-- dump date   	20140619_000448
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
693979000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
693979000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
693979000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979000004	Walker A motif; other site
693979000005	ATP binding site [chemical binding]; other site
693979000006	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
693979000007	DnaA box-binding interface [nucleotide binding]; other site
693979000008	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
693979000009	dimer interface [polypeptide binding]; other site
693979000010	FMN binding site [chemical binding]; other site
693979000011	NADPH bind site [chemical binding]; other site
693979000012	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
693979000013	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
693979000014	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
693979000015	active site
693979000016	dimer interface [polypeptide binding]; other site
693979000017	effector binding site; other site
693979000018	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
693979000019	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
693979000020	4-alpha-glucanotransferase; Region: PLN02950
693979000021	starch-binding site 2 [chemical binding]; other site
693979000022	starch-binding site 1 [chemical binding]; other site
693979000023	Disproportionating enzyme 2 (DPE2), N-terminal CBM20 (carbohydrate-binding module, family 20) domain, repeat 2. DPE2 is a transglucosidase that is essential for the cytosolic metabolism of maltose in plant leaves at night. Maltose is an intermediate on...; Region: CBM20_DPE2_repeat2; cd05816
693979000024	starch binding site 2 [chemical binding]; other site
693979000025	starch binding site 1 [chemical binding]; other site
693979000026	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
693979000027	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
693979000028	active site
693979000029	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
693979000030	N-acetyl-D-glucosamine binding site [chemical binding]; other site
693979000031	catalytic residue [active]
693979000032	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
693979000033	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
693979000034	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
693979000035	active site
693979000036	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
693979000037	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979000038	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979000039	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000040	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000041	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979000042	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979000043	FecR protein; Region: FecR; pfam04773
693979000044	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979000045	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979000046	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979000047	DNA binding residues [nucleotide binding]
693979000048	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
693979000049	active site
693979000050	dimer interfaces [polypeptide binding]; other site
693979000051	catalytic residues [active]
693979000052	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979000053	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
693979000054	Probable Catalytic site; other site
693979000055	metal-binding site
693979000056	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
693979000057	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693979000058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979000059	FeS/SAM binding site; other site
693979000060	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693979000061	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979000062	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
693979000063	putative AMP binding site [chemical binding]; other site
693979000064	putative active site [active]
693979000065	acyl-activating enzyme (AAE) consensus motif; other site
693979000066	putative CoA binding site [chemical binding]; other site
693979000067	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
693979000068	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
693979000069	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
693979000070	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
693979000071	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
693979000072	MarR family; Region: MarR_2; cl17246
693979000073	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
693979000074	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693979000075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000076	active site
693979000077	phosphorylation site [posttranslational modification]
693979000078	intermolecular recognition site; other site
693979000079	dimerization interface [polypeptide binding]; other site
693979000080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693979000081	DNA binding site [nucleotide binding]
693979000082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000084	dimer interface [polypeptide binding]; other site
693979000085	phosphorylation site [posttranslational modification]
693979000086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000087	ATP binding site [chemical binding]; other site
693979000088	Mg2+ binding site [ion binding]; other site
693979000089	G-X-G motif; other site
693979000090	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
693979000091	elongation factor G; Reviewed; Region: PRK12740
693979000092	G1 box; other site
693979000093	putative GEF interaction site [polypeptide binding]; other site
693979000094	GTP/Mg2+ binding site [chemical binding]; other site
693979000095	Switch I region; other site
693979000096	G2 box; other site
693979000097	G3 box; other site
693979000098	Switch II region; other site
693979000099	G4 box; other site
693979000100	G5 box; other site
693979000101	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
693979000102	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
693979000103	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
693979000104	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
693979000105	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979000106	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979000107	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979000108	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
693979000109	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
693979000110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979000111	FeS/SAM binding site; other site
693979000112	HemN C-terminal domain; Region: HemN_C; pfam06969
693979000113	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979000114	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979000115	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979000116	DNA binding residues [nucleotide binding]
693979000117	FecR protein; Region: FecR; pfam04773
693979000118	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979000119	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979000120	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000121	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979000122	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979000123	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
693979000124	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979000125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000126	active site
693979000127	phosphorylation site [posttranslational modification]
693979000128	intermolecular recognition site; other site
693979000129	dimerization interface [polypeptide binding]; other site
693979000130	LytTr DNA-binding domain; Region: LytTR; smart00850
693979000131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000132	binding surface
693979000133	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000134	TPR motif; other site
693979000135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000136	binding surface
693979000137	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000138	TPR motif; other site
693979000139	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000140	Histidine kinase; Region: His_kinase; pfam06580
693979000141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000142	ATP binding site [chemical binding]; other site
693979000143	Mg2+ binding site [ion binding]; other site
693979000144	G-X-G motif; other site
693979000145	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000146	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000147	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000148	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
693979000149	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
693979000150	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
693979000151	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979000152	Sulfatase; Region: Sulfatase; pfam00884
693979000153	Domain of unknown function (DUF2027); Region: DUF2027; pfam09640
693979000154	Smr domain; Region: Smr; pfam01713
693979000155	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
693979000156	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
693979000157	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
693979000158	nudix motif; other site
693979000159	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
693979000160	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
693979000161	active site
693979000162	substrate binding site [chemical binding]; other site
693979000163	metal binding site [ion binding]; metal-binding site
693979000164	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
693979000165	DHH family; Region: DHH; pfam01368
693979000166	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
693979000167	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
693979000168	Competence protein; Region: Competence; pfam03772
693979000169	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
693979000170	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
693979000171	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979000172	Sulfatase; Region: Sulfatase; pfam00884
693979000173	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979000174	Sulfatase; Region: Sulfatase; pfam00884
693979000175	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000176	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000177	SusD family; Region: SusD; pfam07980
693979000178	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000179	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000180	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000181	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979000182	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000183	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
693979000184	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
693979000185	substrate binding site [chemical binding]; other site
693979000186	hexamer interface [polypeptide binding]; other site
693979000187	metal binding site [ion binding]; metal-binding site
693979000188	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
693979000189	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
693979000190	putative active site [active]
693979000191	substrate binding site [chemical binding]; other site
693979000192	putative cosubstrate binding site; other site
693979000193	catalytic site [active]
693979000194	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
693979000195	substrate binding site [chemical binding]; other site
693979000196	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
693979000197	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
693979000198	Cl- selectivity filter; other site
693979000199	Cl- binding residues [ion binding]; other site
693979000200	pore gating glutamate residue; other site
693979000201	dimer interface [polypeptide binding]; other site
693979000202	FOG: CBS domain [General function prediction only]; Region: COG0517
693979000203	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
693979000204	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
693979000205	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693979000206	active site
693979000207	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
693979000208	putative dimerization interface [polypeptide binding]; other site
693979000209	Transcriptional regulators [Transcription]; Region: PurR; COG1609
693979000210	putative ligand binding site [chemical binding]; other site
693979000211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979000212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000213	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
693979000214	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
693979000215	putative active site [active]
693979000216	putative metal binding site [ion binding]; other site
693979000217	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
693979000218	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979000219	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
693979000220	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979000221	active site
693979000222	Fn3 associated; Region: Fn3_assoc; pfam13287
693979000223	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979000224	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
693979000225	Uncharacterized conserved protein [Function unknown]; Region: COG3538
693979000226	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
693979000227	Trehalase; Region: Trehalase; cl17346
693979000228	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
693979000229	dimer interface [polypeptide binding]; other site
693979000230	Alkaline phosphatase homologues; Region: alkPPc; smart00098
693979000231	active site
693979000232	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
693979000233	putative catalytic site [active]
693979000234	putative metal binding site [ion binding]; other site
693979000235	putative phosphate binding site [ion binding]; other site
693979000236	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979000237	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979000238	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
693979000239	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
693979000240	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000241	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000242	SusD family; Region: SusD; pfam07980
693979000243	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000244	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000245	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979000247	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693979000248	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
693979000249	nucleotide binding site [chemical binding]; other site
693979000250	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
693979000251	active site
693979000252	catalytic site [active]
693979000253	putative metal binding site [ion binding]; other site
693979000254	Divergent AAA domain; Region: AAA_4; pfam04326
693979000255	hypothetical protein; Validated; Region: PRK02101
693979000256	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
693979000257	DHH family; Region: DHH; pfam01368
693979000258	DHHA1 domain; Region: DHHA1; pfam02272
693979000259	DEAD-like helicases superfamily; Region: DEXDc; smart00487
693979000260	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979000261	ATP binding site [chemical binding]; other site
693979000262	putative Mg++ binding site [ion binding]; other site
693979000263	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979000264	nucleotide binding region [chemical binding]; other site
693979000265	ATP-binding site [chemical binding]; other site
693979000266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000267	binding surface
693979000268	TPR motif; other site
693979000269	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979000270	TPR repeat; Region: TPR_11; pfam13414
693979000271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000272	binding surface
693979000273	TPR motif; other site
693979000274	TPR repeat; Region: TPR_11; pfam13414
693979000275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000276	binding surface
693979000277	TPR motif; other site
693979000278	TPR repeat; Region: TPR_11; pfam13414
693979000279	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
693979000280	Prephenate dehydratase; Region: PDT; pfam00800
693979000281	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
693979000282	putative L-Phe binding site [chemical binding]; other site
693979000283	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
693979000284	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979000285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979000286	homodimer interface [polypeptide binding]; other site
693979000287	catalytic residue [active]
693979000288	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
693979000289	Chorismate mutase type II; Region: CM_2; smart00830
693979000290	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
693979000291	prephenate dehydrogenase; Validated; Region: PRK08507
693979000292	DNA primase, catalytic core; Region: dnaG; TIGR01391
693979000293	CHC2 zinc finger; Region: zf-CHC2; pfam01807
693979000294	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
693979000295	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
693979000296	active site
693979000297	metal binding site [ion binding]; metal-binding site
693979000298	interdomain interaction site; other site
693979000299	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
693979000300	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
693979000301	homodecamer interface [polypeptide binding]; other site
693979000302	GTP cyclohydrolase I; Provisional; Region: PLN03044
693979000303	active site
693979000304	putative catalytic site residues [active]
693979000305	zinc binding site [ion binding]; other site
693979000306	GTP-CH-I/GFRP interaction surface; other site
693979000307	Sporulation related domain; Region: SPOR; pfam05036
693979000308	triosephosphate isomerase; Provisional; Region: PRK14567
693979000309	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
693979000310	substrate binding site [chemical binding]; other site
693979000311	dimer interface [polypeptide binding]; other site
693979000312	catalytic triad [active]
693979000313	Predicted membrane protein [Function unknown]; Region: COG2259
693979000314	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
693979000315	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
693979000316	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
693979000317	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979000318	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979000319	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
693979000320	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
693979000321	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
693979000322	generic binding surface II; other site
693979000323	ssDNA binding site; other site
693979000324	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979000325	ATP binding site [chemical binding]; other site
693979000326	putative Mg++ binding site [ion binding]; other site
693979000327	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979000328	nucleotide binding region [chemical binding]; other site
693979000329	ATP-binding site [chemical binding]; other site
693979000330	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
693979000331	substrate binding site; other site
693979000332	dimer interface; other site
693979000333	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
693979000334	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
693979000335	conserved cys residue [active]
693979000336	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
693979000337	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
693979000338	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
693979000339	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
693979000340	active site
693979000341	hydrophilic channel; other site
693979000342	dimerization interface [polypeptide binding]; other site
693979000343	catalytic residues [active]
693979000344	active site lid [active]
693979000345	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911
693979000346	ATP-NAD kinase; Region: NAD_kinase; pfam01513
693979000347	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979000348	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
693979000349	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979000350	active site
693979000351	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979000352	beta-D-glucuronidase; Provisional; Region: PRK10150
693979000353	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979000354	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979000355	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
693979000356	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
693979000357	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000358	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979000359	SusD family; Region: SusD; pfam07980
693979000360	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000361	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000362	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000363	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000364	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979000365	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979000366	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000368	dimer interface [polypeptide binding]; other site
693979000369	phosphorylation site [posttranslational modification]
693979000370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000371	ATP binding site [chemical binding]; other site
693979000372	Mg2+ binding site [ion binding]; other site
693979000373	G-X-G motif; other site
693979000374	Response regulator receiver domain; Region: Response_reg; pfam00072
693979000375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000376	active site
693979000377	phosphorylation site [posttranslational modification]
693979000378	intermolecular recognition site; other site
693979000379	dimerization interface [polypeptide binding]; other site
693979000380	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979000381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000382	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979000383	Sulfatase; Region: Sulfatase; pfam00884
693979000384	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979000385	Sulfatase; Region: Sulfatase; pfam00884
693979000386	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000387	SusD family; Region: SusD; pfam07980
693979000388	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979000389	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000390	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000391	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000392	FecR protein; Region: FecR; pfam04773
693979000393	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979000394	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979000395	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979000396	DNA binding residues [nucleotide binding]
693979000397	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979000398	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979000399	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
693979000400	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979000401	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693979000402	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979000403	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693979000404	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
693979000405	Domain interface; other site
693979000406	Peptide binding site; other site
693979000407	Active site tetrad [active]
693979000408	malate dehydrogenase; Reviewed; Region: PRK06223
693979000409	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
693979000410	dimer interface [polypeptide binding]; other site
693979000411	NAD(P) binding site [chemical binding]; other site
693979000412	tetramer (dimer of dimers) interface [polypeptide binding]; other site
693979000413	substrate binding site [chemical binding]; other site
693979000414	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693979000415	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
693979000416	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693979000417	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979000418	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
693979000419	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
693979000420	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
693979000421	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
693979000422	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
693979000423	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
693979000424	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
693979000425	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979000426	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000427	Calx-beta domain; Region: Calx-beta; cl02522
693979000428	TPR repeat; Region: TPR_11; pfam13414
693979000429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000430	TPR motif; other site
693979000431	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979000432	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979000433	ligand binding site [chemical binding]; other site
693979000434	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979000435	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979000436	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979000437	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979000438	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
693979000439	active site
693979000440	DNA binding site [nucleotide binding]
693979000441	Int/Topo IB signature motif; other site
693979000442	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
693979000443	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
693979000444	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
693979000445	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
693979000446	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
693979000447	CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596
693979000448	putative active site [active]
693979000449	putative catalytic site [active]
693979000450	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
693979000451	Interdomain contacts; other site
693979000452	Cytokine receptor motif; other site
693979000453	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979000454	sugar binding site [chemical binding]; other site
693979000455	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
693979000456	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979000457	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000458	SusD family; Region: SusD; pfam07980
693979000459	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979000460	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000461	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000462	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000463	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979000464	FecR protein; Region: FecR; pfam04773
693979000465	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979000466	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979000467	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979000468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979000469	DNA binding residues [nucleotide binding]
693979000470	Penicillinase repressor; Region: Pencillinase_R; pfam03965
693979000471	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
693979000472	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979000473	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979000474	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979000475	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979000476	Domain of unknown function DUF59; Region: DUF59; pfam01883
693979000477	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
693979000478	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
693979000479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979000480	S-adenosylmethionine binding site [chemical binding]; other site
693979000481	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
693979000482	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
693979000483	homodimer interface [polypeptide binding]; other site
693979000484	substrate-cofactor binding pocket; other site
693979000485	catalytic residue [active]
693979000486	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
693979000487	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
693979000488	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
693979000489	generic binding surface II; other site
693979000490	generic binding surface I; other site
693979000491	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
693979000492	active site
693979000493	catalytic triad [active]
693979000494	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: PRK14664
693979000495	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
693979000496	Ligand Binding Site [chemical binding]; other site
693979000497	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
693979000498	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
693979000499	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979000500	putative active site [active]
693979000501	putative metal binding site [ion binding]; other site
693979000502	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
693979000503	homotrimer interaction site [polypeptide binding]; other site
693979000504	zinc binding site [ion binding]; other site
693979000505	CDP-binding sites; other site
693979000506	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
693979000507	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
693979000508	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
693979000509	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
693979000510	CoA binding domain; Region: CoA_binding; pfam02629
693979000511	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
693979000512	putative rRNA binding site [nucleotide binding]; other site
693979000513	elongation factor Ts; Provisional; Region: tsf; PRK09377
693979000514	UBA/TS-N domain; Region: UBA; pfam00627
693979000515	Elongation factor TS; Region: EF_TS; pfam00889
693979000516	Elongation factor TS; Region: EF_TS; pfam00889
693979000517	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
693979000518	rRNA interaction site [nucleotide binding]; other site
693979000519	S8 interaction site; other site
693979000520	putative laminin-1 binding site; other site
693979000521	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
693979000522	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
693979000523	23S rRNA interface [nucleotide binding]; other site
693979000524	glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157
693979000525	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
693979000526	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
693979000527	putative dimer interface [polypeptide binding]; other site
693979000528	putative anticodon binding site; other site
693979000529	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
693979000530	homodimer interface [polypeptide binding]; other site
693979000531	motif 1; other site
693979000532	motif 2; other site
693979000533	active site
693979000534	motif 3; other site
693979000535	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
693979000536	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693979000537	RNA binding surface [nucleotide binding]; other site
693979000538	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
693979000539	active site
693979000540	adenylosuccinate lyase; Provisional; Region: PRK09285
693979000541	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
693979000542	tetramer interface [polypeptide binding]; other site
693979000543	active site
693979000544	maltose O-acetyltransferase; Provisional; Region: PRK10092
693979000545	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
693979000546	active site
693979000547	substrate binding site [chemical binding]; other site
693979000548	trimer interface [polypeptide binding]; other site
693979000549	CoA binding site [chemical binding]; other site
693979000550	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
693979000551	dimer interface [polypeptide binding]; other site
693979000552	putative tRNA-binding site [nucleotide binding]; other site
693979000553	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
693979000554	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693979000555	ATP-grasp domain; Region: ATP-grasp_4; cl17255
693979000556	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
693979000557	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693979000558	ATP-grasp domain; Region: ATP-grasp_4; cl17255
693979000559	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
693979000560	probable substrate binding site [chemical binding]; other site
693979000561	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
693979000562	putative catalytic site [active]
693979000563	putative metal binding site [ion binding]; other site
693979000564	putative phosphate binding site [ion binding]; other site
693979000565	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000566	SusD family; Region: SusD; pfam07980
693979000567	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000568	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000569	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000570	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000571	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000572	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
693979000573	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979000574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000575	RteC protein; Region: RteC; pfam09357
693979000576	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979000577	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
693979000578	active site
693979000579	metal binding site [ion binding]; metal-binding site
693979000580	interdomain interaction site; other site
693979000581	AAA domain; Region: AAA_25; pfam13481
693979000582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
693979000583	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979000584	RibD C-terminal domain; Region: RibD_C; cl17279
693979000585	DNA topoisomerase III; Provisional; Region: PRK07726
693979000586	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
693979000587	active site
693979000588	putative interdomain interaction site [polypeptide binding]; other site
693979000589	putative metal-binding site [ion binding]; other site
693979000590	putative nucleotide binding site [chemical binding]; other site
693979000591	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
693979000592	domain I; other site
693979000593	DNA binding groove [nucleotide binding]
693979000594	phosphate binding site [ion binding]; other site
693979000595	domain II; other site
693979000596	domain III; other site
693979000597	nucleotide binding site [chemical binding]; other site
693979000598	catalytic site [active]
693979000599	domain IV; other site
693979000600	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
693979000601	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
693979000602	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
693979000603	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
693979000604	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979000605	active site
693979000606	DNA binding site [nucleotide binding]
693979000607	Int/Topo IB signature motif; other site
693979000608	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979000609	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
693979000610	4Fe-4S binding domain; Region: Fer4; pfam00037
693979000611	Predicted transcriptional regulators [Transcription]; Region: COG1733
693979000612	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
693979000613	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979000614	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979000615	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979000616	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
693979000617	Int/Topo IB signature motif; other site
693979000618	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979000619	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
693979000620	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
693979000621	active site
693979000622	HIGH motif; other site
693979000623	dimer interface [polypeptide binding]; other site
693979000624	KMSKS motif; other site
693979000625	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
693979000626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000627	ATP binding site [chemical binding]; other site
693979000628	Mg2+ binding site [ion binding]; other site
693979000629	G-X-G motif; other site
693979000630	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
693979000631	ATP binding site [chemical binding]; other site
693979000632	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
693979000633	OstA-like protein; Region: OstA_2; pfam13100
693979000634	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
693979000635	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
693979000636	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
693979000637	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
693979000638	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
693979000639	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
693979000640	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
693979000641	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
693979000642	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
693979000643	active site
693979000644	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
693979000645	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979000646	ATP binding site [chemical binding]; other site
693979000647	putative Mg++ binding site [ion binding]; other site
693979000648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979000649	nucleotide binding region [chemical binding]; other site
693979000650	ATP-binding site [chemical binding]; other site
693979000651	RQC domain; Region: RQC; pfam09382
693979000652	HRDC domain; Region: HRDC; pfam00570
693979000653	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
693979000654	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
693979000655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979000656	Walker A motif; other site
693979000657	ATP binding site [chemical binding]; other site
693979000658	Walker B motif; other site
693979000659	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
693979000660	Clp protease; Region: CLP_protease; pfam00574
693979000661	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
693979000662	oligomer interface [polypeptide binding]; other site
693979000663	active site residues [active]
693979000664	trigger factor; Region: tig; TIGR00115
693979000665	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
693979000666	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
693979000667	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
693979000668	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
693979000669	Walker A/P-loop; other site
693979000670	ATP binding site [chemical binding]; other site
693979000671	Q-loop/lid; other site
693979000672	ABC transporter signature motif; other site
693979000673	Walker B; other site
693979000674	D-loop; other site
693979000675	H-loop/switch region; other site
693979000676	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
693979000677	Permease; Region: Permease; pfam02405
693979000678	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
693979000679	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
693979000680	Walker A/P-loop; other site
693979000681	ATP binding site [chemical binding]; other site
693979000682	Q-loop/lid; other site
693979000683	ABC transporter signature motif; other site
693979000684	Walker B; other site
693979000685	D-loop; other site
693979000686	H-loop/switch region; other site
693979000687	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979000688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000689	active site
693979000690	phosphorylation site [posttranslational modification]
693979000691	intermolecular recognition site; other site
693979000692	dimerization interface [polypeptide binding]; other site
693979000693	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979000694	DNA binding residues [nucleotide binding]
693979000695	dimerization interface [polypeptide binding]; other site
693979000696	GTP-binding protein Der; Reviewed; Region: PRK00093
693979000697	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
693979000698	G1 box; other site
693979000699	GTP/Mg2+ binding site [chemical binding]; other site
693979000700	Switch I region; other site
693979000701	G2 box; other site
693979000702	Switch II region; other site
693979000703	G3 box; other site
693979000704	G4 box; other site
693979000705	G5 box; other site
693979000706	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
693979000707	G1 box; other site
693979000708	GTP/Mg2+ binding site [chemical binding]; other site
693979000709	Switch I region; other site
693979000710	G2 box; other site
693979000711	G3 box; other site
693979000712	Switch II region; other site
693979000713	G4 box; other site
693979000714	G5 box; other site
693979000715	GTPase Era; Reviewed; Region: era; PRK00089
693979000716	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
693979000717	G1 box; other site
693979000718	GTP/Mg2+ binding site [chemical binding]; other site
693979000719	Switch I region; other site
693979000720	G2 box; other site
693979000721	Switch II region; other site
693979000722	G3 box; other site
693979000723	G4 box; other site
693979000724	G5 box; other site
693979000725	KH domain; Region: KH_2; pfam07650
693979000726	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
693979000727	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
693979000728	dimer interface [polypeptide binding]; other site
693979000729	active site
693979000730	CoA binding pocket [chemical binding]; other site
693979000731	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
693979000732	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
693979000733	Septum formation initiator; Region: DivIC; pfam04977
693979000734	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
693979000735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979000736	Walker A motif; other site
693979000737	ATP binding site [chemical binding]; other site
693979000738	Walker B motif; other site
693979000739	arginine finger; other site
693979000740	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000741	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000742	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000743	dimer interface [polypeptide binding]; other site
693979000744	phosphorylation site [posttranslational modification]
693979000745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000746	ATP binding site [chemical binding]; other site
693979000747	Mg2+ binding site [ion binding]; other site
693979000748	G-X-G motif; other site
693979000749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000752	dimer interface [polypeptide binding]; other site
693979000753	phosphorylation site [posttranslational modification]
693979000754	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
693979000755	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
693979000756	aspartate aminotransferase; Provisional; Region: PRK05764
693979000757	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979000758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979000759	homodimer interface [polypeptide binding]; other site
693979000760	catalytic residue [active]
693979000761	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
693979000762	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
693979000763	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
693979000764	dimerization interface [polypeptide binding]; other site
693979000765	active site
693979000766	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
693979000767	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
693979000768	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
693979000769	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
693979000770	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
693979000771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
693979000772	dimerization interface [polypeptide binding]; other site
693979000773	PAS domain; Region: PAS; smart00091
693979000774	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
693979000775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000776	dimer interface [polypeptide binding]; other site
693979000777	phosphorylation site [posttranslational modification]
693979000778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000779	ATP binding site [chemical binding]; other site
693979000780	Mg2+ binding site [ion binding]; other site
693979000781	G-X-G motif; other site
693979000782	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
693979000783	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
693979000784	Ligand Binding Site [chemical binding]; other site
693979000785	K+-transporting ATPase, c chain; Region: KdpC; cl00944
693979000786	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
693979000787	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
693979000788	Soluble P-type ATPase [General function prediction only]; Region: COG4087
693979000789	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
693979000790	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
693979000791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000792	active site
693979000793	phosphorylation site [posttranslational modification]
693979000794	intermolecular recognition site; other site
693979000795	dimerization interface [polypeptide binding]; other site
693979000796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979000797	Walker A motif; other site
693979000798	ATP binding site [chemical binding]; other site
693979000799	Walker B motif; other site
693979000800	arginine finger; other site
693979000801	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979000802	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
693979000803	active site
693979000804	catalytic triad [active]
693979000805	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
693979000806	dimerization interface [polypeptide binding]; other site
693979000807	putative active cleft [active]
693979000808	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
693979000809	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
693979000810	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
693979000811	active site
693979000812	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
693979000813	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979000814	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000815	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000816	SusD family; Region: SusD; pfam07980
693979000817	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000818	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000819	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000820	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979000821	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000822	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
693979000823	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
693979000824	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
693979000825	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
693979000826	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000827	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979000828	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979000829	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979000830	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979000831	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979000832	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979000833	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979000834	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
693979000835	active site
693979000836	catalytic tetrad [active]
693979000837	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
693979000838	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000839	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000840	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000841	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000842	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979000843	SusD family; Region: SusD; pfam07980
693979000844	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
693979000845	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979000846	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
693979000847	Beta-lactamase; Region: Beta-lactamase; cl17358
693979000848	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
693979000849	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
693979000850	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
693979000851	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
693979000852	Beta-lactamase; Region: Beta-lactamase; cl17358
693979000853	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
693979000854	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
693979000855	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979000856	active site
693979000857	metal binding site [ion binding]; metal-binding site
693979000858	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
693979000859	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
693979000860	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
693979000861	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693979000862	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979000863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000864	active site
693979000865	phosphorylation site [posttranslational modification]
693979000866	intermolecular recognition site; other site
693979000867	dimerization interface [polypeptide binding]; other site
693979000868	LytTr DNA-binding domain; Region: LytTR; smart00850
693979000869	Histidine kinase; Region: His_kinase; pfam06580
693979000870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000871	ATP binding site [chemical binding]; other site
693979000872	Mg2+ binding site [ion binding]; other site
693979000873	G-X-G motif; other site
693979000874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000875	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000876	dimer interface [polypeptide binding]; other site
693979000877	phosphorylation site [posttranslational modification]
693979000878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000879	ATP binding site [chemical binding]; other site
693979000880	Mg2+ binding site [ion binding]; other site
693979000881	G-X-G motif; other site
693979000882	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979000883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979000884	binding surface
693979000885	TPR motif; other site
693979000886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000888	dimer interface [polypeptide binding]; other site
693979000889	phosphorylation site [posttranslational modification]
693979000890	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693979000891	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
693979000892	nucleotide binding site [chemical binding]; other site
693979000893	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979000894	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979000895	Walker A/P-loop; other site
693979000896	ATP binding site [chemical binding]; other site
693979000897	Q-loop/lid; other site
693979000898	ABC transporter signature motif; other site
693979000899	Walker B; other site
693979000900	D-loop; other site
693979000901	H-loop/switch region; other site
693979000902	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979000903	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979000904	FtsX-like permease family; Region: FtsX; pfam02687
693979000905	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979000906	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979000907	FtsX-like permease family; Region: FtsX; pfam02687
693979000908	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979000909	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979000910	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979000911	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
693979000912	Transglycosylase; Region: Transgly; pfam00912
693979000913	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
693979000914	S1 domain; Region: S1_2; pfam13509
693979000915	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979000916	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000917	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
693979000918	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979000919	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979000920	ligand binding site [chemical binding]; other site
693979000921	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979000922	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
693979000923	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
693979000924	Tic20-like protein; Region: Tic20; pfam09685
693979000925	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
693979000926	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
693979000927	NAD(P) binding site [chemical binding]; other site
693979000928	LDH/MDH dimer interface [polypeptide binding]; other site
693979000929	substrate binding site [chemical binding]; other site
693979000930	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000931	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979000932	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979000933	Peptidase M60-like family; Region: M60-like; pfam13402
693979000934	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979000935	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979000936	SusD family; Region: SusD; pfam07980
693979000937	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979000938	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979000939	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000940	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979000941	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979000942	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979000943	FecR protein; Region: FecR; pfam04773
693979000944	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979000945	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979000946	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979000947	DNA binding residues [nucleotide binding]
693979000948	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979000949	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
693979000950	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
693979000951	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
693979000952	Coenzyme A binding pocket [chemical binding]; other site
693979000953	argininosuccinate synthase; Provisional; Region: PRK13820
693979000954	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
693979000955	Ligand Binding Site [chemical binding]; other site
693979000956	PspC domain; Region: PspC; pfam04024
693979000957	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
693979000958	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
693979000959	acetylornithine aminotransferase; Provisional; Region: PRK02627
693979000960	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693979000961	inhibitor-cofactor binding pocket; inhibition site
693979000962	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979000963	catalytic residue [active]
693979000964	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979000965	Histidine kinase; Region: His_kinase; pfam06580
693979000966	Histidine kinase; Region: His_kinase; pfam06580
693979000967	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979000968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979000969	active site
693979000970	phosphorylation site [posttranslational modification]
693979000971	intermolecular recognition site; other site
693979000972	dimerization interface [polypeptide binding]; other site
693979000973	LytTr DNA-binding domain; Region: LytTR; smart00850
693979000974	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979000975	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979000976	DNA binding residues [nucleotide binding]
693979000977	dimerization interface [polypeptide binding]; other site
693979000978	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
693979000979	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979000980	Coenzyme A binding pocket [chemical binding]; other site
693979000981	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
693979000982	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
693979000983	acyl-activating enzyme (AAE) consensus motif; other site
693979000984	AMP binding site [chemical binding]; other site
693979000985	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979000986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979000987	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
693979000988	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
693979000989	PAS domain; Region: PAS_9; pfam13426
693979000990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979000991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979000992	dimer interface [polypeptide binding]; other site
693979000993	phosphorylation site [posttranslational modification]
693979000994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979000995	ATP binding site [chemical binding]; other site
693979000996	Mg2+ binding site [ion binding]; other site
693979000997	G-X-G motif; other site
693979000998	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979000999	non-specific DNA binding site [nucleotide binding]; other site
693979001000	salt bridge; other site
693979001001	sequence-specific DNA binding site [nucleotide binding]; other site
693979001002	Cupin domain; Region: Cupin_2; pfam07883
693979001003	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979001004	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
693979001005	acyl-activating enzyme (AAE) consensus motif; other site
693979001006	AMP binding site [chemical binding]; other site
693979001007	active site
693979001008	CoA binding site [chemical binding]; other site
693979001009	ORF6N domain; Region: ORF6N; pfam10543
693979001010	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979001011	hypothetical protein; Validated; Region: PRK08116
693979001012	nicotinate phosphoribosyltransferase; Region: PLN02885
693979001013	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055
693979001014	DnaA box-binding interface [nucleotide binding]; other site
693979001015	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979001016	non-specific DNA binding site [nucleotide binding]; other site
693979001017	salt bridge; other site
693979001018	sequence-specific DNA binding site [nucleotide binding]; other site
693979001019	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
693979001020	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
693979001021	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979001022	non-specific DNA binding site [nucleotide binding]; other site
693979001023	salt bridge; other site
693979001024	sequence-specific DNA binding site [nucleotide binding]; other site
693979001025	argininosuccinate lyase; Provisional; Region: PRK00855
693979001026	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
693979001027	active sites [active]
693979001028	tetramer interface [polypeptide binding]; other site
693979001029	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
693979001030	hydrophobic ligand binding site; other site
693979001031	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979001032	active site
693979001033	RecX family; Region: RecX; pfam02631
693979001034	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
693979001035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979001036	S-adenosylmethionine binding site [chemical binding]; other site
693979001037	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
693979001038	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
693979001039	catalytic motif [active]
693979001040	Zn binding site [ion binding]; other site
693979001041	RibD C-terminal domain; Region: RibD_C; cl17279
693979001042	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838
693979001043	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
693979001044	catalytic residue [active]
693979001045	putative FPP diphosphate  binding site; other site
693979001046	putative FPP binding hydrophobic cleft; other site
693979001047	dimer interface [polypeptide binding]; other site
693979001048	putative IPP diphosphate binding site; other site
693979001049	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
693979001050	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
693979001051	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
693979001052	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
693979001053	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
693979001054	Surface antigen; Region: Bac_surface_Ag; pfam01103
693979001055	periplasmic chaperone; Provisional; Region: PRK10780
693979001056	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
693979001057	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
693979001058	glutamate racemase; Provisional; Region: PRK00865
693979001059	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
693979001060	gamma-glutamyl kinase; Provisional; Region: PRK05429
693979001061	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
693979001062	nucleotide binding site [chemical binding]; other site
693979001063	homotetrameric interface [polypeptide binding]; other site
693979001064	putative phosphate binding site [ion binding]; other site
693979001065	putative allosteric binding site; other site
693979001066	PUA domain; Region: PUA; pfam01472
693979001067	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
693979001068	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
693979001069	putative catalytic cysteine [active]
693979001070	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
693979001071	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
693979001072	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
693979001073	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
693979001074	active site residue [active]
693979001075	NigD-like protein; Region: NigD; pfam12667
693979001076	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
693979001077	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
693979001078	ATP-grasp domain; Region: ATP-grasp_4; cl17255
693979001079	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
693979001080	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693979001081	RNA binding surface [nucleotide binding]; other site
693979001082	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693979001083	active site
693979001084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
693979001085	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
693979001086	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
693979001087	elongation factor P; Validated; Region: PRK00529
693979001088	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
693979001089	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
693979001090	RNA binding site [nucleotide binding]; other site
693979001091	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
693979001092	RNA binding site [nucleotide binding]; other site
693979001093	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979001094	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979001095	active site
693979001096	hypothetical protein; Reviewed; Region: PRK00024
693979001097	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
693979001098	MPN+ (JAMM) motif; other site
693979001099	Zinc-binding site [ion binding]; other site
693979001100	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
693979001101	catalytic motif [active]
693979001102	Catalytic residue [active]
693979001103	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979001104	sugar binding site [chemical binding]; other site
693979001105	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001106	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001107	SusD family; Region: SusD; pfam07980
693979001108	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001109	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001110	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001111	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001112	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
693979001113	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
693979001114	putative active site [active]
693979001115	putative metal binding site [ion binding]; other site
693979001116	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
693979001117	Alkaline phosphatase homologues; Region: alkPPc; smart00098
693979001118	active site
693979001119	dimer interface [polypeptide binding]; other site
693979001120	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
693979001121	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
693979001122	propionate/acetate kinase; Provisional; Region: PRK12379
693979001123	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
693979001124	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
693979001125	PEGA domain; Region: PEGA; pfam08308
693979001126	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
693979001127	LrgB-like family; Region: LrgB; pfam04172
693979001128	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
693979001129	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979001130	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979001131	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
693979001132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979001133	Coenzyme A binding pocket [chemical binding]; other site
693979001134	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
693979001135	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
693979001136	Uncharacterized conserved protein [Function unknown]; Region: COG1624
693979001137	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
693979001138	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
693979001139	dihydropteroate synthase; Region: DHPS; TIGR01496
693979001140	substrate binding pocket [chemical binding]; other site
693979001141	dimer interface [polypeptide binding]; other site
693979001142	inhibitor binding site; inhibition site
693979001143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979001144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001145	binding surface
693979001146	TPR motif; other site
693979001147	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001149	dimer interface [polypeptide binding]; other site
693979001150	phosphorylation site [posttranslational modification]
693979001151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001152	ATP binding site [chemical binding]; other site
693979001153	Mg2+ binding site [ion binding]; other site
693979001154	G-X-G motif; other site
693979001155	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
693979001156	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979001157	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693979001158	Predicted integral membrane protein [Function unknown]; Region: COG5652
693979001159	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
693979001160	Na2 binding site [ion binding]; other site
693979001161	putative substrate binding site 1 [chemical binding]; other site
693979001162	Na binding site 1 [ion binding]; other site
693979001163	putative substrate binding site 2 [chemical binding]; other site
693979001164	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
693979001165	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
693979001166	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
693979001167	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
693979001168	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
693979001169	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979001170	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979001171	Walker A/P-loop; other site
693979001172	ATP binding site [chemical binding]; other site
693979001173	Q-loop/lid; other site
693979001174	ABC transporter signature motif; other site
693979001175	Walker B; other site
693979001176	D-loop; other site
693979001177	H-loop/switch region; other site
693979001178	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001179	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001180	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001181	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979001182	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001183	SusD family; Region: SusD; pfam07980
693979001184	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
693979001185	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
693979001186	putative ATP binding site [chemical binding]; other site
693979001187	putative substrate interface [chemical binding]; other site
693979001188	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
693979001189	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
693979001190	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
693979001191	Ligand Binding Site [chemical binding]; other site
693979001192	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
693979001193	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
693979001194	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001195	SusD family; Region: SusD; pfam07980
693979001196	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001197	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001198	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001199	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979001200	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
693979001201	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001202	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001203	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001204	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001205	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001206	SusD family; Region: SusD; pfam07980
693979001207	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
693979001208	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
693979001209	Na binding site [ion binding]; other site
693979001210	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
693979001211	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
693979001212	active site
693979001213	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
693979001214	Interdomain contacts; other site
693979001215	Cytokine receptor motif; other site
693979001216	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
693979001217	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
693979001218	active site
693979001219	metal binding site [ion binding]; metal-binding site
693979001220	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
693979001221	Trp docking motif [polypeptide binding]; other site
693979001222	active site
693979001223	PQQ-like domain; Region: PQQ_2; pfam13360
693979001224	PQQ-like domain; Region: PQQ_2; pfam13360
693979001225	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
693979001226	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979001227	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979001228	active site
693979001229	GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103
693979001230	Stage II sporulation protein; Region: SpoIID; pfam08486
693979001231	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
693979001232	muropeptide transporter; Reviewed; Region: ampG; PRK11902
693979001233	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
693979001234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979001235	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
693979001236	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
693979001237	FAD binding domain; Region: FAD_binding_4; pfam01565
693979001238	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
693979001239	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
693979001240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
693979001241	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
693979001242	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
693979001243	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
693979001244	putative active site [active]
693979001245	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
693979001246	Beta-lactamase; Region: Beta-lactamase; pfam00144
693979001247	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
693979001248	active site
693979001249	catalytic triad [active]
693979001250	oxyanion hole [active]
693979001251	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
693979001252	glycyl-tRNA synthetase; Provisional; Region: PRK04173
693979001253	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
693979001254	motif 1; other site
693979001255	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
693979001256	active site
693979001257	motif 2; other site
693979001258	motif 3; other site
693979001259	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
693979001260	anticodon binding site; other site
693979001261	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
693979001262	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979001263	Virulence protein [General function prediction only]; Region: COG3943
693979001264	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979001265	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
693979001266	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
693979001267	CAP-like domain; other site
693979001268	active site
693979001269	primary dimer interface [polypeptide binding]; other site
693979001270	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
693979001271	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
693979001272	active site triad [active]
693979001273	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001274	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979001275	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001276	Predicted membrane protein [Function unknown]; Region: COG3174
693979001277	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
693979001278	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979001279	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979001280	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979001281	ligand binding site [chemical binding]; other site
693979001282	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
693979001283	putative active site [active]
693979001284	putative metal binding residues [ion binding]; other site
693979001285	signature motif; other site
693979001286	putative dimer interface [polypeptide binding]; other site
693979001287	putative phosphate binding site [ion binding]; other site
693979001288	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
693979001289	Predicted transcriptional regulator [Transcription]; Region: COG2932
693979001290	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
693979001291	Catalytic site [active]
693979001292	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
693979001293	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979001294	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
693979001295	amidase catalytic site [active]
693979001296	Zn binding residues [ion binding]; other site
693979001297	substrate binding site [chemical binding]; other site
693979001298	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979001299	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979001300	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979001301	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979001302	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979001303	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979001304	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979001305	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979001306	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
693979001307	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979001308	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979001309	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
693979001310	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979001311	non-specific DNA binding site [nucleotide binding]; other site
693979001312	salt bridge; other site
693979001313	sequence-specific DNA binding site [nucleotide binding]; other site
693979001314	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
693979001315	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
693979001316	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979001317	Peptidase M15; Region: Peptidase_M15_3; cl01194
693979001318	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
693979001319	peptide chain release factor 2; Validated; Region: prfB; PRK00578
693979001320	PCRF domain; Region: PCRF; pfam03462
693979001321	RF-1 domain; Region: RF-1; pfam00472
693979001322	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
693979001323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
693979001324	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979001325	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979001326	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979001327	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
693979001328	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001329	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001330	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001331	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001332	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979001333	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001334	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979001335	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979001336	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979001337	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979001338	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979001339	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693979001340	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
693979001341	acyl-activating enzyme (AAE) consensus motif; other site
693979001342	putative AMP binding site [chemical binding]; other site
693979001343	putative active site [active]
693979001344	putative CoA binding site [chemical binding]; other site
693979001345	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
693979001346	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
693979001347	metal binding site [ion binding]; metal-binding site
693979001348	dimer interface [polypeptide binding]; other site
693979001349	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001350	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001351	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001352	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979001353	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979001354	SusD family; Region: SusD; pfam07980
693979001355	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979001356	Sulfatase; Region: Sulfatase; cl17466
693979001357	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979001358	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979001359	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001361	ATP binding site [chemical binding]; other site
693979001362	Mg2+ binding site [ion binding]; other site
693979001363	G-X-G motif; other site
693979001364	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
693979001365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979001366	active site
693979001367	phosphorylation site [posttranslational modification]
693979001368	intermolecular recognition site; other site
693979001369	dimerization interface [polypeptide binding]; other site
693979001370	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979001371	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979001372	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
693979001373	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979001374	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
693979001375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001376	binding surface
693979001377	TPR motif; other site
693979001378	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979001379	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979001380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001381	binding surface
693979001382	TPR motif; other site
693979001383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001384	binding surface
693979001385	TPR motif; other site
693979001386	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
693979001387	trimer interface [polypeptide binding]; other site
693979001388	active site
693979001389	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
693979001390	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
693979001391	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
693979001392	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
693979001393	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
693979001394	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
693979001395	putative acyl-acceptor binding pocket; other site
693979001396	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
693979001397	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979001398	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979001399	DNA binding residues [nucleotide binding]
693979001400	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979001401	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
693979001402	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979001403	sugar binding site [chemical binding]; other site
693979001404	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
693979001405	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979001406	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979001407	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979001408	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
693979001409	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979001410	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
693979001411	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979001412	active site
693979001413	Fn3 associated; Region: Fn3_assoc; pfam13287
693979001414	Sulfatase; Region: Sulfatase; cl17466
693979001415	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979001416	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979001417	SusD family; Region: SusD; pfam07980
693979001418	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001419	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001420	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979001421	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001422	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979001423	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979001424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001426	dimer interface [polypeptide binding]; other site
693979001427	phosphorylation site [posttranslational modification]
693979001428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001429	ATP binding site [chemical binding]; other site
693979001430	G-X-G motif; other site
693979001431	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
693979001432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979001433	active site
693979001434	phosphorylation site [posttranslational modification]
693979001435	intermolecular recognition site; other site
693979001436	dimerization interface [polypeptide binding]; other site
693979001437	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
693979001438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979001439	cell division protein MraZ; Reviewed; Region: PRK00326
693979001440	MraZ protein; Region: MraZ; pfam02381
693979001441	MraZ protein; Region: MraZ; pfam02381
693979001442	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
693979001443	MraW methylase family; Region: Methyltransf_5; cl17771
693979001444	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
693979001445	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
693979001446	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
693979001447	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
693979001448	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
693979001449	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693979001450	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979001451	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693979001452	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
693979001453	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
693979001454	Mg++ binding site [ion binding]; other site
693979001455	putative catalytic motif [active]
693979001456	putative substrate binding site [chemical binding]; other site
693979001457	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
693979001458	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979001459	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693979001460	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
693979001461	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
693979001462	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
693979001463	active site
693979001464	homodimer interface [polypeptide binding]; other site
693979001465	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
693979001466	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693979001467	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979001468	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
693979001469	Cell division protein FtsQ; Region: FtsQ; pfam03799
693979001470	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
693979001471	Cell division protein FtsA; Region: FtsA; smart00842
693979001472	Cell division protein FtsA; Region: FtsA; pfam14450
693979001473	cell division protein FtsZ; Validated; Region: PRK09330
693979001474	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
693979001475	nucleotide binding site [chemical binding]; other site
693979001476	SulA interaction site; other site
693979001477	Yqey-like protein; Region: YqeY; pfam09424
693979001478	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
693979001479	Recombination protein O N terminal; Region: RecO_N; pfam11967
693979001480	Recombination protein O C terminal; Region: RecO_C; pfam02565
693979001481	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
693979001482	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
693979001483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001484	ATP binding site [chemical binding]; other site
693979001485	Mg2+ binding site [ion binding]; other site
693979001486	G-X-G motif; other site
693979001487	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
693979001488	anchoring element; other site
693979001489	dimer interface [polypeptide binding]; other site
693979001490	ATP binding site [chemical binding]; other site
693979001491	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
693979001492	active site
693979001493	putative metal-binding site [ion binding]; other site
693979001494	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
693979001495	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
693979001496	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979001497	phosphoglyceromutase; Provisional; Region: PRK05434
693979001498	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
693979001499	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
693979001500	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
693979001501	Cl binding site [ion binding]; other site
693979001502	oligomer interface [polypeptide binding]; other site
693979001503	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
693979001504	RNA/DNA hybrid binding site [nucleotide binding]; other site
693979001505	active site
693979001506	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979001507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001508	TPR motif; other site
693979001509	binding surface
693979001510	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979001511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
693979001512	binding surface
693979001513	TPR motif; other site
693979001514	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979001515	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001516	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001517	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001518	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979001519	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001520	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979001521	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
693979001522	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
693979001523	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979001524	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979001525	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979001526	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
693979001527	alpha-glucosidase; Provisional; Region: PRK10137
693979001528	Trehalase; Region: Trehalase; cl17346
693979001529	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
693979001530	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
693979001531	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
693979001532	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
693979001533	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979001534	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
693979001535	putative ligand binding site [chemical binding]; other site
693979001536	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001537	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001538	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001539	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979001540	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001541	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
693979001542	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979001543	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979001544	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979001545	DNA binding residues [nucleotide binding]
693979001546	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
693979001547	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
693979001548	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693979001549	catalytic residue [active]
693979001550	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
693979001551	FeS assembly protein SufD; Region: sufD; TIGR01981
693979001552	FeS assembly ATPase SufC; Region: sufC; TIGR01978
693979001553	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
693979001554	Walker A/P-loop; other site
693979001555	ATP binding site [chemical binding]; other site
693979001556	Q-loop/lid; other site
693979001557	ABC transporter signature motif; other site
693979001558	Walker B; other site
693979001559	D-loop; other site
693979001560	H-loop/switch region; other site
693979001561	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
693979001562	putative ABC transporter; Region: ycf24; CHL00085
693979001563	Colicin V production protein; Region: Colicin_V; pfam02674
693979001564	translation initiation factor IF-2; Region: IF-2; TIGR00487
693979001565	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
693979001566	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
693979001567	G1 box; other site
693979001568	putative GEF interaction site [polypeptide binding]; other site
693979001569	GTP/Mg2+ binding site [chemical binding]; other site
693979001570	Switch I region; other site
693979001571	G2 box; other site
693979001572	G3 box; other site
693979001573	Switch II region; other site
693979001574	G4 box; other site
693979001575	G5 box; other site
693979001576	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
693979001577	Translation-initiation factor 2; Region: IF-2; pfam11987
693979001578	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
693979001579	transcription termination factor NusA; Region: NusA; TIGR01953
693979001580	NusA N-terminal domain; Region: NusA_N; pfam08529
693979001581	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
693979001582	RNA binding site [nucleotide binding]; other site
693979001583	homodimer interface [polypeptide binding]; other site
693979001584	NusA-like KH domain; Region: KH_5; pfam13184
693979001585	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
693979001586	G-X-X-G motif; other site
693979001587	hypothetical protein; Validated; Region: PRK02001
693979001588	heptamer interface [polypeptide binding]; other site
693979001589	Sm1 motif; other site
693979001590	hexamer interface [polypeptide binding]; other site
693979001591	RNA binding site [nucleotide binding]; other site
693979001592	Sm2 motif; other site
693979001593	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
693979001594	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979001595	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979001596	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979001597	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
693979001598	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
693979001599	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
693979001600	Protein of unknown function DUF45; Region: DUF45; pfam01863
693979001601	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
693979001602	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
693979001603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979001604	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979001605	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979001606	DNA binding residues [nucleotide binding]
693979001607	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
693979001608	nucleotide binding site [chemical binding]; other site
693979001609	N-acetyl-L-glutamate binding site [chemical binding]; other site
693979001610	arginine decarboxylase; Provisional; Region: PRK05354
693979001611	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
693979001612	dimer interface [polypeptide binding]; other site
693979001613	active site
693979001614	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693979001615	catalytic residues [active]
693979001616	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
693979001617	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
693979001618	Shikimate kinase; Region: SKI; pfam01202
693979001619	ADP binding site [chemical binding]; other site
693979001620	magnesium binding site [ion binding]; other site
693979001621	putative shikimate binding site; other site
693979001622	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
693979001623	dimer interface [polypeptide binding]; other site
693979001624	FMN binding site [chemical binding]; other site
693979001625	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001626	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001627	SusD family; Region: SusD; pfam07980
693979001628	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001629	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001630	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001631	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
693979001632	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
693979001633	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
693979001634	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
693979001635	active site
693979001636	RNA/DNA hybrid binding site [nucleotide binding]; other site
693979001637	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
693979001638	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
693979001639	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
693979001640	Walker A/P-loop; other site
693979001641	ATP binding site [chemical binding]; other site
693979001642	Q-loop/lid; other site
693979001643	ABC transporter signature motif; other site
693979001644	Walker B; other site
693979001645	D-loop; other site
693979001646	H-loop/switch region; other site
693979001647	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
693979001648	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
693979001649	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
693979001650	Walker A/P-loop; other site
693979001651	ATP binding site [chemical binding]; other site
693979001652	Q-loop/lid; other site
693979001653	ABC transporter signature motif; other site
693979001654	Walker B; other site
693979001655	D-loop; other site
693979001656	H-loop/switch region; other site
693979001657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979001658	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
693979001659	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979001660	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979001661	active site
693979001662	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
693979001663	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
693979001664	Sulfatase; Region: Sulfatase; cl17466
693979001665	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
693979001666	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979001667	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
693979001668	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979001669	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
693979001670	putative metal binding site; other site
693979001671	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
693979001672	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979001673	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
693979001674	Substrate binding site; other site
693979001675	metal-binding site
693979001676	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
693979001677	GDP-Fucose binding site [chemical binding]; other site
693979001678	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979001679	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979001680	active site
693979001681	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
693979001682	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
693979001683	putative acyl-acceptor binding pocket; other site
693979001684	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
693979001685	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
693979001686	putative active site [active]
693979001687	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
693979001688	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
693979001689	ligand binding site [chemical binding]; other site
693979001690	NAD binding site [chemical binding]; other site
693979001691	catalytic site [active]
693979001692	homodimer interface [polypeptide binding]; other site
693979001693	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
693979001694	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
693979001695	active site
693979001696	substrate binding site [chemical binding]; other site
693979001697	cosubstrate binding site; other site
693979001698	catalytic site [active]
693979001699	acyl carrier protein; Provisional; Region: acpP; PRK00982
693979001700	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
693979001701	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
693979001702	dimer interface [polypeptide binding]; other site
693979001703	active site
693979001704	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
693979001705	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
693979001706	dimerization interface [polypeptide binding]; other site
693979001707	active site
693979001708	metal binding site [ion binding]; metal-binding site
693979001709	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
693979001710	dsRNA binding site [nucleotide binding]; other site
693979001711	6-phosphofructokinase; Provisional; Region: PRK03202
693979001712	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
693979001713	active site
693979001714	ADP/pyrophosphate binding site [chemical binding]; other site
693979001715	dimerization interface [polypeptide binding]; other site
693979001716	allosteric effector site; other site
693979001717	fructose-1,6-bisphosphate binding site; other site
693979001718	GH3 auxin-responsive promoter; Region: GH3; pfam03321
693979001719	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665
693979001720	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
693979001721	Ligand Binding Site [chemical binding]; other site
693979001722	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979001723	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
693979001724	active site
693979001725	motif I; other site
693979001726	motif II; other site
693979001727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979001728	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
693979001729	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
693979001730	active site
693979001731	HIGH motif; other site
693979001732	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
693979001733	KMSKS motif; other site
693979001734	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
693979001735	tRNA binding surface [nucleotide binding]; other site
693979001736	anticodon binding site; other site
693979001737	Sulfatase; Region: Sulfatase; cl17466
693979001738	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979001739	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
693979001740	Bacterial Ig-like domain; Region: Big_5; pfam13205
693979001741	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
693979001742	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
693979001743	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979001744	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979001745	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979001746	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979001747	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693979001748	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
693979001749	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
693979001750	active site
693979001751	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
693979001752	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
693979001753	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
693979001754	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
693979001755	putative ligand binding site [chemical binding]; other site
693979001756	Phosphotransferase enzyme family; Region: APH; pfam01636
693979001757	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979001758	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979001759	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001760	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001761	dimer interface [polypeptide binding]; other site
693979001762	phosphorylation site [posttranslational modification]
693979001763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001764	ATP binding site [chemical binding]; other site
693979001765	Mg2+ binding site [ion binding]; other site
693979001766	G-X-G motif; other site
693979001767	Response regulator receiver domain; Region: Response_reg; pfam00072
693979001768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979001769	active site
693979001770	phosphorylation site [posttranslational modification]
693979001771	intermolecular recognition site; other site
693979001772	dimerization interface [polypeptide binding]; other site
693979001773	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
693979001774	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979001775	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979001776	Sulfatase; Region: Sulfatase; pfam00884
693979001777	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001778	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001779	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001780	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001781	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001782	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979001783	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001784	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001785	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001786	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001787	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001788	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979001789	SusD family; Region: SusD; pfam07980
693979001790	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706
693979001791	substrate binding site [chemical binding]; other site
693979001792	catalytic residues [active]
693979001793	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
693979001794	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
693979001795	FMN binding site [chemical binding]; other site
693979001796	active site
693979001797	catalytic residues [active]
693979001798	substrate binding site [chemical binding]; other site
693979001799	Lyase, N terminal; Region: Lyase_N; pfam09092
693979001800	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706
693979001801	substrate binding site [chemical binding]; other site
693979001802	catalytic residues [active]
693979001803	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
693979001804	dihydrodipicolinate reductase; Provisional; Region: PRK00048
693979001805	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
693979001806	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
693979001807	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
693979001808	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693979001809	signal peptidase I; Provisional; Region: PRK10861
693979001810	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693979001811	Catalytic site [active]
693979001812	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693979001813	WbqC-like protein family; Region: WbqC; pfam08889
693979001814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001816	dimer interface [polypeptide binding]; other site
693979001817	phosphorylation site [posttranslational modification]
693979001818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001819	ATP binding site [chemical binding]; other site
693979001820	Mg2+ binding site [ion binding]; other site
693979001821	G-X-G motif; other site
693979001822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001824	dimer interface [polypeptide binding]; other site
693979001825	phosphorylation site [posttranslational modification]
693979001826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001827	ATP binding site [chemical binding]; other site
693979001828	Mg2+ binding site [ion binding]; other site
693979001829	G-X-G motif; other site
693979001830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001832	dimer interface [polypeptide binding]; other site
693979001833	phosphorylation site [posttranslational modification]
693979001834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001835	ATP binding site [chemical binding]; other site
693979001836	Mg2+ binding site [ion binding]; other site
693979001837	G-X-G motif; other site
693979001838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979001839	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979001840	dimer interface [polypeptide binding]; other site
693979001841	phosphorylation site [posttranslational modification]
693979001842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979001843	ATP binding site [chemical binding]; other site
693979001844	Mg2+ binding site [ion binding]; other site
693979001845	G-X-G motif; other site
693979001846	ribonuclease Y; Region: RNase_Y; TIGR03319
693979001847	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001848	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001849	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001850	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979001851	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001852	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001853	SusD family; Region: SusD; pfam07980
693979001854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
693979001855	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001856	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001857	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001858	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979001859	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979001860	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979001861	beta-D-glucuronidase; Provisional; Region: PRK10150
693979001862	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979001863	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979001864	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
693979001865	Alginate lyase; Region: Alginate_lyase; pfam05426
693979001866	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
693979001867	beta-D-glucuronidase; Provisional; Region: PRK10150
693979001868	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979001869	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979001870	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979001871	D-mannonate oxidoreductase; Provisional; Region: PRK08277
693979001872	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979001873	NAD(P) binding site [chemical binding]; other site
693979001874	active site
693979001875	mannonate dehydratase; Provisional; Region: PRK03906
693979001876	mannonate dehydratase; Region: uxuA; TIGR00695
693979001877	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
693979001878	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
693979001879	amphipathic channel; other site
693979001880	Asn-Pro-Ala signature motifs; other site
693979001881	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979001882	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979001883	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979001884	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
693979001885	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
693979001886	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
693979001887	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
693979001888	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979001889	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979001890	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979001891	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
693979001892	putative active site [active]
693979001893	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693979001894	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
693979001895	putative substrate binding site [chemical binding]; other site
693979001896	putative ATP binding site [chemical binding]; other site
693979001897	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
693979001898	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
693979001899	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
693979001900	helicase 45; Provisional; Region: PTZ00424
693979001901	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693979001902	ATP binding site [chemical binding]; other site
693979001903	Mg++ binding site [ion binding]; other site
693979001904	motif III; other site
693979001905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979001906	nucleotide binding region [chemical binding]; other site
693979001907	ATP-binding site [chemical binding]; other site
693979001908	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
693979001909	RNA binding site [nucleotide binding]; other site
693979001910	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
693979001911	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
693979001912	dimerization interface [polypeptide binding]; other site
693979001913	DPS ferroxidase diiron center [ion binding]; other site
693979001914	ion pore; other site
693979001915	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
693979001916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
693979001917	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
693979001918	dimerization interface [polypeptide binding]; other site
693979001919	peroxiredoxin; Region: AhpC; TIGR03137
693979001920	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
693979001921	dimer interface [polypeptide binding]; other site
693979001922	decamer (pentamer of dimers) interface [polypeptide binding]; other site
693979001923	catalytic triad [active]
693979001924	peroxidatic and resolving cysteines [active]
693979001925	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
693979001926	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
693979001927	catalytic residue [active]
693979001928	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
693979001929	catalytic residues [active]
693979001930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
693979001931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979001932	Peptidase S46; Region: Peptidase_S46; pfam10459
693979001933	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
693979001934	Domain of unknown function (DUF389); Region: DUF389; pfam04087
693979001935	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979001936	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
693979001937	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
693979001938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979001939	Walker A motif; other site
693979001940	ATP binding site [chemical binding]; other site
693979001941	Walker B motif; other site
693979001942	arginine finger; other site
693979001943	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
693979001944	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
693979001945	Sel1-like repeats; Region: SEL1; smart00671
693979001946	Sel1-like repeats; Region: SEL1; smart00671
693979001947	Sel1 repeat; Region: Sel1; cl02723
693979001948	Gram-negative bacterial tonB protein; Region: TonB; cl10048
693979001949	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
693979001950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979001951	TPR motif; other site
693979001952	binding surface
693979001953	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979001954	KWG Leptospira; Region: KWG; pfam07656
693979001955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979001956	AAA domain; Region: AAA_21; pfam13304
693979001957	Walker A/P-loop; other site
693979001958	ATP binding site [chemical binding]; other site
693979001959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979001960	ABC transporter signature motif; other site
693979001961	Walker B; other site
693979001962	D-loop; other site
693979001963	H-loop/switch region; other site
693979001964	CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116
693979001965	CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119
693979001966	radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115
693979001967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979001968	FeS/SAM binding site; other site
693979001969	CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119
693979001970	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
693979001971	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
693979001972	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
693979001973	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
693979001974	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
693979001975	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
693979001976	A new structural DNA glycosylase; Region: AlkD_like; cd06561
693979001977	active site
693979001978	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
693979001979	Peptidase family M28; Region: Peptidase_M28; pfam04389
693979001980	metal binding site [ion binding]; metal-binding site
693979001981	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
693979001982	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
693979001983	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
693979001984	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
693979001985	active site
693979001986	catalytic residues [active]
693979001987	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
693979001988	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
693979001989	putative substrate binding site [chemical binding]; other site
693979001990	active site
693979001991	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
693979001992	active site
693979001993	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979001994	SusD family; Region: SusD; pfam07980
693979001995	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979001996	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979001997	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979001998	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979001999	Two component regulator propeller; Region: Reg_prop; pfam07494
693979002000	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979002001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979002002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979002003	dimer interface [polypeptide binding]; other site
693979002004	phosphorylation site [posttranslational modification]
693979002005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002006	ATP binding site [chemical binding]; other site
693979002007	Mg2+ binding site [ion binding]; other site
693979002008	G-X-G motif; other site
693979002009	Response regulator receiver domain; Region: Response_reg; pfam00072
693979002010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979002011	active site
693979002012	phosphorylation site [posttranslational modification]
693979002013	intermolecular recognition site; other site
693979002014	dimerization interface [polypeptide binding]; other site
693979002015	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979002016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002017	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979002018	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979002019	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979002020	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
693979002021	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
693979002022	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
693979002023	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979002024	active site
693979002025	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
693979002026	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
693979002027	GIY-YIG motif/motif A; other site
693979002028	active site
693979002029	catalytic site [active]
693979002030	putative DNA binding site [nucleotide binding]; other site
693979002031	metal binding site [ion binding]; metal-binding site
693979002032	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
693979002033	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
693979002034	DNA binding site [nucleotide binding]
693979002035	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
693979002036	putative active site [active]
693979002037	dimerization interface [polypeptide binding]; other site
693979002038	putative tRNAtyr binding site [nucleotide binding]; other site
693979002039	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
693979002040	homodimer interface [polypeptide binding]; other site
693979002041	metal binding site [ion binding]; metal-binding site
693979002042	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
693979002043	intersubunit interface [polypeptide binding]; other site
693979002044	active site
693979002045	catalytic residue [active]
693979002046	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
693979002047	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
693979002048	substrate binding pocket [chemical binding]; other site
693979002049	chain length determination region; other site
693979002050	substrate-Mg2+ binding site; other site
693979002051	catalytic residues [active]
693979002052	aspartate-rich region 1; other site
693979002053	active site lid residues [active]
693979002054	aspartate-rich region 2; other site
693979002055	DNA polymerase I; Region: pola; TIGR00593
693979002056	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
693979002057	active site
693979002058	metal binding site 1 [ion binding]; metal-binding site
693979002059	putative 5' ssDNA interaction site; other site
693979002060	metal binding site 3; metal-binding site
693979002061	metal binding site 2 [ion binding]; metal-binding site
693979002062	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
693979002063	putative DNA binding site [nucleotide binding]; other site
693979002064	putative metal binding site [ion binding]; other site
693979002065	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
693979002066	active site
693979002067	catalytic site [active]
693979002068	substrate binding site [chemical binding]; other site
693979002069	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
693979002070	active site
693979002071	DNA binding site [nucleotide binding]
693979002072	catalytic site [active]
693979002073	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
693979002074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
693979002075	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
693979002076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979002077	Walker A/P-loop; other site
693979002078	ATP binding site [chemical binding]; other site
693979002079	Q-loop/lid; other site
693979002080	ABC transporter signature motif; other site
693979002081	Walker B; other site
693979002082	D-loop; other site
693979002083	H-loop/switch region; other site
693979002084	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
693979002085	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
693979002086	GTP-binding protein YchF; Reviewed; Region: PRK09601
693979002087	YchF GTPase; Region: YchF; cd01900
693979002088	G1 box; other site
693979002089	GTP/Mg2+ binding site [chemical binding]; other site
693979002090	Switch I region; other site
693979002091	G2 box; other site
693979002092	Switch II region; other site
693979002093	G3 box; other site
693979002094	G4 box; other site
693979002095	G5 box; other site
693979002096	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
693979002097	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
693979002098	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
693979002099	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
693979002100	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
693979002101	ORF6N domain; Region: ORF6N; pfam10543
693979002102	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
693979002103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979002104	motif II; other site
693979002105	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
693979002106	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979002107	LytTr DNA-binding domain; Region: LytTR; smart00850
693979002108	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
693979002109	MutS domain I; Region: MutS_I; pfam01624
693979002110	MutS domain II; Region: MutS_II; pfam05188
693979002111	MutS domain III; Region: MutS_III; pfam05192
693979002112	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
693979002113	Walker A/P-loop; other site
693979002114	ATP binding site [chemical binding]; other site
693979002115	Q-loop/lid; other site
693979002116	ABC transporter signature motif; other site
693979002117	Walker B; other site
693979002118	D-loop; other site
693979002119	H-loop/switch region; other site
693979002120	Cupin domain; Region: Cupin_2; pfam07883
693979002121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002122	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979002123	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002124	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
693979002125	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
693979002126	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693979002127	active site
693979002128	metal binding site [ion binding]; metal-binding site
693979002129	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979002130	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979002131	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979002132	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979002133	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979002134	Caspase domain; Region: Peptidase_C14; pfam00656
693979002135	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
693979002136	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
693979002137	dihydroorotase; Validated; Region: PRK09059
693979002138	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979002139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002140	Nitroreductase family; Region: Nitroreductase; pfam00881
693979002141	FMN binding site [chemical binding]; other site
693979002142	dimer interface [polypeptide binding]; other site
693979002143	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979002144	Predicted transcriptional regulators [Transcription]; Region: COG1733
693979002145	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
693979002146	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
693979002147	EamA-like transporter family; Region: EamA; pfam00892
693979002148	EamA-like transporter family; Region: EamA; pfam00892
693979002149	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
693979002150	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002151	active site
693979002152	HIGH motif; other site
693979002153	nucleotide binding site [chemical binding]; other site
693979002154	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002155	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
693979002156	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002157	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002158	active site
693979002159	KMSKS motif; other site
693979002160	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
693979002161	tRNA binding surface [nucleotide binding]; other site
693979002162	Uncharacterized conserved protein [Function unknown]; Region: COG1284
693979002163	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
693979002164	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
693979002165	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
693979002166	active site
693979002167	dimerization interface [polypeptide binding]; other site
693979002168	quinolinate synthetase; Provisional; Region: PRK09375
693979002169	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693979002170	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
693979002171	Uncharacterized conserved protein [Function unknown]; Region: COG1284
693979002172	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
693979002173	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
693979002174	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
693979002175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979002176	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979002177	dimer interface [polypeptide binding]; other site
693979002178	phosphorylation site [posttranslational modification]
693979002179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002180	ATP binding site [chemical binding]; other site
693979002181	Mg2+ binding site [ion binding]; other site
693979002182	G-X-G motif; other site
693979002183	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
693979002184	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
693979002185	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979002186	FeS/SAM binding site; other site
693979002187	Radical SAM superfamily; Region: Radical_SAM; pfam04055
693979002188	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
693979002189	catalytic motif [active]
693979002190	Catalytic residue [active]
693979002191	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
693979002192	protein binding site [polypeptide binding]; other site
693979002193	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
693979002194	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
693979002195	active site
693979002196	substrate binding site [chemical binding]; other site
693979002197	Mg2+ binding site [ion binding]; other site
693979002198	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
693979002199	putative transporter; Provisional; Region: PRK11660
693979002200	Sulfate transporter family; Region: Sulfate_transp; pfam00916
693979002201	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
693979002202	Rubrerythrin [Energy production and conversion]; Region: COG1592
693979002203	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
693979002204	binuclear metal center [ion binding]; other site
693979002205	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
693979002206	iron binding site [ion binding]; other site
693979002207	Cupin domain; Region: Cupin_2; cl17218
693979002208	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
693979002209	active site
693979002210	catalytic residues [active]
693979002211	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979002212	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
693979002213	OmpA family; Region: OmpA; pfam00691
693979002214	ligand binding site [chemical binding]; other site
693979002215	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979002216	L-aspartate oxidase; Provisional; Region: PRK09077
693979002217	L-aspartate oxidase; Provisional; Region: PRK06175
693979002218	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
693979002219	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
693979002220	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979002221	LytTr DNA-binding domain; Region: LytTR; smart00850
693979002222	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
693979002223	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
693979002224	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
693979002225	NVEALA protein; Region: NVEALA; pfam14055
693979002226	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
693979002227	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
693979002228	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979002229	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693979002230	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
693979002231	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
693979002232	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979002233	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002234	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979002235	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979002236	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979002237	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979002238	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693979002239	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
693979002240	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
693979002241	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
693979002242	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
693979002243	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693979002244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979002245	FeS/SAM binding site; other site
693979002246	TRAM domain; Region: TRAM; pfam01938
693979002247	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979002248	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979002249	Active site serine [active]
693979002250	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
693979002251	Methyltransferase domain; Region: Methyltransf_23; pfam13489
693979002252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979002253	S-adenosylmethionine binding site [chemical binding]; other site
693979002254	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
693979002255	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
693979002256	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
693979002257	Bacitracin resistance protein BacA; Region: BacA; pfam02673
693979002258	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
693979002259	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
693979002260	RNA binding site [nucleotide binding]; other site
693979002261	active site
693979002262	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
693979002263	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
693979002264	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
693979002265	catalytic center binding site [active]
693979002266	ATP binding site [chemical binding]; other site
693979002267	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
693979002268	putative catalytic site [active]
693979002269	putative metal binding site [ion binding]; other site
693979002270	putative phosphate binding site [ion binding]; other site
693979002271	S-adenosylmethionine synthetase; Validated; Region: PRK05250
693979002272	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
693979002273	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
693979002274	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
693979002275	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
693979002276	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
693979002277	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
693979002278	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
693979002279	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
693979002280	active site
693979002281	ribonuclease P; Reviewed; Region: rnpA; PRK01903
693979002282	Haemolytic domain; Region: Haemolytic; pfam01809
693979002283	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
693979002284	active site
693979002285	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
693979002286	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
693979002287	active site
693979002288	HIGH motif; other site
693979002289	dimer interface [polypeptide binding]; other site
693979002290	KMSKS motif; other site
693979002291	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
693979002292	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
693979002293	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
693979002294	NADP binding site [chemical binding]; other site
693979002295	homodimer interface [polypeptide binding]; other site
693979002296	active site
693979002297	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
693979002298	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
693979002299	NodB motif; other site
693979002300	active site
693979002301	catalytic site [active]
693979002302	metal binding site [ion binding]; metal-binding site
693979002303	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
693979002304	alpha-galactosidase; Region: PLN02808; cl17638
693979002305	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
693979002306	Ca binding site [ion binding]; other site
693979002307	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
693979002308	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
693979002309	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
693979002310	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
693979002311	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
693979002312	putative metal binding residues [ion binding]; other site
693979002313	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
693979002314	Predicted membrane protein [Function unknown]; Region: COG1238
693979002315	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
693979002316	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
693979002317	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
693979002318	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
693979002319	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
693979002320	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
693979002321	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
693979002322	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
693979002323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
693979002324	serine O-acetyltransferase; Region: cysE; TIGR01172
693979002325	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
693979002326	trimer interface [polypeptide binding]; other site
693979002327	active site
693979002328	substrate binding site [chemical binding]; other site
693979002329	CoA binding site [chemical binding]; other site
693979002330	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
693979002331	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
693979002332	dimer interface [polypeptide binding]; other site
693979002333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979002334	catalytic residue [active]
693979002335	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
693979002336	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979002337	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979002338	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979002339	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
693979002340	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979002341	sugar binding site [chemical binding]; other site
693979002342	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979002343	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979002344	SusD family; Region: SusD; pfam07980
693979002345	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979002346	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979002347	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979002348	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979002349	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979002350	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979002351	FecR protein; Region: FecR; pfam04773
693979002352	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979002353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979002354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979002355	DNA binding residues [nucleotide binding]
693979002356	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
693979002357	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979002358	ribonuclease R; Region: RNase_R; TIGR02063
693979002359	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693979002360	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693979002361	RNB domain; Region: RNB; pfam00773
693979002362	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
693979002363	RNA binding site [nucleotide binding]; other site
693979002364	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
693979002365	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
693979002366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979002367	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979002368	NAD(P) binding site [chemical binding]; other site
693979002369	active site
693979002370	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
693979002371	active site
693979002372	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
693979002373	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
693979002374	FMN binding site [chemical binding]; other site
693979002375	active site
693979002376	catalytic residues [active]
693979002377	substrate binding site [chemical binding]; other site
693979002378	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
693979002379	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
693979002380	Peptidase family U32; Region: Peptidase_U32; pfam01136
693979002381	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
693979002382	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693979002383	active site
693979002384	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
693979002385	DNA protecting protein DprA; Region: dprA; TIGR00732
693979002386	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
693979002387	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
693979002388	putative active site [active]
693979002389	catalytic site [active]
693979002390	putative metal binding site [ion binding]; other site
693979002391	oligomer interface [polypeptide binding]; other site
693979002392	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979002393	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
693979002394	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
693979002395	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979002396	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
693979002397	L-aspartate oxidase; Provisional; Region: PRK06175
693979002398	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
693979002399	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
693979002400	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
693979002401	putative Iron-sulfur protein interface [polypeptide binding]; other site
693979002402	proximal heme binding site [chemical binding]; other site
693979002403	distal heme binding site [chemical binding]; other site
693979002404	putative dimer interface [polypeptide binding]; other site
693979002405	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979002406	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
693979002407	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979002408	active site
693979002409	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693979002410	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979002411	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979002412	catalytic residues [active]
693979002413	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
693979002414	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693979002415	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979002416	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693979002417	protein binding site [polypeptide binding]; other site
693979002418	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
693979002419	Catalytic dyad [active]
693979002420	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
693979002421	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002422	active site
693979002423	nucleotide binding site [chemical binding]; other site
693979002424	HIGH motif; other site
693979002425	KMSKS motif; other site
693979002426	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
693979002427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002428	ATP binding site [chemical binding]; other site
693979002429	Mg2+ binding site [ion binding]; other site
693979002430	G-X-G motif; other site
693979002431	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
693979002432	ATP binding site [chemical binding]; other site
693979002433	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
693979002434	active site
693979002435	putative metal-binding site [ion binding]; other site
693979002436	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
693979002437	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
693979002438	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
693979002439	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
693979002440	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
693979002441	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693979002442	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
693979002443	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979002444	active site
693979002445	metal binding site [ion binding]; metal-binding site
693979002446	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
693979002447	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
693979002448	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979002449	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979002450	Sulfatase; Region: Sulfatase; cl17466
693979002451	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979002452	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979002453	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
693979002454	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979002455	Sulfatase; Region: Sulfatase; pfam00884
693979002456	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
693979002457	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
693979002458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
693979002459	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
693979002460	Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1
693979002461	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979002462	active site
693979002463	DNA binding site [nucleotide binding]
693979002464	Int/Topo IB signature motif; other site
693979002465	ScaI restriction endonuclease; Region: RE_ScaI; pfam09569
693979002466	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
693979002467	DNA methylase; Region: N6_N4_Mtase; pfam01555
693979002468	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
693979002469	DGQHR domain; Region: DGQHR; TIGR03187
693979002470	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979002471	active site
693979002472	DNA binding site [nucleotide binding]
693979002473	Int/Topo IB signature motif; other site
693979002474	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
693979002475	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
693979002476	putative DNA binding site [nucleotide binding]; other site
693979002477	putative Zn2+ binding site [ion binding]; other site
693979002478	AsnC family; Region: AsnC_trans_reg; pfam01037
693979002479	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
693979002480	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
693979002481	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
693979002482	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
693979002483	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
693979002484	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
693979002485	NAD-dependent deacetylase; Provisional; Region: PRK00481
693979002486	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
693979002487	NAD+ binding site [chemical binding]; other site
693979002488	substrate binding site [chemical binding]; other site
693979002489	Zn binding site [ion binding]; other site
693979002490	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
693979002491	metal-binding site
693979002492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979002493	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
693979002494	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
693979002495	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
693979002496	NAD(P) binding site [chemical binding]; other site
693979002497	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693979002498	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
693979002499	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
693979002500	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
693979002501	active site
693979002502	homodimer interface [polypeptide binding]; other site
693979002503	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979002504	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
693979002505	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979002506	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979002507	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
693979002508	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
693979002509	Core-2/I-Branching enzyme; Region: Branch; pfam02485
693979002510	colanic acid exporter; Provisional; Region: PRK10459
693979002511	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
693979002512	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
693979002513	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
693979002514	active site
693979002515	HIGH motif; other site
693979002516	KMSKS motif; other site
693979002517	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
693979002518	tRNA binding surface [nucleotide binding]; other site
693979002519	anticodon binding site; other site
693979002520	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
693979002521	dimer interface [polypeptide binding]; other site
693979002522	putative tRNA-binding site [nucleotide binding]; other site
693979002523	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979002524	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979002525	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979002526	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979002527	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
693979002528	CoA binding domain; Region: CoA_binding_2; pfam13380
693979002529	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
693979002530	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
693979002531	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
693979002532	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
693979002533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979002534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
693979002535	Walker A motif; other site
693979002536	ATP binding site [chemical binding]; other site
693979002537	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
693979002538	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979002539	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979002540	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979002541	catalytic residues [active]
693979002542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979002543	TPR motif; other site
693979002544	TPR repeat; Region: TPR_11; pfam13414
693979002545	binding surface
693979002546	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
693979002547	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
693979002548	active site
693979002549	Int/Topo IB signature motif; other site
693979002550	Dehydroquinase class II; Region: DHquinase_II; pfam01220
693979002551	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
693979002552	trimer interface [polypeptide binding]; other site
693979002553	active site
693979002554	dimer interface [polypeptide binding]; other site
693979002555	pyruvate kinase; Provisional; Region: PRK05826
693979002556	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
693979002557	domain interfaces; other site
693979002558	active site
693979002559	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
693979002560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979002561	S-adenosylmethionine binding site [chemical binding]; other site
693979002562	Outer membrane efflux protein; Region: OEP; pfam02321
693979002563	Outer membrane efflux protein; Region: OEP; pfam02321
693979002564	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
693979002565	Protein export membrane protein; Region: SecD_SecF; cl14618
693979002566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979002567	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
693979002568	E3 interaction surface; other site
693979002569	lipoyl attachment site [posttranslational modification]; other site
693979002570	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979002571	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979002572	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
693979002573	active site
693979002574	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
693979002575	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
693979002576	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
693979002577	metal binding site 2 [ion binding]; metal-binding site
693979002578	putative DNA binding helix; other site
693979002579	metal binding site 1 [ion binding]; metal-binding site
693979002580	dimer interface [polypeptide binding]; other site
693979002581	structural Zn2+ binding site [ion binding]; other site
693979002582	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979002583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002584	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
693979002585	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693979002586	catalytic site [active]
693979002587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979002588	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979002589	putative substrate translocation pore; other site
693979002590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979002591	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979002592	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
693979002593	active site
693979002594	catalytic tetrad [active]
693979002595	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
693979002596	active site
693979002597	Mn binding site [ion binding]; other site
693979002598	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
693979002599	FMN binding site [chemical binding]; other site
693979002600	dimer interface [polypeptide binding]; other site
693979002601	Predicted transcriptional regulators [Transcription]; Region: COG1733
693979002602	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
693979002603	potential frameshift: common BLAST hit: gi|150004999|ref|YP_001299743.1| mobilization protein
693979002604	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
693979002605	Ribosome-binding factor A; Region: RBFA; pfam02033
693979002606	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
693979002607	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979002608	FtsX-like permease family; Region: FtsX; pfam02687
693979002609	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
693979002610	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
693979002611	S-ribosylhomocysteinase; Provisional; Region: PRK02260
693979002612	AMP-binding domain protein; Validated; Region: PRK08315
693979002613	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979002614	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
693979002615	acyl-activating enzyme (AAE) consensus motif; other site
693979002616	putative AMP binding site [chemical binding]; other site
693979002617	putative active site [active]
693979002618	putative CoA binding site [chemical binding]; other site
693979002619	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
693979002620	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979002621	non-specific DNA binding site [nucleotide binding]; other site
693979002622	salt bridge; other site
693979002623	sequence-specific DNA binding site [nucleotide binding]; other site
693979002624	Cupin domain; Region: Cupin_2; pfam07883
693979002625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979002626	non-specific DNA binding site [nucleotide binding]; other site
693979002627	salt bridge; other site
693979002628	sequence-specific DNA binding site [nucleotide binding]; other site
693979002629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979002630	non-specific DNA binding site [nucleotide binding]; other site
693979002631	salt bridge; other site
693979002632	sequence-specific DNA binding site [nucleotide binding]; other site
693979002633	HipA N-terminal domain; Region: couple_hipA; TIGR03071
693979002634	HipA-like N-terminal domain; Region: HipA_N; pfam07805
693979002635	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
693979002636	HipA-like C-terminal domain; Region: HipA_C; pfam07804
693979002637	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
693979002638	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
693979002639	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
693979002640	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
693979002641	16S/18S rRNA binding site [nucleotide binding]; other site
693979002642	S13e-L30e interaction site [polypeptide binding]; other site
693979002643	25S rRNA binding site [nucleotide binding]; other site
693979002644	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
693979002645	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
693979002646	G1 box; other site
693979002647	putative GEF interaction site [polypeptide binding]; other site
693979002648	GTP/Mg2+ binding site [chemical binding]; other site
693979002649	Switch I region; other site
693979002650	G2 box; other site
693979002651	G3 box; other site
693979002652	Switch II region; other site
693979002653	G4 box; other site
693979002654	G5 box; other site
693979002655	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
693979002656	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
693979002657	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979002658	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979002659	Peptidase M60-like family; Region: M60-like; pfam13402
693979002660	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
693979002661	putative FMN binding site [chemical binding]; other site
693979002662	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
693979002663	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
693979002664	active site
693979002665	substrate-binding site [chemical binding]; other site
693979002666	metal-binding site [ion binding]
693979002667	ATP binding site [chemical binding]; other site
693979002668	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979002669	active site
693979002670	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
693979002671	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
693979002672	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979002673	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
693979002674	acyl-activating enzyme (AAE) consensus motif; other site
693979002675	AMP binding site [chemical binding]; other site
693979002676	active site
693979002677	CoA binding site [chemical binding]; other site
693979002678	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
693979002679	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
693979002680	TPP-binding site [chemical binding]; other site
693979002681	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
693979002682	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
693979002683	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
693979002684	dimer interface [polypeptide binding]; other site
693979002685	PYR/PP interface [polypeptide binding]; other site
693979002686	TPP binding site [chemical binding]; other site
693979002687	substrate binding site [chemical binding]; other site
693979002688	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
693979002689	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
693979002690	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
693979002691	Protein export membrane protein; Region: SecD_SecF; pfam02355
693979002692	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
693979002693	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
693979002694	active site
693979002695	Zn binding site [ion binding]; other site
693979002696	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
693979002697	putative catalytic site [active]
693979002698	putative metal binding site [ion binding]; other site
693979002699	putative phosphate binding site [ion binding]; other site
693979002700	Rhomboid family; Region: Rhomboid; pfam01694
693979002701	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
693979002702	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
693979002703	IHF - DNA interface [nucleotide binding]; other site
693979002704	IHF dimer interface [polypeptide binding]; other site
693979002705	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
693979002706	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
693979002707	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979002708	active site
693979002709	HIGH motif; other site
693979002710	nucleotide binding site [chemical binding]; other site
693979002711	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
693979002712	KMSK motif region; other site
693979002713	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
693979002714	tRNA binding surface [nucleotide binding]; other site
693979002715	anticodon binding site; other site
693979002716	DNA topoisomerase I; Provisional; Region: PRK08780
693979002717	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
693979002718	active site
693979002719	interdomain interaction site; other site
693979002720	putative metal-binding site [ion binding]; other site
693979002721	nucleotide binding site [chemical binding]; other site
693979002722	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
693979002723	domain I; other site
693979002724	DNA binding groove [nucleotide binding]
693979002725	phosphate binding site [ion binding]; other site
693979002726	domain II; other site
693979002727	domain III; other site
693979002728	nucleotide binding site [chemical binding]; other site
693979002729	catalytic site [active]
693979002730	domain IV; other site
693979002731	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
693979002732	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
693979002733	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
693979002734	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979002735	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
693979002736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979002737	binding surface
693979002738	TPR motif; other site
693979002739	TPR repeat; Region: TPR_11; pfam13414
693979002740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979002741	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
693979002742	binding surface
693979002743	TPR motif; other site
693979002744	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
693979002745	nudix motif; other site
693979002746	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
693979002747	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
693979002748	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
693979002749	LPP20 lipoprotein; Region: LPP20; pfam02169
693979002750	PEGA domain; Region: PEGA; pfam08308
693979002751	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
693979002752	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
693979002753	active site
693979002754	catalytic site [active]
693979002755	substrate binding site [chemical binding]; other site
693979002756	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
693979002757	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
693979002758	active site
693979002759	dimerization interface [polypeptide binding]; other site
693979002760	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
693979002761	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979002762	active site
693979002763	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
693979002764	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693979002765	substrate binding site [chemical binding]; other site
693979002766	ATP binding site [chemical binding]; other site
693979002767	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693979002768	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979002769	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693979002770	protein binding site [polypeptide binding]; other site
693979002771	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
693979002772	Catalytic dyad [active]
693979002773	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
693979002774	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
693979002775	AIR carboxylase; Region: AIRC; pfam00731
693979002776	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
693979002777	lipoyl attachment site [posttranslational modification]; other site
693979002778	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
693979002779	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
693979002780	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
693979002781	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
693979002782	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
693979002783	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979002784	Sulfatase; Region: Sulfatase; pfam00884
693979002785	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
693979002786	proline aminopeptidase P II; Provisional; Region: PRK10879
693979002787	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
693979002788	active site
693979002789	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979002790	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979002791	catalytic residues [active]
693979002792	natural product precursor, GG-Bacteroidales family; Region: GG_sam_targ_CFB; TIGR04149
693979002793	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
693979002794	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
693979002795	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979002796	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979002797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979002798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002799	ATP binding site [chemical binding]; other site
693979002800	Mg2+ binding site [ion binding]; other site
693979002801	G-X-G motif; other site
693979002802	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
693979002803	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
693979002804	active site
693979002805	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
693979002806	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
693979002807	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
693979002808	PhoU domain; Region: PhoU; pfam01895
693979002809	Rubredoxin [Energy production and conversion]; Region: COG1773
693979002810	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
693979002811	iron binding site [ion binding]; other site
693979002812	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
693979002813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979002814	dimer interface [polypeptide binding]; other site
693979002815	phosphorylation site [posttranslational modification]
693979002816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002817	ATP binding site [chemical binding]; other site
693979002818	Mg2+ binding site [ion binding]; other site
693979002819	G-X-G motif; other site
693979002820	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
693979002821	Ligand binding site; other site
693979002822	Putative Catalytic site; other site
693979002823	DXD motif; other site
693979002824	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
693979002825	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578
693979002826	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
693979002827	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979002828	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
693979002829	putative NAD(P) binding site [chemical binding]; other site
693979002830	active site
693979002831	putative substrate binding site [chemical binding]; other site
693979002832	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
693979002833	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
693979002834	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
693979002835	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
693979002836	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
693979002837	motif II; other site
693979002838	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
693979002839	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
693979002840	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
693979002841	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
693979002842	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
693979002843	active site
693979002844	Riboflavin kinase; Region: Flavokinase; pfam01687
693979002845	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
693979002846	CAAX protease self-immunity; Region: Abi; pfam02517
693979002847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979002848	non-specific DNA binding site [nucleotide binding]; other site
693979002849	salt bridge; other site
693979002850	sequence-specific DNA binding site [nucleotide binding]; other site
693979002851	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
693979002852	M28 Zn-Peptidases; Region: M28_like_6; cd08656
693979002853	Peptidase family M28; Region: Peptidase_M28; pfam04389
693979002854	metal binding site [ion binding]; metal-binding site
693979002855	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
693979002856	dimer interface [polypeptide binding]; other site
693979002857	catalytic triad [active]
693979002858	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
693979002859	butyrate kinase; Provisional; Region: PRK03011
693979002860	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
693979002861	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
693979002862	RNase E interface [polypeptide binding]; other site
693979002863	trimer interface [polypeptide binding]; other site
693979002864	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
693979002865	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
693979002866	RNase E interface [polypeptide binding]; other site
693979002867	trimer interface [polypeptide binding]; other site
693979002868	active site
693979002869	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
693979002870	RNA binding site [nucleotide binding]; other site
693979002871	domain interface; other site
693979002872	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979002873	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
693979002874	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979002875	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
693979002876	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
693979002877	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
693979002878	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
693979002879	nucleotide binding site/active site [active]
693979002880	HIT family signature motif; other site
693979002881	catalytic residue [active]
693979002882	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
693979002883	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
693979002884	Substrate binding site; other site
693979002885	Fic family protein [Function unknown]; Region: COG3177
693979002886	Fic/DOC family; Region: Fic; pfam02661
693979002887	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
693979002888	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
693979002889	active site
693979002890	FMN binding site [chemical binding]; other site
693979002891	substrate binding site [chemical binding]; other site
693979002892	putative catalytic residue [active]
693979002893	Predicted transcriptional regulators [Transcription]; Region: COG1733
693979002894	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
693979002895	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979002896	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
693979002897	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979002898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002899	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
693979002900	putative FMN binding site [chemical binding]; other site
693979002901	Predicted transcriptional regulators [Transcription]; Region: COG1733
693979002902	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
693979002903	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
693979002904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979002905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002906	ATP binding site [chemical binding]; other site
693979002907	Mg2+ binding site [ion binding]; other site
693979002908	G-X-G motif; other site
693979002909	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
693979002910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979002911	active site
693979002912	phosphorylation site [posttranslational modification]
693979002913	intermolecular recognition site; other site
693979002914	dimerization interface [polypeptide binding]; other site
693979002915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979002916	Walker A motif; other site
693979002917	ATP binding site [chemical binding]; other site
693979002918	Walker B motif; other site
693979002919	arginine finger; other site
693979002920	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979002921	Outer membrane efflux protein; Region: OEP; pfam02321
693979002922	Outer membrane efflux protein; Region: OEP; pfam02321
693979002923	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979002924	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979002925	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979002926	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979002927	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979002928	Walker A/P-loop; other site
693979002929	ATP binding site [chemical binding]; other site
693979002930	Q-loop/lid; other site
693979002931	ABC transporter signature motif; other site
693979002932	Walker B; other site
693979002933	D-loop; other site
693979002934	H-loop/switch region; other site
693979002935	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979002936	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979002937	FtsX-like permease family; Region: FtsX; pfam02687
693979002938	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979002939	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979002940	FtsX-like permease family; Region: FtsX; pfam02687
693979002941	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
693979002942	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
693979002943	inhibitor binding site; inhibition site
693979002944	active site
693979002945	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
693979002946	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
693979002947	ligand binding site [chemical binding]; other site
693979002948	Peptidase C13 family; Region: Peptidase_C13; pfam01650
693979002949	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
693979002950	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979002951	MAC/Perforin domain; Region: MACPF; cl02616
693979002952	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979002953	MAC/Perforin domain; Region: MACPF; cl02616
693979002954	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979002955	MAC/Perforin domain; Region: MACPF; cl02616
693979002956	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979002957	Two component regulator propeller; Region: Reg_prop; pfam07494
693979002958	Two component regulator propeller; Region: Reg_prop; pfam07494
693979002959	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979002960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979002961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979002962	dimer interface [polypeptide binding]; other site
693979002963	phosphorylation site [posttranslational modification]
693979002964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979002965	ATP binding site [chemical binding]; other site
693979002966	Mg2+ binding site [ion binding]; other site
693979002967	G-X-G motif; other site
693979002968	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
693979002969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979002970	active site
693979002971	phosphorylation site [posttranslational modification]
693979002972	intermolecular recognition site; other site
693979002973	dimerization interface [polypeptide binding]; other site
693979002974	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
693979002975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979002977	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
693979002978	PA14 domain; Region: PA14; cl08459
693979002979	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
693979002980	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
693979002981	putative active site [active]
693979002982	putative catalytic site [active]
693979002983	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
693979002984	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
693979002985	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
693979002986	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979002987	ATP binding site [chemical binding]; other site
693979002988	putative Mg++ binding site [ion binding]; other site
693979002989	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979002990	nucleotide binding region [chemical binding]; other site
693979002991	ATP-binding site [chemical binding]; other site
693979002992	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
693979002993	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
693979002994	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
693979002995	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
693979002996	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
693979002997	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
693979002998	dimer interface [polypeptide binding]; other site
693979002999	active site
693979003000	metal binding site [ion binding]; metal-binding site
693979003001	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003002	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979003003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003004	RteC protein; Region: RteC; pfam09357
693979003005	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979003006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979003007	primosomal protein N' Region: priA; TIGR00595
693979003008	ATP binding site [chemical binding]; other site
693979003009	putative Mg++ binding site [ion binding]; other site
693979003010	helicase superfamily c-terminal domain; Region: HELICc; smart00490
693979003011	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
693979003012	Low molecular weight phosphatase family; Region: LMWPc; cd00115
693979003013	active site
693979003014	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
693979003015	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
693979003016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693979003017	Zn2+ binding site [ion binding]; other site
693979003018	Mg2+ binding site [ion binding]; other site
693979003019	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
693979003020	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
693979003021	HIGH motif; other site
693979003022	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
693979003023	active site
693979003024	KMSKS motif; other site
693979003025	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
693979003026	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
693979003027	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
693979003028	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
693979003029	trimer interface [polypeptide binding]; other site
693979003030	putative metal binding site [ion binding]; other site
693979003031	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
693979003032	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
693979003033	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
693979003034	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
693979003035	active site
693979003036	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
693979003037	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
693979003038	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
693979003039	active site
693979003040	Int/Topo IB signature motif; other site
693979003041	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
693979003042	30S subunit binding site; other site
693979003043	elongation factor Tu; Reviewed; Region: PRK12735
693979003044	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
693979003045	G1 box; other site
693979003046	GEF interaction site [polypeptide binding]; other site
693979003047	GTP/Mg2+ binding site [chemical binding]; other site
693979003048	Switch I region; other site
693979003049	G2 box; other site
693979003050	G3 box; other site
693979003051	Switch II region; other site
693979003052	G4 box; other site
693979003053	G5 box; other site
693979003054	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
693979003055	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
693979003056	Antibiotic Binding Site [chemical binding]; other site
693979003057	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
693979003058	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
693979003059	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
693979003060	putative homodimer interface [polypeptide binding]; other site
693979003061	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
693979003062	heterodimer interface [polypeptide binding]; other site
693979003063	homodimer interface [polypeptide binding]; other site
693979003064	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
693979003065	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
693979003066	23S rRNA interface [nucleotide binding]; other site
693979003067	L7/L12 interface [polypeptide binding]; other site
693979003068	putative thiostrepton binding site; other site
693979003069	L25 interface [polypeptide binding]; other site
693979003070	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
693979003071	mRNA/rRNA interface [nucleotide binding]; other site
693979003072	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
693979003073	23S rRNA interface [nucleotide binding]; other site
693979003074	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
693979003075	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
693979003076	core dimer interface [polypeptide binding]; other site
693979003077	peripheral dimer interface [polypeptide binding]; other site
693979003078	L10 interface [polypeptide binding]; other site
693979003079	L11 interface [polypeptide binding]; other site
693979003080	putative EF-Tu interaction site [polypeptide binding]; other site
693979003081	putative EF-G interaction site [polypeptide binding]; other site
693979003082	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
693979003083	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
693979003084	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
693979003085	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
693979003086	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
693979003087	RPB12 interaction site [polypeptide binding]; other site
693979003088	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
693979003089	RPB3 interaction site [polypeptide binding]; other site
693979003090	RPB1 interaction site [polypeptide binding]; other site
693979003091	RPB11 interaction site [polypeptide binding]; other site
693979003092	RPB10 interaction site [polypeptide binding]; other site
693979003093	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
693979003094	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
693979003095	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
693979003096	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
693979003097	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
693979003098	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
693979003099	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
693979003100	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
693979003101	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
693979003102	DNA binding site [nucleotide binding]
693979003103	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
693979003104	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
693979003105	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
693979003106	S17 interaction site [polypeptide binding]; other site
693979003107	S8 interaction site; other site
693979003108	16S rRNA interaction site [nucleotide binding]; other site
693979003109	streptomycin interaction site [chemical binding]; other site
693979003110	23S rRNA interaction site [nucleotide binding]; other site
693979003111	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
693979003112	30S ribosomal protein S7; Validated; Region: PRK05302
693979003113	elongation factor G; Reviewed; Region: PRK12739
693979003114	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
693979003115	G1 box; other site
693979003116	putative GEF interaction site [polypeptide binding]; other site
693979003117	GTP/Mg2+ binding site [chemical binding]; other site
693979003118	Switch I region; other site
693979003119	G2 box; other site
693979003120	G3 box; other site
693979003121	Switch II region; other site
693979003122	G4 box; other site
693979003123	G5 box; other site
693979003124	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
693979003125	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
693979003126	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
693979003127	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
693979003128	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
693979003129	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
693979003130	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
693979003131	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
693979003132	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
693979003133	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
693979003134	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
693979003135	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
693979003136	putative translocon binding site; other site
693979003137	protein-rRNA interface [nucleotide binding]; other site
693979003138	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
693979003139	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
693979003140	G-X-X-G motif; other site
693979003141	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
693979003142	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
693979003143	23S rRNA interface [nucleotide binding]; other site
693979003144	5S rRNA interface [nucleotide binding]; other site
693979003145	putative antibiotic binding site [chemical binding]; other site
693979003146	L25 interface [polypeptide binding]; other site
693979003147	L27 interface [polypeptide binding]; other site
693979003148	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
693979003149	23S rRNA interface [nucleotide binding]; other site
693979003150	putative translocon interaction site; other site
693979003151	signal recognition particle (SRP54) interaction site; other site
693979003152	L23 interface [polypeptide binding]; other site
693979003153	trigger factor interaction site; other site
693979003154	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
693979003155	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
693979003156	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
693979003157	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
693979003158	RNA binding site [nucleotide binding]; other site
693979003159	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
693979003160	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
693979003161	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
693979003162	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
693979003163	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
693979003164	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
693979003165	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
693979003166	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
693979003167	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
693979003168	5S rRNA interface [nucleotide binding]; other site
693979003169	L27 interface [polypeptide binding]; other site
693979003170	23S rRNA interface [nucleotide binding]; other site
693979003171	L5 interface [polypeptide binding]; other site
693979003172	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
693979003173	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
693979003174	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
693979003175	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
693979003176	23S rRNA binding site [nucleotide binding]; other site
693979003177	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
693979003178	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
693979003179	SecY translocase; Region: SecY; pfam00344
693979003180	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
693979003181	active site
693979003182	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
693979003183	rRNA binding site [nucleotide binding]; other site
693979003184	predicted 30S ribosome binding site; other site
693979003185	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
693979003186	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
693979003187	30S ribosomal protein S13; Region: bact_S13; TIGR03631
693979003188	30S ribosomal protein S11; Validated; Region: PRK05309
693979003189	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
693979003190	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
693979003191	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693979003192	RNA binding surface [nucleotide binding]; other site
693979003193	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
693979003194	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
693979003195	alphaNTD - beta interaction site [polypeptide binding]; other site
693979003196	alphaNTD homodimer interface [polypeptide binding]; other site
693979003197	alphaNTD - beta' interaction site [polypeptide binding]; other site
693979003198	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
693979003199	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
693979003200	MutS domain III; Region: MutS_III; pfam05192
693979003201	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
693979003202	Walker A/P-loop; other site
693979003203	ATP binding site [chemical binding]; other site
693979003204	Q-loop/lid; other site
693979003205	ABC transporter signature motif; other site
693979003206	Walker B; other site
693979003207	D-loop; other site
693979003208	H-loop/switch region; other site
693979003209	urocanate hydratase; Provisional; Region: PRK05414
693979003210	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
693979003211	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
693979003212	Formiminotransferase domain; Region: FTCD; pfam02971
693979003213	imidazolonepropionase; Validated; Region: PRK09356
693979003214	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
693979003215	active site
693979003216	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
693979003217	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
693979003218	active sites [active]
693979003219	tetramer interface [polypeptide binding]; other site
693979003220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693979003221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
693979003222	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
693979003223	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979003224	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979003225	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979003226	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979003227	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
693979003228	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
693979003229	active site
693979003230	oxyanion hole [active]
693979003231	catalytic triad [active]
693979003232	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
693979003233	active site
693979003234	catalytic triad [active]
693979003235	oxyanion hole [active]
693979003236	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
693979003237	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
693979003238	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
693979003239	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
693979003240	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979003241	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979003242	PBP superfamily domain; Region: PBP_like_2; pfam12849
693979003243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
693979003244	binding surface
693979003245	TPR motif; other site
693979003246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979003247	binding surface
693979003248	TPR motif; other site
693979003249	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
693979003250	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
693979003251	Walker A/P-loop; other site
693979003252	ATP binding site [chemical binding]; other site
693979003253	Q-loop/lid; other site
693979003254	ABC transporter signature motif; other site
693979003255	Walker B; other site
693979003256	D-loop; other site
693979003257	H-loop/switch region; other site
693979003258	Predicted transcriptional regulators [Transcription]; Region: COG1725
693979003259	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
693979003260	DNA-binding site [nucleotide binding]; DNA binding site
693979003261	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979003262	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979003263	catalytic residues [active]
693979003264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693979003265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
693979003266	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
693979003267	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
693979003268	NAD(P) binding site [chemical binding]; other site
693979003269	homotetramer interface [polypeptide binding]; other site
693979003270	homodimer interface [polypeptide binding]; other site
693979003271	active site
693979003272	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
693979003273	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693979003274	active site
693979003275	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
693979003276	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
693979003277	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
693979003278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979003279	Walker A/P-loop; other site
693979003280	ATP binding site [chemical binding]; other site
693979003281	Q-loop/lid; other site
693979003282	ABC transporter signature motif; other site
693979003283	Walker B; other site
693979003284	D-loop; other site
693979003285	H-loop/switch region; other site
693979003286	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
693979003287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
693979003288	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003289	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979003290	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003291	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979003292	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
693979003293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979003294	active site
693979003295	phosphorylation site [posttranslational modification]
693979003296	intermolecular recognition site; other site
693979003297	dimerization interface [polypeptide binding]; other site
693979003298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979003299	Walker A motif; other site
693979003300	ATP binding site [chemical binding]; other site
693979003301	Walker B motif; other site
693979003302	arginine finger; other site
693979003303	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979003304	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
693979003305	active site
693979003306	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
693979003307	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979003308	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979003309	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979003310	multidrug efflux protein; Reviewed; Region: PRK01766
693979003311	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
693979003312	cation binding site [ion binding]; other site
693979003313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979003314	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979003315	dimer interface [polypeptide binding]; other site
693979003316	phosphorylation site [posttranslational modification]
693979003317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979003318	ATP binding site [chemical binding]; other site
693979003319	Mg2+ binding site [ion binding]; other site
693979003320	G-X-G motif; other site
693979003321	Response regulator receiver domain; Region: Response_reg; pfam00072
693979003322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979003323	active site
693979003324	phosphorylation site [posttranslational modification]
693979003325	intermolecular recognition site; other site
693979003326	dimerization interface [polypeptide binding]; other site
693979003327	Family of unknown function (DUF490); Region: DUF490; pfam04357
693979003328	Surface antigen; Region: Bac_surface_Ag; pfam01103
693979003329	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979003330	active site
693979003331	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
693979003332	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
693979003333	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979003334	Walker A/P-loop; other site
693979003335	ATP binding site [chemical binding]; other site
693979003336	Q-loop/lid; other site
693979003337	ABC transporter signature motif; other site
693979003338	Walker B; other site
693979003339	D-loop; other site
693979003340	H-loop/switch region; other site
693979003341	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
693979003342	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
693979003343	AAA domain; Region: AAA_14; pfam13173
693979003344	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
693979003345	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979003346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979003347	Walker A/P-loop; other site
693979003348	ATP binding site [chemical binding]; other site
693979003349	Q-loop/lid; other site
693979003350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979003351	ABC transporter signature motif; other site
693979003352	Walker B; other site
693979003353	D-loop; other site
693979003354	ABC transporter; Region: ABC_tran_2; pfam12848
693979003355	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979003356	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
693979003357	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
693979003358	active site
693979003359	Zn binding site [ion binding]; other site
693979003360	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
693979003361	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
693979003362	purine monophosphate binding site [chemical binding]; other site
693979003363	dimer interface [polypeptide binding]; other site
693979003364	putative catalytic residues [active]
693979003365	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
693979003366	rod shape-determining protein MreB; Provisional; Region: PRK13927
693979003367	MreB and similar proteins; Region: MreB_like; cd10225
693979003368	nucleotide binding site [chemical binding]; other site
693979003369	Mg binding site [ion binding]; other site
693979003370	putative protofilament interaction site [polypeptide binding]; other site
693979003371	RodZ interaction site [polypeptide binding]; other site
693979003372	rod shape-determining protein MreC; Provisional; Region: PRK13922
693979003373	rod shape-determining protein MreC; Region: MreC; pfam04085
693979003374	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
693979003375	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
693979003376	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
693979003377	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
693979003378	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
693979003379	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
693979003380	GldH lipoprotein; Region: GldH_lipo; pfam14109
693979003381	PSP1 C-terminal conserved region; Region: PSP1; cl00770
693979003382	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
693979003383	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
693979003384	FAD binding site [chemical binding]; other site
693979003385	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979003386	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979003387	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
693979003388	homoserine O-succinyltransferase; Provisional; Region: PRK05368
693979003389	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
693979003390	proposed active site lysine [active]
693979003391	conserved cys residue [active]
693979003392	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
693979003393	Peptidase family U32; Region: Peptidase_U32; pfam01136
693979003394	Collagenase; Region: DUF3656; pfam12392
693979003395	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693979003396	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003397	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003398	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979003399	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979003400	DNA binding residues [nucleotide binding]
693979003401	dimerization interface [polypeptide binding]; other site
693979003402	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
693979003403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
693979003404	DNA repair protein RadA; Provisional; Region: PRK11823
693979003405	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
693979003406	Walker A motif/ATP binding site; other site
693979003407	ATP binding site [chemical binding]; other site
693979003408	Walker B motif; other site
693979003409	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
693979003410	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
693979003411	active site
693979003412	homodimer interface [polypeptide binding]; other site
693979003413	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
693979003414	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
693979003415	nucleotide binding site [chemical binding]; other site
693979003416	substrate binding site [chemical binding]; other site
693979003417	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
693979003418	dimer interface [polypeptide binding]; other site
693979003419	putative threonine allosteric regulatory site; other site
693979003420	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
693979003421	putative threonine allosteric regulatory site; other site
693979003422	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
693979003423	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
693979003424	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
693979003425	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
693979003426	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
693979003427	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
693979003428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979003429	catalytic residue [active]
693979003430	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
693979003431	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
693979003432	active site
693979003433	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979003434	Thiamine pyrophosphokinase; Region: TPK; cd07995
693979003435	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
693979003436	active site
693979003437	dimerization interface [polypeptide binding]; other site
693979003438	thiamine binding site [chemical binding]; other site
693979003439	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
693979003440	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979003441	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003442	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693979003443	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
693979003444	EamA-like transporter family; Region: EamA; pfam00892
693979003445	EamA-like transporter family; Region: EamA; pfam00892
693979003446	Domain of unknown function DUF20; Region: UPF0118; pfam01594
693979003447	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
693979003448	thymidine kinase; Provisional; Region: PRK04296
693979003449	Predicted methyltransferases [General function prediction only]; Region: COG0313
693979003450	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
693979003451	putative SAM binding site [chemical binding]; other site
693979003452	putative homodimer interface [polypeptide binding]; other site
693979003453	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
693979003454	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
693979003455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979003456	motif II; other site
693979003457	MarC family integral membrane protein; Region: MarC; pfam01914
693979003458	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979003459	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979003460	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003461	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979003462	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003463	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979003464	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979003465	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979003466	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979003467	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
693979003468	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979003469	active site
693979003470	DNA binding site [nucleotide binding]
693979003471	Int/Topo IB signature motif; other site
693979003472	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979003473	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003474	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979003475	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003476	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979003477	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979003478	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
693979003479	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
693979003480	HflX GTPase family; Region: HflX; cd01878
693979003481	G1 box; other site
693979003482	GTP/Mg2+ binding site [chemical binding]; other site
693979003483	Switch I region; other site
693979003484	G2 box; other site
693979003485	G3 box; other site
693979003486	Switch II region; other site
693979003487	G4 box; other site
693979003488	G5 box; other site
693979003489	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
693979003490	putative trimer interface [polypeptide binding]; other site
693979003491	putative CoA binding site [chemical binding]; other site
693979003492	fumarate hydratase; Provisional; Region: PRK15389
693979003493	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
693979003494	Fumarase C-terminus; Region: Fumerase_C; pfam05683
693979003495	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
693979003496	Acyltransferase family; Region: Acyl_transf_3; pfam01757
693979003497	GTPase RsgA; Reviewed; Region: PRK00098
693979003498	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
693979003499	RNA binding site [nucleotide binding]; other site
693979003500	homodimer interface [polypeptide binding]; other site
693979003501	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
693979003502	GTPase/Zn-binding domain interface [polypeptide binding]; other site
693979003503	GTP/Mg2+ binding site [chemical binding]; other site
693979003504	G4 box; other site
693979003505	G5 box; other site
693979003506	G1 box; other site
693979003507	Switch I region; other site
693979003508	G2 box; other site
693979003509	G3 box; other site
693979003510	Switch II region; other site
693979003511	ribosome recycling factor; Reviewed; Region: frr; PRK00083
693979003512	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
693979003513	hinge region; other site
693979003514	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
693979003515	putative nucleotide binding site [chemical binding]; other site
693979003516	uridine monophosphate binding site [chemical binding]; other site
693979003517	homohexameric interface [polypeptide binding]; other site
693979003518	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
693979003519	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
693979003520	metal-binding site [ion binding]
693979003521	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
693979003522	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
693979003523	Soluble P-type ATPase [General function prediction only]; Region: COG4087
693979003524	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979003525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003526	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693979003527	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
693979003528	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
693979003529	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
693979003530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979003531	binding surface
693979003532	TPR motif; other site
693979003533	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003534	GLPGLI family protein; Region: GLPGLI; TIGR01200
693979003535	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
693979003536	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979003537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979003538	binding surface
693979003539	TPR motif; other site
693979003540	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
693979003541	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
693979003542	Protein of unknown function (DUF419); Region: DUF419; pfam04237
693979003543	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
693979003544	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693979003545	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
693979003546	protein binding site [polypeptide binding]; other site
693979003547	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
693979003548	Catalytic dyad [active]
693979003549	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
693979003550	nucleoside/Zn binding site; other site
693979003551	dimer interface [polypeptide binding]; other site
693979003552	catalytic motif [active]
693979003553	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
693979003554	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
693979003555	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
693979003556	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
693979003557	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
693979003558	active site
693979003559	PHP Thumb interface [polypeptide binding]; other site
693979003560	metal binding site [ion binding]; metal-binding site
693979003561	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
693979003562	generic binding surface II; other site
693979003563	generic binding surface I; other site
693979003564	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693979003565	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979003566	catalytic residues [active]
693979003567	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
693979003568	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
693979003569	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
693979003570	ABC-ATPase subunit  interface; other site
693979003571	dimer interface [polypeptide binding]; other site
693979003572	putative PBP binding regions; other site
693979003573	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
693979003574	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
693979003575	hinge; other site
693979003576	active site
693979003577	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
693979003578	hypothetical protein; Provisional; Region: PRK07101
693979003579	para-aminobenzoate synthase component I; Validated; Region: PRK07093
693979003580	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979003581	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979003582	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979003583	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979003584	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
693979003585	protein binding site [polypeptide binding]; other site
693979003586	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
693979003587	Domain interface; other site
693979003588	Active site tetrad [active]
693979003589	Peptide binding site; other site
693979003590	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
693979003591	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
693979003592	putative metal binding site [ion binding]; other site
693979003593	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
693979003594	HSP70 interaction site [polypeptide binding]; other site
693979003595	NigD-like protein; Region: NigD; pfam12667
693979003596	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979003597	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
693979003598	active site
693979003599	dimer interface [polypeptide binding]; other site
693979003600	metal binding site [ion binding]; metal-binding site
693979003601	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
693979003602	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
693979003603	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
693979003604	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
693979003605	putative active site [active]
693979003606	catalytic site [active]
693979003607	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
693979003608	putative active site [active]
693979003609	catalytic site [active]
693979003610	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
693979003611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979003612	S-adenosylmethionine binding site [chemical binding]; other site
693979003613	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
693979003614	AAA domain; Region: AAA_30; pfam13604
693979003615	Family description; Region: UvrD_C_2; pfam13538
693979003616	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
693979003617	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
693979003618	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
693979003619	motif 1; other site
693979003620	active site
693979003621	motif 2; other site
693979003622	motif 3; other site
693979003623	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
693979003624	DHHA1 domain; Region: DHHA1; pfam02272
693979003625	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
693979003626	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979003627	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
693979003628	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
693979003629	DNA binding residues [nucleotide binding]
693979003630	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
693979003631	HD domain; Region: HD_4; pfam13328
693979003632	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
693979003633	synthetase active site [active]
693979003634	NTP binding site [chemical binding]; other site
693979003635	metal binding site [ion binding]; metal-binding site
693979003636	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
693979003637	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
693979003638	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
693979003639	N-acetyl-D-glucosamine binding site [chemical binding]; other site
693979003640	catalytic residue [active]
693979003641	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979003642	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
693979003643	ParB-like nuclease domain; Region: ParB; smart00470
693979003644	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
693979003645	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
693979003646	P-loop; other site
693979003647	Magnesium ion binding site [ion binding]; other site
693979003648	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
693979003649	Magnesium ion binding site [ion binding]; other site
693979003650	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
693979003651	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
693979003652	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
693979003653	NigD-like protein; Region: NigD; pfam12667
693979003654	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
693979003655	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
693979003656	FtsH Extracellular; Region: FtsH_ext; pfam06480
693979003657	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
693979003658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979003659	Walker A motif; other site
693979003660	ATP binding site [chemical binding]; other site
693979003661	Walker B motif; other site
693979003662	arginine finger; other site
693979003663	Peptidase family M41; Region: Peptidase_M41; pfam01434
693979003664	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
693979003665	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693979003666	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693979003667	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693979003668	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693979003669	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
693979003670	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
693979003671	MgtE intracellular N domain; Region: MgtE_N; smart00924
693979003672	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
693979003673	Divalent cation transporter; Region: MgtE; pfam01769
693979003674	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
693979003675	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
693979003676	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
693979003677	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
693979003678	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
693979003679	metal binding site [ion binding]; metal-binding site
693979003680	dimer interface [polypeptide binding]; other site
693979003681	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
693979003682	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979003683	MG2 domain; Region: A2M_N; pfam01835
693979003684	Alpha-2-macroglobulin family; Region: A2M; pfam00207
693979003685	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
693979003686	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
693979003687	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
693979003688	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
693979003689	membrane ATPase/protein kinase; Provisional; Region: PRK09435
693979003690	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
693979003691	Walker A; other site
693979003692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979003693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979003694	dimer interface [polypeptide binding]; other site
693979003695	phosphorylation site [posttranslational modification]
693979003696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979003697	ATP binding site [chemical binding]; other site
693979003698	Mg2+ binding site [ion binding]; other site
693979003699	G-X-G motif; other site
693979003700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979003701	AAA domain; Region: AAA_21; pfam13304
693979003702	Walker A/P-loop; other site
693979003703	ATP binding site [chemical binding]; other site
693979003704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979003705	ABC transporter signature motif; other site
693979003706	Walker B; other site
693979003707	D-loop; other site
693979003708	H-loop/switch region; other site
693979003709	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
693979003710	Mechanosensitive ion channel; Region: MS_channel; pfam00924
693979003711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979003712	HAMP domain; Region: HAMP; pfam00672
693979003713	dimerization interface [polypeptide binding]; other site
693979003714	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979003715	dimer interface [polypeptide binding]; other site
693979003716	phosphorylation site [posttranslational modification]
693979003717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979003718	ATP binding site [chemical binding]; other site
693979003719	Mg2+ binding site [ion binding]; other site
693979003720	G-X-G motif; other site
693979003721	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693979003722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979003723	active site
693979003724	phosphorylation site [posttranslational modification]
693979003725	intermolecular recognition site; other site
693979003726	dimerization interface [polypeptide binding]; other site
693979003727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693979003728	DNA binding site [nucleotide binding]
693979003729	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979003730	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003731	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979003732	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003733	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979003734	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979003735	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979003736	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979003737	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
693979003738	Protein export membrane protein; Region: SecD_SecF; cl14618
693979003739	Outer membrane efflux protein; Region: OEP; pfam02321
693979003740	Outer membrane efflux protein; Region: OEP; pfam02321
693979003741	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979003742	Histidine kinase; Region: HisKA_3; pfam07730
693979003743	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
693979003744	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003745	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
693979003746	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003747	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
693979003748	GAF domain; Region: GAF; pfam01590
693979003749	PAS fold; Region: PAS_4; pfam08448
693979003750	PAS fold; Region: PAS_3; pfam08447
693979003751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979003752	dimer interface [polypeptide binding]; other site
693979003753	phosphorylation site [posttranslational modification]
693979003754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979003755	ATP binding site [chemical binding]; other site
693979003756	Mg2+ binding site [ion binding]; other site
693979003757	G-X-G motif; other site
693979003758	Erythromycin esterase; Region: Erythro_esteras; cl17110
693979003759	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
693979003760	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
693979003761	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
693979003762	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
693979003763	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
693979003764	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
693979003765	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
693979003766	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
693979003767	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
693979003768	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
693979003769	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
693979003770	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979003771	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
693979003772	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
693979003773	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
693979003774	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
693979003775	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
693979003776	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
693979003777	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
693979003778	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
693979003779	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
693979003780	TrkA-N domain; Region: TrkA_N; pfam02254
693979003781	TrkA-C domain; Region: TrkA_C; pfam02080
693979003782	TrkA-N domain; Region: TrkA_N; pfam02254
693979003783	TrkA-C domain; Region: TrkA_C; pfam02080
693979003784	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
693979003785	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
693979003786	TPP-binding site; other site
693979003787	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
693979003788	PYR/PP interface [polypeptide binding]; other site
693979003789	dimer interface [polypeptide binding]; other site
693979003790	TPP binding site [chemical binding]; other site
693979003791	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693979003792	Flavin Reductases; Region: FlaRed; cl00801
693979003793	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003794	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979003795	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003796	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
693979003797	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
693979003798	dimer interface [polypeptide binding]; other site
693979003799	active site
693979003800	metal binding site [ion binding]; metal-binding site
693979003801	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
693979003802	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
693979003803	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
693979003804	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979003805	putative active site [active]
693979003806	putative metal binding site [ion binding]; other site
693979003807	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
693979003808	Protein of unknown function (DUF2390); Region: DUF2390; cl02376
693979003809	Fic/DOC family; Region: Fic; pfam02661
693979003810	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979003811	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
693979003812	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979003813	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
693979003814	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693979003815	catalytic site [active]
693979003816	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979003817	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
693979003818	active site
693979003819	catalytic tetrad [active]
693979003820	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979003821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003822	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979003823	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003824	GSCFA family; Region: GSCFA; pfam08885
693979003825	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
693979003826	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
693979003827	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979003828	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
693979003829	active site
693979003830	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693979003831	dimer interface [polypeptide binding]; other site
693979003832	substrate binding site [chemical binding]; other site
693979003833	catalytic residues [active]
693979003834	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
693979003835	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
693979003836	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
693979003837	AAA domain; Region: AAA_11; pfam13086
693979003838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979003839	ATP binding site [chemical binding]; other site
693979003840	putative Mg++ binding site [ion binding]; other site
693979003841	AAA domain; Region: AAA_12; pfam13087
693979003842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979003843	putative substrate translocation pore; other site
693979003844	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
693979003845	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
693979003846	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
693979003847	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
693979003848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979003849	motif II; other site
693979003850	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
693979003851	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
693979003852	NAD binding site [chemical binding]; other site
693979003853	homotetramer interface [polypeptide binding]; other site
693979003854	homodimer interface [polypeptide binding]; other site
693979003855	substrate binding site [chemical binding]; other site
693979003856	active site
693979003857	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
693979003858	putative SAM binding site [chemical binding]; other site
693979003859	homodimer interface [polypeptide binding]; other site
693979003860	lipoyl synthase; Provisional; Region: PRK05481
693979003861	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979003862	FeS/SAM binding site; other site
693979003863	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
693979003864	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
693979003865	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
693979003866	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
693979003867	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
693979003868	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979003869	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
693979003870	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
693979003871	active site
693979003872	trimer interface [polypeptide binding]; other site
693979003873	allosteric site; other site
693979003874	active site lid [active]
693979003875	hexamer (dimer of trimers) interface [polypeptide binding]; other site
693979003876	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979003877	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979003878	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
693979003879	NVEALA protein; Region: NVEALA; pfam14055
693979003880	NVEALA protein; Region: NVEALA; pfam14055
693979003881	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
693979003882	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
693979003883	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693979003884	Catalytic site [active]
693979003885	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
693979003886	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
693979003887	O-Antigen ligase; Region: Wzy_C; pfam04932
693979003888	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979003889	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979003890	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979003891	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979003892	Protein export membrane protein; Region: SecD_SecF; cl14618
693979003893	Outer membrane efflux protein; Region: OEP; pfam02321
693979003894	Outer membrane efflux protein; Region: OEP; pfam02321
693979003895	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979003896	Protein export membrane protein; Region: SecD_SecF; cl14618
693979003897	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
693979003898	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979003899	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979003900	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
693979003901	putative active site [active]
693979003902	PIF1-like helicase; Region: PIF1; pfam05970
693979003903	AAA domain; Region: AAA_30; pfam13604
693979003904	Family description; Region: UvrD_C_2; pfam13538
693979003905	TPR repeat; Region: TPR_11; pfam13414
693979003906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979003907	binding surface
693979003908	TPR motif; other site
693979003909	TPR repeat; Region: TPR_11; pfam13414
693979003910	TPR repeat; Region: TPR_11; pfam13414
693979003911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979003912	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
693979003913	active site
693979003914	motif I; other site
693979003915	motif II; other site
693979003916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979003917	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
693979003918	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
693979003919	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
693979003920	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
693979003921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
693979003922	Imelysin; Region: Peptidase_M75; pfam09375
693979003923	Imelysin; Region: Peptidase_M75; pfam09375
693979003924	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
693979003925	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
693979003926	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
693979003927	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
693979003928	homotrimer interaction site [polypeptide binding]; other site
693979003929	putative active site [active]
693979003930	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
693979003931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979003932	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979003933	DNA binding residues [nucleotide binding]
693979003934	dimerization interface [polypeptide binding]; other site
693979003935	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
693979003936	Penicillinase repressor; Region: Pencillinase_R; pfam03965
693979003937	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979003938	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979003939	catalytic residues [active]
693979003940	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
693979003941	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979003942	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979003943	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979003944	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979003945	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979003946	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979003947	catalytic residues [active]
693979003948	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979003949	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979003950	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979003951	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979003952	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979003953	SusD family; Region: SusD; pfam07980
693979003954	Two component regulator propeller; Region: Reg_prop; pfam07494
693979003955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979003956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979003957	dimer interface [polypeptide binding]; other site
693979003958	phosphorylation site [posttranslational modification]
693979003959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979003960	ATP binding site [chemical binding]; other site
693979003961	Mg2+ binding site [ion binding]; other site
693979003962	G-X-G motif; other site
693979003963	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
693979003964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979003965	active site
693979003966	phosphorylation site [posttranslational modification]
693979003967	intermolecular recognition site; other site
693979003968	dimerization interface [polypeptide binding]; other site
693979003969	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979003970	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979003971	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
693979003972	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
693979003973	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
693979003974	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
693979003975	active site
693979003976	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
693979003977	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
693979003978	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
693979003979	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
693979003980	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
693979003981	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
693979003982	trimer interface [polypeptide binding]; other site
693979003983	active site
693979003984	UDP-GlcNAc binding site [chemical binding]; other site
693979003985	lipid binding site [chemical binding]; lipid-binding site
693979003986	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
693979003987	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693979003988	Zn2+ binding site [ion binding]; other site
693979003989	Mg2+ binding site [ion binding]; other site
693979003990	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
693979003991	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
693979003992	active site
693979003993	catalytic site [active]
693979003994	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979003995	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
693979003996	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979003997	sugar binding site [chemical binding]; other site
693979003998	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
693979003999	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979004000	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693979004001	ligand binding site [chemical binding]; other site
693979004002	flexible hinge region; other site
693979004003	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
693979004004	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979004005	active site
693979004006	catalytic tetrad [active]
693979004007	4Fe-4S binding domain; Region: Fer4_5; pfam12801
693979004008	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
693979004009	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
693979004010	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979004011	photosystem I iron-sulfur protein PsaC; Region: PS_I_psaC; TIGR03048
693979004012	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
693979004013	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979004014	active site
693979004015	catalytic tetrad [active]
693979004016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979004017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979004018	dimer interface [polypeptide binding]; other site
693979004019	phosphorylation site [posttranslational modification]
693979004020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979004021	ATP binding site [chemical binding]; other site
693979004022	Mg2+ binding site [ion binding]; other site
693979004023	G-X-G motif; other site
693979004024	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
693979004025	active site
693979004026	dimer interface [polypeptide binding]; other site
693979004027	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
693979004028	peptide chain release factor 1; Validated; Region: prfA; PRK00591
693979004029	This domain is found in peptide chain release factors; Region: PCRF; smart00937
693979004030	RF-1 domain; Region: RF-1; pfam00472
693979004031	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
693979004032	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
693979004033	dimerization interface [polypeptide binding]; other site
693979004034	ATP binding site [chemical binding]; other site
693979004035	Histidine kinase; Region: His_kinase; pfam06580
693979004036	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979004037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979004038	active site
693979004039	phosphorylation site [posttranslational modification]
693979004040	intermolecular recognition site; other site
693979004041	dimerization interface [polypeptide binding]; other site
693979004042	LytTr DNA-binding domain; Region: LytTR; smart00850
693979004043	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
693979004044	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
693979004045	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004046	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004047	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
693979004048	LemA family; Region: LemA; pfam04011
693979004049	Repair protein; Region: Repair_PSII; pfam04536
693979004050	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
693979004051	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
693979004052	Serine hydrolase (FSH1); Region: FSH1; pfam03959
693979004053	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
693979004054	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
693979004055	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
693979004056	shikimate binding site; other site
693979004057	NAD(P) binding site [chemical binding]; other site
693979004058	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
693979004059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979004060	S-adenosylmethionine binding site [chemical binding]; other site
693979004061	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
693979004062	ATP binding site [chemical binding]; other site
693979004063	active site
693979004064	substrate binding site [chemical binding]; other site
693979004065	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
693979004066	PhoH-like protein; Region: PhoH; pfam02562
693979004067	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
693979004068	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979004069	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
693979004070	B3/4 domain; Region: B3_4; pfam03483
693979004071	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
693979004072	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
693979004073	GTPase CgtA; Reviewed; Region: obgE; PRK12299
693979004074	GTP1/OBG; Region: GTP1_OBG; pfam01018
693979004075	Obg GTPase; Region: Obg; cd01898
693979004076	G1 box; other site
693979004077	GTP/Mg2+ binding site [chemical binding]; other site
693979004078	Switch I region; other site
693979004079	G2 box; other site
693979004080	G3 box; other site
693979004081	Switch II region; other site
693979004082	G4 box; other site
693979004083	G5 box; other site
693979004084	adenylate kinase; Reviewed; Region: adk; PRK00279
693979004085	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
693979004086	AMP-binding site [chemical binding]; other site
693979004087	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
693979004088	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979004089	active site
693979004090	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
693979004091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979004092	putative substrate translocation pore; other site
693979004093	POT family; Region: PTR2; cl17359
693979004094	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979004095	putative carbohydrate kinase; Provisional; Region: PRK10565
693979004096	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
693979004097	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
693979004098	putative substrate binding site [chemical binding]; other site
693979004099	putative ATP binding site [chemical binding]; other site
693979004100	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
693979004101	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
693979004102	dimerization interface 3.5A [polypeptide binding]; other site
693979004103	active site
693979004104	EamA-like transporter family; Region: EamA; cl17759
693979004105	EamA-like transporter family; Region: EamA; cl17759
693979004106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
693979004107	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
693979004108	GAF domain; Region: GAF_2; pfam13185
693979004109	Protein of unknown function (DUF3256); Region: DUF3256; pfam11644
693979004110	Uncharacterized conserved protein [Function unknown]; Region: COG1284
693979004111	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
693979004112	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
693979004113	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
693979004114	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
693979004115	homopentamer interface [polypeptide binding]; other site
693979004116	active site
693979004117	recombination protein F; Reviewed; Region: recF; PRK00064
693979004118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979004119	Walker A/P-loop; other site
693979004120	ATP binding site [chemical binding]; other site
693979004121	Q-loop/lid; other site
693979004122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979004123	ABC transporter signature motif; other site
693979004124	Walker B; other site
693979004125	D-loop; other site
693979004126	H-loop/switch region; other site
693979004127	Protein of unknown function (DUF721); Region: DUF721; pfam05258
693979004128	histidinol-phosphatase; Provisional; Region: PRK07328
693979004129	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
693979004130	active site
693979004131	dimer interface [polypeptide binding]; other site
693979004132	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
693979004133	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
693979004134	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
693979004135	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979004136	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
693979004137	protein binding site [polypeptide binding]; other site
693979004138	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
693979004139	Catalytic dyad [active]
693979004140	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
693979004141	catalytic motif [active]
693979004142	Zn binding site [ion binding]; other site
693979004143	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
693979004144	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
693979004145	active site
693979004146	Zn binding site [ion binding]; other site
693979004147	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
693979004148	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
693979004149	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
693979004150	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
693979004151	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
693979004152	GMP synthase; Reviewed; Region: guaA; PRK00074
693979004153	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
693979004154	AMP/PPi binding site [chemical binding]; other site
693979004155	candidate oxyanion hole; other site
693979004156	catalytic triad [active]
693979004157	potential glutamine specificity residues [chemical binding]; other site
693979004158	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
693979004159	ATP Binding subdomain [chemical binding]; other site
693979004160	Ligand Binding sites [chemical binding]; other site
693979004161	Dimerization subdomain; other site
693979004162	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979004163	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693979004164	ligand binding site [chemical binding]; other site
693979004165	flexible hinge region; other site
693979004166	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
693979004167	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
693979004168	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
693979004169	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
693979004170	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
693979004171	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
693979004172	N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795
693979004173	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
693979004174	putative active site [active]
693979004175	catalytic site [active]
693979004176	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
693979004177	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
693979004178	Pantoate-beta-alanine ligase; Region: PanC; cd00560
693979004179	pantoate--beta-alanine ligase; Region: panC; TIGR00018
693979004180	active site
693979004181	ATP-binding site [chemical binding]; other site
693979004182	pantoate-binding site; other site
693979004183	HXXH motif; other site
693979004184	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
693979004185	tetramerization interface [polypeptide binding]; other site
693979004186	active site
693979004187	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979004188	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
693979004189	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
693979004190	FAD binding pocket [chemical binding]; other site
693979004191	FAD binding motif [chemical binding]; other site
693979004192	phosphate binding motif [ion binding]; other site
693979004193	beta-alpha-beta structure motif; other site
693979004194	NAD binding pocket [chemical binding]; other site
693979004195	Iron coordination center [ion binding]; other site
693979004196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
693979004197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979004198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979004199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979004200	ATP binding site [chemical binding]; other site
693979004201	Mg2+ binding site [ion binding]; other site
693979004202	G-X-G motif; other site
693979004203	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979004204	seryl-tRNA synthetase; Provisional; Region: PRK05431
693979004205	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
693979004206	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
693979004207	dimer interface [polypeptide binding]; other site
693979004208	active site
693979004209	motif 1; other site
693979004210	motif 2; other site
693979004211	motif 3; other site
693979004212	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
693979004213	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
693979004214	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
693979004215	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
693979004216	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979004217	motif II; other site
693979004218	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
693979004219	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979004220	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979004221	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979004222	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979004223	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979004224	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979004225	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
693979004226	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
693979004227	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979004228	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979004229	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004230	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004231	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979004232	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004233	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004234	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004235	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979004236	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004237	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979004238	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
693979004239	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
693979004240	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979004241	Uncharacterized conserved protein [Function unknown]; Region: COG1262
693979004242	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
693979004243	BNR repeat-like domain; Region: BNR_2; pfam13088
693979004244	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
693979004245	Asp-box motif; other site
693979004246	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
693979004247	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979004248	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979004249	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979004250	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979004251	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979004252	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979004253	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
693979004254	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
693979004255	muropeptide transporter; Reviewed; Region: ampG; PRK11902
693979004256	muropeptide transporter; Validated; Region: ampG; cl17669
693979004257	Domain of unknown function (DUF377); Region: DUF377; pfam04041
693979004258	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
693979004259	active site
693979004260	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
693979004261	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
693979004262	TraB family; Region: TraB; pfam01963
693979004263	NlpC/P60 family; Region: NLPC_P60; pfam00877
693979004264	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
693979004265	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
693979004266	Walker A/P-loop; other site
693979004267	ATP binding site [chemical binding]; other site
693979004268	Q-loop/lid; other site
693979004269	ABC transporter signature motif; other site
693979004270	Walker B; other site
693979004271	D-loop; other site
693979004272	H-loop/switch region; other site
693979004273	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979004274	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979004275	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979004276	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979004277	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979004278	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
693979004279	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
693979004280	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
693979004281	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
693979004282	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
693979004283	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979004284	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004285	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979004286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004287	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
693979004288	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
693979004289	TrkA-C domain; Region: TrkA_C; pfam02080
693979004290	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
693979004291	TrkA-C domain; Region: TrkA_C; pfam02080
693979004292	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
693979004293	MutS domain III; Region: MutS_III; pfam05192
693979004294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979004295	Walker A/P-loop; other site
693979004296	ATP binding site [chemical binding]; other site
693979004297	Q-loop/lid; other site
693979004298	ABC transporter signature motif; other site
693979004299	Walker B; other site
693979004300	D-loop; other site
693979004301	H-loop/switch region; other site
693979004302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979004303	Walker A/P-loop; other site
693979004304	ATP binding site [chemical binding]; other site
693979004305	ABC transporter; Region: ABC_tran; pfam00005
693979004306	Q-loop/lid; other site
693979004307	ABC transporter signature motif; other site
693979004308	Walker B; other site
693979004309	D-loop; other site
693979004310	H-loop/switch region; other site
693979004311	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
693979004312	RNA methyltransferase, RsmE family; Region: TIGR00046
693979004313	Bifunctional nuclease; Region: DNase-RNase; pfam02577
693979004314	UvrB/uvrC motif; Region: UVR; pfam02151
693979004315	nucleoside transporter; Region: 2A0110; TIGR00889
693979004316	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
693979004317	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
693979004318	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
693979004319	putative RNA binding site [nucleotide binding]; other site
693979004320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979004321	S-adenosylmethionine binding site [chemical binding]; other site
693979004322	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
693979004323	catalytic site [active]
693979004324	putative active site [active]
693979004325	putative substrate binding site [chemical binding]; other site
693979004326	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
693979004327	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
693979004328	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
693979004329	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
693979004330	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
693979004331	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
693979004332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
693979004333	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979004334	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693979004335	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979004336	ligand binding site [chemical binding]; other site
693979004337	flexible hinge region; other site
693979004338	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
693979004339	putative switch regulator; other site
693979004340	non-specific DNA interactions [nucleotide binding]; other site
693979004341	DNA binding site [nucleotide binding]
693979004342	sequence specific DNA binding site [nucleotide binding]; other site
693979004343	putative cAMP binding site [chemical binding]; other site
693979004344	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
693979004345	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
693979004346	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
693979004347	pantothenate kinase; Provisional; Region: PRK13317
693979004348	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
693979004349	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
693979004350	RNA binding site [nucleotide binding]; other site
693979004351	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
693979004352	RNA binding site [nucleotide binding]; other site
693979004353	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
693979004354	RNA binding site [nucleotide binding]; other site
693979004355	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693979004356	RNA binding site [nucleotide binding]; other site
693979004357	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
693979004358	RNA binding site [nucleotide binding]; other site
693979004359	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
693979004360	RNA binding site [nucleotide binding]; other site
693979004361	ribonuclease Z; Region: RNase_Z; TIGR02651
693979004362	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979004363	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979004364	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979004365	DNA binding residues [nucleotide binding]
693979004366	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
693979004367	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
693979004368	homodimer interface [polypeptide binding]; other site
693979004369	metal binding site [ion binding]; metal-binding site
693979004370	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
693979004371	homodimer interface [polypeptide binding]; other site
693979004372	active site
693979004373	putative chemical substrate binding site [chemical binding]; other site
693979004374	metal binding site [ion binding]; metal-binding site
693979004375	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
693979004376	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
693979004377	conserved cys residue [active]
693979004378	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
693979004379	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
693979004380	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
693979004381	HIGH motif; other site
693979004382	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
693979004383	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
693979004384	active site
693979004385	KMSKS motif; other site
693979004386	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
693979004387	tRNA binding surface [nucleotide binding]; other site
693979004388	anticodon binding site; other site
693979004389	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
693979004390	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
693979004391	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
693979004392	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979004393	nucleotide binding region [chemical binding]; other site
693979004394	ATP-binding site [chemical binding]; other site
693979004395	SEC-C motif; Region: SEC-C; pfam02810
693979004396	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
693979004397	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
693979004398	pantothenate kinase; Reviewed; Region: PRK13320
693979004399	TPR repeat; Region: TPR_11; pfam13414
693979004400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979004401	TPR motif; other site
693979004402	binding surface
693979004403	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
693979004404	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
693979004405	Domain of unknown function DUF21; Region: DUF21; pfam01595
693979004406	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
693979004407	Transporter associated domain; Region: CorC_HlyC; smart01091
693979004408	SurA N-terminal domain; Region: SurA_N_2; pfam13623
693979004409	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
693979004410	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
693979004411	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466
693979004412	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
693979004413	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
693979004414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979004415	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
693979004416	Walker A motif; other site
693979004417	ATP binding site [chemical binding]; other site
693979004418	Walker B motif; other site
693979004419	arginine finger; other site
693979004420	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979004421	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
693979004422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979004423	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979004424	putative substrate translocation pore; other site
693979004425	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
693979004426	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
693979004427	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
693979004428	structural tetrad; other site
693979004429	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979004430	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979004431	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979004432	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
693979004433	metal binding site 2 [ion binding]; metal-binding site
693979004434	putative DNA binding helix; other site
693979004435	metal binding site 1 [ion binding]; metal-binding site
693979004436	dimer interface [polypeptide binding]; other site
693979004437	structural Zn2+ binding site [ion binding]; other site
693979004438	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
693979004439	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
693979004440	Soluble P-type ATPase [General function prediction only]; Region: COG4087
693979004441	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
693979004442	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
693979004443	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
693979004444	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979004445	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
693979004446	active site
693979004447	DNA polymerase IV; Validated; Region: PRK02406
693979004448	DNA binding site [nucleotide binding]
693979004449	hypothetical protein; Provisional; Region: PRK11770
693979004450	Domain of unknown function (DUF307); Region: DUF307; pfam03733
693979004451	Domain of unknown function (DUF307); Region: DUF307; pfam03733
693979004452	LytTr DNA-binding domain; Region: LytTR; smart00850
693979004453	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004454	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
693979004455	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
693979004456	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
693979004457	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
693979004458	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
693979004459	phosphodiesterase; Provisional; Region: PRK12704
693979004460	Plant protein of unknown function (DUF641); Region: DUF641; pfam04859
693979004461	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693979004462	Zn2+ binding site [ion binding]; other site
693979004463	Mg2+ binding site [ion binding]; other site
693979004464	Cell division protein ZapA; Region: ZapA; pfam05164
693979004465	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
693979004466	Transcriptional regulators [Transcription]; Region: MarR; COG1846
693979004467	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
693979004468	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
693979004469	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
693979004470	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
693979004471	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979004472	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
693979004473	DNA binding residues [nucleotide binding]
693979004474	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164
693979004475	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
693979004476	Protein of unknown function (DUF454); Region: DUF454; pfam04304
693979004477	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
693979004478	dimer interface [polypeptide binding]; other site
693979004479	pyridoxal binding site [chemical binding]; other site
693979004480	ATP binding site [chemical binding]; other site
693979004481	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
693979004482	active site
693979004483	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
693979004484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979004485	FeS/SAM binding site; other site
693979004486	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
693979004487	putative active site [active]
693979004488	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
693979004489	Protein of unknown function, DUF399; Region: DUF399; pfam04187
693979004490	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979004491	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979004492	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979004493	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979004494	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979004495	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979004496	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004497	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004498	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979004499	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004500	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979004501	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
693979004502	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979004503	FeS/SAM binding site; other site
693979004504	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
693979004505	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
693979004506	N-acetyl-D-glucosamine binding site [chemical binding]; other site
693979004507	catalytic residue [active]
693979004508	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
693979004509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979004510	NAD(P) binding site [chemical binding]; other site
693979004511	active site
693979004512	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
693979004513	putative active site [active]
693979004514	putative catalytic site [active]
693979004515	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
693979004516	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
693979004517	DNA binding site [nucleotide binding]
693979004518	active site
693979004519	endonuclease IV; Provisional; Region: PRK01060
693979004520	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
693979004521	AP (apurinic/apyrimidinic) site pocket; other site
693979004522	DNA interaction; other site
693979004523	Metal-binding active site; metal-binding site
693979004524	hypothetical protein; Provisional; Region: PRK10410
693979004525	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
693979004526	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979004527	Coenzyme A binding pocket [chemical binding]; other site
693979004528	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
693979004529	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
693979004530	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
693979004531	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693979004532	active site
693979004533	Peptidase family M48; Region: Peptidase_M48; pfam01435
693979004534	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
693979004535	nucleoside/Zn binding site; other site
693979004536	dimer interface [polypeptide binding]; other site
693979004537	catalytic motif [active]
693979004538	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
693979004539	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
693979004540	dimer interface [polypeptide binding]; other site
693979004541	active site
693979004542	CoA binding pocket [chemical binding]; other site
693979004543	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693979004544	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
693979004545	Sulfatase; Region: Sulfatase; cl17466
693979004546	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979004547	Two component regulator propeller; Region: Reg_prop; pfam07494
693979004548	Two component regulator propeller; Region: Reg_prop; pfam07494
693979004549	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979004550	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979004551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979004552	dimer interface [polypeptide binding]; other site
693979004553	phosphorylation site [posttranslational modification]
693979004554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979004555	ATP binding site [chemical binding]; other site
693979004556	Mg2+ binding site [ion binding]; other site
693979004557	G-X-G motif; other site
693979004558	Response regulator receiver domain; Region: Response_reg; pfam00072
693979004559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979004560	active site
693979004561	phosphorylation site [posttranslational modification]
693979004562	intermolecular recognition site; other site
693979004563	dimerization interface [polypeptide binding]; other site
693979004564	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979004565	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004566	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
693979004567	active site
693979004568	catalytic residues [active]
693979004569	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
693979004570	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004571	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004572	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979004573	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004574	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979004575	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
693979004576	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352
693979004577	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
693979004578	Sulfatase; Region: Sulfatase; cl17466
693979004579	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979004580	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693979004581	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
693979004582	nucleotide binding site [chemical binding]; other site
693979004583	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693979004584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979004585	putative substrate translocation pore; other site
693979004586	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
693979004587	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979004588	Sulfatase; Region: Sulfatase; cl17466
693979004589	SIR2-like domain; Region: SIR2_2; pfam13289
693979004590	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
693979004591	active site
693979004592	catalytic residues [active]
693979004593	DNA binding site [nucleotide binding]
693979004594	Int/Topo IB signature motif; other site
693979004595	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
693979004596	active site
693979004597	catalytic residues [active]
693979004598	DNA binding site [nucleotide binding]
693979004599	Int/Topo IB signature motif; other site
693979004600	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979004601	active site
693979004602	Int/Topo IB signature motif; other site
693979004603	DNA binding site [nucleotide binding]
693979004604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979004605	non-specific DNA binding site [nucleotide binding]; other site
693979004606	salt bridge; other site
693979004607	sequence-specific DNA binding site [nucleotide binding]; other site
693979004608	HipA N-terminal domain; Region: Couple_hipA; cl11853
693979004609	HipA-like N-terminal domain; Region: HipA_N; pfam07805
693979004610	HipA-like C-terminal domain; Region: HipA_C; pfam07804
693979004611	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
693979004612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979004613	non-specific DNA binding site [nucleotide binding]; other site
693979004614	salt bridge; other site
693979004615	sequence-specific DNA binding site [nucleotide binding]; other site
693979004616	Protein of unknown function DUF45; Region: DUF45; pfam01863
693979004617	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
693979004618	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
693979004619	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979004620	ATP binding site [chemical binding]; other site
693979004621	putative Mg++ binding site [ion binding]; other site
693979004622	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
693979004623	HsdM N-terminal domain; Region: HsdM_N; pfam12161
693979004624	Methyltransferase domain; Region: Methyltransf_26; pfam13659
693979004625	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
693979004626	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
693979004627	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
693979004628	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
693979004629	active site
693979004630	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
693979004631	FIC domain binding interface [polypeptide binding]; other site
693979004632	Fic/DOC family; Region: Fic; pfam02661
693979004633	Uncharacterized conserved protein [Function unknown]; Region: COG1479
693979004634	Protein of unknown function DUF262; Region: DUF262; pfam03235
693979004635	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
693979004636	Uncharacterized conserved protein [Function unknown]; Region: COG1479
693979004637	Protein of unknown function DUF262; Region: DUF262; pfam03235
693979004638	Archaeal ATPase; Region: Arch_ATPase; pfam01637
693979004639	AAA domain; Region: AAA_14; pfam13173
693979004640	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
693979004641	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
693979004642	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979004643	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
693979004644	Int/Topo IB signature motif; other site
693979004645	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979004646	Helix-turn-helix domain; Region: HTH_17; cl17695
693979004647	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
693979004648	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
693979004649	trmE is a tRNA modification GTPase; Region: trmE; cd04164
693979004650	G1 box; other site
693979004651	GTP/Mg2+ binding site [chemical binding]; other site
693979004652	Switch I region; other site
693979004653	G2 box; other site
693979004654	Switch II region; other site
693979004655	G3 box; other site
693979004656	G4 box; other site
693979004657	G5 box; other site
693979004658	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
693979004659	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
693979004660	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
693979004661	hypothetical protein; Provisional; Region: PRK13665
693979004662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979004663	binding surface
693979004664	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979004665	TPR motif; other site
693979004666	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
693979004667	Ligand Binding Site [chemical binding]; other site
693979004668	TIGR00269 family protein; Region: TIGR00269
693979004669	Protein of unknown function, DUF486; Region: DUF486; cl01236
693979004670	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
693979004671	ApbE family; Region: ApbE; pfam02424
693979004672	Predicted membrane protein [Function unknown]; Region: COG1971
693979004673	Domain of unknown function DUF; Region: DUF204; pfam02659
693979004674	Domain of unknown function DUF; Region: DUF204; pfam02659
693979004675	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
693979004676	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
693979004677	Ligand binding site; other site
693979004678	Putative Catalytic site; other site
693979004679	DXD motif; other site
693979004680	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
693979004681	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979004682	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
693979004683	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004684	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004685	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979004686	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004687	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979004688	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979004689	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979004690	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
693979004691	active site
693979004692	catalytic residues [active]
693979004693	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
693979004694	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
693979004695	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
693979004696	enolase; Provisional; Region: eno; PRK00077
693979004697	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
693979004698	dimer interface [polypeptide binding]; other site
693979004699	metal binding site [ion binding]; metal-binding site
693979004700	substrate binding pocket [chemical binding]; other site
693979004701	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
693979004702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979004703	binding surface
693979004704	TPR motif; other site
693979004705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979004706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979004707	dimer interface [polypeptide binding]; other site
693979004708	phosphorylation site [posttranslational modification]
693979004709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979004710	ATP binding site [chemical binding]; other site
693979004711	Mg2+ binding site [ion binding]; other site
693979004712	G-X-G motif; other site
693979004713	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
693979004714	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
693979004715	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
693979004716	active site
693979004717	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979004718	active site
693979004719	peptidase T; Region: peptidase-T; TIGR01882
693979004720	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
693979004721	metal binding site [ion binding]; metal-binding site
693979004722	dimer interface [polypeptide binding]; other site
693979004723	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
693979004724	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
693979004725	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
693979004726	Transglycosylase; Region: Transgly; pfam00912
693979004727	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
693979004728	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
693979004729	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
693979004730	putative catalytic site [active]
693979004731	putative metal binding site [ion binding]; other site
693979004732	putative phosphate binding site [ion binding]; other site
693979004733	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
693979004734	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
693979004735	intersubunit interface [polypeptide binding]; other site
693979004736	active site
693979004737	zinc binding site [ion binding]; other site
693979004738	Na+ binding site [ion binding]; other site
693979004739	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
693979004740	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
693979004741	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
693979004742	Ca binding site [ion binding]; other site
693979004743	active site
693979004744	homodimer interface [polypeptide binding]; other site
693979004745	catalytic site [active]
693979004746	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
693979004747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979004748	binding surface
693979004749	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979004750	TPR motif; other site
693979004751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979004752	binding surface
693979004753	TPR motif; other site
693979004754	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
693979004755	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693979004756	carboxyltransferase (CT) interaction site; other site
693979004757	biotinylation site [posttranslational modification]; other site
693979004758	Lamin Tail Domain; Region: LTD; pfam00932
693979004759	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
693979004760	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
693979004761	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
693979004762	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
693979004763	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693979004764	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
693979004765	dimer interface [polypeptide binding]; other site
693979004766	substrate binding site [chemical binding]; other site
693979004767	metal binding site [ion binding]; metal-binding site
693979004768	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
693979004769	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979004770	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979004771	ligand binding site [chemical binding]; other site
693979004772	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
693979004773	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
693979004774	TrkA-C domain; Region: TrkA_C; pfam02080
693979004775	TrkA-C domain; Region: TrkA_C; pfam02080
693979004776	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
693979004777	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
693979004778	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
693979004779	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693979004780	RNA binding surface [nucleotide binding]; other site
693979004781	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
693979004782	putative active site [active]
693979004783	catalytic residue [active]
693979004784	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
693979004785	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
693979004786	5S rRNA interface [nucleotide binding]; other site
693979004787	CTC domain interface [polypeptide binding]; other site
693979004788	L16 interface [polypeptide binding]; other site
693979004789	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
693979004790	transcription antitermination factor NusB; Region: nusB; TIGR01951
693979004791	Preprotein translocase subunit; Region: YajC; pfam02699
693979004792	YbbR-like protein; Region: YbbR; pfam07949
693979004793	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
693979004794	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
693979004795	CoA-binding site [chemical binding]; other site
693979004796	ATP-binding [chemical binding]; other site
693979004797	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
693979004798	Clp amino terminal domain; Region: Clp_N; pfam02861
693979004799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979004800	Walker A motif; other site
693979004801	ATP binding site [chemical binding]; other site
693979004802	Walker B motif; other site
693979004803	arginine finger; other site
693979004804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979004805	Walker A motif; other site
693979004806	ATP binding site [chemical binding]; other site
693979004807	Walker B motif; other site
693979004808	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
693979004809	Transcriptional regulator [Transcription]; Region: LysR; COG0583
693979004810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
693979004811	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
693979004812	putative dimerization interface [polypeptide binding]; other site
693979004813	Predicted membrane protein [Function unknown]; Region: COG2855
693979004814	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979004815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
693979004816	non-specific DNA binding site [nucleotide binding]; other site
693979004817	salt bridge; other site
693979004818	sequence-specific DNA binding site [nucleotide binding]; other site
693979004819	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
693979004820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979004821	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979004822	DNA binding residues [nucleotide binding]
693979004823	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
693979004824	recombinase A; Provisional; Region: recA; PRK09354
693979004825	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
693979004826	hexamer interface [polypeptide binding]; other site
693979004827	Walker A motif; other site
693979004828	ATP binding site [chemical binding]; other site
693979004829	Walker B motif; other site
693979004830	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
693979004831	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
693979004832	catalytic triad [active]
693979004833	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
693979004834	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
693979004835	META domain; Region: META; pfam03724
693979004836	META domain; Region: META; pfam03724
693979004837	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979004838	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693979004839	ligand binding site [chemical binding]; other site
693979004840	flexible hinge region; other site
693979004841	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979004842	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
693979004843	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
693979004844	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
693979004845	nucleotide binding site [chemical binding]; other site
693979004846	NEF interaction site [polypeptide binding]; other site
693979004847	SBD interface [polypeptide binding]; other site
693979004848	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
693979004849	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979004850	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979004851	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979004852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979004853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979004854	DNA binding residues [nucleotide binding]
693979004855	Transposase; Region: DEDD_Tnp_IS110; pfam01548
693979004856	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979004857	FecR protein; Region: FecR; pfam04773
693979004858	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979004859	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004860	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979004861	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004862	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
693979004863	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979004864	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
693979004865	active site
693979004866	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
693979004867	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
693979004868	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979004869	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979004870	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
693979004871	ligand binding site [chemical binding]; other site
693979004872	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979004873	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979004874	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979004875	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979004876	active site
693979004877	DNA binding site [nucleotide binding]
693979004878	Int/Topo IB signature motif; other site
693979004879	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979004880	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979004881	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
693979004882	AAA ATPase domain; Region: AAA_16; pfam13191
693979004883	Archaeal ATPase; Region: Arch_ATPase; pfam01637
693979004884	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
693979004885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979004886	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
693979004887	active site
693979004888	motif I; other site
693979004889	motif II; other site
693979004890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979004891	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
693979004892	CoenzymeA binding site [chemical binding]; other site
693979004893	subunit interaction site [polypeptide binding]; other site
693979004894	PHB binding site; other site
693979004895	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
693979004896	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979004897	Uncharacterized conserved protein [Function unknown]; Region: COG3391
693979004898	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
693979004899	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
693979004900	intersubunit interface [polypeptide binding]; other site
693979004901	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
693979004902	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
693979004903	ABC-ATPase subunit  interface; other site
693979004904	dimer interface [polypeptide binding]; other site
693979004905	putative PBP binding regions; other site
693979004906	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
693979004907	active site
693979004908	catalytic residues [active]
693979004909	DNA binding site [nucleotide binding]
693979004910	Int/Topo IB signature motif; other site
693979004911	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004912	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979004913	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
693979004914	FecR protein; Region: FecR; pfam04773
693979004915	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
693979004916	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979004917	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
693979004918	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
693979004919	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
693979004920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693979004921	catalytic residue [active]
693979004922	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
693979004923	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
693979004924	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
693979004925	TrkA-N domain; Region: TrkA_N; pfam02254
693979004926	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979004927	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979004928	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
693979004929	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
693979004930	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
693979004931	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
693979004932	MutS domain III; Region: MutS_III; pfam05192
693979004933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979004934	Walker A/P-loop; other site
693979004935	ATP binding site [chemical binding]; other site
693979004936	Q-loop/lid; other site
693979004937	ABC transporter signature motif; other site
693979004938	Walker B; other site
693979004939	D-loop; other site
693979004940	H-loop/switch region; other site
693979004941	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
693979004942	Smr domain; Region: Smr; pfam01713
693979004943	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979004944	Int/Topo IB signature motif; other site
693979004945	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979004946	comF family protein; Region: comF; TIGR00201
693979004947	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979004948	active site
693979004949	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
693979004950	GIY-YIG motif/motif A; other site
693979004951	active site
693979004952	catalytic site [active]
693979004953	metal binding site [ion binding]; metal-binding site
693979004954	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
693979004955	GIY-YIG motif/motif A; other site
693979004956	active site
693979004957	catalytic site [active]
693979004958	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979004959	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979004960	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979004961	PcfK-like protein; Region: PcfK; pfam14058
693979004962	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
693979004963	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979004964	non-specific DNA binding site [nucleotide binding]; other site
693979004965	salt bridge; other site
693979004966	sequence-specific DNA binding site [nucleotide binding]; other site
693979004967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
693979004968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979004969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979004970	ATP binding site [chemical binding]; other site
693979004971	Mg2+ binding site [ion binding]; other site
693979004972	G-X-G motif; other site
693979004973	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
693979004974	active site
693979004975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979004976	S-adenosylmethionine binding site [chemical binding]; other site
693979004977	NigD-like protein; Region: NigD; pfam12667
693979004978	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979004979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979004980	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979004981	DNA binding residues [nucleotide binding]
693979004982	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979004983	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
693979004984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979004985	FeS/SAM binding site; other site
693979004986	Pyruvate formate lyase 1; Region: PFL1; cd01678
693979004987	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
693979004988	coenzyme A binding site [chemical binding]; other site
693979004989	active site
693979004990	catalytic residues [active]
693979004991	glycine loop; other site
693979004992	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979004993	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979004994	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979004995	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979004996	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979004997	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979004998	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979004999	Tandemly repeated domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like; cl17916
693979005000	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979005001	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
693979005002	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979005003	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979005004	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979005005	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
693979005006	RteC protein; Region: RteC; pfam09357
693979005007	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
693979005008	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
693979005009	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
693979005010	DNA methylase; Region: N6_N4_Mtase; pfam01555
693979005011	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
693979005012	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
693979005013	putative active site [active]
693979005014	putative metal binding site [ion binding]; other site
693979005015	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
693979005016	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
693979005017	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
693979005018	homodimer interface [polypeptide binding]; other site
693979005019	NADP binding site [chemical binding]; other site
693979005020	substrate binding site [chemical binding]; other site
693979005021	signal recognition particle protein; Provisional; Region: PRK10867
693979005022	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
693979005023	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
693979005024	P loop; other site
693979005025	GTP binding site [chemical binding]; other site
693979005026	Signal peptide binding domain; Region: SRP_SPB; pfam02978
693979005027	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
693979005028	transcription termination factor Rho; Provisional; Region: PRK12608
693979005029	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
693979005030	RNA binding site [nucleotide binding]; other site
693979005031	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
693979005032	multimer interface [polypeptide binding]; other site
693979005033	Walker A motif; other site
693979005034	ATP binding site [chemical binding]; other site
693979005035	Walker B motif; other site
693979005036	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
693979005037	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
693979005038	Ligand Binding Site [chemical binding]; other site
693979005039	TilS substrate C-terminal domain; Region: TilS_C; smart00977
693979005040	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
693979005041	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
693979005042	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
693979005043	G1 box; other site
693979005044	GTP/Mg2+ binding site [chemical binding]; other site
693979005045	Switch I region; other site
693979005046	G2 box; other site
693979005047	G3 box; other site
693979005048	Switch II region; other site
693979005049	G4 box; other site
693979005050	G5 box; other site
693979005051	Nucleoside recognition; Region: Gate; pfam07670
693979005052	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
693979005053	Nucleoside recognition; Region: Gate; pfam07670
693979005054	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979005055	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979005056	catalytic residues [active]
693979005057	Methyltransferase domain; Region: Methyltransf_23; pfam13489
693979005058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979005059	S-adenosylmethionine binding site [chemical binding]; other site
693979005060	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
693979005061	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
693979005062	dimer interface [polypeptide binding]; other site
693979005063	active site
693979005064	metal binding site [ion binding]; metal-binding site
693979005065	glutathione binding site [chemical binding]; other site
693979005066	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
693979005067	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
693979005068	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
693979005069	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
693979005070	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
693979005071	putative ligand binding site [chemical binding]; other site
693979005072	putative NAD binding site [chemical binding]; other site
693979005073	catalytic site [active]
693979005074	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
693979005075	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
693979005076	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
693979005077	Ligand Binding Site [chemical binding]; other site
693979005078	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
693979005079	enolase; Provisional; Region: eno; PRK00077
693979005080	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
693979005081	dimer interface [polypeptide binding]; other site
693979005082	metal binding site [ion binding]; metal-binding site
693979005083	substrate binding pocket [chemical binding]; other site
693979005084	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
693979005085	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
693979005086	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979005087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979005088	N-terminal plug; other site
693979005089	ligand-binding site [chemical binding]; other site
693979005090	Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696
693979005091	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
693979005092	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979005093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
693979005094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979005095	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
693979005096	Walker A/P-loop; other site
693979005097	ATP binding site [chemical binding]; other site
693979005098	Q-loop/lid; other site
693979005099	ABC transporter signature motif; other site
693979005100	Walker B; other site
693979005101	D-loop; other site
693979005102	H-loop/switch region; other site
693979005103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979005104	S-adenosylmethionine binding site [chemical binding]; other site
693979005105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
693979005106	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
693979005107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979005108	Walker A/P-loop; other site
693979005109	ATP binding site [chemical binding]; other site
693979005110	Q-loop/lid; other site
693979005111	ABC transporter signature motif; other site
693979005112	Walker B; other site
693979005113	D-loop; other site
693979005114	H-loop/switch region; other site
693979005115	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
693979005116	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
693979005117	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979005118	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
693979005119	ligand binding site [chemical binding]; other site
693979005120	flexible hinge region; other site
693979005121	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
693979005122	hybrid cluster protein; Provisional; Region: PRK05290
693979005123	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979005124	ACS interaction site; other site
693979005125	CODH interaction site; other site
693979005126	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
693979005127	hybrid metal cluster; other site
693979005128	Ribokinase-like subgroup D.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937
693979005129	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693979005130	substrate binding site [chemical binding]; other site
693979005131	ATP binding site [chemical binding]; other site
693979005132	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
693979005133	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
693979005134	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
693979005135	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
693979005136	TPP-binding site; other site
693979005137	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
693979005138	PYR/PP interface [polypeptide binding]; other site
693979005139	dimer interface [polypeptide binding]; other site
693979005140	TPP binding site [chemical binding]; other site
693979005141	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693979005142	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979005143	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979005144	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
693979005145	FecR protein; Region: FecR; pfam04773
693979005146	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979005147	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979005148	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979005149	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979005150	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
693979005151	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979005152	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
693979005153	active site
693979005154	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
693979005155	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
693979005156	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979005157	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
693979005158	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
693979005159	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
693979005160	putative active site [active]
693979005161	putative substrate binding site [chemical binding]; other site
693979005162	putative cosubstrate binding site; other site
693979005163	catalytic site [active]
693979005164	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
693979005165	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
693979005166	putative active site [active]
693979005167	oxyanion strand; other site
693979005168	catalytic triad [active]
693979005169	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
693979005170	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
693979005171	catalytic residues [active]
693979005172	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
693979005173	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
693979005174	substrate binding site [chemical binding]; other site
693979005175	glutamase interaction surface [polypeptide binding]; other site
693979005176	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
693979005177	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
693979005178	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
693979005179	metal binding site [ion binding]; metal-binding site
693979005180	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979005181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979005182	Walker A/P-loop; other site
693979005183	ATP binding site [chemical binding]; other site
693979005184	Q-loop/lid; other site
693979005185	ABC transporter signature motif; other site
693979005186	Walker B; other site
693979005187	D-loop; other site
693979005188	H-loop/switch region; other site
693979005189	aspartate kinase III; Validated; Region: PRK09084
693979005190	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
693979005191	putative catalytic residues [active]
693979005192	nucleotide binding site [chemical binding]; other site
693979005193	aspartate binding site [chemical binding]; other site
693979005194	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
693979005195	dimer interface [polypeptide binding]; other site
693979005196	allosteric regulatory binding pocket; other site
693979005197	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
693979005198	dimer interface [polypeptide binding]; other site
693979005199	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
693979005200	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
693979005201	active site
693979005202	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693979005203	substrate binding site [chemical binding]; other site
693979005204	catalytic residues [active]
693979005205	dimer interface [polypeptide binding]; other site
693979005206	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
693979005207	Ferritin-like domain; Region: Ferritin; pfam00210
693979005208	ferroxidase diiron center [ion binding]; other site
693979005209	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
693979005210	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
693979005211	substrate-cofactor binding pocket; other site
693979005212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005213	catalytic residue [active]
693979005214	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979005215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005216	NAD(P) binding site [chemical binding]; other site
693979005217	active site
693979005218	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
693979005219	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
693979005220	FAD binding domain; Region: FAD_binding_4; pfam01565
693979005221	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
693979005222	putative hydrolase; Provisional; Region: PRK02113
693979005223	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
693979005224	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
693979005225	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
693979005226	DNA polymerase III subunit beta; Validated; Region: PRK05643
693979005227	putative DNA binding surface [nucleotide binding]; other site
693979005228	dimer interface [polypeptide binding]; other site
693979005229	beta-clamp/translesion DNA polymerase binding surface; other site
693979005230	beta-clamp/clamp loader binding surface; other site
693979005231	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
693979005232	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
693979005233	active site
693979005234	catalytic site [active]
693979005235	substrate binding site [chemical binding]; other site
693979005236	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
693979005237	Flavoprotein; Region: Flavoprotein; pfam02441
693979005238	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
693979005239	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
693979005240	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
693979005241	Walker A/P-loop; other site
693979005242	ATP binding site [chemical binding]; other site
693979005243	Q-loop/lid; other site
693979005244	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
693979005245	ABC transporter signature motif; other site
693979005246	Walker B; other site
693979005247	D-loop; other site
693979005248	H-loop/switch region; other site
693979005249	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693979005250	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
693979005251	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
693979005252	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
693979005253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
693979005254	TPR motif; other site
693979005255	binding surface
693979005256	TPR repeat; Region: TPR_11; pfam13414
693979005257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979005258	binding surface
693979005259	TPR motif; other site
693979005260	TPR repeat; Region: TPR_11; pfam13414
693979005261	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
693979005262	homotrimer interaction site [polypeptide binding]; other site
693979005263	putative active site [active]
693979005264	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
693979005265	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
693979005266	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
693979005267	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
693979005268	putative active site [active]
693979005269	PhoH-like protein; Region: PhoH; pfam02562
693979005270	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
693979005271	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
693979005272	NAD(P) binding site [chemical binding]; other site
693979005273	homodimer interface [polypeptide binding]; other site
693979005274	substrate binding site [chemical binding]; other site
693979005275	active site
693979005276	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
693979005277	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
693979005278	phosphate binding site [ion binding]; other site
693979005279	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
693979005280	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693979005281	catalytic residue [active]
693979005282	multiple promoter invertase; Provisional; Region: mpi; PRK13413
693979005283	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
693979005284	catalytic residues [active]
693979005285	catalytic nucleophile [active]
693979005286	Presynaptic Site I dimer interface [polypeptide binding]; other site
693979005287	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
693979005288	Synaptic Flat tetramer interface [polypeptide binding]; other site
693979005289	Synaptic Site I dimer interface [polypeptide binding]; other site
693979005290	DNA binding site [nucleotide binding]
693979005291	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
693979005292	DNA-binding interface [nucleotide binding]; DNA binding site
693979005293	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
693979005294	dimer interface [polypeptide binding]; other site
693979005295	catalytic triad [active]
693979005296	peroxidatic and resolving cysteines [active]
693979005297	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
693979005298	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
693979005299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979005300	TPR motif; other site
693979005301	binding surface
693979005302	TPR repeat; Region: TPR_11; pfam13414
693979005303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979005304	binding surface
693979005305	TPR motif; other site
693979005306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979005307	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
693979005308	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979005309	active site
693979005310	HIGH motif; other site
693979005311	nucleotide binding site [chemical binding]; other site
693979005312	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979005313	active site
693979005314	KMSKS motif; other site
693979005315	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
693979005316	PBP superfamily domain; Region: PBP_like_2; cl17296
693979005317	PBP superfamily domain; Region: PBP_like_2; cl17296
693979005318	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
693979005319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
693979005320	dimer interface [polypeptide binding]; other site
693979005321	conserved gate region; other site
693979005322	putative PBP binding loops; other site
693979005323	ABC-ATPase subunit interface; other site
693979005324	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
693979005325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
693979005326	dimer interface [polypeptide binding]; other site
693979005327	conserved gate region; other site
693979005328	putative PBP binding loops; other site
693979005329	ABC-ATPase subunit interface; other site
693979005330	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
693979005331	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
693979005332	Walker A/P-loop; other site
693979005333	ATP binding site [chemical binding]; other site
693979005334	Q-loop/lid; other site
693979005335	ABC transporter signature motif; other site
693979005336	Walker B; other site
693979005337	D-loop; other site
693979005338	H-loop/switch region; other site
693979005339	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
693979005340	PhoU domain; Region: PhoU; pfam01895
693979005341	PhoU domain; Region: PhoU; pfam01895
693979005342	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
693979005343	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
693979005344	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979005345	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979005346	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
693979005347	OmpA family; Region: OmpA; pfam00691
693979005348	ligand binding site [chemical binding]; other site
693979005349	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979005350	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979005351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979005352	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
693979005353	Response regulator receiver domain; Region: Response_reg; pfam00072
693979005354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979005355	active site
693979005356	phosphorylation site [posttranslational modification]
693979005357	intermolecular recognition site; other site
693979005358	dimerization interface [polypeptide binding]; other site
693979005359	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979005360	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
693979005361	Lumazine binding domain; Region: Lum_binding; pfam00677
693979005362	Lumazine binding domain; Region: Lum_binding; pfam00677
693979005363	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
693979005364	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
693979005365	NlpC/P60 family; Region: NLPC_P60; pfam00877
693979005366	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
693979005367	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
693979005368	active site
693979005369	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
693979005370	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
693979005371	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
693979005372	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
693979005373	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
693979005374	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
693979005375	protein binding site [polypeptide binding]; other site
693979005376	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
693979005377	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
693979005378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979005379	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
693979005380	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979005381	DNA binding residues [nucleotide binding]
693979005382	Clostripain family; Region: Peptidase_C11; pfam03415
693979005383	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
693979005384	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
693979005385	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979005386	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693979005387	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
693979005388	active site residue [active]
693979005389	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
693979005390	CPxP  motif; other site
693979005391	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
693979005392	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
693979005393	active site
693979005394	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979005395	MarR family; Region: MarR; pfam01047
693979005396	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979005397	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979005398	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
693979005399	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
693979005400	NAD(P) binding site [chemical binding]; other site
693979005401	homodimer interface [polypeptide binding]; other site
693979005402	substrate binding site [chemical binding]; other site
693979005403	active site
693979005404	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
693979005405	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693979005406	inhibitor-cofactor binding pocket; inhibition site
693979005407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005408	catalytic residue [active]
693979005409	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
693979005410	ligand binding site; other site
693979005411	tetramer interface; other site
693979005412	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
693979005413	active site
693979005414	NTP binding site [chemical binding]; other site
693979005415	metal binding triad [ion binding]; metal-binding site
693979005416	antibiotic binding site [chemical binding]; other site
693979005417	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
693979005418	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979005419	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
693979005420	active site
693979005421	substrate binding site [chemical binding]; other site
693979005422	cosubstrate binding site; other site
693979005423	catalytic site [active]
693979005424	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
693979005425	ATP-grasp domain; Region: ATP-grasp_4; cl17255
693979005426	Uncharacterized membrane protein [Function unknown]; Region: COG3949
693979005427	pseudaminic acid synthase; Region: PseI; TIGR03586
693979005428	NeuB family; Region: NeuB; pfam03102
693979005429	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
693979005430	NeuB binding interface [polypeptide binding]; other site
693979005431	putative substrate binding site [chemical binding]; other site
693979005432	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
693979005433	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
693979005434	amidase catalytic site [active]
693979005435	Zn binding residues [ion binding]; other site
693979005436	substrate binding site [chemical binding]; other site
693979005437	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979005438	Domain of unknown function (DUF4248); Region: DUF4248; pfam14053
693979005439	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
693979005440	VirE N-terminal domain; Region: VirE_N; pfam08800
693979005441	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
693979005442	active site
693979005443	NTP binding site [chemical binding]; other site
693979005444	metal binding triad [ion binding]; metal-binding site
693979005445	antibiotic binding site [chemical binding]; other site
693979005446	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979005447	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979005448	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979005449	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979005450	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979005451	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979005452	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
693979005453	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
693979005454	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979005455	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
693979005456	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
693979005457	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
693979005458	substrate binding site; other site
693979005459	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
693979005460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005461	NAD(P) binding site [chemical binding]; other site
693979005462	active site
693979005463	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
693979005464	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979005465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005466	NAD(P) binding site [chemical binding]; other site
693979005467	active site
693979005468	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979005469	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005470	active site
693979005471	Acyltransferase family; Region: Acyl_transf_3; pfam01757
693979005472	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
693979005473	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979005474	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
693979005475	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
693979005476	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979005477	putative ADP-binding pocket [chemical binding]; other site
693979005478	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
693979005479	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979005480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005481	NAD(P) binding site [chemical binding]; other site
693979005482	active site
693979005483	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
693979005484	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
693979005485	Mg++ binding site [ion binding]; other site
693979005486	putative catalytic motif [active]
693979005487	putative substrate binding site [chemical binding]; other site
693979005488	bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412
693979005489	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
693979005490	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
693979005491	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
693979005492	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
693979005493	dimerization interface [polypeptide binding]; other site
693979005494	active site
693979005495	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979005496	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979005497	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
693979005498	DNA binding residues [nucleotide binding]
693979005499	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979005500	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
693979005501	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
693979005502	FMN binding site [chemical binding]; other site
693979005503	substrate binding site [chemical binding]; other site
693979005504	putative catalytic residue [active]
693979005505	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
693979005506	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
693979005507	hexamer interface [polypeptide binding]; other site
693979005508	ligand binding site [chemical binding]; other site
693979005509	putative active site [active]
693979005510	NAD(P) binding site [chemical binding]; other site
693979005511	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
693979005512	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979005513	Peptidase family C69; Region: Peptidase_C69; cl17793
693979005514	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
693979005515	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
693979005516	active site
693979005517	substrate binding site [chemical binding]; other site
693979005518	metal binding site [ion binding]; metal-binding site
693979005519	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
693979005520	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
693979005521	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
693979005522	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
693979005523	putative NADH binding site [chemical binding]; other site
693979005524	putative active site [active]
693979005525	nudix motif; other site
693979005526	putative metal binding site [ion binding]; other site
693979005527	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
693979005528	Asp-box motif; other site
693979005529	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979005530	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
693979005531	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
693979005532	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
693979005533	metal ion-dependent adhesion site (MIDAS); other site
693979005534	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
693979005535	active site
693979005536	catalytic motif [active]
693979005537	Zn binding site [ion binding]; other site
693979005538	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
693979005539	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979005540	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
693979005541	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979005542	V-type ATP synthase subunit E; Provisional; Region: PRK01558
693979005543	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
693979005544	V-type ATP synthase subunit A; Provisional; Region: PRK04192
693979005545	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
693979005546	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
693979005547	Walker A motif/ATP binding site; other site
693979005548	Walker B motif; other site
693979005549	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
693979005550	V-type ATP synthase subunit B; Provisional; Region: PRK02118
693979005551	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
693979005552	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
693979005553	Walker A motif homologous position; other site
693979005554	Walker B motif; other site
693979005555	V-type ATP synthase subunit D; Provisional; Region: PRK02195
693979005556	V-type ATP synthase subunit I; Validated; Region: PRK05771
693979005557	ATP synthase subunit C; Region: ATP-synt_C; cl00466
693979005558	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
693979005559	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979005560	Glycogen synthase; Region: Glycogen_syn; pfam05693
693979005561	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
693979005562	putative homodimer interface [polypeptide binding]; other site
693979005563	putative active site pocket [active]
693979005564	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
693979005565	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
693979005566	flavodoxin FldA; Validated; Region: PRK09267
693979005567	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
693979005568	catalytic core [active]
693979005569	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
693979005570	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
693979005571	Uncharacterized conserved protein [Function unknown]; Region: COG2966
693979005572	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
693979005573	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
693979005574	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
693979005575	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
693979005576	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979005577	FeS/SAM binding site; other site
693979005578	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
693979005579	ATP cone domain; Region: ATP-cone; pfam03477
693979005580	Class III ribonucleotide reductase; Region: RNR_III; cd01675
693979005581	effector binding site; other site
693979005582	active site
693979005583	Zn binding site [ion binding]; other site
693979005584	glycine loop; other site
693979005585	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
693979005586	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979005587	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979005588	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979005589	catalytic residues [active]
693979005590	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
693979005591	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
693979005592	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
693979005593	DNA binding site [nucleotide binding]
693979005594	domain linker motif; other site
693979005595	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
693979005596	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
693979005597	ligand binding site [chemical binding]; other site
693979005598	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693979005599	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
693979005600	substrate binding site [chemical binding]; other site
693979005601	ATP binding site [chemical binding]; other site
693979005602	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
693979005603	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
693979005604	active site
693979005605	intersubunit interface [polypeptide binding]; other site
693979005606	catalytic residue [active]
693979005607	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979005608	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
693979005609	DXD motif; other site
693979005610	putative glycosyl transferase; Provisional; Region: PRK10073
693979005611	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005612	active site
693979005613	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979005614	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005615	active site
693979005616	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979005617	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
693979005618	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
693979005619	Probable Catalytic site; other site
693979005620	metal-binding site
693979005621	putative glycosyl transferase; Provisional; Region: PRK10073
693979005622	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005623	active site
693979005624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979005625	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979005626	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979005627	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
693979005628	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979005629	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
693979005630	DXD motif; other site
693979005631	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
693979005632	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
693979005633	Outer membrane efflux protein; Region: OEP; pfam02321
693979005634	Bacterial sugar transferase; Region: Bac_transf; pfam02397
693979005635	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
693979005636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979005637	active site
693979005638	phosphorylation site [posttranslational modification]
693979005639	intermolecular recognition site; other site
693979005640	dimerization interface [polypeptide binding]; other site
693979005641	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
693979005642	active site
693979005643	homodimer interface [polypeptide binding]; other site
693979005644	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
693979005645	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
693979005646	substrate binding site [chemical binding]; other site
693979005647	active site
693979005648	catalytic residues [active]
693979005649	heterodimer interface [polypeptide binding]; other site
693979005650	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
693979005651	active site
693979005652	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
693979005653	active site
693979005654	ribulose/triose binding site [chemical binding]; other site
693979005655	phosphate binding site [ion binding]; other site
693979005656	substrate (anthranilate) binding pocket [chemical binding]; other site
693979005657	product (indole) binding pocket [chemical binding]; other site
693979005658	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
693979005659	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
693979005660	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
693979005661	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
693979005662	Glutamine amidotransferase class-I; Region: GATase; pfam00117
693979005663	glutamine binding [chemical binding]; other site
693979005664	catalytic triad [active]
693979005665	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
693979005666	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
693979005667	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
693979005668	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
693979005669	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
693979005670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005671	catalytic residue [active]
693979005672	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
693979005673	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
693979005674	PS-10 peptidase S37; Region: Peptidase_S37; pfam05576
693979005675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979005676	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979005677	putative substrate translocation pore; other site
693979005678	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
693979005679	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
693979005680	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
693979005681	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
693979005682	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
693979005683	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
693979005684	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
693979005685	Nitrogen regulatory protein P-II; Region: P-II; smart00938
693979005686	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
693979005687	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979005688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005689	homodimer interface [polypeptide binding]; other site
693979005690	catalytic residue [active]
693979005691	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
693979005692	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
693979005693	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
693979005694	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979005695	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979005696	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005697	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005698	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979005699	FtsX-like permease family; Region: FtsX; pfam02687
693979005700	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979005701	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979005702	Walker A/P-loop; other site
693979005703	ATP binding site [chemical binding]; other site
693979005704	Q-loop/lid; other site
693979005705	ABC transporter signature motif; other site
693979005706	Walker B; other site
693979005707	D-loop; other site
693979005708	H-loop/switch region; other site
693979005709	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005710	FtsX-like permease family; Region: FtsX; pfam02687
693979005711	FtsX-like permease family; Region: FtsX; pfam02687
693979005712	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
693979005713	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005714	FtsX-like permease family; Region: FtsX; pfam02687
693979005715	FtsX-like permease family; Region: FtsX; pfam02687
693979005716	PAS domain; Region: PAS; smart00091
693979005717	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
693979005718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979005719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979005720	dimer interface [polypeptide binding]; other site
693979005721	phosphorylation site [posttranslational modification]
693979005722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979005723	ATP binding site [chemical binding]; other site
693979005724	Mg2+ binding site [ion binding]; other site
693979005725	G-X-G motif; other site
693979005726	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
693979005727	substrate binding site [chemical binding]; other site
693979005728	trimer interface [polypeptide binding]; other site
693979005729	hexamer (dimer of trimers) interface [polypeptide binding]; other site
693979005730	Mn binding site [ion binding]; other site
693979005731	aspartate aminotransferase; Provisional; Region: PRK07568
693979005732	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979005733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005734	homodimer interface [polypeptide binding]; other site
693979005735	catalytic residue [active]
693979005736	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
693979005737	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005738	FtsX-like permease family; Region: FtsX; pfam02687
693979005739	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
693979005740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979005741	active site
693979005742	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
693979005743	AAA domain; Region: AAA_26; pfam13500
693979005744	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
693979005745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979005746	S-adenosylmethionine binding site [chemical binding]; other site
693979005747	Protein of unknown function (DUF452); Region: DUF452; cl01062
693979005748	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
693979005749	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
693979005750	substrate-cofactor binding pocket; other site
693979005751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005752	catalytic residue [active]
693979005753	biotin synthase; Region: bioB; TIGR00433
693979005754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979005755	FeS/SAM binding site; other site
693979005756	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
693979005757	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
693979005758	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
693979005759	inhibitor-cofactor binding pocket; inhibition site
693979005760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005761	catalytic residue [active]
693979005762	asparagine synthetase B; Provisional; Region: asnB; PRK09431
693979005763	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
693979005764	active site
693979005765	dimer interface [polypeptide binding]; other site
693979005766	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
693979005767	Ligand Binding Site [chemical binding]; other site
693979005768	Molecular Tunnel; other site
693979005769	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
693979005770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
693979005771	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
693979005772	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
693979005773	active site
693979005774	dimer interface [polypeptide binding]; other site
693979005775	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
693979005776	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
693979005777	active site
693979005778	FMN binding site [chemical binding]; other site
693979005779	substrate binding site [chemical binding]; other site
693979005780	3Fe-4S cluster binding site [ion binding]; other site
693979005781	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
693979005782	domain interface; other site
693979005783	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
693979005784	active site
693979005785	amidophosphoribosyltransferase; Provisional; Region: PRK07272
693979005786	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
693979005787	active site
693979005788	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
693979005789	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
693979005790	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
693979005791	catalytic site [active]
693979005792	subunit interface [polypeptide binding]; other site
693979005793	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
693979005794	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693979005795	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
693979005796	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
693979005797	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693979005798	ATP-grasp domain; Region: ATP-grasp_4; cl17255
693979005799	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
693979005800	probable substrate binding site [chemical binding]; other site
693979005801	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
693979005802	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979005803	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979005804	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979005805	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979005806	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979005807	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979005808	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
693979005809	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979005810	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979005811	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
693979005812	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
693979005813	LicD family; Region: LicD; cl01378
693979005814	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979005815	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
693979005816	active site
693979005817	nucleotide binding site [chemical binding]; other site
693979005818	HIGH motif; other site
693979005819	KMSKS motif; other site
693979005820	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
693979005821	catalytic core [active]
693979005822	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
693979005823	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
693979005824	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
693979005825	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
693979005826	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
693979005827	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
693979005828	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
693979005829	putative glycosyl transferase; Provisional; Region: PRK10073
693979005830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005831	active site
693979005832	putative glycosyl transferase; Provisional; Region: PRK10073
693979005833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979005834	active site
693979005835	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979005836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979005837	active site
693979005838	Protein of unknown function (DUF3972); Region: DUF3972; pfam13118
693979005839	Bacterial sugar transferase; Region: Bac_transf; pfam02397
693979005840	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
693979005841	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693979005842	inhibitor-cofactor binding pocket; inhibition site
693979005843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979005844	catalytic residue [active]
693979005845	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979005846	excinuclease ABC subunit B; Provisional; Region: PRK05298
693979005847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979005848	ATP binding site [chemical binding]; other site
693979005849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979005850	nucleotide binding region [chemical binding]; other site
693979005851	ATP-binding site [chemical binding]; other site
693979005852	Ultra-violet resistance protein B; Region: UvrB; pfam12344
693979005853	UvrB/uvrC motif; Region: UVR; pfam02151
693979005854	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
693979005855	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979005856	acyl-activating enzyme (AAE) consensus motif; other site
693979005857	AMP binding site [chemical binding]; other site
693979005858	active site
693979005859	CoA binding site [chemical binding]; other site
693979005860	ACT domain-containing protein [General function prediction only]; Region: COG4747
693979005861	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
693979005862	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
693979005863	Outer membrane lipoprotein; Region: YfiO; pfam13525
693979005864	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
693979005865	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979005866	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979005867	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979005868	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
693979005869	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
693979005870	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
693979005871	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
693979005872	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
693979005873	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
693979005874	putative deacylase active site [active]
693979005875	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
693979005876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979005877	putative substrate translocation pore; other site
693979005878	POT family; Region: PTR2; cl17359
693979005879	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
693979005880	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979005881	Coenzyme A binding pocket [chemical binding]; other site
693979005882	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
693979005883	4Fe-4S binding domain; Region: Fer4; pfam00037
693979005884	4Fe-4S binding domain; Region: Fer4; pfam00037
693979005885	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
693979005886	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
693979005887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979005888	FeS/SAM binding site; other site
693979005889	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
693979005890	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
693979005891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979005892	FeS/SAM binding site; other site
693979005893	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
693979005894	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
693979005895	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
693979005896	G1 box; other site
693979005897	GTP/Mg2+ binding site [chemical binding]; other site
693979005898	Switch I region; other site
693979005899	G2 box; other site
693979005900	Switch II region; other site
693979005901	G3 box; other site
693979005902	G4 box; other site
693979005903	G5 box; other site
693979005904	Predicted transcriptional regulators [Transcription]; Region: COG1695
693979005905	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
693979005906	PspC domain; Region: PspC; pfam04024
693979005907	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979005908	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979005909	NeuB family; Region: NeuB; pfam03102
693979005910	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
693979005911	ligand binding site; other site
693979005912	tetramer interface; other site
693979005913	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
693979005914	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979005915	active site
693979005916	motif I; other site
693979005917	motif II; other site
693979005918	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979005919	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
693979005920	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
693979005921	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693979005922	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693979005923	catalytic residue [active]
693979005924	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
693979005925	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693979005926	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
693979005927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979005928	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
693979005929	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
693979005930	active site
693979005931	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979005932	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
693979005933	Probable Catalytic site; other site
693979005934	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979005935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005936	NAD(P) binding site [chemical binding]; other site
693979005937	active site
693979005938	putative glycosyl transferase; Provisional; Region: PRK10063
693979005939	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
693979005940	metal-binding site
693979005941	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
693979005942	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
693979005943	NADP-binding site; other site
693979005944	homotetramer interface [polypeptide binding]; other site
693979005945	substrate binding site [chemical binding]; other site
693979005946	homodimer interface [polypeptide binding]; other site
693979005947	active site
693979005948	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979005949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979005950	NAD(P) binding site [chemical binding]; other site
693979005951	active site
693979005952	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
693979005953	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
693979005954	Mg++ binding site [ion binding]; other site
693979005955	putative catalytic motif [active]
693979005956	putative substrate binding site [chemical binding]; other site
693979005957	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
693979005958	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
693979005959	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
693979005960	putative dimer interface [polypeptide binding]; other site
693979005961	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
693979005962	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693979005963	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979005964	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979005965	acyl-activating enzyme (AAE) consensus motif; other site
693979005966	acyl-activating enzyme (AAE) consensus motif; other site
693979005967	AMP binding site [chemical binding]; other site
693979005968	active site
693979005969	CoA binding site [chemical binding]; other site
693979005970	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
693979005971	TrkA-C domain; Region: TrkA_C; pfam02080
693979005972	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
693979005973	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979005974	ATP binding site [chemical binding]; other site
693979005975	Mg2+ binding site [ion binding]; other site
693979005976	G-X-G motif; other site
693979005977	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
693979005978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979005979	active site
693979005980	phosphorylation site [posttranslational modification]
693979005981	intermolecular recognition site; other site
693979005982	dimerization interface [polypeptide binding]; other site
693979005983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979005984	Walker A motif; other site
693979005985	ATP binding site [chemical binding]; other site
693979005986	Walker B motif; other site
693979005987	arginine finger; other site
693979005988	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979005989	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979005990	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
693979005991	active site
693979005992	metal binding site [ion binding]; metal-binding site
693979005993	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
693979005994	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005995	FtsX-like permease family; Region: FtsX; pfam02687
693979005996	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979005997	FtsX-like permease family; Region: FtsX; pfam02687
693979005998	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979005999	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979006000	Walker A/P-loop; other site
693979006001	ATP binding site [chemical binding]; other site
693979006002	Q-loop/lid; other site
693979006003	ABC transporter signature motif; other site
693979006004	Walker B; other site
693979006005	D-loop; other site
693979006006	H-loop/switch region; other site
693979006007	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979006008	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
693979006009	FtsX-like permease family; Region: FtsX; pfam02687
693979006010	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979006011	FtsX-like permease family; Region: FtsX; pfam02687
693979006012	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979006013	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
693979006014	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
693979006015	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
693979006016	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979006017	motif II; other site
693979006018	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
693979006019	oligomerization interface [polypeptide binding]; other site
693979006020	active site
693979006021	metal binding site [ion binding]; metal-binding site
693979006022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979006023	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979006024	putative substrate translocation pore; other site
693979006025	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
693979006026	HD domain; Region: HD_4; pfam13328
693979006027	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
693979006028	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
693979006029	synthetase active site [active]
693979006030	NTP binding site [chemical binding]; other site
693979006031	metal binding site [ion binding]; metal-binding site
693979006032	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
693979006033	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
693979006034	Inner membrane complex protein; Region: IMCp; pfam12314
693979006035	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979006036	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979006037	ligand binding site [chemical binding]; other site
693979006038	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
693979006039	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979006040	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
693979006041	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979006042	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
693979006043	active site
693979006044	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
693979006045	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
693979006046	ATP-grasp domain; Region: ATP-grasp; pfam02222
693979006047	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
693979006048	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
693979006049	replicative DNA helicase; Region: DnaB; TIGR00665
693979006050	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
693979006051	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
693979006052	Walker A motif; other site
693979006053	ATP binding site [chemical binding]; other site
693979006054	Walker B motif; other site
693979006055	DNA binding loops [nucleotide binding]
693979006056	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979006057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979006058	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979006059	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
693979006060	Active site serine [active]
693979006061	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
693979006062	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
693979006063	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
693979006064	putative oligopeptide transporter, OPT family; Region: TIGR00733
693979006065	OPT oligopeptide transporter protein; Region: OPT; pfam03169
693979006066	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
693979006067	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
693979006068	active site
693979006069	SAM binding site [chemical binding]; other site
693979006070	homodimer interface [polypeptide binding]; other site
693979006071	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979006072	Predicted membrane protein [Function unknown]; Region: COG3059
693979006073	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
693979006074	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
693979006075	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979006076	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693979006077	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
693979006078	putative ligand binding site [chemical binding]; other site
693979006079	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
693979006080	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
693979006081	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
693979006082	ABC-ATPase subunit  interface; other site
693979006083	dimer interface [polypeptide binding]; other site
693979006084	putative PBP binding regions; other site
693979006085	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
693979006086	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
693979006087	Walker A/P-loop; other site
693979006088	ATP binding site [chemical binding]; other site
693979006089	Q-loop/lid; other site
693979006090	ABC transporter signature motif; other site
693979006091	Walker B; other site
693979006092	D-loop; other site
693979006093	H-loop/switch region; other site
693979006094	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
693979006095	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979006096	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
693979006097	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
693979006098	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
693979006099	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
693979006100	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
693979006101	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
693979006102	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
693979006103	active site
693979006104	SAM binding site [chemical binding]; other site
693979006105	homodimer interface [polypeptide binding]; other site
693979006106	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
693979006107	active site
693979006108	putative homodimer interface [polypeptide binding]; other site
693979006109	SAM binding site [chemical binding]; other site
693979006110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979006111	S-adenosylmethionine binding site [chemical binding]; other site
693979006112	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
693979006113	active site
693979006114	SAM binding site [chemical binding]; other site
693979006115	homodimer interface [polypeptide binding]; other site
693979006116	Precorrin-8X methylmutase; Region: CbiC; pfam02570
693979006117	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
693979006118	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
693979006119	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
693979006120	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979006121	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
693979006122	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
693979006123	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
693979006124	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
693979006125	active site
693979006126	C-terminal domain interface [polypeptide binding]; other site
693979006127	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
693979006128	active site
693979006129	N-terminal domain interface [polypeptide binding]; other site
693979006130	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979006131	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
693979006132	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979006133	N-terminal plug; other site
693979006134	ligand-binding site [chemical binding]; other site
693979006135	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693979006136	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979006137	N-terminal plug; other site
693979006138	ligand-binding site [chemical binding]; other site
693979006139	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
693979006140	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
693979006141	active site
693979006142	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
693979006143	active site
693979006144	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
693979006145	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979006146	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979006147	ligand-binding site [chemical binding]; other site
693979006148	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
693979006149	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
693979006150	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
693979006151	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
693979006152	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693979006153	carboxyltransferase (CT) interaction site; other site
693979006154	biotinylation site [posttranslational modification]; other site
693979006155	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
693979006156	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
693979006157	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
693979006158	putative transporter; Validated; Region: PRK03818
693979006159	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
693979006160	TrkA-C domain; Region: TrkA_C; pfam02080
693979006161	TrkA-C domain; Region: TrkA_C; pfam02080
693979006162	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
693979006163	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
693979006164	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
693979006165	Substrate binding site; other site
693979006166	metal-binding site
693979006167	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
693979006168	Phosphotransferase enzyme family; Region: APH; pfam01636
693979006169	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
693979006170	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
693979006171	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
693979006172	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
693979006173	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
693979006174	catalytic triad [active]
693979006175	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979006176	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
693979006177	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979006178	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
693979006179	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979006180	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
693979006181	Probable Catalytic site; other site
693979006182	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979006183	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979006184	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979006185	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
693979006186	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
693979006187	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
693979006188	NAD(P) binding site [chemical binding]; other site
693979006189	homodimer interface [polypeptide binding]; other site
693979006190	substrate binding site [chemical binding]; other site
693979006191	active site
693979006192	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
693979006193	PIN domain; Region: PIN_3; pfam13470
693979006194	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
693979006195	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
693979006196	putative NAD(P) binding site [chemical binding]; other site
693979006197	active site
693979006198	putative substrate binding site [chemical binding]; other site
693979006199	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
693979006200	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
693979006201	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
693979006202	active site
693979006203	homodimer interface [polypeptide binding]; other site
693979006204	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979006205	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
693979006206	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979006207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979006208	NAD(P) binding site [chemical binding]; other site
693979006209	active site
693979006210	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
693979006211	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
693979006212	Mg++ binding site [ion binding]; other site
693979006213	putative catalytic motif [active]
693979006214	putative substrate binding site [chemical binding]; other site
693979006215	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
693979006216	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
693979006217	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
693979006218	active site
693979006219	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979006220	cobyric acid synthase; Provisional; Region: PRK00784
693979006221	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
693979006222	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
693979006223	catalytic triad [active]
693979006224	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
693979006225	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979006226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979006227	homodimer interface [polypeptide binding]; other site
693979006228	catalytic residue [active]
693979006229	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
693979006230	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979006231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979006233	dimer interface [polypeptide binding]; other site
693979006234	phosphorylation site [posttranslational modification]
693979006235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006236	ATP binding site [chemical binding]; other site
693979006237	Mg2+ binding site [ion binding]; other site
693979006238	G-X-G motif; other site
693979006239	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979006241	dimer interface [polypeptide binding]; other site
693979006242	phosphorylation site [posttranslational modification]
693979006243	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
693979006244	catalytic core [active]
693979006245	cobalamin synthase; Reviewed; Region: cobS; PRK00235
693979006246	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
693979006247	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
693979006248	active site pocket [active]
693979006249	putative dimer interface [polypeptide binding]; other site
693979006250	putative cataytic base [active]
693979006251	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
693979006252	homotrimer interface [polypeptide binding]; other site
693979006253	Walker A motif; other site
693979006254	GTP binding site [chemical binding]; other site
693979006255	Walker B motif; other site
693979006256	prolyl-tRNA synthetase; Provisional; Region: PRK08661
693979006257	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
693979006258	dimer interface [polypeptide binding]; other site
693979006259	motif 1; other site
693979006260	active site
693979006261	motif 2; other site
693979006262	motif 3; other site
693979006263	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
693979006264	anticodon binding site; other site
693979006265	zinc-binding site [ion binding]; other site
693979006266	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
693979006267	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979006268	putative active site [active]
693979006269	putative metal binding site [ion binding]; other site
693979006270	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
693979006271	polyphosphate kinase; Provisional; Region: PRK05443
693979006272	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
693979006273	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
693979006274	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
693979006275	domain interface [polypeptide binding]; other site
693979006276	active site
693979006277	catalytic site [active]
693979006278	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
693979006279	domain interface [polypeptide binding]; other site
693979006280	active site
693979006281	catalytic site [active]
693979006282	exopolyphosphatase; Region: exo_poly_only; TIGR03706
693979006283	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
693979006284	Family of unknown function (DUF490); Region: DUF490; pfam04357
693979006285	UGMP family protein; Validated; Region: PRK09604
693979006286	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
693979006287	Competence-damaged protein; Region: CinA; pfam02464
693979006288	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
693979006289	ribosomal protein L33; Region: rpl33; CHL00104
693979006290	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
693979006291	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
693979006292	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
693979006293	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
693979006294	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
693979006295	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
693979006296	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979006297	FeS/SAM binding site; other site
693979006298	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
693979006299	IHF dimer interface [polypeptide binding]; other site
693979006300	IHF - DNA interface [nucleotide binding]; other site
693979006301	MoxR-like ATPases [General function prediction only]; Region: COG0714
693979006302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979006303	Walker A motif; other site
693979006304	ATP binding site [chemical binding]; other site
693979006305	Walker B motif; other site
693979006306	arginine finger; other site
693979006307	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
693979006308	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
693979006309	metal ion-dependent adhesion site (MIDAS); other site
693979006310	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
693979006311	metal ion-dependent adhesion site (MIDAS); other site
693979006312	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
693979006313	metal ion-dependent adhesion site (MIDAS); other site
693979006314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979006315	binding surface
693979006316	TPR motif; other site
693979006317	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979006318	Oxygen tolerance; Region: BatD; pfam13584
693979006319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979006320	binding surface
693979006321	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979006322	TPR motif; other site
693979006323	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
693979006324	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
693979006325	Ligand Binding Site [chemical binding]; other site
693979006326	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
693979006327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979006328	TPR motif; other site
693979006329	binding surface
693979006330	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979006331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979006332	TPR motif; other site
693979006333	binding surface
693979006334	DNA gyrase subunit A; Validated; Region: PRK05560
693979006335	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
693979006336	CAP-like domain; other site
693979006337	active site
693979006338	primary dimer interface [polypeptide binding]; other site
693979006339	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006340	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006341	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006342	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006343	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006344	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
693979006345	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
693979006346	Clp amino terminal domain; Region: Clp_N; pfam02861
693979006347	Clp amino terminal domain; Region: Clp_N; pfam02861
693979006348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979006349	Walker A motif; other site
693979006350	ATP binding site [chemical binding]; other site
693979006351	Walker B motif; other site
693979006352	arginine finger; other site
693979006353	UvrB/uvrC motif; Region: UVR; pfam02151
693979006354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979006355	Walker A motif; other site
693979006356	ATP binding site [chemical binding]; other site
693979006357	Walker B motif; other site
693979006358	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
693979006359	heat shock protein 90; Provisional; Region: PRK05218
693979006360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006361	ATP binding site [chemical binding]; other site
693979006362	Mg2+ binding site [ion binding]; other site
693979006363	G-X-G motif; other site
693979006364	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
693979006365	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
693979006366	active site
693979006367	nucleophile elbow; other site
693979006368	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
693979006369	dihydrodipicolinate synthase; Region: dapA; TIGR00674
693979006370	dimer interface [polypeptide binding]; other site
693979006371	active site
693979006372	catalytic residue [active]
693979006373	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
693979006374	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
693979006375	nucleotide binding pocket [chemical binding]; other site
693979006376	K-X-D-G motif; other site
693979006377	catalytic site [active]
693979006378	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
693979006379	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
693979006380	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
693979006381	Dimer interface [polypeptide binding]; other site
693979006382	BRCT sequence motif; other site
693979006383	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
693979006384	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
693979006385	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
693979006386	heterodimer interface [polypeptide binding]; other site
693979006387	active site
693979006388	FMN binding site [chemical binding]; other site
693979006389	homodimer interface [polypeptide binding]; other site
693979006390	substrate binding site [chemical binding]; other site
693979006391	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
693979006392	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
693979006393	FAD binding pocket [chemical binding]; other site
693979006394	FAD binding motif [chemical binding]; other site
693979006395	phosphate binding motif [ion binding]; other site
693979006396	beta-alpha-beta structure motif; other site
693979006397	NAD binding pocket [chemical binding]; other site
693979006398	Iron coordination center [ion binding]; other site
693979006399	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979006400	non-specific DNA binding site [nucleotide binding]; other site
693979006401	salt bridge; other site
693979006402	sequence-specific DNA binding site [nucleotide binding]; other site
693979006403	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
693979006404	DNA polymerase III, delta subunit; Region: holA; TIGR01128
693979006405	AMP nucleosidase; Provisional; Region: PRK07115
693979006406	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
693979006407	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979006408	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
693979006409	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
693979006410	Putative zinc ribbon domain; Region: DUF164; pfam02591
693979006411	Uncharacterized conserved protein [Function unknown]; Region: COG0327
693979006412	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
693979006413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
693979006414	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
693979006415	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
693979006416	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979006417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979006418	Walker A/P-loop; other site
693979006419	ATP binding site [chemical binding]; other site
693979006420	Q-loop/lid; other site
693979006421	ABC transporter signature motif; other site
693979006422	Walker B; other site
693979006423	D-loop; other site
693979006424	H-loop/switch region; other site
693979006425	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
693979006426	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
693979006427	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
693979006428	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
693979006429	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
693979006430	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
693979006431	putative active site; other site
693979006432	catalytic triad [active]
693979006433	putative dimer interface [polypeptide binding]; other site
693979006434	Predicted membrane protein [Function unknown]; Region: COG2246
693979006435	GtrA-like protein; Region: GtrA; pfam04138
693979006436	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
693979006437	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
693979006438	dimer interface [polypeptide binding]; other site
693979006439	anticodon binding site; other site
693979006440	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
693979006441	homodimer interface [polypeptide binding]; other site
693979006442	motif 1; other site
693979006443	active site
693979006444	motif 2; other site
693979006445	GAD domain; Region: GAD; pfam02938
693979006446	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
693979006447	motif 3; other site
693979006448	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
693979006449	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
693979006450	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
693979006451	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
693979006452	substrate-cofactor binding pocket; other site
693979006453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979006454	catalytic residue [active]
693979006455	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979006456	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
693979006457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979006458	S-adenosylmethionine binding site [chemical binding]; other site
693979006459	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
693979006460	Found in ATP-dependent protease La (LON); Region: LON; smart00464
693979006461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979006462	Walker A motif; other site
693979006463	ATP binding site [chemical binding]; other site
693979006464	Walker B motif; other site
693979006465	arginine finger; other site
693979006466	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
693979006467	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
693979006468	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
693979006469	Predicted permeases [General function prediction only]; Region: COG0795
693979006470	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
693979006471	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979006472	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979006473	catalytic residues [active]
693979006474	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
693979006475	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
693979006476	phosphoserine phosphatase SerB; Region: serB; TIGR00338
693979006477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979006478	motif II; other site
693979006479	helicase 45; Provisional; Region: PTZ00424
693979006480	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693979006481	ATP binding site [chemical binding]; other site
693979006482	Mg++ binding site [ion binding]; other site
693979006483	motif III; other site
693979006484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979006485	nucleotide binding region [chemical binding]; other site
693979006486	ATP-binding site [chemical binding]; other site
693979006487	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
693979006488	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693979006489	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
693979006490	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
693979006491	Sporulation related domain; Region: SPOR; pfam05036
693979006492	FHA domain; Region: FHA; pfam00498
693979006493	phosphopeptide binding site; other site
693979006494	glucuronate isomerase; Reviewed; Region: PRK02925
693979006495	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
693979006496	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
693979006497	Domain of unknown function (DUF1893); Region: TM1506; pfam08973
693979006498	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
693979006499	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
693979006500	Sulfatase; Region: Sulfatase; pfam00884
693979006501	Surface antigen; Region: Bac_surface_Ag; pfam01103
693979006502	DoxX; Region: DoxX; pfam07681
693979006503	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
693979006504	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
693979006505	Surface antigen; Region: Bac_surface_Ag; pfam01103
693979006506	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
693979006507	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
693979006508	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
693979006509	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
693979006510	lipoprotein signal peptidase; Provisional; Region: PRK14788
693979006511	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
693979006512	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
693979006513	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
693979006514	HIGH motif; other site
693979006515	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979006516	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
693979006517	active site
693979006518	KMSKS motif; other site
693979006519	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
693979006520	tRNA binding surface [nucleotide binding]; other site
693979006521	anticodon binding site; other site
693979006522	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979006523	Coenzyme A binding pocket [chemical binding]; other site
693979006524	Predicted amidohydrolase [General function prediction only]; Region: COG0388
693979006525	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
693979006526	putative active site [active]
693979006527	catalytic triad [active]
693979006528	putative dimer interface [polypeptide binding]; other site
693979006529	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364
693979006530	ATP cone domain; Region: ATP-cone; pfam03477
693979006531	Class I ribonucleotide reductase; Region: RNR_I; cd01679
693979006532	active site
693979006533	dimer interface [polypeptide binding]; other site
693979006534	catalytic residues [active]
693979006535	effector binding site; other site
693979006536	R2 peptide binding site; other site
693979006537	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
693979006538	dimer interface [polypeptide binding]; other site
693979006539	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
693979006540	putative radical transfer pathway; other site
693979006541	diiron center [ion binding]; other site
693979006542	tyrosyl radical; other site
693979006543	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
693979006544	Sulfatase; Region: Sulfatase; cl17466
693979006545	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
693979006546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979006547	putative substrate translocation pore; other site
693979006548	xylose isomerase; Provisional; Region: PRK05474
693979006549	xylose isomerase; Region: xylose_isom_A; TIGR02630
693979006550	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
693979006551	D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810
693979006552	putative N- and C-terminal domain interface [polypeptide binding]; other site
693979006553	putative active site [active]
693979006554	putative MgATP binding site [chemical binding]; other site
693979006555	catalytic site [active]
693979006556	metal binding site [ion binding]; metal-binding site
693979006557	putative xylulose binding site [chemical binding]; other site
693979006558	putative homodimer interface [polypeptide binding]; other site
693979006559	NUDIX domain; Region: NUDIX; pfam00293
693979006560	nudix motif; other site
693979006561	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
693979006562	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
693979006563	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
693979006564	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
693979006565	thiS-thiF/thiG interaction site; other site
693979006566	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
693979006567	active site
693979006568	thiamine phosphate binding site [chemical binding]; other site
693979006569	pyrophosphate binding site [ion binding]; other site
693979006570	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
693979006571	ThiS interaction site; other site
693979006572	putative active site [active]
693979006573	tetramer interface [polypeptide binding]; other site
693979006574	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
693979006575	ThiC-associated domain; Region: ThiC-associated; pfam13667
693979006576	ThiC family; Region: ThiC; pfam01964
693979006577	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
693979006578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979006579	FeS/SAM binding site; other site
693979006580	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
693979006581	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
693979006582	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
693979006583	ATP binding site [chemical binding]; other site
693979006584	substrate interface [chemical binding]; other site
693979006585	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
693979006586	thiamine phosphate binding site [chemical binding]; other site
693979006587	active site
693979006588	pyrophosphate binding site [ion binding]; other site
693979006589	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
693979006590	dimer interface [polypeptide binding]; other site
693979006591	substrate binding site [chemical binding]; other site
693979006592	ATP binding site [chemical binding]; other site
693979006593	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
693979006594	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
693979006595	active site
693979006596	nucleophile elbow; other site
693979006597	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
693979006598	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
693979006599	active site
693979006600	catalytic site [active]
693979006601	TIGR02453 family protein; Region: TIGR02453
693979006602	Domain of unknown function (DUF386); Region: DUF386; cl01047
693979006603	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
693979006604	N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854
693979006605	Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321
693979006606	active site
693979006607	catalytic site [active]
693979006608	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
693979006609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979006610	binding surface
693979006611	TPR motif; other site
693979006612	probable metal-binding protein; Region: matur_matur; TIGR03853
693979006613	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
693979006614	Urea transporter; Region: UT; pfam03253
693979006615	NlpE N-terminal domain; Region: NlpE; pfam04170
693979006616	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979006617	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
693979006618	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979006619	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979006620	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979006621	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979006622	CHC2 zinc finger; Region: zf-CHC2; cl17510
693979006623	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
693979006624	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
693979006625	oligomer interface [polypeptide binding]; other site
693979006626	active site residues [active]
693979006627	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
693979006628	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
693979006629	MPN+ (JAMM) motif; other site
693979006630	Zinc-binding site [ion binding]; other site
693979006631	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
693979006632	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
693979006633	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
693979006634	MAC/Perforin domain; Region: MACPF; cl02616
693979006635	MAC/Perforin domain; Region: MACPF; cl02616
693979006636	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
693979006637	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
693979006638	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979006639	active site
693979006640	DNA binding site [nucleotide binding]
693979006641	Int/Topo IB signature motif; other site
693979006642	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
693979006643	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
693979006644	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979006645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
693979006646	active site
693979006647	phosphorylation site [posttranslational modification]
693979006648	intermolecular recognition site; other site
693979006649	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006651	ATP binding site [chemical binding]; other site
693979006652	Mg2+ binding site [ion binding]; other site
693979006653	G-X-G motif; other site
693979006654	GAF domain; Region: GAF_3; pfam13492
693979006655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006657	ATP binding site [chemical binding]; other site
693979006658	Mg2+ binding site [ion binding]; other site
693979006659	G-X-G motif; other site
693979006660	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
693979006661	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
693979006662	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979006663	active site
693979006664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
693979006665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
693979006666	MORN repeat; Region: MORN; cl14787
693979006667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
693979006668	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979006669	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979006670	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979006671	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
693979006672	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
693979006673	Ligand binding site; other site
693979006674	oligomer interface; other site
693979006675	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
693979006676	catalytic center binding site [active]
693979006677	ATP binding site [chemical binding]; other site
693979006678	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
693979006679	Transglycosylase; Region: Transgly; pfam00912
693979006680	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
693979006681	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
693979006682	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693979006683	inhibitor-cofactor binding pocket; inhibition site
693979006684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979006685	catalytic residue [active]
693979006686	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
693979006687	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
693979006688	putative trimer interface [polypeptide binding]; other site
693979006689	putative CoA binding site [chemical binding]; other site
693979006690	Bacterial sugar transferase; Region: Bac_transf; pfam02397
693979006691	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979006692	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
693979006693	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
693979006694	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
693979006695	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
693979006696	putative NAD(P) binding site [chemical binding]; other site
693979006697	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
693979006698	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
693979006699	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
693979006700	putative active site [active]
693979006701	putative metal binding site [ion binding]; other site
693979006702	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
693979006703	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
693979006704	Probable Catalytic site; other site
693979006705	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979006706	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
693979006707	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
693979006708	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
693979006709	active site
693979006710	homodimer interface [polypeptide binding]; other site
693979006711	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
693979006712	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
693979006713	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
693979006714	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979006715	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979006716	VirE N-terminal domain; Region: VirE_N; pfam08800
693979006717	Virulence-associated protein E; Region: VirE; pfam05272
693979006718	Domain of unknown function (DUF4248); Region: DUF4248; pfam14053
693979006719	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979006720	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
693979006721	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979006722	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979006723	Secretin and TonB N terminus short domain; Region: STN; pfam07660
693979006724	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979006725	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979006726	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979006727	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
693979006728	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979006729	FecR protein; Region: FecR; pfam04773
693979006730	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979006731	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979006732	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979006733	DNA binding residues [nucleotide binding]
693979006734	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
693979006735	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
693979006736	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
693979006737	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
693979006738	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
693979006739	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
693979006740	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
693979006741	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979006742	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
693979006743	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
693979006744	dimer interface [polypeptide binding]; other site
693979006745	active site
693979006746	glycine-pyridoxal phosphate binding site [chemical binding]; other site
693979006747	folate binding site [chemical binding]; other site
693979006748	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
693979006749	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
693979006750	Potassium binding sites [ion binding]; other site
693979006751	Cesium cation binding sites [ion binding]; other site
693979006752	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979006753	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979006754	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979006755	catalytic residues [active]
693979006756	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979006757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006758	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979006759	dimer interface [polypeptide binding]; other site
693979006760	phosphorylation site [posttranslational modification]
693979006761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006762	ATP binding site [chemical binding]; other site
693979006763	Mg2+ binding site [ion binding]; other site
693979006764	G-X-G motif; other site
693979006765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693979006766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979006767	active site
693979006768	phosphorylation site [posttranslational modification]
693979006769	intermolecular recognition site; other site
693979006770	dimerization interface [polypeptide binding]; other site
693979006771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693979006772	DNA binding site [nucleotide binding]
693979006773	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
693979006774	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
693979006775	NADP binding site [chemical binding]; other site
693979006776	active site
693979006777	putative substrate binding site [chemical binding]; other site
693979006778	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
693979006779	core domain interface [polypeptide binding]; other site
693979006780	delta subunit interface [polypeptide binding]; other site
693979006781	epsilon subunit interface [polypeptide binding]; other site
693979006782	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
693979006783	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
693979006784	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
693979006785	beta subunit interaction interface [polypeptide binding]; other site
693979006786	Walker A motif; other site
693979006787	ATP binding site [chemical binding]; other site
693979006788	Walker B motif; other site
693979006789	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
693979006790	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
693979006791	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
693979006792	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
693979006793	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
693979006794	ATP synthase A chain; Region: ATP-synt_A; cl00413
693979006795	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
693979006796	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
693979006797	gamma subunit interface [polypeptide binding]; other site
693979006798	LBP interface [polypeptide binding]; other site
693979006799	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
693979006800	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
693979006801	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
693979006802	alpha subunit interaction interface [polypeptide binding]; other site
693979006803	Walker A motif; other site
693979006804	ATP binding site [chemical binding]; other site
693979006805	Walker B motif; other site
693979006806	inhibitor binding site; inhibition site
693979006807	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
693979006808	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979006809	UDP-glucose 4-epimerase; Region: PLN02240
693979006810	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
693979006811	NAD binding site [chemical binding]; other site
693979006812	homodimer interface [polypeptide binding]; other site
693979006813	active site
693979006814	substrate binding site [chemical binding]; other site
693979006815	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
693979006816	electron transport complex RsxE subunit; Provisional; Region: PRK12405
693979006817	FMN-binding domain; Region: FMN_bind; cl01081
693979006818	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
693979006819	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
693979006820	SLBB domain; Region: SLBB; pfam10531
693979006821	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979006822	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
693979006823	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
693979006824	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
693979006825	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
693979006826	Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034
693979006827	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
693979006828	CTP synthetase; Validated; Region: pyrG; PRK05380
693979006829	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
693979006830	Catalytic site [active]
693979006831	active site
693979006832	UTP binding site [chemical binding]; other site
693979006833	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
693979006834	active site
693979006835	putative oxyanion hole; other site
693979006836	catalytic triad [active]
693979006837	membrane protein insertase; Provisional; Region: PRK01318
693979006838	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
693979006839	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979006840	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
693979006841	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
693979006842	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
693979006843	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
693979006844	Part of AAA domain; Region: AAA_19; pfam13245
693979006845	putative recombination protein RecB; Provisional; Region: PRK13909
693979006846	Family description; Region: UvrD_C_2; pfam13538
693979006847	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
693979006848	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
693979006849	Response regulator receiver domain; Region: Response_reg; pfam00072
693979006850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979006851	active site
693979006852	phosphorylation site [posttranslational modification]
693979006853	intermolecular recognition site; other site
693979006854	dimerization interface [polypeptide binding]; other site
693979006855	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979006857	dimer interface [polypeptide binding]; other site
693979006858	phosphorylation site [posttranslational modification]
693979006859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006860	ATP binding site [chemical binding]; other site
693979006861	Mg2+ binding site [ion binding]; other site
693979006862	G-X-G motif; other site
693979006863	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979006864	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
693979006865	NAD binding site [chemical binding]; other site
693979006866	putative substrate binding site 2 [chemical binding]; other site
693979006867	putative substrate binding site 1 [chemical binding]; other site
693979006868	active site
693979006869	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
693979006870	ParB-like nuclease domain; Region: ParBc; pfam02195
693979006871	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
693979006872	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
693979006873	Active Sites [active]
693979006874	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
693979006875	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693979006876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979006877	putative substrate translocation pore; other site
693979006878	LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540
693979006879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979006880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979006881	homodimer interface [polypeptide binding]; other site
693979006882	catalytic residue [active]
693979006883	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
693979006884	ParB-like nuclease domain; Region: ParBc; cl02129
693979006885	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979006886	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979006887	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979006888	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979006889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979006890	Homeodomain-like domain; Region: HTH_23; pfam13384
693979006891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
693979006892	Integrase core domain; Region: rve; pfam00665
693979006893	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
693979006894	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
693979006895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979006896	Walker A motif; other site
693979006897	ATP binding site [chemical binding]; other site
693979006898	Walker B motif; other site
693979006899	arginine finger; other site
693979006900	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979006901	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979006902	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979006903	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979006904	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
693979006905	ligand binding site [chemical binding]; other site
693979006906	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
693979006907	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979006908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979006909	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979006910	active site
693979006911	DNA binding site [nucleotide binding]
693979006912	Int/Topo IB signature motif; other site
693979006913	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
693979006914	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979006915	Coenzyme A binding pocket [chemical binding]; other site
693979006916	recombination protein RecR; Reviewed; Region: recR; PRK00076
693979006917	RecR protein; Region: RecR; pfam02132
693979006918	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
693979006919	putative active site [active]
693979006920	putative metal-binding site [ion binding]; other site
693979006921	tetramer interface [polypeptide binding]; other site
693979006922	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
693979006923	G1 box; other site
693979006924	GTP/Mg2+ binding site [chemical binding]; other site
693979006925	Switch I region; other site
693979006926	G2 box; other site
693979006927	G3 box; other site
693979006928	Switch II region; other site
693979006929	G4 box; other site
693979006930	G5 box; other site
693979006931	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
693979006932	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
693979006933	dimer interface [polypeptide binding]; other site
693979006934	active site
693979006935	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
693979006936	catalytic residues [active]
693979006937	substrate binding site [chemical binding]; other site
693979006938	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
693979006939	Part of AAA domain; Region: AAA_19; pfam13245
693979006940	Family description; Region: UvrD_C_2; pfam13538
693979006941	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
693979006942	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
693979006943	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
693979006944	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
693979006945	thiamine phosphate binding site [chemical binding]; other site
693979006946	active site
693979006947	pyrophosphate binding site [ion binding]; other site
693979006948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979006949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979006950	dimer interface [polypeptide binding]; other site
693979006951	phosphorylation site [posttranslational modification]
693979006952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979006953	ATP binding site [chemical binding]; other site
693979006954	Mg2+ binding site [ion binding]; other site
693979006955	G-X-G motif; other site
693979006956	pyruvate phosphate dikinase; Provisional; Region: PRK09279
693979006957	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
693979006958	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
693979006959	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
693979006960	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
693979006961	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
693979006962	TRAM domain; Region: TRAM; cl01282
693979006963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979006964	S-adenosylmethionine binding site [chemical binding]; other site
693979006965	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
693979006966	RNA binding surface [nucleotide binding]; other site
693979006967	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
693979006968	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
693979006969	active site
693979006970	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
693979006971	HsdM N-terminal domain; Region: HsdM_N; pfam12161
693979006972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979006973	S-adenosylmethionine binding site [chemical binding]; other site
693979006974	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
693979006975	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
693979006976	AAA domain; Region: AAA_13; pfam13166
693979006977	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
693979006978	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
693979006979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979006980	ATP binding site [chemical binding]; other site
693979006981	putative Mg++ binding site [ion binding]; other site
693979006982	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
693979006983	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
693979006984	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
693979006985	DNA binding site [nucleotide binding]
693979006986	active site
693979006987	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979006988	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979006989	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
693979006990	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
693979006991	DNA binding site [nucleotide binding]
693979006992	active site
693979006993	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979006994	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979006995	exonuclease subunit SbcD; Provisional; Region: PRK10966
693979006996	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
693979006997	active site
693979006998	metal binding site [ion binding]; metal-binding site
693979006999	DNA binding site [nucleotide binding]
693979007000	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
693979007001	exonuclease SbcC; Region: sbcc; TIGR00618
693979007002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979007003	Walker A/P-loop; other site
693979007004	ATP binding site [chemical binding]; other site
693979007005	Q-loop/lid; other site
693979007006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979007007	Q-loop/lid; other site
693979007008	ABC transporter signature motif; other site
693979007009	Walker B; other site
693979007010	D-loop; other site
693979007011	H-loop/switch region; other site
693979007012	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
693979007013	active site
693979007014	RmuC family; Region: RmuC; pfam02646
693979007015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
693979007016	active site
693979007017	xanthine permease; Region: pbuX; TIGR03173
693979007018	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
693979007019	GTP-binding protein LepA; Provisional; Region: PRK05433
693979007020	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
693979007021	G1 box; other site
693979007022	putative GEF interaction site [polypeptide binding]; other site
693979007023	GTP/Mg2+ binding site [chemical binding]; other site
693979007024	Switch I region; other site
693979007025	G2 box; other site
693979007026	G3 box; other site
693979007027	Switch II region; other site
693979007028	G4 box; other site
693979007029	G5 box; other site
693979007030	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
693979007031	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
693979007032	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
693979007033	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
693979007034	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
693979007035	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
693979007036	putative active site [active]
693979007037	putative catalytic site [active]
693979007038	putative DNA binding site [nucleotide binding]; other site
693979007039	putative phosphate binding site [ion binding]; other site
693979007040	metal binding site A [ion binding]; metal-binding site
693979007041	putative AP binding site [nucleotide binding]; other site
693979007042	putative metal binding site B [ion binding]; other site
693979007043	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
693979007044	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
693979007045	TSCPD domain; Region: TSCPD; cl14834
693979007046	hypothetical protein; Provisional; Region: PRK12378
693979007047	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
693979007048	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
693979007049	putative tRNA-binding site [nucleotide binding]; other site
693979007050	B3/4 domain; Region: B3_4; pfam03483
693979007051	tRNA synthetase B5 domain; Region: B5; smart00874
693979007052	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
693979007053	dimer interface [polypeptide binding]; other site
693979007054	motif 1; other site
693979007055	motif 3; other site
693979007056	motif 2; other site
693979007057	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
693979007058	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
693979007059	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979007060	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
693979007061	active site
693979007062	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
693979007063	B12 binding domain; Region: B12-binding; pfam02310
693979007064	B12 binding site [chemical binding]; other site
693979007065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979007066	FeS/SAM binding site; other site
693979007067	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
693979007068	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
693979007069	Probable Catalytic site; other site
693979007070	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979007071	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
693979007072	active site
693979007073	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
693979007074	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
693979007075	trimer interface [polypeptide binding]; other site
693979007076	active site
693979007077	substrate binding site [chemical binding]; other site
693979007078	CoA binding site [chemical binding]; other site
693979007079	LicD family; Region: LicD; pfam04991
693979007080	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
693979007081	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
693979007082	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
693979007083	putative active site [active]
693979007084	putative metal binding site [ion binding]; other site
693979007085	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
693979007086	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
693979007087	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
693979007088	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
693979007089	active site
693979007090	metal-binding site
693979007091	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
693979007092	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979007093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979007094	homodimer interface [polypeptide binding]; other site
693979007095	catalytic residue [active]
693979007096	VirE N-terminal domain; Region: VirE_N; pfam08800
693979007097	Virulence-associated protein E; Region: VirE; pfam05272
693979007098	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
693979007099	Domain of unknown function (DUF4248); Region: DUF4248; pfam14053
693979007100	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979007101	Bacterial sugar transferase; Region: Bac_transf; pfam02397
693979007102	UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603
693979007103	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979007104	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
693979007105	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
693979007106	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
693979007107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979007108	S-adenosylmethionine binding site [chemical binding]; other site
693979007109	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
693979007110	glycine dehydrogenase; Provisional; Region: PRK05367
693979007111	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
693979007112	tetramer interface [polypeptide binding]; other site
693979007113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979007114	catalytic residue [active]
693979007115	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
693979007116	tetramer interface [polypeptide binding]; other site
693979007117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979007118	catalytic residue [active]
693979007119	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
693979007120	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
693979007121	HpaII restriction endonuclease; Region: RE_HpaII; pfam09561
693979007122	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
693979007123	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
693979007124	Uncharacterized conserved protein [Function unknown]; Region: COG4198
693979007125	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
693979007126	putative ligand binding site [chemical binding]; other site
693979007127	putative NAD binding site [chemical binding]; other site
693979007128	putative catalytic site [active]
693979007129	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
693979007130	homodimer interface [polypeptide binding]; other site
693979007131	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
693979007132	substrate-cofactor binding pocket; other site
693979007133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979007134	catalytic residue [active]
693979007135	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
693979007136	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
693979007137	ATP binding site [chemical binding]; other site
693979007138	putative Mg++ binding site [ion binding]; other site
693979007139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979007140	nucleotide binding region [chemical binding]; other site
693979007141	ATP-binding site [chemical binding]; other site
693979007142	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
693979007143	RNA binding site [nucleotide binding]; other site
693979007144	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
693979007145	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
693979007146	catalytic loop [active]
693979007147	iron binding site [ion binding]; other site
693979007148	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
693979007149	FAD binding pocket [chemical binding]; other site
693979007150	FAD binding motif [chemical binding]; other site
693979007151	phosphate binding motif [ion binding]; other site
693979007152	beta-alpha-beta structure motif; other site
693979007153	NAD binding pocket [chemical binding]; other site
693979007154	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
693979007155	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
693979007156	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
693979007157	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
693979007158	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
693979007159	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
693979007160	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
693979007161	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
693979007162	trimer interface [polypeptide binding]; other site
693979007163	active site
693979007164	G bulge; other site
693979007165	Surface antigen; Region: Bac_surface_Ag; pfam01103
693979007166	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
693979007167	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
693979007168	DXD motif; other site
693979007169	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
693979007170	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
693979007171	active site
693979007172	catalytic residues [active]
693979007173	metal binding site [ion binding]; metal-binding site
693979007174	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
693979007175	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979007176	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979007177	DNA binding residues [nucleotide binding]
693979007178	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979007179	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
693979007180	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979007181	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
693979007182	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
693979007183	Predicted membrane protein [Function unknown]; Region: COG2860
693979007184	UPF0126 domain; Region: UPF0126; pfam03458
693979007185	UPF0126 domain; Region: UPF0126; pfam03458
693979007186	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
693979007187	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
693979007188	active site
693979007189	homodimer interface [polypeptide binding]; other site
693979007190	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007191	recombination factor protein RarA; Reviewed; Region: PRK13342
693979007192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979007193	Walker A motif; other site
693979007194	ATP binding site [chemical binding]; other site
693979007195	Walker B motif; other site
693979007196	arginine finger; other site
693979007197	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
693979007198	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
693979007199	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
693979007200	putative ligand binding site [chemical binding]; other site
693979007201	putative NAD binding site [chemical binding]; other site
693979007202	catalytic site [active]
693979007203	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
693979007204	putative catalytic site [active]
693979007205	putative metal binding site [ion binding]; other site
693979007206	putative phosphate binding site [ion binding]; other site
693979007207	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
693979007208	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979007209	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007210	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
693979007211	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
693979007212	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
693979007213	active site
693979007214	substrate binding site [chemical binding]; other site
693979007215	Mg2+ binding site [ion binding]; other site
693979007216	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007217	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979007218	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007219	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
693979007220	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007221	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007222	ABC transporter; Region: ABC_tran_2; pfam12848
693979007223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007224	Helix-turn-helix domain; Region: HTH_36; pfam13730
693979007225	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
693979007226	HerA helicase [Replication, recombination, and repair]; Region: COG0433
693979007227	Domain of unknown function DUF87; Region: DUF87; pfam01935
693979007228	HerA helicase [Replication, recombination, and repair]; Region: COG0433
693979007229	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
693979007230	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
693979007231	active site
693979007232	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
693979007233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979007234	S-adenosylmethionine binding site [chemical binding]; other site
693979007235	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
693979007236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979007237	non-specific DNA binding site [nucleotide binding]; other site
693979007238	salt bridge; other site
693979007239	sequence-specific DNA binding site [nucleotide binding]; other site
693979007240	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979007241	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979007242	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979007243	Int/Topo IB signature motif; other site
693979007244	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979007245	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
693979007246	Int/Topo IB signature motif; other site
693979007247	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007248	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693979007249	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007250	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007251	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979007253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979007254	DNA binding residues [nucleotide binding]
693979007255	dimerization interface [polypeptide binding]; other site
693979007256	Virulence protein [General function prediction only]; Region: COG3943
693979007257	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
693979007258	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979007259	Bacterial PH domain; Region: DUF304; pfam03703
693979007260	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
693979007261	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
693979007262	dimer interface [polypeptide binding]; other site
693979007263	Predicted transcriptional regulator [Transcription]; Region: COG5340
693979007264	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
693979007265	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
693979007266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693979007267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
693979007268	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
693979007269	DNA methylase; Region: N6_N4_Mtase; cl17433
693979007270	DNA methylase; Region: N6_N4_Mtase; cl17433
693979007271	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
693979007272	Melibiase; Region: Melibiase; pfam02065
693979007273	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
693979007274	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
693979007275	Walker A/P-loop; other site
693979007276	ATP binding site [chemical binding]; other site
693979007277	Q-loop/lid; other site
693979007278	ABC transporter signature motif; other site
693979007279	Walker B; other site
693979007280	D-loop; other site
693979007281	H-loop/switch region; other site
693979007282	TOBE domain; Region: TOBE_2; pfam08402
693979007283	TOBE domain; Region: TOBE_2; pfam08402
693979007284	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
693979007285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
693979007286	dimer interface [polypeptide binding]; other site
693979007287	conserved gate region; other site
693979007288	putative PBP binding loops; other site
693979007289	ABC-ATPase subunit interface; other site
693979007290	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
693979007291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
693979007292	dimer interface [polypeptide binding]; other site
693979007293	conserved gate region; other site
693979007294	putative PBP binding loops; other site
693979007295	ABC-ATPase subunit interface; other site
693979007296	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
693979007297	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
693979007298	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
693979007299	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
693979007300	active site
693979007301	dimer interface [polypeptide binding]; other site
693979007302	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979007303	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979007304	ligand binding site [chemical binding]; other site
693979007305	Transglycosylase; Region: Transgly; cl17702
693979007306	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
693979007307	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
693979007308	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
693979007309	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
693979007310	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
693979007311	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
693979007312	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
693979007313	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979007314	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979007315	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979007316	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
693979007317	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
693979007318	Walker A/P-loop; other site
693979007319	ATP binding site [chemical binding]; other site
693979007320	Q-loop/lid; other site
693979007321	ABC transporter signature motif; other site
693979007322	Walker B; other site
693979007323	D-loop; other site
693979007324	H-loop/switch region; other site
693979007325	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979007326	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979007327	FtsX-like permease family; Region: FtsX; pfam02687
693979007328	Histidine kinase; Region: His_kinase; pfam06580
693979007329	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
693979007330	ATP binding site [chemical binding]; other site
693979007331	Mg2+ binding site [ion binding]; other site
693979007332	G-X-G motif; other site
693979007333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979007334	Response regulator receiver domain; Region: Response_reg; pfam00072
693979007335	active site
693979007336	phosphorylation site [posttranslational modification]
693979007337	intermolecular recognition site; other site
693979007338	dimerization interface [polypeptide binding]; other site
693979007339	LytTr DNA-binding domain; Region: LytTR; smart00850
693979007340	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
693979007341	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
693979007342	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
693979007343	putative active site [active]
693979007344	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
693979007345	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
693979007346	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
693979007347	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
693979007348	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
693979007349	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
693979007350	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
693979007351	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
693979007352	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979007353	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
693979007354	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
693979007355	NADP-binding site; other site
693979007356	homotetramer interface [polypeptide binding]; other site
693979007357	substrate binding site [chemical binding]; other site
693979007358	homodimer interface [polypeptide binding]; other site
693979007359	active site
693979007360	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
693979007361	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
693979007362	NADP binding site [chemical binding]; other site
693979007363	active site
693979007364	putative substrate binding site [chemical binding]; other site
693979007365	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
693979007366	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979007367	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
693979007368	acyl-activating enzyme (AAE) consensus motif; other site
693979007369	putative AMP binding site [chemical binding]; other site
693979007370	putative active site [active]
693979007371	putative CoA binding site [chemical binding]; other site
693979007372	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
693979007373	putative transporter; Validated; Region: PRK03818
693979007374	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
693979007375	TrkA-C domain; Region: TrkA_C; pfam02080
693979007376	TrkA-C domain; Region: TrkA_C; pfam02080
693979007377	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
693979007378	Phosphate transporter family; Region: PHO4; pfam01384
693979007379	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
693979007380	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
693979007381	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
693979007382	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979007383	Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321
693979007384	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
693979007385	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979007386	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
693979007387	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
693979007388	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979007389	acyl-activating enzyme (AAE) consensus motif; other site
693979007390	AMP binding site [chemical binding]; other site
693979007391	active site
693979007392	CoA binding site [chemical binding]; other site
693979007393	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
693979007394	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
693979007395	active site
693979007396	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693979007397	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
693979007398	substrate binding site [chemical binding]; other site
693979007399	oxyanion hole (OAH) forming residues; other site
693979007400	trimer interface [polypeptide binding]; other site
693979007401	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
693979007402	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
693979007403	dimer interface [polypeptide binding]; other site
693979007404	tetramer interface [polypeptide binding]; other site
693979007405	PYR/PP interface [polypeptide binding]; other site
693979007406	TPP binding site [chemical binding]; other site
693979007407	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
693979007408	TPP-binding site; other site
693979007409	chorismate binding enzyme; Region: Chorismate_bind; cl10555
693979007410	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
693979007411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
693979007412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
693979007413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
693979007414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
693979007415	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
693979007416	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
693979007417	ligand binding site [chemical binding]; other site
693979007418	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979007419	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979007420	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007421	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
693979007422	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979007423	N-terminal plug; other site
693979007424	ligand-binding site [chemical binding]; other site
693979007425	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
693979007426	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
693979007427	active site
693979007428	metal binding site [ion binding]; metal-binding site
693979007429	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
693979007430	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979007431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979007432	dimer interface [polypeptide binding]; other site
693979007433	phosphorylation site [posttranslational modification]
693979007434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979007435	ATP binding site [chemical binding]; other site
693979007436	Mg2+ binding site [ion binding]; other site
693979007437	G-X-G motif; other site
693979007438	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
693979007439	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
693979007440	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
693979007441	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
693979007442	RNA binding site [nucleotide binding]; other site
693979007443	CAAX protease self-immunity; Region: Abi; pfam02517
693979007444	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
693979007445	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
693979007446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979007447	Walker A/P-loop; other site
693979007448	ATP binding site [chemical binding]; other site
693979007449	Q-loop/lid; other site
693979007450	ABC transporter signature motif; other site
693979007451	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007452	Walker B; other site
693979007453	D-loop; other site
693979007454	H-loop/switch region; other site
693979007455	ABC transporter; Region: ABC_tran_2; pfam12848
693979007456	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007457	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979007458	N-terminal plug; other site
693979007459	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
693979007460	ligand-binding site [chemical binding]; other site
693979007461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979007462	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
693979007463	putative substrate translocation pore; other site
693979007464	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
693979007465	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979007466	FeS/SAM binding site; other site
693979007467	HemN C-terminal domain; Region: HemN_C; pfam06969
693979007468	protoporphyrinogen oxidase; Region: PLN02576
693979007469	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
693979007470	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
693979007471	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
693979007472	active site
693979007473	GrpE; Region: GrpE; pfam01025
693979007474	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
693979007475	dimer interface [polypeptide binding]; other site
693979007476	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
693979007477	chaperone protein DnaJ; Provisional; Region: PRK14289
693979007478	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
693979007479	HSP70 interaction site [polypeptide binding]; other site
693979007480	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
693979007481	substrate binding site [polypeptide binding]; other site
693979007482	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
693979007483	Zn binding sites [ion binding]; other site
693979007484	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
693979007485	dimer interface [polypeptide binding]; other site
693979007486	NVEALA protein; Region: NVEALA; pfam14055
693979007487	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979007488	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
693979007489	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
693979007490	active site
693979007491	catalytic triad [active]
693979007492	oxyanion hole [active]
693979007493	Domain of unknown function (DUF303); Region: DUF303; pfam03629
693979007494	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
693979007495	Galactose oxidase, central domain; Region: Kelch_3; cl02701
693979007496	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
693979007497	active site
693979007498	catalytic triad [active]
693979007499	oxyanion hole [active]
693979007500	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979007501	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979007502	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
693979007503	active site
693979007504	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
693979007505	catalytic site [active]
693979007506	BNR repeat-like domain; Region: BNR_2; pfam13088
693979007507	Asp-box motif; other site
693979007508	Abhydrolase family; Region: Abhydrolase_7; pfam12715
693979007509	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979007510	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979007511	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007512	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979007513	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007514	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979007515	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
693979007516	dimerization interface [polypeptide binding]; other site
693979007517	putative active cleft [active]
693979007518	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
693979007519	Class I aldolases; Region: Aldolase_Class_I; cl17187
693979007520	catalytic residue [active]
693979007521	D-galactonate transporter; Region: 2A0114; TIGR00893
693979007522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979007523	putative substrate translocation pore; other site
693979007524	Domain of unknown function (DUF386); Region: DUF386; cl01047
693979007525	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
693979007526	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979007527	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979007528	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979007529	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
693979007530	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979007531	active site
693979007532	Fn3 associated; Region: Fn3_assoc; pfam13287
693979007533	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
693979007534	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
693979007535	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
693979007536	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
693979007537	active site
693979007538	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
693979007539	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
693979007540	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
693979007541	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
693979007542	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
693979007543	putative DNA binding site [nucleotide binding]; other site
693979007544	dimerization interface [polypeptide binding]; other site
693979007545	putative Zn2+ binding site [ion binding]; other site
693979007546	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693979007547	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
693979007548	nucleotide binding site [chemical binding]; other site
693979007549	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
693979007550	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979007551	Chain length determinant protein; Region: Wzz; cl15801
693979007552	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
693979007553	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
693979007554	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
693979007555	SLBB domain; Region: SLBB; pfam10531
693979007556	SLBB domain; Region: SLBB; pfam10531
693979007557	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
693979007558	SLBB domain; Region: SLBB; pfam10531
693979007559	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
693979007560	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
693979007561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979007562	NAD(P) binding site [chemical binding]; other site
693979007563	active site
693979007564	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
693979007565	virion protein; Provisional; Region: V; PHA02564
693979007566	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979007567	non-specific DNA binding site [nucleotide binding]; other site
693979007568	salt bridge; other site
693979007569	sequence-specific DNA binding site [nucleotide binding]; other site
693979007570	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
693979007571	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
693979007572	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
693979007573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979007574	non-specific DNA binding site [nucleotide binding]; other site
693979007575	salt bridge; other site
693979007576	sequence-specific DNA binding site [nucleotide binding]; other site
693979007577	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
693979007578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
693979007579	non-specific DNA binding site [nucleotide binding]; other site
693979007580	salt bridge; other site
693979007581	sequence-specific DNA binding site [nucleotide binding]; other site
693979007582	YceG-like family; Region: YceG; pfam02618
693979007583	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
693979007584	dimerization interface [polypeptide binding]; other site
693979007585	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
693979007586	dimer interface [polypeptide binding]; other site
693979007587	PYR/PP interface [polypeptide binding]; other site
693979007588	TPP binding site [chemical binding]; other site
693979007589	substrate binding site [chemical binding]; other site
693979007590	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
693979007591	TPP-binding site; other site
693979007592	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
693979007593	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
693979007594	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
693979007595	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
693979007596	acyl-activating enzyme (AAE) consensus motif; other site
693979007597	AMP binding site [chemical binding]; other site
693979007598	active site
693979007599	CoA binding site [chemical binding]; other site
693979007600	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
693979007601	23S rRNA binding site [nucleotide binding]; other site
693979007602	L21 binding site [polypeptide binding]; other site
693979007603	L13 binding site [polypeptide binding]; other site
693979007604	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
693979007605	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
693979007606	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
693979007607	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
693979007608	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
693979007609	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
693979007610	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
693979007611	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
693979007612	active site
693979007613	dimer interface [polypeptide binding]; other site
693979007614	motif 1; other site
693979007615	motif 2; other site
693979007616	motif 3; other site
693979007617	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
693979007618	anticodon binding site; other site
693979007619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007620	TPR motif; other site
693979007621	TPR repeat; Region: TPR_11; pfam13414
693979007622	binding surface
693979007623	TPR repeat; Region: TPR_11; pfam13414
693979007624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007625	binding surface
693979007626	TPR repeat; Region: TPR_11; pfam13414
693979007627	TPR motif; other site
693979007628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007629	binding surface
693979007630	TPR repeat; Region: TPR_11; pfam13414
693979007631	TPR motif; other site
693979007632	TPR repeat; Region: TPR_11; pfam13414
693979007633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007634	binding surface
693979007635	TPR motif; other site
693979007636	TPR repeat; Region: TPR_11; pfam13414
693979007637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007638	binding surface
693979007639	TPR motif; other site
693979007640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979007641	TPR repeat; Region: TPR_11; pfam13414
693979007642	binding surface
693979007643	TPR motif; other site
693979007644	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
693979007645	active site
693979007646	catalytic residues [active]
693979007647	metal binding site [ion binding]; metal-binding site
693979007648	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
693979007649	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
693979007650	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979007651	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979007652	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979007653	ligand binding site [chemical binding]; other site
693979007654	Domain of unknown function (DUF3869); Region: DUF3869; pfam12985
693979007655	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
693979007656	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
693979007657	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979007658	active site
693979007659	DNA binding site [nucleotide binding]
693979007660	Int/Topo IB signature motif; other site
693979007661	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
693979007662	Domain of unknown function (DUF3869); Region: DUF3869; pfam12985
693979007663	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979007664	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979007665	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979007666	ligand binding site [chemical binding]; other site
693979007667	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
693979007668	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
693979007669	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
693979007670	CysD dimerization site [polypeptide binding]; other site
693979007671	G1 box; other site
693979007672	putative GEF interaction site [polypeptide binding]; other site
693979007673	GTP/Mg2+ binding site [chemical binding]; other site
693979007674	Switch I region; other site
693979007675	G2 box; other site
693979007676	G3 box; other site
693979007677	Switch II region; other site
693979007678	G4 box; other site
693979007679	G5 box; other site
693979007680	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
693979007681	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
693979007682	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
693979007683	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
693979007684	Active Sites [active]
693979007685	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
693979007686	ligand-binding site [chemical binding]; other site
693979007687	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
693979007688	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
693979007689	transmembrane helices; other site
693979007690	TrkA-C domain; Region: TrkA_C; pfam02080
693979007691	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
693979007692	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
693979007693	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
693979007694	active site
693979007695	Sporulation related domain; Region: SPOR; cl10051
693979007696	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
693979007697	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
693979007698	ATP binding site [chemical binding]; other site
693979007699	Mg++ binding site [ion binding]; other site
693979007700	motif III; other site
693979007701	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979007702	nucleotide binding region [chemical binding]; other site
693979007703	ATP-binding site [chemical binding]; other site
693979007704	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
693979007705	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
693979007706	ligand binding site [chemical binding]; other site
693979007707	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
693979007708	active site
693979007709	catalytic residues [active]
693979007710	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693979007711	L-fucose transporter; Provisional; Region: PRK10133; cl17665
693979007712	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
693979007713	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
693979007714	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
693979007715	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
693979007716	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
693979007717	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
693979007718	TPP-binding site [chemical binding]; other site
693979007719	dimer interface [polypeptide binding]; other site
693979007720	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
693979007721	PYR/PP interface [polypeptide binding]; other site
693979007722	dimer interface [polypeptide binding]; other site
693979007723	TPP binding site [chemical binding]; other site
693979007724	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693979007725	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
693979007726	TPR repeat; Region: TPR_11; pfam13414
693979007727	Tetratricopeptide repeats; Region: TPR; smart00028
693979007728	Ferredoxin [Energy production and conversion]; Region: COG1146
693979007729	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
693979007730	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
693979007731	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
693979007732	dimer interface [polypeptide binding]; other site
693979007733	PYR/PP interface [polypeptide binding]; other site
693979007734	TPP binding site [chemical binding]; other site
693979007735	substrate binding site [chemical binding]; other site
693979007736	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
693979007737	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
693979007738	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
693979007739	TPP-binding site [chemical binding]; other site
693979007740	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
693979007741	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
693979007742	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
693979007743	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
693979007744	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
693979007745	substrate binding pocket [chemical binding]; other site
693979007746	membrane-bound complex binding site; other site
693979007747	hinge residues; other site
693979007748	NAD synthetase; Reviewed; Region: nadE; PRK02628
693979007749	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
693979007750	multimer interface [polypeptide binding]; other site
693979007751	active site
693979007752	catalytic triad [active]
693979007753	protein interface 1 [polypeptide binding]; other site
693979007754	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
693979007755	homodimer interface [polypeptide binding]; other site
693979007756	NAD binding pocket [chemical binding]; other site
693979007757	ATP binding pocket [chemical binding]; other site
693979007758	Mg binding site [ion binding]; other site
693979007759	active-site loop [active]
693979007760	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
693979007761	metal binding site 2 [ion binding]; metal-binding site
693979007762	putative DNA binding helix; other site
693979007763	metal binding site 1 [ion binding]; metal-binding site
693979007764	dimer interface [polypeptide binding]; other site
693979007765	structural Zn2+ binding site [ion binding]; other site
693979007766	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
693979007767	Rubredoxin; Region: Rubredoxin; pfam00301
693979007768	iron binding site [ion binding]; other site
693979007769	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
693979007770	Rubrerythrin [Energy production and conversion]; Region: COG1592
693979007771	diiron binding motif [ion binding]; other site
693979007772	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979007773	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979007774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979007775	DNA binding residues [nucleotide binding]
693979007776	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
693979007777	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
693979007778	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
693979007779	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
693979007780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
693979007781	S-adenosylmethionine binding site [chemical binding]; other site
693979007782	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
693979007783	FtsX-like permease family; Region: FtsX; pfam02687
693979007784	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
693979007785	FtsX-like permease family; Region: FtsX; pfam02687
693979007786	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
693979007787	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
693979007788	active site
693979007789	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
693979007790	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
693979007791	active site
693979007792	ADP/pyrophosphate binding site [chemical binding]; other site
693979007793	dimerization interface [polypeptide binding]; other site
693979007794	allosteric effector site; other site
693979007795	fructose-1,6-bisphosphate binding site; other site
693979007796	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
693979007797	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
693979007798	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
693979007799	putative acyl-acceptor binding pocket; other site
693979007800	C-N hydrolase family amidase; Provisional; Region: PRK10438
693979007801	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
693979007802	putative active site [active]
693979007803	catalytic triad [active]
693979007804	dimer interface [polypeptide binding]; other site
693979007805	multimer interface [polypeptide binding]; other site
693979007806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
693979007807	WYL domain; Region: WYL; pfam13280
693979007808	OmpA family; Region: OmpA; pfam00691
693979007809	ligand binding site [chemical binding]; other site
693979007810	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
693979007811	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
693979007812	active site
693979007813	dimer interface [polypeptide binding]; other site
693979007814	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
693979007815	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
693979007816	active site
693979007817	trimer interface [polypeptide binding]; other site
693979007818	allosteric site; other site
693979007819	active site lid [active]
693979007820	hexamer (dimer of trimers) interface [polypeptide binding]; other site
693979007821	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
693979007822	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
693979007823	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
693979007824	Interdomain contacts; other site
693979007825	Cytokine receptor motif; other site
693979007826	SirA-like protein; Region: SirA; pfam01206
693979007827	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
693979007828	hypothetical protein; Provisional; Region: PRK00955
693979007829	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
693979007830	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979007831	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979007832	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979007833	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
693979007834	active site
693979007835	catalytic tetrad [active]
693979007836	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979007837	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979007838	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
693979007839	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
693979007840	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979007841	ATP binding site [chemical binding]; other site
693979007842	putative Mg++ binding site [ion binding]; other site
693979007843	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979007844	nucleotide binding region [chemical binding]; other site
693979007845	ATP-binding site [chemical binding]; other site
693979007846	TRCF domain; Region: TRCF; pfam03461
693979007847	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
693979007848	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
693979007849	Ligand binding site; other site
693979007850	Putative Catalytic site; other site
693979007851	DXD motif; other site
693979007852	dihydroorotase; Reviewed; Region: PRK09236
693979007853	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
693979007854	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
693979007855	active site
693979007856	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
693979007857	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
693979007858	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979007859	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979007860	DNA binding residues [nucleotide binding]
693979007861	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
693979007862	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
693979007863	putative active site [active]
693979007864	putative metal binding site [ion binding]; other site
693979007865	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
693979007866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
693979007867	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979007868	SusD family; Region: SusD; pfam07980
693979007869	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979007870	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979007871	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979007872	FecR protein; Region: FecR; pfam04773
693979007873	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
693979007874	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
693979007875	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979007876	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979007877	DNA binding residues [nucleotide binding]
693979007878	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
693979007879	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
693979007880	putative acyl-acceptor binding pocket; other site
693979007881	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979007882	anaerobic sulfatase-maturase; Provisional; Region: PRK13745
693979007883	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
693979007884	FeS/SAM binding site; other site
693979007885	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
693979007886	Peptidase S46; Region: Peptidase_S46; pfam10459
693979007887	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
693979007888	Peptidase S46; Region: Peptidase_S46; pfam10459
693979007889	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
693979007890	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693979007891	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979007892	catalytic residues [active]
693979007893	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
693979007894	catalytic residues [active]
693979007895	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
693979007896	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
693979007897	active site
693979007898	dimer interface [polypeptide binding]; other site
693979007899	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
693979007900	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979007901	Walker A/P-loop; other site
693979007902	ATP binding site [chemical binding]; other site
693979007903	Q-loop/lid; other site
693979007904	ABC transporter signature motif; other site
693979007905	Walker B; other site
693979007906	D-loop; other site
693979007907	H-loop/switch region; other site
693979007908	ABC transporter; Region: ABC_tran_2; pfam12848
693979007909	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979007910	Domain of unknown function (DUF3805); Region: DUF3805; pfam12712
693979007911	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
693979007912	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693979007913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979007914	active site
693979007915	phosphorylation site [posttranslational modification]
693979007916	intermolecular recognition site; other site
693979007917	dimerization interface [polypeptide binding]; other site
693979007918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693979007919	DNA binding site [nucleotide binding]
693979007920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979007921	dimer interface [polypeptide binding]; other site
693979007922	phosphorylation site [posttranslational modification]
693979007923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979007924	ATP binding site [chemical binding]; other site
693979007925	Mg2+ binding site [ion binding]; other site
693979007926	G-X-G motif; other site
693979007927	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
693979007928	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
693979007929	gliding motility-associated protein GldE; Region: GldE; TIGR03520
693979007930	Domain of unknown function DUF21; Region: DUF21; pfam01595
693979007931	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
693979007932	Transporter associated domain; Region: CorC_HlyC; smart01091
693979007933	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
693979007934	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
693979007935	dimer interface [polypeptide binding]; other site
693979007936	ssDNA binding site [nucleotide binding]; other site
693979007937	tetramer (dimer of dimers) interface [polypeptide binding]; other site
693979007938	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
693979007939	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
693979007940	minor groove reading motif; other site
693979007941	helix-hairpin-helix signature motif; other site
693979007942	substrate binding pocket [chemical binding]; other site
693979007943	active site
693979007944	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
693979007945	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
693979007946	DNA binding and oxoG recognition site [nucleotide binding]
693979007947	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
693979007948	IHF - DNA interface [nucleotide binding]; other site
693979007949	IHF dimer interface [polypeptide binding]; other site
693979007950	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
693979007951	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
693979007952	homodimer interface [polypeptide binding]; other site
693979007953	oligonucleotide binding site [chemical binding]; other site
693979007954	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
693979007955	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979007956	ATP binding site [chemical binding]; other site
693979007957	putative Mg++ binding site [ion binding]; other site
693979007958	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979007959	nucleotide binding region [chemical binding]; other site
693979007960	ATP-binding site [chemical binding]; other site
693979007961	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
693979007962	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
693979007963	Mg++ binding site [ion binding]; other site
693979007964	putative catalytic motif [active]
693979007965	substrate binding site [chemical binding]; other site
693979007966	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
693979007967	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
693979007968	NADP-binding site; other site
693979007969	homotetramer interface [polypeptide binding]; other site
693979007970	substrate binding site [chemical binding]; other site
693979007971	homodimer interface [polypeptide binding]; other site
693979007972	active site
693979007973	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
693979007974	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
693979007975	metal-binding site
693979007976	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
693979007977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979007978	NAD(P) binding site [chemical binding]; other site
693979007979	active site
693979007980	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
693979007981	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
693979007982	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
693979007983	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
693979007984	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
693979007985	active site
693979007986	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
693979007987	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
693979007988	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979007989	Coenzyme A binding pocket [chemical binding]; other site
693979007990	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
693979007991	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
693979007992	inhibitor-cofactor binding pocket; inhibition site
693979007993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979007994	catalytic residue [active]
693979007995	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
693979007996	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
693979007997	substrate binding site [chemical binding]; other site
693979007998	trimer interface [polypeptide binding]; other site
693979007999	oxyanion hole (OAH) forming residues; other site
693979008000	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
693979008001	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979008002	NAD(P) binding site [chemical binding]; other site
693979008003	active site
693979008004	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
693979008005	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
693979008006	dimer interface [polypeptide binding]; other site
693979008007	active site
693979008008	CoA binding pocket [chemical binding]; other site
693979008009	WxcM-like, C-terminal; Region: FdtA; pfam05523
693979008010	WxcM-like, C-terminal; Region: FdtA; pfam05523
693979008011	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
693979008012	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
693979008013	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979008014	active site
693979008015	DNA binding site [nucleotide binding]
693979008016	Int/Topo IB signature motif; other site
693979008017	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
693979008018	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
693979008019	dimer interface [polypeptide binding]; other site
693979008020	active site
693979008021	metal binding site [ion binding]; metal-binding site
693979008022	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
693979008023	active site
693979008024	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
693979008025	Predicted membrane protein [Function unknown]; Region: COG2246
693979008026	GtrA-like protein; Region: GtrA; pfam04138
693979008027	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
693979008028	tetramer interfaces [polypeptide binding]; other site
693979008029	binuclear metal-binding site [ion binding]; other site
693979008030	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
693979008031	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008032	sensory histidine kinase AtoS; Provisional; Region: PRK11360
693979008033	HAMP domain; Region: HAMP; pfam00672
693979008034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
693979008035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008036	ATP binding site [chemical binding]; other site
693979008037	Mg2+ binding site [ion binding]; other site
693979008038	G-X-G motif; other site
693979008039	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
693979008040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008041	active site
693979008042	phosphorylation site [posttranslational modification]
693979008043	intermolecular recognition site; other site
693979008044	dimerization interface [polypeptide binding]; other site
693979008045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
693979008046	Walker A motif; other site
693979008047	ATP binding site [chemical binding]; other site
693979008048	Walker B motif; other site
693979008049	arginine finger; other site
693979008050	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
693979008051	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
693979008052	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
693979008053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979008054	active site
693979008055	motif I; other site
693979008056	motif II; other site
693979008057	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
693979008058	putative active site pocket [active]
693979008059	4-fold oligomerization interface [polypeptide binding]; other site
693979008060	metal binding residues [ion binding]; metal-binding site
693979008061	3-fold/trimer interface [polypeptide binding]; other site
693979008062	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
693979008063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979008064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979008065	homodimer interface [polypeptide binding]; other site
693979008066	catalytic residue [active]
693979008067	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
693979008068	histidinol dehydrogenase; Region: hisD; TIGR00069
693979008069	NAD binding site [chemical binding]; other site
693979008070	dimerization interface [polypeptide binding]; other site
693979008071	product binding site; other site
693979008072	substrate binding site [chemical binding]; other site
693979008073	zinc binding site [ion binding]; other site
693979008074	catalytic residues [active]
693979008075	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
693979008076	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
693979008077	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
693979008078	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
693979008079	CoenzymeA binding site [chemical binding]; other site
693979008080	subunit interaction site [polypeptide binding]; other site
693979008081	PHB binding site; other site
693979008082	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693979008083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979008084	putative substrate translocation pore; other site
693979008085	Domain of unknown function (DUF718); Region: DUF718; pfam05336
693979008086	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
693979008087	N- and C-terminal domain interface [polypeptide binding]; other site
693979008088	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
693979008089	active site
693979008090	putative catalytic site [active]
693979008091	metal binding site [ion binding]; metal-binding site
693979008092	ATP binding site [chemical binding]; other site
693979008093	carbohydrate binding site [chemical binding]; other site
693979008094	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
693979008095	active site
693979008096	intersubunit interface [polypeptide binding]; other site
693979008097	Zn2+ binding site [ion binding]; other site
693979008098	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
693979008099	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
693979008100	dimer interface [polypeptide binding]; other site
693979008101	active site
693979008102	metal binding site [ion binding]; metal-binding site
693979008103	L-fucose isomerase; Provisional; Region: fucI; PRK10991
693979008104	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
693979008105	hexamer (dimer of trimers) interface [polypeptide binding]; other site
693979008106	trimer interface [polypeptide binding]; other site
693979008107	substrate binding site [chemical binding]; other site
693979008108	Mn binding site [ion binding]; other site
693979008109	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
693979008110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
693979008111	DNA-binding site [nucleotide binding]; DNA binding site
693979008112	Transcriptional regulators [Transcription]; Region: PurR; COG1609
693979008113	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
693979008114	putative dimerization interface [polypeptide binding]; other site
693979008115	putative ligand binding site [chemical binding]; other site
693979008116	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979008117	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
693979008118	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
693979008119	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
693979008120	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
693979008121	catalytic residues [active]
693979008122	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
693979008123	Chloramphenicol acetyltransferase; Region: CAT; cl02008
693979008124	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
693979008125	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
693979008126	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
693979008127	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
693979008128	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
693979008129	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
693979008130	ATP-binding site [chemical binding]; other site
693979008131	Sugar specificity; other site
693979008132	Pyrimidine base specificity; other site
693979008133	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
693979008134	substrate binding pocket [chemical binding]; other site
693979008135	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
693979008136	membrane-bound complex binding site; other site
693979008137	hinge residues; other site
693979008138	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
693979008139	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
693979008140	N-acetyl-D-glucosamine binding site [chemical binding]; other site
693979008141	catalytic residue [active]
693979008142	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
693979008143	Penicillinase repressor; Region: Pencillinase_R; pfam03965
693979008144	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
693979008145	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
693979008146	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
693979008147	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
693979008148	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
693979008149	substrate binding pocket [chemical binding]; other site
693979008150	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
693979008151	B12 binding site [chemical binding]; other site
693979008152	cobalt ligand [ion binding]; other site
693979008153	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
693979008154	SmpB-tmRNA interface; other site
693979008155	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
693979008156	NigD-like protein; Region: NigD; pfam12667
693979008157	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
693979008158	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
693979008159	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
693979008160	GGGtGRT protein; Region: GGGtGRT; pfam14057
693979008161	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008162	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
693979008163	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
693979008164	putative active site [active]
693979008165	metal binding site [ion binding]; metal-binding site
693979008166	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008168	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
693979008169	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
693979008170	Uncharacterized conserved protein [Function unknown]; Region: COG4925
693979008171	maltose O-acetyltransferase; Provisional; Region: PRK10092
693979008172	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
693979008173	trimer interface [polypeptide binding]; other site
693979008174	active site
693979008175	substrate binding site [chemical binding]; other site
693979008176	CoA binding site [chemical binding]; other site
693979008177	Domain of unknown function (DUF362); Region: DUF362; pfam04015
693979008178	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
693979008179	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979008180	N-terminal plug; other site
693979008181	ligand-binding site [chemical binding]; other site
693979008182	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
693979008183	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
693979008184	DNA binding residues [nucleotide binding]
693979008185	dimerization interface [polypeptide binding]; other site
693979008186	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
693979008187	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
693979008188	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
693979008189	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
693979008190	homodimer interface [polypeptide binding]; other site
693979008191	substrate-cofactor binding pocket; other site
693979008192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979008193	catalytic residue [active]
693979008194	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
693979008195	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
693979008196	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
693979008197	Catalytic dyad [active]
693979008198	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
693979008199	Putative esterase; Region: Esterase; pfam00756
693979008200	S-formylglutathione hydrolase; Region: PLN02442
693979008201	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
693979008202	Domain of unknown function DUF21; Region: DUF21; pfam01595
693979008203	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
693979008204	Transporter associated domain; Region: CorC_HlyC; smart01091
693979008205	NlpE N-terminal domain; Region: NlpE; pfam04170
693979008206	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
693979008207	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
693979008208	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
693979008209	metal binding site [ion binding]; metal-binding site
693979008210	dimer interface [polypeptide binding]; other site
693979008211	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
693979008212	putative catalytic site [active]
693979008213	putative metal binding site [ion binding]; other site
693979008214	putative phosphate binding site [ion binding]; other site
693979008215	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
693979008216	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979008217	active site
693979008218	Sulfatase; Region: Sulfatase; pfam00884
693979008219	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
693979008220	active site
693979008221	intersubunit interactions; other site
693979008222	catalytic residue [active]
693979008223	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
693979008224	binding surface
693979008225	TPR motif; other site
693979008226	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
693979008227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979008228	Walker A/P-loop; other site
693979008229	ATP binding site [chemical binding]; other site
693979008230	Q-loop/lid; other site
693979008231	ABC transporter signature motif; other site
693979008232	Walker B; other site
693979008233	D-loop; other site
693979008234	H-loop/switch region; other site
693979008235	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979008236	Walker A/P-loop; other site
693979008237	ATP binding site [chemical binding]; other site
693979008238	Q-loop/lid; other site
693979008239	ABC transporter signature motif; other site
693979008240	Walker B; other site
693979008241	D-loop; other site
693979008242	H-loop/switch region; other site
693979008243	pullulanase, type I; Region: pulA_typeI; TIGR02104
693979008244	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
693979008245	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
693979008246	Ca binding site [ion binding]; other site
693979008247	active site
693979008248	catalytic site [active]
693979008249	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
693979008250	active site
693979008251	putative DNA-binding cleft [nucleotide binding]; other site
693979008252	dimer interface [polypeptide binding]; other site
693979008253	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
693979008254	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979008255	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979008256	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008257	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008258	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979008259	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979008260	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008261	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
693979008262	active site
693979008263	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
693979008264	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
693979008265	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
693979008266	dimer interface [polypeptide binding]; other site
693979008267	motif 1; other site
693979008268	active site
693979008269	motif 2; other site
693979008270	motif 3; other site
693979008271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979008272	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979008273	putative substrate translocation pore; other site
693979008274	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
693979008275	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
693979008276	minor groove reading motif; other site
693979008277	helix-hairpin-helix signature motif; other site
693979008278	substrate binding pocket [chemical binding]; other site
693979008279	active site
693979008280	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
693979008281	Phosphoglycerate kinase; Region: PGK; pfam00162
693979008282	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
693979008283	substrate binding site [chemical binding]; other site
693979008284	hinge regions; other site
693979008285	ADP binding site [chemical binding]; other site
693979008286	catalytic site [active]
693979008287	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
693979008288	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
693979008289	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
693979008290	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
693979008291	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
693979008292	transmembrane helices; other site
693979008293	TPR repeat; Region: TPR_11; pfam13414
693979008294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979008295	binding surface
693979008296	TPR motif; other site
693979008297	TPR repeat; Region: TPR_11; pfam13414
693979008298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979008299	binding surface
693979008300	TPR motif; other site
693979008301	Maf-like protein; Region: Maf; pfam02545
693979008302	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
693979008303	active site
693979008304	dimer interface [polypeptide binding]; other site
693979008305	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
693979008306	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
693979008307	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
693979008308	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
693979008309	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
693979008310	FMN binding site [chemical binding]; other site
693979008311	dimer interface [polypeptide binding]; other site
693979008312	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
693979008313	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
693979008314	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
693979008315	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
693979008316	active site
693979008317	catalytic site [active]
693979008318	carbohydrate-binding module Fa from Bacteroides thetaiotaomicron SusE, and similar CBMs; Region: CBM-Fa; cd12964
693979008319	starch binding site [chemical binding]; other site
693979008320	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
693979008321	starch binding site [chemical binding]; other site
693979008322	SusE outer membrane protein; Region: SusE; pfam14292
693979008323	carbohydrate-binding modules Eb and Fb from SusE and SusF, respectively, and similar CBMs; Region: CBM-Eb_CBM-Fb; cd12965
693979008324	starch binding site [chemical binding]; other site
693979008325	carbohydrate-binding modules Ec and Fc from SusE and SusF, respectively, and similar CBMs; Region: CBM-Ec_CBM-Fc; cd12966
693979008326	starch binding site [chemical binding]; other site
693979008327	starch-binding loop; other site
693979008328	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979008329	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979008330	SusD family; Region: SusD; pfam07980
693979008331	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008332	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008333	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
693979008334	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008335	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
693979008336	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979008337	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979008338	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008340	dimer interface [polypeptide binding]; other site
693979008341	phosphorylation site [posttranslational modification]
693979008342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008343	ATP binding site [chemical binding]; other site
693979008344	Mg2+ binding site [ion binding]; other site
693979008345	G-X-G motif; other site
693979008346	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008347	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008348	Transcriptional regulators [Transcription]; Region: PurR; COG1609
693979008349	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
693979008350	DNA binding site [nucleotide binding]
693979008351	domain linker motif; other site
693979008352	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
693979008353	dimerization interface [polypeptide binding]; other site
693979008354	ligand binding site [chemical binding]; other site
693979008355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979008356	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979008357	putative substrate translocation pore; other site
693979008358	maltose phosphorylase; Provisional; Region: PRK13807
693979008359	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
693979008360	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
693979008361	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
693979008362	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
693979008363	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
693979008364	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
693979008365	active site
693979008366	catalytic residues [active]
693979008367	metal binding site [ion binding]; metal-binding site
693979008368	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
693979008369	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
693979008370	carboxyltransferase (CT) interaction site; other site
693979008371	biotinylation site [posttranslational modification]; other site
693979008372	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
693979008373	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008374	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
693979008375	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
693979008376	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
693979008377	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
693979008378	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
693979008379	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
693979008380	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
693979008381	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
693979008382	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
693979008383	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
693979008384	BRO family, N-terminal domain; Region: Bro-N; cl10591
693979008385	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
693979008386	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
693979008387	G1 box; other site
693979008388	putative GEF interaction site [polypeptide binding]; other site
693979008389	GTP/Mg2+ binding site [chemical binding]; other site
693979008390	Switch I region; other site
693979008391	G2 box; other site
693979008392	G3 box; other site
693979008393	Switch II region; other site
693979008394	G4 box; other site
693979008395	G5 box; other site
693979008396	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
693979008397	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
693979008398	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
693979008399	NADP binding site [chemical binding]; other site
693979008400	active site
693979008401	putative substrate binding site [chemical binding]; other site
693979008402	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
693979008403	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
693979008404	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
693979008405	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
693979008406	dimerization interface [polypeptide binding]; other site
693979008407	ATP binding site [chemical binding]; other site
693979008408	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
693979008409	dimerization interface [polypeptide binding]; other site
693979008410	ATP binding site [chemical binding]; other site
693979008411	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
693979008412	putative active site [active]
693979008413	catalytic triad [active]
693979008414	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979008415	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979008416	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008418	dimer interface [polypeptide binding]; other site
693979008419	phosphorylation site [posttranslational modification]
693979008420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008421	Mg2+ binding site [ion binding]; other site
693979008422	G-X-G motif; other site
693979008423	Response regulator receiver domain; Region: Response_reg; pfam00072
693979008424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008425	active site
693979008426	phosphorylation site [posttranslational modification]
693979008427	intermolecular recognition site; other site
693979008428	dimerization interface [polypeptide binding]; other site
693979008429	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979008430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008431	Chromate transporter; Region: Chromate_transp; pfam02417
693979008432	Chromate transporter; Region: Chromate_transp; pfam02417
693979008433	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
693979008434	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
693979008435	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
693979008436	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
693979008437	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
693979008438	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008439	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
693979008440	Sulfatase; Region: Sulfatase; cl17466
693979008441	Autotransporter beta-domain; Region: Autotransporter; cl17461
693979008442	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
693979008443	Carbon starvation protein CstA; Region: CstA; pfam02554
693979008444	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
693979008445	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
693979008446	ribonuclease E; Reviewed; Region: rne; PRK10811
693979008447	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008448	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
693979008449	AAA domain; Region: AAA_14; pfam13173
693979008450	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
693979008451	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
693979008452	dimer interface [polypeptide binding]; other site
693979008453	PYR/PP interface [polypeptide binding]; other site
693979008454	TPP binding site [chemical binding]; other site
693979008455	substrate binding site [chemical binding]; other site
693979008456	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
693979008457	Domain of unknown function; Region: EKR; smart00890
693979008458	4Fe-4S binding domain; Region: Fer4_6; pfam12837
693979008459	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
693979008460	TPP-binding site [chemical binding]; other site
693979008461	dimer interface [polypeptide binding]; other site
693979008462	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008463	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979008464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008466	dimer interface [polypeptide binding]; other site
693979008467	phosphorylation site [posttranslational modification]
693979008468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008469	ATP binding site [chemical binding]; other site
693979008470	Mg2+ binding site [ion binding]; other site
693979008471	G-X-G motif; other site
693979008472	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008473	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979008474	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008475	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
693979008476	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
693979008477	active site
693979008478	catalytic tetrad [active]
693979008479	Amidohydrolase; Region: Amidohydro_2; pfam04909
693979008480	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
693979008481	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
693979008482	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
693979008483	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
693979008484	putative substrate binding site [chemical binding]; other site
693979008485	putative ATP binding site [chemical binding]; other site
693979008486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
693979008487	Major Facilitator Superfamily; Region: MFS_1; pfam07690
693979008488	putative substrate translocation pore; other site
693979008489	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
693979008490	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
693979008491	substrate binding [chemical binding]; other site
693979008492	active site
693979008493	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
693979008494	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
693979008495	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
693979008496	active site
693979008497	nucleophile elbow; other site
693979008498	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
693979008499	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
693979008500	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
693979008501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008502	active site
693979008503	phosphorylation site [posttranslational modification]
693979008504	intermolecular recognition site; other site
693979008505	dimerization interface [polypeptide binding]; other site
693979008506	LytTr DNA-binding domain; Region: LytTR; smart00850
693979008507	Histidine kinase; Region: His_kinase; pfam06580
693979008508	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
693979008509	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
693979008510	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
693979008511	putative metal binding residues [ion binding]; other site
693979008512	signature motif; other site
693979008513	dimer interface [polypeptide binding]; other site
693979008514	active site
693979008515	polyP binding site; other site
693979008516	substrate binding site [chemical binding]; other site
693979008517	acceptor-phosphate pocket; other site
693979008518	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
693979008519	Ligand binding site [chemical binding]; other site
693979008520	Electron transfer flavoprotein domain; Region: ETF; pfam01012
693979008521	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
693979008522	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
693979008523	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
693979008524	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
693979008525	four helix bundle protein; Region: TIGR02436
693979008526	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
693979008527	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
693979008528	active site
693979008529	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
693979008530	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979008531	Coenzyme A binding pocket [chemical binding]; other site
693979008532	YoaP-like; Region: YoaP; pfam14268
693979008533	DinB superfamily; Region: DinB_2; pfam12867
693979008534	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
693979008535	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
693979008536	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
693979008537	DNA binding residues [nucleotide binding]
693979008538	chaperone protein DnaJ; Provisional; Region: PRK14299
693979008539	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
693979008540	HSP70 interaction site [polypeptide binding]; other site
693979008541	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
693979008542	dimer interface [polypeptide binding]; other site
693979008543	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
693979008544	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
693979008545	tetramer interface [polypeptide binding]; other site
693979008546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979008547	catalytic residue [active]
693979008548	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
693979008549	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
693979008550	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
693979008551	ring oligomerisation interface [polypeptide binding]; other site
693979008552	ATP/Mg binding site [chemical binding]; other site
693979008553	stacking interactions; other site
693979008554	hinge regions; other site
693979008555	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
693979008556	oligomerisation interface [polypeptide binding]; other site
693979008557	mobile loop; other site
693979008558	roof hairpin; other site
693979008559	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979008560	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
693979008561	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
693979008562	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
693979008563	dimer interface [polypeptide binding]; other site
693979008564	motif 1; other site
693979008565	active site
693979008566	motif 2; other site
693979008567	motif 3; other site
693979008568	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
693979008569	anticodon binding site; other site
693979008570	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
693979008571	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
693979008572	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
693979008573	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
693979008574	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
693979008575	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
693979008576	GDP-binding site [chemical binding]; other site
693979008577	ACT binding site; other site
693979008578	IMP binding site; other site
693979008579	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
693979008580	metal binding site 2 [ion binding]; metal-binding site
693979008581	putative DNA binding helix; other site
693979008582	metal binding site 1 [ion binding]; metal-binding site
693979008583	dimer interface [polypeptide binding]; other site
693979008584	structural Zn2+ binding site [ion binding]; other site
693979008585	A new structural DNA glycosylase; Region: AlkD_like; cd06561
693979008586	active site
693979008587	Peptidase family M49; Region: Peptidase_M49; pfam03571
693979008588	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979008589	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
693979008590	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979008591	ATP binding site [chemical binding]; other site
693979008592	putative Mg++ binding site [ion binding]; other site
693979008593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
693979008594	nucleotide binding region [chemical binding]; other site
693979008595	ATP-binding site [chemical binding]; other site
693979008596	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
693979008597	HRDC domain; Region: HRDC; pfam00570
693979008598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
693979008599	binding surface
693979008600	TPR motif; other site
693979008601	TPR repeat; Region: TPR_11; pfam13414
693979008602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979008603	binding surface
693979008604	TPR motif; other site
693979008605	TPR repeat; Region: TPR_11; pfam13414
693979008606	Tetratricopeptide repeat; Region: TPR_16; pfam13432
693979008607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979008608	binding surface
693979008609	TPR motif; other site
693979008610	TPR repeat; Region: TPR_11; pfam13414
693979008611	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
693979008612	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
693979008613	dimer interface [polypeptide binding]; other site
693979008614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979008615	catalytic residue [active]
693979008616	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
693979008617	tartrate dehydrogenase; Region: TTC; TIGR02089
693979008618	(R)-citramalate synthase; Provisional; Region: PRK09389
693979008619	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
693979008620	active site
693979008621	catalytic residues [active]
693979008622	metal binding site [ion binding]; metal-binding site
693979008623	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
693979008624	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
693979008625	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
693979008626	substrate binding site [chemical binding]; other site
693979008627	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
693979008628	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
693979008629	substrate binding site [chemical binding]; other site
693979008630	ligand binding site [chemical binding]; other site
693979008631	2-isopropylmalate synthase; Validated; Region: PRK00915
693979008632	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
693979008633	active site
693979008634	catalytic residues [active]
693979008635	metal binding site [ion binding]; metal-binding site
693979008636	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
693979008637	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
693979008638	tandem repeat interface [polypeptide binding]; other site
693979008639	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
693979008640	oligomer interface [polypeptide binding]; other site
693979008641	active site residues [active]
693979008642	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
693979008643	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
693979008644	oligomer interface [polypeptide binding]; other site
693979008645	tandem repeat interface [polypeptide binding]; other site
693979008646	active site residues [active]
693979008647	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
693979008648	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
693979008649	purine nucleoside phosphorylase; Provisional; Region: PRK08202
693979008650	thiamine monophosphate kinase; Provisional; Region: PRK05731
693979008651	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
693979008652	ATP binding site [chemical binding]; other site
693979008653	dimerization interface [polypeptide binding]; other site
693979008654	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
693979008655	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
693979008656	Int/Topo IB signature motif; other site
693979008657	Helix-turn-helix domain; Region: HTH_17; pfam12728
693979008658	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
693979008659	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979008660	active site
693979008661	DNA binding site [nucleotide binding]
693979008662	Int/Topo IB signature motif; other site
693979008663	DEAD-like helicases superfamily; Region: DEXDc; smart00487
693979008664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
693979008665	ATP binding site [chemical binding]; other site
693979008666	putative Mg++ binding site [ion binding]; other site
693979008667	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
693979008668	TIGR02646 family protein; Region: TIGR02646
693979008669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979008670	Walker A/P-loop; other site
693979008671	ATP binding site [chemical binding]; other site
693979008672	RloB-like protein; Region: RloB; pfam13707
693979008673	Predicted ATPases [General function prediction only]; Region: COG1106
693979008674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
693979008675	Walker A/P-loop; other site
693979008676	ATP binding site [chemical binding]; other site
693979008677	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
693979008678	Uncharacterized conserved protein [Function unknown]; Region: COG1359
693979008679	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
693979008680	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
693979008681	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
693979008682	active site
693979008683	metal binding site [ion binding]; metal-binding site
693979008684	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
693979008685	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
693979008686	homodimer interface [polypeptide binding]; other site
693979008687	substrate-cofactor binding pocket; other site
693979008688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979008689	catalytic residue [active]
693979008690	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
693979008691	Malic enzyme, N-terminal domain; Region: malic; pfam00390
693979008692	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
693979008693	putative NAD(P) binding site [chemical binding]; other site
693979008694	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
693979008695	glutamate dehydrogenase; Provisional; Region: PRK14031
693979008696	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
693979008697	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
693979008698	NAD(P) binding site [chemical binding]; other site
693979008699	Outer membrane efflux protein; Region: OEP; pfam02321
693979008700	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
693979008701	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
693979008702	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979008703	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
693979008704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
693979008705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008706	active site
693979008707	phosphorylation site [posttranslational modification]
693979008708	intermolecular recognition site; other site
693979008709	dimerization interface [polypeptide binding]; other site
693979008710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
693979008711	DNA binding site [nucleotide binding]
693979008712	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008713	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008714	dimer interface [polypeptide binding]; other site
693979008715	phosphorylation site [posttranslational modification]
693979008716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008717	ATP binding site [chemical binding]; other site
693979008718	Mg2+ binding site [ion binding]; other site
693979008719	G-X-G motif; other site
693979008720	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008721	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979008722	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008723	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
693979008724	active site
693979008725	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
693979008726	short chain dehydrogenase; Provisional; Region: PRK06940
693979008727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979008728	NAD(P) binding site [chemical binding]; other site
693979008729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
693979008730	NAD(P) binding site [chemical binding]; other site
693979008731	active site
693979008732	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
693979008733	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979008734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008735	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
693979008736	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
693979008737	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
693979008738	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
693979008739	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
693979008740	active site
693979008741	(T/H)XGH motif; other site
693979008742	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
693979008743	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
693979008744	catalytic site [active]
693979008745	G-X2-G-X-G-K; other site
693979008746	hypothetical protein; Provisional; Region: PRK11820
693979008747	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
693979008748	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
693979008749	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
693979008750	Glycoprotease family; Region: Peptidase_M22; pfam00814
693979008751	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
693979008752	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
693979008753	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
693979008754	hinge; other site
693979008755	active site
693979008756	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
693979008757	RimM N-terminal domain; Region: RimM; pfam01782
693979008758	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
693979008759	Peptidase family M23; Region: Peptidase_M23; pfam01551
693979008760	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
693979008761	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
693979008762	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
693979008763	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
693979008764	RIP metalloprotease RseP; Region: TIGR00054
693979008765	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
693979008766	active site
693979008767	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
693979008768	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
693979008769	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
693979008770	putative substrate binding region [chemical binding]; other site
693979008771	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
693979008772	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
693979008773	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
693979008774	RuvA N terminal domain; Region: RuvA_N; pfam01330
693979008775	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
693979008776	Protein of unknown function (DUF3843); Region: DUF3843; pfam12954
693979008777	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
693979008778	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
693979008779	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
693979008780	active site
693979008781	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
693979008782	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
693979008783	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
693979008784	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
693979008785	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
693979008786	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
693979008787	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008788	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
693979008789	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979008790	N-terminal plug; other site
693979008791	ligand-binding site [chemical binding]; other site
693979008792	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
693979008793	glutamate dehydrogenase; Provisional; Region: PRK14030
693979008794	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
693979008795	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
693979008796	NAD(P) binding site [chemical binding]; other site
693979008797	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
693979008798	Trehalose utilisation; Region: ThuA; pfam06283
693979008799	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
693979008800	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008801	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008802	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
693979008803	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
693979008804	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
693979008805	ligand binding site [chemical binding]; other site
693979008806	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
693979008807	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979008808	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979008809	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979008810	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979008811	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
693979008812	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
693979008813	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
693979008814	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008815	IPT/TIG domain; Region: TIG; pfam01833
693979008816	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
693979008817	starch binding outer membrane protein SusD; Region: SusD; cd08977
693979008818	SusD family; Region: SusD; pfam07980
693979008819	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979008820	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008821	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008822	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979008823	SusD family; Region: SusD; pfam07980
693979008824	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008825	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008826	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979008827	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008828	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
693979008829	Glyco_18 domain; Region: Glyco_18; smart00636
693979008830	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
693979008831	active site
693979008832	Trehalose utilisation; Region: ThuA; pfam06283
693979008833	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
693979008834	L-fucose transporter; Provisional; Region: PRK10133; cl17665
693979008835	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
693979008836	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
693979008837	active site
693979008838	trimer interface [polypeptide binding]; other site
693979008839	allosteric site; other site
693979008840	active site lid [active]
693979008841	hexamer (dimer of trimers) interface [polypeptide binding]; other site
693979008842	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
693979008843	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
693979008844	nucleotide binding site [chemical binding]; other site
693979008845	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
693979008846	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
693979008847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008849	dimer interface [polypeptide binding]; other site
693979008850	phosphorylation site [posttranslational modification]
693979008851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008852	ATP binding site [chemical binding]; other site
693979008853	Mg2+ binding site [ion binding]; other site
693979008854	G-X-G motif; other site
693979008855	Response regulator receiver domain; Region: Response_reg; pfam00072
693979008856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008857	active site
693979008858	phosphorylation site [posttranslational modification]
693979008859	intermolecular recognition site; other site
693979008860	dimerization interface [polypeptide binding]; other site
693979008861	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
693979008862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008864	intermolecular recognition site; other site
693979008865	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
693979008866	Helix-turn-helix domain; Region: HTH_18; pfam12833
693979008867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
693979008868	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
693979008869	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
693979008870	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
693979008871	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
693979008872	UbiA prenyltransferase family; Region: UbiA; pfam01040
693979008873	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
693979008874	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
693979008875	NAD binding site [chemical binding]; other site
693979008876	substrate binding site [chemical binding]; other site
693979008877	homodimer interface [polypeptide binding]; other site
693979008878	active site
693979008879	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
693979008880	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
693979008881	substrate binding site; other site
693979008882	tetramer interface; other site
693979008883	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979008884	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979008885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
693979008886	binding surface
693979008887	TPR motif; other site
693979008888	Tetratricopeptide repeat; Region: TPR_12; pfam13424
693979008889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
693979008890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
693979008891	dimer interface [polypeptide binding]; other site
693979008892	phosphorylation site [posttranslational modification]
693979008893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
693979008894	ATP binding site [chemical binding]; other site
693979008895	Mg2+ binding site [ion binding]; other site
693979008896	G-X-G motif; other site
693979008897	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
693979008898	active site
693979008899	metal binding site [ion binding]; metal-binding site
693979008900	homotetramer interface [polypeptide binding]; other site
693979008901	polyphosphate kinase; Provisional; Region: PRK05443
693979008902	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
693979008903	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
693979008904	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
693979008905	domain interface [polypeptide binding]; other site
693979008906	active site
693979008907	catalytic site [active]
693979008908	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
693979008909	domain interface [polypeptide binding]; other site
693979008910	active site
693979008911	catalytic site [active]
693979008912	Phosphate transporter family; Region: PHO4; pfam01384
693979008913	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
693979008914	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
693979008915	active site
693979008916	NTP binding site [chemical binding]; other site
693979008917	metal binding triad [ion binding]; metal-binding site
693979008918	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
693979008919	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693979008920	Zn2+ binding site [ion binding]; other site
693979008921	Mg2+ binding site [ion binding]; other site
693979008922	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
693979008923	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
693979008924	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979008925	SusD family; Region: SusD; pfam07980
693979008926	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008927	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008928	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979008929	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008930	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
693979008931	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008932	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
693979008933	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
693979008934	starch binding outer membrane protein SusD; Region: SusD; cl17845
693979008935	Lipid-binding putative hydrolase; Region: Lipid_bd; pfam12888
693979008936	Response regulator receiver domain; Region: Response_reg; pfam00072
693979008937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
693979008938	active site
693979008939	phosphorylation site [posttranslational modification]
693979008940	intermolecular recognition site; other site
693979008941	dimerization interface [polypeptide binding]; other site
693979008942	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
693979008943	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979008944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979008945	ABC transporter; Region: ABC_tran_2; pfam12848
693979008946	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
693979008947	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
693979008948	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
693979008949	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
693979008950	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
693979008951	HlyD family secretion protein; Region: HlyD_3; pfam13437
693979008952	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
693979008953	Outer membrane efflux protein; Region: OEP; pfam02321
693979008954	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
693979008955	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
693979008956	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
693979008957	Cna protein B-type domain; Region: Cna_B_2; pfam13715
693979008958	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
693979008959	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
693979008960	N-terminal plug; other site
693979008961	ligand-binding site [chemical binding]; other site
693979008962	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
693979008963	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
693979008964	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
693979008965	DNA binding residues [nucleotide binding]
693979008966	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
693979008967	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
693979008968	putative active site [active]
693979008969	catalytic site [active]
693979008970	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
693979008971	putative active site [active]
693979008972	catalytic site [active]
693979008973	thymidylate synthase; Reviewed; Region: thyA; PRK01827
693979008974	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
693979008975	dimerization interface [polypeptide binding]; other site
693979008976	active site
693979008977	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
693979008978	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
693979008979	folate binding site [chemical binding]; other site
693979008980	NADP+ binding site [chemical binding]; other site
693979008981	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
693979008982	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
693979008983	AsnC family; Region: AsnC_trans_reg; pfam01037
693979008984	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
693979008985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
693979008986	Coenzyme A binding pocket [chemical binding]; other site
693979008987	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
693979008988	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
693979008989	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
693979008990	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
693979008991	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
693979008992	active site
693979008993	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
693979008994	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
693979008995	substrate binding pocket [chemical binding]; other site
693979008996	chain length determination region; other site
693979008997	substrate-Mg2+ binding site; other site
693979008998	catalytic residues [active]
693979008999	aspartate-rich region 1; other site
693979009000	active site lid residues [active]
693979009001	aspartate-rich region 2; other site
693979009002	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
693979009003	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
693979009004	cytidylate kinase; Provisional; Region: cmk; PRK00023
693979009005	AAA domain; Region: AAA_17; pfam13207
693979009006	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
693979009007	CMP-binding site; other site
693979009008	The sites determining sugar specificity; other site
693979009009	LytB protein; Region: LYTB; cl00507
693979009010	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
693979009011	6-phosphofructokinase; Provisional; Region: PRK03202
693979009012	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
693979009013	active site
693979009014	ADP/pyrophosphate binding site [chemical binding]; other site
693979009015	dimerization interface [polypeptide binding]; other site
693979009016	allosteric effector site; other site
693979009017	fructose-1,6-bisphosphate binding site; other site
693979009018	citrate synthase; Provisional; Region: PRK14032
693979009019	Citrate synthase; Region: Citrate_synt; pfam00285
693979009020	oxalacetate binding site [chemical binding]; other site
693979009021	citrylCoA binding site [chemical binding]; other site
693979009022	coenzyme A binding site [chemical binding]; other site
693979009023	catalytic triad [active]
693979009024	isocitrate dehydrogenase; Validated; Region: PRK06451
693979009025	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
693979009026	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
693979009027	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
693979009028	substrate binding site [chemical binding]; other site
693979009029	ligand binding site [chemical binding]; other site
693979009030	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
693979009031	substrate binding site [chemical binding]; other site
693979009032	AAA domain; Region: AAA_11; pfam13086
693979009033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
693979009034	ATP binding site [chemical binding]; other site
693979009035	AAA domain; Region: AAA_30; pfam13604
693979009036	AAA domain; Region: AAA_12; pfam13087
693979009037	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
693979009038	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
693979009039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
693979009040	homodimer interface [polypeptide binding]; other site
693979009041	catalytic residue [active]
693979009042	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
693979009043	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
693979009044	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
693979009045	catalytic residue [active]
693979009046	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
693979009047	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
693979009048	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
693979009049	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
693979009050	active site
693979009051	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
693979009052	active site 2 [active]
693979009053	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
693979009054	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
693979009055	putative valine binding site [chemical binding]; other site
693979009056	dimer interface [polypeptide binding]; other site
693979009057	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
693979009058	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
693979009059	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
693979009060	PYR/PP interface [polypeptide binding]; other site
693979009061	dimer interface [polypeptide binding]; other site
693979009062	TPP binding site [chemical binding]; other site
693979009063	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
693979009064	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
693979009065	TPP-binding site [chemical binding]; other site
693979009066	dimer interface [polypeptide binding]; other site
693979009067	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
693979009068	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
693979009069	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
693979009070	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
693979009071	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
693979009072	Tetramer interface [polypeptide binding]; other site
693979009073	active site
693979009074	FMN-binding site [chemical binding]; other site
693979009075	hypothetical protein; Provisional; Region: PRK08201
693979009076	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
693979009077	metal binding site [ion binding]; metal-binding site
693979009078	putative dimer interface [polypeptide binding]; other site
693979009079	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
693979009080	dimer interface [polypeptide binding]; other site
693979009081	ADP-ribose binding site [chemical binding]; other site
693979009082	active site
693979009083	nudix motif; other site
693979009084	metal binding site [ion binding]; metal-binding site
693979009085	DNA topoisomerase III; Provisional; Region: PRK07726
693979009086	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
693979009087	active site
693979009088	putative interdomain interaction site [polypeptide binding]; other site
693979009089	putative metal-binding site [ion binding]; other site
693979009090	putative nucleotide binding site [chemical binding]; other site
693979009091	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
693979009092	domain I; other site
693979009093	DNA binding groove [nucleotide binding]
693979009094	phosphate binding site [ion binding]; other site
693979009095	domain II; other site
693979009096	domain III; other site
693979009097	nucleotide binding site [chemical binding]; other site
693979009098	catalytic site [active]
693979009099	domain IV; other site
693979009100	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
693979009101	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
693979009102	active site
693979009103	substrate binding site [chemical binding]; other site
693979009104	coenzyme B12 binding site [chemical binding]; other site
693979009105	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
693979009106	B12 binding site [chemical binding]; other site
693979009107	cobalt ligand [ion binding]; other site
693979009108	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
693979009109	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
693979009110	heterodimer interface [polypeptide binding]; other site
693979009111	substrate interaction site [chemical binding]; other site
693979009112	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
693979009113	putative transporter; Validated; Region: PRK03818
693979009114	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
693979009115	TrkA-C domain; Region: TrkA_C; pfam02080
693979009116	TrkA-C domain; Region: TrkA_C; pfam02080
693979009117	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
693979009118	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
693979009119	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
693979009120	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
693979009121	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
693979009122	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
693979009123	dimer interface [polypeptide binding]; other site
693979009124	putative anticodon binding site; other site
693979009125	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
693979009126	motif 1; other site
693979009127	active site
693979009128	motif 2; other site
693979009129	motif 3; other site
693979009130	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
693979009131	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
693979009132	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
693979009133	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
693979009134	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
693979009135	active site
693979009136	dimer interface [polypeptide binding]; other site
693979009137	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
693979009138	dimer interface [polypeptide binding]; other site
693979009139	active site
693979009140	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
693979009141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
693979009142	motif II; other site
693979009143	asparagine synthetase AsnA; Provisional; Region: PRK05425
693979009144	motif 1; other site
693979009145	dimer interface [polypeptide binding]; other site
693979009146	active site
693979009147	motif 2; other site
693979009148	motif 3; other site
693979009149	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
693979009150	ligand binding site [chemical binding]; other site
693979009151	active site
693979009152	UGI interface [polypeptide binding]; other site
693979009153	catalytic site [active]
693979009154	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
693979009155	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
693979009156	Zn2+ binding site [ion binding]; other site
693979009157	Mg2+ binding site [ion binding]; other site
693979009158	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
693979009159	putative active site [active]
693979009160	putative catalytic site [active]
693979009161	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
693979009162	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
693979009163	Ligand binding site; other site
693979009164	Putative Catalytic site; other site
693979009165	DXD motif; other site
693979009166	Predicted membrane protein [Function unknown]; Region: COG2246
693979009167	GtrA-like protein; Region: GtrA; pfam04138
693979009168	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
693979009169	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
693979009170	active site
693979009171	metal binding site [ion binding]; metal-binding site
693979009172	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
693979009173	mce related protein; Region: MCE; pfam02470