; other site 862908004434 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862908004435 active site residue [active] 862908004436 HMMPfam hit to PF02391, Molybdopterin biosynthesis MoaE, score 7.7e-47 862908004437 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 1.9e-50 862908004438 HMMPfam hit to PF05237, MoeZ/MoeB, score 0.00016 862908004439 YcaO domain protein; Region: TIGR03549 862908004440 OsmC-like protein; Region: OsmC; pfam02566 862908004441 YcaO-like family; Region: YcaO; pfam02624 862908004442 HMMPfam hit to PF02624, Protein of unknown function DUF181, score 8.1e-131 862908004443 Patatin-like phospholipase; Region: Patatin; pfam01734 862908004444 Signal peptide predicted for BMS1170 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908004445 HMMPfam hit to PF01734, Patatin, score 5.4e-05 862908004446 Signal peptide predicted for BMS1171 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21 862908004447 N-terminal glutamine amidase; Region: Nt_Gln_amidase; pfam09764 862908004448 Signal peptide predicted for BMS1172 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.519 between residues 18 and 19 862908004449 hypothetical protein; Provisional; Region: PRK10621 862908004450 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862908004451 7 probable transmembrane helices predicted for BMS1173 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 102-119, 142-164, 201-223 and 236-253 862908004452 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 1.8e-17 862908004453 1 probable transmembrane helix predicted for BMS1174 by TMHMM2.0 at aa 7-29 862908004454 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 862908004455 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862908004456 FMN binding site [chemical binding]; other site 862908004457 active site 862908004458 catalytic residues [active] 862908004459 substrate binding site [chemical binding]; other site 862908004460 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 2.2e-12 862908004461 PS01136 Uncharacterized protein family UPF0034 signature. 862908004462 Signal peptide predicted for BMS1176 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 19 and 20 862908004463 YaeQ protein; Region: YaeQ; pfam07152 862908004464 HMMPfam hit to PF07152, YaeQ, score 2.5e-62 862908004465 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862908004466 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908004467 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862908004468 N-terminal domain interface [polypeptide binding]; other site 862908004469 dimer interface [polypeptide binding]; other site 862908004470 substrate binding pocket (H-site) [chemical binding]; other site 862908004471 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 4.7e-15 862908004472 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 1.9e-23 862908004473 Signal peptide predicted for BMS1179 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.793 between residues 21 and 22 862908004474 Signal peptide predicted for BMS1180 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.981 between residues 18 and 19 862908004475 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 862908004476 glutaminase; Provisional; Region: PRK00971 862908004477 HMMPfam hit to PF04960, Glutaminase, score 6.6e-169 862908004478 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862908004479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908004480 dimer interface [polypeptide binding]; other site 862908004481 putative CheW interface [polypeptide binding]; other site 862908004482 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 1e-41 862908004483 2 probable transmembrane helices predicted for BMS1182 by TMHMM2.0 at aa 10-29 and 410-432 862908004484 Signal peptide predicted for BMS1182 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.309 between residues 31 and 32 862908004485 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 862908004486 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862908004487 TrkA-C domain; Region: TrkA_C; pfam02080 862908004488 HMMPfam hit to PF02080, TrkA-C, score 3.2e-09 862908004489 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 3.9e-45 862908004490 10 probable transmembrane helices predicted for BMS1183 by TMHMM2.0 at aa 7-29, 39-58, 71-93, 98-120, 168-190, 205-236, 248-270, 280-302, 315-337 and 342-364 862908004491 Signal peptide predicted for BMS1183 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.781 between residues 25 and 26 862908004492 S-formylglutathione hydrolase; Region: PLN02442 862908004493 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 862908004494 HMMPfam hit to PF00756, Putative esterase, score 7.4e-59 862908004495 PS00120 Lipases, serine active site. 862908004496 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 862908004497 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 862908004498 substrate binding site [chemical binding]; other site 862908004499 catalytic Zn binding site [ion binding]; other site 862908004500 NAD binding site [chemical binding]; other site 862908004501 structural Zn binding site [ion binding]; other site 862908004502 dimer interface [polypeptide binding]; other site 862908004503 HMMPfam hit to PF00107, Zinc-containing alcohol dehydrogenase superfamily, score 2e-145 862908004504 PS00059 Zinc-containing alcohol dehydrogenases signature. 862908004505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908004506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908004507 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862908004508 putative effector binding pocket; other site 862908004509 dimerization interface [polypeptide binding]; other site 862908004510 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.7e-18 862908004511 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.9e-25 862908004512 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 862908004513 Cupin-like domain; Region: Cupin_8; pfam13621 862908004514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908004515 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 862908004516 HMMPfam hit to PF03486, HI0933-like protein, score 6.1e-60 862908004517 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 862908004518 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 862908004519 Permutation of conserved domain; other site 862908004520 active site 862908004521 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 862908004522 HMMPfam hit to PF01142, tRNA pseudouridine synthase D, TruD, score 7.7e-96 862908004523 Signal peptide predicted for BMS1192 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 18 and 19 862908004524 NnrS protein; Region: NnrS; pfam05940 862908004525 HMMPfam hit to PF05940, NnrS, score 9.2e-16 862908004526 11 probable transmembrane helices predicted for BMS1193 by TMHMM2.0 at aa 20-42, 54-76, 80-102, 107-129, 139-161, 180-197, 201-218, 230-252, 262-284, 296-318 and 323-345 862908004527 Signal peptide predicted for BMS1195 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.990 between residues 18 and 19 862908004528 Signal peptide predicted for BMS1196 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908004529 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 862908004530 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 862908004531 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 862908004532 HMMPfam hit to PF01346, FKBP-type peptidyl-prolyl isomerase, N-terminal, score 5.2e-17 862908004533 HMMPfam hit to PF00254, Peptidylprolyl isomerase, FKBP-type, score 2.5e-44 862908004534 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 862908004535 Signal peptide predicted for BMS1198 by SignalP 2.0 HMM (Signal peptide probability 0.757) with cleavage site probability 0.332 between residues 21 and 22 862908004536 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004537 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 862908004538 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 862908004539 Signal peptide predicted for BMS1199 by SignalP 2.0 HMM (Signal peptide probability 0.912) with cleavage site probability 0.602 between residues 22 and 23 862908004540 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 7.9e-11 862908004541 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 862908004542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908004543 active site 862908004544 HIGH motif; other site 862908004545 nucleotide binding site [chemical binding]; other site 862908004546 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 862908004547 KMSKS motif; other site 862908004548 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 862908004549 HMMPfam hit to PF00749, Glutamyl-tRNA synthetase, class Ic, score 5.5e-137 862908004550 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 862908004551 HMMPfam hit to PF03950, Glutamyl-tRNA synthetase, class Ic, score 6.7e-79 862908004552 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 862908004553 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862908004554 HIGH motif; other site 862908004555 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862908004556 active site 862908004557 KMSKS motif; other site 862908004558 HMMPfam hit to PF00749, Glutamyl-tRNA synthetase, class Ic, score 3.2e-143 862908004559 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 862908004560 PS00037 Myb DNA-binding domain repeat signature 1. 862908004561 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862908004562 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862908004563 active site 862908004564 HIGH motif; other site 862908004565 dimer interface [polypeptide binding]; other site 862908004566 KMSKS motif; other site 862908004567 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 1.1e-101 862908004568 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862908004569 HMMPfam hit to PF01627, Hpt, score 9.3e-10 862908004570 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 862908004571 hydrophobic ligand binding site; other site 862908004572 Signal peptide predicted for BMS1204 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.985 between residues 16 and 17 862908004573 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 862908004574 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 862908004575 3 probable transmembrane helices predicted for BMS1205 by TMHMM2.0 at aa 84-106, 136-158 and 165-187 862908004576 HMMPfam hit to PF04116, Fatty acid hydroxylase, score 3e-38 862908004577 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 862908004578 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 862908004579 active site 862908004580 Signal peptide predicted for BMS1206 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.872 between residues 20 and 21 862908004581 4 probable transmembrane helices predicted for BMS1206 by TMHMM2.0 at aa 7-29, 87-109, 122-144 and 184-201 862908004582 HMMPfam hit to PF01569, Phosphoesterase, PA-phosphatase related, score 0.00074 862908004583 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908004584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908004585 NAD(P) binding site [chemical binding]; other site 862908004586 active site 862908004587 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 862908004588 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 862908004589 substrate-cofactor binding pocket; other site 862908004590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908004591 catalytic residue [active] 862908004592 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 6.9e-25 862908004593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004594 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 862908004595 1 probable transmembrane helix predicted for BMS1210 by TMHMM2.0 at aa 5-24 862908004596 PilZ domain; Region: PilZ; pfam07238 862908004597 aminopeptidase N; Provisional; Region: pepN; PRK14015 862908004598 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 862908004599 active site 862908004600 Zn binding site [ion binding]; other site 862908004601 HMMPfam hit to PF01433, Peptidase M1, membrane alanine aminopeptidase, score 5.9e-56 862908004602 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908004603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 862908004604 membrane-bound complex binding site; other site 862908004605 hinge residues; other site 862908004606 Signal peptide predicted for BMS1213 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 20 and 21 862908004607 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908004608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908004609 substrate binding pocket [chemical binding]; other site 862908004610 membrane-bound complex binding site; other site 862908004611 hinge residues; other site 862908004612 Signal peptide predicted for BMS1214 by SignalP 2.0 HMM (Signal peptide probability 0.655) with cleavage site probability 0.439 between residues 17 and 18 862908004613 Signal peptide predicted for BMS1216 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 862908004614 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 862908004615 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 862908004616 4 probable transmembrane helices predicted for BMS1217 by TMHMM2.0 at aa 21-40, 75-97, 110-132 and 191-213 862908004617 Signal peptide predicted for BMS1218 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.977 between residues 21 and 22 862908004618 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004619 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 862908004620 PS00190 Cytochrome c family heme-binding site signature. 862908004621 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 2.9e-10 862908004622 PS00190 Cytochrome c family heme-binding site signature. 862908004623 1 probable transmembrane helix predicted for BMS1219 by TMHMM2.0 at aa 20-37 862908004624 Signal peptide predicted for BMS1219 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.972 between residues 35 and 36 862908004625 Imelysin; Region: Peptidase_M75; cl09159 862908004626 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 862908004627 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 862908004628 Signal peptide predicted for BMS1221 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.934 between residues 25 and 26 862908004629 1 probable transmembrane helix predicted for BMS1221 by TMHMM2.0 at aa 5-27 862908004630 HMMPfam hit to PF06537, Protein of unknown function DUF1111, score 1.8e-164 862908004631 PS00190 Cytochrome c family heme-binding site signature. 862908004632 PS00190 Cytochrome c family heme-binding site signature. 862908004633 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 862908004634 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 862908004635 active site 862908004636 intersubunit interface [polypeptide binding]; other site 862908004637 zinc binding site [ion binding]; other site 862908004638 Na+ binding site [ion binding]; other site 862908004639 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 1e-116 862908004640 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 862908004641 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862908004642 tetramer interface [polypeptide binding]; other site 862908004643 TPP-binding site [chemical binding]; other site 862908004644 heterodimer interface [polypeptide binding]; other site 862908004645 phosphorylation loop region [posttranslational modification] 862908004646 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862908004647 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 862908004648 PYR/PP interface [polypeptide binding]; other site 862908004649 dimer interface [polypeptide binding]; other site 862908004650 TPP binding site [chemical binding]; other site 862908004651 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862908004652 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 7.2e-38 862908004653 HMMPfam hit to PF02779, Transketolase, central region, score 8.9e-28 862908004654 HMMPfam hit to PF02780, Transketolase, C terminal, score 1.3e-52 862908004655 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862908004656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908004657 dimer interface [polypeptide binding]; other site 862908004658 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862908004659 putative CheW interface [polypeptide binding]; other site 862908004660 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2e-38 862908004661 Signal peptide predicted for BMS1224 by SignalP 2.0 HMM (Signal peptide probability 0.782) with cleavage site probability 0.456 between residues 28 and 29 862908004662 1 probable transmembrane helix predicted for BMS1224 by TMHMM2.0 at aa 9-28 862908004663 CHASE2 domain; Region: CHASE2; pfam05226 862908004664 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 862908004665 cyclase homology domain; Region: CHD; cd07302 862908004666 nucleotidyl binding site; other site 862908004667 metal binding site [ion binding]; metal-binding site 862908004668 dimer interface [polypeptide binding]; other site 862908004669 HMMPfam hit to PF00211, Guanylate cyclase, score 4.9e-17 862908004670 4 probable transmembrane helices predicted for BMS1225 by TMHMM2.0 at aa 5-27, 357-376, 381-403 and 410-432 862908004671 HMMPfam hit to PF05226, CHASE2, score 1.1e-08 862908004672 Signal peptide predicted for BMS1225 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.381 between residues 27 and 28 862908004673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908004674 binding surface 862908004675 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908004676 TPR motif; other site 862908004677 HMMPfam hit to PF07719, , score 0.012; PF07719, Tetratricopeptide repeat 862908004678 Signal peptide predicted for BMS1226 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.989 between residues 20 and 21 862908004679 FecR protein; Region: FecR; pfam04773 862908004680 Signal peptide predicted for BMS1227 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 862908004681 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 862908004682 ArsC family; Region: ArsC; pfam03960 862908004683 catalytic residues [active] 862908004684 HMMPfam hit to PF03960, Arsenate reductase and related, score 4.1e-29 862908004685 Signal peptide predicted for BMS1230 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.527 between residues 19 and 20 862908004686 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 862908004687 Signal peptide predicted for BMS1231 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.604 between residues 17 and 18 862908004688 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 862908004689 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 862908004690 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 5.1e-95 862908004691 Signal peptide predicted for BMS1233 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.889 between residues 18 and 19 862908004692 Signal peptide predicted for BMS1234 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.978 between residues 16 and 17 862908004693 Signal peptide predicted for BMS1235 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.625 between residues 23 and 24 862908004694 Signal peptide predicted for BMS1236 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.511 between residues 28 and 29 862908004695 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004696 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 862908004697 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 862908004698 HMMPfam hit to PF01106, Nitrogen-fixing NifU, C-terminal, score 5.2e-16 862908004699 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 862908004700 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 862908004701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908004702 catalytic residue [active] 862908004703 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.1e-14 862908004704 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 862908004705 FeS assembly protein SufD; Region: sufD; TIGR01981 862908004706 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 862908004707 HMMPfam hit to PF01458, SufBD, score 3.3e-41 862908004708 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 862908004709 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 862908004710 Walker A/P-loop; other site 862908004711 ATP binding site [chemical binding]; other site 862908004712 Q-loop/lid; other site 862908004713 ABC transporter signature motif; other site 862908004714 Walker B; other site 862908004715 D-loop; other site 862908004716 H-loop/switch region; other site 862908004717 HMMPfam hit to PF00005, ABC transporter, score 1e-31 862908004718 PS00211 ABC transporters family signature. 862908004719 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004720 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 862908004721 putative ABC transporter; Region: ycf24; CHL00085 862908004722 HMMPfam hit to PF01458, SufBD, score 2.6e-134 862908004723 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 862908004724 Transcriptional regulator; Region: Rrf2; pfam02082 862908004725 Transcriptional regulator; Region: Rrf2; cl17282 862908004726 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 862908004727 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 862908004728 HMMPfam hit to PF01598, Sterol desaturase, score 2e-05 862908004729 3 probable transmembrane helices predicted for BMS1245 by TMHMM2.0 at aa 5-22, 42-64 and 77-99 862908004730 Rhomboid family; Region: Rhomboid; pfam01694 862908004731 6 probable transmembrane helices predicted for BMS1248 by TMHMM2.0 at aa 72-94, 125-147, 160-182, 187-204, 224-257 and 272-291 862908004732 HMMPfam hit to PF01694, Rhomboid-like protein, score 6e-26 862908004733 Signal peptide predicted for BMS1249 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 862908004734 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004735 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004736 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 862908004737 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 862908004738 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 862908004739 active site 862908004740 HIGH motif; other site 862908004741 KMSK motif region; other site 862908004742 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862908004743 tRNA binding surface [nucleotide binding]; other site 862908004744 anticodon binding site; other site 862908004745 HMMPfam hit to PF05746, Arginyl tRNA synthetase anticodon binding, score 6.5e-38 862908004746 HMMPfam hit to PF00750, Arginyl-tRNA synthetase, class Ic, score 1.4e-22 862908004747 HMMPfam hit to PF03485, Arginyl tRNA synthetase, N-terminal, score 4.2e-18 862908004748 Signal peptide predicted for BMS1251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.916 between residues 33 and 34 862908004749 1 probable transmembrane helix predicted for BMS1251 by TMHMM2.0 at aa 13-35 862908004750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908004751 Coenzyme A binding pocket [chemical binding]; other site 862908004752 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862908004753 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.3e-09 862908004754 Signal peptide predicted for BMS1253 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.922 between residues 20 and 21 862908004755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908004756 TopoisomeraseII; Region: TOP2c; smart00433 862908004757 ATP binding site [chemical binding]; other site 862908004758 Mg2+ binding site [ion binding]; other site 862908004759 G-X-G motif; other site 862908004760 DNA gyrase B; Region: DNA_gyraseB; pfam00204 862908004761 ATP binding site [chemical binding]; other site 862908004762 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 862908004763 active site 862908004764 putative metal-binding site [ion binding]; other site 862908004765 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862908004766 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 5.2e-08 862908004767 HMMPfam hit to PF00204, DNA topoisomerase II, score 3.2e-09 862908004768 PS00177 DNA topoisomerase II signature. 862908004769 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 862908004770 CAP-like domain; other site 862908004771 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 862908004772 active site 862908004773 primary dimer interface [polypeptide binding]; other site 862908004774 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 3.6e-23 862908004775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908004776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908004777 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862908004778 IHF - DNA interface [nucleotide binding]; other site 862908004779 IHF dimer interface [polypeptide binding]; other site 862908004780 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 5.4e-40 862908004781 PS00045 Bacterial histone-like DNA-binding proteins signature. 862908004782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862908004783 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862908004784 DNA binding residues [nucleotide binding] 862908004785 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 862908004786 substrate binding pocket [chemical binding]; other site 862908004787 substrate-Mg2+ binding site; other site 862908004788 aspartate-rich region 1; other site 862908004789 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 862908004790 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004791 HMMPfam hit to PF00348, Polyprenyl synthetase, score 4e-30 862908004792 PS00723 Polyprenyl synthetases signature 1. 862908004793 1 probable transmembrane helix predicted for BMS1260 by TMHMM2.0 at aa 26-48 862908004794 1 probable transmembrane helix predicted for BMS1261 by TMHMM2.0 at aa 48-70 862908004795 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 862908004796 Cell division protein FtsA; Region: FtsA; pfam14450 862908004797 1 probable transmembrane helix predicted for BMS1262 by TMHMM2.0 at aa 368-387 862908004798 Signal peptide predicted for BMS1263 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.745 between residues 29 and 30 862908004799 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 862908004800 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 862908004801 Signal peptide predicted for BMS1264 by SignalP 2.0 HMM (Signal peptide probability 0.725) with cleavage site probability 0.258 between residues 43 and 44 862908004802 PS00409 Prokaryotic N-terminal methylation site. 862908004803 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 862908004804 Signal peptide predicted for BMS1265 by SignalP 2.0 HMM (Signal peptide probability 0.788) with cleavage site probability 0.671 between residues 36 and 37 862908004805 1 probable transmembrane helix predicted for BMS1266 by TMHMM2.0 at aa 12-34 862908004806 PS00409 Prokaryotic N-terminal methylation site. 862908004807 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 862908004808 Signal peptide predicted for BMS1267 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.344 between residues 41 and 42 862908004809 1 probable transmembrane helix predicted for BMS1267 by TMHMM2.0 at aa 13-35 862908004810 PS00409 Prokaryotic N-terminal methylation site. 862908004811 type II secretion system protein F; Region: GspF; TIGR02120 862908004812 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908004813 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908004814 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 3.2e-22 862908004815 3 probable transmembrane helices predicted for BMS1268 by TMHMM2.0 at aa 171-193, 214-236 and 373-395 862908004816 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 4.1e-21 862908004817 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 862908004818 type II secretion system protein E; Region: type_II_gspE; TIGR02533 862908004819 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 862908004820 Walker A motif; other site 862908004821 ATP binding site [chemical binding]; other site 862908004822 Walker B motif; other site 862908004823 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 5.9e-113 862908004824 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004825 HMMPfam hit to PF05157, General secretory system II, protein E, N-terminal, score 1.9e-08 862908004826 type II secretion system protein D; Region: type_II_gspD; TIGR02517 862908004827 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 862908004828 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 862908004829 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 862908004830 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 862908004831 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 2.9e-52 862908004832 PS00875 Bacterial type II secretion system protein D signature. 862908004833 HMMPfam hit to PF03958, NolW-like, score 7.2e-14 862908004834 HMMPfam hit to PF03958, NolW-like, score 5.7e-06 862908004835 HMMPfam hit to PF03958, NolW-like, score 4.1e-07 862908004836 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862908004837 protein binding site [polypeptide binding]; other site 862908004838 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 0.078 862908004839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908004840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908004841 active site 862908004842 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 3e-20 862908004843 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 8.4e-43 862908004844 PS00072 Acyl-CoA dehydrogenases signature 1. 862908004845 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 2e-57 862908004846 Family description; Region: VCBS; pfam13517 862908004847 Family description; Region: VCBS; pfam13517 862908004848 Family description; Region: VCBS; pfam13517 862908004849 Family description; Region: VCBS; pfam13517 862908004850 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 862908004851 Signal peptide predicted for BMS1273 by SignalP 2.0 HMM (Signal peptide probability 0.612) with cleavage site probability 0.388 between residues 20 and 21 862908004852 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004853 HMMPfam hit to PF01839, Integrins alpha chain, score 0.038 862908004854 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 862908004855 HMMPfam hit to PF01258, Zn-finger, prokaryotic DksA/TraR C4 type, score 2.3e-10 862908004856 Signal peptide predicted for BMS1277 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19 862908004857 heat shock protein 90; Provisional; Region: PRK05218 862908004858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908004859 ATP binding site [chemical binding]; other site 862908004860 Mg2+ binding site [ion binding]; other site 862908004861 G-X-G motif; other site 862908004862 HMMPfam hit to PF00183, Heat shock protein Hsp90, score 4.2e-11 862908004863 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.00022 862908004864 Asparaginase; Region: Asparaginase; pfam00710 862908004865 active site 862908004866 5 probable transmembrane helices predicted for BMS1280 by TMHMM2.0 at aa 21-36, 51-73, 93-115, 142-164 and 176-198 862908004867 Signal peptide predicted for BMS1281 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.767 between residues 23 and 24 862908004868 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004869 Signal peptide predicted for BMS1282 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.944 between residues 14 and 15 862908004870 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 862908004871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862908004872 dimer interface [polypeptide binding]; other site 862908004873 substrate binding site [chemical binding]; other site 862908004874 metal binding site [ion binding]; metal-binding site 862908004875 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 2.9e-15 862908004876 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 862908004877 Signal peptide predicted for BMS1284 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.473 between residues 34 and 35 862908004878 6 probable transmembrane helices predicted for BMS1284 by TMHMM2.0 at aa 20-42, 62-84, 96-118, 123-145, 152-174 and 184-203 862908004879 HMMPfam hit to PF01694, Rhomboid-like protein, score 2e-08 862908004880 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862908004881 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.8e-08 862908004882 1 probable transmembrane helix predicted for BMS1286 by TMHMM2.0 at aa 10-29 862908004883 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862908004884 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862908004885 Signal peptide predicted for BMS1287 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.622 between residues 24 and 25 862908004886 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 0.0004 862908004887 PS00134 Serine proteases, trypsin family, histidine active site. 862908004888 PS00673 Serine proteases, V8 family, serine active site. 862908004889 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004890 Signal peptide predicted for BMS1289 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.491 between residues 21 and 22 862908004891 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908004892 PLD-like domain; Region: PLDc_2; pfam13091 862908004893 putative active site [active] 862908004894 catalytic site [active] 862908004895 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908004896 PLD-like domain; Region: PLDc_2; pfam13091 862908004897 putative active site [active] 862908004898 catalytic site [active] 862908004899 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.0071 862908004900 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.025 862908004901 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862908004902 Signal peptide predicted for BMS1291 by SignalP 2.0 HMM (Signal peptide probability 0.923) with cleavage site probability 0.888 between residues 18 and 19 862908004903 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004904 Signal peptide predicted for BMS1292 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.961 between residues 18 and 19 862908004905 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 862908004906 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 862908004907 hexamer interface [polypeptide binding]; other site 862908004908 ligand binding site [chemical binding]; other site 862908004909 putative active site [active] 862908004910 NAD(P) binding site [chemical binding]; other site 862908004911 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal, score 2.1e-94 862908004912 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal, score 5e-70 862908004913 putative hydrolase; Provisional; Region: PRK02113 862908004914 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 862908004915 HMMPfam hit to PF00753, Beta-lactamase-like, score 4.2e-05 862908004916 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862908004917 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862908004918 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862908004919 Signal peptide predicted for BMS1295 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.846 between residues 22 and 23 862908004920 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908004921 HMMPfam hit to PF00675, Insulinase-like, score 1.5e-22 862908004922 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.9e-22 862908004923 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862908004924 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862908004925 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862908004926 Signal peptide predicted for BMS1296 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.514 between residues 23 and 24 862908004927 HMMPfam hit to PF00675, Insulinase-like, score 0.0002 862908004928 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.3e-12 862908004929 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 862908004930 HMMPfam hit to PF04519, Protein of unknown function DUF583, score 7.1e-19 862908004931 1 probable transmembrane helix predicted for BMS1298 by TMHMM2.0 at aa 32-54 862908004932 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862908004933 Signal peptide predicted for BMS1299 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.992 between residues 20 and 21 862908004934 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 862908004935 Transmembrane protein; Region: Macoilin; pfam09726 862908004936 PS00017 ATP/GTP-binding site motif A (P-loop). 862908004937 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862908004938 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862908004939 metal binding site [ion binding]; metal-binding site 862908004940 active site 862908004941 I-site; other site 862908004942 HMMPfam hit to PF00990, GGDEF, score 2.9e-47 862908004943 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 862908004944 putative active site [active] 862908004945 putative metal binding site [ion binding]; other site 862908004946 amino acid transporter; Region: 2A0306; TIGR00909 862908004947 Spore germination protein; Region: Spore_permease; cl17796 862908004948 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862908004949 Ligand Binding Site [chemical binding]; other site 862908004950 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.9e-36 862908004951 11 probable transmembrane helices predicted for BMS1303 by TMHMM2.0 at aa 61-83, 87-109, 145-167, 172-191, 198-220, 235-257, 270-292, 316-338, 365-384, 394-413 and 434-468 862908004952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004953 active site 862908004954 phosphorylation site [posttranslational modification] 862908004955 dimerization interface [polypeptide binding]; other site 862908004956 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 862908004957 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862908004958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908004959 HMMPfam hit to PF00072, Response regulator receiver, score 3.3e-06 862908004960 HMMPfam hit to PF00023, Ankyrin, score 1.3e-06 862908004961 HMMPfam hit to PF00023, Ankyrin, score 3.9e-05 862908004962 HMMPfam hit to PF00023, Ankyrin, score 0.58 862908004963 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908004964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004965 active site 862908004966 phosphorylation site [posttranslational modification] 862908004967 intermolecular recognition site; other site 862908004968 dimerization interface [polypeptide binding]; other site 862908004969 HMMPfam hit to PF00072, Response regulator receiver, score 3.9e-05 862908004970 Response regulator receiver domain; Region: Response_reg; pfam00072 862908004971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004972 active site 862908004973 phosphorylation site [posttranslational modification] 862908004974 intermolecular recognition site; other site 862908004975 dimerization interface [polypeptide binding]; other site 862908004976 HMMPfam hit to PF00072, Response regulator receiver, score 2.1e-17 862908004977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004978 Response regulator receiver domain; Region: Response_reg; pfam00072 862908004979 active site 862908004980 phosphorylation site [posttranslational modification] 862908004981 intermolecular recognition site; other site 862908004982 dimerization interface [polypeptide binding]; other site 862908004983 HMMPfam hit to PF00072, Response regulator receiver, score 4.6e-13 862908004984 Hpt domain; Region: Hpt; pfam01627 862908004985 HMMPfam hit to PF01627, Hpt, score 4.2e-05 862908004986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862908004987 intermolecular recognition site; other site 862908004988 Response regulator receiver domain; Region: Response_reg; pfam00072 862908004989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908004990 active site 862908004991 phosphorylation site [posttranslational modification] 862908004992 intermolecular recognition site; other site 862908004993 dimerization interface [polypeptide binding]; other site 862908004994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908004995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908004996 dimer interface [polypeptide binding]; other site 862908004997 phosphorylation site [posttranslational modification] 862908004998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908004999 ATP binding site [chemical binding]; other site 862908005000 Mg2+ binding site [ion binding]; other site 862908005001 G-X-G motif; other site 862908005002 HMMPfam hit to PF00072, Response regulator receiver, score 2.8e-21 862908005003 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.3e-15 862908005004 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.2e-33 862908005005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908005006 active site 862908005007 phosphorylation site [posttranslational modification] 862908005008 intermolecular recognition site; other site 862908005009 dimerization interface [polypeptide binding]; other site 862908005010 HMMPfam hit to PF00072, Response regulator receiver, score 4e-13 862908005011 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 862908005012 NAD synthetase; Provisional; Region: PRK13981 862908005013 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 862908005014 multimer interface [polypeptide binding]; other site 862908005015 active site 862908005016 catalytic triad [active] 862908005017 protein interface 1 [polypeptide binding]; other site 862908005018 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 862908005019 homodimer interface [polypeptide binding]; other site 862908005020 NAD binding pocket [chemical binding]; other site 862908005021 ATP binding pocket [chemical binding]; other site 862908005022 Mg binding site [ion binding]; other site 862908005023 active-site loop [active] 862908005024 HMMPfam hit to PF02540, NAD+ synthase, score 6.3e-59 862908005025 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 3.7e-05 862908005026 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 862908005027 Glucose inhibited division protein A; Region: GIDA; pfam01134 862908005028 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 5.4e-70 862908005029 EamA-like transporter family; Region: EamA; cl17759 862908005030 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862908005031 8 probable transmembrane helices predicted for BMS1314 by TMHMM2.0 at aa 3-25, 29-51, 64-83, 93-115, 122-144, 159-180, 193-210 and 220-242 862908005032 HMMPfam hit to PF00892, Protein of unknown function DUF6, score 1.2e-09 862908005033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908005034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908005035 NAD(P) binding site [chemical binding]; other site 862908005036 active site 862908005037 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.3e-31 862908005038 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908005039 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908005040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908005041 substrate binding pocket [chemical binding]; other site 862908005042 membrane-bound complex binding site; other site 862908005043 hinge residues; other site 862908005044 Signal peptide predicted for BMS1317 by SignalP 2.0 HMM (Signal peptide probability 0.887) with cleavage site probability 0.875 between residues 32 and 33 862908005045 1 probable transmembrane helix predicted for BMS1317 by TMHMM2.0 at aa 13-35 862908005046 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 862908005047 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 862908005048 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 0.0078 862908005049 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 862908005050 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862908005051 DNA binding residues [nucleotide binding] 862908005052 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 7e-07 862908005053 Signal peptide predicted for BMS1321 by SignalP 2.0 HMM (Signal peptide probability 0.664) with cleavage site probability 0.617 between residues 21 and 22 862908005054 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005055 DTW domain; Region: DTW; cl01221 862908005056 HMMPfam hit to PF03942, DTW, score 1.8e-23 862908005057 Signal peptide predicted for BMS1324 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.516 between residues 23 and 24 862908005058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005059 Endonuclease I; Region: Endonuclease_1; pfam04231 862908005060 HMMPfam hit to PF04231, Endonuclease I, score 5.1e-16 862908005061 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 862908005062 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862908005063 dimer interface [polypeptide binding]; other site 862908005064 active site 862908005065 CoA binding pocket [chemical binding]; other site 862908005066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862908005067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862908005068 active site 862908005069 catalytic tetrad [active] 862908005070 HMMPfam hit to PF00248, Aldo/keto reductase, score 5.3e-39 862908005071 4 probable transmembrane helices predicted for BMS1330 by TMHMM2.0 at aa 47-69, 74-96, 162-184 and 199-221 862908005072 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 862908005073 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 862908005074 catalytic triad [active] 862908005075 putative active site [active] 862908005076 Signal peptide predicted for BMS1331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 18 and 19 862908005077 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 5.1e-66 862908005078 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908005079 PS00137 Serine proteases, subtilase family, histidine active site. 862908005080 PS00138 Serine proteases, subtilase family, serine active site. 862908005081 1 probable transmembrane helix predicted for BMS1332 by TMHMM2.0 at aa 2-24 862908005082 Signal peptide predicted for BMS1332 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.617 between residues 20 and 21 862908005083 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 862908005084 apolar tunnel; other site 862908005085 heme binding site [chemical binding]; other site 862908005086 dimerization interface [polypeptide binding]; other site 862908005087 HMMPfam hit to PF01152, Protozoan/cyanobacterial globin, score 1.3e-36 862908005088 Domain of unknown function (DUF309); Region: DUF309; pfam03745 862908005089 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862908005090 active site 862908005091 substrate binding site [chemical binding]; other site 862908005092 catalytic site [active] 862908005093 HMMPfam hit to PF00929, Exonuclease, score 1.2e-05 862908005094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908005095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908005096 dimer interface [polypeptide binding]; other site 862908005097 phosphorylation site [posttranslational modification] 862908005098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908005099 ATP binding site [chemical binding]; other site 862908005100 Mg2+ binding site [ion binding]; other site 862908005101 G-X-G motif; other site 862908005102 1 probable transmembrane helix predicted for BMS1337 by TMHMM2.0 at aa 257-276 862908005103 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.9e-07 862908005104 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.6e-15 862908005105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908005106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908005107 active site 862908005108 phosphorylation site [posttranslational modification] 862908005109 intermolecular recognition site; other site 862908005110 dimerization interface [polypeptide binding]; other site 862908005111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908005112 DNA binding site [nucleotide binding] 862908005113 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-29 862908005114 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-23 862908005115 1 probable transmembrane helix predicted for BMS1339 by TMHMM2.0 at aa 4-21 862908005116 2 probable transmembrane helices predicted for BMS1340 by TMHMM2.0 at aa 33-55 and 67-89 862908005117 Endonuclease I; Region: Endonuclease_1; cl01003 862908005118 HMMPfam hit to PF04231, Endonuclease I, score 2.4e-14 862908005119 Signal peptide predicted for BMS1341 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.494 between residues 22 and 23 862908005120 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005121 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 862908005122 putative efflux protein, MATE family; Region: matE; TIGR00797 862908005123 cation binding site [ion binding]; other site 862908005124 12 probable transmembrane helices predicted for BMS1342 by TMHMM2.0 at aa 16-38, 53-75, 96-118, 128-147, 159-181, 191-213, 234-256, 271-293, 306-328, 348-370, 382-401 and 411-433 862908005125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005126 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 2.6e-34 862908005127 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 862908005128 Protein export membrane protein; Region: SecD_SecF; cl14618 862908005129 12 probable transmembrane helices predicted for BMS1343 by TMHMM2.0 at aa 12-34, 223-245, 250-272, 277-299, 320-342, 352-374, 404-423, 601-623, 630-652, 662-684, 704-726 and 736-758 862908005130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005131 PilZ domain; Region: PilZ; pfam07238 862908005132 4 probable transmembrane helices predicted for BMS1344 by TMHMM2.0 at aa 7-29, 39-61, 68-88 and 93-115 862908005133 Signal peptide predicted for BMS1344 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.631 between residues 21 and 22 862908005134 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862908005135 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908005136 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908005137 catalytic residue [active] 862908005138 Signal peptide predicted for BMS1345 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.749 between residues 29 and 30 862908005139 MoxR-like ATPases [General function prediction only]; Region: COG0714 862908005140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908005141 Walker A motif; other site 862908005142 ATP binding site [chemical binding]; other site 862908005143 Walker B motif; other site 862908005144 arginine finger; other site 862908005145 HMMPfam hit to PF07726, , score 1e-70 862908005146 Protein of unknown function DUF58; Region: DUF58; pfam01882 862908005147 Signal peptide predicted for BMS1348 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.597 between residues 34 and 35 862908005148 2 probable transmembrane helices predicted for BMS1348 by TMHMM2.0 at aa 13-35 and 39-61 862908005149 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 4.6e-07 862908005150 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 862908005151 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 862908005152 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862908005153 7 probable transmembrane helices predicted for BMS1349 by TMHMM2.0 at aa 15-46, 53-70, 75-97, 104-121, 126-148, 161-180 and 546-563 862908005154 HMMPfam hit to PF01841, Transglutaminase-like, score 5.6e-13 862908005155 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 862908005156 active site 862908005157 catalytic triad [active] 862908005158 oxyanion hole [active] 862908005159 switch loop; other site 862908005160 Signal peptide predicted for BMS1350 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.958 between residues 18 and 19 862908005161 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 2.5e-22 862908005162 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862908005163 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862908005164 Walker A/P-loop; other site 862908005165 ATP binding site [chemical binding]; other site 862908005166 Q-loop/lid; other site 862908005167 ABC transporter signature motif; other site 862908005168 Walker B; other site 862908005169 D-loop; other site 862908005170 H-loop/switch region; other site 862908005171 HMMPfam hit to PF00005, ABC transporter, score 1.2e-53 862908005172 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005173 PS00211 ABC transporters family signature. 862908005174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862908005175 FtsX-like permease family; Region: FtsX; pfam02687 862908005176 Signal peptide predicted for BMS1352 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.442 between residues 42 and 43 862908005177 10 probable transmembrane helices predicted for BMS1352 by TMHMM2.0 at aa 13-35, 249-271, 291-313, 343-365, 386-408, 412-431, 458-480, 707-729, 761-783 and 793-815 862908005178 HMMPfam hit to PF02687, Protein of unknown function DUF214, score 2e-05 862908005179 HMMPfam hit to PF02687, Protein of unknown function DUF214, score 2.8e-15 862908005180 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862908005181 metal ion-dependent adhesion site (MIDAS); other site 862908005182 1 probable transmembrane helix predicted for BMS1353 by TMHMM2.0 at aa 7-29 862908005183 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862908005184 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 0.00024 862908005185 4 probable transmembrane helices predicted for BMS1354 by TMHMM2.0 at aa 13-32, 47-66, 163-185 and 200-222 862908005186 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862908005187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908005188 ATP binding site [chemical binding]; other site 862908005189 putative Mg++ binding site [ion binding]; other site 862908005190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908005191 nucleotide binding region [chemical binding]; other site 862908005192 ATP-binding site [chemical binding]; other site 862908005193 HMMPfam hit to PF00271, Helicase, C-terminal, score 1.4e-19 862908005194 HMMPfam hit to PF00176, SNF2-related, score 4.9e-77 862908005195 HMMPfam hit to PF04434, SWIM Zn-finger, score 0.02 862908005196 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 862908005197 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.2e-21 862908005198 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862908005199 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 862908005200 Walker A/P-loop; other site 862908005201 ATP binding site [chemical binding]; other site 862908005202 Q-loop/lid; other site 862908005203 ABC transporter signature motif; other site 862908005204 Walker B; other site 862908005205 D-loop; other site 862908005206 H-loop/switch region; other site 862908005207 HMMPfam hit to PF00005, ABC transporter, score 3.8e-41 862908005208 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005209 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908005210 6 probable transmembrane helices predicted for BMS1358 by TMHMM2.0 at aa 22-44, 59-81, 110-132, 147-169, 176-198 and 242-264 862908005211 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 862908005212 7 probable transmembrane helices predicted for BMS1360 by TMHMM2.0 at aa 13-35, 40-59, 79-96, 100-117, 129-151, 155-174 and 187-209 862908005213 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 862908005214 HMMPfam hit to PF06629, MltA-interacting MipA, score 1.3e-07 862908005215 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862908005216 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862908005217 active site 862908005218 catalytic site [active] 862908005219 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 1.2e-36 862908005220 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 862908005221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908005222 dimer interface [polypeptide binding]; other site 862908005223 phosphorylation site [posttranslational modification] 862908005224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908005225 ATP binding site [chemical binding]; other site 862908005226 Mg2+ binding site [ion binding]; other site 862908005227 G-X-G motif; other site 862908005228 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.2e-23 862908005229 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.8e-09 862908005230 6 probable transmembrane helices predicted for BMS1365 by TMHMM2.0 at aa 20-42, 47-65, 70-87, 92-114, 121-140 and 155-172 862908005231 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908005232 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 862908005233 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862908005234 dimer interface [polypeptide binding]; other site 862908005235 active site 862908005236 HMMPfam hit to PF00108, Thiolase, score 6.8e-48 862908005237 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908005238 HMMPfam hit to PF02803, Thiolase, score 2e-41 862908005239 PS00737 Thiolases signature 2. 862908005240 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862908005241 FOG: CBS domain [General function prediction only]; Region: COG0517 862908005242 FOG: CBS domain [General function prediction only]; Region: COG0517 862908005243 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 862908005244 HMMPfam hit to PF00571, CBS, score 0.0015 862908005245 HMMPfam hit to PF00571, CBS, score 0.51 862908005246 HMMPfam hit to PF00571, CBS, score 3.6e-07 862908005247 HMMPfam hit to PF00571, CBS, score 0.054 862908005248 2 probable transmembrane helices predicted for BMS1369 by TMHMM2.0 at aa 13-35 and 50-67 862908005249 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 862908005250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908005251 ATP binding site [chemical binding]; other site 862908005252 putative Mg++ binding site [ion binding]; other site 862908005253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908005254 nucleotide binding region [chemical binding]; other site 862908005255 ATP-binding site [chemical binding]; other site 862908005256 RQC domain; Region: RQC; cl09632 862908005257 HRDC domain; Region: HRDC; pfam00570 862908005258 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 2.1e-28 862908005259 HMMPfam hit to PF00271, Helicase, C-terminal, score 2.3e-27 862908005260 HMMPfam hit to PF00570, HRDC, score 3.8e-15 862908005261 1 probable transmembrane helix predicted for BMS1371 by TMHMM2.0 at aa 7-29 862908005262 NAD-dependent deacetylase; Provisional; Region: PRK00481 862908005263 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 862908005264 NAD+ binding site [chemical binding]; other site 862908005265 substrate binding site [chemical binding]; other site 862908005266 Zn binding site [ion binding]; other site 862908005267 HMMPfam hit to PF02146, Silent information regulator protein Sir2, score 3.6e-58 862908005268 3 probable transmembrane helices predicted for BMS1374 by TMHMM2.0 at aa 36-58, 68-87 and 94-116 862908005269 Signal peptide predicted for BMS1375 by SignalP 2.0 HMM (Signal peptide probability 0.932) with cleavage site probability 0.440 between residues 22 and 23 862908005270 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 862908005272 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 862908005273 DnaA box-binding interface [nucleotide binding]; other site 862908005274 HMMPfam hit to PF00308, Bacterial chromosomal replication initiator protein, DnaA, score 2e-15 862908005275 PS00041 Bacterial regulatory proteins, araC family signature. 862908005276 PS01008 DnaA protein signature. 862908005277 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908005278 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908005279 phosphopeptide binding site; other site 862908005280 HMMPfam hit to PF00498, Forkhead-associated, score 8.9e-12 862908005281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908005282 binding surface 862908005283 TPR motif; other site 862908005284 HMMPfam hit to PF07719, , score 0.00013; PF07719, Tetratricopeptide repeat 862908005285 Signal peptide predicted for BMS1378 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.560 between residues 19 and 20 862908005286 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005287 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908005288 HMMPfam hit to PF07719, , score 0.4; PF07719, Tetratricopeptide repeat 862908005289 HMMPfam hit to PF07719, , score 1; PF07719, Tetratricopeptide repeat 862908005290 Signal peptide predicted for BMS1379 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.974 between residues 24 and 25 862908005291 1 probable transmembrane helix predicted for BMS1380 by TMHMM2.0 at aa 20-37 862908005292 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 862908005293 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 0.00013 862908005294 1 probable transmembrane helix predicted for BMS1381 by TMHMM2.0 at aa 13-35 862908005295 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 862908005296 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 1.4e-10 862908005297 3 probable transmembrane helices predicted for BMS1382 by TMHMM2.0 at aa 20-42, 125-147 and 172-194 862908005298 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908005299 Signal peptide predicted for BMS1383 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.947 between residues 15 and 16 862908005300 HMMPfam hit to PF07719, , score 0.11; PF07719, Tetratricopeptide repeat 862908005301 Signal peptide predicted for BMS1384 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.791 between residues 17 and 18 862908005302 Signal peptide predicted for BMS1385 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28 862908005303 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 862908005304 metal ion-dependent adhesion site (MIDAS); other site 862908005305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862908005306 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 862908005307 5 probable transmembrane helices predicted for BMS1389 by TMHMM2.0 at aa 47-69, 109-131, 152-174, 179-201 and 206-228 862908005308 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 2.6e-08 862908005309 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862908005310 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 862908005311 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862908005312 FOG: CBS domain [General function prediction only]; Region: COG0517 862908005313 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 862908005314 HMMPfam hit to PF00571, CBS, score 6.1e-08 862908005315 HMMPfam hit to PF00571, CBS, score 3.9e-06 862908005316 10 probable transmembrane helices predicted for BMS1390 by TMHMM2.0 at aa 7-29, 60-82, 102-121, 131-153, 166-188, 208-230, 287-306, 316-338, 350-372 and 382-404 862908005317 1 probable transmembrane helix predicted for BMS1391 by TMHMM2.0 at aa 5-24 862908005318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908005319 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 862908005320 NAD(P) binding site [chemical binding]; other site 862908005321 active site 862908005322 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862908005323 catalytic residues [active] 862908005324 1 probable transmembrane helix predicted for BMS1394 by TMHMM2.0 at aa 121-139 862908005325 HMMPfam hit to PF00085, Thioredoxin-related, score 3.3e-09 862908005326 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862908005327 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862908005328 active site 862908005329 catalytic tetrad [active] 862908005330 HMMPfam hit to PF00248, Aldo/keto reductase, score 1.6e-56 862908005331 Family description; Region: DsbD_2; pfam13386 862908005332 6 probable transmembrane helices predicted for BMS1397 by TMHMM2.0 at aa 20-42, 55-74, 78-100, 138-160, 170-192 and 205-227 862908005333 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862908005334 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 862908005335 5 probable transmembrane helices predicted for BMS1398 by TMHMM2.0 at aa 41-58, 85-107, 161-180, 195-214 and 328-350 862908005336 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.0029 862908005337 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908005338 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 862908005339 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862908005340 HMMPfam hit to PF00034, Cytochrome c, class I, score 1.2e-06 862908005341 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 862908005342 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 862908005343 Low-spin heme binding site [chemical binding]; other site 862908005344 Putative water exit pathway; other site 862908005345 Binuclear center (active site) [active] 862908005346 Putative proton exit pathway; other site 862908005347 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 862908005348 HMMPfam hit to PF02433, Cytochrome C oxidase, mono-heme subunit/FixO, score 1.9e-86 862908005349 PS00190 Cytochrome c family heme-binding site signature. 862908005350 13 probable transmembrane helices predicted for BMS1401 by TMHMM2.0 at aa 20-42, 62-81, 101-120, 130-152, 164-186, 206-228, 241-259, 274-296, 309-331, 346-368, 381-403, 436-458 and 498-520 862908005351 HMMPfam hit to PF00115, Cytochrome c oxidase, subunit I, score 9.7e-40 862908005352 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 862908005353 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 862908005354 HMMPfam hit to PF03597, Cytochrome oxidase maturation protein cbb3-type, score 4.5e-16 862908005355 Signal peptide predicted for BMS1402 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.495 between residues 25 and 26 862908005356 1 probable transmembrane helix predicted for BMS1402 by TMHMM2.0 at aa 3-25 862908005357 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 862908005358 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862908005359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862908005360 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862908005361 8 probable transmembrane helices predicted for BMS1403 by TMHMM2.0 at aa 187-209, 214-236, 249-271, 276-295, 430-452, 462-484, 745-767 and 771-793 862908005362 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.8e-17 862908005363 PS00154 E1-E2 ATPases phosphorylation site. 862908005364 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 5.7e-38 862908005365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862908005366 Ligand Binding Site [chemical binding]; other site 862908005367 HMMPfam hit to PF00582, UspA, score 5.5e-07 862908005368 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908005369 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908005370 ligand binding site [chemical binding]; other site 862908005371 flexible hinge region; other site 862908005372 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 0.00044 862908005373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908005374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908005375 ligand binding site [chemical binding]; other site 862908005376 flexible hinge region; other site 862908005377 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862908005378 putative switch regulator; other site 862908005379 non-specific DNA interactions [nucleotide binding]; other site 862908005380 DNA binding site [nucleotide binding] 862908005381 sequence specific DNA binding site [nucleotide binding]; other site 862908005382 putative cAMP binding site [chemical binding]; other site 862908005383 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 2.5e-19 862908005384 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862908005385 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862908005386 dimer interface [polypeptide binding]; other site 862908005387 putative functional site; other site 862908005388 putative MPT binding site; other site 862908005389 HMMPfam hit to PF03453, MoeA, N-terminal, domain I and II, score 6.8e-32 862908005390 HMMPfam hit to PF00994, Molybdenum cofactor biosynthesis protein, score 1.9e-30 862908005391 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 862908005392 PS00146 Beta-lactamase class-A active site. 862908005393 1 probable transmembrane helix predicted for BMS1409 by TMHMM2.0 at aa 13-35 862908005394 Signal peptide predicted for BMS1410 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.927 between residues 20 and 21 862908005395 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 862908005396 catalytic triad [active] 862908005397 putative active site [active] 862908005398 Signal peptide predicted for BMS1411 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.989 between residues 25 and 26 862908005399 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 3.3e-46 862908005400 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908005401 PS00137 Serine proteases, subtilase family, histidine active site. 862908005402 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005403 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 862908005404 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 862908005405 Walker A motif; other site 862908005406 hexamer interface [polypeptide binding]; other site 862908005407 ATP binding site [chemical binding]; other site 862908005408 Walker B motif; other site 862908005409 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 1.5e-68 862908005410 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005411 Uncharacterized conserved protein [Function unknown]; Region: COG0327 862908005412 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 862908005413 HMMPfam hit to PF01784, Protein of unknown function DUF34, score 4e-75 862908005414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908005415 binding surface 862908005416 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908005417 TPR motif; other site 862908005418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908005419 TPR repeat; Region: TPR_11; pfam13414 862908005420 binding surface 862908005421 TPR motif; other site 862908005422 HMMPfam hit to PF00515, TPR repeat, score 0.0081; HMMPfam hit to PF07719, , score 0.0013; PF07719, Tetratricopeptide repeat 862908005423 HMMPfam hit to PF07719, , score 0.02; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.0017 862908005424 1 probable transmembrane helix predicted for BMS1418 by TMHMM2.0 at aa 19-41 862908005425 Signal peptide predicted for BMS1419 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.770 between residues 19 and 20 862908005426 Signal peptide predicted for BMS1420 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 862908005427 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862908005428 active site 862908005429 HMMPfam hit to PF03061, Thioesterase superfamily, score 2.4e-09 862908005430 1 probable transmembrane helix predicted for BMS1423 by TMHMM2.0 at aa 53-75 862908005431 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908005432 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908005433 1 probable transmembrane helix predicted for BMS1424 by TMHMM2.0 at aa 28-50 862908005434 Predicted coiled-coil domain-containing protein; Region: TTKRSYEDQ; pfam10212 862908005435 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005436 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005437 Signal peptide predicted for BMS1425 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 31 and 32 862908005438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908005439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908005440 S-adenosylmethionine binding site [chemical binding]; other site 862908005441 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908005442 2 probable transmembrane helices predicted for BMS1427 by TMHMM2.0 at aa 29-48 and 79-101 862908005443 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.5e-64 862908005444 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908005445 Protein export membrane protein; Region: SecD_SecF; cl14618 862908005446 Signal peptide predicted for BMS1428 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.703 between residues 31 and 32 862908005447 HMMPfam hit to PF00873, Acriflavin resistance protein, score 5.2e-63 862908005448 12 probable transmembrane helices predicted for BMS1428 by TMHMM2.0 at aa 13-30, 336-358, 363-385, 392-414, 434-456, 463-485, 527-546, 864-883, 887-909, 916-938, 966-988 and 1000-1022 862908005449 Signal peptide predicted for BMS1429 by SignalP 2.0 HMM (Signal peptide probability 0.937) with cleavage site probability 0.773 between residues 20 and 21 862908005450 carotene isomerase; Region: carot_isom; TIGR02730 862908005451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908005452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908005453 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 862908005454 NAD(P) binding site [chemical binding]; other site 862908005455 active site 862908005456 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.2e-76 862908005457 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 862908005458 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.4e-08 862908005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908005460 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 862908005461 NAD(P) binding site [chemical binding]; other site 862908005462 active site 862908005463 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 862908005464 catalytic triad [active] 862908005465 dimer interface [polypeptide binding]; other site 862908005466 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908005467 HMMPfam hit to PF00462, Glutaredoxin, score 8.2e-10 862908005468 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 1.6e-34 862908005469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 862908005470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908005471 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 862908005472 NAD(P) binding site [chemical binding]; other site 862908005473 active site 862908005474 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/isomerase, score 2.4e-60 862908005475 peptide synthase; Provisional; Region: PRK09274 862908005476 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 862908005477 acyl-activating enzyme (AAE) consensus motif; other site 862908005478 putative AMP binding site [chemical binding]; other site 862908005479 putative active site [active] 862908005480 putative CoA binding site [chemical binding]; other site 862908005481 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1e-47 862908005482 1 probable transmembrane helix predicted for BMS1439 by TMHMM2.0 at aa 65-87 862908005483 haloalkane dehalogenase; Provisional; Region: PRK03592 862908005484 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 6.3e-29 862908005485 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 862908005486 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862908005487 dimer interface [polypeptide binding]; other site 862908005488 active site 862908005489 CoA binding pocket [chemical binding]; other site 862908005490 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 862908005491 1 probable transmembrane helix predicted for BMS1442 by TMHMM2.0 at aa 7-25 862908005492 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862908005493 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 862908005494 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 862908005495 dimer interface [polypeptide binding]; other site 862908005496 active site 862908005497 HMMPfam hit to PF02801, Beta-ketoacyl synthase, score 1.9e-35 862908005498 HMMPfam hit to PF00109, Beta-ketoacyl synthase, score 1.4e-29 862908005499 PS00606 Beta-ketoacyl synthases active site. 862908005500 Predicted transcriptional regulators [Transcription]; Region: COG1510 862908005501 Predicted transcriptional regulator [Transcription]; Region: COG4738 862908005502 Signal peptide predicted for BMS1446 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.988 between residues 20 and 21 862908005503 Signal peptide predicted for BMS1447 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.919 between residues 18 and 19 862908005504 2 probable transmembrane helices predicted for BMS1448 by TMHMM2.0 at aa 12-31 and 179-201 862908005505 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.3e-16 862908005506 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.3e-29 862908005507 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 862908005508 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 862908005509 substrate binding site [chemical binding]; other site 862908005510 dimer interface [polypeptide binding]; other site 862908005511 NADP binding site [chemical binding]; other site 862908005512 catalytic residues [active] 862908005513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862908005514 active site 2 [active] 862908005515 active site 1 [active] 862908005516 HMMPfam hit to PF01575, MaoC-like dehydratase, score 3e-25 862908005517 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 7.7e-16 862908005518 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005519 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 862908005520 ParB-like nuclease domain; Region: ParB; smart00470 862908005521 HMMPfam hit to PF02195, ParB-like nuclease, score 9.1e-12 862908005522 TIGR02147 family protein; Region: Fsuc_second 862908005523 Signal peptide predicted for BMS1454 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 18 and 19 862908005524 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 862908005525 putative ligand binding site [chemical binding]; other site 862908005526 HflK protein; Region: hflK; TIGR01933 862908005527 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 862908005528 HMMPfam hit to PF01145, Band 7 protein, score 2.2e-79 862908005529 1 probable transmembrane helix predicted for BMS1456 by TMHMM2.0 at aa 5-24 862908005530 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 862908005531 putative metal binding site [ion binding]; other site 862908005532 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase, score 5.4e-07 862908005533 Signal peptide predicted for BMS1459 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.983 between residues 24 and 25 862908005534 PS00190 Cytochrome c family heme-binding site signature. 862908005535 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 862908005536 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 862908005537 active site 862908005538 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 862908005539 HMMPfam hit to PF01957, Protein of unknown function DUF107, score 9e-13 862908005540 4 probable transmembrane helices predicted for BMS1460 by TMHMM2.0 at aa 239-261, 271-293, 300-322 and 342-364 862908005541 Signal peptide predicted for BMS1460 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.544 between residues 26 and 27 862908005542 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908005543 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 862908005544 active site 862908005545 HMMPfam hit to PF01979, Amidohydrolase, score 5e-26 862908005546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908005547 non-specific DNA binding site [nucleotide binding]; other site 862908005548 salt bridge; other site 862908005549 sequence-specific DNA binding site [nucleotide binding]; other site 862908005550 HMMPfam hit to PF01381, Helix-turn-helix motif, score 1.1e-06 862908005551 Signal peptide predicted for BMS1463 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 20 and 21 862908005552 malate dehydrogenase; Provisional; Region: PRK05442 862908005553 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 862908005554 NAD(P) binding site [chemical binding]; other site 862908005555 dimer interface [polypeptide binding]; other site 862908005556 malate binding site [chemical binding]; other site 862908005557 HMMPfam hit to PF00056, Lactate/malate dehydrogenase, score 2.6e-42 862908005558 HMMPfam hit to PF02866, Lactate/malate dehydrogenase, score 2e-37 862908005559 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908005560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908005561 ligand binding site [chemical binding]; other site 862908005562 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 3.8e-07 862908005563 1 probable transmembrane helix predicted for BMS1468 by TMHMM2.0 at aa 5-24 862908005564 Signal peptide predicted for BMS1468 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.724 between residues 17 and 18 862908005565 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 862908005566 Peptidase family U32; Region: Peptidase_U32; pfam01136 862908005567 HMMPfam hit to PF01136, Peptidase U32, score 1e-86 862908005568 PS01276 Peptidase family U32 signature. 862908005569 Peptidase family U32; Region: Peptidase_U32; pfam01136 862908005570 HMMPfam hit to PF01136, Peptidase U32, score 3.9e-05 862908005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 862908005572 Signal peptide predicted for BMS1471 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.945 between residues 20 and 21 862908005573 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 862908005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908005575 PS00092 N-6 Adenine-specific DNA methylases signature. 862908005576 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 862908005577 active site 862908005578 8 probable transmembrane helices predicted for BMS1474 by TMHMM2.0 at aa 17-39, 44-61, 73-95, 141-163, 176-198, 229-251, 258-280 and 284-306 862908005579 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 862908005580 putative SAM binding site [chemical binding]; other site 862908005581 homodimer interface [polypeptide binding]; other site 862908005582 HMMPfam hit to PF00590, Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase, score 9.6e-05 862908005583 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 862908005584 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862908005585 phosphate binding site [ion binding]; other site 862908005586 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 862908005587 homodimer interface [polypeptide binding]; other site 862908005588 catalytic residues [active] 862908005589 NAD binding site [chemical binding]; other site 862908005590 substrate binding pocket [chemical binding]; other site 862908005591 flexible flap; other site 862908005592 HMMPfam hit to PF00368, Hydroxymethylglutaryl-coenzyme A reductase, score 1.9e-08 862908005593 PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. 862908005594 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 862908005595 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 862908005596 diphosphomevalonate decarboxylase; Region: PLN02407 862908005597 HMMPfam hit to PF00288, GHMP kinase, score 1.2e-05 862908005598 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 862908005599 HMMPfam hit to PF00288, GHMP kinase, score 0.00015 862908005600 enoyl-CoA hydratase; Provisional; Region: PRK07659 862908005601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908005602 substrate binding site [chemical binding]; other site 862908005603 oxyanion hole (OAH) forming residues; other site 862908005604 trimer interface [polypeptide binding]; other site 862908005605 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 3.3e-11 862908005606 FecR protein; Region: FecR; pfam04773 862908005607 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908005608 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 1.3e-10 862908005609 PilZ domain; Region: PilZ; pfam07238 862908005610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908005611 Walker A motif; other site 862908005612 ATP binding site [chemical binding]; other site 862908005613 Walker B motif; other site 862908005614 arginine finger; other site 862908005615 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 2.1e-14 862908005616 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005617 Signal peptide predicted for BMS1485 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.905 between residues 25 and 26 862908005618 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 862908005619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862908005620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908005621 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.3e-75 862908005622 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 862908005623 Signal peptide predicted for BMS1488 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.711 between residues 27 and 28 862908005624 Signal peptide predicted for BMS1489 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.852 between residues 18 and 19 862908005625 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 862908005626 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.5e-40 862908005627 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 862908005628 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908005629 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 862908005630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908005631 ATP binding site [chemical binding]; other site 862908005632 putative Mg++ binding site [ion binding]; other site 862908005633 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 862908005634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 862908005635 nucleotide binding region [chemical binding]; other site 862908005636 ATP-binding site [chemical binding]; other site 862908005637 SEC-C motif; Region: SEC-C; pfam02810 862908005638 HMMPfam hit to PF02810, SEC-C motif, score 7.2e-07 862908005639 HMMPfam hit to PF07516, SecA Wing and Scaffold, score 8.1e-63 862908005640 PS01312 Protein secA signatures. 862908005641 HMMPfam hit to PF07517, SecA DEAD-like, score 1.1e-148 862908005642 HMMPfam hit to PF01043, SecA preprotein cross-linking region, score 1e-65 862908005643 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908005644 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908005645 HMMPfam hit to PF01551, Peptidase M23B, score 1.7e-51 862908005646 PS00881 Protein splicing signature. 862908005647 1 probable transmembrane helix predicted for BMS1493 by TMHMM2.0 at aa 27-49 862908005648 PS00430 TonB-dependent receptor proteins signature 1. 862908005649 Signal peptide predicted for BMS1494 by SignalP 2.0 HMM (Signal peptide probability 0.891) with cleavage site probability 0.802 between residues 18 and 19 862908005650 Signal peptide predicted for BMS1495 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.970 between residues 18 and 19 862908005651 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 862908005652 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 862908005653 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 862908005654 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 2.2e-72 862908005655 8 probable transmembrane helices predicted for BMS1497 by TMHMM2.0 at aa 7-26, 57-74, 87-109, 167-189, 209-226, 241-263, 333-355 and 375-397 862908005656 Signal peptide predicted for BMS1497 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28 862908005657 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 862908005658 HMMPfam hit to PF06934, Fatty acid cistrans isomerase, score 3.7e-245 862908005659 PS00190 Cytochrome c family heme-binding site signature. 862908005660 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 862908005661 active site 862908005662 HMMPfam hit to PF00481, Protein phosphatase 2C-like, score 5.5e-07 862908005663 PrkA AAA domain; Region: AAA_PrkA; smart00763 862908005664 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 862908005665 HMMPfam hit to PF06798, PrkA serine kinase, score 1.2e-150 862908005666 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005667 hypothetical protein; Provisional; Region: PRK05325 862908005668 HMMPfam hit to PF04285, Protein of unknown function DUF444, score 2.1e-57 862908005669 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 862908005670 SpoVR like protein; Region: SpoVR; pfam04293 862908005671 HMMPfam hit to PF04293, SpoVR, score 1.9e-67 862908005672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 862908005673 FecR protein; Region: FecR; pfam04773 862908005674 Signal peptide predicted for BMS1503 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.973 between residues 19 and 20 862908005675 Signal peptide predicted for BMS1504 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.995 between residues 19 and 20 862908005676 1 probable transmembrane helices predicted for BMS1505 by TMHMM2.0 at aa 4-26 and 39-61 862908005677 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862908005678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908005679 HMMPfam hit to PF00140, Sigma-70 region 1.2, score 7.2e-05 862908005680 HMMPfam hit to PF04542, Sigma-70 region 2, score 4.1e-19 862908005681 PS00715 Sigma-70 factors family signature 1. 862908005682 HMMPfam hit to PF04545, Sigma-70 region 4, score 3.7e-10 862908005683 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 862908005684 16S/18S rRNA binding site [nucleotide binding]; other site 862908005685 S13e-L30e interaction site [polypeptide binding]; other site 862908005686 25S rRNA binding site [nucleotide binding]; other site 862908005687 HMMPfam hit to PF00312, Ribosomal protein S15, score 3.8e-27 862908005688 PS00362 Ribosomal protein S15 signature. 862908005689 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 862908005690 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 862908005691 RNase E interface [polypeptide binding]; other site 862908005692 trimer interface [polypeptide binding]; other site 862908005693 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 862908005694 oligomer interface [polypeptide binding]; other site 862908005695 RNA binding site [nucleotide binding]; other site 862908005696 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 862908005697 putative nucleic acid binding region [nucleotide binding]; other site 862908005698 G-X-X-G motif; other site 862908005699 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 862908005700 RNA binding site [nucleotide binding]; other site 862908005701 domain interface; other site 862908005702 HMMPfam hit to PF01138, 3' exoribonuclease, score 7.6e-30 862908005703 HMMPfam hit to PF03725, 3' exoribonuclease, score 7.9e-08 862908005704 HMMPfam hit to PF01138, 3' exoribonuclease, score 2.3e-40 862908005705 HMMPfam hit to PF03725, 3' exoribonuclease, score 1.4e-22 862908005706 HMMPfam hit to PF00013, KH, type 1, score 2.4e-13 862908005707 HMMPfam hit to PF07650, KH, type 2, score 0.023 862908005708 HMMPfam hit to PF00575, RNA binding S1, score 1.6e-19 862908005709 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 862908005710 trimer interface [polypeptide binding]; other site 862908005711 active site 862908005712 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 9.4e-13 862908005713 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 862908005714 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 862908005715 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862908005716 catalytic loop [active] 862908005717 iron binding site [ion binding]; other site 862908005718 HMMPfam hit to PF00111, Ferredoxin, score 9.9e-10 862908005719 Signal peptide predicted for BMS1512 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.510 between residues 21 and 22 862908005720 Signal peptide predicted for BMS1514 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 862908005721 Signal peptide predicted for BMS1515 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.632 between residues 20 and 21 862908005722 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862908005723 Signal peptide predicted for BMS1516 by SignalP 2.0 HMM (Signal peptide probability 0.881) with cleavage site probability 0.728 between residues 38 and 39 862908005724 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 2.3e-05 862908005725 PS00134 Serine proteases, trypsin family, histidine active site. 862908005726 PS00135 Serine proteases, trypsin family, serine active site. 862908005727 FecR protein; Region: FecR; pfam04773 862908005728 Signal peptide predicted for BMS1517 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.996 between residues 16 and 17 862908005729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862908005730 GAF domain; Region: GAF; pfam01590 862908005731 PAS fold; Region: PAS_3; pfam08447 862908005732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908005733 PAS fold; Region: PAS_3; pfam08447 862908005734 putative active site [active] 862908005735 heme pocket [chemical binding]; other site 862908005736 PAS fold; Region: PAS_3; pfam08447 862908005737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908005738 dimer interface [polypeptide binding]; other site 862908005739 phosphorylation site [posttranslational modification] 862908005740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908005741 ATP binding site [chemical binding]; other site 862908005742 Mg2+ binding site [ion binding]; other site 862908005743 G-X-G motif; other site 862908005744 Response regulator receiver domain; Region: Response_reg; pfam00072 862908005745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908005746 active site 862908005747 phosphorylation site [posttranslational modification] 862908005748 intermolecular recognition site; other site 862908005749 dimerization interface [polypeptide binding]; other site 862908005750 HMMPfam hit to PF01590, GAF, score 1.2e-20 862908005751 HMMPfam hit to PF00785, PAC motif, score 3.9e-06 862908005752 HMMPfam hit to PF00785, PAC motif, score 0.00013 862908005753 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 5.5e-26 862908005754 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 8.6e-41 862908005755 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908005756 HMMPfam hit to PF00072, Response regulator receiver, score 3.4e-26 862908005757 peroxiredoxin; Region: AhpC; TIGR03137 862908005758 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 862908005759 dimer interface [polypeptide binding]; other site 862908005760 decamer (pentamer of dimers) interface [polypeptide binding]; other site 862908005761 catalytic triad [active] 862908005762 peroxidatic and resolving cysteines [active] 862908005763 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 9.3e-70 862908005764 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 862908005765 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 862908005766 catalytic residue [active] 862908005767 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908005768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862908005769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908005770 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.2e-65 862908005771 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 862908005772 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908005773 Signal peptide predicted for BMS1521 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.798 between residues 19 and 20 862908005774 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862908005775 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862908005776 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862908005777 HMMPfam hit to PF07559, Flagellar basal body FlaE, score 1.3e-05 862908005778 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005779 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 8e-11 862908005780 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908005781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908005782 non-specific DNA binding site [nucleotide binding]; other site 862908005783 salt bridge; other site 862908005784 sequence-specific DNA binding site [nucleotide binding]; other site 862908005785 HMMPfam hit to PF01381, Helix-turn-helix motif, score 5e-11 862908005786 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 862908005787 HMMPfam hit to PF02657, Fe-S metabolism associated SufE, score 4.8e-54 862908005788 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 862908005789 dimer interface [polypeptide binding]; other site 862908005790 allosteric magnesium binding site [ion binding]; other site 862908005791 active site 862908005792 aspartate-rich active site metal binding site; other site 862908005793 Schiff base residues; other site 862908005794 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 2.6e-200 862908005795 PS00169 Delta-aminolevulinic acid dehydratase active site. 862908005796 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 862908005797 PS00673 Serine proteases, V8 family, serine active site. 862908005798 PS00134 Serine proteases, trypsin family, histidine active site. 862908005799 Signal peptide predicted for BMS1529 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 22 and 23 862908005800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862908005801 HMMPfam hit to PF00753, Beta-lactamase-like, score 4.5e-22 862908005802 Signal peptide predicted for BMS1531 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.998 between residues 18 and 19 862908005803 Response regulator receiver domain; Region: Response_reg; pfam00072 862908005804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908005805 active site 862908005806 phosphorylation site [posttranslational modification] 862908005807 intermolecular recognition site; other site 862908005808 dimerization interface [polypeptide binding]; other site 862908005809 HMMPfam hit to PF00072, Response regulator receiver, score 3.2e-11 862908005810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862908005811 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908005812 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.6e-51 862908005813 4 probable transmembrane helices predicted for BMS1536 by TMHMM2.0 at aa 189-211, 232-249, 264-286 and 307-329 862908005814 Signal peptide predicted for BMS1536 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.935 between residues 19 and 20 862908005815 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 862908005816 Clp amino terminal domain; Region: Clp_N; pfam02861 862908005817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908005818 Walker A motif; other site 862908005819 ATP binding site [chemical binding]; other site 862908005820 Walker B motif; other site 862908005821 arginine finger; other site 862908005822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908005823 Walker A motif; other site 862908005824 ATP binding site [chemical binding]; other site 862908005825 Walker B motif; other site 862908005826 arginine finger; other site 862908005827 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 862908005828 HMMPfam hit to PF02861, Clp, N terminal, score 1.3e-05 862908005829 HMMPfam hit to PF00004, AAA ATPase, central region, score 2.8e-11 862908005830 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005831 PS00870 Chaperonins clpA/B signature 1. 862908005832 HMMPfam hit to PF07724, , score 1.4e-81 862908005833 HMMPfam hit to PF00004, AAA ATPase, central region, score 2.1e-05 862908005834 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005835 PS00871 Chaperonins clpA/B signature 2. 862908005836 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908005837 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908005838 ligand binding site [chemical binding]; other site 862908005839 flexible hinge region; other site 862908005840 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 8e-23 862908005841 Leucine rich repeat; Region: LRR_8; pfam13855 862908005842 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.22 862908005843 HMMPfam hit to PF00560, Leucine-rich repeat, score 5.9 862908005844 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.028 862908005845 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862908005846 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005847 Signal peptide predicted for BMS1540 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.753 between residues 34 and 35 862908005848 2 probable transmembrane helices predicted for BMS1541 by TMHMM2.0 at aa 10-29 and 36-58 862908005849 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 862908005850 tetramerization interface [polypeptide binding]; other site 862908005851 active site 862908005852 HMMPfam hit to PF02261, Aspartate decarboxylase, score 3.7e-43 862908005853 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862908005854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862908005855 phosphoserine phosphatase SerB; Region: serB; TIGR00338 862908005856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908005857 motif II; other site 862908005858 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.3e-30 862908005859 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862908005860 4 probable transmembrane helices predicted for BMS1544 by TMHMM2.0 at aa 20-42, 52-74, 95-117 and 171-193 862908005861 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 4.1e-26 862908005862 PS00379 CDP-alcohol phosphatidyltransferases signature. 862908005863 PilZ domain; Region: PilZ; pfam07238 862908005864 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 862908005865 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 862908005866 putative active site [active] 862908005867 HMMPfam hit to PF03320, GlpX, score 2.5e-179 862908005868 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 862908005869 hydrophobic ligand binding site; other site 862908005870 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 862908005871 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862908005872 catalytic residue [active] 862908005873 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.3e-05 862908005874 PS01211 Uncharacterized protein family UPF0001 signature. 862908005875 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 862908005876 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 862908005877 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 862908005878 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 2.7e-16 862908005879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862908005880 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 5.1e-09 862908005881 Fatty acid desaturase; Region: FA_desaturase; pfam00487 862908005882 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 862908005883 putative di-iron ligands [ion binding]; other site 862908005884 6 probable transmembrane helices predicted for BMS1553 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 119-141, 154-176 and 180-202 862908005885 HMMPfam hit to PF00487, Fatty acid desaturase, score 1.1e-08 862908005886 Fatty acid desaturase; Region: FA_desaturase; pfam00487 862908005887 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 862908005888 putative di-iron ligands [ion binding]; other site 862908005889 4 probable transmembrane helices predicted for BMS1554 by TMHMM2.0 at aa 12-31, 41-63, 172-194 and 214-236 862908005890 HMMPfam hit to PF00487, Fatty acid desaturase, score 2.5e-06 862908005891 Signal peptide predicted for BMS1555 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 19 and 20 862908005892 Signal peptide predicted for BMS1556 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.673 between residues 23 and 24 862908005893 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862908005894 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908005895 P-loop; other site 862908005896 Magnesium ion binding site [ion binding]; other site 862908005897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908005898 Magnesium ion binding site [ion binding]; other site 862908005899 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 2.7e-29 862908005900 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 862908005901 Signal peptide predicted for BMS1561 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.532 between residues 16 and 17 862908005902 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 862908005903 putative active site [active] 862908005904 putative metal binding site [ion binding]; other site 862908005905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908005906 DltD central region; Region: DltD_M; pfam04918 862908005907 Signal peptide predicted for BMS1563 by SignalP 2.0 HMM (Signal peptide probability 0.689) with cleavage site probability 0.633 between residues 19 and 20 862908005908 Response regulator receiver domain; Region: Response_reg; pfam00072 862908005909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908005910 active site 862908005911 phosphorylation site [posttranslational modification] 862908005912 intermolecular recognition site; other site 862908005913 dimerization interface [polypeptide binding]; other site 862908005914 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-17 862908005915 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862908005916 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 862908005917 DXD motif; other site 862908005918 5 probable transmembrane helices predicted for BMS1565 by TMHMM2.0 at aa 7-29, 49-71, 324-346, 361-383 and 390-412 862908005919 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.8e-40 862908005920 1 probable transmembrane helix predicted for BMS1566 by TMHMM2.0 at aa 7-29 862908005921 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 862908005922 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 862908005923 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3e-76 862908005924 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 862908005925 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 862908005926 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 4e-110 862908005927 Preprotein translocase subunit; Region: YajC; pfam02699 862908005928 1 probable transmembrane helix predicted for BMS1570 by TMHMM2.0 at aa 20-42 862908005929 HMMPfam hit to PF02699, YajC, score 9.5e-28 862908005930 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 862908005931 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 1.4e-13 862908005932 1 probable transmembrane helix predicted for BMS1571 by TMHMM2.0 at aa 4-21 862908005933 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 862908005934 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 862908005935 Signal peptide predicted for BMS1572 by SignalP 2.0 HMM (Signal peptide probability 0.741) with cleavage site probability 0.407 between residues 31 and 32 862908005936 6 probable transmembrane helices predicted for BMS1572 by TMHMM2.0 at aa 5-27, 411-428, 435-457, 461-483, 504-526 and 530-552 862908005937 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 0.0014 862908005938 PS00017 ATP/GTP-binding site motif A (P-loop). 862908005939 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 1.1e-08 862908005940 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005941 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 862908005942 Protein export membrane protein; Region: SecD_SecF; pfam02355 862908005943 Signal peptide predicted for BMS1573 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.878 between residues 34 and 35 862908005944 5 probable transmembrane helices predicted for BMS1573 by TMHMM2.0 at aa 13-35, 138-157, 178-200, 242-264 and 271-293 862908005945 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 0.00022 862908005946 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 2.9e-67 862908005947 PS00860 GTP cyclohydrolase I signature 2. 862908005948 2 probable transmembrane helices predicted for BMS1574 by TMHMM2.0 at aa 129-147 and 168-190 862908005949 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862908005950 IHF - DNA interface [nucleotide binding]; other site 862908005951 IHF dimer interface [polypeptide binding]; other site 862908005952 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 3e-33 862908005953 Signal peptide predicted for BMS1579 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.792 between residues 18 and 19 862908005954 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 862908005955 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 7.9e-26 862908005956 2 probable transmembrane helices predicted for BMS1580 by TMHMM2.0 at aa 175-194 and 209-231 862908005957 hypothetical protein; Validated; Region: PRK08223 862908005958 ThiF family; Region: ThiF; pfam00899 862908005959 ATP binding site [chemical binding]; other site 862908005960 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 4.5e-21 862908005961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908005962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862908005963 dimer interface [polypeptide binding]; other site 862908005964 phosphorylation site [posttranslational modification] 862908005965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908005966 ATP binding site [chemical binding]; other site 862908005967 Mg2+ binding site [ion binding]; other site 862908005968 G-X-G motif; other site 862908005969 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-17 862908005970 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0025 862908005971 hypothetical protein; Provisional; Region: PRK05170 862908005972 HMMPfam hit to PF05779, Uncharacterised conserved protein UCP006173, score 3.4e-62 862908005973 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 862908005974 Signal peptide predicted for BMS1586 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 18 and 19 862908005975 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, score 5e-38 862908005976 Bacterial SH3 domain; Region: SH3_3; cl17532 862908005977 1 probable transmembrane helix predicted for BMS1588 by TMHMM2.0 at aa 141-163 862908005978 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908005979 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 862908005980 active site 862908005981 Zn binding site [ion binding]; other site 862908005982 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 2.4e-51 862908005983 PS00881 Protein splicing signature. 862908005984 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862908005985 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 862908005986 Signal peptide predicted for BMS1590 by SignalP 2.0 HMM (Signal peptide probability 0.660) with cleavage site probability 0.320 between residues 22 and 23 862908005987 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005988 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 862908005989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 862908005990 active site 862908005991 HMMPfam hit to PF01844, HNH endonuclease, score 1.2e-08 862908005992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862908005993 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908005994 Signal peptide predicted for BMS1595 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908005995 Signal peptide predicted for BMS1596 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 29 and 30 862908005996 1 probable transmembrane helix predicted for BMS1596 by TMHMM2.0 at aa 9-31 862908005997 Signal peptide predicted for BMS1597 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.972 between residues 36 and 37 862908005998 1 probable transmembrane helix predicted for BMS1597 by TMHMM2.0 at aa 21-43 862908005999 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 862908006000 putative fimbrial protein TcfA; Provisional; Region: PRK15308 862908006001 Signal peptide predicted for BMS1598 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.381 between residues 18 and 19 862908006002 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 862908006003 Signal peptide predicted for BMS1599 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 19 and 20 862908006004 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0.0013 862908006005 Signal peptide predicted for BMS1600 by SignalP 2.0 HMM (Signal peptide probability 0.618) with cleavage site probability 0.610 between residues 17 and 18 862908006006 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 862908006007 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 862908006008 active site 862908006009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862908006010 active site 862908006011 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.4e-24 862908006012 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 3e-09 862908006013 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 862908006014 AIR carboxylase; Region: AIRC; cl00310 862908006015 HMMPfam hit to PF00731, 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase, score 6.2e-20 862908006016 ATP binding site [chemical binding]; other site 862908006017 active site 862908006018 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 862908006019 substrate binding site [chemical binding]; other site 862908006020 HMMPfam hit to PF01259, SAICAR synthetase, score 1.8e-06 862908006021 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 862908006022 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 862908006023 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908006024 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 862908006025 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, score 2.7e-22 862908006026 HMMPfam hit to PF02842, Phosphoribosylglycinamide synthetase, score 2.4e-16 862908006027 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, score 4.1e-51 862908006028 PS00184 Phosphoribosylglycinamide synthetase signature. 862908006029 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, score 4.5e-08 862908006030 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 862908006031 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 862908006032 dimerization interface [polypeptide binding]; other site 862908006033 ATP binding site [chemical binding]; other site 862908006034 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 862908006035 ATP binding site [chemical binding]; other site 862908006036 dimerization interface [polypeptide binding]; other site 862908006037 HMMPfam hit to PF00586, AIR synthase related protein, score 1e-28 862908006038 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 2.2e-29 862908006039 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 1e-05 862908006040 phosphoribosylformylglycinamidine synthase I; Region: FGAM_synth_I; TIGR01737 862908006041 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 862908006042 conserved cys residue [active] 862908006043 PS00442 Glutamine amidotransferases class-I active site. 862908006044 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 862908006045 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 862908006046 purine monophosphate binding site [chemical binding]; other site 862908006047 dimer interface [polypeptide binding]; other site 862908006048 putative catalytic residues [active] 862908006049 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 862908006050 HMMPfam hit to PF02142, Methylglyoxal synthase-like, score 9.7e-31 862908006051 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 5e-75 862908006052 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 862908006053 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 862908006054 dimerization interface [polypeptide binding]; other site 862908006055 putative ATP binding site [chemical binding]; other site 862908006056 HMMPfam hit to PF00586, AIR synthase related protein, score 4.3e-53 862908006057 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006058 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 2.4e-12 862908006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908006060 S-adenosylmethionine binding site [chemical binding]; other site 862908006061 Signal peptide predicted for BMS1612 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 22 and 23 862908006062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908006063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908006064 dimer interface [polypeptide binding]; other site 862908006065 phosphorylation site [posttranslational modification] 862908006066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908006067 ATP binding site [chemical binding]; other site 862908006068 Mg2+ binding site [ion binding]; other site 862908006069 G-X-G motif; other site 862908006070 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9.5e-16 862908006071 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.9e-05 862908006072 9 probable transmembrane helices predicted for BMS1613 by TMHMM2.0 at aa 10-32, 163-185, 195-214, 227-246, 251-273, 285-302, 312-331, 344-366 and 372-394 862908006073 Signal peptide predicted for BMS1614 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 20 and 21 862908006074 Signal peptide predicted for BMS1615 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.853 between residues 27 and 28 862908006075 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 862908006076 Signal peptide predicted for BMS1616 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.395 between residues 31 and 32 862908006077 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 862908006078 active site 862908006079 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 862908006080 active site 862908006081 Signal peptide predicted for BMS1617 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.978 between residues 18 and 19 862908006082 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 862908006083 hypothetical protein; Provisional; Region: PRK09256 862908006084 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 862908006085 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862908006086 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006087 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006088 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006089 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006090 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006091 Signal peptide predicted for BMS1619 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.786 between residues 24 and 25 862908006092 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 862908006093 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 862908006094 G1 box; other site 862908006095 putative GEF interaction site [polypeptide binding]; other site 862908006096 GTP/Mg2+ binding site [chemical binding]; other site 862908006097 Switch I region; other site 862908006098 G2 box; other site 862908006099 G3 box; other site 862908006100 Switch II region; other site 862908006101 G4 box; other site 862908006102 G5 box; other site 862908006103 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 862908006104 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 5.1e-10 862908006105 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 9.4e-52 862908006106 PS00301 GTP-binding elongation factors signature. 862908006107 1 probable transmembrane helix predicted for BMS1621 by TMHMM2.0 at aa 17-39 862908006108 Signal peptide predicted for BMS1621 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 36 and 37 862908006109 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862908006110 active site 862908006111 oxyanion hole [active] 862908006112 1 probable transmembrane helix predicted for BMS1623 by TMHMM2.0 at aa 5-27 862908006113 Signal peptide predicted for BMS1623 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.868 between residues 26 and 27 862908006114 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862908006115 Signal peptide predicted for BMS1624 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 862908006116 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 862908006117 aromatic arch; other site 862908006118 DCoH dimer interaction site [polypeptide binding]; other site 862908006119 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 862908006120 DCoH tetramer interaction site [polypeptide binding]; other site 862908006121 substrate binding site [chemical binding]; other site 862908006122 HMMPfam hit to PF01329, Transcriptional coactivator/pterin dehydratase, score 1.1e-09 862908006123 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 862908006124 Signal peptide predicted for BMS1626 by SignalP 2.0 HMM (Signal peptide probability 0.828) with cleavage site probability 0.754 between residues 15 and 16 862908006125 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908006126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908006127 non-specific DNA binding site [nucleotide binding]; other site 862908006128 salt bridge; other site 862908006129 sequence-specific DNA binding site [nucleotide binding]; other site 862908006130 Cupin domain; Region: Cupin_2; pfam07883 862908006131 HMMPfam hit to PF01381, Helix-turn-helix motif, score 4.3e-20 862908006132 superoxide dismutase; Provisional; Region: PRK10543 862908006133 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 862908006134 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 862908006135 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 2.8e-44 862908006136 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 2.3e-61 862908006137 PS00088 Manganese and iron superoxide dismutases signature. 862908006138 Signal peptide predicted for BMS1630 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.472 between residues 51 and 52 862908006139 2 probable transmembrane helices predicted for BMS1630 by TMHMM2.0 at aa 5-27 and 31-50 862908006140 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 862908006141 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 862908006142 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 862908006143 9 probable transmembrane helices predicted for BMS1631 by TMHMM2.0 at aa 4-21, 50-72, 82-104, 111-125, 135-157, 178-200, 215-237, 249-271 and 295-317 862908006144 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006145 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 6.4e-55 862908006146 MarR family; Region: MarR_2; cl17246 862908006147 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862908006148 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 4.6e-14 862908006149 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 862908006150 catalytic residues [active] 862908006151 dimer interface [polypeptide binding]; other site 862908006152 HMMPfam hit to PF00255, Glutathione peroxidase, score 4.5e-37 862908006153 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 862908006154 Type II/IV secretion system protein; Region: T2SE; pfam00437 862908006155 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 862908006156 ATP binding site [chemical binding]; other site 862908006157 Walker A motif; other site 862908006158 hexamer interface [polypeptide binding]; other site 862908006159 Walker B motif; other site 862908006160 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 9.7e-82 862908006161 PS00227 Tubulin subunits alpha, beta, and gamma signature. 862908006162 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006163 Similar to N-terminus of Pseudomonas chlororaphis (pseudomonas aureofaciens). putative uncharacterized protein (fragment). UniProt:Q840I1 (EMBL:AY163857 (127 aa) fasta scores: E()=6, 25.373% id in 67 aa 862908006164 Signal peptide predicted for BMS1638 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.888 between residues 21 and 22 862908006165 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 862908006166 Signal peptide predicted for BMS1639 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.837 between residues 26 and 27 862908006167 COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...; Region: Commd; cl06336 862908006168 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862908006169 active site 862908006170 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908006171 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862908006172 HMMPfam hit to PF01177, Asp/Glu racemase, score 8.4e-42 862908006173 PS00924 Aspartate and glutamate racemases signature 2. 862908006174 enolase; Provisional; Region: eno; PRK00077 862908006175 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862908006176 dimer interface [polypeptide binding]; other site 862908006177 metal binding site [ion binding]; metal-binding site 862908006178 substrate binding pocket [chemical binding]; other site 862908006179 HMMPfam hit to PF03952, Enolase, score 1.6e-64 862908006180 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006181 HMMPfam hit to PF00113, Enolase, score 1.1e-145 862908006182 PS00164 Enolase signature. 862908006183 4 probable transmembrane helices predicted for BMS1645 by TMHMM2.0 at aa 13-35, 91-113, 126-144 and 154-176 862908006184 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908006185 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.017 862908006186 Signal peptide predicted for BMS1646 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.942 between residues 18 and 19 862908006187 Signal peptide predicted for BMS1647 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24 862908006188 1 probable transmembrane helix predicted for BMS1647 by TMHMM2.0 at aa 217-239 862908006189 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862908006190 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 862908006191 acyl-activating enzyme (AAE) consensus motif; other site 862908006192 AMP binding site [chemical binding]; other site 862908006193 active site 862908006194 CoA binding site [chemical binding]; other site 862908006195 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 862908006196 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 6.2e-07 862908006197 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 2e-07 862908006198 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 862908006199 active site 862908006200 DNA polymerase IV; Validated; Region: PRK02406 862908006201 DNA binding site [nucleotide binding] 862908006202 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 2.1e-83 862908006203 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 862908006204 LexA repressor; Validated; Region: PRK00215 862908006205 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862908006206 Catalytic site [active] 862908006207 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, score 6.4e-16 862908006208 HMMPfam hit to PF01726, LexA DNA-binding region, score 1.1e-07 862908006209 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862908006210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862908006211 3 probable transmembrane helices predicted for BMS1652 by TMHMM2.0 at aa 35-57, 77-96 and 106-128 862908006212 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.3e-13 862908006213 Signal peptide predicted for BMS1653 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.525 between residues 21 and 22 862908006214 C factor cell-cell signaling protein; Provisional; Region: PRK09009 862908006215 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 862908006216 NADP binding site [chemical binding]; other site 862908006217 homodimer interface [polypeptide binding]; other site 862908006218 active site 862908006219 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 6.4e-08 862908006220 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 862908006221 Signal peptide predicted for BMS1655 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 32 and 33 862908006222 Signal peptide predicted for BMS1656 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 20 and 21 862908006223 Signal peptide predicted for BMS1657 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.602 between residues 25 and 26 862908006224 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006225 Signal peptide predicted for BMS1658 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.545 between residues 17 and 18 862908006226 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006227 O-succinylbenzoate synthase; Provisional; Region: PRK02714 862908006228 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 862908006229 metal binding site [ion binding]; metal-binding site 862908006230 substrate binding pocket [chemical binding]; other site 862908006231 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 862908006232 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 862908006233 UbiA prenyltransferase family; Region: UbiA; pfam01040 862908006234 8 probable transmembrane helices predicted for BMS1660 by TMHMM2.0 at aa 38-60, 84-106, 110-132, 139-161, 171-193, 214-236, 240-257 and 269-291 862908006235 HMMPfam hit to PF01040, UbiA prenyltransferase, score 8.1e-21 862908006236 Signal peptide predicted for BMS1660 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.981 between residues 31 and 32 862908006237 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 862908006238 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 862908006239 dimer interface [polypeptide binding]; other site 862908006240 tetramer interface [polypeptide binding]; other site 862908006241 PYR/PP interface [polypeptide binding]; other site 862908006242 TPP binding site [chemical binding]; other site 862908006243 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 862908006244 TPP-binding site; other site 862908006245 HMMPfam hit to PF02776, Pyruvate decarboxylase, score 0.00067 862908006246 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862908006247 HMMPfam hit to PF00425, Anthranilate synthase component I and chorismate binding protein, score 4e-42 862908006248 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 862908006249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908006250 S-adenosylmethionine binding site [chemical binding]; other site 862908006251 HMMPfam hit to PF01209, UbiE/COQ5 methyltransferase, score 2.1e-55 862908006252 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 862908006253 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 862908006254 substrate binding pocket [chemical binding]; other site 862908006255 chain length determination region; other site 862908006256 substrate-Mg2+ binding site; other site 862908006257 catalytic residues [active] 862908006258 aspartate-rich region 1; other site 862908006259 active site lid residues [active] 862908006260 aspartate-rich region 2; other site 862908006261 PS00430 TonB-dependent receptor proteins signature 1. 862908006262 HMMPfam hit to PF00348, Polyprenyl synthetase, score 3e-30 862908006263 Signal peptide predicted for BMS1665 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.981 between residues 24 and 25 862908006264 proline aminopeptidase P II; Provisional; Region: PRK10879 862908006265 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 862908006266 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 862908006267 active site 862908006268 HMMPfam hit to PF00557, Peptidase M24, score 3.6e-75 862908006269 PS00491 Aminopeptidase P and proline dipeptidase signature. 862908006270 HMMPfam hit to PF05195, Peptidase M24B, X-Pro dipeptidase/aminopeptidase N-terminal, score 9.2e-38 862908006271 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 862908006272 dimer interface [polypeptide binding]; other site 862908006273 substrate binding site [chemical binding]; other site 862908006274 metal binding sites [ion binding]; metal-binding site 862908006275 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 4.5e-64 862908006276 Signal peptide predicted for BMS1668 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.758 between residues 19 and 20 862908006277 BCCT family transporter; Region: BCCT; pfam02028 862908006278 HMMPfam hit to PF02028, BCCT transporter, score 3.9e-212 862908006279 12 probable transmembrane helices predicted for BMS1669 by TMHMM2.0 at aa 13-31, 46-68, 89-111, 139-161, 190-212, 227-249, 256-278, 311-333, 346-365, 399-421, 446-468 and 472-491 862908006280 PS01303 BCCT family of transporters signature. 862908006281 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 862908006282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908006283 active site 862908006284 nucleotide binding site [chemical binding]; other site 862908006285 HIGH motif; other site 862908006286 KMSKS motif; other site 862908006287 HMMPfam hit to PF01921, Lysyl-tRNA synthetase (archaeal), class 1c, score 2.4e-199 862908006288 Signal peptide predicted for BMS1673 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.686 between residues 31 and 32 862908006289 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 862908006290 Signal peptide predicted for BMS1674 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 19 and 20 862908006291 PS00018 EF-hand calcium-binding domain. 862908006292 methionine aminotransferase; Validated; Region: PRK09082 862908006293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862908006294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908006295 homodimer interface [polypeptide binding]; other site 862908006296 catalytic residue [active] 862908006297 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.4e-30 862908006298 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862908006299 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862908006300 Walker A/P-loop; other site 862908006301 ATP binding site [chemical binding]; other site 862908006302 Q-loop/lid; other site 862908006303 ABC transporter signature motif; other site 862908006304 Walker B; other site 862908006305 D-loop; other site 862908006306 H-loop/switch region; other site 862908006307 HMMPfam hit to PF00005, ABC transporter, score 9.5e-45 862908006308 PS00211 ABC transporters family signature. 862908006309 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006310 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862908006311 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862908006312 Walker A/P-loop; other site 862908006313 ATP binding site [chemical binding]; other site 862908006314 Q-loop/lid; other site 862908006315 ABC transporter signature motif; other site 862908006316 Walker B; other site 862908006317 D-loop; other site 862908006318 H-loop/switch region; other site 862908006319 HMMPfam hit to PF00005, ABC transporter, score 7.6e-54 862908006320 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908006321 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006322 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862908006323 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862908006324 TM-ABC transporter signature motif; other site 862908006325 8 probable transmembrane helices predicted for BMS1678 by TMHMM2.0 at aa 5-27, 32-54, 64-86, 93-110, 130-147, 180-199, 214-236 and 257-274 862908006326 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 9.2e-36 862908006327 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862908006329 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862908006330 TM-ABC transporter signature motif; other site 862908006331 8 probable transmembrane helices predicted for BMS1679 by TMHMM2.0 at aa 15-37, 42-64, 69-91, 100-122, 144-166, 196-218, 233-266 and 273-292 862908006332 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.7e-46 862908006333 PS00678 Trp-Asp (WD) repeats signature. 862908006334 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862908006335 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 862908006336 putative ligand binding site [chemical binding]; other site 862908006337 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 4.2e-46 862908006338 Signal peptide predicted for BMS1680 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.761 between residues 46 and 47 862908006339 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 862908006340 HMMPfam hit to PF07075, Uncharacterised conserved protein UCP016719, score 2.2e-116 862908006341 thymidylate synthase; Reviewed; Region: thyA; PRK01827 862908006342 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 862908006343 dimerization interface [polypeptide binding]; other site 862908006344 active site 862908006345 HMMPfam hit to PF00303, Thymidylate synthase, score 2.3e-178 862908006346 PS00091 Thymidylate synthase active site. 862908006347 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 862908006348 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 862908006349 NADP+ binding site [chemical binding]; other site 862908006350 folate binding site [chemical binding]; other site 862908006351 HMMPfam hit to PF00186, Dihydrofolate reductase, score 1.2e-10 862908006352 Maf-like protein; Region: Maf; pfam02545 862908006353 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 862908006354 active site 862908006355 dimer interface [polypeptide binding]; other site 862908006356 HMMPfam hit to PF02545, Maf-like protein, score 5.2e-43 862908006357 FecR protein; Region: FecR; pfam04773 862908006358 Signal peptide predicted for BMS1689 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 18 and 19 862908006359 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 862908006360 HMMPfam hit to PF05973, Bacterial protein of unknown function DUF891, score 1.8e-15 862908006361 PS00228 Tubulin-beta mRNA autoregulation signal. 862908006362 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 862908006363 ATP cone domain; Region: ATP-cone; pfam03477 862908006364 Class I ribonucleotide reductase; Region: RNR_I; cd01679 862908006365 active site 862908006366 dimer interface [polypeptide binding]; other site 862908006367 catalytic residues [active] 862908006368 effector binding site; other site 862908006369 R2 peptide binding site; other site 862908006370 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, score 0 862908006371 PS00089 Ribonucleotide reductase large subunit signature. 862908006372 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, score 4.6e-33 862908006373 HMMPfam hit to PF03477, ATP-cone, score 1.7e-17 862908006374 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 862908006375 dimer interface [polypeptide binding]; other site 862908006376 putative radical transfer pathway; other site 862908006377 diiron center [ion binding]; other site 862908006378 tyrosyl radical; other site 862908006379 HMMPfam hit to PF00268, Ribonucleotide reductase, score 5.2e-139 862908006380 1 probable transmembrane helix predicted for BMS1695 by TMHMM2.0 at aa 155-177 862908006381 PS00368 Ribonucleotide reductase small subunit signature. 862908006382 Domain of unknown function DUF21; Region: DUF21; pfam01595 862908006383 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862908006384 HMMPfam hit to PF00571, CBS, score 8.4e-06 862908006385 HMMPfam hit to PF00571, CBS, score 0.03 862908006386 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 2.5e-20 862908006387 3 probable transmembrane helices predicted for BMS1696 by TMHMM2.0 at aa 4-26, 82-104 and 119-141 862908006388 Signal peptide predicted for BMS1696 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.728 between residues 23 and 24 862908006389 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862908006390 active site 862908006391 DNA binding site [nucleotide binding] 862908006392 Int/Topo IB signature motif; other site 862908006393 HMMPfam hit to PF00589, Phage integrase, score 8.4e-16 862908006394 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.00089 862908006395 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 862908006396 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 862908006397 active site 862908006398 HMMPfam hit to PF01804, Peptidase S45, penicillin amidase, score 2.6e-43 862908006399 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862908006400 putative acyl-acceptor binding pocket; other site 862908006401 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 5.1e-44 862908006402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862908006403 1 probable transmembrane helix predicted for BMS1702 by TMHMM2.0 at aa 13-35 862908006404 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006405 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 862908006406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862908006407 active site 862908006408 DNA binding site [nucleotide binding] 862908006409 Int/Topo IB signature motif; other site 862908006410 HMMPfam hit to PF00589, Phage integrase, score 5.4e-14 862908006411 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.0037 862908006412 1 probable transmembrane helix predicted for BMS1705 by TMHMM2.0 at aa 46-68 862908006413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 862908006414 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 862908006415 HMMPfam hit to PF04055, Radical SAM, score 0.00098 862908006416 1 probable transmembrane helix predicted for BMS1707 by TMHMM2.0 at aa 15-37 862908006417 1 probable transmembrane helix predicted for BMS1708 by TMHMM2.0 at aa 27-49 862908006418 1 probable transmembrane helix predicted for BMS1709 by TMHMM2.0 at aa 7-28 862908006419 Signal peptide predicted for BMS1709 by SignalP 2.0 HMM (Signal peptide probability 0.773) with cleavage site probability 0.443 between residues 22 and 23 862908006420 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 862908006421 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 4.1e-36 862908006422 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 862908006423 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 3.2e-64 862908006424 Ion channel; Region: Ion_trans_2; pfam07885 862908006425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908006426 ligand binding site [chemical binding]; other site 862908006427 flexible hinge region; other site 862908006428 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 7.3e-27 862908006429 PS00888 Cyclic nucleotide-binding domain signature 1. 862908006430 6 probable transmembrane helices predicted for BMS1712 by TMHMM2.0 at aa 13-35, 45-64, 84-106, 141-160, 181-203 and 207-229 862908006431 HMMPfam hit to PF00520, Ion transport protein, score 1e-15 862908006432 Signal peptide predicted for BMS1712 by SignalP 2.0 HMM (Signal peptide probability 0.675) with cleavage site probability 0.339 between residues 36 and 37 862908006433 heat shock protein HtpX; Provisional; Region: PRK05457 862908006434 HMMPfam hit to PF06509, HtpX, N-terminal, score 2.9e-32 862908006435 4 probable transmembrane helices predicted for BMS1713 by TMHMM2.0 at aa 5-27, 37-59, 157-179 and 194-216 862908006436 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 1.2e-39 862908006437 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 862908006438 DNA methylase; Region: N6_N4_Mtase; pfam01555 862908006439 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 2.5e-14 862908006440 PS00092 N-6 Adenine-specific DNA methylases signature. 862908006441 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908006442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908006443 substrate binding pocket [chemical binding]; other site 862908006444 membrane-bound complex binding site; other site 862908006445 hinge residues; other site 862908006446 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 862908006447 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862908006448 FMN binding site [chemical binding]; other site 862908006449 substrate binding site [chemical binding]; other site 862908006450 putative catalytic residue [active] 862908006451 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, NPD, score 4.1e-81 862908006452 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908006453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 862908006454 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 862908006455 Signal peptide predicted for BMS1720 by SignalP 2.0 HMM (Signal peptide probability 0.666) with cleavage site probability 0.252 between residues 20 and 21 862908006456 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006457 Signal peptide predicted for BMS1722 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 18 and 19 862908006458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908006459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908006460 active site 862908006461 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 1.3e-47 862908006462 PS00073 Acyl-CoA dehydrogenases signature 2. 862908006463 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 3.7e-17 862908006464 1 probable transmembrane helix predicted for BMS1724 by TMHMM2.0 at aa 7-26 862908006465 Signal peptide predicted for BMS1724 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 25 and 26 862908006466 Signal peptide predicted for BMS1726 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.446 between residues 18 and 19 862908006467 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006468 Predicted membrane protein [Function unknown]; Region: COG2259 862908006469 4 probable transmembrane helices predicted for BMS1727 by TMHMM2.0 at aa 7-24, 44-66, 71-90 and 100-119 862908006470 HMMPfam hit to PF07681, , score 2.7e-24 862908006471 Signal peptide predicted for BMS1727 by SignalP 2.0 HMM (Signal peptide probability 0.764) with cleavage site probability 0.294 between residues 23 and 24 862908006472 DTW domain; Region: DTW; cl01221 862908006473 HMMPfam hit to PF03942, DTW, score 1.2e-27 862908006474 1 probable transmembrane helix predicted for BMS1729 by TMHMM2.0 at aa 17-39 862908006475 Signal peptide predicted for BMS1731 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.432 between residues 19 and 20 862908006476 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006477 Signal peptide predicted for BMS1732 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.956 between residues 20 and 21 862908006478 Signal peptide predicted for BMS1733 by SignalP 2.0 HMM (Signal peptide probability 0.890) with cleavage site probability 0.841 between residues 18 and 19 862908006479 Signal peptide predicted for BMS1734 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.720 between residues 18 and 19 862908006480 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 862908006481 protein-splicing catalytic site; other site 862908006482 thioester formation/cholesterol transfer; other site 862908006483 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908006484 active site 862908006485 catalytic residues [active] 862908006486 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006487 Signal peptide predicted for BMS1737 by SignalP 2.0 HMM (Signal peptide probability 0.838) with cleavage site probability 0.559 between residues 22 and 23 862908006488 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 862908006489 Galactose oxidase, central domain; Region: Kelch_3; cl02701 862908006490 Kelch motif; Region: Kelch_1; pfam01344 862908006491 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 862908006492 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 862908006493 Kelch motif; Region: Kelch_6; pfam13964 862908006494 Signal peptide predicted for BMS1738 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.997 between residues 19 and 20 862908006495 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.085 862908006496 HMMPfam hit to PF00560, Leucine-rich repeat, score 20 862908006497 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.87 862908006498 HMMPfam hit to PF00560, Leucine-rich repeat, score 31 862908006499 HMMPfam hit to PF01344, Kelch repeat, score 0.75 862908006500 HMMPfam hit to PF01344, Kelch repeat, score 0.1 862908006501 HMMPfam hit to PF01344, Kelch repeat, score 0.0014; HMMPfam hit to PF07646, Kelch, score 0.13 862908006502 HMMPfam hit to PF07646, Kelch, score 0.02 862908006503 HMMPfam hit to PF01344, Kelch repeat, score 0.00053 862908006504 HMMPfam hit to PF01344, Kelch repeat, score 0.27 862908006505 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 862908006506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 862908006507 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, score 6.8e-61 862908006508 PS01103 Aspartate-semialdehyde dehydrogenase signature. 862908006509 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, score 3.6e-30 862908006510 aspartate kinase III; Validated; Region: PRK09084 862908006511 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 862908006512 nucleotide binding site [chemical binding]; other site 862908006513 substrate binding site [chemical binding]; other site 862908006514 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 862908006515 lysine allosteric regulatory site; other site 862908006516 dimer interface [polypeptide binding]; other site 862908006517 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862908006518 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2.7e-45 862908006519 PS00324 Aspartokinase signature. 862908006520 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.0038 862908006521 dihydrodipicolinate reductase; Provisional; Region: PRK00048 862908006522 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 862908006523 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006524 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, score 6.1e-20 862908006525 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 862908006526 dihydrodipicolinate synthase; Region: dapA; TIGR00674 862908006527 dimer interface [polypeptide binding]; other site 862908006528 active site 862908006529 catalytic residue [active] 862908006530 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 4.9e-37 862908006531 PS00665 Dihydrodipicolinate synthetase signature 1. 862908006532 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 862908006533 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 862908006534 trimer interface [polypeptide binding]; other site 862908006535 active site 862908006536 substrate binding site [chemical binding]; other site 862908006537 CoA binding site [chemical binding]; other site 862908006538 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 35 862908006539 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 19 862908006540 PS00101 Hexapeptide-repeat containing-transferases signature. 862908006541 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.2 862908006542 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.18 862908006543 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9 862908006544 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 862908006545 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 862908006546 active site 862908006547 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862908006548 dimer interface [polypeptide binding]; other site 862908006549 catalytic residues [active] 862908006550 substrate binding site [chemical binding]; other site 862908006551 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 1.1e-16 862908006552 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 862908006553 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 2.9e-16 862908006554 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908006555 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 862908006556 active site 862908006557 Zn binding site [ion binding]; other site 862908006558 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 2.2e-20 862908006559 Signal peptide predicted for BMS1749 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.920 between residues 21 and 22 862908006560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862908006561 PS00435 Peroxidases proximal heme-ligand signature. 862908006562 Signal peptide predicted for BMS1751 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.832 between residues 26 and 27 862908006563 Signal peptide predicted for BMS1752 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.966 between residues 20 and 21 862908006564 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 862908006565 Predicted dehydrogenase [General function prediction only]; Region: COG5322 862908006566 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 862908006567 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 862908006568 putative NAD(P) binding site [chemical binding]; other site 862908006569 active site 862908006570 putative substrate binding site [chemical binding]; other site 862908006571 putative lipid kinase; Reviewed; Region: PRK00861 862908006572 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 862908006573 Zinc-binding domain; Region: zf-3CxxC; pfam13695 862908006574 Signal peptide predicted for BMS1757 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.940 between residues 27 and 28 862908006575 Signal peptide predicted for BMS1758 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.918 between residues 16 and 17 862908006576 FOG: PKD repeat [General function prediction only]; Region: COG3291 862908006577 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 862908006578 FOG: PKD repeat [General function prediction only]; Region: COG3291 862908006579 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 862908006580 FOG: PKD repeat [General function prediction only]; Region: COG3291 862908006581 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 862908006582 Signal peptide predicted for BMS1760 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.636 between residues 21 and 22 862908006583 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 862908006584 HMMPfam hit to PF05724, Thiopurine S-methyltransferase, score 8.8e-41 862908006585 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 862908006586 HMMPfam hit to PF00873, Acriflavin resistance protein, score 1.4e-277 862908006587 12 probable transmembrane helices predicted for BMS1764 by TMHMM2.0 at aa 13-30, 336-358, 365-387, 397-419, 442-464, 479-501, 529-551, 868-887, 894-916, 920-942, 971-990 and 1005-1027 862908006588 Signal peptide predicted for BMS1764 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.376 between residues 32 and 33 862908006589 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 862908006590 HlyD family secretion protein; Region: HlyD_3; pfam13437 862908006591 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006592 Signal peptide predicted for BMS1766 by SignalP 2.0 HMM (Signal peptide probability 0.792) with cleavage site probability 0.479 between residues 16 and 17 862908006593 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908006594 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908006595 catalytic residues [active] 862908006596 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 5.1e-10 862908006597 Signal peptide predicted for BMS1767 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.944 between residues 18 and 19 862908006598 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862908006599 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 862908006600 dimerization interface [polypeptide binding]; other site 862908006601 ligand binding site [chemical binding]; other site 862908006602 NADP binding site [chemical binding]; other site 862908006603 catalytic site [active] 862908006604 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 5.8e-22 862908006605 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 5.6e-50 862908006606 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 862908006607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908006608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908006609 active site 862908006610 phosphorylation site [posttranslational modification] 862908006611 intermolecular recognition site; other site 862908006612 dimerization interface [polypeptide binding]; other site 862908006613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908006614 DNA binding site [nucleotide binding] 862908006615 HMMPfam hit to PF00072, Response regulator receiver, score 2.1e-30 862908006616 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-17 862908006617 Response regulator receiver domain; Region: Response_reg; pfam00072 862908006618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908006619 active site 862908006620 phosphorylation site [posttranslational modification] 862908006621 intermolecular recognition site; other site 862908006622 dimerization interface [polypeptide binding]; other site 862908006623 HMMPfam hit to PF00072, Response regulator receiver, score 1.9e-17 862908006624 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 862908006625 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 862908006626 active site 862908006627 catalytic triad [active] 862908006628 1 probable transmembrane helix predicted for BMS1772 by TMHMM2.0 at aa 481-500 862908006629 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.4e-74 862908006630 PS00138 Serine proteases, subtilase family, serine active site. 862908006631 PS00137 Serine proteases, subtilase family, histidine active site. 862908006632 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908006633 Signal peptide predicted for BMS1772 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 25 and 26 862908006634 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 862908006635 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 862908006636 Na binding site [ion binding]; other site 862908006637 Signal peptide predicted for BMS1773 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.576 between residues 21 and 22 862908006638 10 probable transmembrane helices predicted for BMS1773 by TMHMM2.0 at aa 69-91, 111-128, 141-163, 173-195, 208-230, 250-272, 333-352, 357-379, 386-404 and 419-441 862908006639 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 862908006640 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908006641 active site 862908006642 PS00673 Serine proteases, V8 family, serine active site. 862908006643 PS00134 Serine proteases, trypsin family, histidine active site. 862908006644 Signal peptide predicted for BMS1775 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.857 between residues 21 and 22 862908006645 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908006646 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862908006647 PS00134 Serine proteases, trypsin family, histidine active site. 862908006648 Signal peptide predicted for BMS1777 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.789 between residues 22 and 23 862908006649 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862908006650 substrate binding pocket [chemical binding]; other site 862908006651 inhibitor binding site; inhibition site 862908006652 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 1.5e-16 862908006653 FtsH Extracellular; Region: FtsH_ext; pfam06480 862908006654 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862908006655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908006656 Walker A motif; other site 862908006657 ATP binding site [chemical binding]; other site 862908006658 Walker B motif; other site 862908006659 arginine finger; other site 862908006660 Peptidase family M41; Region: Peptidase_M41; pfam01434 862908006661 HMMPfam hit to PF01434, Peptidase M41, score 1.7e-103 862908006662 HMMPfam hit to PF00004, AAA ATPase, central region, score 2e-95 862908006663 PS00674 AAA-protein family signature. 862908006664 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006665 HMMPfam hit to PF06480, Peptidase M41, FtsH extracellular, score 3.5e-26 862908006666 2 probable transmembrane helices predicted for BMS1779 by TMHMM2.0 at aa 7-24 and 105-127 862908006667 Signal peptide predicted for BMS1779 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.554 between residues 26 and 27 862908006668 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 862908006669 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 862908006670 Ligand Binding Site [chemical binding]; other site 862908006671 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006672 HMMPfam hit to PF01171, PP-loop, score 6.1e-52 862908006673 2 probable transmembrane helices predicted for BMS1781 by TMHMM2.0 at aa 7-29 and 39-61 862908006674 Predicted transcriptional regulator [Transcription]; Region: COG4190 862908006675 Signal peptide predicted for BMS1786 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 18 and 19 862908006676 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862908006677 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 862908006678 putative ligand binding site [chemical binding]; other site 862908006679 NAD binding site [chemical binding]; other site 862908006680 dimer interface [polypeptide binding]; other site 862908006681 putative catalytic site [active] 862908006682 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.6e-25 862908006683 4 probable transmembrane helices predicted for BMS1788 by TMHMM2.0 at aa 7-29, 42-64, 77-99 and 104-126 862908006684 Signal peptide predicted for BMS1788 by SignalP 2.0 HMM (Signal peptide probability 0.631) with cleavage site probability 0.347 between residues 29 and 30 862908006685 Signal peptide predicted for BMS1789 by SignalP 2.0 HMM (Signal peptide probability 0.812) with cleavage site probability 0.403 between residues 31 and 32 862908006686 ASCH domain; Region: ASCH; pfam04266 862908006687 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 862908006688 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 862908006689 putative NAD(P) binding site [chemical binding]; other site 862908006690 putative substrate binding site [chemical binding]; other site 862908006691 catalytic Zn binding site [ion binding]; other site 862908006692 structural Zn binding site [ion binding]; other site 862908006693 dimer interface [polypeptide binding]; other site 862908006694 HMMPfam hit to PF00107, Zinc-containing alcohol dehydrogenase superfamily, score 7.9e-94 862908006695 PS00059 Zinc-containing alcohol dehydrogenases signature. 862908006696 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908006697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908006698 salt bridge; other site 862908006699 non-specific DNA binding site [nucleotide binding]; other site 862908006700 sequence-specific DNA binding site [nucleotide binding]; other site 862908006701 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 862908006702 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862908006703 Catalytic site [active] 862908006704 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, score 1.8e-14 862908006705 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 862908006706 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 862908006707 active site 862908006708 DNA binding site [nucleotide binding] 862908006709 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 862908006710 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 6.1e-98 862908006711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 862908006712 active site 862908006713 motif I; other site 862908006714 motif II; other site 862908006715 Signal peptide predicted for BMS1798 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.385 between residues 29 and 30 862908006716 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 862908006717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862908006718 catalytic loop [active] 862908006719 iron binding site [ion binding]; other site 862908006720 HMMPfam hit to PF00111, Ferredoxin, score 2.1e-11 862908006721 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 862908006722 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862908006723 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862908006724 [2Fe-2S] cluster binding site [ion binding]; other site 862908006725 HMMPfam hit to PF00355, Rieske [2Fe-2S] region, score 1.7e-22 862908006726 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 862908006727 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 862908006728 4 probable transmembrane helices predicted for BMS1802 by TMHMM2.0 at aa 5-21, 41-63, 73-95 and 128-147 862908006729 2 probable transmembrane helices predicted for BMS1804 by TMHMM2.0 at aa 7-29 and 68-90 862908006730 GH3 auxin-responsive promoter; Region: GH3; pfam03321 862908006731 HMMPfam hit to PF03321, GH3 auxin-responsive promoter, score 5.6e-12 862908006732 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862908006733 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862908006734 iron-sulfur cluster [ion binding]; other site 862908006735 [2Fe-2S] cluster binding site [ion binding]; other site 862908006736 HMMPfam hit to PF00355, Rieske [2Fe-2S] region, score 2.1e-21 862908006737 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 862908006738 dinuclear metal binding motif [ion binding]; other site 862908006739 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862908006740 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862908006741 [2Fe-2S] cluster binding site [ion binding]; other site 862908006742 HMMPfam hit to PF00355, Rieske [2Fe-2S] region, score 2.9e-25 862908006743 Signal peptide predicted for BMS1810 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 24 and 25 862908006744 Signal peptide predicted for BMS1811 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.620 between residues 23 and 24 862908006745 PS00588 Flagella basal body rod proteins signature. 862908006746 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 862908006747 Signal peptide predicted for BMS1812 by SignalP 2.0 HMM (Signal peptide probability 0.616) with cleavage site probability 0.281 between residues 22 and 23 862908006748 HMMPfam hit to PF00050, Proteinase inhibitor I1, Kazal, score 0.001 862908006749 HMMPfam hit to PF07648, Protease inhibitor, Kazal-type, score 5.1e-07 862908006750 PS00282 Kazal serine protease inhibitors family signature. 862908006751 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862908006752 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 862908006753 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 862908006754 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 862908006755 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 862908006756 RNA binding site [nucleotide binding]; other site 862908006757 HMMPfam hit to PF00575, RNA binding S1, score 1.3e-23 862908006758 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 862908006759 Signal peptide predicted for BMS1815 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.856 between residues 28 and 29 862908006760 9 probable transmembrane helices predicted for BMS1815 by TMHMM2.0 at aa 7-26, 82-104, 117-136, 175-197, 204-226, 267-285, 292-314, 334-356 and 633-652 862908006761 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 862908006762 Signal peptide predicted for BMS1817 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.694 between residues 27 and 28 862908006763 Signal peptide predicted for BMS1818 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 20 and 21 862908006764 Signal peptide predicted for BMS1819 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 862908006765 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 862908006766 4 probable transmembrane helices predicted for BMS1820 by TMHMM2.0 at aa 21-43, 254-276, 302-324 and 352-374 862908006767 Signal peptide predicted for BMS1820 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.250 between residues 41 and 42 862908006768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908006769 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 862908006770 substrate binding site [chemical binding]; other site 862908006771 oxyanion hole (OAH) forming residues; other site 862908006772 trimer interface [polypeptide binding]; other site 862908006773 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862908006774 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862908006775 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1.2e-38 862908006776 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 862908006777 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 1.2e-68 862908006778 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 6e-50 862908006779 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 862908006780 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862908006781 dimer interface [polypeptide binding]; other site 862908006782 active site 862908006783 HMMPfam hit to PF02803, Thiolase, score 8.6e-59 862908006784 PS00099 Thiolases active site. 862908006785 PS00737 Thiolases signature 2. 862908006786 HMMPfam hit to PF00108, Thiolase, score 5.4e-75 862908006787 Signal peptide predicted for BMS1824 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.799 between residues 25 and 26 862908006788 1 probable transmembrane helix predicted for BMS1825 by TMHMM2.0 at aa 13-30 862908006789 PS00134 Serine proteases, trypsin family, histidine active site. 862908006790 1 probable transmembrane helix predicted for BMS1827 by TMHMM2.0 at aa 12-34 862908006791 Signal peptide predicted for BMS1828 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.860 between residues 30 and 31 862908006792 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 862908006793 thymidylate kinase; Validated; Region: tmk; PRK00698 862908006794 TMP-binding site; other site 862908006795 ATP-binding site [chemical binding]; other site 862908006796 HMMPfam hit to PF02223, Thymidylate kinase, score 2.5e-47 862908006797 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006798 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 862908006799 PSP1 C-terminal conserved region; Region: PSP1; cl00770 862908006800 HMMPfam hit to PF04468, PSP1 C-terminal conserved region, score 2.9e-23 862908006801 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 862908006802 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 862908006803 active site 862908006804 metal binding site [ion binding]; metal-binding site 862908006805 DNA binding site [nucleotide binding] 862908006806 HMMPfam hit to PF00149, Metallophosphoesterase, score 1e-18 862908006807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908006808 AAA domain; Region: AAA_23; pfam13476 862908006809 Walker A/P-loop; other site 862908006810 ATP binding site [chemical binding]; other site 862908006811 Q-loop/lid; other site 862908006812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908006813 ABC transporter signature motif; other site 862908006814 Walker B; other site 862908006815 D-loop; other site 862908006816 H-loop/switch region; other site 862908006817 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006818 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 862908006819 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 862908006820 putative dimer interface [polypeptide binding]; other site 862908006821 putative anticodon binding site; other site 862908006822 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 862908006823 homodimer interface [polypeptide binding]; other site 862908006824 motif 1; other site 862908006825 motif 2; other site 862908006826 active site 862908006827 motif 3; other site 862908006828 HMMPfam hit to PF00152, tRNA synthetase, class II (D, K and N), score 3.1e-127 862908006829 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908006830 HMMPfam hit to PF01336, OB-fold nucleic acid binding, score 4.9e-18 862908006831 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 862908006832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862908006833 substrate binding site [chemical binding]; other site 862908006834 ATP binding site [chemical binding]; other site 862908006835 HMMPfam hit to PF00294, Carbohydrate kinase, PfkB, score 7.6e-44 862908006836 PS00584 pfkB family of carbohydrate kinases signature 2. 862908006837 HMMPfam hit to PF06392, Acid shock, score 90 862908006838 HMMPfam hit to PF06392, Acid shock, score 14 862908006839 Uncharacterized conserved protein [Function unknown]; Region: COG2353 862908006840 Signal peptide predicted for BMS1838 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.648 between residues 18 and 19 862908006841 HMMPfam hit to PF04264, YceI, score 2.1e-50 862908006842 2 probable transmembrane helices predicted for BMS1838 by TMHMM2.0 at aa 251-270 and 291-313 862908006843 hypothetical protein; Validated; Region: PRK02101 862908006844 HMMPfam hit to PF03883, Protein of unknown function DUF328, score 2.3e-114 862908006845 PilZ domain; Region: PilZ; pfam07238 862908006846 2 probable transmembrane helices predicted for BMS1841 by TMHMM2.0 at aa 20-42 and 68-87 862908006847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908006848 S-adenosylmethionine binding site [chemical binding]; other site 862908006849 HMMPfam hit to PF04445, Protein of unknown function DUF548, score 1.4e-20 862908006850 glycine dehydrogenase; Provisional; Region: PRK05367 862908006851 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908006852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908006853 catalytic residue [active] 862908006854 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908006855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908006856 catalytic residue [active] 862908006857 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 3.5e-21 862908006858 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006859 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 862908006860 Family of unknown function (DUF633); Region: DUF633; pfam04816 862908006861 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 862908006862 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 862908006863 active site 862908006864 metal binding site [ion binding]; metal-binding site 862908006865 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862908006866 HMMPfam hit to PF00149, Metallophosphoesterase, score 8.3e-19 862908006867 Signal peptide predicted for BMS1845 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.824 between residues 18 and 19 862908006868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 862908006869 Peptidase family M48; Region: Peptidase_M48; cl12018 862908006870 Signal peptide predicted for BMS1847 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 862908006871 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908006872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 862908006873 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862908006874 Signal peptide predicted for BMS1849 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 24 and 25 862908006875 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 862908006876 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 862908006877 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 862908006878 HMMPfam hit to PF00254, Peptidylprolyl isomerase, FKBP-type, score 8.3e-45 862908006879 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 862908006880 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 862908006881 Signal peptide predicted for BMS1850 by SignalP 2.0 HMM (Signal peptide probability 0.825) with cleavage site probability 0.355 between residues 18 and 19 862908006882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908006883 active site 862908006884 motif I; other site 862908006885 motif II; other site 862908006886 HMMPfam hit to PF03767, Acid phosphatase (Class B), score 2e-52 862908006887 Signal peptide predicted for BMS1851 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.616 between residues 20 and 21 862908006888 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908006889 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 862908006890 RNA/DNA hybrid binding site [nucleotide binding]; other site 862908006891 active site 862908006892 HMMPfam hit to PF00075, RNase H, score 8.4e-38 862908006893 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908006894 active site 862908006895 Zn binding site [ion binding]; other site 862908006896 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 5.2e-15 862908006897 Signal peptide predicted for BMS1854 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.913 between residues 22 and 23 862908006898 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908006899 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908006900 active site 862908006901 Signal peptide predicted for BMS1855 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.721 between residues 21 and 22 862908006902 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908006903 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 862908006904 HMMPfam hit to PF01258, Zn-finger, prokaryotic DksA/TraR C4 type, score 5.2e-07 862908006905 Signal peptide predicted for BMS1857 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.379 between residues 37 and 38 862908006906 1 probable transmembrane helix predicted for BMS1857 by TMHMM2.0 at aa 12-34 862908006907 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 862908006908 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 862908006909 RNA binding site [nucleotide binding]; other site 862908006910 active site 862908006911 HMMPfam hit to PF01509, Pseudouridylate synthase TruB, N-terminal, score 2.9e-29 862908006912 Ribosome-binding factor A; Region: RBFA; pfam02033 862908006913 HMMPfam hit to PF02033, Ribosome-binding factor A, score 9.5e-07 862908006914 PS01319 Ribosome-binding factor A signature. 862908006915 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 862908006916 translation initiation factor IF-2; Region: IF-2; TIGR00487 862908006917 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 862908006918 G1 box; other site 862908006919 putative GEF interaction site [polypeptide binding]; other site 862908006920 GTP/Mg2+ binding site [chemical binding]; other site 862908006921 Switch I region; other site 862908006922 G2 box; other site 862908006923 G3 box; other site 862908006924 Switch II region; other site 862908006925 G4 box; other site 862908006926 G5 box; other site 862908006927 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 862908006928 Translation-initiation factor 2; Region: IF-2; pfam11987 862908006929 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 862908006930 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 9.7e-08 862908006931 PS01176 Initiation factor 2 signature. 862908006932 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 6.3e-09 862908006933 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.1e-47 862908006934 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 9.7e-09 862908006935 PS00017 ATP/GTP-binding site motif A (P-loop). 862908006936 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 9.7e-06 862908006937 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 862908006938 NusA N-terminal domain; Region: NusA_N; pfam08529 862908006939 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 862908006940 RNA binding site [nucleotide binding]; other site 862908006941 homodimer interface [polypeptide binding]; other site 862908006942 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 862908006943 G-X-X-G motif; other site 862908006944 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 862908006945 G-X-X-G motif; other site 862908006946 HMMPfam hit to PF00575, RNA binding S1, score 4.9e-07 862908006947 ribosome maturation protein RimP; Reviewed; Region: PRK00092 862908006948 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 862908006949 putative oligomer interface [polypeptide binding]; other site 862908006950 putative RNA binding site [nucleotide binding]; other site 862908006951 HMMPfam hit to PF02576, Protein of unknown function DUF150, score 2.4e-23 862908006952 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 862908006953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908006954 Coenzyme A binding pocket [chemical binding]; other site 862908006955 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.4e-10 862908006956 Signal peptide predicted for BMS1864 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.960 between residues 18 and 19 862908006957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908006958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862908006959 binding surface 862908006960 TPR motif; other site 862908006961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908006962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 862908006963 DNA binding site [nucleotide binding] 862908006964 HMMPfam hit to PF00515, TPR repeat, score 0.027 862908006965 HMMPfam hit to PF07719, , score 0.066; PF07719, Tetratricopeptide repeat 862908006966 HMMPfam hit to PF07719, , score 2; PF07719, Tetratricopeptide repeat 862908006967 HMMPfam hit to PF00515, TPR repeat, score 0.18 862908006968 HMMPfam hit to PF00515, TPR repeat, score 0.052; HMMPfam hit to PF07719, , score 0.094; PF07719, Tetratricopeptide repeat 862908006969 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 862908006970 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 862908006971 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 862908006972 active site 862908006973 dimer interface [polypeptide binding]; other site 862908006974 motif 1; other site 862908006975 motif 2; other site 862908006976 motif 3; other site 862908006977 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 862908006978 anticodon binding site; other site 862908006979 HMMPfam hit to PF00587, tRNA synthetases, class-II (G, H, P and S), score 1.1e-38 862908006980 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908006981 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908006982 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908006983 HMMPfam hit to PF03129, Anticodon-binding, score 1.3e-28 862908006984 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 862908006985 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 862908006986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908006987 PS00697 ATP-dependent DNA ligase AMP-binding site. 862908006988 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 1.4e-63 862908006989 L-lysine aminotransferase; Provisional; Region: PRK08297 862908006990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908006991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908006992 catalytic residue [active] 862908006993 HMMPfam hit to PF00202, Aminotransferase class-III, score 9.4e-13 862908006994 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 862908006995 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 862908006996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908006997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908006998 catalytic residue [active] 862908006999 HMMPfam hit to PF00202, Aminotransferase class-III, score 9.7e-48 862908007000 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 862908007001 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 862908007002 HMMPfam hit to PF01144, Coenzyme A transferase, score 1.7e-77 862908007003 Coenzyme A transferase; Region: CoA_trans; cl17247 862908007004 HMMPfam hit to PF01144, Coenzyme A transferase, score 2.1e-40 862908007005 Signal peptide predicted for BMS1874 by SignalP 2.0 HMM (Signal peptide probability 0.799) with cleavage site probability 0.722 between residues 30 and 31 862908007006 NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit; Region: nqrF; TIGR01941 862908007007 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908007008 putative catalytic site [active] 862908007009 putative metal binding site [ion binding]; other site 862908007010 putative phosphate binding site [ion binding]; other site 862908007011 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862908007012 active site 862908007013 catalytic site [active] 862908007014 substrate binding site [chemical binding]; other site 862908007015 HMMPfam hit to PF00929, Exonuclease, score 0.00083 862908007016 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908007017 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908007018 HMMPfam hit to PF01551, Peptidase M23B, score 1.6e-41 862908007019 Signal peptide predicted for BMS1878 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.539 between residues 23 and 24 862908007020 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 862908007021 HMMPfam hit to PF01975, Survival protein SurE, score 4.7e-66 862908007022 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 862908007023 Glutamine amidotransferase class-I; Region: GATase; pfam00117 862908007024 glutamine binding [chemical binding]; other site 862908007025 catalytic triad [active] 862908007026 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.3e-12 862908007027 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 862908007028 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007029 Signal peptide predicted for BMS1882 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908007030 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 862908007031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908007032 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 862908007033 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 862908007034 Signal peptide predicted for BMS1886 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 40 and 41 862908007035 1 probable transmembrane helix predicted for BMS1886 by TMHMM2.0 at aa 12-34 862908007036 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 862908007037 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.8e-07 862908007038 GAF domain; Region: GAF; cl17456 862908007039 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908007040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908007041 Zn2+ binding site [ion binding]; other site 862908007042 Mg2+ binding site [ion binding]; other site 862908007043 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 3.5e-32 862908007044 HMMPfam hit to PF01590, GAF, score 2e-08 862908007045 Predicted methyltransferases [General function prediction only]; Region: COG0313 862908007046 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 862908007047 putative SAM binding site [chemical binding]; other site 862908007048 putative homodimer interface [polypeptide binding]; other site 862908007049 HMMPfam hit to PF00590, Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase, score 9.5e-22 862908007050 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862908007051 anti sigma factor interaction site; other site 862908007052 regulatory phosphorylation site [posttranslational modification]; other site 862908007053 HMMPfam hit to PF01740, Sulfate transporter/antisigma-factor antagonist STAS, score 6.5e-10 862908007054 2 probable transmembrane helices predicted for BMS1891 by TMHMM2.0 at aa 48-70 and 75-97 862908007055 Signal peptide predicted for BMS1891 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.938 between residues 40 and 41 862908007056 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 862908007057 RNA/DNA hybrid binding site [nucleotide binding]; other site 862908007058 active site 862908007059 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 1e-41 862908007060 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 862908007061 HMMPfam hit to PF01245, Ribosomal protein L19, score 8.7e-47 862908007062 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 862908007063 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 862908007064 HMMPfam hit to PF01746, tRNA (guanine-N1-)-methyltransferase, score 2.8e-65 862908007065 PS00211 ABC transporters family signature. 862908007066 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 862908007067 RimM N-terminal domain; Region: RimM; pfam01782 862908007068 PRC-barrel domain; Region: PRC; pfam05239 862908007069 HMMPfam hit to PF05239, PRC-barrel, score 1.5e-10 862908007070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862908007071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 862908007072 active site 862908007073 metal binding site [ion binding]; metal-binding site 862908007074 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 2e-07 862908007075 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 862908007076 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 862908007077 putative tRNA-binding site [nucleotide binding]; other site 862908007078 B3/4 domain; Region: B3_4; pfam03483 862908007079 tRNA synthetase B5 domain; Region: B5; smart00874 862908007080 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862908007081 motif 1; other site 862908007082 dimer interface [polypeptide binding]; other site 862908007083 active site 862908007084 motif 2; other site 862908007085 motif 3; other site 862908007086 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 862908007087 HMMPfam hit to PF03147, Ferredoxin-fold anticodon-binding, score 9.7e-10 862908007088 HMMPfam hit to PF03484, tRNA synthetase, B5, score 1.9e-20 862908007089 HMMPfam hit to PF03483, B3/4, score 5e-76 862908007090 HMMPfam hit to PF01588, t-RNA-binding region, score 1.5e-29 862908007091 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 862908007092 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 862908007093 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 862908007094 dimer interface [polypeptide binding]; other site 862908007095 motif 1; other site 862908007096 active site 862908007097 motif 2; other site 862908007098 motif 3; other site 862908007099 HMMPfam hit to PF01409, Phenylalanyl-tRNA synthetase, class IIc, score 1.4e-121 862908007100 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908007101 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 862908007102 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908007103 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase, class II, N-terminal, score 5.1e-16 862908007104 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 862908007105 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862908007106 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 862908007107 putative ribose interaction site [chemical binding]; other site 862908007108 putative ADP binding site [chemical binding]; other site 862908007109 HMMPfam hit to PF00294, Carbohydrate kinase, PfkB, score 1.9e-19 862908007110 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862908007111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908007112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908007113 cytidylate kinase; Provisional; Region: cmk; PRK00023 862908007114 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 862908007115 CMP-binding site; other site 862908007116 The sites determining sugar specificity; other site 862908007117 HMMPfam hit to PF02224, Cytidylate kinase, score 3.4e-50 862908007118 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007119 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862908007120 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908007121 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908007122 catalytic residue [active] 862908007123 HMMPfam hit to PF01464, SLT, score 5.6e-22 862908007124 1 probable transmembrane helix predicted for BMS1908 by TMHMM2.0 at aa 20-37 862908007125 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 862908007126 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 862908007127 catalytic residues [active] 862908007128 HMMPfam hit to PF03190, Protein of unknown function DUF255, score 6.2e-39 862908007129 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 862908007130 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862908007131 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862908007132 1 probable transmembrane helix predicted for BMS1911 by TMHMM2.0 at aa 22-44 862908007133 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 862908007134 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 862908007135 HMMPfam hit to PF00254, Peptidylprolyl isomerase, FKBP-type, score 0.0008 862908007136 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 862908007137 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 862908007138 active site 862908007139 dimer interface [polypeptide binding]; other site 862908007140 Signal peptide predicted for BMS1913 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.545 between residues 21 and 22 862908007141 HMMPfam hit to PF00245, Alkaline phosphatase, score 3.5e-40 862908007142 PS00123 Alkaline phosphatase active site. 862908007143 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908007144 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908007145 HMMPfam hit to PF01551, Peptidase M23B, score 1e-36 862908007146 Signal peptide predicted for BMS1914 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.863 between residues 21 and 22 862908007147 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 862908007148 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 862908007149 Ligand Binding Site [chemical binding]; other site 862908007150 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 4.2e-187 862908007151 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 862908007152 Peptidase family M28; Region: Peptidase_M28; pfam04389 862908007153 metal binding site [ion binding]; metal-binding site 862908007154 HMMPfam hit to PF04389, Peptidase M28, score 1.9e-13 862908007155 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 862908007156 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 862908007157 Ligand Binding Site [chemical binding]; other site 862908007158 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 862908007159 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 862908007160 cofactor binding site; other site 862908007161 DNA binding site [nucleotide binding] 862908007162 substrate interaction site [chemical binding]; other site 862908007163 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 862908007164 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 2.3e-76 862908007165 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 862908007166 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 862908007167 nucleotide binding site [chemical binding]; other site 862908007168 Signal peptide predicted for BMS1920 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.446 between residues 25 and 26 862908007169 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 3e-06 862908007170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862908007171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908007172 Signal peptide predicted for BMS1921 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.864 between residues 19 and 20 862908007173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007174 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 2.2e-21 862908007175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908007176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908007178 Walker A/P-loop; other site 862908007179 ATP binding site [chemical binding]; other site 862908007180 Q-loop/lid; other site 862908007181 ABC transporter signature motif; other site 862908007182 Walker B; other site 862908007183 D-loop; other site 862908007184 H-loop/switch region; other site 862908007185 HMMPfam hit to PF00005, ABC transporter, score 4.1e-44 862908007186 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007187 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 3.6e-28 862908007188 5 probable transmembrane helices predicted for BMS1922 by TMHMM2.0 at aa 42-64, 79-98, 160-177, 181-198 and 268-290 862908007189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908007190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908007191 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 862908007192 Walker A/P-loop; other site 862908007193 ATP binding site [chemical binding]; other site 862908007194 Q-loop/lid; other site 862908007195 ABC transporter signature motif; other site 862908007196 Walker B; other site 862908007197 D-loop; other site 862908007198 H-loop/switch region; other site 862908007199 HMMPfam hit to PF00005, ABC transporter, score 3.8e-43 862908007200 PS00211 ABC transporters family signature. 862908007201 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007202 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 0.00015 862908007203 4 probable transmembrane helices predicted for BMS1923 by TMHMM2.0 at aa 21-43, 68-90, 143-165 and 258-280 862908007204 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 862908007205 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 862908007206 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 862908007207 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1.8e-30 862908007208 Pectinacetylesterase; Region: PAE; pfam03283 862908007209 Signal peptide predicted for BMS1925 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.920 between residues 17 and 18 862908007210 Signal peptide predicted for BMS1926 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.554 between residues 24 and 25 862908007211 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 862908007212 Signal peptide predicted for BMS1927 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 32 and 33 862908007213 1 probable transmembrane helix predicted for BMS1927 by TMHMM2.0 at aa 15-33 862908007214 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 862908007215 Transglycosylase; Region: Transgly; pfam00912 862908007216 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 9e-51 862908007217 1 probable transmembrane helix predicted for BMS1930 by TMHMM2.0 at aa 9-31 862908007218 Signal peptide predicted for BMS1930 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.451 between residues 21 and 22 862908007219 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862908007220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908007221 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cl11615 862908007222 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862908007223 PS00221 MIP family signature. 862908007224 Signal peptide predicted for BMS1932 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.917 between residues 21 and 22 862908007225 Signal peptide predicted for BMS1934 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.774 between residues 19 and 20 862908007226 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 862908007227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908007228 active site 862908007229 motif I; other site 862908007230 motif II; other site 862908007231 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 862908007232 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862908007233 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 862908007234 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 2.7e-31 862908007235 PS00097 Aspartate and ornithine carbamoyltransferases signature. 862908007236 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 4e-13 862908007237 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 862908007238 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 862908007239 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 862908007240 catalytic site [active] 862908007241 subunit interface [polypeptide binding]; other site 862908007242 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 862908007243 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862908007244 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908007245 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 862908007246 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862908007247 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908007248 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 862908007249 IMP binding site; other site 862908007250 dimer interface [polypeptide binding]; other site 862908007251 interdomain contacts; other site 862908007252 partial ornithine binding site; other site 862908007253 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase, small chain, score 2.7e-13 862908007254 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.1e-38 862908007255 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 2.5e-43 862908007256 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 2.4e-79 862908007257 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 862908007258 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large chain, oligomerisation, score 1.2e-37 862908007259 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 7.9e-13 862908007260 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 8.7e-12 862908007261 HMMPfam hit to PF02142, Methylglyoxal synthase-like, score 1.9e-19 862908007262 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 862908007263 active site 862908007264 dimer interface [polypeptide binding]; other site 862908007265 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, score 5.4e-39 862908007266 PS00156 Orotidine 5'-phosphate decarboxylase active site. 862908007267 Signal peptide predicted for BMS1941 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.972 between residues 18 and 19 862908007268 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 862908007269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862908007270 substrate binding site [chemical binding]; other site 862908007271 ATP binding site [chemical binding]; other site 862908007272 HMMPfam hit to PF00294, Carbohydrate kinase, PfkB, score 5.2e-08 862908007273 PS00584 pfkB family of carbohydrate kinases signature 2. 862908007274 Signal peptide predicted for BMS1943 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.956 between residues 32 and 33 862908007275 1 probable transmembrane helix predicted for BMS1943 by TMHMM2.0 at aa 9-31 862908007276 1 probable transmembrane helix predicted for BMS1944 by TMHMM2.0 at aa 5-27 862908007277 Signal peptide predicted for BMS1944 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.504 between residues 21 and 22 862908007278 Signal peptide predicted for BMS1945 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.480 between residues 16 and 17 862908007279 1 probable transmembrane helix predicted for BMS1946 by TMHMM2.0 at aa 115-137 862908007280 Signal peptide predicted for BMS1947 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.995 between residues 19 and 20 862908007281 Signal peptide predicted for BMS1949 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.890 between residues 22 and 23 862908007282 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 862908007283 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 862908007284 MgtC family; Region: MgtC; pfam02308 862908007285 HMMPfam hit to PF02308, MgtC/SapB transporter, score 2e-39 862908007286 5 probable transmembrane helices predicted for BMS1951 by TMHMM2.0 at aa 15-37, 50-69, 79-96, 103-125 and 129-151 862908007287 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 862908007288 2 probable transmembrane helices predicted for BMS1953 by TMHMM2.0 at aa 15-34 and 55-72 862908007289 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862908007290 active site 862908007291 Signal peptide predicted for BMS1956 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908007292 Propeptide_C25; Region: Propeptide_C25; pfam08126 862908007293 Peptidase family C25; Region: Peptidase_C25; pfam01364 862908007294 active site 862908007295 1 probable transmembrane helix predicted for BMS1958 by TMHMM2.0 at aa 7-29 862908007296 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 862908007297 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 862908007298 Signal peptide predicted for BMS1959 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.704 between residues 34 and 35 862908007299 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007300 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 862908007301 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 862908007302 Walker A/P-loop; other site 862908007303 ATP binding site [chemical binding]; other site 862908007304 Q-loop/lid; other site 862908007305 ABC transporter signature motif; other site 862908007306 Walker B; other site 862908007307 D-loop; other site 862908007308 H-loop/switch region; other site 862908007309 HMMPfam hit to PF00005, ABC transporter, score 5.8e-58 862908007310 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007311 PS00211 ABC transporters family signature. 862908007312 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 862908007313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862908007314 8 probable transmembrane helices predicted for BMS1961 by TMHMM2.0 at aa 32-54, 64-86, 107-129, 167-189, 218-240, 275-293, 300-322 and 332-351 862908007315 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.7e-10 862908007316 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908007317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908007318 substrate binding pocket [chemical binding]; other site 862908007319 membrane-bound complex binding site; other site 862908007320 hinge residues; other site 862908007321 Signal peptide predicted for BMS1962 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 862908007322 Signal peptide predicted for BMS1963 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.597 between residues 23 and 24 862908007323 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908007324 HMMPfam hit to PF00873, Acriflavin resistance protein, score 6.2e-40 862908007325 11 probable transmembrane helices predicted for BMS1964 by TMHMM2.0 at aa 15-37, 339-361, 394-416, 437-456, 466-488, 521-543, 866-885, 892-911, 921-943, 964-986 and 996-1018 862908007326 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 862908007327 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 862908007328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862908007329 competence/damage-inducible protein CinA N-terminal domain; Region: cinA_nterm; TIGR00200 862908007330 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 862908007331 putative MPT binding site; other site 862908007332 Competence-damaged protein; Region: CinA; pfam02464 862908007333 HMMPfam hit to PF00994, Molybdenum cofactor biosynthesis protein, score 6.9e-07 862908007334 PS00213 Lipocalin signature. 862908007335 HMMPfam hit to PF02464, CinA, C-terminal, score 3.4e-53 862908007336 Signal peptide predicted for BMS1967 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 18 and 19 862908007337 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007338 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007339 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007340 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007341 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007342 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007343 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007344 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007345 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007346 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007347 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007348 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007349 FG-GAP repeat; Region: FG-GAP_2; pfam14312 862908007350 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007351 Protein of unknown function, DUF547; Region: DUF547; pfam04784 862908007352 Signal peptide predicted for BMS1970 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.519 between residues 28 and 29 862908007353 Bacitracin resistance protein BacA; Region: BacA; pfam02673 862908007354 6 probable transmembrane helices predicted for BMS1971 by TMHMM2.0 at aa 87-104, 117-134, 149-168, 188-205, 220-242 and 249-267 862908007355 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 2.1e-76 862908007356 2 probable transmembrane helices predicted for BMS1972 by TMHMM2.0 at aa 10-32 and 149-171 862908007357 Signal peptide predicted for BMS1974 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.610 between residues 36 and 37 862908007358 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 862908007359 Zn binding site [ion binding]; other site 862908007360 Signal peptide predicted for BMS1975 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.825 between residues 39 and 40 862908007361 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908007362 PS00190 Cytochrome c family heme-binding site signature. 862908007363 1 probable transmembrane helix predicted for BMS1976 by TMHMM2.0 at aa 6-25 862908007364 1 probable transmembrane helix predicted for BMS1977 by TMHMM2.0 at aa 7-29 862908007365 Signal peptide predicted for BMS1977 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 862908007366 Signal peptide predicted for BMS1978 by SignalP 2.0 HMM (Signal peptide probability 0.615) with cleavage site probability 0.210 between residues 17 and 18 862908007367 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908007368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 862908007369 substrate binding pocket [chemical binding]; other site 862908007370 membrane-bound complex binding site; other site 862908007371 hinge residues; other site 862908007372 Signal peptide predicted for BMS1979 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.778 between residues 19 and 20 862908007373 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 862908007374 active site 862908007375 catalytic residues [active] 862908007376 Signal peptide predicted for BMS1980 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 19 and 20 862908007377 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 862908007378 HMMPfam hit to PF01144, Coenzyme A transferase, score 5.2e-59 862908007379 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 862908007380 PS01274 CoA transferases signature 2. 862908007381 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 862908007382 HMMPfam hit to PF01144, Coenzyme A transferase, score 2.2e-90 862908007383 this CDS contains a stop codon after residue 297 862908007384 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 3.7e-65 862908007385 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 1.8e-87 862908007386 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 862908007387 Part of AAA domain; Region: AAA_19; pfam13245 862908007388 Family description; Region: UvrD_C_2; pfam13538 862908007389 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.8e-182 862908007390 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007391 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 862908007392 Signal peptide predicted for BMS1988 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.603 between residues 18 and 19 862908007393 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007394 enoyl-CoA hydratase; Provisional; Region: PRK09245 862908007395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908007396 substrate binding site [chemical binding]; other site 862908007397 oxyanion hole (OAH) forming residues; other site 862908007398 trimer interface [polypeptide binding]; other site 862908007399 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 1.7e-44 862908007400 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007401 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 862908007402 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 862908007403 active site 862908007404 catalytic residues [active] 862908007405 metal binding site [ion binding]; metal-binding site 862908007406 HMMPfam hit to PF00682, HMG-CoA lyase-like, score 1e-69 862908007407 this CDS contains a framshift after residue 497 862908007408 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 1.8e-20 862908007409 PS00188 Biotin-requiring enzymes attachment site. 862908007410 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 1.1e-41 862908007411 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.1e-95 862908007412 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 862908007413 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 862908007414 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 5.7e-41 862908007415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908007416 enoyl-CoA hydratase; Provisional; Region: PRK05995 862908007417 substrate binding site [chemical binding]; other site 862908007418 oxyanion hole (OAH) forming residues; other site 862908007419 trimer interface [polypeptide binding]; other site 862908007420 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 3.3e-42 862908007421 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 862908007422 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 862908007423 HMMPfam hit to PF01039, Carboxyl transferase, score 2.3e-212 862908007424 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007425 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007426 Signal peptide predicted for BMS1996 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.876 between residues 18 and 19 862908007427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 862908007428 nudix motif; other site 862908007429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862908007430 HMMPfam hit to PF00753, Beta-lactamase-like, score 6.9e-18 862908007431 HMMPfam hit to PF00293, NUDIX hydrolase, score 1e-06 862908007432 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 862908007433 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862908007434 dimer interface [polypeptide binding]; other site 862908007435 PYR/PP interface [polypeptide binding]; other site 862908007436 TPP binding site [chemical binding]; other site 862908007437 substrate binding site [chemical binding]; other site 862908007438 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862908007439 TPP-binding site [chemical binding]; other site 862908007440 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 862908007441 HMMPfam hit to PF02775, Pyruvate decarboxylase, score 6.9e-20 862908007442 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 862908007443 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 862908007444 dimer interface [polypeptide binding]; other site 862908007445 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 862908007446 active site 862908007447 Fe binding site [ion binding]; other site 862908007448 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 3.9e-06 862908007449 enoyl-CoA hydratase; Provisional; Region: PRK05862 862908007450 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908007451 substrate binding site [chemical binding]; other site 862908007452 oxyanion hole (OAH) forming residues; other site 862908007453 trimer interface [polypeptide binding]; other site 862908007454 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 4.1e-65 862908007455 PS00166 Enoyl-CoA hydratase/isomerase signature. 862908007456 enoyl-CoA hydratase; Provisional; Region: PRK08140 862908007457 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908007458 substrate binding site [chemical binding]; other site 862908007459 oxyanion hole (OAH) forming residues; other site 862908007460 trimer interface [polypeptide binding]; other site 862908007461 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 2.1e-35 862908007462 1 probable transmembrane helix predicted for BMS2001 by TMHMM2.0 at aa 106-128 862908007463 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007464 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 862908007465 HMMPfam hit to PF05138, Phenylacetic acid catabolic, score 6.1e-12 862908007466 this CDS has a frameshift after residue 287 862908007467 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 7.6e-51 862908007468 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1.8e-39 862908007469 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 2.5e-09 862908007470 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 862908007471 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862908007472 dimer interface [polypeptide binding]; other site 862908007473 active site 862908007474 HMMPfam hit to PF00108, Thiolase, score 1.4e-100 862908007475 HMMPfam hit to PF02803, Thiolase, score 2.6e-59 862908007476 PS00737 Thiolases signature 2. 862908007477 PS00099 Thiolases active site. 862908007478 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 862908007479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908007480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908007481 Signal peptide predicted for BMS2006 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.975 between residues 19 and 20 862908007482 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.8e-41 862908007483 1 probable transmembrane helix predicted for BMS2006 by TMHMM2.0 at aa 364-386 862908007484 Signal peptide predicted for BMS2007 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.956 between residues 23 and 24 862908007485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007486 Signal peptide predicted for BMS2008 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.522 between residues 25 and 26 862908007487 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007488 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 862908007489 PQQ-like domain; Region: PQQ_2; pfam13360 862908007490 Trp docking motif [polypeptide binding]; other site 862908007491 active site 862908007492 Signal peptide predicted for BMS2009 by SignalP 2.0 HMM (Signal peptide probability 0.902) with cleavage site probability 0.418 between residues 20 and 21 862908007493 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 862908007495 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 862908007496 HMMPfam hit to PF07719, , score 0.16; PF07719, Tetratricopeptide repeat 862908007497 1 probable transmembrane helix predicted for BMS2010 by TMHMM2.0 at aa 29-51 862908007498 Signal peptide predicted for BMS2011 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.852 between residues 25 and 26 862908007499 Signal peptide predicted for BMS2012 by SignalP 2.0 HMM (Signal peptide probability 0.762) with cleavage site probability 0.388 between residues 23 and 24 862908007500 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 862908007501 Signal peptide predicted for BMS2013 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.968 between residues 17 and 18 862908007502 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 862908007503 G1 box; other site 862908007504 GTP/Mg2+ binding site [chemical binding]; other site 862908007505 Switch I region; other site 862908007506 G2 box; other site 862908007507 Switch II region; other site 862908007508 G3 box; other site 862908007509 G4 box; other site 862908007510 G5 box; other site 862908007511 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862908007512 G1 box; other site 862908007513 GTP/Mg2+ binding site [chemical binding]; other site 862908007514 G2 box; other site 862908007515 Switch I region; other site 862908007516 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862908007517 G3 box; other site 862908007518 Switch II region; other site 862908007519 GTP/Mg2+ binding site [chemical binding]; other site 862908007520 G4 box; other site 862908007521 G5 box; other site 862908007522 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2e-34 862908007523 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007524 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.4e-38 862908007525 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007526 GTPase Era; Reviewed; Region: era; PRK00089 862908007527 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 862908007528 G1 box; other site 862908007529 GTP/Mg2+ binding site [chemical binding]; other site 862908007530 Switch I region; other site 862908007531 G2 box; other site 862908007532 Switch II region; other site 862908007533 G3 box; other site 862908007534 G4 box; other site 862908007535 G5 box; other site 862908007536 KH domain; Region: KH_2; pfam07650 862908007537 HMMPfam hit to PF07650, KH, type 2, score 1.9e-16 862908007538 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 7.7e-29 862908007539 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007540 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 862908007541 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 862908007542 dimerization interface [polypeptide binding]; other site 862908007543 active site 862908007544 metal binding site [ion binding]; metal-binding site 862908007545 HMMPfam hit to PF00035, Double-stranded RNA binding, score 0.019 862908007546 HMMPfam hit to PF00636, Ribonuclease III, score 1.4e-38 862908007547 PS00517 Ribonuclease III family signature. 862908007548 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908007549 Signal peptide predicted for BMS2017 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.987 between residues 46 and 47 862908007550 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862908007551 active site 862908007552 Int/Topo IB signature motif; other site 862908007553 DNA binding site [nucleotide binding] 862908007554 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.7e-06 862908007555 HMMPfam hit to PF00589, Phage integrase, score 0.017 862908007556 Signal peptide predicted for BMS2019 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.600 between residues 23 and 24 862908007557 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 862908007558 active site 862908007559 intersubunit interactions; other site 862908007560 catalytic residue [active] 862908007561 HMMPfam hit to PF00923, Transaldolase, score 5.6e-65 862908007562 PS01054 Transaldolase signature 1. 862908007563 Signal peptide predicted for BMS2021 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.346 between residues 22 and 23 862908007564 HMMPfam hit to PF00413, Peptidase M10A and M12B, matrixin and adamalysin, score 0.00033 862908007565 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908007566 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 862908007567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908007568 DNA binding residues [nucleotide binding] 862908007569 HMMPfam hit to PF04542, Sigma-70 region 2, score 0.0017 862908007570 Protein of unknown function, DUF547; Region: DUF547; pfam04784 862908007571 Signal peptide predicted for BMS2024 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.627 between residues 17 and 18 862908007572 HMMPfam hit to PF04784, Protein of unknown function DUF547, score 1.2e-15 862908007573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908007574 FeS/SAM binding site; other site 862908007575 HMMPfam hit to PF04055, Radical SAM, score 8.1e-14 862908007576 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 862908007577 Signal peptide predicted for BMS2026 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 21 and 22 862908007578 PS00134 Serine proteases, trypsin family, histidine active site. 862908007579 Signal peptide predicted for BMS2028 by SignalP 2.0 HMM (Signal peptide probability 0.866) with cleavage site probability 0.857 between residues 27 and 28 862908007580 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 862908007581 23S rRNA binding site [nucleotide binding]; other site 862908007582 L21 binding site [polypeptide binding]; other site 862908007583 L13 binding site [polypeptide binding]; other site 862908007584 HMMPfam hit to PF00453, Ribosomal protein L20, score 1.5e-32 862908007585 PS00937 Ribosomal protein L20 signature. 862908007586 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 862908007587 HMMPfam hit to PF01632, Ribosomal protein L35, score 2.4e-23 862908007588 PS00936 Ribosomal protein L35 signature. 862908007589 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 862908007590 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862908007591 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862908007592 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 862908007593 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 862908007594 putative acyl-acceptor binding pocket; other site 862908007595 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 4.5e-16 862908007596 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 862908007597 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 862908007598 active site 862908007599 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 1.3e-140 862908007600 PS00487 IMP dehydrogenase / GMP reductase signature. 862908007601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862908007602 putative DNA binding site [nucleotide binding]; other site 862908007603 putative Zn2+ binding site [ion binding]; other site 862908007604 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 862908007605 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 862908007606 PhoU domain; Region: PhoU; pfam01895 862908007607 8 probable transmembrane helices predicted for BMS2037 by TMHMM2.0 at aa 7-29, 53-75, 82-104, 108-130, 137-156, 176-198, 241-263 and 278-299 862908007608 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 6.1e-05 862908007609 Signal peptide predicted for BMS2037 by SignalP 2.0 HMM (Signal peptide probability 0.750) with cleavage site probability 0.463 between residues 33 and 34 862908007610 1 probable transmembrane helix predicted for BMS2038 by TMHMM2.0 at aa 87-109 862908007611 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 862908007612 NAD(P) binding pocket [chemical binding]; other site 862908007613 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 862908007614 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 862908007615 domain interfaces; other site 862908007616 active site 862908007617 HMMPfam hit to PF01379, Porphobilinogen deaminase, score 4.5e-55 862908007618 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 862908007619 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862908007620 inhibitor-cofactor binding pocket; inhibition site 862908007621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908007622 catalytic residue [active] 862908007623 HMMPfam hit to PF00202, Aminotransferase class-III, score 3.8e-65 862908007624 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 862908007625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908007626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908007627 dimer interface [polypeptide binding]; other site 862908007628 phosphorylation site [posttranslational modification] 862908007629 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 862908007630 ATP binding site [chemical binding]; other site 862908007631 Mg2+ binding site [ion binding]; other site 862908007632 G-X-G motif; other site 862908007633 Signal peptide predicted for BMS2042 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.898 between residues 22 and 23 862908007634 2 probable transmembrane helices predicted for BMS2042 by TMHMM2.0 at aa 7-29 and 60-79 862908007635 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3e-13 862908007636 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.7e-08 862908007637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908007638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908007639 active site 862908007640 phosphorylation site [posttranslational modification] 862908007641 intermolecular recognition site; other site 862908007642 dimerization interface [polypeptide binding]; other site 862908007643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908007644 DNA binding site [nucleotide binding] 862908007645 HMMPfam hit to PF00072, Response regulator receiver, score 2.3e-30 862908007646 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.8e-15 862908007647 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 862908007648 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 3.5e-50 862908007649 PS00906 Uroporphyrinogen decarboxylase signature 1. 862908007650 PS00907 Uroporphyrinogen decarboxylase signature 2. 862908007651 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 862908007652 HMMPfam hit to PF04055, Radical SAM, score 1.2e-21 862908007653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007654 PS00591 Glycosyl hydrolases family 10 active site. 862908007655 HMMPfam hit to PF06969, HemN, C-terminal, score 0.0013 862908007656 Signal peptide predicted for BMS2046 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.946 between residues 18 and 19 862908007657 1 probable transmembrane helix predicted for BMS2046 by TMHMM2.0 at aa 7-29 862908007658 Signal peptide predicted for BMS2047 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.950 between residues 18 and 19 862908007659 1 probable transmembrane helix predicted for BMS2047 by TMHMM2.0 at aa 7-29 862908007660 1 probable transmembrane helix predicted for BMS2049 by TMHMM2.0 at aa 13-35 862908007661 Signal peptide predicted for BMS2049 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 28 and 29 862908007662 Signal peptide predicted for BMS2050 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.903 between residues 42 and 43 862908007663 Signal peptide predicted for BMS2052 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 20 and 21 862908007664 PS00063 Aldo/keto reductase family putative active site signature. 862908007665 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 862908007666 HMMPfam hit to PF03631, Ribonuclease BN, score 2.2e-09 862908007667 6 probable transmembrane helices predicted for BMS2054 by TMHMM2.0 at aa 50-72, 118-140, 153-171, 191-213, 226-248 and 267-289 862908007668 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 862908007669 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 862908007670 NAD binding site [chemical binding]; other site 862908007671 homotetramer interface [polypeptide binding]; other site 862908007672 homodimer interface [polypeptide binding]; other site 862908007673 substrate binding site [chemical binding]; other site 862908007674 active site 862908007675 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.9e-09 862908007676 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908007678 active site 862908007679 phosphorylation site [posttranslational modification] 862908007680 intermolecular recognition site; other site 862908007681 dimerization interface [polypeptide binding]; other site 862908007682 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908007683 DNA binding site [nucleotide binding] 862908007684 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 5.4e-16 862908007685 HMMPfam hit to PF00072, Response regulator receiver, score 8.7e-40 862908007686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908007687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908007688 dimer interface [polypeptide binding]; other site 862908007689 phosphorylation site [posttranslational modification] 862908007690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908007691 ATP binding site [chemical binding]; other site 862908007692 Mg2+ binding site [ion binding]; other site 862908007693 G-X-G motif; other site 862908007694 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.6e-25 862908007695 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 4.6e-13 862908007696 2 probable transmembrane helices predicted for BMS2057 by TMHMM2.0 at aa 13-35 and 63-85 862908007697 Signal peptide predicted for BMS2057 by SignalP 2.0 HMM (Signal peptide probability 0.841) with cleavage site probability 0.503 between residues 37 and 38 862908007698 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862908007699 intersubunit interface [polypeptide binding]; other site 862908007700 active site 862908007701 catalytic residue [active] 862908007702 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 2.6e-105 862908007703 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 862908007704 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 862908007705 HMMPfam hit to PF01089, Delta 1-pyrroline-5-carboxylate reductase, score 7.7e-44 862908007706 Proline dehydrogenase; Region: Pro_dh; cl03282 862908007707 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908007708 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 862908007709 NAD(P) binding site [chemical binding]; other site 862908007710 catalytic residues [active] 862908007711 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 9.2e-81 862908007712 PS00070 Aldehyde dehydrogenases cysteine active site. 862908007713 HMMPfam hit to PF01619, Proline dehydrogenase, score 7.1e-41 862908007714 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908007715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908007716 active site 862908007717 phosphorylation site [posttranslational modification] 862908007718 intermolecular recognition site; other site 862908007719 dimerization interface [polypeptide binding]; other site 862908007720 HMMPfam hit to PF00072, Response regulator receiver, score 4e-06 862908007721 Signal peptide predicted for BMS2063 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.996 between residues 21 and 22 862908007722 Signal peptide predicted for BMS2064 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.578 between residues 18 and 19 862908007723 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 862908007724 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862908007725 N-terminal plug; other site 862908007726 ligand-binding site [chemical binding]; other site 862908007727 Signal peptide predicted for BMS2065 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 29 and 30 862908007728 HMMPfam hit to PF07715, , score 7.6e-22 862908007729 HMMPfam hit to PF00593, TonB-dependent receptor, score 6.9e-16 862908007730 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 862908007731 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 862908007732 Signal peptide predicted for BMS2066 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.424 between residues 17 and 18 862908007733 SWI complex, BAF60b domains; Region: SWIB; smart00151 862908007734 HMMPfam hit to PF02201, SWIB complex, BAF60b, score 6.8e-32 862908007735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862908007736 Cytochrome c553 [Energy production and conversion]; Region: COG2863 862908007737 HMMPfam hit to PF00034, Cytochrome c, class I, score 4.1e-09 862908007738 PS00190 Cytochrome c family heme-binding site signature. 862908007739 Signal peptide predicted for BMS2069 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 20 and 21 862908007740 Thiamine pyrophosphokinase; Region: TPK; cl08415 862908007741 active site 862908007742 dimerization interface [polypeptide binding]; other site 862908007743 thiamine binding site [chemical binding]; other site 862908007744 HMMPfam hit to PF04263, Thiamin pyrophosphokinase, catalytic region, score 0.00035 862908007745 Penicillin amidase; Region: Penicil_amidase; pfam01804 862908007746 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 862908007747 active site 862908007748 HMMPfam hit to PF01804, Peptidase S45, penicillin amidase, score 3.4e-133 862908007749 1 probable transmembrane helix predicted for BMS2072 by TMHMM2.0 at aa 9-31 862908007750 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 862908007751 7 probable transmembrane helices predicted for BMS2073 by TMHMM2.0 at aa 13-32, 47-69, 76-98, 103-122, 127-149, 159-179 and 200-222 862908007752 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 862908007753 4 probable transmembrane helices predicted for BMS2074 by TMHMM2.0 at aa 30-52, 72-91, 98-120 and 527-544 862908007754 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 862908007755 Signal peptide predicted for BMS2075 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 18 and 19 862908007756 9 probable transmembrane helices predicted for BMS2075 by TMHMM2.0 at aa 216-238, 243-265, 275-294, 301-323, 343-365, 385-407, 422-441, 448-470 and 485-507 862908007757 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 5.1e-21 862908007758 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862908007759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908007760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908007761 ABC transporter; Region: ABC_tran_2; pfam12848 862908007762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908007763 ABC transporter; Region: ABC_tran_2; pfam12848 862908007764 HMMPfam hit to PF00005, ABC transporter, score 5.7e-47 862908007765 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007766 PS00211 ABC transporters family signature. 862908007767 HMMPfam hit to PF00005, ABC transporter, score 8.1e-42 862908007768 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007769 PS00211 ABC transporters family signature. 862908007770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862908007771 catalytic tetrad [active] 862908007772 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862908007773 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862908007774 active site 862908007775 catalytic site [active] 862908007776 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 2.6e-16 862908007777 PS00037 Myb DNA-binding domain repeat signature 1. 862908007778 Signal peptide predicted for BMS2080 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 20 and 21 862908007779 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862908007780 2 probable transmembrane helices predicted for BMS2081 by TMHMM2.0 at aa 37-59 and 64-86 862908007781 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 862908007782 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 862908007783 non-specific DNA interactions [nucleotide binding]; other site 862908007784 DNA binding site [nucleotide binding] 862908007785 sequence specific DNA binding site [nucleotide binding]; other site 862908007786 putative cAMP binding site [chemical binding]; other site 862908007787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908007788 Coenzyme A binding pocket [chemical binding]; other site 862908007789 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.5e-08 862908007790 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 862908007791 metal binding triad [ion binding]; metal-binding site 862908007792 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase, score 9.2e-06 862908007793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908007794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908007795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908007796 dimerization interface [polypeptide binding]; other site 862908007797 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.3e-15 862908007798 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-21 862908007799 PS00044 Bacterial regulatory proteins, lysR family signature. 862908007800 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862908007801 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862908007802 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 2e-05 862908007803 PS00673 Serine proteases, V8 family, serine active site. 862908007804 PS00134 Serine proteases, trypsin family, histidine active site. 862908007805 PS00672 Serine proteases, V8 family, histidine active site. 862908007806 Signal peptide predicted for BMS2088 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 19 and 20 862908007807 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007808 Signal peptide predicted for BMS2089 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.547 between residues 18 and 19 862908007809 Signal peptide predicted for BMS2090 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 20 and 21 862908007810 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 862908007811 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 0.00012 862908007812 PS00134 Serine proteases, trypsin family, histidine active site. 862908007813 Signal peptide predicted for BMS2091 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.923 between residues 17 and 18 862908007814 elongation factor G; Reviewed; Region: PRK00007 862908007815 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862908007816 G1 box; other site 862908007817 putative GEF interaction site [polypeptide binding]; other site 862908007818 GTP/Mg2+ binding site [chemical binding]; other site 862908007819 Switch I region; other site 862908007820 G2 box; other site 862908007821 G3 box; other site 862908007822 Switch II region; other site 862908007823 G4 box; other site 862908007824 G5 box; other site 862908007825 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 862908007826 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862908007827 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862908007828 HMMPfam hit to PF00679, Elongation factor G, C-terminal, score 2.4e-46 862908007829 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 2.4e-54 862908007830 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 1.8e-18 862908007831 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.9e-97 862908007832 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908007834 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908007835 substrate binding pocket [chemical binding]; other site 862908007836 membrane-bound complex binding site; other site 862908007837 hinge residues; other site 862908007838 Signal peptide predicted for BMS2094 by SignalP 2.0 HMM (Signal peptide probability 0.772) with cleavage site probability 0.732 between residues 19 and 20 862908007839 Signal peptide predicted for BMS2096 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.574 between residues 21 and 22 862908007840 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007841 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 862908007842 catalytic triad [active] 862908007843 putative active site [active] 862908007844 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 5.2e-48 862908007845 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 862908007846 PS00138 Serine proteases, subtilase family, serine active site. 862908007847 PS00137 Serine proteases, subtilase family, histidine active site. 862908007848 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908007849 Signal peptide predicted for BMS2097 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 862908007850 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908007851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908007852 substrate binding pocket [chemical binding]; other site 862908007853 membrane-bound complex binding site; other site 862908007854 hinge residues; other site 862908007855 Signal peptide predicted for BMS2098 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 19 and 20 862908007856 1 probable transmembrane helix predicted for BMS2098 by TMHMM2.0 at aa 5-27 862908007857 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007858 Signal peptide predicted for BMS2099 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.538 between residues 22 and 23 862908007859 Signal peptide predicted for BMS2100 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.737 between residues 19 and 20 862908007860 MarC family integral membrane protein; Region: MarC; cl00919 862908007861 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 5.3e-50 862908007862 6 probable transmembrane helices predicted for BMS2101 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 115-137, 147-166 and 187-209 862908007863 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 862908007864 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 862908007865 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 862908007866 Signal peptide predicted for BMS2102 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 862908007867 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908007868 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862908007869 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862908007870 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862908007871 1 probable transmembrane helix predicted for BMS2103 by TMHMM2.0 at aa 5-27 862908007872 HMMPfam hit to PF00023, Ankyrin, score 0.022 862908007873 HMMPfam hit to PF00023, Ankyrin, score 3.6e-06 862908007874 HMMPfam hit to PF00023, Ankyrin, score 0.089 862908007875 HMMPfam hit to PF00023, Ankyrin, score 0.00012 862908007876 HMMPfam hit to PF00023, Ankyrin, score 2.3e-05 862908007877 Signal peptide predicted for BMS2104 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.519 between residues 23 and 24 862908007878 Signal peptide predicted for BMS2106 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.489 between residues 21 and 22 862908007879 MltA-interacting protein MipA; Region: MipA; cl01504 862908007880 HMMPfam hit to PF06629, MltA-interacting MipA, score 0.0062 862908007881 1 probable transmembrane helix predicted for BMS2107 by TMHMM2.0 at aa 13-32 862908007882 Signal peptide predicted for BMS2107 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.355 between residues 31 and 32 862908007883 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908007884 11 probable transmembrane helices predicted for BMS2109 by TMHMM2.0 at aa 13-32, 329-351, 371-393, 428-450, 460-482, 518-535, 862-884, 891-913, 918-940, 966-988 and 1003-1025 862908007885 HMMPfam hit to PF00873, Acriflavin resistance protein, score 4.3e-88 862908007886 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007887 Outer membrane efflux protein; Region: OEP; pfam02321 862908007888 Signal peptide predicted for BMS2110 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.892 between residues 25 and 26 862908007889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908007890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908007891 HMMPfam hit to PF00440, Bacterial regulatory protein, TetR, score 3.3e-08 862908007892 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862908007893 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 862908007894 Signal peptide predicted for BMS2114 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.983 between residues 18 and 19 862908007895 Signal peptide predicted for BMS2115 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.876 between residues 41 and 42 862908007896 Signal peptide predicted for BMS2116 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 19 and 20 862908007897 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862908007898 IHF dimer interface [polypeptide binding]; other site 862908007899 IHF - DNA interface [nucleotide binding]; other site 862908007900 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 3.7e-21 862908007901 PS00045 Bacterial histone-like DNA-binding proteins signature. 862908007902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908007903 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862908007904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908007905 catalytic residue [active] 862908007906 HMMPfam hit to PF00266, Aminotransferase, class V, score 2e-25 862908007907 Transcriptional regulator; Region: Rrf2; cl17282 862908007908 Rrf2 family protein; Region: rrf2_super; TIGR00738 862908007909 HMMPfam hit to PF02082, Protein of unknown function UPF0074, score 3.1e-37 862908007910 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 862908007911 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007912 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 862908007913 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 862908007914 putative substrate binding site [chemical binding]; other site 862908007915 putative ATP binding site [chemical binding]; other site 862908007916 HMMPfam hit to PF01256, Protein of unknown function UPF0031, score 2.3e-53 862908007917 PS01050 Uncharacterized protein family UPF0031 signature 2. 862908007918 PS01049 Uncharacterized protein family UPF0031 signature 1. 862908007919 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908007920 HMMPfam hit to PF03853, YjeF-related protein, N-terminal, score 1.7e-23 862908007921 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 862908007922 active site 862908007923 hydrophilic channel; other site 862908007924 dimerization interface [polypeptide binding]; other site 862908007925 catalytic residues [active] 862908007926 active site lid [active] 862908007927 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthetic protein PdxJ, score 2.7e-76 862908007928 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 862908007929 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 862908007930 active site 862908007931 substrate binding site [chemical binding]; other site 862908007932 metal binding site [ion binding]; metal-binding site 862908007933 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C terminal, score 5.2e-05 862908007934 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 1.8e-25 862908007935 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 3.4e-27 862908007936 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 7.4e-53 862908007937 YbbR-like protein; Region: YbbR; pfam07949 862908007938 Signal peptide predicted for BMS2125 by SignalP 2.0 HMM (Signal peptide probability 0.773) with cleavage site probability 0.750 between residues 36 and 37 862908007939 1 probable transmembrane helix predicted for BMS2125 by TMHMM2.0 at aa 13-35 862908007940 Uncharacterized conserved protein [Function unknown]; Region: COG1624 862908007941 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 862908007942 HMMPfam hit to PF02457, Protein of unknown function DUF147, score 6.4e-55 862908007943 2 probable transmembrane helices predicted for BMS2126 by TMHMM2.0 at aa 36-58 and 60-82 862908007944 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 862908007945 PilZ domain; Region: PilZ; pfam07238 862908007946 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 862908007947 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 862908007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908007949 Walker A motif; other site 862908007950 ATP binding site [chemical binding]; other site 862908007951 Walker B motif; other site 862908007952 arginine finger; other site 862908007953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908007954 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 7.8e-09 862908007955 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 1.1e-18 862908007956 PS00017 ATP/GTP-binding site motif A (P-loop). 862908007957 HMMPfam hit to PF01590, GAF, score 1.2e-16 862908007958 Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253 862908007959 HMMPfam hit to PF01536, S-adenosylmethionine decarboxylase, score 7e-36 862908007960 PS01336 S-adenosylmethionine decarboxylase signature. 862908007961 spermidine synthase; Provisional; Region: PRK00811 862908007962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908007963 S-adenosylmethionine binding site [chemical binding]; other site 862908007964 HMMPfam hit to PF01564, Spermine synthase, score 4.1e-95 862908007965 EVE domain; Region: EVE; cl00728 862908007966 HMMPfam hit to PF04543, Protein of unknown function DUF589, score 5.4e-84 862908007967 CHASE4 domain; Region: CHASE4; cl01308 862908007968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908007969 HAMP domain; Region: HAMP; pfam00672 862908007970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908007971 dimer interface [polypeptide binding]; other site 862908007972 phosphorylation site [posttranslational modification] 862908007973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908007974 ATP binding site [chemical binding]; other site 862908007975 Mg2+ binding site [ion binding]; other site 862908007976 G-X-G motif; other site 862908007977 2 probable transmembrane helices predicted for BMS2133 by TMHMM2.0 at aa 10-31 and 255-277 862908007978 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.6e-07 862908007979 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.3e-07 862908007980 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.4e-25 862908007981 arginine decarboxylase; Provisional; Region: PRK05354 862908007982 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 862908007983 dimer interface [polypeptide binding]; other site 862908007984 active site 862908007985 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862908007986 catalytic residues [active] 862908007987 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 862908007988 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 1.4e-15 862908007989 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 3.6e-54 862908007990 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 862908007991 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 862908007992 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 862908007993 agmatinase; Region: agmatinase; TIGR01230 862908007994 putative active site [active] 862908007995 Mn binding site [ion binding]; other site 862908007996 HMMPfam hit to PF00491, Arginase/agmatinase/formiminoglutamase, score 1.5e-17 862908007997 PS01053 Arginase family signature 3. 862908007998 PS00148 Arginase family signature 2. 862908007999 PS00147 Arginase family signature 1. 862908008000 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908008001 active site 862908008002 Zn binding site [ion binding]; other site 862908008003 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 1.7e-06 862908008004 Signal peptide predicted for BMS2136 by SignalP 2.0 HMM (Signal peptide probability 0.616) with cleavage site probability 0.217 between residues 21 and 22 862908008005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008006 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862908008007 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908008008 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 862908008009 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 862908008010 putative active site [active] 862908008011 catalytic site [active] 862908008012 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908008013 putative active site [active] 862908008014 catalytic site [active] 862908008015 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.32 862908008016 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.0075 862908008017 Signal peptide predicted for BMS2138 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.932 between residues 22 and 23 862908008018 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 862908008019 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 862908008020 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 862908008021 heme binding site [chemical binding]; other site 862908008022 ferroxidase pore; other site 862908008023 ferroxidase diiron center [ion binding]; other site 862908008024 HMMPfam hit to PF00210, Ferritin and Dps, score 7.6e-49 862908008025 Signal peptide predicted for BMS2141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.547 between residues 20 and 21 862908008026 ferrochelatase; Reviewed; Region: hemH; PRK00035 862908008027 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 862908008028 C-terminal domain interface [polypeptide binding]; other site 862908008029 active site 862908008030 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 862908008031 active site 862908008032 N-terminal domain interface [polypeptide binding]; other site 862908008033 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 862908008034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908008035 putative substrate translocation pore; other site 862908008036 13 probable transmembrane helices predicted for BMS2142 by TMHMM2.0 at aa 390-412, 424-443, 448-470, 482-501, 506-528, 541-563, 578-600, 640-662, 672-691, 703-725, 729-751, 764-783 and 793-810 862908008037 HMMPfam hit to PF07690, , score 9.7e-47 862908008038 HMMPfam hit to PF00762, Ferrochelatase, score 1.5e-47 862908008039 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 862908008040 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 1.6e-44 862908008041 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 862908008042 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 7.1e-14 862908008043 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 862908008044 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 862908008045 Response regulator receiver domain; Region: Response_reg; pfam00072 862908008046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008047 active site 862908008048 phosphorylation site [posttranslational modification] 862908008049 intermolecular recognition site; other site 862908008050 dimerization interface [polypeptide binding]; other site 862908008051 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-05 862908008052 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 862908008053 hypothetical protein; Provisional; Region: PRK00468 862908008054 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 862908008055 HMMPfam hit to PF00886, Ribosomal protein S16, score 1.2e-15 862908008056 PS00036 bZIP transcription factors basic domain signature. 862908008057 Signal peptide predicted for BMS2149 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.554 between residues 19 and 20 862908008058 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 862908008059 Signal peptide predicted for BMS2150 by SignalP 2.0 HMM (Signal peptide probability 0.932) with cleavage site probability 0.602 between residues 32 and 33 862908008060 Signal peptide predicted for BMS2152 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.618 between residues 21 and 22 862908008061 1 probable transmembrane helix predicted for BMS2152 by TMHMM2.0 at aa 5-24 862908008062 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 862908008063 Signal peptide predicted for BMS2153 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.833 between residues 17 and 18 862908008064 HMMPfam hit to PF05594, Haemagluttinin, score 3.3 862908008065 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 862908008066 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 862908008067 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 862908008068 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 862908008069 gamma-gamma dimer interface [polypeptide binding]; other site 862908008070 Ca2+ binding site [ion binding]; other site 862908008071 polymerization pocket; other site 862908008072 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 862908008073 Signal peptide predicted for BMS2154 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.622 between residues 18 and 19 862908008074 HMMPfam hit to PF00147, Fibrinogen, beta/gamma chain, C-terminal globular, score 8.7e-08 862908008075 signal recognition particle protein; Provisional; Region: PRK10867 862908008076 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 862908008077 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862908008078 Signal peptide binding domain; Region: SRP_SPB; pfam02978 862908008079 HMMPfam hit to PF02978, Signal peptide binding (SRP54) M-domain, score 2.7e-40 862908008080 HMMPfam hit to PF00448, GTP-binding signal recognition particle SRP54, G-domain, score 1.9e-96 862908008081 PS00300 SRP54-type proteins GTP-binding domain signature. 862908008082 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008083 HMMPfam hit to PF02881, GTP-binding signal recognition particle SRP54, G-domain, score 5.4e-30 862908008084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862908008085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908008086 motif II; other site 862908008087 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.3e-14 862908008088 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 862908008089 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862908008090 FMN binding site [chemical binding]; other site 862908008091 active site 862908008092 catalytic residues [active] 862908008093 substrate binding site [chemical binding]; other site 862908008094 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 9.5e-66 862908008095 PS01136 Uncharacterized protein family UPF0034 signature. 862908008096 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862908008097 Cytochrome c; Region: Cytochrom_C; pfam00034 862908008098 HMMPfam hit to PF00034, Cytochrome c, class I, score 1.3e-10 862908008099 PS00190 Cytochrome c family heme-binding site signature. 862908008100 Signal peptide predicted for BMS2158 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 862908008101 Signal peptide predicted for BMS2159 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 862908008102 Signal peptide predicted for BMS2160 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.502 between residues 38 and 39 862908008103 1 probable transmembrane helix predicted for BMS2160 by TMHMM2.0 at aa 7-26 862908008104 Signal peptide predicted for BMS2161 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.859 between residues 14 and 15 862908008105 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908008106 putative catalytic site [active] 862908008107 putative metal binding site [ion binding]; other site 862908008108 putative phosphate binding site [ion binding]; other site 862908008109 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 5.5e-11 862908008110 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908008111 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862908008112 catalytic residues [active] 862908008113 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 1.1e-06 862908008114 Signal peptide predicted for BMS2164 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.654 between residues 30 and 31 862908008115 1 probable transmembrane helix predicted for BMS2164 by TMHMM2.0 at aa 7-29 862908008116 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008117 Protein of unknown function (DUF523); Region: DUF523; cl00733 862908008118 HMMPfam hit to PF04463, Protein of unknown function DUF523, score 1.9e-23 862908008119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908008120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908008121 dimer interface [polypeptide binding]; other site 862908008122 phosphorylation site [posttranslational modification] 862908008123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908008124 ATP binding site [chemical binding]; other site 862908008125 Mg2+ binding site [ion binding]; other site 862908008126 G-X-G motif; other site 862908008127 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.6e-26 862908008128 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 5.3e-10 862908008129 2 probable transmembrane helices predicted for BMS2166 by TMHMM2.0 at aa 17-39 and 156-178 862908008130 Signal peptide predicted for BMS2166 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.673 between residues 34 and 35 862908008131 flagellin; Provisional; Region: PRK12802 862908008132 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908008133 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862908008134 HMMPfam hit to PF00700, Flagellin, C-terminal, score 1.1e-27 862908008135 HMMPfam hit to PF00669, Flagellin, N-terminal, score 4.8e-43 862908008136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908008137 Zn2+ binding site [ion binding]; other site 862908008138 Mg2+ binding site [ion binding]; other site 862908008139 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 862908008140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008141 active site 862908008142 phosphorylation site [posttranslational modification] 862908008143 intermolecular recognition site; other site 862908008144 dimerization interface [polypeptide binding]; other site 862908008145 HMMPfam hit to PF00072, Response regulator receiver, score 2.8e-24 862908008146 HMMPfam hit to PF01627, Hpt, score 9.4e-07 862908008147 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 862908008148 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 862908008149 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 862908008150 putative active site [active] 862908008151 putative metal binding site [ion binding]; other site 862908008152 1 probable transmembrane helix predicted for BMS2173 by TMHMM2.0 at aa 239-261 862908008153 Signal peptide predicted for BMS2174 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.484 between residues 17 and 18 862908008154 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008155 1 probable transmembrane helix predicted for BMS2176 by TMHMM2.0 at aa 12-31 862908008156 Signal peptide predicted for BMS2176 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.944 between residues 28 and 29 862908008157 Signal peptide predicted for BMS2177 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.960 between residues 20 and 21 862908008158 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908008159 1 probable transmembrane helix predicted for BMS2179 by TMHMM2.0 at aa 7-26 862908008160 Signal peptide predicted for BMS2179 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.936 between residues 25 and 26 862908008161 Signal peptide predicted for BMS2180 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.992 between residues 26 and 27 862908008162 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 862908008163 excinuclease ABC subunit B; Provisional; Region: PRK05298 862908008164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908008165 ATP binding site [chemical binding]; other site 862908008166 putative Mg++ binding site [ion binding]; other site 862908008167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908008168 nucleotide binding region [chemical binding]; other site 862908008169 ATP-binding site [chemical binding]; other site 862908008170 Ultra-violet resistance protein B; Region: UvrB; pfam12344 862908008171 UvrB/uvrC motif; Region: UVR; pfam02151 862908008172 HMMPfam hit to PF02151, UvrB/UvrC protein, score 5.9e-11 862908008173 HMMPfam hit to PF00271, Helicase, C-terminal, score 3.7e-20 862908008174 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 9.3e-07 862908008175 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008176 diaminopimelate decarboxylase; Region: lysA; TIGR01048 862908008177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 862908008178 active site 862908008179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862908008180 substrate binding site [chemical binding]; other site 862908008181 catalytic residues [active] 862908008182 dimer interface [polypeptide binding]; other site 862908008183 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 6.2e-55 862908008184 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 862908008185 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 862908008186 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 2.3e-36 862908008187 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 862908008188 HMMPfam hit to PF02559, Transcription factor CarD, score 1.3e-15 862908008189 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 862908008190 active site 862908008191 multimer interface [polypeptide binding]; other site 862908008192 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 4.1e-72 862908008193 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 862908008194 CoA binding domain; Region: CoA_binding; smart00881 862908008195 CoA-ligase; Region: Ligase_CoA; pfam00549 862908008196 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 8.7e-52 862908008197 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 862908008198 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 862908008199 HMMPfam hit to PF02629, CoA-binding, score 1.6e-58 862908008200 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 862908008201 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 862908008202 CoA-ligase; Region: Ligase_CoA; pfam00549 862908008203 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 2.2e-79 862908008204 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 862908008205 HMMPfam hit to PF02222, ATP-dependent carboxylate-amine ligase-like, ATP-grasp, score 1.1e-22 862908008206 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908008208 Q-loop/lid; other site 862908008209 ABC transporter signature motif; other site 862908008210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862908008211 D-loop; other site 862908008212 HMMPfam hit to PF00753, Beta-lactamase-like, score 4.7e-14 862908008213 PS00136 Serine proteases, subtilase family, aspartic acid active site. 862908008214 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 862908008215 1 probable transmembrane helix predicted for BMS2189 by TMHMM2.0 at aa 247-269 862908008216 Signal peptide predicted for BMS2190 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.949 between residues 19 and 20 862908008217 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 862908008218 active site 862908008219 metal binding site [ion binding]; metal-binding site 862908008220 PS00148 Arginase family signature 2. 862908008221 Signal peptide predicted for BMS2195 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.990 between residues 23 and 24 862908008222 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 862908008223 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 862908008224 putative Iron-sulfur protein interface [polypeptide binding]; other site 862908008225 proximal heme binding site [chemical binding]; other site 862908008226 distal heme binding site [chemical binding]; other site 862908008227 putative dimer interface [polypeptide binding]; other site 862908008228 5 probable transmembrane helices predicted for BMS2196 by TMHMM2.0 at aa 21-43, 61-83, 104-126, 158-180 and 201-223 862908008229 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 862908008230 L-aspartate oxidase; Provisional; Region: PRK06175 862908008231 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862908008232 Signal peptide predicted for BMS2197 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.477 between residues 53 and 54 862908008233 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 6.5e-46 862908008234 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 4.8e-19 862908008235 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 862908008236 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 862908008237 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 862908008238 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.0015 862908008239 SprT homologues; Region: SprT; cl01182 862908008240 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 862908008241 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862908008242 CoenzymeA binding site [chemical binding]; other site 862908008243 subunit interaction site [polypeptide binding]; other site 862908008244 PHB binding site; other site 862908008245 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.6e-08 862908008246 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 862908008247 Signal peptide predicted for BMS2201 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 30 and 31 862908008248 HMMPfam hit to PF04241, Protein of unknown function DUF423, score 1.9e-36 862908008249 4 probable transmembrane helices predicted for BMS2201 by TMHMM2.0 at aa 12-31, 46-63, 75-97 and 101-123 862908008250 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 862908008251 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 862908008252 HMMPfam hit to PF04055, Radical SAM, score 1.7e-07 862908008253 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 862908008254 Signal peptide predicted for BMS2205 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 18 and 19 862908008255 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 862908008256 active site 862908008257 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 862908008258 Signal peptide predicted for BMS2206 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.836 between residues 25 and 26 862908008259 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 862908008260 HMMPfam hit to PF01258, Zn-finger, prokaryotic DksA/TraR C4 type, score 1.4e-08 862908008261 Signal peptide predicted for BMS2211 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.521 between residues 23 and 24 862908008262 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008263 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 862908008264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 862908008265 ATP binding site [chemical binding]; other site 862908008266 putative Mg++ binding site [ion binding]; other site 862908008267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908008268 nucleotide binding region [chemical binding]; other site 862908008269 ATP-binding site [chemical binding]; other site 862908008270 HMMPfam hit to PF00271, Helicase, C-terminal, score 1.6e-26 862908008271 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 2.3e-41 862908008272 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008273 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 862908008274 Signal peptide predicted for BMS2215 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.992 between residues 22 and 23 862908008275 FHA domain; Region: FHA; pfam00498 862908008276 phosphopeptide binding site; other site 862908008277 HMMPfam hit to PF00498, Forkhead-associated, score 2.6e-08 862908008278 3 probable transmembrane helices predicted for BMS2216 by TMHMM2.0 at aa 230-249, 286-308 and 373-395 862908008279 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 862908008280 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 862908008281 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 3.8e-130 862908008282 Signal peptide predicted for BMS2218 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.909 between residues 16 and 17 862908008283 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862908008285 TPR motif; other site 862908008286 binding surface 862908008287 Signal peptide predicted for BMS2220 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 862908008288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908008289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908008290 catalytic residue [active] 862908008291 Signal peptide predicted for BMS2222 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 862908008292 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908008293 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908008294 active site 862908008295 active site 862908008296 Signal peptide predicted for BMS2223 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.596 between residues 27 and 28 862908008297 HMMPfam hit to PF00413, Peptidase M10A and M12B, matrixin and adamalysin, score 8.5e-05 862908008298 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008299 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 862908008300 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 862908008301 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 862908008302 active site 862908008303 HMMPfam hit to PF00557, Peptidase M24, score 2.5e-15 862908008304 PS00491 Aminopeptidase P and proline dipeptidase signature. 862908008305 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 862908008306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908008307 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 1.5e-14 862908008308 1 probable transmembrane helix predicted for BMS2225 by TMHMM2.0 at aa 7-29 862908008309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908008310 S-adenosylmethionine binding site [chemical binding]; other site 862908008311 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 862908008312 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 862908008313 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 862908008314 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 862908008315 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 862908008316 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008317 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 1.1e-20 862908008318 PS00181 Glutamine synthetase putative ATP-binding region signature. 862908008319 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 862908008320 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 862908008321 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 862908008322 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 862908008323 protein binding site [polypeptide binding]; other site 862908008324 HMMPfam hit to PF05299, Peptidase M61, score 3.2e-47 862908008325 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008326 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 862908008327 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 2.3e-06 862908008328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908008329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908008330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908008331 dimerization interface [polypeptide binding]; other site 862908008332 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.2e-14 862908008333 PS00044 Bacterial regulatory proteins, lysR family signature. 862908008334 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.8e-16 862908008335 PS00496 P-II protein urydylation site. 862908008336 Signal peptide predicted for BMS2233 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 18 and 19 862908008337 Signal peptide predicted for BMS2234 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.535 between residues 19 and 20 862908008338 HMMPfam hit to PF01706, Flagellar motor switch protein FliG, score 2.5e-07 862908008339 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 862908008340 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 862908008341 NADP binding site [chemical binding]; other site 862908008342 homopentamer interface [polypeptide binding]; other site 862908008343 substrate binding site [chemical binding]; other site 862908008344 active site 862908008345 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 7.4e-15 862908008346 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 862908008347 metal coordination site [ion binding]; other site 862908008348 Signal peptide predicted for BMS2238 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.832 between residues 18 and 19 862908008349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908008350 dimer interface [polypeptide binding]; other site 862908008351 phosphorylation site [posttranslational modification] 862908008352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908008353 ATP binding site [chemical binding]; other site 862908008354 G-X-G motif; other site 862908008355 Signal peptide predicted for BMS2239 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.605 between residues 40 and 41 862908008356 2 probable transmembrane helices predicted for BMS2239 by TMHMM2.0 at aa 15-37 and 184-203 862908008357 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.7e-10 862908008358 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-25 862908008359 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 862908008360 6 probable transmembrane helices predicted for BMS2240 by TMHMM2.0 at aa 21-43, 70-87, 108-130, 159-181, 193-212 and 217-239 862908008361 HMMPfam hit to PF00902, Sec-independent periplasmic protein translocase, score 2.2e-55 862908008362 Signal peptide predicted for BMS2240 by SignalP 2.0 HMM (Signal peptide probability 0.648) with cleavage site probability 0.648 between residues 35 and 36 862908008363 Signal peptide predicted for BMS2241 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.985 between residues 29 and 30 862908008364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862908008365 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 9.9e-08 862908008366 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862908008367 active site 862908008368 HMMPfam hit to PF00557, Peptidase M24, score 1e-88 862908008369 PS00680 Methionine aminopeptidase subfamily 1 signature. 862908008370 PS00893 mutT domain signature. 862908008371 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 862908008372 Signal peptide predicted for BMS2244 by SignalP 2.0 HMM (Signal peptide probability 0.813) with cleavage site probability 0.460 between residues 21 and 22 862908008373 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862908008374 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 862908008375 NAD binding site [chemical binding]; other site 862908008376 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.7e-11 862908008377 Arginase family; Region: Arginase; pfam00491 862908008378 active site 862908008379 metal binding site [ion binding]; metal-binding site 862908008380 HMMPfam hit to PF00491, Arginase/agmatinase/formiminoglutamase, score 1.4e-17 862908008381 PS00147 Arginase family signature 1. 862908008382 PS00148 Arginase family signature 2. 862908008383 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 862908008384 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA--protein transferase, score 1e-56 862908008385 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908008386 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 862908008387 active site 862908008388 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.1e-08 862908008389 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862908008390 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862908008391 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.00022 862908008392 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.00049 862908008393 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908008394 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 862908008395 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 862908008396 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 862908008397 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 2.8e-45 862908008398 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 862908008399 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 3.5e-17 862908008400 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 862908008401 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 5.3e-16 862908008402 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008403 Signal peptide predicted for BMS2252 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.316 between residues 20 and 21 862908008404 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008405 PilZ domain; Region: PilZ; pfam07238 862908008406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908008407 S-adenosylmethionine binding site [chemical binding]; other site 862908008408 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908008409 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862908008410 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 862908008411 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 862908008412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862908008413 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862908008414 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.7e-53 862908008415 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5e-101 862908008416 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 862908008417 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 862908008418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862908008419 E3 interaction surface; other site 862908008420 lipoyl attachment site [posttranslational modification]; other site 862908008421 e3 binding domain; Region: E3_binding; pfam02817 862908008422 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 862908008423 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 3.1e-135 862908008424 HMMPfam hit to PF02817, E3 binding, score 1.9e-12 862908008425 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 6.6e-21 862908008426 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 862908008427 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 862908008428 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 862908008429 TPP-binding site [chemical binding]; other site 862908008430 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 862908008431 PYR/PP interface [polypeptide binding]; other site 862908008432 dimer interface [polypeptide binding]; other site 862908008433 TPP binding site [chemical binding]; other site 862908008434 HMMPfam hit to PF02779, Transketolase, central region, score 4.8e-63 862908008435 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 3e-40 862908008436 Protein of unknown function (DUF539); Region: DUF539; cl01129 862908008437 1 probable transmembrane helix predicted for BMS2259 by TMHMM2.0 at aa 4-26 862908008438 Signal peptide predicted for BMS2259 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.855 between residues 21 and 22 862908008439 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 862908008440 ApbE family; Region: ApbE; pfam02424 862908008441 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 2.2e-78 862908008442 Signal peptide predicted for BMS2260 by SignalP 2.0 HMM (Signal peptide probability 0.912) with cleavage site probability 0.245 between residues 21 and 22 862908008443 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908008445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908008446 ATP binding site [chemical binding]; other site 862908008447 Mg2+ binding site [ion binding]; other site 862908008448 G-X-G motif; other site 862908008449 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.8e-11 862908008450 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 862908008451 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 862908008452 HMMPfam hit to PF01906, Protein of unknown function DUF74, score 2.9e-10 862908008453 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 862908008454 HMMPfam hit to PF01906, Protein of unknown function DUF74, score 1.2e-53 862908008455 Signal peptide predicted for BMS2264 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.864 between residues 23 and 24 862908008456 Signal peptide predicted for BMS2265 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 18 and 19 862908008457 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 862908008458 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008459 1 probable transmembrane helix predicted for BMS2266 by TMHMM2.0 at aa 26-48 862908008460 Signal peptide predicted for BMS2266 by SignalP 2.0 HMM (Signal peptide probability 0.680) with cleavage site probability 0.677 between residues 44 and 45 862908008461 Signal peptide predicted for BMS2267 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 18 and 19 862908008462 Signal peptide predicted for BMS2268 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.820 between residues 23 and 24 862908008463 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 862908008464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862908008465 catalytic loop [active] 862908008466 iron binding site [ion binding]; other site 862908008467 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 862908008468 FAD binding pocket [chemical binding]; other site 862908008469 FAD binding motif [chemical binding]; other site 862908008470 phosphate binding motif [ion binding]; other site 862908008471 beta-alpha-beta structure motif; other site 862908008472 NAD binding pocket [chemical binding]; other site 862908008473 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 3.9e-20 862908008474 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 3.7e-06 862908008475 HMMPfam hit to PF00111, Ferredoxin, score 2.1e-09 862908008476 Signal peptide predicted for BMS2269 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.521 between residues 25 and 26 862908008477 1 probable transmembrane helix predicted for BMS2269 by TMHMM2.0 at aa 5-24 862908008478 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 862908008479 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 4.8e-101 862908008480 6 probable transmembrane helices predicted for BMS2270 by TMHMM2.0 at aa 13-32, 42-61, 74-96, 111-133, 146-165 and 180-202 862908008481 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 862908008482 5 probable transmembrane helices predicted for BMS2271 by TMHMM2.0 at aa 36-58, 65-82, 97-117, 130-152 and 172-194 862908008483 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 7.5e-82 862908008484 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 862908008485 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 862908008486 HMMPfam hit to PF04205, FMN-binding, score 9.5e-15 862908008487 1 probable transmembrane helix predicted for BMS2272 by TMHMM2.0 at aa 9-31 862908008488 Signal peptide predicted for BMS2272 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.734 between residues 27 and 28 862908008489 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 862908008490 HMMPfam hit to PF03116, NQR2 and RnfD, score 1.8e-130 862908008491 8 probable transmembrane helices predicted for BMS2273 by TMHMM2.0 at aa 61-83, 119-141, 153-175, 257-279, 284-306, 316-338, 345-362 and 366-388 862908008492 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008493 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 862908008494 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 862908008495 HMMPfam hit to PF05896, Na-translocating NADH-quinone reductase subunit A, score 1.4e-246 862908008496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 862908008497 SEC-C motif; Region: SEC-C; pfam02810 862908008498 HMMPfam hit to PF02810, SEC-C motif, score 7.1e-10 862908008499 Methyltransferase domain; Region: Methyltransf_12; pfam08242 862908008500 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 862908008501 putative efflux protein, MATE family; Region: matE; TIGR00797 862908008502 10 probable transmembrane helices predicted for BMS2277 by TMHMM2.0 at aa 12-34, 49-71, 96-118, 138-160, 167-185, 195-217, 316-335, 355-377, 390-407 and 411-433 862908008503 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1e-19 862908008504 Signal peptide predicted for BMS2277 by SignalP 2.0 HMM (Signal peptide probability 0.742) with cleavage site probability 0.528 between residues 30 and 31 862908008505 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 862908008506 4 probable transmembrane helices predicted for BMS2279 by TMHMM2.0 at aa 10-29, 36-58, 63-85 and 97-114 862908008507 Ion channel; Region: Ion_trans_2; pfam07885 862908008508 2 probable transmembrane helices predicted for BMS2280 by TMHMM2.0 at aa 21-43 and 85-107 862908008509 Signal peptide predicted for BMS2282 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.889 between residues 17 and 18 862908008510 Signal peptide predicted for BMS2283 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.738 between residues 19 and 20 862908008511 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 862908008512 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862908008513 active site 862908008514 catalytic site [active] 862908008515 substrate binding site [chemical binding]; other site 862908008516 DEAD/DEAH box helicase; Region: DEAD; pfam00270 862908008517 ATP binding site [chemical binding]; other site 862908008518 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 862908008519 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008520 HMMPfam hit to PF00929, Exonuclease, score 5.1e-11 862908008521 2 probable transmembrane helices predicted for BMS2286 by TMHMM2.0 at aa 45-62 and 82-101 862908008522 BolA-like protein; Region: BolA; pfam01722 862908008523 HMMPfam hit to PF01722, BolA-like protein, score 2.6e-19 862908008524 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 862908008525 putative GSH binding site [chemical binding]; other site 862908008526 catalytic residues [active] 862908008527 hypothetical protein; Validated; Region: PRK00110 862908008528 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 6.7e-123 862908008529 Response regulator receiver domain; Region: Response_reg; pfam00072 862908008530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008531 active site 862908008532 phosphorylation site [posttranslational modification] 862908008533 intermolecular recognition site; other site 862908008534 dimerization interface [polypeptide binding]; other site 862908008535 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-24 862908008536 1 probable transmembrane helix predicted for BMS2292 by TMHMM2.0 at aa 378-400 862908008537 Signal peptide predicted for BMS2292 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 19 and 20 862908008538 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862908008539 active site residue [active] 862908008540 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 862908008541 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 862908008542 substrate-cofactor binding pocket; other site 862908008543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908008544 homodimer interface [polypeptide binding]; other site 862908008545 catalytic residue [active] 862908008546 HMMPfam hit to PF01063, Aminotransferase, class IV, score 1.1e-50 862908008547 1 probable transmembrane helix predicted for BMS2295 by TMHMM2.0 at aa 26-45 862908008548 cryptic adenine deaminase; Provisional; Region: PRK10027 862908008549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908008550 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 862908008551 active site 862908008552 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 862908008553 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008554 HMMPfam hit to PF01979, Amidohydrolase, score 2.4e-38 862908008555 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 862908008556 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 862908008557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862908008558 RNA binding surface [nucleotide binding]; other site 862908008559 HMMPfam hit to PF00163, Ribosomal protein S4, score 1.9e-12 862908008560 HMMPfam hit to PF01479, RNA-binding S4, score 4.3e-16 862908008561 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 862908008562 putative trimer interface [polypeptide binding]; other site 862908008563 putative CoA binding site [chemical binding]; other site 862908008564 3 probable transmembrane helices predicted for BMS2300 by TMHMM2.0 at aa 68-90, 103-125 and 155-177 862908008565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908008566 active site 862908008567 nucleotide binding site [chemical binding]; other site 862908008568 HIGH motif; other site 862908008569 KMSKS motif; other site 862908008570 Predicted permeases [General function prediction only]; Region: RarD; COG2962 862908008571 8 probable transmembrane helices predicted for BMS2302 by TMHMM2.0 at aa 5-22, 33-50, 70-89, 94-116, 173-195, 205-227, 234-256 and 266-285 862908008572 HMMPfam hit to PF00892, Protein of unknown function DUF6, score 8.1e-07 862908008573 HMMPfam hit to PF00892, Protein of unknown function DUF6, score 3.9e-06 862908008574 Signal peptide predicted for BMS2304 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.991 between residues 18 and 19 862908008575 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908008576 active site 862908008577 Zn binding site [ion binding]; other site 862908008578 PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 862908008579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862908008580 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 1.2e-08 862908008581 Signal peptide predicted for BMS2308 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.748 between residues 22 and 23 862908008582 Signal peptide predicted for BMS2310 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.598 between residues 23 and 24 862908008583 1 probable transmembrane helix predicted for BMS2311 by TMHMM2.0 at aa 41-63 862908008584 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 862908008585 putative active site [active] 862908008586 dimerization interface [polypeptide binding]; other site 862908008587 putative tRNAtyr binding site [nucleotide binding]; other site 862908008588 HMMPfam hit to PF02580, D-tyrosyl-tRNA(Tyr) deacylase, score 3.9e-48 862908008589 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908008590 phosphopeptide binding site; other site 862908008591 HMMPfam hit to PF00498, Forkhead-associated, score 3.4e-12 862908008592 FecR protein; Region: FecR; pfam04773 862908008593 Signal peptide predicted for BMS2314 by SignalP 2.0 HMM (Signal peptide probability 0.903) with cleavage site probability 0.873 between residues 19 and 20 862908008594 Signal peptide predicted for BMS2315 by SignalP 2.0 HMM (Signal peptide probability 0.836) with cleavage site probability 0.410 between residues 25 and 26 862908008595 1 probable transmembrane helix predicted for BMS2315 by TMHMM2.0 at aa 7-29 862908008596 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862908008597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908008598 Walker A/P-loop; other site 862908008599 ATP binding site [chemical binding]; other site 862908008600 Q-loop/lid; other site 862908008601 ABC transporter signature motif; other site 862908008602 Walker B; other site 862908008603 D-loop; other site 862908008604 H-loop/switch region; other site 862908008605 TOBE domain; Region: TOBE_2; pfam08402 862908008606 HMMPfam hit to PF00005, ABC transporter, score 6.1e-50 862908008607 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008608 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 862908008609 putative deacylase active site [active] 862908008610 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 1.5e-15 862908008611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908008612 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 862908008613 substrate binding site [chemical binding]; other site 862908008614 oxyanion hole (OAH) forming residues; other site 862908008615 trimer interface [polypeptide binding]; other site 862908008616 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 3.8e-33 862908008617 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 862908008618 PS00134 Serine proteases, trypsin family, histidine active site. 862908008619 HMMPfam hit to PF00708, Acylphosphatase, score 0.019 862908008620 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 862908008621 ligand binding site [chemical binding]; other site 862908008622 active site 862908008623 UGI interface [polypeptide binding]; other site 862908008624 catalytic site [active] 862908008625 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 2.3e-70 862908008626 PS00130 Uracil-DNA glycosylase signature. 862908008627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908008628 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862908008629 Walker A/P-loop; other site 862908008630 ATP binding site [chemical binding]; other site 862908008631 Q-loop/lid; other site 862908008632 ABC transporter signature motif; other site 862908008633 Walker B; other site 862908008634 D-loop; other site 862908008635 H-loop/switch region; other site 862908008636 HMMPfam hit to PF00005, ABC transporter, score 1.2e-41 862908008637 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008638 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 862908008639 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 862908008640 7 probable transmembrane helices predicted for BMS2323 by TMHMM2.0 at aa 29-48, 69-91, 117-139, 144-166, 181-198, 203-225 and 235-257 862908008641 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 1.5e-06 862908008642 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 862908008643 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 1e-15 862908008644 5 probable transmembrane helices predicted for BMS2324 by TMHMM2.0 at aa 34-56, 81-103, 113-135, 172-191 and 195-217 862908008645 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 862908008646 putative deacylase active site [active] 862908008647 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 9.5e-06 862908008648 ABC transporter C family member; Provisional; Region: PLN03232 862908008649 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 862908008650 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 862908008651 active site 862908008652 dimerization interface 3.5A [polypeptide binding]; other site 862908008653 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 4.9e-09 862908008654 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862908008655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908008656 S-adenosylmethionine binding site [chemical binding]; other site 862908008657 phosphodiesterase; Provisional; Region: PRK12704 862908008658 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 862908008659 Signal peptide predicted for BMS2330 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.633 between residues 22 and 23 862908008660 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 862908008661 Signal peptide predicted for BMS2331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 862908008662 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 862908008663 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862908008664 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 862908008665 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908008666 HMMPfam hit to PF07683, , score 4.2e-26 862908008667 HMMPfam hit to PF02492, Cobalamin synthesis protein/P47K, score 1.1e-63 862908008668 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008669 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862908008670 metal binding site 2 [ion binding]; metal-binding site 862908008671 putative DNA binding helix; other site 862908008672 metal binding site 1 [ion binding]; metal-binding site 862908008673 dimer interface [polypeptide binding]; other site 862908008674 structural Zn2+ binding site [ion binding]; other site 862908008675 HMMPfam hit to PF01475, Ferric-uptake regulator, score 9.5e-25 862908008676 MerC mercury resistance protein; Region: MerC; pfam03203 862908008677 4 probable transmembrane helices predicted for BMS2334 by TMHMM2.0 at aa 30-52, 62-81, 93-112 and 127-145 862908008678 methionine sulfoxide reductase A; Provisional; Region: PRK14054 862908008679 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 5.2e-82 862908008680 Signal peptide predicted for BMS2335 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.776 between residues 28 and 29 862908008681 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862908008682 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862908008683 Signal peptide predicted for BMS2337 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19 862908008684 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862908008685 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 862908008686 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 862908008687 HIGH motif; other site 862908008688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908008689 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862908008690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908008691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908008692 active site 862908008693 KMSKS motif; other site 862908008694 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 862908008695 tRNA binding surface [nucleotide binding]; other site 862908008696 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 862908008697 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862908008698 PS00338 Somatotropin, prolactin and related hormones signature 2. 862908008699 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 6.9e-100 862908008700 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 862908008701 1 probable transmembrane helix predicted for BMS2340 by TMHMM2.0 at aa 20-42 862908008702 Signal peptide predicted for BMS2340 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.878 between residues 34 and 35 862908008703 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908008704 active site 862908008705 PS00134 Serine proteases, trypsin family, histidine active site. 862908008706 Signal peptide predicted for BMS2341 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.314 between residues 22 and 23 862908008707 PilZ domain; Region: PilZ; pfam07238 862908008708 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 862908008709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862908008710 HMMPfam hit to PF00326, Peptidase S9, prolyl oligopeptidase active site region, score 8.7e-41 862908008711 Signal peptide predicted for BMS2343 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.521 between residues 24 and 25 862908008712 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908008713 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 862908008714 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008715 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 862908008716 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 862908008717 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908008718 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 9.4e-13 862908008719 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908008720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008721 active site 862908008722 phosphorylation site [posttranslational modification] 862908008723 intermolecular recognition site; other site 862908008724 dimerization interface [polypeptide binding]; other site 862908008725 HMMPfam hit to PF00072, Response regulator receiver, score 6.8e-30 862908008726 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 862908008727 hydrophobic ligand binding site; other site 862908008728 Signal peptide predicted for BMS2348 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.657 between residues 24 and 25 862908008729 Putative ParB-like nuclease; Region: ParBc_2; cl17538 862908008730 Signal peptide predicted for BMS2349 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.762 between residues 36 and 37 862908008731 1 probable transmembrane helix predicted for BMS2349 by TMHMM2.0 at aa 13-35 862908008732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908008733 active site 862908008734 HMMPfam hit to PF01026, TatD-related deoxyribonuclease, score 1.1e-16 862908008735 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008736 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 862908008737 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 862908008738 putative ATP binding site [chemical binding]; other site 862908008739 putative substrate interface [chemical binding]; other site 862908008740 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 5.2e-37 862908008741 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 862908008742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908008743 FeS/SAM binding site; other site 862908008744 HMMPfam hit to PF04055, Radical SAM, score 1.8e-09 862908008745 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862908008746 active site 862908008747 HMMPfam hit to PF00089, Peptidase S1, chymotrypsin, score 1.9e-05 862908008748 PS00134 Serine proteases, trypsin family, histidine active site. 862908008749 PS00673 Serine proteases, V8 family, serine active site. 862908008750 2 probable transmembrane helices predicted for BMS2355 by TMHMM2.0 at aa 58-75 and 85-107 862908008751 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 862908008752 Peptidase family U32; Region: Peptidase_U32; pfam01136 862908008753 Collagenase; Region: DUF3656; pfam12392 862908008754 Peptidase family U32; Region: Peptidase_U32; cl03113 862908008755 HMMPfam hit to PF01136, Peptidase U32, score 1.6e-87 862908008756 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008757 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 862908008758 HMMPfam hit to PF02129, Peptidase S15, score 3.5e-07 862908008759 Signal peptide predicted for BMS2358 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.614 between residues 19 and 20 862908008760 Signal peptide predicted for BMS2359 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.832 between residues 20 and 21 862908008761 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 862908008762 Signal peptide predicted for BMS2360 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.772 between residues 16 and 17 862908008763 Signal peptide predicted for BMS2361 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.940 between residues 16 and 17 862908008764 Signal peptide predicted for BMS2362 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.630 between residues 24 and 25 862908008765 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 862908008766 Signal peptide predicted for BMS2363 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.415 between residues 40 and 41 862908008767 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862908008768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008769 active site 862908008770 phosphorylation site [posttranslational modification] 862908008771 intermolecular recognition site; other site 862908008772 dimerization interface [polypeptide binding]; other site 862908008773 HMMPfam hit to PF00072, Response regulator receiver, score 1.6e-05 862908008774 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908008775 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 862908008776 dimer interface [polypeptide binding]; other site 862908008777 FMN binding site [chemical binding]; other site 862908008778 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 862908008779 dimer interface [polypeptide binding]; other site 862908008780 HMMPfam hit to PF00881, Nitroreductase, score 1.9e-30 862908008781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908008782 putative substrate translocation pore; other site 862908008783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862908008784 Signal peptide predicted for BMS2370 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.742 between residues 22 and 23 862908008785 HMMPfam hit to PF07690, , score 7.5e-19 862908008786 10 probable transmembrane helices predicted for BMS2370 by TMHMM2.0 at aa 41-60, 73-95, 99-121, 133-155, 165-182, 203-225, 240-259, 279-301, 321-342 and 349-371 862908008787 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862908008788 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908008789 active site 862908008790 metal binding site [ion binding]; metal-binding site 862908008791 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908008792 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908008793 HMMPfam hit to PF00149, Metallophosphoesterase, score 4.9e-13 862908008794 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862908008795 Signal peptide predicted for BMS2372 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.264 between residues 23 and 24 862908008796 Endonuclease I; Region: Endonuclease_1; cl01003 862908008797 Signal peptide predicted for BMS2373 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.988 between residues 41 and 42 862908008798 HMMPfam hit to PF04231, Endonuclease I, score 3.3e-14 862908008799 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862908008800 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 862908008801 peptide binding site [polypeptide binding]; other site 862908008802 Signal peptide predicted for BMS2374 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.639 between residues 19 and 20 862908008803 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.5e-94 862908008804 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 862908008805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862908008806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908008807 dimer interface [polypeptide binding]; other site 862908008808 conserved gate region; other site 862908008809 putative PBP binding loops; other site 862908008810 ABC-ATPase subunit interface; other site 862908008811 7 probable transmembrane helices predicted for BMS2375 by TMHMM2.0 at aa 10-32, 99-121, 136-158, 165-184, 199-221, 260-282 and 311-333 862908008812 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.1e-52 862908008813 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908008814 dipeptide transporter; Provisional; Region: PRK10913 862908008815 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862908008816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908008817 dimer interface [polypeptide binding]; other site 862908008818 conserved gate region; other site 862908008819 putative PBP binding loops; other site 862908008820 ABC-ATPase subunit interface; other site 862908008821 6 probable transmembrane helices predicted for BMS2376 by TMHMM2.0 at aa 25-47, 94-116, 128-150, 155-174, 195-217 and 259-281 862908008822 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-51 862908008823 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862908008824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862908008825 Walker A/P-loop; other site 862908008826 ATP binding site [chemical binding]; other site 862908008827 Q-loop/lid; other site 862908008828 ABC transporter signature motif; other site 862908008829 Walker B; other site 862908008830 D-loop; other site 862908008831 H-loop/switch region; other site 862908008832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862908008833 HMMPfam hit to PF00005, ABC transporter, score 3.7e-55 862908008834 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008835 PS00211 ABC transporters family signature. 862908008836 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862908008837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862908008838 Walker A/P-loop; other site 862908008839 ATP binding site [chemical binding]; other site 862908008840 Q-loop/lid; other site 862908008841 ABC transporter signature motif; other site 862908008842 Walker B; other site 862908008843 D-loop; other site 862908008844 H-loop/switch region; other site 862908008845 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 862908008846 HMMPfam hit to PF00005, ABC transporter, score 1.6e-60 862908008847 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008848 PS00211 ABC transporters family signature. 862908008849 Signal peptide predicted for BMS2379 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.988 between residues 56 and 57 862908008850 1 probable transmembrane helix predicted for BMS2379 by TMHMM2.0 at aa 40-57 862908008851 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908008852 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 862908008853 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 862908008854 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 1.7e-193 862908008855 Signal peptide predicted for BMS2383 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.787 between residues 20 and 21 862908008856 PBP superfamily domain; Region: PBP_like_2; cl17296 862908008857 Signal peptide predicted for BMS2384 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 862908008858 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.6e-16 862908008859 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 862908008860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908008861 dimer interface [polypeptide binding]; other site 862908008862 conserved gate region; other site 862908008863 putative PBP binding loops; other site 862908008864 ABC-ATPase subunit interface; other site 862908008865 6 probable transmembrane helices predicted for BMS2385 by TMHMM2.0 at aa 48-70, 90-121, 133-155, 175-197, 266-288 and 303-325 862908008866 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-13 862908008867 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908008868 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 862908008869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908008870 dimer interface [polypeptide binding]; other site 862908008871 conserved gate region; other site 862908008872 putative PBP binding loops; other site 862908008873 ABC-ATPase subunit interface; other site 862908008874 Signal peptide predicted for BMS2386 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.710 between residues 38 and 39 862908008875 6 probable transmembrane helices predicted for BMS2386 by TMHMM2.0 at aa 12-34, 71-93, 106-128, 133-152, 180-202 and 251-273 862908008876 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.5e-26 862908008877 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908008878 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 862908008879 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 862908008880 Walker A/P-loop; other site 862908008881 ATP binding site [chemical binding]; other site 862908008882 Q-loop/lid; other site 862908008883 ABC transporter signature motif; other site 862908008884 Walker B; other site 862908008885 D-loop; other site 862908008886 H-loop/switch region; other site 862908008887 HMMPfam hit to PF00005, ABC transporter, score 1.5e-59 862908008888 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008889 PS00211 ABC transporters family signature. 862908008890 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862908008891 PhoU domain; Region: PhoU; pfam01895 862908008892 PhoU domain; Region: PhoU; pfam01895 862908008893 HMMPfam hit to PF01895, PhoU, score 2.8e-18 862908008894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908008895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908008896 active site 862908008897 phosphorylation site [posttranslational modification] 862908008898 intermolecular recognition site; other site 862908008899 dimerization interface [polypeptide binding]; other site 862908008900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908008901 DNA binding site [nucleotide binding] 862908008902 HMMPfam hit to PF00072, Response regulator receiver, score 9.2e-28 862908008903 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.1e-18 862908008904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862908008905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908008906 dimer interface [polypeptide binding]; other site 862908008907 phosphorylation site [posttranslational modification] 862908008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908008909 ATP binding site [chemical binding]; other site 862908008910 Mg2+ binding site [ion binding]; other site 862908008911 G-X-G motif; other site 862908008912 2 probable transmembrane helices predicted for BMS2390 by TMHMM2.0 at aa 34-56 and 188-210 862908008913 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 4e-17 862908008914 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.7e-36 862908008915 Signal peptide predicted for BMS2391 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.963 between residues 18 and 19 862908008916 Signal peptide predicted for BMS2392 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 862908008917 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 862908008918 30S subunit binding site; other site 862908008919 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 862908008920 3 probable transmembrane helices predicted for BMS2394 by TMHMM2.0 at aa 13-35, 90-112 and 127-149 862908008921 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 9.8e-26 862908008922 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 862908008923 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 862908008924 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 4.3e-16 862908008925 1 probable transmembrane helix predicted for BMS2395 by TMHMM2.0 at aa 13-32 862908008926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908008927 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 862908008928 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 7e-24 862908008929 PS00284 Serpins signature. 862908008930 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908008931 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908008932 catalytic residue [active] 862908008933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862908008934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862908008935 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 5e-13 862908008936 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.7e-16 862908008937 HMMPfam hit to PF01464, SLT, score 8.5e-18 862908008938 Signal peptide predicted for BMS2397 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.941 between residues 24 and 25 862908008939 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908008940 Signal peptide predicted for BMS2398 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.536 between residues 27 and 28 862908008941 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 862908008942 Signal peptide predicted for BMS2399 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.857 between residues 23 and 24 862908008943 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008944 PS00881 Protein splicing signature. 862908008945 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 862908008946 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 862908008947 active site 862908008948 DnaJ domain; Region: DnaJ; pfam00226 862908008949 1 probable transmembrane helix predicted for BMS2401 by TMHMM2.0 at aa 32-54 862908008950 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 0.013 862908008951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908008952 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862908008953 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862908008954 putative active site [active] 862908008955 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 5.3e-08 862908008956 PS00216 Sugar transport proteins signature 1. 862908008957 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 862908008958 active site 862908008959 Signal peptide predicted for BMS2404 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.433 between residues 18 and 19 862908008960 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908008961 HMMPfam hit to PF00112, Peptidase C1A, papain, score 8.2e-07 862908008962 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 862908008963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908008964 Walker A motif; other site 862908008965 ATP binding site [chemical binding]; other site 862908008966 Walker B motif; other site 862908008967 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 6.1e-18 862908008968 PS00017 ATP/GTP-binding site motif A (P-loop). 862908008969 PS00662 Bacterial type II secretion system protein E signature. 862908008970 RDD family; Region: RDD; pfam06271 862908008971 HMMPfam hit to PF06271, RDD, score 3.3e-16 862908008972 3 probable transmembrane helices predicted for BMS2406 by TMHMM2.0 at aa 80-102, 122-144 and 173-195 862908008973 carboxy-terminal protease; Provisional; Region: PRK11186 862908008974 PDZ domain (Also known as DHR or GLGF); Region: PDZ; pfam00595 862908008975 protein binding site [polypeptide binding]; other site 862908008976 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862908008977 Catalytic dyad [active] 862908008978 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 862908008979 HMMPfam hit to PF03572, Peptidase S41, score 3.2e-60 862908008980 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2e-14 862908008981 Signal peptide predicted for BMS2408 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 862908008982 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 862908008983 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 862908008984 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 862908008985 Ligand Binding Site [chemical binding]; other site 862908008986 HMMPfam hit to PF02568, Thiamine biosynthesis protein, score 1.5e-72 862908008987 HMMPfam hit to PF02926, THUMP, score 3.6e-16 862908008988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908008989 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862908008990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908008991 catalytic residue [active] 862908008992 HMMPfam hit to PF00266, Aminotransferase, class V, score 4.1e-37 862908008993 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 862908008994 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862908008995 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 862908008996 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862908008997 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 862908008998 Domain interface; other site 862908008999 Peptide binding site; other site 862908009000 Active site tetrad [active] 862908009001 HMMPfam hit to PF03572, Peptidase S41, score 6.9e-27 862908009002 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 862908009003 HMMPfam hit to PF05618, Protein of unknown function DUF785, score 7.5e-35 862908009004 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 862908009005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908009006 TrkA-C domain; Region: TrkA_C; pfam02080 862908009007 HMMPfam hit to PF02080, TrkA-C, score 4.1e-08 862908009008 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 862908009009 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 862908009010 putative active site [active] 862908009011 Zn binding site [ion binding]; other site 862908009012 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 4.2e-70 862908009013 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 862908009014 Signal peptide predicted for BMS2415 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.952 between residues 19 and 20 862908009015 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908009016 Signal peptide predicted for BMS2416 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21 862908009017 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 862908009018 Signal peptide predicted for BMS2417 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 18 and 19 862908009019 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 862908009020 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 862908009021 dimerization interface [polypeptide binding]; other site 862908009022 DPS ferroxidase diiron center [ion binding]; other site 862908009023 ion pore; other site 862908009024 HMMPfam hit to PF00210, Ferritin and Dps, score 1.2e-26 862908009025 PS00818 Dps protein family signature 1. 862908009026 PS00819 Dps protein family signature 2. 862908009027 2 probable transmembrane helices predicted for BMS2419 by TMHMM2.0 at aa 5-27 and 47-69 862908009028 Signal peptide predicted for BMS2419 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.526 between residues 23 and 24 862908009029 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 862908009030 Fatty acid desaturase; Region: FA_desaturase; pfam00487 862908009031 Di-iron ligands [ion binding]; other site 862908009032 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 862908009033 HMMPfam hit to PF00487, Fatty acid desaturase, score 2.1e-56 862908009034 2 probable transmembrane helices predicted for BMS2421 by TMHMM2.0 at aa 4-26 and 119-141 862908009035 Signal peptide predicted for BMS2421 by SignalP 2.0 HMM (Signal peptide probability 0.838) with cleavage site probability 0.456 between residues 20 and 21 862908009036 aconitate hydratase; Validated; Region: PRK09277 862908009037 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 862908009038 substrate binding site [chemical binding]; other site 862908009039 ligand binding site [chemical binding]; other site 862908009040 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 862908009041 substrate binding site [chemical binding]; other site 862908009042 HMMPfam hit to PF00694, Aconitate hydratase, C-terminal, score 4.1e-59 862908009043 HMMPfam hit to PF00330, Aconitate hydratase, N-terminal, score 1.2e-250 862908009044 PS01244 Aconitase family signature 2. 862908009045 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009046 PS00450 Aconitase family signature 1. 862908009047 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908009049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009050 active site 862908009051 phosphorylation site [posttranslational modification] 862908009052 intermolecular recognition site; other site 862908009053 dimerization interface [polypeptide binding]; other site 862908009054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908009055 DNA binding site [nucleotide binding] 862908009056 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.4e-10 862908009057 HMMPfam hit to PF00072, Response regulator receiver, score 1.6e-06 862908009058 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0068 862908009059 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 862908009060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908009061 S-adenosylmethionine binding site [chemical binding]; other site 862908009062 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862908009063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908009064 S-adenosylmethionine binding site [chemical binding]; other site 862908009065 Protein of unknown function (DUF454); Region: DUF454; cl01063 862908009066 Signal peptide predicted for BMS2427 by SignalP 2.0 HMM (Signal peptide probability 0.799) with cleavage site probability 0.661 between residues 44 and 45 862908009067 3 probable transmembrane helices predicted for BMS2427 by TMHMM2.0 at aa 10-32, 79-96 and 100-119 862908009068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908009069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908009070 S-adenosylmethionine binding site [chemical binding]; other site 862908009071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 862908009072 Protein of unknown function, DUF482; Region: DUF482; pfam04339 862908009073 HMMPfam hit to PF04339, Protein of unknown function DUF482, score 1.3e-96 862908009074 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 862908009075 catalytic triad [active] 862908009076 active site nucleophile [active] 862908009077 HMMPfam hit to PF03575, Peptidase S51, dipeptidase E, score 8.5e-09 862908009078 serine/threonine protein kinase; Provisional; Region: PRK11768 862908009079 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 862908009080 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 4.1e-18 862908009081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908009082 Coenzyme A binding pocket [chemical binding]; other site 862908009083 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.2e-12 862908009084 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 862908009085 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 862908009086 active site 862908009087 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin type, score 4.6e-43 862908009088 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 862908009089 Signal peptide predicted for BMS2435 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.992 between residues 19 and 20 862908009090 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862908009091 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 862908009092 putative catalytic residue [active] 862908009093 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.4e-18 862908009094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908009095 Zn2+ binding site [ion binding]; other site 862908009096 Mg2+ binding site [ion binding]; other site 862908009097 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 6.4e-05 862908009098 ATP-dependent helicase HepA; Validated; Region: PRK04914 862908009099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908009100 ATP binding site [chemical binding]; other site 862908009101 putative Mg++ binding site [ion binding]; other site 862908009102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908009103 nucleotide binding region [chemical binding]; other site 862908009104 ATP-binding site [chemical binding]; other site 862908009105 HMMPfam hit to PF00271, Helicase, C-terminal, score 6.9e-14 862908009106 HMMPfam hit to PF00176, SNF2-related, score 4e-11 862908009107 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.5e-06 862908009108 1 probable transmembrane helix predicted for BMS2440 by TMHMM2.0 at aa 34-53 862908009109 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009110 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862908009111 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908009112 Magnesium ion binding site [ion binding]; other site 862908009113 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 2.1e-18 862908009114 1 probable transmembrane helix predicted for BMS2443 by TMHMM2.0 at aa 5-27 862908009115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862908009116 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0023 862908009117 Signal peptide predicted for BMS2445 by SignalP 2.0 HMM (Signal peptide probability 0.916) with cleavage site probability 0.599 between residues 48 and 49 862908009118 1 probable transmembrane helix predicted for BMS2445 by TMHMM2.0 at aa 15-37 862908009119 Response regulator receiver domain; Region: Response_reg; pfam00072 862908009120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009121 active site 862908009122 phosphorylation site [posttranslational modification] 862908009123 intermolecular recognition site; other site 862908009124 dimerization interface [polypeptide binding]; other site 862908009125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908009126 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 862908009127 phosphorylation site [posttranslational modification] 862908009128 dimer interface [polypeptide binding]; other site 862908009129 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0086 862908009130 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-31 862908009131 seryl-tRNA synthetase; Provisional; Region: PRK05431 862908009132 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 862908009133 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 862908009134 dimer interface [polypeptide binding]; other site 862908009135 active site 862908009136 motif 1; other site 862908009137 motif 2; other site 862908009138 motif 3; other site 862908009139 HMMPfam hit to PF00587, tRNA synthetases, class-II (G, H, P and S), score 1.4e-45 862908009140 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908009141 HMMPfam hit to PF02403, Seryl-tRNA synthetase, class IIa, score 8.2e-24 862908009142 Response regulator receiver domain; Region: Response_reg; pfam00072 862908009143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009144 active site 862908009145 phosphorylation site [posttranslational modification] 862908009146 intermolecular recognition site; other site 862908009147 dimerization interface [polypeptide binding]; other site 862908009148 HMMPfam hit to PF00072, Response regulator receiver, score 5.2e-12 862908009149 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 862908009150 Domain of unknown function DUF20; Region: UPF0118; pfam01594 862908009151 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 4.2e-34 862908009152 8 probable transmembrane helices predicted for BMS2451 by TMHMM2.0 at aa 7-26, 30-49, 61-83, 141-163, 184-206, 211-233, 240-262 and 282-304 862908009153 Signal peptide predicted for BMS2453 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.853 between residues 31 and 32 862908009154 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 862908009155 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 3.2e-85 862908009156 7 probable transmembrane helices predicted for BMS2454 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 119-141, 176-195, 202-219 and 229-251 862908009157 PS01311 Prolipoprotein diacylglyceryl transferase signature. 862908009158 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 862908009159 1 probable transmembrane helix predicted for BMS2455 by TMHMM2.0 at aa 5-27 862908009160 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862908009161 HMMPfam hit to PF04055, Radical SAM, score 5.2e-17 862908009162 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908009163 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908009164 active site 862908009165 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.7e-21 862908009166 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009167 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 862908009168 active site 862908009169 dimer interfaces [polypeptide binding]; other site 862908009170 catalytic residues [active] 862908009171 HMMPfam hit to PF02142, Methylglyoxal synthase-like, score 5.8e-25 862908009172 PS01335 Methylglyoxal synthase active site. 862908009173 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862908009174 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.2e-08 862908009175 PS00196 Type-1 copper (blue) proteins signature. 862908009176 tellurium resistance terB-like protein; Region: terB_like; cl11965 862908009177 metal binding site [ion binding]; metal-binding site 862908009178 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 862908009179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908009180 motif II; other site 862908009181 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.5e-12 862908009182 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 862908009183 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 862908009184 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 862908009185 Signal peptide predicted for BMS2465 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.819 between residues 16 and 17 862908009186 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 2.6e-40 862908009187 PS00775 Glycosyl hydrolases family 3 active site. 862908009188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009189 active site 862908009190 phosphorylation site [posttranslational modification] 862908009191 intermolecular recognition site; other site 862908009192 HMMPfam hit to PF00072, Response regulator receiver, score 4.7e-06 862908009193 FOG: CBS domain [General function prediction only]; Region: COG0517 862908009194 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 862908009195 HMMPfam hit to PF00571, CBS, score 2.8e-12 862908009196 HMMPfam hit to PF00571, CBS, score 3.7e-09 862908009197 Signal peptide predicted for BMS2469 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.930 between residues 20 and 21 862908009198 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862908009199 active site 862908009200 Zn binding site [ion binding]; other site 862908009201 Signal peptide predicted for BMS2471 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.859 between residues 18 and 19 862908009202 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 3.2e-31 862908009203 PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 862908009204 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 862908009205 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862908009206 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908009207 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009208 Signal peptide predicted for BMS2473 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.796 between residues 16 and 17 862908009209 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 862908009210 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 862908009211 Sulfate transporter family; Region: Sulfate_transp; pfam00916 862908009212 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 862908009213 Signal peptide predicted for BMS2474 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.452 between residues 33 and 34 862908009214 12 probable transmembrane helices predicted for BMS2474 by TMHMM2.0 at aa 17-39, 43-60, 65-82, 87-109, 114-136, 156-173, 180-199, 231-253, 273-295, 305-322, 327-349 and 369-391 862908009215 HMMPfam hit to PF00916, Sulphate transporter, score 2.5e-74 862908009216 HMMPfam hit to PF01740, Sulfate transporter/antisigma-factor antagonist STAS, score 8.5e-05 862908009217 Signal peptide predicted for BMS2475 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 17 and 18 862908009218 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 862908009219 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 862908009220 putative active site [active] 862908009221 Zn binding site [ion binding]; other site 862908009222 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 2.4e-39 862908009223 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 862908009224 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908009225 SET domain; Region: SET; pfam00856 862908009226 SET domain; Region: SET; pfam00856 862908009227 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 862908009228 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 862908009229 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 2.3e-18 862908009230 6 probable transmembrane helices predicted for BMS2481 by TMHMM2.0 at aa 20-42, 57-74, 87-109, 113-132, 139-161 and 211-233 862908009231 Transcriptional regulator; Region: Transcrip_reg; pfam01709 862908009232 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 3.3e-100 862908009233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862908009234 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862908009235 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.9e-13 862908009236 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 862908009237 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 862908009238 heme-binding site [chemical binding]; other site 862908009239 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 862908009240 FAD binding pocket [chemical binding]; other site 862908009241 FAD binding motif [chemical binding]; other site 862908009242 phosphate binding motif [ion binding]; other site 862908009243 beta-alpha-beta structure motif; other site 862908009244 NAD binding pocket [chemical binding]; other site 862908009245 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 1.2e-16 862908009246 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 8.3e-07 862908009247 HMMPfam hit to PF00042, Globin, score 4.1e-18 862908009248 Predicted transcriptional regulator [Transcription]; Region: COG1959 862908009249 Transcriptional regulator; Region: Rrf2; cl17282 862908009250 HMMPfam hit to PF02082, Protein of unknown function UPF0074, score 2e-37 862908009251 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 862908009252 4 probable transmembrane helices predicted for BMS2487 by TMHMM2.0 at aa 129-151, 180-202, 209-226 and 236-253 862908009253 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 862908009254 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 862908009255 dimer interface [polypeptide binding]; other site 862908009256 active site 862908009257 heme binding site [chemical binding]; other site 862908009258 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 862908009259 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 7.9e-83 862908009260 PS00436 Peroxidases active site signature. 862908009261 PS00435 Peroxidases proximal heme-ligand signature. 862908009262 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 1.4e-99 862908009263 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 862908009264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862908009265 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 4.3e-53 862908009266 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 862908009267 arsenical-resistance protein; Region: acr3; TIGR00832 862908009268 10 probable transmembrane helices predicted for BMS2490 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 121-143, 160-182, 186-208, 228-245, 255-277, 290-312 and 316-338 862908009269 HMMPfam hit to PF01758, Bile acid:sodium symporter, score 1.6e-50 862908009270 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862908009271 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862908009272 active site 862908009273 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein phosphatase, score 2e-22 862908009274 Signal peptide predicted for BMS2491 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.759 between residues 19 and 20 862908009275 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 862908009276 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 862908009277 DNA binding residues [nucleotide binding] 862908009278 dimer interface [polypeptide binding]; other site 862908009279 metal binding site [ion binding]; metal-binding site 862908009280 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.1e-10 862908009281 Signal peptide predicted for BMS2493 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.996 between residues 27 and 28 862908009282 Signal peptide predicted for BMS2494 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 20 and 21 862908009283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 862908009284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862908009285 active site 862908009286 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 6.4e-15 862908009287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908009288 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862908009289 putative active site [active] 862908009290 heme pocket [chemical binding]; other site 862908009291 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862908009292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908009293 putative active site [active] 862908009294 heme pocket [chemical binding]; other site 862908009295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908009296 dimer interface [polypeptide binding]; other site 862908009297 phosphorylation site [posttranslational modification] 862908009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908009299 ATP binding site [chemical binding]; other site 862908009300 Mg2+ binding site [ion binding]; other site 862908009301 G-X-G motif; other site 862908009302 Response regulator receiver domain; Region: Response_reg; pfam00072 862908009303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009304 active site 862908009305 phosphorylation site [posttranslational modification] 862908009306 intermolecular recognition site; other site 862908009307 dimerization interface [polypeptide binding]; other site 862908009308 HMMPfam hit to PF00072, Response regulator receiver, score 3.2e-25 862908009309 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.2e-38 862908009310 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.7e-26 862908009311 HMMPfam hit to PF00989, PAS, score 2.5e-07 862908009312 Cupin domain; Region: Cupin_2; cl17218 862908009313 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862908009315 HMMPfam hit to PF00072, Response regulator receiver, score 1.8e-10 862908009316 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.4e-31 862908009317 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.00055 862908009318 1 probable transmembrane helix predicted for BMS2500 by TMHMM2.0 at aa 20-42 862908009319 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 862908009320 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 862908009321 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.00027 862908009322 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908009323 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 862908009324 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 862908009325 domain interfaces; other site 862908009326 active site 862908009327 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862908009328 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.0045 862908009329 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.00039 862908009330 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908009331 HMMPfam hit to PF02887, Pyruvate kinase, score 8.4e-08 862908009332 HMMPfam hit to PF00224, Pyruvate kinase, score 3.5e-145 862908009333 PS00110 Pyruvate kinase active site signature. 862908009334 Thioredoxin; Region: Thioredoxin_4; pfam13462 862908009335 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862908009336 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.7e-26 862908009337 Signal peptide predicted for BMS2504 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.368 between residues 30 and 31 862908009338 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908009339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908009340 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 862908009341 Walker A/P-loop; other site 862908009342 ATP binding site [chemical binding]; other site 862908009343 Q-loop/lid; other site 862908009344 ABC transporter signature motif; other site 862908009345 Walker B; other site 862908009346 D-loop; other site 862908009347 H-loop/switch region; other site 862908009348 HMMPfam hit to PF00005, ABC transporter, score 2.5e-22 862908009349 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009350 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 0.00013 862908009351 5 probable transmembrane helices predicted for BMS2505 by TMHMM2.0 at aa 20-39, 54-76, 136-158, 163-182 and 258-280 862908009352 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908009353 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908009354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908009355 Walker A/P-loop; other site 862908009356 ATP binding site [chemical binding]; other site 862908009357 Q-loop/lid; other site 862908009358 ABC transporter signature motif; other site 862908009359 Walker B; other site 862908009360 D-loop; other site 862908009361 H-loop/switch region; other site 862908009362 HMMPfam hit to PF00005, ABC transporter, score 1.9e-25 862908009363 PS00211 ABC transporters family signature. 862908009364 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009365 6 probable transmembrane helices predicted for BMS2506 by TMHMM2.0 at aa 20-39, 61-83, 128-150, 160-179, 240-262 and 272-294 862908009366 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 0.00011 862908009367 Signal peptide predicted for BMS2507 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 17 and 18 862908009368 PS00190 Cytochrome c family heme-binding site signature. 862908009369 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 862908009370 Signal peptide predicted for BMS2508 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.894 between residues 18 and 19 862908009371 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 862908009372 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 862908009373 homodimer interface [polypeptide binding]; other site 862908009374 substrate-cofactor binding pocket; other site 862908009375 catalytic residue [active] 862908009376 HMMPfam hit to PF01063, Aminotransferase, class IV, score 1.3e-97 862908009377 PS00770 Aminotransferases class-IV signature. 862908009378 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 862908009379 11 probable transmembrane helices predicted for BMS2510 by TMHMM2.0 at aa 4-23, 43-65, 99-121, 134-168, 183-205, 217-239, 269-291, 312-331, 341-363, 376-398 and 413-435 862908009380 HMMPfam hit to PF07399, Protein of unknown function DUF1504, score 2.1e-165 862908009381 PS00012 Phosphopantetheine attachment site. 862908009382 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 862908009383 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 862908009384 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 862908009385 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 862908009386 active site 862908009387 substrate binding site [chemical binding]; other site 862908009388 metal binding site [ion binding]; metal-binding site 862908009389 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 8e-54 862908009390 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 862908009391 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 0.00068 862908009392 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 0.055 862908009393 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C terminal, score 0.0096 862908009394 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 862908009395 Ligand Binding Site [chemical binding]; other site 862908009396 HMMPfam hit to PF06508, ExsB, score 1.3e-30 862908009397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908009398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908009399 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 862908009400 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 862908009401 quinone interaction residues [chemical binding]; other site 862908009402 active site 862908009403 catalytic residues [active] 862908009404 FMN binding site [chemical binding]; other site 862908009405 substrate binding site [chemical binding]; other site 862908009406 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 1.5e-74 862908009407 PS00911 Dihydroorotate dehydrogenase signature 1. 862908009408 Signal peptide predicted for BMS2516 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.471 between residues 32 and 33 862908009409 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009410 Signal peptide predicted for BMS2517 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.941 between residues 20 and 21 862908009411 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 862908009412 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 862908009413 active site 862908009414 PHP Thumb interface [polypeptide binding]; other site 862908009415 metal binding site [ion binding]; metal-binding site 862908009416 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 862908009417 generic binding surface I; other site 862908009418 generic binding surface II; other site 862908009419 HMMPfam hit to PF01336, OB-fold nucleic acid binding, score 5.6e-08 862908009420 HMMPfam hit to PF07733, , score 1.1e-270 862908009421 HMMPfam hit to PF02811, PHP, C-terminal, score 4.7e-36 862908009422 HMMPfam hit to PF02231, Phosphoesterase PHP, N-terminal, score 3.2e-30 862908009423 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 862908009424 1 probable transmembrane helix predicted for BMS2519 by TMHMM2.0 at aa 4-26 862908009425 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 862908009426 Signal peptide predicted for BMS2521 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.587 between residues 20 and 21 862908009427 GMP synthase; Reviewed; Region: guaA; PRK00074 862908009428 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 862908009429 AMP/PPi binding site [chemical binding]; other site 862908009430 candidate oxyanion hole; other site 862908009431 catalytic triad [active] 862908009432 potential glutamine specificity residues [chemical binding]; other site 862908009433 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 862908009434 ATP Binding subdomain [chemical binding]; other site 862908009435 Ligand Binding sites [chemical binding]; other site 862908009436 Dimerization subdomain; other site 862908009437 HMMPfam hit to PF00958, GMP synthase, C-terminal, score 8.3e-64 862908009438 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.9e-37 862908009439 PS00442 Glutamine amidotransferases class-I active site. 862908009440 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 862908009441 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862908009442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 862908009443 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 862908009444 active site 862908009445 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 1.5e-195 862908009446 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009447 PS00487 IMP dehydrogenase / GMP reductase signature. 862908009448 HMMPfam hit to PF00571, CBS, score 4.2e-11 862908009449 HMMPfam hit to PF00571, CBS, score 8.3e-12 862908009450 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 862908009451 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 862908009452 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 862908009453 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 862908009454 cobalamin binding residues [chemical binding]; other site 862908009455 putative BtuC binding residues; other site 862908009456 dimer interface [polypeptide binding]; other site 862908009457 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.5e-05 862908009458 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 862908009459 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 862908009460 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 862908009461 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862908009462 Signal peptide predicted for BMS2527 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.618 between residues 26 and 27 862908009463 8 probable transmembrane helices predicted for BMS2527 by TMHMM2.0 at aa 349-371, 392-414, 429-451, 478-500, 505-527, 548-567, 571-593 and 600-619 862908009464 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 862908009465 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 862908009466 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 862908009467 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal, score 1.4e-53 862908009468 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal, score 1.9e-20 862908009469 1 probable transmembrane helix predicted for BMS2528 by TMHMM2.0 at aa 5-24 862908009470 Signal peptide predicted for BMS2528 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.951 between residues 23 and 24 862908009471 Protein of unknown function (DUF493); Region: DUF493; pfam04359 862908009472 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862908009473 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862908009474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 862908009475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908009476 dimer interface [polypeptide binding]; other site 862908009477 phosphorylation site [posttranslational modification] 862908009478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908009479 ATP binding site [chemical binding]; other site 862908009480 Mg2+ binding site [ion binding]; other site 862908009481 G-X-G motif; other site 862908009482 2 probable transmembrane helices predicted for BMS2531 by TMHMM2.0 at aa 10-32 and 270-292 862908009483 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.3e-12 862908009484 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9e-27 862908009485 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 862908009486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908009487 active site 862908009488 motif I; other site 862908009489 motif II; other site 862908009490 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 862908009491 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 862908009492 HMMPfam hit to PF00793, DAHP synthetase I/KDSA superfamily, score 1.3e-84 862908009493 CTP synthetase; Validated; Region: pyrG; PRK05380 862908009494 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 862908009495 Catalytic site [active] 862908009496 active site 862908009497 UTP binding site [chemical binding]; other site 862908009498 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 862908009499 active site 862908009500 putative oxyanion hole; other site 862908009501 catalytic triad [active] 862908009502 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.6e-51 862908009503 PS00442 Glutamine amidotransferases class-I active site. 862908009504 HMMPfam hit to PF06418, CTP synthase, score 1.6e-191 862908009505 Signal peptide predicted for BMS2534 by SignalP 2.0 HMM (Signal peptide probability 0.930) with cleavage site probability 0.485 between residues 31 and 32 862908009506 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 862908009507 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 862908009508 Ligand binding site; other site 862908009509 oligomer interface; other site 862908009510 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 6e-21 862908009511 Predicted membrane protein [Function unknown]; Region: COG4905 862908009512 Signal peptide predicted for BMS2536 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.956 between residues 25 and 26 862908009513 Outer membrane efflux protein; Region: OEP; pfam02321 862908009514 Outer membrane efflux protein; Region: OEP; pfam02321 862908009515 Signal peptide predicted for BMS2537 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 862908009516 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.00098 862908009517 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0024 862908009518 Signal peptide predicted for BMS2538 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.965 between residues 20 and 21 862908009519 adenylosuccinate lyase; Provisional; Region: PRK07492 862908009520 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 862908009521 tetramer interface [polypeptide binding]; other site 862908009522 active site 862908009523 HMMPfam hit to PF00206, Fumarate lyase, score 1.9e-28 862908009524 PS00163 Fumarate lyases signature. 862908009525 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 862908009526 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 862908009527 Substrate binding site; other site 862908009528 Cupin domain; Region: Cupin_2; cl17218 862908009529 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.7e-55 862908009530 Sporulation related domain; Region: SPOR; pfam05036 862908009531 1 probable transmembrane helix predicted for BMS2541 by TMHMM2.0 at aa 15-34 862908009532 1 probable transmembrane helix predicted for BMS2543 by TMHMM2.0 at aa 15-34 862908009533 Signal peptide predicted for BMS2544 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.616 between residues 27 and 28 862908009534 1 probable transmembrane helix predicted for BMS2544 by TMHMM2.0 at aa 13-31 862908009535 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 862908009536 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908009537 Walker A motif; other site 862908009538 ATP binding site [chemical binding]; other site 862908009539 Walker B motif; other site 862908009540 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 5.2e-11 862908009541 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009542 aspartate kinase; Validated; Region: PRK08373 862908009543 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 862908009544 nucleotide binding site [chemical binding]; other site 862908009545 substrate binding site [chemical binding]; other site 862908009546 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 8.9e-40 862908009547 PS00324 Aspartokinase signature. 862908009548 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 862908009549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908009550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908009551 ABC transporter; Region: ABC_tran_2; pfam12848 862908009552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862908009553 HMMPfam hit to PF00005, ABC transporter, score 2.8e-48 862908009554 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009555 HMMPfam hit to PF00005, ABC transporter, score 3.4e-47 862908009556 PS00211 ABC transporters family signature. 862908009557 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009558 3 probable transmembrane helices predicted for BMS2552 by TMHMM2.0 at aa 89-111, 126-148 and 244-266 862908009559 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 862908009560 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 862908009561 putative RNA binding site [nucleotide binding]; other site 862908009562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908009563 S-adenosylmethionine binding site [chemical binding]; other site 862908009564 Signal peptide predicted for BMS2555 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.962 between residues 18 and 19 862908009565 Signal peptide predicted for BMS2556 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.613 between residues 18 and 19 862908009566 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 862908009567 4Fe-4S binding domain; Region: Fer4; cl02805 862908009568 4Fe-4S binding domain; Region: Fer4; cl02805 862908009569 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 1.1e-05 862908009570 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908009571 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 4.3e-05 862908009572 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908009573 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 862908009574 NADH dehydrogenase subunit D; Validated; Region: PRK06075 862908009575 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 1.5e-82 862908009576 1 probable transmembrane helix predicted for BMS2559 by TMHMM2.0 at aa 127-149 862908009577 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 862908009578 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 2.1e-31 862908009579 PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 862908009580 NADH dehydrogenase subunit B; Validated; Region: PRK06411 862908009581 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 1e-55 862908009582 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908009584 HMMPfam hit to PF07719, , score 0.0063; PF07719, Tetratricopeptide repeat 862908009585 Signal peptide predicted for BMS2564 by SignalP 2.0 HMM (Signal peptide probability 0.826) with cleavage site probability 0.384 between residues 24 and 25 862908009586 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 862908009587 Signal peptide predicted for BMS2565 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.803 between residues 22 and 23 862908009588 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009589 Signal peptide predicted for BMS2566 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.466 between residues 22 and 23 862908009590 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009591 Signal peptide predicted for BMS2567 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.710 between residues 18 and 19 862908009592 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 862908009593 ligand binding site [chemical binding]; other site 862908009594 Signal peptide predicted for BMS2569 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.692 between residues 22 and 23 862908009595 2 probable transmembrane helices predicted for BMS2570 by TMHMM2.0 at aa 34-56 and 86-108 862908009596 PilZ domain; Region: PilZ; pfam07238 862908009597 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 862908009598 Signal peptide predicted for BMS2572 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.388 between residues 25 and 26 862908009599 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009600 2 probable transmembrane helices predicted for BMS2573 by TMHMM2.0 at aa 13-35 and 137-159 862908009601 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 862908009602 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 862908009603 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 862908009604 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, score 1.6e-17 862908009605 Signal peptide predicted for BMS2575 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 20 and 21 862908009606 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862908009607 Signal peptide predicted for BMS2577 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 862908009608 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 0.0023 862908009609 Signal peptide predicted for BMS2578 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.571 between residues 27 and 28 862908009610 PS00036 bZIP transcription factors basic domain signature. 862908009611 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862908009612 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862908009613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862908009614 HMMPfam hit to PF00805, Pentapeptide repeat, score 0.17 862908009615 HMMPfam hit to PF00805, Pentapeptide repeat, score 0.51 862908009616 HMMPfam hit to PF00805, Pentapeptide repeat, score 4.9e-09 862908009617 HAMP domain; Region: HAMP; pfam00672 862908009618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862908009619 PAS domain; Region: PAS_9; pfam13426 862908009620 putative active site [active] 862908009621 heme pocket [chemical binding]; other site 862908009622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908009623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908009624 dimer interface [polypeptide binding]; other site 862908009625 phosphorylation site [posttranslational modification] 862908009626 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 862908009627 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.6e-22 862908009628 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.00035 862908009629 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.0029 862908009630 2 probable transmembrane helices predicted for BMS2580 by TMHMM2.0 at aa 13-35 and 149-171 862908009631 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 862908009632 HMMPfam hit to PF01169, Protein of unknown function UPF0016, score 1.6e-06 862908009633 1 probable transmembrane helix predicted for BMS2581 by TMHMM2.0 at aa 39-61 862908009634 3 probable transmembrane helices predicted for BMS2582 by TMHMM2.0 at aa 28-50, 62-80 and 84-106 862908009635 4 probable transmembrane helices predicted for BMS2583 by TMHMM2.0 at aa 7-29, 33-51, 72-94 and 98-120 862908009636 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009637 Domain of unknown function (DUF368); Region: DUF368; pfam04018 862908009638 6 probable transmembrane helices predicted for BMS2584 by TMHMM2.0 at aa 81-103, 113-131, 143-165, 175-197, 210-232 and 295-312 862908009639 HMMPfam hit to PF04018, Protein of unknown function DUF368, score 5.4e-73 862908009640 DNA topoisomerase I; Validated; Region: PRK06599 862908009641 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 862908009642 active site 862908009643 interdomain interaction site; other site 862908009644 putative metal-binding site [ion binding]; other site 862908009645 nucleotide binding site [chemical binding]; other site 862908009646 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862908009647 domain I; other site 862908009648 DNA binding groove [nucleotide binding] 862908009649 phosphate binding site [ion binding]; other site 862908009650 domain II; other site 862908009651 domain III; other site 862908009652 nucleotide binding site [chemical binding]; other site 862908009653 catalytic site [active] 862908009654 domain IV; other site 862908009655 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862908009656 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 862908009657 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862908009658 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862908009659 HMMPfam hit to PF01396, DNA topoisomerase I, score 0.046 862908009660 HMMPfam hit to PF01396, DNA topoisomerase I, score 2.4e-15 862908009661 HMMPfam hit to PF01396, DNA topoisomerase I, score 0.0044 862908009662 HMMPfam hit to PF01396, DNA topoisomerase I, score 3.3e-06 862908009663 HMMPfam hit to PF01131, DNA topoisomerase I, score 3.4e-147 862908009664 PS00396 Prokaryotic DNA topoisomerase I active site. 862908009665 HMMPfam hit to PF01751, TOPRIM, score 3.3e-30 862908009666 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862908009667 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 1.6e-09 862908009668 Signal peptide predicted for BMS2586 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 862908009669 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908009670 1 probable transmembrane helix predicted for BMS2587 by TMHMM2.0 at aa 13-35 862908009671 Signal peptide predicted for BMS2588 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.739 between residues 22 and 23 862908009672 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009673 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908009674 Signal peptide predicted for BMS2589 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.782 between residues 19 and 20 862908009675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908009676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908009677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908009678 Walker A/P-loop; other site 862908009679 ATP binding site [chemical binding]; other site 862908009680 Q-loop/lid; other site 862908009681 ABC transporter signature motif; other site 862908009682 Walker B; other site 862908009683 D-loop; other site 862908009684 H-loop/switch region; other site 862908009685 HMMPfam hit to PF00005, ABC transporter, score 1.5e-66 862908009686 PS00211 ABC transporters family signature. 862908009687 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009688 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 7.2e-36 862908009689 5 probable transmembrane helices predicted for BMS2590 by TMHMM2.0 at aa 21-43, 69-91, 149-168, 172-191 and 253-275 862908009690 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908009691 putative catalytic site [active] 862908009692 putative metal binding site [ion binding]; other site 862908009693 putative phosphate binding site [ion binding]; other site 862908009694 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 1.2e-06 862908009695 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 862908009696 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 862908009697 catalytic triad [active] 862908009698 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 4e-45 862908009699 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862908009701 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862908009702 HMMPfam hit to PF00753, Beta-lactamase-like, score 8.3e-30 862908009703 Peptidase family M48; Region: Peptidase_M48; pfam01435 862908009704 6 probable transmembrane helices predicted for BMS2595 by TMHMM2.0 at aa 69-91, 106-128, 149-171, 175-197, 293-315 and 330-352 862908009705 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 3.1e-42 862908009706 Signal peptide predicted for BMS2596 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.845 between residues 19 and 20 862908009707 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 862908009708 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862908009709 DNA binding site [nucleotide binding] 862908009710 active site 862908009711 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, score 1.4e-41 862908009712 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 862908009713 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 862908009714 conserved cys residue [active] 862908009715 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7e-06 862908009716 PS00442 Glutamine amidotransferases class-I active site. 862908009717 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 862908009718 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862908009719 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908009720 HMMPfam hit to PF00561, Alpha/beta hydrolase fold, score 4.7e-05 862908009721 Protein of unknown function (DUF525); Region: DUF525; cl01119 862908009722 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 862908009723 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 862908009724 Serine hydrolase (FSH1); Region: FSH1; pfam03959 862908009725 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 2.7e-17 862908009726 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 862908009727 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862908009728 minor groove reading motif; other site 862908009729 helix-hairpin-helix signature motif; other site 862908009730 substrate binding pocket [chemical binding]; other site 862908009731 active site 862908009732 HMMPfam hit to PF00730, HhH-GPD, score 2.4e-20 862908009733 PS01155 Endonuclease III family signature. 862908009734 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.0012 862908009735 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 862908009736 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 7.7e-06 862908009737 PS01313 Lipoate-protein ligase B signature. 862908009738 lipoyl synthase; Provisional; Region: PRK05481 862908009739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 862908009740 FeS/SAM binding site; other site 862908009741 HMMPfam hit to PF04055, Radical SAM, score 5.2e-20 862908009742 PS00190 Cytochrome c family heme-binding site signature. 862908009743 Signal peptide predicted for BMS2610 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.891 between residues 30 and 31 862908009744 Haemolytic domain; Region: Haemolytic; pfam01809 862908009745 HMMPfam hit to PF01809, Protein of unknown function DUF37, score 1.5e-33 862908009746 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 862908009747 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 862908009748 HMMPfam hit to PF02113, Peptidase S13, D-Ala-D-Ala carboxypeptidase C, score 1.8e-19 862908009749 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 862908009750 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 862908009751 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 862908009752 DNA binding residues [nucleotide binding] 862908009753 B12 binding domain; Region: B12-binding_2; pfam02607 862908009754 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862908009755 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 0.00075 862908009756 PS00552 Bacterial regulatory proteins, merR family signature. 862908009757 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 862908009758 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 862908009759 putative NAD(P) binding site [chemical binding]; other site 862908009760 putative active site [active] 862908009761 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 862908009762 putative hydrophobic ligand binding site [chemical binding]; other site 862908009763 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 862908009764 Signal peptide predicted for BMS2617 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.460 between residues 19 and 20 862908009765 PS00213 Lipocalin signature. 862908009766 Protein of unknown function (DUF523); Region: DUF523; pfam04463 862908009767 Uncharacterized conserved protein [Function unknown]; Region: COG3272 862908009768 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 862908009769 HMMPfam hit to PF04463, Protein of unknown function DUF523, score 7.6e-22 862908009770 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908009771 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 862908009772 DNA photolyase; Region: DNA_photolyase; pfam00875 862908009773 HMMPfam hit to PF00875, DNA photolyase, N-terminal, score 1.8e-33 862908009774 HMMPfam hit to PF03441, DNA photolyase, FAD-binding, score 5.9e-91 862908009775 PS00394 DNA photolyases class 1 signature 1. 862908009776 PS00691 DNA photolyases class 1 signature 2. 862908009777 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009778 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 862908009779 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 862908009780 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 862908009781 active site 862908009782 catalytic residues [active] 862908009783 Signal peptide predicted for BMS2622 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.977 between residues 17 and 18 862908009784 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.7e-05 862908009785 PS00138 Serine proteases, subtilase family, serine active site. 862908009786 HMMPfam hit to PF01814, Hemerythrin, score 3.4e-06 862908009787 2 probable transmembrane helices predicted for BMS2624 by TMHMM2.0 at aa 13-32 and 37-56 862908009788 primosome assembly protein PriA; Validated; Region: PRK05580 862908009789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862908009790 ATP binding site [chemical binding]; other site 862908009791 putative Mg++ binding site [ion binding]; other site 862908009792 helicase superfamily c-terminal domain; Region: HELICc; smart00490 862908009793 HMMPfam hit to PF00271, Helicase, C-terminal, score 0.0003 862908009794 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 2.9e-11 862908009795 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.6e-08 862908009796 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009797 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 862908009798 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862908009799 active site 862908009800 HIGH motif; other site 862908009801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862908009802 KMSKS motif; other site 862908009803 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862908009804 tRNA binding surface [nucleotide binding]; other site 862908009805 anticodon binding site; other site 862908009806 HMMPfam hit to PF01406, Cysteinyl-tRNA synthetase, class Ia, score 1.9e-151 862908009807 dihydroorotase; Validated; Region: PRK09060 862908009808 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908009809 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 862908009810 active site 862908009811 HMMPfam hit to PF01979, Amidohydrolase, score 6e-13 862908009812 PS00483 Dihydroorotase signature 2. 862908009813 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 862908009814 active site 862908009815 catalytic motif [active] 862908009816 Zn binding site [ion binding]; other site 862908009817 HMMPfam hit to PF00383, Cytidine/deoxycytidylate deaminase, zinc-binding region, score 1.8e-17 862908009818 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 862908009819 HMMPfam hit to PF02649, Protein of unknown function DUF198, score 7.5e-08 862908009820 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908009821 putative catalytic site [active] 862908009822 putative phosphate binding site [ion binding]; other site 862908009823 putative metal binding site [ion binding]; other site 862908009824 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.2e-06 862908009825 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862908009826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009827 active site 862908009828 phosphorylation site [posttranslational modification] 862908009829 intermolecular recognition site; other site 862908009830 dimerization interface [polypeptide binding]; other site 862908009831 CheB methylesterase; Region: CheB_methylest; pfam01339 862908009832 HMMPfam hit to PF01339, CheB methylesterase, score 4.8e-84 862908009833 HMMPfam hit to PF00072, Response regulator receiver, score 3.1e-23 862908009834 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862908009835 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 862908009836 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 862908009837 Response regulator receiver domain; Region: Response_reg; pfam00072 862908009838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908009839 active site 862908009840 phosphorylation site [posttranslational modification] 862908009841 intermolecular recognition site; other site 862908009842 dimerization interface [polypeptide binding]; other site 862908009843 HMMPfam hit to PF00072, Response regulator receiver, score 4.2e-23 862908009844 HMMPfam hit to PF01739, MCP methyltransferase, CheR-type, score 2.8e-40 862908009845 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862908009846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908009847 dimer interface [polypeptide binding]; other site 862908009848 putative CheW interface [polypeptide binding]; other site 862908009849 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 6.4e-37 862908009850 2 probable transmembrane helices predicted for BMS2634 by TMHMM2.0 at aa 15-37 and 340-362 862908009851 Signal peptide predicted for BMS2634 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.413 between residues 42 and 43 862908009852 Cache domain; Region: Cache_2; cl07034 862908009853 Signal peptide predicted for BMS2635 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 21 and 22 862908009854 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 862908009855 putative CheA interaction surface; other site 862908009856 HMMPfam hit to PF01584, CheW-like protein, score 5e-31 862908009857 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 862908009858 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862908009859 putative binding surface; other site 862908009860 active site 862908009861 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 862908009862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908009863 ATP binding site [chemical binding]; other site 862908009864 Mg2+ binding site [ion binding]; other site 862908009865 G-X-G motif; other site 862908009866 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 862908009867 HMMPfam hit to PF01584, CheW-like protein, score 1.1e-16 862908009868 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.6e-33 862908009869 HMMPfam hit to PF02895, Signal transducing histidine kinase, homodimeric, score 1.6e-08 862908009870 HMMPfam hit to PF01627, Hpt, score 7.7e-16 862908009871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862908009872 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 862908009873 dimer interface [polypeptide binding]; other site 862908009874 active site 862908009875 metal binding site [ion binding]; metal-binding site 862908009876 glutathione binding site [chemical binding]; other site 862908009877 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 1.3e-19 862908009878 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862908009879 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862908009880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908009881 Walker A motif; other site 862908009882 ATP binding site [chemical binding]; other site 862908009883 Walker B motif; other site 862908009884 arginine finger; other site 862908009885 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 862908009886 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 2.7e-136 862908009887 PS01046 ATP-dependent serine proteases, lon family, serine active site. 862908009888 HMMPfam hit to PF00004, AAA ATPase, central region, score 1.4e-51 862908009889 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009890 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009891 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 3.3e-41 862908009892 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 862908009893 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 862908009894 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 862908009895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908009896 Walker A motif; other site 862908009897 ATP binding site [chemical binding]; other site 862908009898 Walker B motif; other site 862908009899 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 862908009900 HMMPfam hit to PF00004, AAA ATPase, central region, score 4.3e-29 862908009901 HMMPfam hit to PF07724, , score 8.6e-76 862908009902 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009903 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 8.5e-23 862908009904 Clp protease; Region: CLP_protease; pfam00574 862908009905 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 862908009906 oligomer interface [polypeptide binding]; other site 862908009907 active site residues [active] 862908009908 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 1e-111 862908009909 PS00382 Endopeptidase Clp histidine active site. 862908009910 PS00381 Endopeptidase Clp serine active site. 862908009911 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 862908009912 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 862908009913 dimer interface [polypeptide binding]; other site 862908009914 decamer (pentamer of dimers) interface [polypeptide binding]; other site 862908009915 catalytic triad [active] 862908009916 peroxidatic and resolving cysteines [active] 862908009917 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 1.4e-74 862908009918 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862908009919 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862908009920 5 probable transmembrane helices predicted for BMS2643 by TMHMM2.0 at aa 13-32, 52-74, 109-131, 141-160 and 173-190 862908009921 HMMPfam hit to PF00597, DedA, score 5.3e-08 862908009922 PilZ domain; Region: PilZ; pfam07238 862908009923 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 862908009924 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 862908009925 putative active site [active] 862908009926 PhoH-like protein; Region: PhoH; pfam02562 862908009927 HMMPfam hit to PF02562, PhoH-like protein, score 4e-35 862908009928 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009929 Signal peptide predicted for BMS2647 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 18 and 19 862908009930 Signal peptide predicted for BMS2648 by SignalP 2.0 HMM (Signal peptide probability 0.891) with cleavage site probability 0.339 between residues 26 and 27 862908009931 aspartate aminotransferase; Provisional; Region: PRK05764 862908009932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862908009933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908009934 homodimer interface [polypeptide binding]; other site 862908009935 catalytic residue [active] 862908009936 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 3e-22 862908009937 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 862908009938 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 862908009939 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 862908009940 active site 862908009941 (T/H)XGH motif; other site 862908009942 HMMPfam hit to PF01467, Cytidylyltransferase, score 6.2e-30 862908009943 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 862908009944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908009945 HMMPfam hit to PF03602, Conserved hypothetical protein 95, score 4.7e-17 862908009946 PS00092 N-6 Adenine-specific DNA methylases signature. 862908009947 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 862908009948 Protein of unknown function, DUF399; Region: DUF399; cl01139 862908009949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908009950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908009951 ATP binding site [chemical binding]; other site 862908009952 Mg2+ binding site [ion binding]; other site 862908009953 G-X-G motif; other site 862908009954 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.2e-10 862908009955 1 probable transmembrane helix predicted for BMS2656 by TMHMM2.0 at aa 169-191 862908009956 Signal peptide predicted for BMS2656 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.937 between residues 31 and 32 862908009957 Gram-negative bacterial tonB protein; Region: TonB; cl10048 862908009958 1 probable transmembrane helix predicted for BMS2657 by TMHMM2.0 at aa 12-34 862908009959 Signal peptide predicted for BMS2661 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.383 between residues 20 and 21 862908009960 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009961 PS00018 EF-hand calcium-binding domain. 862908009962 glutathione synthetase; Provisional; Region: PRK05246 862908009963 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 862908009964 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908009965 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 862908009966 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908009967 Signal peptide predicted for BMS2663 by SignalP 2.0 HMM (Signal peptide probability 0.873) with cleavage site probability 0.485 between residues 20 and 21 862908009968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908009969 Signal peptide predicted for BMS2664 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 862908009970 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 862908009971 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862908009972 HMMPfam hit to PF04055, Radical SAM, score 1.4e-25 862908009973 PS01278 Uncharacterized protein family UPF0004 signature. 862908009974 HMMPfam hit to PF00919, Protein of unknown function UPF0004, score 8.4e-34 862908009975 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 862908009976 Clp amino terminal domain; Region: Clp_N; pfam02861 862908009977 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862908009978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908009979 Walker A motif; other site 862908009980 ATP binding site [chemical binding]; other site 862908009981 Walker B motif; other site 862908009982 arginine finger; other site 862908009983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908009984 Walker A motif; other site 862908009985 ATP binding site [chemical binding]; other site 862908009986 Walker B motif; other site 862908009987 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 862908009988 HMMPfam hit to PF00004, AAA ATPase, central region, score 5.6e-06 862908009989 HMMPfam hit to PF07724, , score 1.1e-89 862908009990 PS00871 Chaperonins clpA/B signature 2. 862908009991 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009992 HMMPfam hit to PF00004, AAA ATPase, central region, score 4e-11 862908009993 PS00870 Chaperonins clpA/B signature 1. 862908009994 PS00017 ATP/GTP-binding site motif A (P-loop). 862908009995 HMMPfam hit to PF02861, Clp, N terminal, score 1.2e-08 862908009996 Uncharacterized conserved protein [Function unknown]; Region: COG2127 862908009997 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein ClpS, score 3e-36 862908009998 Tellurite resistance protein TerB; Region: TerB; pfam05099 862908009999 HMMPfam hit to PF07049, Protein of unknown function DUF1332, score 3.9e-05 862908010000 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 862908010001 active site 862908010002 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908010003 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908010004 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 862908010005 30S subunit binding site; other site 862908010006 HMMPfam hit to PF02482, Sigma 54 modulation protein/ribosomal protein S30EA, score 9.6e-11 862908010007 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 862908010008 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 862908010009 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 862908010010 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 862908010011 HMMPfam hit to PF04552, Sigma-54, DNA-binding, score 1.7e-98 862908010012 PS00718 Sigma-54 factors family signature 2. 862908010013 PS00717 Sigma-54 factors family signature 1. 862908010014 HMMPfam hit to PF04963, Sigma-54 factor, core-binding region, score 2.9e-45 862908010015 HMMPfam hit to PF00309, Sigma-54 factor, score 4e-14 862908010016 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 862908010017 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 862908010018 Walker A/P-loop; other site 862908010019 ATP binding site [chemical binding]; other site 862908010020 Q-loop/lid; other site 862908010021 ABC transporter signature motif; other site 862908010022 Walker B; other site 862908010023 D-loop; other site 862908010024 H-loop/switch region; other site 862908010025 HMMPfam hit to PF00005, ABC transporter, score 2.1e-61 862908010026 PS00211 ABC transporters family signature. 862908010027 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010028 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 862908010029 1 probable transmembrane helix predicted for BMS2676 by TMHMM2.0 at aa 9-28 862908010030 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 862908010031 MutS domain I; Region: MutS_I; pfam01624 862908010032 MutS domain II; Region: MutS_II; pfam05188 862908010033 MutS domain III; Region: MutS_III; pfam05192 862908010034 MutS domain V; Region: MutS_V; pfam00488 862908010035 Walker A/P-loop; other site 862908010036 ATP binding site [chemical binding]; other site 862908010037 Q-loop/lid; other site 862908010038 ABC transporter signature motif; other site 862908010039 Walker B; other site 862908010040 D-loop; other site 862908010041 H-loop/switch region; other site 862908010042 HMMPfam hit to PF01624, DNA mismatch repair protein MutS, N-terminal, score 4.6e-58 862908010043 HMMPfam hit to PF05192, MutS III, score 3.4e-41 862908010044 HMMPfam hit to PF05190, MutS IV, score 1.4e-30 862908010045 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 2.9e-116 862908010046 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010047 PS00486 DNA mismatch repair proteins mutS family signature. 862908010048 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 862908010049 Signal peptide predicted for BMS2678 by SignalP 2.0 HMM (Signal peptide probability 0.812) with cleavage site probability 0.797 between residues 17 and 18 862908010050 RDD family; Region: RDD; pfam06271 862908010051 HMMPfam hit to PF06271, RDD, score 2.5e-08 862908010052 3 probable transmembrane helices predicted for BMS2679 by TMHMM2.0 at aa 28-50, 70-92 and 123-145 862908010053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 862908010054 substrate binding pocket [chemical binding]; other site 862908010055 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862908010056 membrane-bound complex binding site; other site 862908010057 hinge residues; other site 862908010058 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 862908010059 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 862908010060 dimer interface [polypeptide binding]; other site 862908010061 anticodon binding site; other site 862908010062 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862908010063 motif 1; other site 862908010064 dimer interface [polypeptide binding]; other site 862908010065 active site 862908010066 motif 2; other site 862908010067 GAD domain; Region: GAD; pfam02938 862908010068 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862908010069 active site 862908010070 motif 3; other site 862908010071 HMMPfam hit to PF00152, tRNA synthetase, class II (D, K and N), score 6e-12 862908010072 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908010073 HMMPfam hit to PF02938, GAD, score 4.3e-15 862908010074 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908010075 HMMPfam hit to PF01336, OB-fold nucleic acid binding, score 3.2e-18 862908010076 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 862908010077 HMMPfam hit to PF02643, Protein of unknown function DUF192, score 2.3e-18 862908010078 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 862908010079 Septum formation initiator; Region: DivIC; pfam04977 862908010080 1 probable transmembrane helix predicted for BMS2684 by TMHMM2.0 at aa 199-221 862908010081 YGGT family; Region: YGGT; pfam02325 862908010082 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 0.00033 862908010083 2 probable transmembrane helices predicted for BMS2686 by TMHMM2.0 at aa 7-24 and 55-74 862908010084 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 862908010085 HMMPfam hit to PF03631, Ribonuclease BN, score 2.9e-06 862908010086 6 probable transmembrane helices predicted for BMS2687 by TMHMM2.0 at aa 30-52, 96-118, 135-157, 193-215, 228-250 and 265-287 862908010087 PS00211 ABC transporters family signature. 862908010088 DNA polymerase II; Reviewed; Region: PRK05762 862908010089 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862908010090 active site 862908010091 catalytic site [active] 862908010092 substrate binding site [chemical binding]; other site 862908010093 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 862908010094 active site 862908010095 metal-binding site 862908010096 HMMPfam hit to PF00136, DNA polymerase B region, score 3.3e-55 862908010097 PS00116 DNA polymerase family B signature. 862908010098 HMMPfam hit to PF03104, DNA polymerase B, exonuclease, score 1.4e-21 862908010099 Peptidase M15; Region: Peptidase_M15_3; cl01194 862908010100 Signal peptide predicted for BMS2690 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.669 between residues 19 and 20 862908010101 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 862908010102 Chorismate mutase type II; Region: CM_2; smart00830 862908010103 HMMPfam hit to PF00793, DAHP synthetase I/KDSA superfamily, score 5.6e-30 862908010104 HMMPfam hit to PF01817, Chorismate mutase, score 2.8e-10 862908010105 aspartate aminotransferase; Provisional; Region: PRK05764 862908010106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862908010107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908010108 homodimer interface [polypeptide binding]; other site 862908010109 catalytic residue [active] 862908010110 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.1e-52 862908010111 arogenate dehydrogenase; Region: PLN02256 862908010112 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 862908010113 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 9.4e-11 862908010114 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 862908010115 Prephenate dehydratase; Region: PDT; pfam00800 862908010116 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 862908010117 putative L-Phe binding site [chemical binding]; other site 862908010118 HMMPfam hit to PF00800, Prephenate dehydratase, score 2.2e-21 862908010119 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.00063 862908010120 PS00858 Prephenate dehydratase signature 2. 862908010121 5 probable transmembrane helices predicted for BMS2695 by TMHMM2.0 at aa 5-23, 28-50, 62-81, 131-148 and 155-177 862908010122 WYL domain; Region: WYL; cl14852 862908010123 1 probable transmembrane helix predicted for BMS2697 by TMHMM2.0 at aa 7-29 862908010124 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908010125 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908010126 active site 862908010127 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.7e-17 862908010128 PS01129 Rlu family of pseudouridine synthase signature. 862908010129 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 862908010130 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862908010131 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862908010132 ligand binding site [chemical binding]; other site 862908010133 1 probable transmembrane helix predicted for BMS2699 by TMHMM2.0 at aa 32-54 862908010134 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862908010135 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 862908010136 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 3.6e-06 862908010137 PS01307 Flagellar motor protein motA family signature. 862908010138 4 probable transmembrane helices predicted for BMS2700 by TMHMM2.0 at aa 5-24, 28-50, 144-166 and 176-198 862908010139 Signal peptide predicted for BMS2700 by SignalP 2.0 HMM (Signal peptide probability 0.779) with cleavage site probability 0.372 between residues 16 and 17 862908010140 PS00190 Cytochrome c family heme-binding site signature. 862908010141 Signal peptide predicted for BMS2701 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.965 between residues 17 and 18 862908010142 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862908010143 Signal peptide predicted for BMS2702 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.854 between residues 17 and 18 862908010144 Signal peptide predicted for BMS2704 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.738 between residues 22 and 23 862908010145 Signal peptide predicted for BMS2706 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.915 between residues 27 and 28 862908010146 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010147 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 862908010148 HMMPfam hit to PF00425, Anthranilate synthase component I and chorismate binding protein, score 1.1e-15 862908010149 replicative DNA helicase; Region: DnaB; TIGR00665 862908010150 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862908010151 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862908010152 Walker A motif; other site 862908010153 ATP binding site [chemical binding]; other site 862908010154 Walker B motif; other site 862908010155 DNA binding loops [nucleotide binding] 862908010156 HMMPfam hit to PF03796, DnaB-like helicase, C-terminal, score 7.6e-105 862908010157 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010158 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010159 HMMPfam hit to PF00772, DnaB-like helicase, N-terminal, score 1.9e-28 862908010160 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 862908010161 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 862908010162 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 862908010163 HMMPfam hit to PF03948, Ribosomal protein L9, score 1.8e-10 862908010164 HMMPfam hit to PF01281, Ribosomal protein L9, score 6.3e-18 862908010165 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 862908010166 8 probable transmembrane helices predicted for BMS2712 by TMHMM2.0 at aa 34-56, 71-90, 97-116, 131-148, 196-218, 248-270, 277-299 and 314-336 862908010167 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 862908010168 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 862908010169 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.5e-05 862908010170 HMMPfam hit to PF01250, Ribosomal protein S6, score 5e-07 862908010171 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 862908010172 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 0.0021 862908010173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862908010174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 862908010175 DNA binding site [nucleotide binding] 862908010176 ribonuclease G; Provisional; Region: PRK11712 862908010177 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 862908010178 homodimer interface [polypeptide binding]; other site 862908010179 oligonucleotide binding site [chemical binding]; other site 862908010180 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 862908010181 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 862908010182 Nucleoside recognition; Region: Gate; pfam07670 862908010183 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 862908010184 HMMPfam hit to PF07662, , score 4.9e-110 862908010185 9 probable transmembrane helices predicted for BMS2717 by TMHMM2.0 at aa 4-21, 28-47, 90-112, 167-189, 193-215, 259-281, 296-318, 351-373 and 388-405 862908010186 HMMPfam hit to PF07670, , score 2.9e-16 862908010187 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter, score 2.5e-27 862908010188 Signal peptide predicted for BMS2717 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.779 between residues 21 and 22 862908010189 3 probable transmembrane helices predicted for BMS2718 by TMHMM2.0 at aa 9-26, 41-60 and 72-89 862908010190 Signal peptide predicted for BMS2718 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27 862908010191 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 862908010192 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862908010193 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862908010194 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 862908010195 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 3.1e-18 862908010196 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010197 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 3.2e-45 862908010198 purine nucleoside phosphorylase; Provisional; Region: PRK08202 862908010199 HMMPfam hit to PF00896, Purine phosphorylase, family 2, score 1.3e-92 862908010200 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862908010201 active site 862908010202 catalytic site [active] 862908010203 substrate binding site [chemical binding]; other site 862908010204 HMMPfam hit to PF00929, Exonuclease, score 2.3e-43 862908010205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908010206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908010207 phosphorylation site [posttranslational modification] 862908010208 dimer interface [polypeptide binding]; other site 862908010209 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.8e-11 862908010210 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 862908010211 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 862908010212 generic binding surface II; other site 862908010213 generic binding surface I; other site 862908010214 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 3e-31 862908010215 HMMPfam hit to PF01336, OB-fold nucleic acid binding, score 9.6e-10 862908010216 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862908010217 C-terminal peptidase (prc); Region: prc; TIGR00225 862908010218 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862908010219 protein binding site [polypeptide binding]; other site 862908010220 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862908010221 Catalytic dyad [active] 862908010222 HMMPfam hit to PF03572, Peptidase S41, score 2.3e-67 862908010223 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 8.8e-12 862908010224 Signal peptide predicted for BMS2724 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.648 between residues 35 and 36 862908010225 1 probable transmembrane helix predicted for BMS2724 by TMHMM2.0 at aa 7-29 862908010226 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862908010227 Peptidase family M23; Region: Peptidase_M23; pfam01551 862908010228 HMMPfam hit to PF01551, Peptidase M23B, score 7.8e-13 862908010229 Signal peptide predicted for BMS2725 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 862908010230 3 probable transmembrane helices predicted for BMS2726 by TMHMM2.0 at aa 148-170, 190-212 and 217-234 862908010231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908010232 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862908010233 Walker A/P-loop; other site 862908010234 ATP binding site [chemical binding]; other site 862908010235 Q-loop/lid; other site 862908010236 ABC transporter signature motif; other site 862908010237 Walker B; other site 862908010238 D-loop; other site 862908010239 H-loop/switch region; other site 862908010240 HMMPfam hit to PF00005, ABC transporter, score 2.1e-41 862908010241 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010242 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 862908010243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908010244 Zn2+ binding site [ion binding]; other site 862908010245 Mg2+ binding site [ion binding]; other site 862908010246 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 862908010247 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862908010248 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 862908010249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908010250 Walker A motif; other site 862908010251 ATP binding site [chemical binding]; other site 862908010252 Walker B motif; other site 862908010253 arginine finger; other site 862908010254 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908010255 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 8.2e-12 862908010256 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 1.2e-71 862908010257 HMMPfam hit to PF01590, GAF, score 6e-05 862908010258 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 862908010259 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862908010260 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862908010261 HMMPfam hit to PF07676, , score 1.9e-05 862908010262 HMMPfam hit to PF07676, , score 5.1e-05 862908010263 HMMPfam hit to PF07676, , score 0.036 862908010264 HMMPfam hit to PF07676, , score 1 862908010265 Signal peptide predicted for BMS2732 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.943 between residues 18 and 19 862908010266 Gram-negative bacterial tonB protein; Region: TonB; cl10048 862908010267 1 probable transmembrane helix predicted for BMS2733 by TMHMM2.0 at aa 13-32 862908010268 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 862908010269 TolR protein; Region: tolR; TIGR02801 862908010270 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 3.9e-18 862908010271 1 probable transmembrane helix predicted for BMS2734 by TMHMM2.0 at aa 20-42 862908010272 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862908010273 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 5.1e-37 862908010274 3 probable transmembrane helices predicted for BMS2735 by TMHMM2.0 at aa 15-37, 135-157 and 177-199 862908010275 8 probable transmembrane helices predicted for BMS2736 by TMHMM2.0 at aa 13-35, 59-81, 102-124, 134-155, 167-186, 190-208, 215-237 and 252-269 862908010276 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 862908010277 Signal peptide predicted for BMS2737 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.729 between residues 18 and 19 862908010278 fructose-bisphosphate aldolase; Region: PLN02858 862908010279 Signal peptide predicted for BMS2738 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.778 between residues 21 and 22 862908010280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908010281 TPR motif; other site 862908010282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862908010283 binding surface 862908010284 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908010285 HMMPfam hit to PF07719, , score 0.024; PF07719, Tetratricopeptide repeat 862908010286 HMMPfam hit to PF07719, , score 2; PF07719, Tetratricopeptide repeat 862908010287 1 probable transmembrane helix predicted for BMS2739 by TMHMM2.0 at aa 7-29 862908010288 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 862908010289 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 862908010290 tandem repeat interface [polypeptide binding]; other site 862908010291 oligomer interface [polypeptide binding]; other site 862908010292 active site residues [active] 862908010293 HMMPfam hit to PF01343, Peptidase S49, score 1.7e-39 862908010294 1 probable transmembrane helix predicted for BMS2740 by TMHMM2.0 at aa 55-77 862908010295 Signal peptide predicted for BMS2741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.527 between residues 19 and 20 862908010296 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 862908010297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908010298 FeS/SAM binding site; other site 862908010299 HMMPfam hit to PF04055, Radical SAM, score 1.6e-10 862908010300 PS00190 Cytochrome c family heme-binding site signature. 862908010301 Ycf27; Reviewed; Region: orf27; CHL00148 862908010302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908010303 active site 862908010304 phosphorylation site [posttranslational modification] 862908010305 intermolecular recognition site; other site 862908010306 dimerization interface [polypeptide binding]; other site 862908010307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862908010308 DNA binding site [nucleotide binding] 862908010309 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.8e-14 862908010310 HMMPfam hit to PF00072, Response regulator receiver, score 6e-26 862908010311 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908010312 putative catalytic site [active] 862908010313 putative metal binding site [ion binding]; other site 862908010314 putative phosphate binding site [ion binding]; other site 862908010315 1 probable transmembrane helix predicted for BMS2744 by TMHMM2.0 at aa 13-32 862908010316 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.4e-11 862908010317 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010318 HMMPfam hit to PF00072, Response regulator receiver, score 0.0011 862908010319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908010320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908010321 active site 862908010322 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 1.2e-39 862908010323 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 7.2e-49 862908010324 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 4.4e-64 862908010325 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010326 PS00073 Acyl-CoA dehydrogenases signature 2. 862908010327 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862908010328 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase (SpoU), score 1.7e-20 862908010329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908010330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908010331 active site 862908010332 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 7.9e-07 862908010333 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 3.7e-50 862908010334 PS00072 Acyl-CoA dehydrogenases signature 1. 862908010335 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 1.3e-75 862908010336 PS00073 Acyl-CoA dehydrogenases signature 2. 862908010337 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 862908010338 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 862908010339 active site 862908010340 dimer interface [polypeptide binding]; other site 862908010341 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 862908010342 dimer interface [polypeptide binding]; other site 862908010343 active site 862908010344 HMMPfam hit to PF00342, Phosphoglucose isomerase (PGI), score 2.1e-28 862908010345 PS00765 Phosphoglucose isomerase signature 1. 862908010346 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908010347 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908010348 phosphopeptide binding site; other site 862908010349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862908010350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862908010351 metal binding site [ion binding]; metal-binding site 862908010352 active site 862908010353 I-site; other site 862908010354 HMMPfam hit to PF00498, Forkhead-associated, score 2.9e-13 862908010355 HMMPfam hit to PF00990, GGDEF, score 1.9e-50 862908010356 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 862908010357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908010358 ATP binding site [chemical binding]; other site 862908010359 Mg2+ binding site [ion binding]; other site 862908010360 G-X-G motif; other site 862908010361 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 862908010362 ATP binding site [chemical binding]; other site 862908010363 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 862908010364 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.0042 862908010365 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 862908010366 HMMPfam hit to PF01119, DNA mismatch repair protein, score 8.4e-06 862908010367 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 862908010368 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 862908010369 Signal peptide predicted for BMS2755 by SignalP 2.0 HMM (Signal peptide probability 0.890) with cleavage site probability 0.548 between residues 29 and 30 862908010370 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010371 HMMPfam hit to PF01715, tRNA isopentenyltransferase, score 7e-50 862908010372 PEP synthetase regulatory protein; Provisional; Region: PRK05339 862908010373 HMMPfam hit to PF03618, Protein of unknown function DUF299, score 2.1e-90 862908010374 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010375 PRC-barrel domain; Region: PRC; pfam05239 862908010376 MgtE intracellular N domain; Region: MgtE_N; smart00924 862908010377 FOG: CBS domain [General function prediction only]; Region: COG0517 862908010378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 862908010379 HMMPfam hit to PF05239, PRC-barrel, score 4.7e-05 862908010380 HMMPfam hit to PF03448, MgtE intracellular region, score 4.4e-21 862908010381 HMMPfam hit to PF00571, CBS, score 0.0019 862908010382 HMMPfam hit to PF00571, CBS, score 9.3e-09 862908010383 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 862908010384 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 862908010385 11 probable transmembrane helices predicted for BMS2758 by TMHMM2.0 at aa 12-31, 46-68, 97-119, 124-143, 155-177, 197-216, 237-259, 286-308, 329-351, 356-378 and 391-413 862908010386 HMMPfam hit to PF01566, Natural resistance-associated macrophage protein, score 9.2e-08 862908010387 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862908010388 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862908010389 active site 862908010390 ATP binding site [chemical binding]; other site 862908010391 substrate binding site [chemical binding]; other site 862908010392 activation loop (A-loop); other site 862908010393 HMMPfam hit to PF00069, Protein kinase, score 2.5e-33 862908010394 PS00109 Tyrosine protein kinases specific active-site signature. 862908010395 Signal peptide predicted for BMS2760 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.397 between residues 19 and 20 862908010396 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862908010397 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862908010398 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 862908010399 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 862908010400 PilZ domain; Region: PilZ; pfam07238 862908010401 Signal peptide predicted for BMS2763 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.561 between residues 23 and 24 862908010402 PS00063 Aldo/keto reductase family putative active site signature. 862908010403 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908010404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908010405 ligand binding site [chemical binding]; other site 862908010406 flexible hinge region; other site 862908010407 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 2.9e-16 862908010408 putative acyltransferase; Provisional; Region: PRK05790 862908010409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862908010410 dimer interface [polypeptide binding]; other site 862908010411 active site 862908010412 HMMPfam hit to PF02803, Thiolase, score 1.3e-50 862908010413 PS00099 Thiolases active site. 862908010414 PS00737 Thiolases signature 2. 862908010415 HMMPfam hit to PF00108, Thiolase, score 2.4e-128 862908010416 PS00098 Thiolases acyl-enzyme intermediate signature. 862908010417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908010418 Coenzyme A binding pocket [chemical binding]; other site 862908010419 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.8e-18 862908010420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908010421 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 862908010422 FAD binding site [chemical binding]; other site 862908010423 homotetramer interface [polypeptide binding]; other site 862908010424 substrate binding pocket [chemical binding]; other site 862908010425 catalytic base [active] 862908010426 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 1.1e-76 862908010427 PS00073 Acyl-CoA dehydrogenases signature 2. 862908010428 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 3.3e-41 862908010429 PS00072 Acyl-CoA dehydrogenases signature 1. 862908010430 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 2e-47 862908010431 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 862908010432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862908010433 substrate binding site [chemical binding]; other site 862908010434 oxyanion hole (OAH) forming residues; other site 862908010435 trimer interface [polypeptide binding]; other site 862908010436 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase, score 9.5e-65 862908010437 PS00166 Enoyl-CoA hydratase/isomerase signature. 862908010438 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010439 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 862908010440 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862908010441 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862908010442 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 4e-50 862908010443 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 9e-84 862908010444 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010445 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 862908010446 HMMPfam hit to PF01649, Ribosomal protein S20, score 4.7e-23 862908010447 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 862908010448 Lipopolysaccharide-assembly; Region: LptE; cl01125 862908010449 Signal peptide predicted for BMS2775 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.681 between residues 21 and 22 862908010450 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010451 Protein of unknown function (DUF721); Region: DUF721; pfam05258 862908010452 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908010453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862908010454 PS00092 N-6 Adenine-specific DNA methylases signature. 862908010455 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 862908010456 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 3.5e-09 862908010457 1 probable transmembrane helix predicted for BMS2780 by TMHMM2.0 at aa 302-324 862908010458 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 862908010459 mce related protein; Region: MCE; pfam02470 862908010460 HMMPfam hit to PF02470, Mce4/Rv3499c/MTV023.06c protein, score 1.7e-09 862908010461 Signal peptide predicted for BMS2781 by SignalP 2.0 HMM (Signal peptide probability 0.708) with cleavage site probability 0.216 between residues 20 and 21 862908010462 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 862908010463 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 862908010464 Walker A/P-loop; other site 862908010465 ATP binding site [chemical binding]; other site 862908010466 Q-loop/lid; other site 862908010467 ABC transporter signature motif; other site 862908010468 Walker B; other site 862908010469 D-loop; other site 862908010470 H-loop/switch region; other site 862908010471 HMMPfam hit to PF00005, ABC transporter, score 7.8e-49 862908010472 PS00211 ABC transporters family signature. 862908010473 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010474 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 862908010475 Permease; Region: Permease; pfam02405 862908010476 7 probable transmembrane helices predicted for BMS2783 by TMHMM2.0 at aa 12-34, 49-67, 87-109, 119-141, 190-212, 232-254 and 267-289 862908010477 HMMPfam hit to PF02405, Protein of unknown function DUF140, score 6.6e-82 862908010478 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908010479 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908010480 phosphopeptide binding site; other site 862908010481 HMMPfam hit to PF00498, Forkhead-associated, score 2.5e-10 862908010482 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 862908010483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 862908010484 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862908010485 catalytic residue [active] 862908010486 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 6.9e-12 862908010487 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 9.9e-31 862908010488 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 862908010489 ADP binding site [chemical binding]; other site 862908010490 magnesium binding site [ion binding]; other site 862908010491 putative shikimate binding site; other site 862908010492 HMMPfam hit to PF01202, Shikimate kinase, score 2.8e-20 862908010493 PS01128 Shikimate kinase signature. 862908010494 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010495 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 862908010496 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 862908010497 HMMPfam hit to PF01783, Ribosomal L32p protein, score 2.1e-07 862908010498 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 862908010499 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862908010500 dimer interface [polypeptide binding]; other site 862908010501 active site 862908010502 CoA binding pocket [chemical binding]; other site 862908010503 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 862908010504 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862908010505 HMMPfam hit to PF00698, Acyl transferase region, score 5.5e-11 862908010506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908010507 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 862908010508 NAD(P) binding site [chemical binding]; other site 862908010509 active site 862908010510 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.3e-84 862908010511 PS00061 Short-chain dehydrogenases/reductases family signature. 862908010512 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 862908010513 acyl carrier protein; Provisional; Region: acpP; PRK00982 862908010514 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 3e-15 862908010515 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 862908010516 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 862908010517 dimer interface [polypeptide binding]; other site 862908010518 active site 862908010519 HMMPfam hit to PF00109, Beta-ketoacyl synthase, score 8.4e-65 862908010520 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010521 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010522 PS00606 Beta-ketoacyl synthases active site. 862908010523 HMMPfam hit to PF02801, Beta-ketoacyl synthase, score 2.4e-75 862908010524 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862908010525 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862908010526 dimer interface [polypeptide binding]; other site 862908010527 active site 862908010528 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862908010529 folate binding site [chemical binding]; other site 862908010530 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 6.4e-252 862908010531 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 862908010532 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 862908010533 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 862908010534 active site 862908010535 FMN binding site [chemical binding]; other site 862908010536 substrate binding site [chemical binding]; other site 862908010537 3Fe-4S cluster binding site [ion binding]; other site 862908010538 HMMPfam hit to PF01645, Ferredoxin-dependent glutamate synthase, score 4.3e-82 862908010539 1 probable transmembrane helix predicted for BMS2796 by TMHMM2.0 at aa 5-27 862908010540 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 862908010541 Signal peptide predicted for BMS2797 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 17 and 18 862908010542 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 862908010543 ATP cone domain; Region: ATP-cone; pfam03477 862908010544 HMMPfam hit to PF03477, ATP-cone, score 3.4e-24 862908010545 transcription antitermination factor NusB; Region: nusB; TIGR01951 862908010546 putative RNA binding site [nucleotide binding]; other site 862908010547 HMMPfam hit to PF01029, Antitermination protein NusB, score 1.3e-17 862908010548 Signal peptide predicted for BMS2801 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.987 between residues 18 and 19 862908010549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908010550 S-adenosylmethionine binding site [chemical binding]; other site 862908010551 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908010552 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 862908010553 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862908010554 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862908010555 HMMPfam hit to PF01272, Prokaryotic transcription elongation factor GreA/GreB, score 8.3e-26 862908010556 HMMPfam hit to PF03449, Prokaryotic transcription elongation factor GreA/GreB, score 3e-24 862908010557 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862908010558 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862908010559 active site 862908010560 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein phosphatase, score 1.7e-40 862908010561 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862908010562 active site 862908010563 catalytic residues [active] 862908010564 metal binding site [ion binding]; metal-binding site 862908010565 HMMPfam hit to PF01327, Formylmethionine deformylase, score 5e-39 862908010566 1 probable transmembrane helix predicted for BMS2807 by TMHMM2.0 at aa 7-29 862908010567 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 862908010568 putative active site [active] 862908010569 catalytic site [active] 862908010570 PLD-like domain; Region: PLDc_2; pfam13091 862908010571 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908010572 putative active site [active] 862908010573 catalytic site [active] 862908010574 Signal peptide predicted for BMS2808 by SignalP 2.0 HMM (Signal peptide probability 0.946) with cleavage site probability 0.934 between residues 16 and 17 862908010575 Signal peptide predicted for BMS2809 by SignalP 2.0 HMM (Signal peptide probability 0.829) with cleavage site probability 0.265 between residues 28 and 29 862908010576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010577 short chain dehydrogenase; Provisional; Region: PRK07024 862908010578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908010579 NAD(P) binding site [chemical binding]; other site 862908010580 active site 862908010581 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.4e-38 862908010582 PS00061 Short-chain dehydrogenases/reductases family signature. 862908010583 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862908010584 Signal peptide predicted for BMS2811 by SignalP 2.0 HMM (Signal peptide probability 0.951) with cleavage site probability 0.625 between residues 60 and 61 862908010585 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 1.8e-23 862908010586 1 probable transmembrane helix predicted for BMS2813 by TMHMM2.0 at aa 387-409 862908010587 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 862908010588 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 9.4e-09 862908010589 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 862908010590 HMMPfam hit to PF02639, Protein of unknown function DUF188, score 6.5e-59 862908010591 10 probable transmembrane helices predicted for BMS2818 by TMHMM2.0 at aa 3-17, 27-49, 56-77, 97-119, 159-181, 196-218, 238-260, 275-294, 315-337 and 365-387 862908010592 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 862908010593 HMMPfam hit to PF02525, NAD(P)H dehydrogenase (quinone), score 6.1e-32 862908010594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862908010595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862908010596 WHG domain; Region: WHG; pfam13305 862908010597 HMMPfam hit to PF00440, Bacterial regulatory protein, TetR, score 1.3e-09 862908010598 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 862908010599 putative dimer interface [polypeptide binding]; other site 862908010600 catalytic triad [active] 862908010601 HMMPfam hit to PF02016, Peptidase U61, LD-carboxypeptidase A, score 2e-30 862908010602 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 862908010603 Signal peptide predicted for BMS2822 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 34 and 35 862908010604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908010605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908010606 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 862908010607 putative effector binding pocket; other site 862908010608 putative dimerization interface [polypeptide binding]; other site 862908010609 HMMPfam hit to PF03466, LysR, substrate-binding, score 5e-29 862908010610 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.3e-16 862908010611 PS00044 Bacterial regulatory proteins, lysR family signature. 862908010612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862908010613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908010614 NAD(P) binding site [chemical binding]; other site 862908010615 active site 862908010616 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8.1e-48 862908010617 Signal peptide predicted for BMS2825 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 17 and 18 862908010618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862908010619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908010620 active site 862908010621 phosphorylation site [posttranslational modification] 862908010622 intermolecular recognition site; other site 862908010623 dimerization interface [polypeptide binding]; other site 862908010624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862908010625 DNA binding residues [nucleotide binding] 862908010626 dimerization interface [polypeptide binding]; other site 862908010627 HMMPfam hit to PF00072, Response regulator receiver, score 4.7e-22 862908010628 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3e-07 862908010629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908010630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862908010631 dimerization interface [polypeptide binding]; other site 862908010632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908010633 ATP binding site [chemical binding]; other site 862908010634 Mg2+ binding site [ion binding]; other site 862908010635 G-X-G motif; other site 862908010636 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.9e-15 862908010637 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0079 862908010638 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 6.7e-07 862908010639 2 probable transmembrane helices predicted for BMS2827 by TMHMM2.0 at aa 10-29 and 311-333 862908010640 Signal peptide predicted for BMS2827 by SignalP 2.0 HMM (Signal peptide probability 0.852) with cleavage site probability 0.393 between residues 31 and 32 862908010641 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 862908010642 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 862908010643 HMMPfam hit to PF03352, Methyladenine glycosylase, score 1.1e-87 862908010644 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 862908010645 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 862908010646 HMMPfam hit to PF00127, Blue (type 1) copper domain, score 3.1e-06 862908010647 Signal peptide predicted for BMS2831 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.992 between residues 20 and 21 862908010648 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 862908010649 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 862908010650 dimer interface [polypeptide binding]; other site 862908010651 active site 862908010652 heme binding site [chemical binding]; other site 862908010653 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 862908010654 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 2.6e-90 862908010655 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 9.4e-83 862908010656 PS00435 Peroxidases proximal heme-ligand signature. 862908010657 PS00436 Peroxidases active site signature. 862908010658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010659 Signal peptide predicted for BMS2832 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.568 between residues 16 and 17 862908010660 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 862908010661 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862908010662 active site 862908010663 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862908010664 active site 2 [active] 862908010665 active site 1 [active] 862908010666 HMMPfam hit to PF01643, Acyl-ACP thioesterase, score 1.1e-27 862908010667 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 862908010668 N-terminal domain interface [polypeptide binding]; other site 862908010669 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908010670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908010671 substrate binding pocket [chemical binding]; other site 862908010672 membrane-bound complex binding site; other site 862908010673 hinge residues; other site 862908010674 Signal peptide predicted for BMS2835 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.807 between residues 20 and 21 862908010675 Signal peptide predicted for BMS2836 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.800 between residues 17 and 18 862908010676 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862908010677 HMMPfam hit to PF00873, Acriflavin resistance protein, score 2.2e-181 862908010678 11 probable transmembrane helices predicted for BMS2837 by TMHMM2.0 at aa 10-32, 329-351, 356-373, 386-408, 428-450, 463-485, 525-547, 858-880, 895-917, 946-965 and 975-997 862908010679 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862908010680 Signal peptide predicted for BMS2838 by SignalP 2.0 HMM (Signal peptide probability 0.868) with cleavage site probability 0.593 between residues 15 and 16 862908010681 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 862908010682 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.9e-05 862908010683 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.6e-19 862908010684 Signal peptide predicted for BMS2839 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 23 and 24 862908010685 MarR family; Region: MarR_2; pfam12802 862908010686 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 5.2e-23 862908010687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862908010688 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862908010689 substrate binding pocket [chemical binding]; other site 862908010690 membrane-bound complex binding site; other site 862908010691 hinge residues; other site 862908010692 Signal peptide predicted for BMS2841 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.970 between residues 32 and 33 862908010693 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 862908010694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908010695 putative substrate translocation pore; other site 862908010696 12 probable transmembrane helices predicted for BMS2842 by TMHMM2.0 at aa 9-31, 46-63, 76-93, 99-121, 133-155, 159-181, 213-235, 245-267, 274-296, 301-323, 336-358 and 363-385 862908010697 HMMPfam hit to PF07690, , score 9.7e-46 862908010698 Signal peptide predicted for BMS2842 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.420 between residues 32 and 33 862908010699 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862908010700 active site 2 [active] 862908010701 active site 1 [active] 862908010702 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 862908010703 active site 862908010704 Signal peptide predicted for BMS2845 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.953 between residues 23 and 24 862908010705 5 probable transmembrane helices predicted for BMS2845 by TMHMM2.0 at aa 2-20, 35-57, 78-100, 168-185 and 192-214 862908010706 HMMPfam hit to PF01569, Phosphoesterase, PA-phosphatase related, score 6.2e-14 862908010707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908010708 Response regulator receiver domain; Region: Response_reg; pfam00072 862908010709 active site 862908010710 phosphorylation site [posttranslational modification] 862908010711 intermolecular recognition site; other site 862908010712 dimerization interface [polypeptide binding]; other site 862908010713 HMMPfam hit to PF00072, Response regulator receiver, score 4.9e-17 862908010714 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862908010715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908010716 dimer interface [polypeptide binding]; other site 862908010717 phosphorylation site [posttranslational modification] 862908010718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908010719 ATP binding site [chemical binding]; other site 862908010720 Mg2+ binding site [ion binding]; other site 862908010721 G-X-G motif; other site 862908010722 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.1e-27 862908010723 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.4e-05 862908010724 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 862908010725 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 862908010726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862908010727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862908010728 dimerization interface [polypeptide binding]; other site 862908010729 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862908010730 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.00064 862908010731 HMMPfam hit to PF07228, Stage II sporulation E, score 4.2e-28 862908010732 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.2e-15 862908010733 2 probable transmembrane helices predicted for BMS2850 by TMHMM2.0 at aa 18-40 and 257-279 862908010734 Signal peptide predicted for BMS2850 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.427 between residues 42 and 43 862908010735 1 probable transmembrane helix predicted for BMS2851 by TMHMM2.0 at aa 9-27 862908010736 Signal peptide predicted for BMS2852 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.992 between residues 19 and 20 862908010737 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 862908010738 HMMPfam hit to PF01391, Collagen triple helix repeat, score 8.4e-15 862908010739 HMMPfam hit to PF01391, Collagen triple helix repeat, score 2.7e-12 862908010740 HMMPfam hit to PF01391, Collagen triple helix repeat, score 1.8e-11 862908010741 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862908010742 putative binding surface; other site 862908010743 active site 862908010744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908010745 phosphorylation site [posttranslational modification] 862908010746 intermolecular recognition site; other site 862908010747 HMMPfam hit to PF01627, Hpt, score 1.2e-12 862908010748 HMMPfam hit to PF00072, Response regulator receiver, score 1.2e-06 862908010749 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 862908010750 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 862908010751 XdhC Rossmann domain; Region: XdhC_C; pfam13478 862908010752 HMMPfam hit to PF02625, Protein of unknown function DUF182, score 1.6e-06 862908010753 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 862908010754 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862908010755 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862908010756 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding, score 3.8e-219 862908010757 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead, score 3.5e-24 862908010758 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 862908010759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862908010760 catalytic loop [active] 862908010761 iron binding site [ion binding]; other site 862908010762 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862908010763 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 862908010764 HMMPfam hit to PF03450, CO dehydrogenase flavoprotein, C-terminal, score 1.5e-14 862908010765 HMMPfam hit to PF00941, Molybdopterin dehydrogenase, FAD-binding, score 4.2e-25 862908010766 HMMPfam hit to PF01799, [2Fe-2S]-binding, score 3.8e-28 862908010767 HMMPfam hit to PF00111, Ferredoxin, score 0.0026 862908010768 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 862908010769 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908010770 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 862908010771 active site 862908010772 HMMPfam hit to PF00849, Pseudouridine synthase, score 8.6e-34 862908010773 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908010774 putative catalytic site [active] 862908010775 putative phosphate binding site [ion binding]; other site 862908010776 putative metal binding site [ion binding]; other site 862908010777 Signal peptide predicted for BMS2859 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.969 between residues 24 and 25 862908010778 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908010779 Signal peptide predicted for BMS2860 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.847 between residues 18 and 19 862908010780 Signal peptide predicted for BMS2861 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 20 and 21 862908010781 PS00141 Eukaryotic and viral aspartyl proteases active site. 862908010782 3 probable transmembrane helices predicted for BMS2862 by TMHMM2.0 at aa 21-43, 978-1000 and 1007-1029 862908010783 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 862908010784 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 862908010785 acyl-activating enzyme (AAE) consensus motif; other site 862908010786 putative AMP binding site [chemical binding]; other site 862908010787 putative active site [active] 862908010788 putative CoA binding site [chemical binding]; other site 862908010789 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1.5e-127 862908010790 PS00455 Putative AMP-binding domain signature. 862908010791 PS00211 ABC transporters family signature. 862908010792 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010793 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 862908010794 GIY-YIG motif/motif A; other site 862908010795 putative active site [active] 862908010796 putative metal binding site [ion binding]; other site 862908010797 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 2.8e-16 862908010798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908010799 dimer interface [polypeptide binding]; other site 862908010800 phosphorylation site [posttranslational modification] 862908010801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908010802 ATP binding site [chemical binding]; other site 862908010803 Mg2+ binding site [ion binding]; other site 862908010804 G-X-G motif; other site 862908010805 Response regulator receiver domain; Region: Response_reg; pfam00072 862908010806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908010807 active site 862908010808 phosphorylation site [posttranslational modification] 862908010809 intermolecular recognition site; other site 862908010810 dimerization interface [polypeptide binding]; other site 862908010811 HMMPfam hit to PF00072, Response regulator receiver, score 5.9e-22 862908010812 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.2e-40 862908010813 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.9e-24 862908010814 2 probable transmembrane helices predicted for BMS2866 by TMHMM2.0 at aa 10-28 and 182-204 862908010815 Signal peptide predicted for BMS2866 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.439 between residues 23 and 24 862908010816 Signal peptide predicted for BMS2867 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.857 between residues 24 and 25 862908010817 Signal peptide predicted for BMS2868 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.574 between residues 22 and 23 862908010818 Signal peptide predicted for BMS2869 by SignalP 2.0 HMM (Signal peptide probability 0.871) with cleavage site probability 0.497 between residues 18 and 19 862908010819 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 862908010820 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 862908010821 HMMPfam hit to PF01238, Mannose-6-phosphate isomerase, type I, score 1.7e-07 862908010822 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 862908010823 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 862908010824 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 4.8e-05 862908010825 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 862908010826 6 probable transmembrane helices predicted for BMS2872 by TMHMM2.0 at aa 36-58, 79-97, 101-123, 136-155, 160-182 and 189-206 862908010827 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 5e-07 862908010828 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 862908010829 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 862908010830 P-loop; other site 862908010831 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010832 DnaJ domain; Region: DnaJ; pfam00226 862908010833 HSP70 interaction site [polypeptide binding]; other site 862908010834 Helix-turn-helix domain; Region: HTH_25; pfam13413 862908010835 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 1.8e-06 862908010836 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908010837 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908010838 active site 862908010839 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.2e-57 862908010840 PS01129 Rlu family of pseudouridine synthase signature. 862908010841 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 862908010842 HMMPfam hit to PF02578, Protein of unknown function DUF152, score 1.1e-12 862908010843 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 862908010844 putative active site [active] 862908010845 redox center [active] 862908010846 Thioredoxin; Region: Thioredoxin_4; cl17273 862908010847 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862908010848 5 probable transmembrane helices predicted for BMS2877 by TMHMM2.0 at aa 21-43, 82-104, 116-138, 143-157 and 164-186 862908010849 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.4e-05 862908010850 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 862908010851 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 862908010852 active site 862908010853 HMMPfam hit to PF01026, TatD-related deoxyribonuclease, score 7.6e-97 862908010854 PS01090 Uncharacterized protein family UPF0006 signature 2. 862908010855 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908010856 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 862908010857 Signal peptide predicted for BMS2879 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.909 between residues 22 and 23 862908010858 HMMPfam hit to PF01373, Glycoside hydrolase, family 14, score 5.9e-25 862908010859 Signal peptide predicted for BMS2881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.737 between residues 19 and 20 862908010860 PGAP1-like protein; Region: PGAP1; pfam07819 862908010861 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862908010862 PS00120 Lipases, serine active site. 862908010863 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 862908010864 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 862908010865 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 862908010866 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 2.1e-67 862908010867 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 862908010868 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 6.4e-107 862908010869 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 862908010870 Phosphoglycerate kinase; Region: PGK; pfam00162 862908010871 substrate binding site [chemical binding]; other site 862908010872 hinge regions; other site 862908010873 ADP binding site [chemical binding]; other site 862908010874 catalytic site [active] 862908010875 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 2.1e-162 862908010876 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 862908010877 triosephosphate isomerase; Provisional; Region: PRK14567 862908010878 substrate binding site [chemical binding]; other site 862908010879 dimer interface [polypeptide binding]; other site 862908010880 catalytic triad [active] 862908010881 PS00228 Tubulin-beta mRNA autoregulation signal. 862908010882 HMMPfam hit to PF00121, Triosephosphate isomerase, score 5.6e-110 862908010883 PS00171 Triosephosphate isomerase active site. 862908010884 Preprotein translocase SecG subunit; Region: SecG; cl09123 862908010885 Signal peptide predicted for BMS2886 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.200 between residues 30 and 31 862908010886 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 2e-14 862908010887 2 probable transmembrane helices predicted for BMS2886 by TMHMM2.0 at aa 5-27 and 47-69 862908010888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908010889 Zn2+ binding site [ion binding]; other site 862908010890 Mg2+ binding site [ion binding]; other site 862908010891 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 2.8e-24 862908010892 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862908010893 Ligand binding site; other site 862908010894 Putative Catalytic site; other site 862908010895 DXD motif; other site 862908010896 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2e-16 862908010897 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 862908010898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862908010899 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862908010900 oxyanion hole [active] 862908010901 Signal peptide predicted for BMS2891 by SignalP 2.0 HMM (Signal peptide probability 0.911) with cleavage site probability 0.496 between residues 21 and 22 862908010902 9 probable transmembrane helices predicted for BMS2892 by TMHMM2.0 at aa 39-58, 65-87, 107-129, 141-163, 178-195, 238-260, 270-285, 292-311 and 321-338 862908010903 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 862908010904 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862908010905 dimer interface [polypeptide binding]; other site 862908010906 ssDNA binding site [nucleotide binding]; other site 862908010907 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862908010908 HMMPfam hit to PF00436, Single-strand binding protein/Primosomal replication protein n, score 3.4e-36 862908010909 PS00735 Single-strand binding protein family signature 1. 862908010910 1 probable transmembrane helix predicted for BMS2895 by TMHMM2.0 at aa 67-89 862908010911 1 probable transmembrane helix predicted for BMS2896 by TMHMM2.0 at aa 12-34 862908010912 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 862908010913 C-terminal domain interface [polypeptide binding]; other site 862908010914 GSH binding site (G-site) [chemical binding]; other site 862908010915 dimer interface [polypeptide binding]; other site 862908010916 PS00195 Glutaredoxin active site. 862908010917 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 862908010918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908010919 Zn2+ binding site [ion binding]; other site 862908010920 Mg2+ binding site [ion binding]; other site 862908010921 8 probable transmembrane helices predicted for BMS2901 by TMHMM2.0 at aa 10-32, 53-72, 87-109, 122-139, 149-168, 189-206, 221-243 and 269-291 862908010922 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862908010923 active site residue [active] 862908010924 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862908010925 MarR family; Region: MarR_2; pfam12802 862908010926 MarR family; Region: MarR_2; cl17246 862908010927 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2.7e-05 862908010928 Signal peptide predicted for BMS2905 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.862 between residues 23 and 24 862908010929 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862908010930 Signal peptide predicted for BMS2906 by SignalP 2.0 HMM (Signal peptide probability 0.706) with cleavage site probability 0.684 between residues 22 and 23 862908010931 Transposase IS200 like; Region: Y1_Tnp; cl00848 862908010932 Signal peptide predicted for BMS2910 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.467 between residues 23 and 24 862908010933 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862908010934 putative catalytic site [active] 862908010935 putative metal binding site [ion binding]; other site 862908010936 putative phosphate binding site [ion binding]; other site 862908010937 Signal peptide predicted for BMS2911 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.749 between residues 26 and 27 862908010938 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 5e-24 862908010939 Signal peptide predicted for BMS2912 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.247 between residues 32 and 33 862908010940 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 862908010941 HMMPfam hit to PF01098, Cell cycle protein, score 1.8e-103 862908010942 9 probable transmembrane helices predicted for BMS2913 by TMHMM2.0 at aa 15-34, 47-69, 73-95, 138-160, 164-181, 188-207, 276-298, 310-332 and 342-364 862908010943 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 862908010944 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 862908010945 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862908010946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862908010947 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 2.8e-91 862908010948 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010949 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.4e-40 862908010950 1 probable transmembrane helix predicted for BMS2914 by TMHMM2.0 at aa 31-50 862908010951 5 probable transmembrane helices predicted for BMS2915 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 105-127 and 140-162 862908010952 rod shape-determining protein MreC; Provisional; Region: PRK13922 862908010953 rod shape-determining protein MreC; Region: MreC; pfam04085 862908010954 HMMPfam hit to PF04085, Rod shape-determining protein MreC, score 9.6e-25 862908010955 SurA N-terminal domain; Region: SurA_N_3; cl07813 862908010956 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 862908010957 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 862908010958 Signal peptide predicted for BMS2917 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.908 between residues 43 and 44 862908010959 1 probable transmembrane helix predicted for BMS2917 by TMHMM2.0 at aa 13-35 862908010960 HMMPfam hit to PF00639, PpiC-type peptidyl-prolyl cis-trans isomerase, score 1e-19 862908010961 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 862908010962 Uncharacterized conserved protein [Function unknown]; Region: COG3379 862908010963 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 862908010964 Signal peptide predicted for BMS2919 by SignalP 2.0 HMM (Signal peptide probability 0.683) with cleavage site probability 0.260 between residues 15 and 16 862908010965 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908010966 HMMPfam hit to PF01663, Type I phosphodiesterase/nucleotide pyrophosphatase, score 5.3e-77 862908010967 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862908010968 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862908010969 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862908010970 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862908010971 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 1.4e-19 862908010972 HMMPfam hit to PF07559, Flagellar basal body FlaE, score 6.1e-18 862908010973 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 7.6e-07 862908010974 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 862908010975 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862908010976 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 862908010977 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862908010978 HMMPfam hit to PF03963, Flagellar hook capping protein, score 2.3e-24 862908010979 MgtE intracellular N domain; Region: MgtE_N; cl15244 862908010980 Signal peptide predicted for BMS2924 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.930 between residues 18 and 19 862908010981 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 862908010982 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 862908010983 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 862908010984 Walker A motif/ATP binding site; other site 862908010985 Walker B motif; other site 862908010986 HMMPfam hit to PF00006, H+-transporting two-sector ATPase, alpha/beta subunit, central region, score 4.2e-105 862908010987 PS00152 ATP synthase alpha and beta subunits signature. 862908010988 PS00017 ATP/GTP-binding site motif A (P-loop). 862908010989 flagellar assembly protein H; Validated; Region: fliH; PRK06669 862908010990 Flagellar assembly protein FliH; Region: FliH; pfam02108 862908010991 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862908010992 MgtE intracellular N domain; Region: MgtE_N; cl15244 862908010993 FliG C-terminal domain; Region: FliG_C; pfam01706 862908010994 HMMPfam hit to PF01706, Flagellar motor switch protein FliG, score 4.4e-49 862908010995 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 862908010996 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 862908010997 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 862908010998 2 probable transmembrane helices predicted for BMS2929 by TMHMM2.0 at aa 25-44 and 440-462 862908010999 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 3.7e-52 862908011000 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011001 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 862908011002 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein FliE, score 4.1e-18 862908011003 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 862908011004 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862908011005 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 8.2e-05 862908011006 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 862908011007 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 862908011008 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 5.8e-09 862908011009 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908011010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908011011 Walker A motif; other site 862908011012 ATP binding site [chemical binding]; other site 862908011013 Walker B motif; other site 862908011014 arginine finger; other site 862908011015 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908011016 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 2.1e-12 862908011017 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 4.9e-18 862908011018 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 862908011019 TPR repeat; Region: TPR_11; pfam13414 862908011020 HMMPfam hit to PF07719, , score 1.6; PF07719, Tetratricopeptide repeat 862908011021 HMMPfam hit to PF07719, , score 0.5; PF07719, Tetratricopeptide repeat 862908011022 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908011023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908011024 active site 862908011025 phosphorylation site [posttranslational modification] 862908011026 intermolecular recognition site; other site 862908011027 dimerization interface [polypeptide binding]; other site 862908011028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908011029 Walker A motif; other site 862908011030 ATP binding site [chemical binding]; other site 862908011031 Walker B motif; other site 862908011032 arginine finger; other site 862908011033 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908011034 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 4e-11 862908011035 PS00688 Sigma-54 interaction domain C-terminal part signature. 862908011036 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 7.6e-150 862908011037 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 862908011038 HMMPfam hit to PF00072, Response regulator receiver, score 6.2e-13 862908011039 2 probable transmembrane helices predicted for BMS2936 by TMHMM2.0 at aa 10-29 and 36-58 862908011040 S-adenosylmethionine synthetase; Validated; Region: PRK05250 862908011041 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 862908011042 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 862908011043 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 862908011044 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, score 8.6e-80 862908011045 PS00377 S-adenosylmethionine synthetase signature 2. 862908011046 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, score 3.5e-66 862908011047 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 862908011048 PS00376 S-adenosylmethionine synthetase signature 1. 862908011049 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, score 5.8e-56 862908011050 Signal peptide predicted for BMS2938 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.905 between residues 18 and 19 862908011051 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 862908011052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862908011053 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862908011054 HMMPfam hit to PF02875, Cytoplasmic peptidoglycan synthetases, C-terminal, score 0.00028 862908011055 HMMPfam hit to PF01225, Cytoplasmic peptidoglycan synthetase, N-terminal, score 3.3e-28 862908011056 Fic/DOC family; Region: Fic; pfam02661 862908011057 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 2.4e-06 862908011058 Signal peptide predicted for BMS2940 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.577 between residues 21 and 22 862908011059 Beta-lactamase; Region: Beta-lactamase; cl17358 862908011060 HMMPfam hit to PF00144, Beta-lactamase, score 0.0018 862908011061 pyruvate phosphate dikinase; Provisional; Region: PRK09279 862908011062 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862908011063 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862908011064 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862908011065 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 1.2e-145 862908011066 PS00742 PEP-utilizing enzymes signature 2. 862908011067 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 9.5e-40 862908011068 PS00370 PEP-utilizing enzymes phosphorylation site signature. 862908011069 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyruvate-binding, score 3.4e-160 862908011070 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011071 glycyl-tRNA synthetase; Provisional; Region: PRK04173 862908011072 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 862908011073 dimer interface [polypeptide binding]; other site 862908011074 motif 1; other site 862908011075 active site 862908011076 motif 2; other site 862908011077 motif 3; other site 862908011078 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 862908011079 anticodon binding site; other site 862908011080 HMMPfam hit to PF03129, Anticodon-binding, score 9.8e-24 862908011081 HMMPfam hit to PF00587, tRNA synthetases, class-II (G, H, P and S), score 7.8e-58 862908011082 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908011083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862908011084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862908011085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862908011086 Walker A/P-loop; other site 862908011087 ATP binding site [chemical binding]; other site 862908011088 Q-loop/lid; other site 862908011089 ABC transporter signature motif; other site 862908011090 Walker B; other site 862908011091 D-loop; other site 862908011092 H-loop/switch region; other site 862908011093 HMMPfam hit to PF00005, ABC transporter, score 4.6e-58 862908011094 PS00211 ABC transporters family signature. 862908011095 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011096 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.2e-24 862908011097 3 probable transmembrane helices predicted for BMS2945 by TMHMM2.0 at aa 20-38, 58-80 and 154-176 862908011098 Signal peptide predicted for BMS2945 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.699 between residues 36 and 37 862908011099 Signal peptide predicted for BMS2946 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.966 between residues 18 and 19 862908011100 Signal peptide predicted for BMS2948 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.784 between residues 34 and 35 862908011102 HMMPfam hit to PF00271, Helicase, C-terminal, score 0.0013 862908011103 HMMPfam hit to PF00270, DEAD/DEAH box helicase, N-terminal, score 9.4e-10 862908011104 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011105 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 862908011106 RNA methyltransferase, RsmE family; Region: TIGR00046 862908011107 HMMPfam hit to PF04452, Protein of unknown function DUF558, score 0.00029 862908011108 PS00037 Myb DNA-binding domain repeat signature 1. 862908011110 HMMPfam hit to PF00072, Response regulator receiver, score 7.1e-07 862908011111 NifU-like domain; Region: NifU; cl00484 862908011112 HMMPfam hit to PF01106, Nitrogen-fixing NifU, C-terminal, score 2.8e-20 862908011113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862908011114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862908011115 Coenzyme A binding pocket [chemical binding]; other site 862908011116 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.7e-10 862908011117 Predicted amidohydrolase [General function prediction only]; Region: COG0388 862908011118 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 862908011119 active site 862908011120 catalytic triad [active] 862908011121 dimer interface [polypeptide binding]; other site 862908011122 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 5.3e-20 862908011123 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 862908011124 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862908011125 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862908011126 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 862908011127 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 5.6e-24 862908011128 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 7.7e-49 862908011129 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 2.8e-83 862908011130 Signal peptide predicted for BMS2956 by SignalP 2.0 HMM (Signal peptide probability 0.842) with cleavage site probability 0.838 between residues 20 and 21 862908011131 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 862908011132 8 probable transmembrane helices predicted for BMS2957 by TMHMM2.0 at aa 7-29, 39-61, 81-103, 118-140, 153-175, 213-235, 248-270 and 290-312 862908011133 GTP-binding protein LepA; Provisional; Region: PRK05433 862908011134 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 862908011135 G1 box; other site 862908011136 putative GEF interaction site [polypeptide binding]; other site 862908011137 GTP/Mg2+ binding site [chemical binding]; other site 862908011138 Switch I region; other site 862908011139 G2 box; other site 862908011140 G3 box; other site 862908011141 Switch II region; other site 862908011142 G4 box; other site 862908011143 G5 box; other site 862908011144 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 862908011145 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 862908011146 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 862908011147 HMMPfam hit to PF06421, GTP-binding protein LepA, score 8.9e-80 862908011148 HMMPfam hit to PF00679, Elongation factor G, C-terminal, score 1.9e-38 862908011149 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 6.3e-11 862908011150 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 3.4e-69 862908011151 PS00301 GTP-binding elongation factors signature. 862908011152 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862908011154 dimerization interface [polypeptide binding]; other site 862908011155 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 5.9e-09 862908011156 2 probable transmembrane helices predicted for BMS2960 by TMHMM2.0 at aa 10-32 and 183-205 862908011157 PS00622 Bacterial regulatory proteins, luxR family signature. 862908011158 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 862908011159 TrkA-N domain; Region: TrkA_N; pfam02254 862908011160 TrkA-C domain; Region: TrkA_C; pfam02080 862908011161 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011162 HMMPfam hit to PF02254, TrkA-N, score 2e-24 862908011163 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 862908011164 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 862908011165 HMMPfam hit to PF02386, Cation transporter, score 3.3e-77 862908011166 13 probable transmembrane helices predicted for BMS2962 by TMHMM2.0 at aa 7-29, 44-64, 77-99, 139-161, 168-190, 205-227, 262-284, 315-337, 358-380, 419-453, 474-496, 506-528 and 535-557 862908011167 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 862908011168 HMMPfam hit to PF05958, tRNA -methyltransferase, score 1.9e-05 862908011169 TPR repeat; Region: TPR_11; pfam13414 862908011170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908011171 binding surface 862908011172 TPR motif; other site 862908011173 TPR repeat; Region: TPR_11; pfam13414 862908011174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908011175 binding surface 862908011176 TPR motif; other site 862908011177 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 862908011178 HMMPfam hit to PF07719, , score 1.5; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.19 862908011179 HMMPfam hit to PF07719, , score 0.026; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.002 862908011180 HMMPfam hit to PF00515, TPR repeat, score 0.0032; HMMPfam hit to PF07719, , score 0.36; PF07719, Tetratricopeptide repeat 862908011181 HMMPfam hit to PF00515, TPR repeat, score 0.33; HMMPfam hit to PF07719, , score 0.16; PF07719, Tetratricopeptide repeat 862908011182 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 862908011183 Helix-turn-helix domain; Region: HTH_25; pfam13413 862908011184 1 probable transmembrane helix predicted for BMS2966 by TMHMM2.0 at aa 132-154 862908011185 Predicted permeases [General function prediction only]; Region: COG0795 862908011186 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862908011187 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 1.9e-42 862908011188 6 probable transmembrane helices predicted for BMS2967 by TMHMM2.0 at aa 9-31, 57-79, 100-119, 295-317, 330-349 and 353-375 862908011189 multifunctional aminopeptidase A; Provisional; Region: PRK00913 862908011190 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862908011191 interface (dimer of trimers) [polypeptide binding]; other site 862908011192 Substrate-binding/catalytic site; other site 862908011193 Zn-binding sites [ion binding]; other site 862908011194 HMMPfam hit to PF02789, Peptidase M17, cytosol aminopeptidase, N-terminal, score 0.0054 862908011195 HMMPfam hit to PF00883, Peptidase M17, cytosol aminopeptidase, C-terminal, score 3.8e-139 862908011196 PS00631 Cytosol aminopeptidase signature. 862908011197 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 862908011198 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase (SpoU), score 1e-29 862908011199 Signal peptide predicted for BMS2971 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 22 and 23 862908011200 Signal peptide predicted for BMS2972 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 20 and 21 862908011201 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908011202 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 862908011203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908011204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908011205 catalytic residue [active] 862908011206 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862908011207 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 7.1e-08 862908011208 HMMPfam hit to PF01464, SLT, score 2.1e-25 862908011209 Signal peptide predicted for BMS2974 by SignalP 2.0 HMM (Signal peptide probability 0.710) with cleavage site probability 0.354 between residues 21 and 22 862908011210 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011211 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 8.8e-08 862908011212 2 probable transmembrane helices predicted for BMS2975 by TMHMM2.0 at aa 96-118 and 123-145 862908011213 PS00714 Sodium:dicarboxylate symporter family signature 2. 862908011214 Signal peptide predicted for BMS2975 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 41 and 42 862908011215 5 probable transmembrane helices predicted for BMS2976 by TMHMM2.0 at aa 10-32, 44-66, 81-103, 156-178 and 193-215 862908011216 Signal peptide predicted for BMS2976 by SignalP 2.0 HMM (Signal peptide probability 0.600) with cleavage site probability 0.282 between residues 35 and 36 862908011217 Signal peptide predicted for BMS2977 by SignalP 2.0 HMM (Signal peptide probability 0.820) with cleavage site probability 0.722 between residues 28 and 29 862908011218 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 862908011219 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 7.2e-102 862908011220 5 probable transmembrane helices predicted for BMS2978 by TMHMM2.0 at aa 10-32, 52-74, 89-111, 198-215 and 230-252 862908011221 PS01311 Prolipoprotein diacylglyceryl transferase signature. 862908011222 phytoene desaturase; Region: phytoene_desat; TIGR02731 862908011223 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 862908011224 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 862908011225 HMMPfam hit to PF00829, Ribosomal protein L21, score 1.2e-41 862908011226 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 862908011227 HMMPfam hit to PF01016, Ribosomal protein L27, score 1.5e-34 862908011228 GTPase CgtA; Reviewed; Region: obgE; PRK12299 862908011229 GTP1/OBG; Region: GTP1_OBG; pfam01018 862908011230 Obg GTPase; Region: Obg; cd01898 862908011231 G1 box; other site 862908011232 GTP/Mg2+ binding site [chemical binding]; other site 862908011233 Switch I region; other site 862908011234 G2 box; other site 862908011235 G3 box; other site 862908011236 Switch II region; other site 862908011237 G4 box; other site 862908011238 G5 box; other site 862908011239 HMMPfam hit to PF01018, GTP1/OBG subdomain, score 6.1e-78 862908011240 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.4e-36 862908011241 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011242 Oligomerisation domain; Region: Oligomerisation; pfam02410 862908011243 HMMPfam hit to PF02410, Iojap-related protein, score 3.1e-24 862908011244 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 862908011245 HMMPfam hit to PF02590, Protein of unknown function DUF163, score 2.2e-36 862908011246 9 probable transmembrane helices predicted for BMS2988 by TMHMM2.0 at aa 13-35, 88-107, 114-133, 137-154, 166-188, 198-217, 263-282, 292-311 and 318-336 862908011247 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 862908011248 Asparagine synthase; Region: Asn_synthase; pfam00733 862908011249 HMMPfam hit to PF00733, Asparagine synthase, score 5.9e-07 862908011250 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 862908011251 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862908011252 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 862908011253 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 9.7e-19 862908011254 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 2.2e-26 862908011255 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862908011256 Ligand binding site; other site 862908011257 Putative Catalytic site; other site 862908011258 DXD motif; other site 862908011259 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.3e-15 862908011260 2 probable transmembrane helices predicted for BMS2991 by TMHMM2.0 at aa 236-255 and 260-277 862908011261 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 862908011262 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862908011263 active site 862908011264 dimer interface [polypeptide binding]; other site 862908011265 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862908011266 Ligand Binding Site [chemical binding]; other site 862908011267 Molecular Tunnel; other site 862908011268 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 7.4e-13 862908011269 HMMPfam hit to PF00733, Asparagine synthase, score 6.6e-41 862908011270 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 862908011271 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 862908011272 active site 862908011273 HIGH motif; other site 862908011274 dimer interface [polypeptide binding]; other site 862908011275 KMSKS motif; other site 862908011276 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 5.1e-32 862908011277 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011278 Signal peptide predicted for BMS2995 by SignalP 2.0 HMM (Signal peptide probability 0.820) with cleavage site probability 0.410 between residues 30 and 31 862908011279 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908011280 Signal peptide predicted for BMS2996 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 29 and 30 862908011281 von Willebrand factor; Region: vWF_A; pfam12450 862908011282 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 862908011283 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 862908011284 metal ion-dependent adhesion site (MIDAS); other site 862908011285 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 862908011286 PS00435 Peroxidases proximal heme-ligand signature. 862908011287 HMMPfam hit to PF00092, von Willebrand factor, type A, score 6.5e-22 862908011288 1 probable transmembrane helix predicted for BMS2997 by TMHMM2.0 at aa 83-105 862908011289 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862908011290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862908011291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862908011292 DNA binding residues [nucleotide binding] 862908011293 HMMPfam hit to PF04542, Sigma-70 region 2, score 6.7e-09 862908011294 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908011295 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862908011296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908011297 dimer interface [polypeptide binding]; other site 862908011298 conserved gate region; other site 862908011299 putative PBP binding loops; other site 862908011300 ABC-ATPase subunit interface; other site 862908011301 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.1e-43 862908011302 6 probable transmembrane helices predicted for BMS3001 by TMHMM2.0 at aa 40-62, 101-123, 135-157, 162-181, 216-238 and 266-288 862908011303 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862908011304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908011305 dimer interface [polypeptide binding]; other site 862908011306 conserved gate region; other site 862908011307 putative PBP binding loops; other site 862908011308 ABC-ATPase subunit interface; other site 862908011309 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.3e-46 862908011310 6 probable transmembrane helices predicted for BMS3002 by TMHMM2.0 at aa 27-49, 119-141, 150-172, 192-209, 250-272 and 300-322 862908011311 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908011312 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862908011313 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 862908011314 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 6.8e-72 862908011315 Signal peptide predicted for BMS3003 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.593 between residues 22 and 23 862908011316 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908011318 binding surface 862908011319 TPR motif; other site 862908011320 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908011321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908011322 binding surface 862908011323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908011324 TPR motif; other site 862908011325 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908011326 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908011327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908011328 binding surface 862908011329 TPR motif; other site 862908011330 HMMPfam hit to PF00515, TPR repeat, score 0.19 862908011331 HMMPfam hit to PF07719, , score 1.6; PF07719, Tetratricopeptide repeat 862908011332 HMMPfam hit to PF00515, TPR repeat, score 1.1; HMMPfam hit to PF07719, , score 0.27; PF07719, Tetratricopeptide repeat 862908011333 HMMPfam hit to PF07719, , score 2; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.36 862908011334 HMMPfam hit to PF00515, TPR repeat, score 1.3; HMMPfam hit to PF07719, , score 1.1; PF07719, Tetratricopeptide repeat 862908011335 HMMPfam hit to PF00515, TPR repeat, score 0.36 862908011336 HMMPfam hit to PF07719, , score 0.0032; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.3 862908011337 HMMPfam hit to PF00515, TPR repeat, score 0.038; HMMPfam hit to PF07719, , score 0.0029; PF07719, Tetratricopeptide repeat 862908011338 HMMPfam hit to PF00515, TPR repeat, score 0.24; HMMPfam hit to PF07719, , score 0.38; PF07719, Tetratricopeptide repeat 862908011339 Signal peptide predicted for BMS3005 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.579 between residues 23 and 24 862908011340 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 862908011341 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 862908011342 Signal peptide predicted for BMS3007 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 26 and 27 862908011343 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011344 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 862908011345 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 862908011346 P loop; other site 862908011347 Nucleotide binding site [chemical binding]; other site 862908011348 DTAP/Switch II; other site 862908011349 Switch I; other site 862908011350 HMMPfam hit to PF02374, Anion-transporting ATPase, score 1.5e-07 862908011351 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011352 Glutamate-cysteine ligase; Region: GshA; pfam08886 862908011353 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 862908011354 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 862908011355 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 862908011356 dimer interface [polypeptide binding]; other site 862908011357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908011358 catalytic residue [active] 862908011359 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862908011360 HMMPfam hit to PF00291, Pyridoxal-5'-phosphate-dependent enzyme, beta subunit, score 1.1e-94 862908011361 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011362 HMMPfam hit to PF00571, CBS, score 9.9e-10 862908011363 HMMPfam hit to PF00571, CBS, score 0.5 862908011364 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 862908011365 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862908011366 homodimer interface [polypeptide binding]; other site 862908011367 substrate-cofactor binding pocket; other site 862908011368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908011369 catalytic residue [active] 862908011370 HMMPfam hit to PF01053, Cys/Met metabolism pyridoxal-phosphate-dependent enzymes, score 1.4e-219 862908011371 Signal peptide predicted for BMS3013 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.517 between residues 24 and 25 862908011372 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862908011373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908011374 Zn2+ binding site [ion binding]; other site 862908011375 Mg2+ binding site [ion binding]; other site 862908011376 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 2.4e-25 862908011377 1 probable transmembrane helix predicted for BMS3016 by TMHMM2.0 at aa 90-109 862908011378 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 862908011379 active site 862908011380 intersubunit interface [polypeptide binding]; other site 862908011381 Zn2+ binding site [ion binding]; other site 862908011382 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908011383 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 862908011384 dinuclear metal binding motif [ion binding]; other site 862908011385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 862908011386 ATP binding site [chemical binding]; other site 862908011387 putative Mg++ binding site [ion binding]; other site 862908011388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862908011389 nucleotide binding region [chemical binding]; other site 862908011390 ATP-binding site [chemical binding]; other site 862908011391 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 862908011392 PS00018 EF-hand calcium-binding domain. 862908011393 HMMPfam hit to PF00271, Helicase, C-terminal, score 3.4e-15 862908011394 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011395 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 862908011396 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 862908011397 Peptidase family M28; Region: Peptidase_M28; pfam04389 862908011398 active site 862908011399 metal binding site [ion binding]; metal-binding site 862908011400 HMMPfam hit to PF04389, Peptidase M28, score 4.8e-37 862908011401 Signal peptide predicted for BMS3021 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.969 between residues 58 and 59 862908011402 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 862908011403 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862908011404 FMN binding site [chemical binding]; other site 862908011405 substrate binding site [chemical binding]; other site 862908011406 putative catalytic residue [active] 862908011407 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, NPD, score 2.2e-32 862908011408 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 862908011409 active site 862908011410 ligand binding site [chemical binding]; other site 862908011411 homodimer interface [polypeptide binding]; other site 862908011412 NAD(P) binding site [chemical binding]; other site 862908011413 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal, score 1.9e-15 862908011414 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal, score 1.3e-18 862908011415 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 862908011416 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 862908011417 active site 862908011418 Zn binding site [ion binding]; other site 862908011419 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 3.3e-168 862908011420 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908011421 PS00157 Ribulose bisphosphate carboxylase large chain active site. 862908011422 TLC ATP/ADP transporter; Region: TLC; cl03940 862908011423 10 probable transmembrane helices predicted for BMS3025 by TMHMM2.0 at aa 24-46, 61-78, 90-109, 114-136, 149-171, 175-197, 230-252, 272-294, 301-323 and 386-408 862908011424 Signal peptide predicted for BMS3025 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.884 between residues 45 and 46 862908011425 Signal peptide predicted for BMS3026 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.971 between residues 21 and 22 862908011426 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 862908011427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862908011428 putative DNA binding site [nucleotide binding]; other site 862908011429 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 862908011430 HMMPfam hit to PF02742, Iron dependent repressor, score 1e-07 862908011431 Signal peptide predicted for BMS3028 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.630 between residues 22 and 23 862908011432 Protein of unknown function, DUF393; Region: DUF393; cl01136 862908011433 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 862908011434 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 862908011435 Ligand binding site; other site 862908011436 Putative Catalytic site; other site 862908011437 DXD motif; other site 862908011438 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 4.9e-27 862908011439 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 862908011440 Zn binding site [ion binding]; other site 862908011441 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908011442 Signal peptide predicted for BMS3031 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.989 between residues 18 and 19 862908011443 6 probable transmembrane helices predicted for BMS3032 by TMHMM2.0 at aa 7-29, 39-58, 70-92, 129-150, 170-187 and 197-216 862908011444 PS00881 Protein splicing signature. 862908011445 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 862908011446 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 2.9e-32 862908011447 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 862908011448 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 862908011449 homotetramer interface [polypeptide binding]; other site 862908011450 ligand binding site [chemical binding]; other site 862908011451 catalytic site [active] 862908011452 NAD binding site [chemical binding]; other site 862908011453 HMMPfam hit to PF05221, S-adenosyl-L-homocysteine hydrolase, score 3.4e-148 862908011454 HMMPfam hit to PF00670, S-adenosyl-L-homocysteine hydrolase, score 4.1e-108 862908011455 PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 862908011456 PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 862908011457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862908011458 Phosphotransferase enzyme family; Region: APH; pfam01636 862908011459 active site 862908011460 substrate binding site [chemical binding]; other site 862908011461 ATP binding site [chemical binding]; other site 862908011462 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 3.4e-14 862908011463 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 862908011464 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 862908011465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908011466 HMMPfam hit to PF01170, Putative RNA methylase, score 5.9e-33 862908011467 PS01261 Uncharacterized protein family UPF0020 signature. 862908011468 PS00092 N-6 Adenine-specific DNA methylases signature. 862908011469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908011470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908011471 active site 862908011472 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862908011473 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 1.5e-41 862908011474 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 1.5e-20 862908011475 PS00072 Acyl-CoA dehydrogenases signature 1. 862908011476 Signal peptide predicted for BMS3039 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.315 between residues 23 and 24 862908011477 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 862908011478 phosphoglyceromutase; Provisional; Region: PRK05434 862908011479 HMMPfam hit to PF06415, BPG-independent PGAM, N-terminal, score 4.2e-157 862908011480 HMMPfam hit to PF01676, Metalloenzyme, score 1.8e-39 862908011481 6-phosphofructokinase; Provisional; Region: PRK03202 862908011482 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 862908011483 active site 862908011484 ADP/pyrophosphate binding site [chemical binding]; other site 862908011485 dimerization interface [polypeptide binding]; other site 862908011486 allosteric effector site; other site 862908011487 fructose-1,6-bisphosphate binding site; other site 862908011488 HMMPfam hit to PF00365, Phosphofructokinase, score 3.9e-134 862908011489 Mg chelatase-related protein; Region: TIGR00368 862908011490 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862908011491 active site 862908011492 Signal peptide predicted for BMS3043 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.560 between residues 21 and 22 862908011493 PS00134 Serine proteases, trypsin family, histidine active site. 862908011494 Signal peptide predicted for BMS3044 by SignalP 2.0 HMM (Signal peptide probability 0.795) with cleavage site probability 0.766 between residues 21 and 22 862908011495 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 862908011496 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 862908011497 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 862908011498 NAD(P) binding site [chemical binding]; other site 862908011499 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C terminal, score 1.7e-92 862908011500 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 3.1e-70 862908011501 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 862908011502 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 862908011503 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 862908011504 ParB-like nuclease domain; Region: ParB; smart00470 862908011505 HMMPfam hit to PF02195, ParB-like nuclease, score 1.9e-17 862908011506 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862908011507 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908011508 P-loop; other site 862908011509 Magnesium ion binding site [ion binding]; other site 862908011510 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908011511 Magnesium ion binding site [ion binding]; other site 862908011512 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 2.7e-29 862908011513 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862908011514 active site residue [active] 862908011515 HMMPfam hit to PF00581, Rhodanese-like, score 3.1e-15 862908011516 quinolinate synthetase; Provisional; Region: PRK09375 862908011517 HMMPfam hit to PF02445, Quinolinate synthetase A, score 2.3e-120 862908011518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908011519 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862908011520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908011521 catalytic residue [active] 862908011522 HMMPfam hit to PF00266, Aminotransferase, class V, score 2.1e-31 862908011523 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 862908011524 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 862908011525 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862908011526 active site 862908011527 metal binding site [ion binding]; metal-binding site 862908011528 Signal peptide predicted for BMS3055 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.394 between residues 32 and 33 862908011529 PrkA AAA domain; Region: AAA_PrkA; smart00763 862908011530 AAA ATPase domain; Region: AAA_16; pfam13191 862908011531 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 862908011532 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862908011533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862908011534 RNA binding surface [nucleotide binding]; other site 862908011535 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862908011536 active site 862908011537 HMMPfam hit to PF00849, Pseudouridine synthase, score 4.2e-25 862908011538 PS01129 Rlu family of pseudouridine synthase signature. 862908011539 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 862908011540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862908011541 active site 862908011542 motif I; other site 862908011543 motif II; other site 862908011544 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 862908011545 Signal peptide predicted for BMS3059 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 24 and 25 862908011546 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 862908011547 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 862908011548 HMMPfam hit to PF03055, Retinal pigment epithelial membrane protein, score 6.3e-52 862908011549 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 862908011550 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908011551 ATP binding site [chemical binding]; other site 862908011552 Walker B motif; other site 862908011553 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 1.1e-16 862908011554 PS00662 Bacterial type II secretion system protein E signature. 862908011555 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011556 3 probable transmembrane helices predicted for BMS3066 by TMHMM2.0 at aa 10-32, 55-77 and 87-109 862908011557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 862908011558 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 862908011559 APO RNA-binding; Region: APO_RNA-bind; cl10644 862908011560 2 probable transmembrane helices predicted for BMS3067 by TMHMM2.0 at aa 5-27 and 40-62 862908011561 HMMPfam hit to PF01145, Band 7 protein, score 5.4e-17 862908011562 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 862908011563 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 862908011564 7 probable transmembrane helices predicted for BMS3068 by TMHMM2.0 at aa 24-41, 45-67, 88-110, 120-142, 147-169, 199-221 and 238-260 862908011565 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862908011566 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862908011567 Walker A/P-loop; other site 862908011568 ATP binding site [chemical binding]; other site 862908011569 Q-loop/lid; other site 862908011570 ABC transporter signature motif; other site 862908011571 Walker B; other site 862908011572 D-loop; other site 862908011573 H-loop/switch region; other site 862908011574 HMMPfam hit to PF00005, ABC transporter, score 3.1e-49 862908011575 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862908011577 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862908011578 putative DNA binding site [nucleotide binding]; other site 862908011579 putative Zn2+ binding site [ion binding]; other site 862908011580 AsnC family; Region: AsnC_trans_reg; pfam01037 862908011581 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 1.2e-37 862908011582 PS00519 Bacterial regulatory proteins, asnC family signature. 862908011583 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 862908011584 5 probable transmembrane helices predicted for BMS3071 by TMHMM2.0 at aa 7-29, 39-61, 64-86, 142-164 and 177-196 862908011585 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 1.6e-06 862908011586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908011587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908011588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862908011589 dimerization interface [polypeptide binding]; other site 862908011590 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.2e-08 862908011591 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.8e-09 862908011592 1 probable transmembrane helix predicted for BMS3073 by TMHMM2.0 at aa 5-27 862908011593 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 862908011594 dimer interface [polypeptide binding]; other site 862908011595 FMN binding site [chemical binding]; other site 862908011596 NADPH bind site [chemical binding]; other site 862908011597 HMMPfam hit to PF00881, Nitroreductase, score 1.1e-38 862908011598 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 862908011599 HMMPfam hit to PF03553, Na+/H+ antiporter NhaC, score 8.1e-36 862908011600 10 probable transmembrane helices predicted for BMS3075 by TMHMM2.0 at aa 7-29, 39-58, 79-101, 121-143, 201-220, 230-252, 254-276, 335-357, 377-399 and 409-431 862908011601 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 862908011602 HMMPfam hit to PF07237, Protein of unknown function DUF1428, score 3.3e-60 862908011603 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 862908011604 Signal peptide predicted for BMS3078 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.588 between residues 18 and 19 862908011605 PS00261 Glycoprotein hormones beta chain signature 1. 862908011606 1 probable transmembrane helix predicted for BMS3080 by TMHMM2.0 at aa 20-38 862908011607 YceI-like domain; Region: YceI; pfam04264 862908011608 Signal peptide predicted for BMS3081 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 18 and 19 862908011609 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862908011610 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 862908011611 putative acyl-acceptor binding pocket; other site 862908011612 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 0.0025 862908011613 HMMPfam hit to PF04028, Protein of unknown function DUF374, score 1.1e-13 862908011614 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 862908011615 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 862908011616 Signal peptide predicted for BMS3084 by SignalP 2.0 HMM (Signal peptide probability 0.877) with cleavage site probability 0.611 between residues 21 and 22 862908011617 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 862908011618 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 862908011619 trimer interface [polypeptide binding]; other site 862908011620 putative metal binding site [ion binding]; other site 862908011621 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.45 862908011622 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.9 862908011623 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.7 862908011624 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 27 862908011625 HMMPfam hit to PF00034, Cytochrome c, class I, score 0.00017 862908011626 PS00190 Cytochrome c family heme-binding site signature. 862908011627 Signal peptide predicted for BMS3086 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.872 between residues 18 and 19 862908011628 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 862908011629 HMMPfam hit to PF03641, Conserved hypothetical protein 730, score 1.2e-48 862908011630 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 862908011631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862908011632 RNA binding surface [nucleotide binding]; other site 862908011633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908011634 S-adenosylmethionine binding site [chemical binding]; other site 862908011635 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 1.7e-08 862908011636 HMMPfam hit to PF01479, RNA-binding S4, score 3.1e-08 862908011637 Signal peptide predicted for BMS3088 by SignalP 2.0 HMM (Signal peptide probability 0.737) with cleavage site probability 0.716 between residues 21 and 22 862908011638 1 probable transmembrane helix predicted for BMS3089 by TMHMM2.0 at aa 10-32 862908011639 Signal peptide predicted for BMS3089 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 24 and 25 862908011640 VanZ like family; Region: VanZ; cl01971 862908011641 3 probable transmembrane helices predicted for BMS3090 by TMHMM2.0 at aa 4-26, 64-86 and 96-118 862908011642 HMMPfam hit to PF04892, VanZ like protein, score 1.4e-07 862908011643 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 862908011644 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 862908011645 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 862908011646 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 7.8e-28 862908011647 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011648 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 1.1e-19 862908011649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908011650 non-specific DNA binding site [nucleotide binding]; other site 862908011651 salt bridge; other site 862908011652 sequence-specific DNA binding site [nucleotide binding]; other site 862908011653 HMMPfam hit to PF01381, Helix-turn-helix motif, score 1.5e-15 862908011654 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 862908011655 PS00011 Vitamin K-dependent carboxylation domain. 862908011656 Cupin domain; Region: Cupin_2; cl17218 862908011657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908011658 active site 862908011659 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 1.7e-09 862908011660 Protein of unknown function, DUF462; Region: DUF462; pfam04315 862908011661 HMMPfam hit to PF04315, Protein of unknown function DUF462, score 7.1e-46 862908011662 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 862908011663 oxyanion hole [active] 862908011664 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862908011665 catalytic triad [active] 862908011666 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011668 FeS/SAM binding site; other site 862908011669 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908011670 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862908011671 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862908011672 inhibitor-cofactor binding pocket; inhibition site 862908011673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862908011674 catalytic residue [active] 862908011675 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 4.1e-72 862908011676 PS01305 moaA / nifB / pqqE family signature. 862908011677 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862908011678 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 862908011679 NAD(P) binding site [chemical binding]; other site 862908011680 HMMPfam hit to PF00107, Zinc-containing alcohol dehydrogenase superfamily, score 7.8e-32 862908011681 PS00059 Zinc-containing alcohol dehydrogenases signature. 862908011682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011683 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011684 FeS/SAM binding site; other site 862908011685 HMMPfam hit to PF04055, Radical SAM, score 3.5e-19 862908011686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011687 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011688 FeS/SAM binding site; other site 862908011689 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908011690 HMMPfam hit to PF04055, Radical SAM, score 1.8e-16 862908011691 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 862908011692 Predicted amidohydrolase [General function prediction only]; Region: COG0388 862908011693 putative active site [active] 862908011694 catalytic triad [active] 862908011695 putative dimer interface [polypeptide binding]; other site 862908011696 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 1.9e-17 862908011697 Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; Region: START; cd00177 862908011698 lipid binding site [chemical binding]; lipid-binding site 862908011699 Signal peptide predicted for BMS3110 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.907 between residues 18 and 19 862908011700 11 probable transmembrane helices predicted for BMS3112 by TMHMM2.0 at aa 7-26, 113-135, 142-159, 198-220, 233-250, 277-299, 311-333, 337-359, 366-385, 428-446 and 458-480 862908011701 PS01222 PMP-22 / EMP / MP20 family signature 2. 862908011702 Signal peptide predicted for BMS3112 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.519 between residues 25 and 26 862908011703 9 probable transmembrane helices predicted for BMS3113 by TMHMM2.0 at aa 16-38, 130-152, 159-181, 211-233, 240-262, 318-340, 347-364, 374-393 and 402-424 862908011704 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 862908011705 Signal peptide predicted for BMS3116 by SignalP 2.0 HMM (Signal peptide probability 0.666) with cleavage site probability 0.276 between residues 32 and 33 862908011706 PS00190 Cytochrome c family heme-binding site signature. 862908011707 PS00190 Cytochrome c family heme-binding site signature. 862908011708 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 862908011709 active site 862908011710 oxyanion hole [active] 862908011711 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862908011712 catalytic triad [active] 862908011713 1 probable transmembrane helix predicted for BMS3117 by TMHMM2.0 at aa 7-29 862908011714 Signal peptide predicted for BMS3118 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.571 between residues 20 and 21 862908011715 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 862908011716 active site 862908011717 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 862908011718 active site 862908011719 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 862908011720 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 862908011721 active site 862908011722 oxyanion hole [active] 862908011723 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862908011724 catalytic triad [active] 862908011725 1 probable transmembrane helix predicted for BMS3120 by TMHMM2.0 at aa 21-43 862908011726 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908011727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011728 FeS/SAM binding site; other site 862908011729 HMMPfam hit to PF04055, Radical SAM, score 1.2e-08 862908011730 PS01305 moaA / nifB / pqqE family signature. 862908011731 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862908011732 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908011733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908011734 catalytic residue [active] 862908011735 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908011736 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862908011737 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.3e-10 862908011738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908011739 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862908011740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908011741 catalytic residue [active] 862908011742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011743 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011744 FeS/SAM binding site; other site 862908011745 HMMPfam hit to PF04055, Radical SAM, score 3.9e-16 862908011746 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862908011747 Ligand binding site; other site 862908011748 Putative Catalytic site; other site 862908011749 DXD motif; other site 862908011750 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1e-16 862908011751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011752 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011753 FeS/SAM binding site; other site 862908011754 1 probable transmembrane helix predicted for BMS3126 by TMHMM2.0 at aa 12-34 862908011755 HMMPfam hit to PF04055, Radical SAM, score 4.7e-15 862908011756 1 probable transmembrane helix predicted for BMS3127 by TMHMM2.0 at aa 15-32 862908011757 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 862908011758 8 probable transmembrane helices predicted for BMS3128 by TMHMM2.0 at aa 20-42, 94-113, 118-140, 182-204, 216-238, 253-271, 280-302 and 306-328 862908011759 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908011760 PS00226 Intermediate filaments signature. 862908011761 11 probable transmembrane helices predicted for BMS3129 by TMHMM2.0 at aa 13-35, 82-104, 117-139, 143-162, 169-191, 211-230, 237-256, 276-298, 305-327, 337-354 and 359-381 862908011762 Signal peptide predicted for BMS3129 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.658 between residues 27 and 28 862908011763 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 862908011764 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 862908011765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011766 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 862908011767 FeS/SAM binding site; other site 862908011768 HMMPfam hit to PF04055, Radical SAM, score 7.2e-06 862908011769 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 862908011770 1 probable transmembrane helix predicted for BMS3133 by TMHMM2.0 at aa 13-35 862908011771 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011773 FeS/SAM binding site; other site 862908011774 HMMPfam hit to PF04055, Radical SAM, score 8.1e-09 862908011775 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 862908011776 extended (e) SDRs; Region: SDR_e; cd08946 862908011777 NAD(P) binding site [chemical binding]; other site 862908011778 active site 862908011779 substrate binding site [chemical binding]; other site 862908011780 Thioredoxin; Region: Thioredoxin_4; cl17273 862908011781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011782 Signal peptide predicted for BMS3137 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.876 between residues 31 and 32 862908011783 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908011784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908011785 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 3.2e-09 862908011786 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 862908011787 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 862908011788 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 862908011789 Walker A/P-loop; other site 862908011790 ATP binding site [chemical binding]; other site 862908011791 Q-loop/lid; other site 862908011792 ABC transporter signature motif; other site 862908011793 Walker B; other site 862908011794 D-loop; other site 862908011795 H-loop/switch region; other site 862908011796 HMMPfam hit to PF00005, ABC transporter, score 3.3e-31 862908011797 PS00211 ABC transporters family signature. 862908011798 PS00017 ATP/GTP-binding site motif A (P-loop). 862908011799 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 862908011800 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 862908011801 6 probable transmembrane helices predicted for BMS3142 by TMHMM2.0 at aa 29-51, 61-83, 104-126, 136-158, 171-193 and 224-246 862908011802 HMMPfam hit to PF01061, ABC-2, score 2.4e-13 862908011803 PS00890 ABC-2 type transport system integral membrane proteins signature. 862908011804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862908011805 Catalytic site [active] 862908011806 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, score 0.0015 862908011807 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908011808 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 862908011809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011810 FeS/SAM binding site; other site 862908011811 HMMPfam hit to PF04055, Radical SAM, score 5.8e-11 862908011812 PS00190 Cytochrome c family heme-binding site signature. 862908011813 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908011814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908011815 FeS/SAM binding site; other site 862908011816 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 862908011817 HMMPfam hit to PF04055, Radical SAM, score 5.4e-06 862908011818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862908011819 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908011820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862908011821 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 4.8e-05 862908011822 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 862908011823 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 862908011824 HMMPfam hit to PF02543, Carbamoyltransferase, score 7.7e-35 862908011825 Signal peptide predicted for BMS3147 by SignalP 2.0 HMM (Signal peptide probability 0.610) with cleavage site probability 0.339 between residues 24 and 25 862908011826 sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323 862908011827 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862908011828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862908011829 S-adenosylmethionine binding site [chemical binding]; other site 862908011830 sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324 862908011831 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 862908011832 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862908011833 PYR/PP interface [polypeptide binding]; other site 862908011834 dimer interface [polypeptide binding]; other site 862908011835 TPP binding site [chemical binding]; other site 862908011836 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862908011837 HMMPfam hit to PF02780, Transketolase, C terminal, score 9.9e-07 862908011838 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 862908011839 HMMPfam hit to PF02779, Transketolase, central region, score 3.3e-14 862908011840 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862908011841 TPP-binding site [chemical binding]; other site 862908011842 dimer interface [polypeptide binding]; other site 862908011843 HMMPfam hit to PF00456, Transketolase, N terminal, score 3.1e-15 862908011844 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908011845 extended (e) SDRs; Region: SDR_e; cd08946 862908011846 NAD(P) binding site [chemical binding]; other site 862908011847 active site 862908011848 substrate binding site [chemical binding]; other site 862908011849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908011850 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 3.7e-14 862908011851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908011852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908011853 NAD(P) binding site [chemical binding]; other site 862908011854 active site 862908011855 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 6.7e-65 862908011856 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862908011857 active site 862908011858 nucleotide binding site [chemical binding]; other site 862908011859 HIGH motif; other site 862908011860 KMSKS motif; other site 862908011861 HMMPfam hit to PF01467, Cytidylyltransferase, score 8.4e-06 862908011862 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 862908011863 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 862908011864 putative active site [active] 862908011865 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 3.1e-27 862908011866 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 862908011867 active site 862908011868 dimer interface [polypeptide binding]; other site 862908011869 metal binding site [ion binding]; metal-binding site 862908011870 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 8.9e-79 862908011871 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 862908011872 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 862908011873 Tetramer interface [polypeptide binding]; other site 862908011874 active site 862908011875 FMN-binding site [chemical binding]; other site 862908011876 HMMPfam hit to PF01264, Chorismate synthase, score 9.7e-118 862908011877 PS00789 Chorismate synthase signature 3. 862908011878 PS00788 Chorismate synthase signature 2. 862908011879 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 862908011880 Putative zinc ribbon domain; Region: DUF164; pfam02591 862908011881 HMMPfam hit to PF02591, Protein of unknown function DUF164, score 4.5e-05 862908011882 Outer membrane efflux protein; Region: OEP; pfam02321 862908011883 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.3e-05 862908011884 Signal peptide predicted for BMS3162 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.923 between residues 19 and 20 862908011885 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 862908011886 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862908011887 minor groove reading motif; other site 862908011888 helix-hairpin-helix signature motif; other site 862908011889 substrate binding pocket [chemical binding]; other site 862908011890 active site 862908011891 HMMPfam hit to PF00730, HhH-GPD, score 3.5e-16 862908011892 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.9e-06 862908011893 Signal peptide predicted for BMS3164 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.985 between residues 17 and 18 862908011894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862908011895 non-specific DNA binding site [nucleotide binding]; other site 862908011896 salt bridge; other site 862908011897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862908011898 sequence-specific DNA binding site [nucleotide binding]; other site 862908011899 HMMPfam hit to PF01381, Helix-turn-helix motif, score 2.2e-05 862908011900 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862908011901 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908011902 L-aspartate oxidase; Provisional; Region: PRK06175 862908011903 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 862908011904 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862908011905 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 3e-130 862908011906 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 862908011907 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 862908011908 dimerization interface [polypeptide binding]; other site 862908011909 active site 862908011910 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, score 3.2e-61 862908011911 8 probable transmembrane helices predicted for BMS3171 by TMHMM2.0 at aa 7-26, 84-106, 119-138, 158-177, 186-208, 212-234, 241-263 and 278-300 862908011912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908011914 ATP binding site [chemical binding]; other site 862908011915 Mg2+ binding site [ion binding]; other site 862908011916 G-X-G motif; other site 862908011917 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.6e-24 862908011918 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0049 862908011919 2 probable transmembrane helices predicted for BMS3173 by TMHMM2.0 at aa 10-32 and 139-161 862908011920 Signal peptide predicted for BMS3173 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.459 between residues 32 and 33 862908011921 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862908011922 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862908011923 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 0.00011 862908011924 Signal peptide predicted for BMS3174 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.740 between residues 26 and 27 862908011925 HEXXH motif domain; Region: mod_HExxH; TIGR04267 862908011926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908011927 NAD(P) binding site [chemical binding]; other site 862908011928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862908011929 active site 862908011930 Signal peptide predicted for BMS3177 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 862908011931 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 862908011932 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862908011933 TPP-binding site [chemical binding]; other site 862908011934 tetramer interface [polypeptide binding]; other site 862908011935 heterodimer interface [polypeptide binding]; other site 862908011936 phosphorylation loop region [posttranslational modification] 862908011937 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862908011938 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862908011939 alpha subunit interface [polypeptide binding]; other site 862908011940 TPP binding site [chemical binding]; other site 862908011941 heterodimer interface [polypeptide binding]; other site 862908011942 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862908011943 HMMPfam hit to PF02780, Transketolase, C terminal, score 5.6e-39 862908011944 HMMPfam hit to PF02779, Transketolase, central region, score 4.6e-52 862908011945 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 5.1e-40 862908011946 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908011947 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 862908011948 Signal peptide predicted for BMS3180 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 26 and 27 862908011949 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 862908011950 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 862908011951 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 862908011952 NAD binding site [chemical binding]; other site 862908011953 Phe binding site; other site 862908011954 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C terminal, score 2.5e-37 862908011955 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 1.3e-53 862908011956 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 862908011957 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 862908011958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862908011959 catalytic loop [active] 862908011960 iron binding site [ion binding]; other site 862908011961 HMMPfam hit to PF00111, Ferredoxin, score 1.4e-09 862908011962 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 862908011963 Signal peptide predicted for BMS3183 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.800 between residues 15 and 16 862908011964 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862908011965 HMMPfam hit to PF00070, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 3e-11 862908011966 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 862908011967 Domain of unknown function DUF21; Region: DUF21; pfam01595 862908011968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862908011969 Transporter associated domain; Region: CorC_HlyC; smart01091 862908011970 HMMPfam hit to PF03471, Transporter-associated region, score 3.5e-08 862908011971 HMMPfam hit to PF00571, CBS, score 1.5e-09 862908011972 HMMPfam hit to PF00571, CBS, score 1.9e-06 862908011973 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 3e-38 862908011974 3 probable transmembrane helices predicted for BMS3185 by TMHMM2.0 at aa 49-71, 81-99 and 119-141 862908011975 1 probable transmembrane helix predicted for BMS3186 by TMHMM2.0 at aa 71-93 862908011976 8 probable transmembrane helices predicted for BMS3187 by TMHMM2.0 at aa 5-27, 39-61, 65-82, 89-106, 121-143, 155-174, 194-216 and 228-250 862908011977 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 862908011978 nudix motif; other site 862908011979 HMMPfam hit to PF00293, NUDIX hydrolase, score 6e-10 862908011980 PS00893 mutT domain signature. 862908011981 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 862908011982 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862908011983 FMN binding site [chemical binding]; other site 862908011984 active site 862908011985 catalytic residues [active] 862908011986 substrate binding site [chemical binding]; other site 862908011987 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 8.2e-39 862908011988 PS01136 Uncharacterized protein family UPF0034 signature. 862908011989 4 probable transmembrane helices predicted for BMS3190 by TMHMM2.0 at aa 7-29, 33-52, 65-87 and 102-124 862908011990 Signal peptide predicted for BMS3191 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.590 between residues 18 and 19 862908011991 Signal peptide predicted for BMS3192 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 18 and 19 862908011992 phosphodiesterase; Provisional; Region: PRK12704 862908011993 KH domain; Region: KH_1; pfam00013 862908011994 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862908011995 Zn2+ binding site [ion binding]; other site 862908011996 Mg2+ binding site [ion binding]; other site 862908011997 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD subdomain, score 2.6e-20 862908011998 HMMPfam hit to PF00013, KH, type 1, score 5.2e-09 862908011999 PS00215 Mitochondrial energy transfer proteins signature. 862908012000 Signal peptide predicted for BMS3193 by SignalP 2.0 HMM (Signal peptide probability 0.843) with cleavage site probability 0.691 between residues 28 and 29 862908012001 1 probable transmembrane helix predicted for BMS3193 by TMHMM2.0 at aa 5-23 862908012002 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 862908012003 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 862908012004 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 5.5e-26 862908012005 Cell division protein ZapA; Region: ZapA; pfam05164 862908012006 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 862908012007 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 862908012008 P loop; other site 862908012009 GTP binding site [chemical binding]; other site 862908012010 HMMPfam hit to PF00448, GTP-binding signal recognition particle SRP54, G-domain, score 2.2e-101 862908012011 PS00300 SRP54-type proteins GTP-binding domain signature. 862908012012 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012013 HMMPfam hit to PF02881, GTP-binding signal recognition particle SRP54, G-domain, score 5e-08 862908012014 1 probable transmembrane helix predicted for BMS3196 by TMHMM2.0 at aa 23-45 862908012015 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862908012016 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 862908012017 motif 1; other site 862908012018 dimer interface [polypeptide binding]; other site 862908012019 active site 862908012020 motif 2; other site 862908012021 motif 3; other site 862908012022 HMMPfam hit to PF00152, tRNA synthetase, class II (D, K and N), score 4.6e-17 862908012023 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908012024 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908012025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908012026 active site 862908012027 phosphorylation site [posttranslational modification] 862908012028 intermolecular recognition site; other site 862908012029 dimerization interface [polypeptide binding]; other site 862908012030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908012031 Walker A motif; other site 862908012032 ATP binding site [chemical binding]; other site 862908012033 Walker B motif; other site 862908012034 arginine finger; other site 862908012035 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 2.1e-103 862908012036 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 862908012037 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012038 HMMPfam hit to PF00072, Response regulator receiver, score 2.1e-17 862908012039 Putative Ig domain; Region: He_PIG; pfam05345 862908012040 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 862908012041 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862908012042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908012043 FeS/SAM binding site; other site 862908012044 TRAM domain; Region: TRAM; cl01282 862908012045 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 0.00052 862908012046 HMMPfam hit to PF04055, Radical SAM, score 1.3e-26 862908012047 PS01278 Uncharacterized protein family UPF0004 signature. 862908012048 HMMPfam hit to PF00919, Protein of unknown function UPF0004, score 6.9e-32 862908012049 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862908012050 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908012051 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908012052 catalytic residue [active] 862908012053 Signal peptide predicted for BMS3205 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.467 between residues 21 and 22 862908012054 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012055 HMMPfam hit to PF07719, , score 1.1; PF07719, Tetratricopeptide repeat 862908012056 HMMPfam hit to PF07719, , score 1.3; PF07719, Tetratricopeptide repeat 862908012057 HMMPfam hit to PF07719, , score 1.6; PF07719, Tetratricopeptide repeat 862908012058 HMMPfam hit to PF07719, , score 1.1; PF07719, Tetratricopeptide repeat 862908012059 HMMPfam hit to PF01464, SLT, score 8.3e-25 862908012060 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 862908012061 Signal peptide predicted for BMS3206 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.608 between residues 35 and 36 862908012062 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862908012063 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 862908012064 Walker A/P-loop; other site 862908012065 ATP binding site [chemical binding]; other site 862908012066 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 862908012067 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 862908012068 ABC transporter signature motif; other site 862908012069 Walker B; other site 862908012070 D-loop; other site 862908012071 H-loop/switch region; other site 862908012072 HMMPfam hit to PF02483, Structural maintenance of chromosome protein SMC, C-terminal, score 1.2e-80 862908012073 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.2e-65 862908012074 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012075 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012076 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862908012077 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862908012078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908012079 dimer interface [polypeptide binding]; other site 862908012080 putative CheW interface [polypeptide binding]; other site 862908012081 Signal peptide predicted for BMS3208 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.413 between residues 43 and 44 862908012082 2 probable transmembrane helices predicted for BMS3208 by TMHMM2.0 at aa 12-34 and 196-218 862908012083 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 1.5e-39 862908012084 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862908012085 HMMPfam hit to PF07719, , score 0.19; PF07719, Tetratricopeptide repeat 862908012086 Signal peptide predicted for BMS3209 by SignalP 2.0 HMM (Signal peptide probability 0.812) with cleavage site probability 0.801 between residues 27 and 28 862908012087 Signal peptide predicted for BMS3210 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 19 and 20 862908012088 hypothetical protein; Provisional; Region: PRK10318 862908012089 Signal peptide predicted for BMS3211 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.992 between residues 20 and 21 862908012090 PS00268 Cecropin family signature. 862908012091 Recombinase; Region: Recombinase; pfam07508 862908012092 1 probable transmembrane helix predicted for BMS3213 by TMHMM2.0 at aa 4-26 862908012093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862908012094 NAD(P) binding site [chemical binding]; other site 862908012095 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 862908012096 active site 862908012097 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012098 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 862908012099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862908012100 putative substrate translocation pore; other site 862908012101 12 probable transmembrane helices predicted for BMS3215 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 110-132, 139-161, 171-190, 211-233, 248-267, 274-296, 301-323, 336-358 and 363-385 862908012102 HMMPfam hit to PF07690, , score 4.4e-43 862908012103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862908012104 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 862908012105 1 probable transmembrane helix predicted for BMS3216 by TMHMM2.0 at aa 7-29 862908012106 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 862908012107 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 862908012108 Signal peptide predicted for BMS3217 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.500 between residues 25 and 26 862908012109 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012110 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 862908012111 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 862908012112 putative NAD(P) binding site [chemical binding]; other site 862908012113 putative substrate binding site [chemical binding]; other site 862908012114 catalytic Zn binding site [ion binding]; other site 862908012115 structural Zn binding site [ion binding]; other site 862908012116 dimer interface [polypeptide binding]; other site 862908012117 HMMPfam hit to PF00107, Zinc-containing alcohol dehydrogenase superfamily, score 1.7e-112 862908012118 PS00059 Zinc-containing alcohol dehydrogenases signature. 862908012119 PS00190 Cytochrome c family heme-binding site signature. 862908012120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862908012121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862908012122 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 862908012123 putative effector binding pocket; other site 862908012124 putative dimerization interface [polypeptide binding]; other site 862908012125 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.5e-16 862908012126 PS00044 Bacterial regulatory proteins, lysR family signature. 862908012127 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.1e-34 862908012128 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 862908012129 active site 862908012130 dimerization interface [polypeptide binding]; other site 862908012131 HMMPfam hit to PF01725, Ham1-like protein, score 1e-38 862908012132 ribonuclease PH; Reviewed; Region: rph; PRK00173 862908012133 Ribonuclease PH; Region: RNase_PH_bact; cd11362 862908012134 hexamer interface [polypeptide binding]; other site 862908012135 active site 862908012136 HMMPfam hit to PF03725, 3' exoribonuclease, score 1.4e-11 862908012137 HMMPfam hit to PF01138, 3' exoribonuclease, score 3.9e-40 862908012138 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 862908012139 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 862908012140 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 4.8e-11 862908012141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908012142 active site 862908012143 phosphorylation site [posttranslational modification] 862908012144 intermolecular recognition site; other site 862908012145 dimerization interface [polypeptide binding]; other site 862908012146 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862908012147 active site 862908012148 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908012149 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908012150 phosphopeptide binding site; other site 862908012151 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908012152 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908012153 phosphopeptide binding site; other site 862908012154 HMMPfam hit to PF07719, , score 1.5; PF07719, Tetratricopeptide repeat 862908012155 HMMPfam hit to PF07719, , score 2.2; PF07719, Tetratricopeptide repeat 862908012156 HMMPfam hit to PF00498, Forkhead-associated, score 1.8e-13 862908012157 HMMPfam hit to PF00498, Forkhead-associated, score 7.3e-10 862908012158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908012159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908012160 phosphopeptide binding site; other site 862908012161 HMMPfam hit to PF00498, Forkhead-associated, score 1.3e-12 862908012162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908012163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908012164 phosphopeptide binding site; other site 862908012165 2 probable transmembrane helices predicted for BMS3227 by TMHMM2.0 at aa 155-177 and 321-343 862908012166 HMMPfam hit to PF00498, Forkhead-associated, score 4.7e-11 862908012167 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 862908012168 HMMPfam hit to PF02643, Protein of unknown function DUF192, score 1.2e-27 862908012169 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 862908012170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 862908012171 5 probable transmembrane helices predicted for BMS3229 by TMHMM2.0 at aa 5-27, 105-127, 201-223, 227-246 and 375-397 862908012172 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 9.1e-14 862908012173 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 862908012174 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 862908012175 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 1.6e-40 862908012176 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862908012177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908012178 dimer interface [polypeptide binding]; other site 862908012179 conserved gate region; other site 862908012180 ABC-ATPase subunit interface; other site 862908012181 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.3e-36 862908012182 6 probable transmembrane helices predicted for BMS3231 by TMHMM2.0 at aa 11-33, 82-104, 116-138, 142-159, 190-212 and 243-265 862908012183 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 862908012184 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862908012185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862908012186 dimer interface [polypeptide binding]; other site 862908012187 conserved gate region; other site 862908012188 putative PBP binding loops; other site 862908012189 ABC-ATPase subunit interface; other site 862908012190 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.6e-43 862908012191 6 probable transmembrane helices predicted for BMS3232 by TMHMM2.0 at aa 7-29, 99-121, 134-156, 171-188, 229-251 and 271-290 862908012192 Signal peptide predicted for BMS3233 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.285 between residues 20 and 21 862908012193 PS00037 Myb DNA-binding domain repeat signature 1. 862908012194 rod shape-determining protein MreB; Provisional; Region: PRK13927 862908012195 MreB and similar proteins; Region: MreB_like; cd10225 862908012196 nucleotide binding site [chemical binding]; other site 862908012197 Mg binding site [ion binding]; other site 862908012198 putative protofilament interaction site [polypeptide binding]; other site 862908012199 RodZ interaction site [polypeptide binding]; other site 862908012200 HMMPfam hit to PF06723, Cell shape determining protein MreB/Mrl, score 1e-221 862908012201 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862908012202 HMMPfam hit to PF01048, Purine and other phosphorylases, family 1, score 1.7e-11 862908012203 Signal peptide predicted for BMS3236 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.669 between residues 53 and 54 862908012204 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; cl17501 862908012205 1 probable transmembrane helix predicted for BMS3238 by TMHMM2.0 at aa 276-298 862908012206 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862908012207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908012208 active site 862908012209 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 3e-12 862908012210 3 probable transmembrane helices predicted for BMS3239 by TMHMM2.0 at aa 233-255, 259-281 and 290-312 862908012211 TPR repeat; Region: TPR_11; pfam13414 862908012212 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862908012213 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862908012214 Signal peptide predicted for BMS3240 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.436 between residues 25 and 26 862908012215 Signal peptide predicted for BMS3241 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.409 between residues 16 and 17 862908012216 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908012217 chaperone protein DnaJ; Provisional; Region: PRK10767 862908012218 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862908012219 HSP70 interaction site [polypeptide binding]; other site 862908012220 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 862908012221 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 862908012222 Zn binding sites [ion binding]; other site 862908012223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862908012224 dimer interface [polypeptide binding]; other site 862908012225 HMMPfam hit to PF01556, Chaperone DnaJ, C-terminal, score 3e-72 862908012226 HMMPfam hit to PF00684, DnaJ central region, score 5.2e-34 862908012227 PS00190 Cytochrome c family heme-binding site signature. 862908012228 PS00637 CXXCXGXG dnaJ domain signature. 862908012229 PS00190 Cytochrome c family heme-binding site signature. 862908012230 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 2.2e-36 862908012231 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 862908012232 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 862908012233 nucleotide binding site [chemical binding]; other site 862908012234 NEF interaction site [polypeptide binding]; other site 862908012235 SBD interface [polypeptide binding]; other site 862908012236 HMMPfam hit to PF00012, Heat shock protein Hsp70, score 0 862908012237 PS01036 Heat shock hsp70 proteins family signature 3. 862908012238 PS00329 Heat shock hsp70 proteins family signature 2. 862908012239 PS00297 Heat shock hsp70 proteins family signature 1. 862908012240 GrpE; Region: GrpE; pfam01025 862908012241 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 862908012242 dimer interface [polypeptide binding]; other site 862908012243 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 862908012244 HMMPfam hit to PF01025, GrpE protein, score 1.3e-56 862908012245 PS01071 grpE protein signature. 862908012246 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 862908012247 Signal peptide predicted for BMS3245 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.772 between residues 19 and 20 862908012248 1 probable transmembrane helix predicted for BMS3245 by TMHMM2.0 at aa 7-24 862908012249 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 862908012250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862908012251 FeS/SAM binding site; other site 862908012252 HMMPfam hit to PF06969, HemN, C-terminal, score 0.0037 862908012253 HMMPfam hit to PF04055, Radical SAM, score 4.7e-22 862908012254 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862908012255 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862908012256 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862908012257 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862908012258 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862908012259 HMMPfam hit to PF00675, Insulinase-like, score 1.5e-31 862908012260 PS00143 Insulinase family, zinc-binding region signature. 862908012261 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.4e-22 862908012262 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.3e-25 862908012263 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 862908012264 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 862908012265 active site 862908012266 substrate binding site [chemical binding]; other site 862908012267 coenzyme B12 binding site [chemical binding]; other site 862908012268 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 862908012269 B12 binding site [chemical binding]; other site 862908012270 cobalt ligand [ion binding]; other site 862908012271 HMMPfam hit to PF01642, Methylmalonyl-CoA mutase, score 0 862908012272 PS00544 Methylmalonyl-CoA mutase signature. 862908012273 HMMPfam hit to PF02310, Coenzyme B12-binding, score 9.3e-25 862908012274 membrane ATPase/protein kinase; Provisional; Region: PRK09435 862908012275 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 862908012276 Walker A; other site 862908012277 HMMPfam hit to PF03308, ArgK protein, score 4.4e-136 862908012278 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012279 Signal peptide predicted for BMS3251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 862908012280 1 probable transmembrane helix predicted for BMS3252 by TMHMM2.0 at aa 40-62 862908012281 PS01036 Heat shock hsp70 proteins family signature 3. 862908012282 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 862908012283 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 862908012284 3 probable transmembrane helices predicted for BMS3253 by TMHMM2.0 at aa 626-643, 648-665 and 685-707 862908012285 HMMPfam hit to PF02543, Carbamoyltransferase, score 2.9e-137 862908012286 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012287 Radical SAM superfamily; Region: Radical_SAM; pfam04055 862908012288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 862908012289 FeS/SAM binding site; other site 862908012290 HMMPfam hit to PF04055, Radical SAM, score 0.0044 862908012291 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 862908012292 catalytic triad [active] 862908012293 1 probable transmembrane helix predicted for BMS3255 by TMHMM2.0 at aa 9-31 862908012294 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 1.4e-05 862908012295 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 862908012296 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 862908012297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908012298 catalytic residue [active] 862908012299 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.3e-08 862908012300 PS00245 Phytochrome chromophore attachment site signature. 862908012301 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862908012302 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: COG2117 862908012303 Ligand Binding Site [chemical binding]; other site 862908012304 PS00697 ATP-dependent DNA ligase AMP-binding site. 862908012305 Signal peptide predicted for BMS3260 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.890 between residues 18 and 19 862908012306 Signal peptide predicted for BMS3261 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.850 between residues 28 and 29 862908012307 1 probable transmembrane helix predicted for BMS3261 by TMHMM2.0 at aa 9-26 862908012308 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862908012310 HMMPfam hit to PF00753, Beta-lactamase-like, score 3.1e-15 862908012311 Signal peptide predicted for BMS3262 by SignalP 2.0 HMM (Signal peptide probability 0.868) with cleavage site probability 0.855 between residues 16 and 17 862908012312 Predicted transcriptional regulators [Transcription]; Region: COG1733 862908012313 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 862908012314 HMMPfam hit to PF01638, Protein of unknown function DUF24, score 4.9e-14 862908012315 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 862908012316 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 6e-10 862908012317 HflC protein; Region: hflC; TIGR01932 862908012318 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 862908012319 HMMPfam hit to PF01145, Band 7 protein, score 6e-31 862908012320 Signal peptide predicted for BMS3266 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 20 and 21 862908012321 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 862908012322 HflK protein; Region: hflK; TIGR01933 862908012323 HMMPfam hit to PF01145, Band 7 protein, score 1.1e-35 862908012324 1 probable transmembrane helix predicted for BMS3267 by TMHMM2.0 at aa 29-51 862908012325 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862908012326 carboxyltransferase (CT) interaction site; other site 862908012327 biotinylation site [posttranslational modification]; other site 862908012328 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 5e-21 862908012329 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862908012330 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862908012331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862908012332 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 862908012333 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 2.8e-32 862908012334 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.3e-95 862908012335 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 862908012336 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 6.9e-31 862908012337 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 862908012338 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 862908012339 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 862908012340 HMMPfam hit to PF01039, Carboxyl transferase, score 4.1e-269 862908012341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908012342 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 862908012343 Walker A motif; other site 862908012344 ATP binding site [chemical binding]; other site 862908012345 Walker B motif; other site 862908012346 arginine finger; other site 862908012347 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862908012348 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.1e-10 862908012349 PS00688 Sigma-54 interaction domain C-terminal part signature. 862908012350 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 1.9e-139 862908012351 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 862908012352 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 862908012353 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 862908012354 catalytic residues [active] 862908012355 PS00194 Thioredoxin family active site. 862908012356 1 probable transmembrane helix predicted for BMS3272 by TMHMM2.0 at aa 7-24 862908012357 Signal peptide predicted for BMS3272 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.505 between residues 19 and 20 862908012358 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 862908012359 HMMPfam hit to PF01196, Ribosomal protein L17, score 5.7e-50 862908012360 PS01167 Ribosomal protein L17 signature. 862908012361 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 862908012362 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 862908012363 alphaNTD - beta interaction site [polypeptide binding]; other site 862908012364 alphaNTD homodimer interface [polypeptide binding]; other site 862908012365 alphaNTD - beta' interaction site [polypeptide binding]; other site 862908012366 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 862908012367 HMMPfam hit to PF03118, RNA polymerase, alpha subunit, C-terminal, score 2.8e-24 862908012368 HMMPfam hit to PF01193, RNA polymerase, dimerisation, score 4.5e-17 862908012369 HMMPfam hit to PF01000, RNA polymerase, insert, score 4.1e-43 862908012370 30S ribosomal protein S11; Validated; Region: PRK05309 862908012371 HMMPfam hit to PF00411, Ribosomal protein S11, score 1.2e-57 862908012372 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 862908012373 30S ribosomal protein S13; Region: bact_S13; TIGR03631 862908012374 HMMPfam hit to PF00416, Ribosomal protein S13, score 1.1e-48 862908012375 PS00646 Ribosomal protein S13 signature. 862908012376 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 862908012377 HMMPfam hit to PF00444, Ribosomal protein L36, score 3e-14 862908012378 PS00828 Ribosomal protein L36 signature. 862908012379 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 862908012380 rRNA binding site [nucleotide binding]; other site 862908012381 predicted 30S ribosome binding site; other site 862908012382 HMMPfam hit to PF00575, RNA binding S1, score 9.2e-08 862908012383 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 862908012384 adenylate kinase; Reviewed; Region: adk; PRK00279 862908012385 AMP-binding site [chemical binding]; other site 862908012386 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 862908012387 HMMPfam hit to PF00406, Adenylate kinase, score 4.2e-63 862908012388 HMMPfam hit to PF05191, Adenylate kinase, lid region, score 3e-16 862908012389 PS00113 Adenylate kinase signature. 862908012390 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 862908012391 SecY translocase; Region: SecY; pfam00344 862908012392 10 probable transmembrane helices predicted for BMS3280 by TMHMM2.0 at aa 20-42, 69-91, 111-133, 148-167, 174-193, 208-230, 264-286, 306-328, 362-384 and 394-416 862908012393 HMMPfam hit to PF00344, SecY protein, score 5.4e-105 862908012394 Signal peptide predicted for BMS3280 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.778 between residues 28 and 29 862908012395 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 862908012396 HMMPfam hit to PF00256, Ribosomal protein L15, score 2.4e-09 862908012397 HMMPfam hit to PF01305, Ribosomal protein L15, score 8e-42 862908012398 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 862908012399 23S rRNA binding site [nucleotide binding]; other site 862908012400 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 862908012401 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 862908012402 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 862908012403 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal, score 6.9e-30 862908012404 HMMPfam hit to PF00333, Ribosomal protein S5, score 2.2e-37 862908012405 PS00585 Ribosomal protein S5 signature. 862908012406 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 862908012407 23S rRNA interface [nucleotide binding]; other site 862908012408 L21e interface [polypeptide binding]; other site 862908012409 5S rRNA interface [nucleotide binding]; other site 862908012410 L27 interface [polypeptide binding]; other site 862908012411 L5 interface [polypeptide binding]; other site 862908012412 HMMPfam hit to PF00861, Ribosomal protein L18P/L5E, score 1.3e-38 862908012413 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 862908012414 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862908012415 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862908012416 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.2e-24 862908012417 PS00525 Ribosomal protein L6 signature 1. 862908012418 HMMPfam hit to PF00347, Ribosomal protein L6, score 8.5e-25 862908012419 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 862908012420 HMMPfam hit to PF00410, Ribosomal protein S8, score 1e-48 862908012421 PS00053 Ribosomal protein S8 signature. 862908012422 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 862908012423 HMMPfam hit to PF00253, Ribosomal protein S14, score 8.7e-26 862908012424 PS00527 Ribosomal protein S14 signature. 862908012425 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 862908012426 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 862908012427 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 862908012428 HMMPfam hit to PF00673, Ribosomal protein L5, score 4.1e-48 862908012429 HMMPfam hit to PF00281, Ribosomal protein L5, score 4.2e-23 862908012430 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 862908012431 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 862908012432 RNA binding site [nucleotide binding]; other site 862908012433 HMMPfam hit to PF00467, KOW, score 2.7e-09 862908012434 PS01108 Ribosomal protein L24 signature. 862908012435 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012436 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 862908012437 HMMPfam hit to PF00238, Ribosomal protein L14b/L23e, score 1.1e-69 862908012438 PS00049 Ribosomal protein L14 signature. 862908012439 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 862908012440 HMMPfam hit to PF00366, Ribosomal protein S17, score 4e-28 862908012441 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 862908012442 23S rRNA interface [nucleotide binding]; other site 862908012443 putative translocon interaction site; other site 862908012444 signal recognition particle (SRP54) interaction site; other site 862908012445 L23 interface [polypeptide binding]; other site 862908012446 trigger factor interaction site; other site 862908012447 HMMPfam hit to PF00831, Ribosomal protein L29, score 3.3e-16 862908012448 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 862908012449 23S rRNA interface [nucleotide binding]; other site 862908012450 5S rRNA interface [nucleotide binding]; other site 862908012451 putative antibiotic binding site [chemical binding]; other site 862908012452 L25 interface [polypeptide binding]; other site 862908012453 L27 interface [polypeptide binding]; other site 862908012454 HMMPfam hit to PF00252, Ribosomal protein L16, score 2.3e-80 862908012455 PS00701 Ribosomal protein L16 signature 2. 862908012456 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 862908012457 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 862908012458 G-X-X-G motif; other site 862908012459 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 862908012460 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal, score 2.1e-47 862908012461 HMMPfam hit to PF07650, KH, type 2, score 3e-19 862908012462 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal, score 2.6e-24 862908012463 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 862908012464 protein-rRNA interface [nucleotide binding]; other site 862908012465 putative translocon binding site; other site 862908012466 HMMPfam hit to PF00237, Ribosomal protein L22/L17, score 4.1e-28 862908012467 PS00464 Ribosomal protein L22 signature. 862908012468 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 862908012469 HMMPfam hit to PF00203, Ribosomal protein S19/S15, score 3.3e-47 862908012470 PS00323 Ribosomal protein S19 signature. 862908012471 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 862908012472 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 862908012473 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 862908012474 HMMPfam hit to PF03947, Ribosomal protein L2, score 1.9e-85 862908012475 PS00467 Ribosomal protein L2 signature. 862908012476 HMMPfam hit to PF00181, Ribosomal protein L2, score 1.6e-45 862908012477 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 862908012478 HMMPfam hit to PF00276, Ribosomal L23 protein, score 6.1e-27 862908012479 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 862908012480 HMMPfam hit to PF00573, Ribosomal protein L4/L1e, score 5.8e-41 862908012481 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 862908012482 HMMPfam hit to PF00297, Ribosomal protein L3, score 1.1e-70 862908012483 PS00474 Ribosomal protein L3 signature. 862908012484 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 862908012485 HMMPfam hit to PF00338, Ribosomal protein S10, score 2e-57 862908012486 PS00361 Ribosomal protein S10 signature. 862908012487 elongation factor Tu; Reviewed; Region: PRK00049 862908012488 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862908012489 G1 box; other site 862908012490 GEF interaction site [polypeptide binding]; other site 862908012491 GTP/Mg2+ binding site [chemical binding]; other site 862908012492 Switch I region; other site 862908012493 G2 box; other site 862908012494 G3 box; other site 862908012495 Switch II region; other site 862908012496 G4 box; other site 862908012497 G5 box; other site 862908012498 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862908012499 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862908012500 Antibiotic Binding Site [chemical binding]; other site 862908012501 HMMPfam hit to PF03143, Elongation factor Tu, C-terminal, score 5.4e-56 862908012502 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 1.6e-23 862908012503 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 9e-96 862908012504 PS00301 GTP-binding elongation factors signature. 862908012505 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012506 elongation factor G; Reviewed; Region: PRK00007 862908012507 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862908012508 G1 box; other site 862908012509 putative GEF interaction site [polypeptide binding]; other site 862908012510 GTP/Mg2+ binding site [chemical binding]; other site 862908012511 Switch I region; other site 862908012512 G2 box; other site 862908012513 G3 box; other site 862908012514 Switch II region; other site 862908012515 G4 box; other site 862908012516 G5 box; other site 862908012517 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862908012518 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 862908012519 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862908012520 HMMPfam hit to PF00679, Elongation factor G, C-terminal, score 7.3e-35 862908012521 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 3.2e-28 862908012522 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 6.5e-18 862908012523 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.5e-113 862908012524 PS00301 GTP-binding elongation factors signature. 862908012525 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012526 30S ribosomal protein S7; Validated; Region: PRK05302 862908012527 HMMPfam hit to PF00177, Ribosomal protein S7, score 8.4e-84 862908012528 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 862908012529 S17 interaction site [polypeptide binding]; other site 862908012530 S8 interaction site; other site 862908012531 16S rRNA interaction site [nucleotide binding]; other site 862908012532 streptomycin interaction site [chemical binding]; other site 862908012533 23S rRNA interaction site [nucleotide binding]; other site 862908012534 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 862908012535 HMMPfam hit to PF00164, Ribosomal protein S12/S23, score 1.1e-71 862908012536 PS00055 Ribosomal protein S12 signature. 862908012537 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 862908012538 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 862908012539 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 862908012540 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 862908012541 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 862908012542 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862908012543 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 862908012544 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862908012545 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 862908012546 DNA binding site [nucleotide binding] 862908012547 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 862908012548 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain 5, score 2.2e-68 862908012549 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain 4, score 1.7e-26 862908012550 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain 3, score 2.3e-37 862908012551 HMMPfam hit to PF00623, RNA polymerase, alpha subunit, score 2.4e-81 862908012552 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain 1, score 3.1e-133 862908012553 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 862908012554 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 862908012555 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 862908012556 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862908012557 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 862908012558 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862908012559 RPB10 interaction site [polypeptide binding]; other site 862908012560 RPB3 interaction site [polypeptide binding]; other site 862908012561 RPB11 interaction site [polypeptide binding]; other site 862908012562 RPB12 interaction site [polypeptide binding]; other site 862908012563 RPB1 interaction site [polypeptide binding]; other site 862908012564 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain 7, score 8.2e-48 862908012565 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain 6, score 6.5e-179 862908012566 PS01166 RNA polymerases beta chain signature. 862908012567 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain 3, score 2e-44 862908012568 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 4.8e-08 862908012569 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 9.7e-09 862908012570 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 862908012571 core dimer interface [polypeptide binding]; other site 862908012572 peripheral dimer interface [polypeptide binding]; other site 862908012573 L10 interface [polypeptide binding]; other site 862908012574 L11 interface [polypeptide binding]; other site 862908012575 putative EF-Tu interaction site [polypeptide binding]; other site 862908012576 putative EF-G interaction site [polypeptide binding]; other site 862908012577 HMMPfam hit to PF00542, Ribosomal protein L7/L12, score 6.6e-38 862908012578 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 862908012579 23S rRNA interface [nucleotide binding]; other site 862908012580 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 862908012581 HMMPfam hit to PF00466, Ribosomal protein L10, score 4.8e-12 862908012582 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 862908012583 mRNA/rRNA interface [nucleotide binding]; other site 862908012584 HMMPfam hit to PF00687, Ribosomal protein L1, score 4.6e-122 862908012585 PS01199 Ribosomal protein L1 signature. 862908012586 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 862908012587 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 862908012588 23S rRNA interface [nucleotide binding]; other site 862908012589 L7/L12 interface [polypeptide binding]; other site 862908012590 putative thiostrepton binding site; other site 862908012591 L25 interface [polypeptide binding]; other site 862908012592 HMMPfam hit to PF00298, Ribosomal protein L11, score 2e-14 862908012593 HMMPfam hit to PF03946, Ribosomal protein L11, score 6.8e-34 862908012594 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 862908012595 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 862908012596 putative homodimer interface [polypeptide binding]; other site 862908012597 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 862908012598 heterodimer interface [polypeptide binding]; other site 862908012599 homodimer interface [polypeptide binding]; other site 862908012600 PS01014 Transcription termination factor nusG signature. 862908012601 HMMPfam hit to PF00467, KOW, score 4.5e-06 862908012602 HMMPfam hit to PF02357, Bacterial transcription antitermination protein NusG, score 2.6e-10 862908012603 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 862908012604 HMMPfam hit to PF00584, Protein secE/sec61-gamma protein, score 1e-06 862908012605 3 probable transmembrane helices predicted for BMS3317 by TMHMM2.0 at aa 12-34, 49-68 and 98-120 862908012606 elongation factor Tu; Reviewed; Region: PRK00049 862908012607 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862908012608 G1 box; other site 862908012609 GEF interaction site [polypeptide binding]; other site 862908012610 GTP/Mg2+ binding site [chemical binding]; other site 862908012611 Switch I region; other site 862908012612 G2 box; other site 862908012613 G3 box; other site 862908012614 Switch II region; other site 862908012615 G4 box; other site 862908012616 G5 box; other site 862908012617 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862908012618 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862908012619 Antibiotic Binding Site [chemical binding]; other site 862908012620 HMMPfam hit to PF03143, Elongation factor Tu, C-terminal, score 5.4e-56 862908012621 HMMPfam hit to PF03144, Elongation factor Tu, domain 2, score 1.6e-23 862908012622 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 9e-96 862908012623 PS00301 GTP-binding elongation factors signature. 862908012624 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012625 Signal peptide predicted for BMS3319 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.509 between residues 16 and 17 862908012626 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 862908012627 Signal peptide predicted for BMS3321 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 20 and 21 862908012628 Signal peptide predicted for BMS3322 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.961 between residues 28 and 29 862908012629 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862908012630 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862908012631 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase (SpoU), score 6e-20 862908012632 prolyl-tRNA synthetase; Provisional; Region: PRK09194 862908012633 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 862908012634 dimer interface [polypeptide binding]; other site 862908012635 motif 1; other site 862908012636 active site 862908012637 motif 2; other site 862908012638 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 862908012639 putative deacylase active site [active] 862908012640 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862908012641 active site 862908012642 motif 3; other site 862908012643 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 862908012644 anticodon binding site; other site 862908012645 HMMPfam hit to PF03129, Anticodon-binding, score 1.5e-22 862908012646 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 2.4e-05 862908012647 HMMPfam hit to PF00587, tRNA synthetases, class-II (G, H, P and S), score 8.2e-57 862908012648 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 862908012649 Signal peptide predicted for BMS3325 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.640 between residues 30 and 31 862908012650 1 probable transmembrane helix predicted for BMS3326 by TMHMM2.0 at aa 7-26 862908012651 7 probable transmembrane helices predicted for BMS3327 by TMHMM2.0 at aa 12-34, 49-71, 83-105, 120-142, 206-223, 233-255 and 275-294 862908012652 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862908012653 metal ion-dependent adhesion site (MIDAS); other site 862908012654 Signal peptide predicted for BMS3328 by SignalP 2.0 HMM (Signal peptide probability 0.836) with cleavage site probability 0.265 between residues 18 and 19 862908012655 Signal peptide predicted for BMS3329 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.691 between residues 21 and 22 862908012656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012657 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862908012658 dimer interface [polypeptide binding]; other site 862908012659 putative CheW interface [polypeptide binding]; other site 862908012660 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.5e-09 862908012661 4 probable transmembrane helices predicted for BMS3330 by TMHMM2.0 at aa 20-42, 62-84, 97-119 and 139-161 862908012662 1 probable transmembrane helix predicted for BMS3331 by TMHMM2.0 at aa 7-29 862908012663 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 862908012664 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 862908012665 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 862908012666 Peptidase family M28; Region: Peptidase_M28; pfam04389 862908012667 metal binding site [ion binding]; metal-binding site 862908012668 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862908012669 HMMPfam hit to PF04389, Peptidase M28, score 3.4e-46 862908012670 Signal peptide predicted for BMS3332 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.871 between residues 19 and 20 862908012671 4 probable transmembrane helices predicted for BMS3333 by TMHMM2.0 at aa 10-32, 49-68, 88-105 and 118-140 862908012672 5 probable transmembrane helices predicted for BMS3334 by TMHMM2.0 at aa 7-26, 145-167, 180-202, 217-233 and 240-257 862908012673 Protein of unknown function, DUF399; Region: DUF399; cl01139 862908012674 Signal peptide predicted for BMS3335 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.993 between residues 16 and 17 862908012675 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862908012676 CoenzymeA binding site [chemical binding]; other site 862908012677 subunit interaction site [polypeptide binding]; other site 862908012678 PHB binding site; other site 862908012679 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.2e-14 862908012680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012681 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 862908012682 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 862908012683 HMMPfam hit to PF03331, UDP-3-0-acyl N-acetylglucosamine deacetylase, score 1.2e-122 862908012684 Signal peptide predicted for BMS3338 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.569 between residues 18 and 19 862908012685 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 862908012686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908012687 Walker A motif; other site 862908012688 ATP binding site [chemical binding]; other site 862908012689 Walker B motif; other site 862908012690 arginine finger; other site 862908012691 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 862908012692 HMMPfam hit to PF05491, Holliday junction DNA helicase RuvB, C-terminal, score 3.5e-39 862908012693 HMMPfam hit to PF00004, AAA ATPase, central region, score 1e-31 862908012694 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012695 HMMPfam hit to PF05496, Holliday junction DNA helicase RuvB, N-terminal, score 1.2e-09 862908012696 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 862908012697 RuvA N terminal domain; Region: RuvA_N; pfam01330 862908012698 HMMPfam hit to PF01330, Bacterial DNA recombination protein, RuvA, score 4.6e-09 862908012699 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 862908012700 active site 862908012701 putative DNA-binding cleft [nucleotide binding]; other site 862908012702 dimer interface [polypeptide binding]; other site 862908012703 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease RuvC, score 3e-39 862908012704 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 862908012705 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 862908012706 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 862908012707 homodimer interface [polypeptide binding]; other site 862908012708 NADP binding site [chemical binding]; other site 862908012709 substrate binding site [chemical binding]; other site 862908012710 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 3.5e-19 862908012711 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 2.8e-73 862908012712 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 862908012713 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 862908012714 HMMPfam hit to PF01571, Glycine cleavage T protein (aminomethyl transferase), score 1.2e-82 862908012715 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 862908012716 lipoyl attachment site [posttranslational modification]; other site 862908012717 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 1.7e-65 862908012718 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 862908012719 TonB C terminal; Region: TonB_2; pfam13103 862908012720 1 probable transmembrane helix predicted for BMS3347 by TMHMM2.0 at aa 17-36 862908012721 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 862908012722 Transglycosylase; Region: Transgly; pfam00912 862908012723 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 862908012724 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 2.6e-30 862908012725 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 3.3e-72 862908012726 1 probable transmembrane helix predicted for BMS3348 by TMHMM2.0 at aa 7-29 862908012727 Signal peptide predicted for BMS3348 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.452 between residues 24 and 25 862908012728 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 862908012729 active site 862908012730 nucleophile elbow; other site 862908012731 Signal peptide predicted for BMS3349 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.385 between residues 19 and 20 862908012732 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 862908012733 HMMPfam hit to PF02609, Exonuclease VII, small subunit, score 2.2e-19 862908012734 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 862908012735 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862908012736 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 862908012737 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 3.9e-13 862908012738 PS00588 Flagella basal body rod proteins signature. 862908012739 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 0.00022 862908012740 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 862908012741 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862908012742 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862908012743 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862908012744 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.3e-11 862908012745 PS00588 Flagella basal body rod proteins signature. 862908012746 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 1.9e-18 862908012747 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 862908012748 Flagellar L-ring protein; Region: FlgH; cl17277 862908012749 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 862908012750 Flagellar P-ring protein; Region: FlgI; pfam02119 862908012751 Signal peptide predicted for BMS3355 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.982 between residues 18 and 19 862908012752 HMMPfam hit to PF02119, Flagellar P-ring protein, score 1.3e-111 862908012753 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 862908012754 FlgN protein; Region: FlgN; pfam05130 862908012755 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 862908012756 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862908012757 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 2.7e-06 862908012758 HMMPfam hit to PF06429, Protein of unknown function DUF1078, score 3.4e-18 862908012759 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862908012760 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 862908012761 HMMPfam hit to PF00669, Flagellin, N-terminal, score 0.00021 862908012762 carbon storage regulator; Provisional; Region: PRK01712 862908012763 HMMPfam hit to PF02599, Carbon storage regulator, score 1.1e-29 862908012764 FliW protein; Region: FliW; cl00740 862908012765 HMMPfam hit to PF02623, Protein of unknown function DUF180, score 4.8e-16 862908012766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908012767 binding surface 862908012768 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862908012769 TPR motif; other site 862908012770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908012771 binding surface 862908012772 TPR motif; other site 862908012773 HMMPfam hit to PF00515, TPR repeat, score 0.51; HMMPfam hit to PF07719, , score 0.66; PF07719, Tetratricopeptide repeat 862908012774 HMMPfam hit to PF07719, , score 1.6; PF07719, Tetratricopeptide repeat 862908012775 HMMPfam hit to PF07719, , score 0.011; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.12 862908012776 HMMPfam hit to PF00515, TPR repeat, score 5.8e-07; HMMPfam hit to PF07719, , score 9e-06; PF07719, Tetratricopeptide repeat 862908012777 HMMPfam hit to PF07719, , score 0.042; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.12 862908012778 Tetratricopeptide repeat; Region: TPR_18; pfam13512 862908012779 Signal peptide predicted for BMS3364 by SignalP 2.0 HMM (Signal peptide probability 0.632) with cleavage site probability 0.242 between residues 23 and 24 862908012780 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012781 Domain of unknown function DUF20; Region: UPF0118; pfam01594 862908012782 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862908012783 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 7e-41 862908012784 8 probable transmembrane helices predicted for BMS3365 by TMHMM2.0 at aa 13-32, 37-59, 66-88, 150-169, 205-227, 237-259, 272-294 and 309-331 862908012785 Signal peptide predicted for BMS3365 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.663 between residues 40 and 41 862908012786 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862908012787 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862908012788 ligand binding site [chemical binding]; other site 862908012789 flexible hinge region; other site 862908012790 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 4.4e-21 862908012791 Bacterial SH3 domain homologues; Region: SH3b; smart00287 862908012792 2 probable transmembrane helices predicted for BMS3367 by TMHMM2.0 at aa 110-132 and 139-161 862908012793 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 862908012794 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862908012795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862908012796 catalytic residue [active] 862908012797 HMMPfam hit to PF00202, Aminotransferase class-III, score 5e-31 862908012798 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 862908012799 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 3.6e-39 862908012800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862908012801 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862908012802 NAD(P) binding site [chemical binding]; other site 862908012803 catalytic residues [active] 862908012804 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 8.8e-99 862908012805 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012806 PS00687 Aldehyde dehydrogenases glutamic acid active site. 862908012807 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 862908012808 Signal peptide predicted for BMS3371 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 16 and 17 862908012809 Signal peptide predicted for BMS3372 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.893 between residues 16 and 17 862908012810 HEXXH motif domain; Region: mod_HExxH; TIGR04267 862908012811 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 862908012812 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 862908012813 TPR repeat; Region: TPR_11; pfam13414 862908012814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908012815 binding surface 862908012816 TPR motif; other site 862908012817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862908012818 TPR motif; other site 862908012819 binding surface 862908012820 TPR repeat; Region: TPR_11; pfam13414 862908012821 HMMPfam hit to PF07719, , score 0.12; PF07719, Tetratricopeptide repeat; HMMPfam hit to PF00515, TPR repeat, score 0.052 862908012822 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012823 HMMPfam hit to PF00515, TPR repeat, score 0.035; HMMPfam hit to PF07719, , score 0.082; PF07719, Tetratricopeptide repeat 862908012824 HMMPfam hit to PF07719, , score 0.55; PF07719, Tetratricopeptide repeat 862908012825 HMMPfam hit to PF07719, , score 0.073; PF07719, Tetratricopeptide repeat 862908012826 HMMPfam hit to PF01571, Glycine cleavage T protein (aminomethyl transferase), score 0.002 862908012827 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 862908012828 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 8.3e-39 862908012829 PS01152 Hypothetical hesB/yadR/yfhF family signature. 862908012830 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862908012831 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862908012832 phosphopeptide binding site; other site 862908012833 HMMPfam hit to PF00498, Forkhead-associated, score 9.3e-09 862908012834 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 862908012835 HMMPfam hit to PF01923, Protein of unknown function DUF80, score 5e-64 862908012836 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012837 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 862908012838 B12 binding site [chemical binding]; other site 862908012839 cobalt ligand [ion binding]; other site 862908012840 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862908012841 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 862908012842 HMMPfam hit to PF01642, Methylmalonyl-CoA mutase, score 2.6e-57 862908012843 HMMPfam hit to PF03308, ArgK protein, score 1.4e-10 862908012844 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012845 HMMPfam hit to PF02310, Coenzyme B12-binding, score 3e-22 862908012846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862908012847 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862908012848 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 0.0001 862908012849 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908012850 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulfur binding, score 1.7e-05 862908012851 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 862908012852 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 862908012853 lipoprotein signal peptidase; Provisional; Region: PRK14787 862908012854 HMMPfam hit to PF01252, Peptidase A8, signal peptidase II, score 6.6e-37 862908012855 4 probable transmembrane helices predicted for BMS3381 by TMHMM2.0 at aa 31-48, 63-85, 92-111 and 131-153 862908012856 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862908012857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862908012858 active site 862908012859 phosphorylation site [posttranslational modification] 862908012860 intermolecular recognition site; other site 862908012861 dimerization interface [polypeptide binding]; other site 862908012862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862908012863 Walker A motif; other site 862908012864 ATP binding site [chemical binding]; other site 862908012865 Walker B motif; other site 862908012866 arginine finger; other site 862908012867 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 862908012868 PS00688 Sigma-54 interaction domain C-terminal part signature. 862908012869 HMMPfam hit to PF00158, Sigma-54 factor, interaction region, score 1.3e-135 862908012870 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 862908012871 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 862908012872 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-41 862908012873 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 862908012874 CHASE2 domain; Region: CHASE2; pfam05226 862908012875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862908012876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862908012877 dimer interface [polypeptide binding]; other site 862908012878 phosphorylation site [posttranslational modification] 862908012879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862908012880 ATP binding site [chemical binding]; other site 862908012881 Mg2+ binding site [ion binding]; other site 862908012882 G-X-G motif; other site 862908012883 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 8.2e-43 862908012884 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 9.8e-09 862908012885 4 probable transmembrane helices predicted for BMS3383 by TMHMM2.0 at aa 19-38, 314-331, 338-357 and 361-383 862908012886 HMMPfam hit to PF05226, CHASE2, score 0.00098 862908012887 4 probable transmembrane helices predicted for BMS3384 by TMHMM2.0 at aa 2-24, 28-50, 138-157 and 162-184 862908012888 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 862908012889 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 862908012890 AP (apurinic/apyrimidinic) site pocket; other site 862908012891 DNA interaction; other site 862908012892 Metal-binding active site; metal-binding site 862908012893 HMMPfam hit to PF01261, AP endonuclease, family 2, score 2.1e-18 862908012894 PS00094 C-5 cytosine-specific DNA methylases active site. 862908012895 Signal peptide predicted for BMS3387 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.416 between residues 18 and 19 862908012896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012897 4 probable transmembrane helices predicted for BMS3388 by TMHMM2.0 at aa 7-29, 44-66, 71-93 and 97-119 862908012898 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862908012899 active site 862908012900 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1e-05 862908012901 Phosphotransferase enzyme family; Region: APH; pfam01636 862908012902 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862908012903 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 862908012904 substrate binding site [chemical binding]; other site 862908012905 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 3.5e-18 862908012906 Signal peptide predicted for BMS3391 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.838 between residues 20 and 21 862908012907 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862908012909 Signal peptide predicted for BMS3392 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.436 between residues 25 and 26 862908012910 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012911 Signal peptide predicted for BMS3393 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.794 between residues 20 and 21 862908012912 Signal peptide predicted for BMS3394 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.462 between residues 22 and 23 862908012913 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012914 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 862908012915 catalytic center binding site [active] 862908012916 ATP binding site [chemical binding]; other site 862908012917 HMMPfam hit to PF01288, 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, score 9.1e-37 862908012918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862908012919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862908012920 active site 862908012921 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 5.4e-15 862908012922 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, central region, score 5.6e-45 862908012923 PS00072 Acyl-CoA dehydrogenases signature 1. 862908012924 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal, score 6.2e-77 862908012925 PS00073 Acyl-CoA dehydrogenases signature 2. 862908012926 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862908012927 Ligand binding site [chemical binding]; other site 862908012928 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862908012929 HMMPfam hit to PF01012, Electron transfer flavoprotein beta-subunit, score 1.5e-79 862908012930 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012931 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 862908012932 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862908012933 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862908012934 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862908012935 HMMPfam hit to PF00766, Electron transfer flavoprotein, alpha subunit, score 3.2e-95 862908012936 PS00696 Electron transfer flavoprotein alpha-subunit signature. 862908012937 Signal peptide predicted for BMS3399 by SignalP 2.0 HMM (Signal peptide probability 0.824) with cleavage site probability 0.325 between residues 21 and 22 862908012938 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 862908012939 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 862908012940 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 862908012941 Walker A motif; other site 862908012942 PS01215 Mrp family signature. 862908012943 2 probable transmembrane helices predicted for BMS3403 by TMHMM2.0 at aa 41-60 and 89-111 862908012944 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908012945 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908012946 catalytic residue [active] 862908012947 Signal peptide predicted for BMS3404 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.606 between residues 24 and 25 862908012948 HMMPfam hit to PF01464, SLT, score 1.6e-32 862908012949 PS00922 Prokaryotic transglycosylases signature. 862908012950 GTP-binding protein YchF; Reviewed; Region: PRK09601 862908012951 YchF GTPase; Region: YchF; cd01900 862908012952 G1 box; other site 862908012953 GTP/Mg2+ binding site [chemical binding]; other site 862908012954 Switch I region; other site 862908012955 G2 box; other site 862908012956 Switch II region; other site 862908012957 G3 box; other site 862908012958 G4 box; other site 862908012959 G5 box; other site 862908012960 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 862908012961 HMMPfam hit to PF06071, Conserved hypothetical protein 92, score 5.2e-59 862908012962 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.6e-31 862908012963 PS00017 ATP/GTP-binding site motif A (P-loop). 862908012964 PS00443 Glutamine amidotransferases class-II active site. 862908012965 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 862908012966 putative active site [active] 862908012967 catalytic residue [active] 862908012968 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 4.2e-67 862908012969 PS01196 Peptidyl-tRNA hydrolase signature 2. 862908012970 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 862908012971 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862908012972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862908012973 active site 862908012974 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.4e-31 862908012975 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 862908012976 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 862908012977 Transglycosylase; Region: Transgly; pfam00912 862908012978 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 862908012979 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 6.9e-51 862908012980 1 probable transmembrane helix predicted for BMS3408 by TMHMM2.0 at aa 9-31 862908012981 Signal peptide predicted for BMS3410 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 862908012982 Signal peptide predicted for BMS3411 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.888 between residues 18 and 19 862908012983 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 862908012984 active site 862908012985 tetramer interface; other site 862908012986 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.3e-11 862908012987 Signal peptide predicted for BMS3413 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.540 between residues 43 and 44 862908012988 Predicted permeases [General function prediction only]; Region: COG0795 862908012989 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862908012990 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 3.8e-22 862908012991 5 probable transmembrane helices predicted for BMS3415 by TMHMM2.0 at aa 15-37, 96-118, 282-300, 313-331 and 341-360 862908012992 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 862908012993 HMMPfam hit to PF02366, Glycosyl transferase, family 39, score 7.1e-05 862908012994 13 probable transmembrane helices predicted for BMS3416 by TMHMM2.0 at aa 12-29, 76-98, 111-130, 135-157, 162-179, 183-205, 212-234, 260-282, 294-311, 316-338, 350-372, 378-400 and 409-431 862908012995 HMMPfam hit to PF03183, Borrelia repeat protein, score 7.8 862908012996 HMMPfam hit to PF03183, Borrelia repeat protein, score 7 862908012997 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862908012998 active site 862908012999 catalytic residues [active] 862908013000 metal binding site [ion binding]; metal-binding site 862908013001 HMMPfam hit to PF01327, Formylmethionine deformylase, score 2.2e-60 862908013002 PS00017 ATP/GTP-binding site motif A (P-loop). 862908013003 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 862908013004 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 862908013005 putative active site [active] 862908013006 substrate binding site [chemical binding]; other site 862908013007 putative cosubstrate binding site; other site 862908013008 catalytic site [active] 862908013009 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 862908013010 substrate binding site [chemical binding]; other site 862908013011 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 9.7e-32 862908013012 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 2.7e-19 862908013013 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 862908013014 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862908013015 substrate binding site [chemical binding]; other site 862908013016 hexamer interface [polypeptide binding]; other site 862908013017 metal binding site [ion binding]; metal-binding site 862908013018 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 1.3e-67 862908013019 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 862908013020 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 862908013021 active sites [active] 862908013022 tetramer interface [polypeptide binding]; other site 862908013023 HMMPfam hit to PF00221, Phenylalanine/histidine ammonia-lyase, score 1.8e-219 862908013024 PS00488 Phenylalanine and histidine ammonia-lyases signature. 862908013025 imidazolonepropionase; Validated; Region: PRK09356 862908013026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862908013027 active site 862908013028 HMMPfam hit to PF01979, Amidohydrolase, score 0.0086 862908013029 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 862908013030 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862908013031 catalytic residues [active] 862908013032 1 probable transmembrane helix predicted for BMS3422 by TMHMM2.0 at aa 5-24 862908013033 Signal peptide predicted for BMS3422 by SignalP 2.0 HMM (Signal peptide probability 0.606) with cleavage site probability 0.419 between residues 20 and 21 862908013034 1 probable transmembrane helix predicted for BMS3423 by TMHMM2.0 at aa 39-58 862908013035 glycerol kinase; Region: glycerol_kin; TIGR01311 862908013036 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 862908013037 N- and C-terminal domain interface [polypeptide binding]; other site 862908013038 active site 862908013039 MgATP binding site [chemical binding]; other site 862908013040 catalytic site [active] 862908013041 metal binding site [ion binding]; metal-binding site 862908013042 glycerol binding site [chemical binding]; other site 862908013043 homotetramer interface [polypeptide binding]; other site 862908013044 homodimer interface [polypeptide binding]; other site 862908013045 FBP binding site [chemical binding]; other site 862908013046 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.2e-74 862908013047 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 3.1e-46 862908013048 DNA repair protein RadA; Provisional; Region: PRK11823 862908013049 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862908013050 Walker A motif; other site 862908013051 ATP binding site [chemical binding]; other site 862908013052 Walker B motif; other site 862908013053 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 862908013054 PS00017 ATP/GTP-binding site motif A (P-loop). 862908013055 PLD-like domain; Region: PLDc_2; pfam13091 862908013056 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908013057 putative active site [active] 862908013058 catalytic site [active] 862908013059 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862908013060 PLD-like domain; Region: PLDc_2; pfam13091 862908013061 putative active site [active] 862908013062 catalytic site [active] 862908013063 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 862908013064 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 862908013065 nucleotide binding pocket [chemical binding]; other site 862908013066 K-X-D-G motif; other site 862908013067 catalytic site [active] 862908013068 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 862908013069 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 862908013070 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 862908013071 Dimer interface [polypeptide binding]; other site 862908013072 HMMPfam hit to PF00533, BRCT, score 5.4e-12 862908013073 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold, score 1e-25 862908013074 HMMPfam hit to PF01653, NAD-dependent DNA ligase, score 8e-40 862908013075 PS01055 NAD-dependent DNA ligase signature 1. 862908013076 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 862908013077 DNA binding residues [nucleotide binding] 862908013078 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 862908013079 active site 862908013080 nucleophile elbow; other site 862908013081 HMMPfam hit to PF01734, Patatin, score 2.4e-11 862908013082 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862908013083 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862908013084 catalytic residue [active] 862908013085 Signal peptide predicted for BMS3432 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.640 between residues 16 and 17 862908013086 HMMPfam hit to PF01464, SLT, score 1.5e-15 862908013087 Signal peptide predicted for BMS3433 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.452 between residues 21 and 22 862908013088 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 862908013089 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 862908013090 gamma subunit interface [polypeptide binding]; other site 862908013091 epsilon subunit interface [polypeptide binding]; other site 862908013092 LBP interface [polypeptide binding]; other site 862908013093 HMMPfam hit to PF02823, H+-transporting two-sector ATPase, delta/epsilon subunit, score 1.3e-09 862908013094 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 862908013095 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 862908013096 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862908013097 alpha subunit interaction interface [polypeptide binding]; other site 862908013098 Walker A motif; other site 862908013099 ATP binding site [chemical binding]; other site 862908013100 Walker B motif; other site 862908013101 inhibitor binding site; inhibition site 862908013102 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862908013103 HMMPfam hit to PF00306, H+-transporting two-sector ATPase, alpha/beta subunit, C-terminal, score 4.2e-48 862908013104 HMMPfam hit to PF00006, H+-transporting two-sector ATPase, alpha/beta subunit, central region, score 5.9e-91 862908013105 PS00152 ATP synthase alpha and beta subunits signature. 862908013106 PS00017 ATP/GTP-binding site motif A (P-loop). 862908013107 HMMPfam hit to PF02874, H+-transporting two-sector ATPase, alpha/beta subunit, N-terminal, score 3.4e-30 862908013108 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 862908013109 core domain interface [polypeptide binding]; other site 862908013110 delta subunit interface [polypeptide binding]; other site 862908013111 epsilon subunit interface [polypeptide binding]; other site 862908013112 HMMPfam hit to PF00231, H+-transporting two-sector ATPase, gamma subunit, score 2.7e-87 862908013113 PS00153 ATP synthase gamma subunit signature. 862908013114 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 862908013115 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 862908013116 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 862908013117 beta subunit interaction interface [polypeptide binding]; other site 862908013118 Walker A motif; other site 862908013119 ATP binding site [chemical binding]; other site 862908013120 Walker B motif; other site 862908013121 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862908013122 HMMPfam hit to PF00306, H+-transporting two-sector ATPase, alpha/beta subunit, C-terminal, score 2.7e-32 862908013123 HMMPfam hit to PF00006, H+-transporting two-sector ATPase, alpha/beta subunit, central region, score 8.8e-116 862908013124 PS00152 ATP synthase alpha and beta subunits signature. 862908013125 PS00017 ATP/GTP-binding site motif A (P-loop). 862908013126 HMMPfam hit to PF02874, H+-transporting two-sector ATPase, alpha/beta subunit, N-terminal, score 9.7e-19 862908013127 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 862908013128 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 862908013129 HMMPfam hit to PF00213, H+-transporting two-sector ATPase, delta (OSCP) subunit, score 1.6e-06 862908013130 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 862908013131 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 862908013132 HMMPfam hit to PF00430, H+-transporting two-sector ATPase, B/B' subunit, score 6.4e-05 862908013133 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 862908013134 HMMPfam hit to PF00430, H+-transporting two-sector ATPase, B/B' subunit, score 0.00018 862908013135 1 probable transmembrane helix predicted for BMS3440 by TMHMM2.0 at aa 15-37 862908013136 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 862908013137 HMMPfam hit to PF04519, Protein of unknown function DUF583, score 1.6e-24 862908013138 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 862908013139 ParB-like nuclease domain; Region: ParB; smart00470 862908013140 KorB domain; Region: KorB; pfam08535 862908013141 HMMPfam hit to PF02195, ParB-like nuclease, score 1e-34 862908013142 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862908013143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908013144 P-loop; other site 862908013145 Magnesium ion binding site [ion binding]; other site 862908013146 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862908013147 Magnesium ion binding site [ion binding]; other site 862908013148 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 4.6e-54 862908013149 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 862908013150 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 862908013151 HMMPfam hit to PF02527, Glucose inhibited division protein, score 5.7e-15 862908013152 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 862908013153 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 862908013154 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 862908013155 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 862908013156 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 1.1e-154 862908013157 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 862908013158 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 862908013159 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862908013160 G1 box; other site 862908013161 GTP/Mg2+ binding site [chemical binding]; other site 862908013162 G2 box; other site 862908013163 Switch I region; other site 862908013164 G3 box; other site 862908013165 Switch II region; other site 862908013166 G4 box; other site 862908013167 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 862908013168 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.6e-23 862908013169 PS00017 ATP/GTP-binding site motif A (P-loop). 862908013170 membrane protein insertase; Provisional; Region: PRK01318 862908013171 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 862908013172 HMMPfam hit to PF02096, 60 kDa inner membrane protein, score 8.5e-96 862908013173 4 probable transmembrane helices predicted for BMS3448 by TMHMM2.0 at aa 9-26, 302-324, 371-393 and 448-470 862908013174 Ribonuclease P; Region: Ribonuclease_P; pfam00825 862908013175 HMMPfam hit to PF00825, Bacterial ribonuclease P protein, score 3.6e-10 862908013176 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 862908013177 HMMPfam hit to PF00468, Ribosomal protein L34, score 4.1e-16 862908013178 PS00784 Ribosomal protein L34 signature. 862908013179 Initiator Replication protein; Region: Rep_3; pfam01051