-- dump date 20140619_000610 -- class Genbank::misc_feature -- table misc_feature_note -- id note 226186000001 Uncharacterized proteins similar to DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF_like; cd13833 226186000002 homodimer interface [polypeptide binding]; other site 226186000003 putative DNA binding site [nucleotide binding]; other site 226186000004 The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843 226186000005 Protein of unknown function, DUF393; Region: DUF393; cl01136 226186000006 30S ribosomal protein S17; Region: S17_bact; TIGR03635 226186000007 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226186000008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186000009 dimer interface [polypeptide binding]; other site 226186000010 phosphorylation site [posttranslational modification] 226186000011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186000012 ATP binding site [chemical binding]; other site 226186000013 Mg2+ binding site [ion binding]; other site 226186000014 G-X-G motif; other site 226186000015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186000016 active site 226186000017 phosphorylation site [posttranslational modification] 226186000018 intermolecular recognition site; other site 226186000019 dimerization interface [polypeptide binding]; other site 226186000020 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186000021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186000022 active site 226186000023 phosphorylation site [posttranslational modification] 226186000024 intermolecular recognition site; other site 226186000025 dimerization interface [polypeptide binding]; other site 226186000026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186000027 Walker A motif; other site 226186000028 ATP binding site [chemical binding]; other site 226186000029 Walker B motif; other site 226186000030 arginine finger; other site 226186000031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186000032 RteC protein; Region: RteC; pfam09357 226186000033 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186000034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186000035 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186000036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186000037 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186000038 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186000039 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186000040 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 226186000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 226186000042 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 226186000043 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000044 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000045 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000047 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000048 SusD family; Region: SusD; pfam07980 226186000049 Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112 226186000050 PHP domain; Region: PHP; pfam02811 226186000051 active site 226186000052 dimer interface [polypeptide binding]; other site 226186000053 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 226186000054 Transposase domain (DUF772); Region: DUF772; pfam05598 226186000055 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 226186000056 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186000057 active site 226186000058 DNA binding site [nucleotide binding] 226186000059 Int/Topo IB signature motif; other site 226186000060 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 226186000061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186000062 active site 226186000063 motif I; other site 226186000064 motif II; other site 226186000065 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186000066 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186000067 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186000068 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 226186000069 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 226186000070 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 226186000071 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 226186000072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186000073 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186000074 active site 226186000075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186000076 active site 226186000077 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226186000078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186000079 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 226186000080 active site 226186000081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186000082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186000083 active site 226186000084 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 226186000085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186000086 active site 226186000087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186000088 active site 226186000089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186000090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186000091 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 226186000092 putative ADP-binding pocket [chemical binding]; other site 226186000093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186000094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186000095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186000096 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 226186000097 putative ADP-binding pocket [chemical binding]; other site 226186000098 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 226186000099 Mg++ binding site [ion binding]; other site 226186000100 putative catalytic motif [active] 226186000101 putative substrate binding site [chemical binding]; other site 226186000102 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 226186000103 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 226186000104 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 226186000105 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 226186000106 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186000107 SLBB domain; Region: SLBB; pfam10531 226186000108 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 226186000109 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226186000110 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226186000111 AAA domain; Region: AAA_31; pfam13614 226186000112 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 226186000113 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186000114 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186000115 alpha-galactosidase; Region: PLN02808; cl17638 226186000116 OmpA family; Region: OmpA; pfam00691 226186000117 ligand binding site [chemical binding]; other site 226186000118 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 226186000119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186000120 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 226186000121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 226186000122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186000123 ABC transporter signature motif; other site 226186000124 Walker B; other site 226186000125 D-loop; other site 226186000126 H-loop/switch region; other site 226186000127 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226186000128 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226186000129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186000130 Walker A/P-loop; other site 226186000131 ATP binding site [chemical binding]; other site 226186000132 Q-loop/lid; other site 226186000133 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 226186000134 Catalytic site [active] 226186000135 Coenzyme A transferase; Region: CoA_trans; cl17247 226186000136 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186000137 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186000138 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226186000139 Int/Topo IB signature motif; other site 226186000140 ORF6N domain; Region: ORF6N; pfam10543 226186000141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226186000142 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226186000143 MPN+ (JAMM) motif; other site 226186000144 Zinc-binding site [ion binding]; other site 226186000145 Antirestriction protein (ArdA); Region: ArdA; pfam07275 226186000146 Domain of unknown function, B. Theta Gene description (DUF3873); Region: DUF3873; pfam12989 226186000147 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 226186000148 Conjugative transposon protein TraO; Region: TraO; pfam10626 226186000149 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 226186000150 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 226186000151 Protein of unknown function (DUF3989); Region: DUF3989; pfam13150 226186000152 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 226186000153 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 226186000154 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 226186000155 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 226186000156 Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992 226186000157 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186000158 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 226186000159 AAA domain; Region: AAA_22; pfam13401 226186000160 Domain of unknown function DUF87; Region: DUF87; cl19135 226186000161 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 226186000162 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 226186000163 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186000164 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226186000165 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186000166 P-loop; other site 226186000167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226186000168 Magnesium ion binding site [ion binding]; other site 226186000169 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186000170 YWFCY protein; Region: YWFCY; pfam14293 226186000171 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 226186000172 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 226186000173 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 226186000174 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186000175 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226186000176 DNA topoisomerase III; Provisional; Region: PRK07726 226186000177 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226186000178 active site 226186000179 putative interdomain interaction site [polypeptide binding]; other site 226186000180 putative metal-binding site [ion binding]; other site 226186000181 putative nucleotide binding site [chemical binding]; other site 226186000182 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226186000183 domain I; other site 226186000184 DNA binding groove [nucleotide binding] 226186000185 phosphate binding site [ion binding]; other site 226186000186 domain II; other site 226186000187 domain III; other site 226186000188 nucleotide binding site [chemical binding]; other site 226186000189 catalytic site [active] 226186000190 domain IV; other site 226186000191 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226186000192 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 226186000193 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186000194 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 226186000195 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 226186000196 active site 226186000197 metal binding site [ion binding]; metal-binding site 226186000198 interdomain interaction site; other site 226186000199 AAA domain; Region: AAA_25; pfam13481 226186000200 Walker A motif; other site 226186000201 ATP binding site [chemical binding]; other site 226186000202 Walker B motif; other site 226186000203 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186000204 RteC protein; Region: RteC; pfam09357 226186000205 Predicted permeases [General function prediction only]; Region: COG0701 226186000206 MerT mercuric transport protein; Region: MerT; cl03578 226186000207 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 226186000208 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226186000209 active site 226186000210 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 226186000211 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 226186000212 P loop; other site 226186000213 Nucleotide binding site [chemical binding]; other site 226186000214 DTAP/Switch II; other site 226186000215 Switch I; other site 226186000216 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 226186000217 P loop; other site 226186000218 Nucleotide binding site [chemical binding]; other site 226186000219 DTAP/Switch II; other site 226186000220 Switch I; other site 226186000221 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 226186000222 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 226186000223 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 226186000224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226186000225 putative DNA binding site [nucleotide binding]; other site 226186000226 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186000227 putative Zn2+ binding site [ion binding]; other site 226186000228 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 226186000229 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226186000230 dimer interface [polypeptide binding]; other site 226186000231 active site 226186000232 CoA binding pocket [chemical binding]; other site 226186000233 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 226186000234 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 226186000235 putative dimer interface [polypeptide binding]; other site 226186000236 [2Fe-2S] cluster binding site [ion binding]; other site 226186000237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226186000238 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 226186000239 catalytic loop [active] 226186000240 iron binding site [ion binding]; other site 226186000241 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 226186000242 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 226186000243 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226186000244 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 226186000245 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 226186000246 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 226186000247 dimer interface [polypeptide binding]; other site 226186000248 [2Fe-2S] cluster binding site [ion binding]; other site 226186000249 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 226186000250 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 226186000251 SLBB domain; Region: SLBB; pfam10531 226186000252 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 226186000253 4Fe-4S binding domain; Region: Fer4; pfam00037 226186000254 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 226186000255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186000256 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226186000257 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186000258 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 226186000259 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 226186000260 putative metal binding site [ion binding]; other site 226186000261 mannonate dehydratase; Provisional; Region: PRK03906 226186000262 mannonate dehydratase; Region: uxuA; TIGR00695 226186000263 D-mannonate oxidoreductase; Provisional; Region: PRK08277 226186000264 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 226186000265 putative NAD(P) binding site [chemical binding]; other site 226186000266 active site 226186000267 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 226186000268 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186000269 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186000270 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186000271 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186000272 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 226186000273 putative active site [active] 226186000274 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 226186000275 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186000276 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186000277 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186000278 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186000279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186000280 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186000281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186000282 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186000283 DNA binding residues [nucleotide binding] 226186000284 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000285 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000286 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000287 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000288 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186000289 SusD family; Region: SusD; pfam07980 226186000290 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 226186000291 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 226186000292 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 226186000293 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 226186000294 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186000295 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186000296 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 226186000297 active site 226186000298 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226186000299 NlpE N-terminal domain; Region: NlpE; cl19736 226186000300 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226186000301 Domain of unknown function DUF21; Region: DUF21; pfam01595 226186000302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226186000303 Transporter associated domain; Region: CorC_HlyC; smart01091 226186000304 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 226186000305 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000306 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186000307 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000308 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 226186000309 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 226186000310 Putative esterase; Region: Esterase; pfam00756 226186000311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 226186000312 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 226186000313 Domain of unknown function (DUF4595) with porin-like fold; Region: DUF4595; pfam15283 226186000314 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 226186000315 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 226186000316 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226186000317 Catalytic dyad [active] 226186000318 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 226186000319 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226186000320 Ligand Binding Site [chemical binding]; other site 226186000321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186000322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186000323 DNA binding residues [nucleotide binding] 226186000324 dimerization interface [polypeptide binding]; other site 226186000325 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 226186000326 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226186000327 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226186000328 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226186000329 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 226186000330 diiron binding motif [ion binding]; other site 226186000331 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 226186000332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226186000333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186000334 putative substrate translocation pore; other site 226186000335 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 226186000336 Transglycosylase; Region: Transgly; pfam00912 226186000337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226186000338 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 226186000339 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 226186000340 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 226186000341 MG2 domain; Region: A2M_N; pfam01835 226186000342 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 226186000343 Alpha-2-macroglobulin family; Region: A2M; pfam00207 226186000344 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 226186000345 surface patch; other site 226186000346 thioester region; other site 226186000347 specificity defining residues; other site 226186000348 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226186000349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186000350 catalytic residues [active] 226186000351 Protein of unknown function DUF86; Region: DUF86; cl01031 226186000352 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226186000353 active site 226186000354 NTP binding site [chemical binding]; other site 226186000355 metal binding triad [ion binding]; metal-binding site 226186000356 antibiotic binding site [chemical binding]; other site 226186000357 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 226186000358 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 226186000359 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186000360 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 226186000361 active site 226186000362 GGGtGRT protein; Region: GGGtGRT; pfam14057 226186000363 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 226186000364 TIGR03987 family protein; Region: TIGR03987 226186000365 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 226186000366 NigD-like protein; Region: NigD; pfam12667 226186000367 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 226186000368 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 226186000369 SmpB-tmRNA interface; other site 226186000370 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 226186000371 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 226186000372 substrate binding pocket [chemical binding]; other site 226186000373 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 226186000374 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 226186000375 B12 binding site [chemical binding]; other site 226186000376 cobalt ligand [ion binding]; other site 226186000377 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 226186000378 putative FMN binding site [chemical binding]; other site 226186000379 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 226186000380 Na binding site [ion binding]; other site 226186000381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226186000382 substrate binding pocket [chemical binding]; other site 226186000383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226186000384 membrane-bound complex binding site; other site 226186000385 hinge residues; other site 226186000386 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 226186000387 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226186000388 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226186000389 catalytic residue [active] 226186000390 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 226186000391 ATP-binding site [chemical binding]; other site 226186000392 Sugar specificity; other site 226186000393 Pyrimidine base specificity; other site 226186000394 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 226186000395 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 226186000396 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 226186000397 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 226186000398 Pirin; Region: Pirin; pfam02678 226186000399 Pirin-related protein [General function prediction only]; Region: COG1741 226186000400 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186000401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186000402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186000403 DNA binding residues [nucleotide binding] 226186000404 FecR protein; Region: FecR; pfam04773 226186000405 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186000406 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000407 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000408 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000410 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000411 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186000412 Interdomain contacts; other site 226186000413 Cytokine receptor motif; other site 226186000414 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186000415 Interdomain contacts; other site 226186000416 Cytokine receptor motif; other site 226186000417 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 226186000418 Trp docking motif [polypeptide binding]; other site 226186000419 active site 226186000420 PQQ-like domain; Region: PQQ_2; pfam13360 226186000421 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226186000422 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226186000423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 226186000424 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186000425 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 226186000426 putative active site [active] 226186000427 catalytic site [active] 226186000428 putative metal binding site [ion binding]; other site 226186000429 oligomer interface [polypeptide binding]; other site 226186000430 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 226186000431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186000432 putative substrate translocation pore; other site 226186000433 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 226186000434 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186000435 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186000436 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186000437 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 226186000438 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 226186000439 CoenzymeA binding site [chemical binding]; other site 226186000440 subunit interaction site [polypeptide binding]; other site 226186000441 PHB binding site; other site 226186000442 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 226186000443 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 226186000444 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 226186000445 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 226186000446 histidinol dehydrogenase; Region: hisD; TIGR00069 226186000447 NAD binding site [chemical binding]; other site 226186000448 dimerization interface [polypeptide binding]; other site 226186000449 product binding site; other site 226186000450 substrate binding site [chemical binding]; other site 226186000451 zinc binding site [ion binding]; other site 226186000452 catalytic residues [active] 226186000453 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 226186000454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186000455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186000456 homodimer interface [polypeptide binding]; other site 226186000457 catalytic residue [active] 226186000458 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 226186000459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186000460 active site 226186000461 motif I; other site 226186000462 motif II; other site 226186000463 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 226186000464 putative active site pocket [active] 226186000465 4-fold oligomerization interface [polypeptide binding]; other site 226186000466 metal binding residues [ion binding]; metal-binding site 226186000467 3-fold/trimer interface [polypeptide binding]; other site 226186000468 Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170 226186000469 NAD synthetase; Reviewed; Region: nadE; PRK02628 226186000470 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 226186000471 multimer interface [polypeptide binding]; other site 226186000472 active site 226186000473 catalytic triad [active] 226186000474 protein interface 1 [polypeptide binding]; other site 226186000475 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 226186000476 homodimer interface [polypeptide binding]; other site 226186000477 NAD binding pocket [chemical binding]; other site 226186000478 ATP binding pocket [chemical binding]; other site 226186000479 Mg binding site [ion binding]; other site 226186000480 active-site loop [active] 226186000481 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000482 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000483 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000484 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000485 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000486 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186000487 Domain of unknown function (DUF4458); Region: DUF4458; pfam14660 226186000488 Domain of unknown function (DUF4458); Region: DUF4458; pfam14660 226186000489 Leucine rich repeat; Region: LRR_8; pfam13855 226186000490 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186000491 Peptidase S8 family domain in Fervidolysin; Region: Peptidases_S8_Fervidolysin_like; cd07485 226186000492 Subtilase family; Region: Peptidase_S8; pfam00082 226186000493 active site 226186000494 catalytic triad [active] 226186000495 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 226186000496 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 226186000497 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 226186000498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226186000499 metal binding site 2 [ion binding]; metal-binding site 226186000500 putative DNA binding helix; other site 226186000501 metal binding site 1 [ion binding]; metal-binding site 226186000502 dimer interface [polypeptide binding]; other site 226186000503 structural Zn2+ binding site [ion binding]; other site 226186000504 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 226186000505 iron binding site [ion binding]; other site 226186000506 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 226186000507 Rubrerythrin [Energy production and conversion]; Region: COG1592 226186000508 diiron binding motif [ion binding]; other site 226186000509 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226186000510 putative FMN binding site [chemical binding]; other site 226186000511 NADPH bind site [chemical binding]; other site 226186000512 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186000513 catalytic residues [active] 226186000514 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186000515 catalytic residues [active] 226186000516 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 226186000517 AAA domain; Region: AAA_14; pfam13173 226186000518 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186000519 Histidine kinase; Region: His_kinase; pfam06580 226186000520 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186000521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186000522 active site 226186000523 phosphorylation site [posttranslational modification] 226186000524 intermolecular recognition site; other site 226186000525 dimerization interface [polypeptide binding]; other site 226186000526 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186000527 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186000528 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 226186000529 Herpesvirus UL6 like; Region: Herpes_UL6; pfam01763 226186000530 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186000531 DNA binding domain, excisionase family; Region: excise; TIGR01764 226186000532 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186000533 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186000534 Int/Topo IB signature motif; other site 226186000535 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 226186000536 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186000537 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 226186000538 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 226186000539 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186000540 Peptidase S46; Region: Peptidase_S46; pfam10459 226186000541 Peptidase S46; Region: Peptidase_S46; pfam10459 226186000542 anaerobic sulfatase-maturase; Provisional; Region: PRK13745 226186000543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186000544 FeS/SAM binding site; other site 226186000545 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 226186000546 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 226186000547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226186000548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186000549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186000550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186000551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186000552 binding surface 226186000553 TPR motif; other site 226186000554 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 226186000555 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226186000556 putative acyl-acceptor binding pocket; other site 226186000557 exonuclease subunit SbcD; Provisional; Region: PRK10966 226186000558 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226186000559 active site 226186000560 metal binding site [ion binding]; metal-binding site 226186000561 DNA binding site [nucleotide binding] 226186000562 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 226186000563 exonuclease subunit SbcC; Provisional; Region: PRK10246 226186000564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186000565 Walker A/P-loop; other site 226186000566 ATP binding site [chemical binding]; other site 226186000567 Q-loop/lid; other site 226186000568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186000569 ABC transporter signature motif; other site 226186000570 Walker B; other site 226186000571 D-loop; other site 226186000572 H-loop/switch region; other site 226186000573 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226186000574 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186000575 putative active site [active] 226186000576 putative metal binding site [ion binding]; other site 226186000577 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 226186000578 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186000579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186000580 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186000581 DNA binding residues [nucleotide binding] 226186000582 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 226186000583 dihydroorotase; Reviewed; Region: PRK09236 226186000584 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226186000585 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 226186000586 active site 226186000587 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 226186000588 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186000589 Ligand binding site; other site 226186000590 Putative Catalytic site; other site 226186000591 DXD motif; other site 226186000592 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 226186000593 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 226186000594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186000595 ATP binding site [chemical binding]; other site 226186000596 putative Mg++ binding site [ion binding]; other site 226186000597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186000598 nucleotide binding region [chemical binding]; other site 226186000599 ATP-binding site [chemical binding]; other site 226186000600 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 226186000601 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 226186000602 hypothetical protein; Provisional; Region: PRK00955 226186000603 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 226186000604 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 226186000605 Sulfurtransferase TusA; Region: TusA; pfam01206 226186000606 CPxP motif; other site 226186000607 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 226186000608 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226186000609 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 226186000610 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186000611 Interdomain contacts; other site 226186000612 Cytokine receptor motif; other site 226186000613 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 226186000614 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226186000615 active site 226186000616 trimer interface [polypeptide binding]; other site 226186000617 allosteric site; other site 226186000618 active site lid [active] 226186000619 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186000620 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 226186000621 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 226186000622 putative active site [active] 226186000623 catalytic triad [active] 226186000624 dimer interface [polypeptide binding]; other site 226186000625 multimer interface [polypeptide binding]; other site 226186000626 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 226186000627 putative acyl-acceptor binding pocket; other site 226186000628 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186000629 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 226186000630 ATP binding site [chemical binding]; other site 226186000631 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186000632 active site 226186000633 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186000634 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 226186000635 active site 226186000636 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 226186000637 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186000638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186000639 dimer interface [polypeptide binding]; other site 226186000640 phosphorylation site [posttranslational modification] 226186000641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186000642 ATP binding site [chemical binding]; other site 226186000643 Mg2+ binding site [ion binding]; other site 226186000644 G-X-G motif; other site 226186000645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186000647 active site 226186000648 phosphorylation site [posttranslational modification] 226186000649 intermolecular recognition site; other site 226186000650 dimerization interface [polypeptide binding]; other site 226186000651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186000652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186000653 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000654 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000655 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000656 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000657 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000658 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000659 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000660 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000661 Sulfatase; Region: Sulfatase; cl19157 226186000662 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186000663 Peptidase M60-like family; Region: M60-like; cl19940 226186000664 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186000665 Sulfatase; Region: Sulfatase; cl19157 226186000666 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186000667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186000668 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186000669 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 226186000670 DNA binding site [nucleotide binding] 226186000671 dimer interface [polypeptide binding]; other site 226186000672 Virulence-associated protein E; Region: VirE; pfam05272 226186000673 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186000674 14-3-3 domain; Region: 14-3-3; cl02098 226186000675 peptide binding site [polypeptide binding]; other site 226186000676 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 226186000677 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186000678 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186000679 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 226186000680 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000681 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186000682 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186000683 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226186000684 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 226186000685 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186000686 sugar binding site [chemical binding]; other site 226186000687 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186000688 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 226186000689 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186000690 active site 226186000691 catalytic residues [active] 226186000692 DNA binding site [nucleotide binding] 226186000693 Int/Topo IB signature motif; other site 226186000694 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 226186000695 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 226186000696 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186000697 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226186000698 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 226186000699 Walker A/P-loop; other site 226186000700 ATP binding site [chemical binding]; other site 226186000701 Q-loop/lid; other site 226186000702 ABC transporter signature motif; other site 226186000703 Walker B; other site 226186000704 D-loop; other site 226186000705 H-loop/switch region; other site 226186000706 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226186000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186000708 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226186000709 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 226186000710 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 226186000711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226186000712 Outer membrane efflux protein; Region: OEP; pfam02321 226186000713 Outer membrane efflux protein; Region: OEP; pfam02321 226186000714 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186000715 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186000716 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186000717 MMPL family; Region: MMPL; cl14618 226186000718 MMPL family; Region: MMPL; cl14618 226186000719 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186000720 MMPL family; Region: MMPL; cl14618 226186000721 MMPL family; Region: MMPL; cl14618 226186000722 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 226186000723 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226186000724 Walker A/P-loop; other site 226186000725 ATP binding site [chemical binding]; other site 226186000726 Q-loop/lid; other site 226186000727 ABC transporter signature motif; other site 226186000728 Walker B; other site 226186000729 D-loop; other site 226186000730 H-loop/switch region; other site 226186000731 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226186000732 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 226186000733 active site 226186000734 nucleophile elbow; other site 226186000735 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186000736 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186000737 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186000738 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186000739 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 226186000740 MMPL family; Region: MMPL; cl14618 226186000741 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 226186000742 Outer membrane efflux protein; Region: OEP; pfam02321 226186000743 Outer membrane efflux protein; Region: OEP; pfam02321 226186000744 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 226186000745 active site 226186000746 ADP/pyrophosphate binding site [chemical binding]; other site 226186000747 dimerization interface [polypeptide binding]; other site 226186000748 allosteric effector site; other site 226186000749 fructose-1,6-bisphosphate binding site; other site 226186000750 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 226186000751 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226186000752 active site 226186000753 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 226186000754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186000755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186000756 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226186000757 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226186000758 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226186000759 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226186000760 E3 interaction surface; other site 226186000761 lipoyl attachment site [posttranslational modification]; other site 226186000762 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226186000763 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226186000764 tetramer interface [polypeptide binding]; other site 226186000765 TPP-binding site [chemical binding]; other site 226186000766 heterodimer interface [polypeptide binding]; other site 226186000767 phosphorylation loop region [posttranslational modification] 226186000768 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226186000769 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 226186000770 PYR/PP interface [polypeptide binding]; other site 226186000771 dimer interface [polypeptide binding]; other site 226186000772 TPP binding site [chemical binding]; other site 226186000773 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226186000774 flavodoxin FldA; Validated; Region: PRK09267 226186000775 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 226186000776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186000777 S-adenosylmethionine binding site [chemical binding]; other site 226186000778 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186000779 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 226186000780 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000781 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000782 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000783 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000784 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186000785 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186000786 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186000787 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226186000788 nucleoside/Zn binding site; other site 226186000789 dimer interface [polypeptide binding]; other site 226186000790 catalytic motif [active] 226186000791 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186000792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186000793 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226186000794 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 226186000795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186000796 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186000797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226186000798 DNA binding residues [nucleotide binding] 226186000799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226186000800 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226186000801 substrate binding pocket [chemical binding]; other site 226186000802 membrane-bound complex binding site; other site 226186000803 hinge residues; other site 226186000804 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 226186000805 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 226186000806 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 226186000807 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 226186000808 TPP-binding site [chemical binding]; other site 226186000809 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226186000810 dimer interface [polypeptide binding]; other site 226186000811 substrate binding site [chemical binding]; other site 226186000812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226186000813 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 226186000814 Ferredoxin [Energy production and conversion]; Region: COG1146 226186000815 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186000816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186000817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186000818 Tetratricopeptide repeat; Region: TPR_1; pfam00515 226186000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186000820 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226186000821 Walker A motif; other site 226186000822 ATP binding site [chemical binding]; other site 226186000823 Walker B motif; other site 226186000824 arginine finger; other site 226186000825 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226186000826 metal ion-dependent adhesion site (MIDAS); other site 226186000827 Protein of unknown function (DUF456); Region: DUF456; pfam04306 226186000828 Right handed beta helix region; Region: Beta_helix; pfam13229 226186000829 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186000830 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186000831 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 226186000832 active site 226186000833 homotrimer interface [polypeptide binding]; other site 226186000834 catalytic site [active] 226186000835 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 226186000836 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 226186000837 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 226186000838 B12 binding site [chemical binding]; other site 226186000839 cobalt ligand [ion binding]; other site 226186000840 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 226186000841 Na binding site [ion binding]; other site 226186000842 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 226186000843 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 226186000844 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 226186000845 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 226186000846 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 226186000847 TPP-binding site [chemical binding]; other site 226186000848 dimer interface [polypeptide binding]; other site 226186000849 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226186000850 PYR/PP interface [polypeptide binding]; other site 226186000851 dimer interface [polypeptide binding]; other site 226186000852 TPP binding site [chemical binding]; other site 226186000853 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226186000854 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 226186000855 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 226186000856 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186000857 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 226186000858 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 226186000859 putative N- and C-terminal domain interface [polypeptide binding]; other site 226186000860 putative active site [active] 226186000861 MgATP binding site [chemical binding]; other site 226186000862 catalytic site [active] 226186000863 metal binding site [ion binding]; metal-binding site 226186000864 putative carbohydrate binding site [chemical binding]; other site 226186000865 L-arabinose isomerase; Provisional; Region: PRK02929 226186000866 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 226186000867 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186000868 trimer interface [polypeptide binding]; other site 226186000869 putative substrate binding site [chemical binding]; other site 226186000870 putative metal binding site [ion binding]; other site 226186000871 hypothetical protein; Reviewed; Region: PRK12275 226186000872 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 226186000873 intersubunit interface [polypeptide binding]; other site 226186000874 active site 226186000875 Zn2+ binding site [ion binding]; other site 226186000876 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 226186000877 nudix motif; other site 226186000878 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 226186000879 Na binding site [ion binding]; other site 226186000880 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226186000881 active site 226186000882 catalytic residues [active] 226186000883 putative transposase OrfB; Reviewed; Region: PHA02517 226186000884 Integrase core domain; Region: rve; pfam00665 226186000885 Integrase core domain; Region: rve_3; pfam13683 226186000886 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 226186000887 substrate binding site [chemical binding]; other site 226186000888 active site 226186000889 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186000890 SusD family; Region: SusD; pfam07980 226186000891 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000892 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000893 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186000894 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186000895 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186000896 SusD family; Region: SusD; pfam07980 226186000897 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186000898 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186000899 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186000900 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186000901 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186000902 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186000903 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186000904 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186000905 Two component regulator propeller; Region: Reg_prop; pfam07494 226186000906 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186000907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186000908 SlyX; Region: SlyX; cl01090 226186000909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186000910 dimer interface [polypeptide binding]; other site 226186000911 phosphorylation site [posttranslational modification] 226186000912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186000913 ATP binding site [chemical binding]; other site 226186000914 Mg2+ binding site [ion binding]; other site 226186000915 G-X-G motif; other site 226186000916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186000917 active site 226186000918 phosphorylation site [posttranslational modification] 226186000919 intermolecular recognition site; other site 226186000920 dimerization interface [polypeptide binding]; other site 226186000921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186000922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186000923 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 226186000924 substrate binding site [chemical binding]; other site 226186000925 active site 226186000926 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 226186000927 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 226186000928 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 226186000929 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 226186000930 substrate binding site [chemical binding]; other site 226186000931 active site 226186000932 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 226186000933 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 226186000934 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226186000935 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226186000936 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186000937 L-fucose transporter; Provisional; Region: PRK10133; cl17665 226186000938 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226186000939 active site 226186000940 catalytic residues [active] 226186000941 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 226186000942 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 226186000943 ligand binding site [chemical binding]; other site 226186000944 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186000945 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186000946 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186000947 active site 226186000948 catalytic residues [active] 226186000949 DNA binding site [nucleotide binding] 226186000950 Int/Topo IB signature motif; other site 226186000951 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186000952 transcriptional activator RfaH; Region: RfaH; TIGR01955 226186000953 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 226186000954 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 226186000955 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 226186000956 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226186000957 NAD(P) binding site [chemical binding]; other site 226186000958 homodimer interface [polypeptide binding]; other site 226186000959 substrate binding site [chemical binding]; other site 226186000960 active site 226186000961 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 226186000962 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 226186000963 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186000964 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186000965 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186000966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186000967 NAD(P) binding site [chemical binding]; other site 226186000968 active site 226186000969 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 226186000970 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226186000971 NAD(P) binding site [chemical binding]; other site 226186000972 homodimer interface [polypeptide binding]; other site 226186000973 substrate binding site [chemical binding]; other site 226186000974 active site 226186000975 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 226186000976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186000977 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226186000978 NAD(P) binding site [chemical binding]; other site 226186000979 active site 226186000980 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 226186000981 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 226186000982 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226186000983 active site 226186000984 homodimer interface [polypeptide binding]; other site 226186000985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186000986 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 226186000987 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186000988 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 226186000989 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 226186000990 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 226186000991 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186000992 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226186000993 trimer interface [polypeptide binding]; other site 226186000994 active site 226186000995 CoA binding site [chemical binding]; other site 226186000996 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186000997 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226186000998 trimer interface [polypeptide binding]; other site 226186000999 active site 226186001000 substrate binding site [chemical binding]; other site 226186001001 CoA binding site [chemical binding]; other site 226186001002 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186001003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001004 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 226186001005 putative ADP-binding pocket [chemical binding]; other site 226186001006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186001008 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226186001009 trimer interface [polypeptide binding]; other site 226186001010 active site 226186001011 substrate binding site [chemical binding]; other site 226186001012 CoA binding site [chemical binding]; other site 226186001013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001014 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 226186001015 putative ADP-binding pocket [chemical binding]; other site 226186001016 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 226186001017 Mg++ binding site [ion binding]; other site 226186001018 putative catalytic motif [active] 226186001019 putative substrate binding site [chemical binding]; other site 226186001020 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 226186001021 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186001022 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 226186001023 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 226186001024 Chain length determinant protein; Region: Wzz; pfam02706 226186001025 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226186001026 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226186001027 AAA domain; Region: AAA_31; pfam13614 226186001028 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186001029 VirE N-terminal domain; Region: VirE_N; pfam08800 226186001030 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 226186001031 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186001032 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 226186001033 YtxH-like protein; Region: YtxH; pfam12732 226186001034 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 226186001035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186001036 NAD(P) binding site [chemical binding]; other site 226186001037 active site 226186001038 Sporulation related domain; Region: SPOR; pfam05036 226186001039 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 226186001040 active site 226186001041 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 226186001042 transmembrane helices; other site 226186001043 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 226186001044 TrkA-C domain; Region: TrkA_C; pfam02080 226186001045 AAA domain; Region: AAA_33; pfam13671 226186001046 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 226186001047 ligand-binding site [chemical binding]; other site 226186001048 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 226186001049 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226186001050 Active Sites [active] 226186001051 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 226186001052 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 226186001053 CysD dimerization site [polypeptide binding]; other site 226186001054 G1 box; other site 226186001055 putative GEF interaction site [polypeptide binding]; other site 226186001056 GTP/Mg2+ binding site [chemical binding]; other site 226186001057 Switch I region; other site 226186001058 G2 box; other site 226186001059 G3 box; other site 226186001060 Switch II region; other site 226186001061 G4 box; other site 226186001062 G5 box; other site 226186001063 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 226186001064 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 226186001065 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 226186001066 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186001067 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186001068 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186001069 ligand binding site [chemical binding]; other site 226186001070 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 226186001071 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226186001072 active site 226186001073 catalytic residues [active] 226186001074 metal binding site [ion binding]; metal-binding site 226186001075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001076 TPR motif; other site 226186001077 TPR repeat; Region: TPR_11; pfam13414 226186001078 binding surface 226186001079 TPR repeat; Region: TPR_11; pfam13414 226186001080 TPR repeat; Region: TPR_11; pfam13414 226186001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001082 TPR motif; other site 226186001083 binding surface 226186001084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001085 binding surface 226186001086 TPR repeat; Region: TPR_11; pfam13414 226186001087 TPR motif; other site 226186001088 TPR repeat; Region: TPR_11; pfam13414 226186001089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001090 binding surface 226186001091 TPR motif; other site 226186001092 TPR repeat; Region: TPR_11; pfam13414 226186001093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001094 TPR motif; other site 226186001095 TPR repeat; Region: TPR_11; pfam13414 226186001096 binding surface 226186001097 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 226186001098 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226186001099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226186001100 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226186001101 active site 226186001102 dimer interface [polypeptide binding]; other site 226186001103 motif 1; other site 226186001104 motif 2; other site 226186001105 motif 3; other site 226186001106 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226186001107 anticodon binding site; other site 226186001108 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 226186001109 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 226186001110 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 226186001111 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 226186001112 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 226186001113 23S rRNA binding site [nucleotide binding]; other site 226186001114 L21 binding site [polypeptide binding]; other site 226186001115 L13 binding site [polypeptide binding]; other site 226186001116 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226186001117 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226186001118 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 226186001119 Ferredoxin [Energy production and conversion]; Region: COG1146 226186001120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186001121 active site 226186001122 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 226186001123 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 226186001124 active site 226186001125 AMP binding site [chemical binding]; other site 226186001126 homodimer interface [polypeptide binding]; other site 226186001127 acyl-activating enzyme (AAE) consensus motif; other site 226186001128 CoA binding site [chemical binding]; other site 226186001129 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 226186001130 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226186001131 dimer interface [polypeptide binding]; other site 226186001132 PYR/PP interface [polypeptide binding]; other site 226186001133 TPP binding site [chemical binding]; other site 226186001134 substrate binding site [chemical binding]; other site 226186001135 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 226186001136 TPP-binding site; other site 226186001137 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 226186001138 dimerization interface [polypeptide binding]; other site 226186001139 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 226186001140 active site 226186001141 substrate binding site [chemical binding]; other site 226186001142 Mg2+ binding site [ion binding]; other site 226186001143 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 226186001144 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186001145 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 226186001146 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 226186001147 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 226186001148 Domain of unknown function (DUF4434); Region: DUF4434; pfam14488 226186001149 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 226186001150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186001151 putative substrate translocation pore; other site 226186001152 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 226186001153 dimerization interface [polypeptide binding]; other site 226186001154 putative active cleft [active] 226186001155 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 226186001156 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 226186001157 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 226186001158 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186001159 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186001160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186001161 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186001162 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186001163 SusD family; Region: SusD; pfam07980 226186001164 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186001165 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186001166 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186001167 sugar binding site [chemical binding]; other site 226186001168 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186001169 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 226186001170 putative active site [active] 226186001171 catalytic site [active] 226186001172 putative metal binding site [ion binding]; other site 226186001173 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186001174 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 226186001175 active site 226186001176 catalytic triad [active] 226186001177 oxyanion hole [active] 226186001178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 226186001179 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186001180 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226186001181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226186001182 active site 226186001183 metal binding site [ion binding]; metal-binding site 226186001184 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186001185 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226186001186 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186001187 SusD family; Region: SusD; pfam07980 226186001188 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186001189 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186001190 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186001191 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186001192 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186001193 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 226186001194 dimerization interface [polypeptide binding]; other site 226186001195 putative active cleft [active] 226186001196 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 226186001197 N-terminal domain of BNR-repeat neuraminidase; Region: BNR_assoc_N; pfam14873 226186001198 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 226186001199 catalytic site [active] 226186001200 BNR repeat-like domain; Region: BNR_2; pfam13088 226186001201 Asp-box motif; other site 226186001202 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186001203 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cd02742 226186001204 active site 226186001205 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 226186001206 active site 226186001207 catalytic triad [active] 226186001208 oxyanion hole [active] 226186001209 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186001210 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 226186001211 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186001212 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186001213 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186001214 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 226186001215 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186001216 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186001217 active site 226186001218 Fn3 associated; Region: Fn3_assoc; pfam13287 226186001219 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186001220 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186001221 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186001222 active site 226186001223 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186001224 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186001225 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186001226 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186001227 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186001228 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186001229 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 226186001230 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 226186001231 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 226186001232 substrate binding site; other site 226186001233 tetramer interface; other site 226186001234 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 226186001235 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 226186001236 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226186001237 NADP binding site [chemical binding]; other site 226186001238 active site 226186001239 putative substrate binding site [chemical binding]; other site 226186001240 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 226186001241 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 226186001242 NAD binding site [chemical binding]; other site 226186001243 substrate binding site [chemical binding]; other site 226186001244 homodimer interface [polypeptide binding]; other site 226186001245 active site 226186001246 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186001247 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186001248 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186001249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186001250 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 226186001251 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 226186001252 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186001253 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 226186001254 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186001255 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226186001256 trimer interface [polypeptide binding]; other site 226186001257 active site 226186001258 substrate binding site [chemical binding]; other site 226186001259 CoA binding site [chemical binding]; other site 226186001260 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186001261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186001262 active site 226186001263 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 226186001264 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226186001265 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226186001266 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 226186001267 dimer interface [polypeptide binding]; other site 226186001268 active site 226186001269 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226186001270 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 226186001271 Substrate binding site; other site 226186001272 Mg++ binding site; other site 226186001273 metal-binding site 226186001274 Mg++ binding site; other site 226186001275 metal-binding site 226186001276 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 226186001277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186001278 active site 226186001279 motif I; other site 226186001280 motif II; other site 226186001281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186001282 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 226186001283 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 226186001284 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226186001285 Probable Catalytic site; other site 226186001286 metal-binding site 226186001287 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 226186001288 CoA-binding domain; Region: CoA_binding_3; pfam13727 226186001289 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226186001290 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 226186001291 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186001292 tyrosine kinase; Provisional; Region: PRK11519 226186001293 Chain length determinant protein; Region: Wzz; pfam02706 226186001294 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226186001295 AAA domain; Region: AAA_31; pfam13614 226186001296 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186001297 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186001298 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186001299 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186001300 SusD family; Region: SusD; pfam07980 226186001301 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186001302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186001303 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186001304 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 226186001305 galactarate dehydratase; Region: galactar-dH20; TIGR03248 226186001306 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 226186001307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226186001308 DNA binding site [nucleotide binding] 226186001309 domain linker motif; other site 226186001310 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 226186001311 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 226186001312 ligand binding site [chemical binding]; other site 226186001313 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226186001314 substrate binding site [chemical binding]; other site 226186001315 ATP binding site [chemical binding]; other site 226186001316 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 226186001317 Entner-Doudoroff aldolase; Region: eda; TIGR01182 226186001318 active site 226186001319 intersubunit interface [polypeptide binding]; other site 226186001320 catalytic residue [active] 226186001321 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 226186001322 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 226186001323 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 226186001324 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 226186001325 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 226186001326 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 226186001327 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186001328 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 226186001329 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 226186001330 N-terminal plug; other site 226186001331 ligand-binding site [chemical binding]; other site 226186001332 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 226186001333 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 226186001334 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 226186001335 putative transporter; Validated; Region: PRK03818 226186001336 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186001337 TrkA-C domain; Region: TrkA_C; pfam02080 226186001338 TrkA-C domain; Region: TrkA_C; pfam02080 226186001339 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186001340 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186001341 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186001342 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 226186001343 N-terminal plug; other site 226186001344 ligand-binding site [chemical binding]; other site 226186001345 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186001346 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 226186001347 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 226186001348 N-terminal plug; other site 226186001349 ligand-binding site [chemical binding]; other site 226186001350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 226186001351 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 226186001352 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186001353 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186001354 active site 226186001355 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 226186001356 PA14 domain; Region: PA14; pfam07691 226186001357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186001358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186001359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226186001360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226186001361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186001362 Walker A/P-loop; other site 226186001363 ATP binding site [chemical binding]; other site 226186001364 Q-loop/lid; other site 226186001365 ABC transporter signature motif; other site 226186001366 Walker B; other site 226186001367 D-loop; other site 226186001368 H-loop/switch region; other site 226186001369 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226186001370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226186001371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186001372 Walker A/P-loop; other site 226186001373 ATP binding site [chemical binding]; other site 226186001374 Q-loop/lid; other site 226186001375 ABC transporter signature motif; other site 226186001376 Walker B; other site 226186001377 D-loop; other site 226186001378 H-loop/switch region; other site 226186001379 radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133 226186001380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186001381 FeS/SAM binding site; other site 226186001382 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 226186001383 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 226186001384 TQO small subunit DoxD; Region: DoxD; pfam04173 226186001385 TQO small subunit DoxA; Region: DoxA; pfam07680 226186001386 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 226186001387 flavodoxin FldA; Validated; Region: PRK09267 226186001388 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 226186001389 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 226186001390 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 226186001391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186001392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186001393 DNA binding residues [nucleotide binding] 226186001394 dimerization interface [polypeptide binding]; other site 226186001395 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186001396 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226186001397 trimer interface [polypeptide binding]; other site 226186001398 active site 226186001399 substrate binding site [chemical binding]; other site 226186001400 CoA binding site [chemical binding]; other site 226186001401 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 226186001402 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226186001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186001404 active site 226186001405 phosphorylation site [posttranslational modification] 226186001406 intermolecular recognition site; other site 226186001407 dimerization interface [polypeptide binding]; other site 226186001408 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 226186001409 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 226186001410 active site 226186001411 homodimer interface [polypeptide binding]; other site 226186001412 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 226186001413 substrate binding site [chemical binding]; other site 226186001414 active site 226186001415 catalytic residues [active] 226186001416 heterodimer interface [polypeptide binding]; other site 226186001417 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 226186001418 active site 226186001419 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 226186001420 active site 226186001421 ribulose/triose binding site [chemical binding]; other site 226186001422 phosphate binding site [ion binding]; other site 226186001423 substrate (anthranilate) binding pocket [chemical binding]; other site 226186001424 product (indole) binding pocket [chemical binding]; other site 226186001425 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 226186001426 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226186001427 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226186001428 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 226186001429 Glutamine amidotransferase class-I; Region: GATase; pfam00117 226186001430 glutamine binding [chemical binding]; other site 226186001431 catalytic triad [active] 226186001432 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 226186001433 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 226186001434 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 226186001435 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 226186001436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186001437 catalytic residue [active] 226186001438 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 226186001439 dimer interface [polypeptide binding]; other site 226186001440 active site 226186001441 metal binding site [ion binding]; metal-binding site 226186001442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186001443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186001444 ATP binding site [chemical binding]; other site 226186001445 Mg2+ binding site [ion binding]; other site 226186001446 G-X-G motif; other site 226186001447 PAS domain S-box; Region: sensory_box; TIGR00229 226186001448 PAS domain; Region: PAS_9; pfam13426 226186001449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186001450 dimer interface [polypeptide binding]; other site 226186001451 phosphorylation site [posttranslational modification] 226186001452 anion transporter; Region: dass; TIGR00785 226186001453 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 226186001454 transmembrane helices; other site 226186001455 TrkA-C domain; Region: TrkA_C; pfam02080 226186001456 TrkA-C domain; Region: TrkA_C; pfam02080 226186001457 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 226186001458 transmembrane helices; other site 226186001459 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 226186001460 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 226186001461 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 226186001462 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 226186001463 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 226186001464 domain interface [polypeptide binding]; other site 226186001465 active site 226186001466 catalytic site [active] 226186001467 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 226186001468 domain interface [polypeptide binding]; other site 226186001469 active site 226186001470 catalytic site [active] 226186001471 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 226186001472 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 226186001473 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 226186001474 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 226186001475 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 226186001476 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 226186001477 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 226186001478 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 226186001479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186001480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186001481 homodimer interface [polypeptide binding]; other site 226186001482 catalytic residue [active] 226186001483 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 226186001484 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 226186001485 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 226186001486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186001487 catalytic residues [active] 226186001488 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186001489 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 226186001490 putative active site [active] 226186001491 catalytic site [active] 226186001492 putative metal binding site [ion binding]; other site 226186001493 asparagine synthetase B; Provisional; Region: asnB; PRK09431 226186001494 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226186001495 active site 226186001496 dimer interface [polypeptide binding]; other site 226186001497 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226186001498 Ligand Binding Site [chemical binding]; other site 226186001499 Molecular Tunnel; other site 226186001500 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 226186001501 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 226186001502 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 226186001503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226186001504 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 226186001505 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 226186001506 active site 226186001507 dimer interface [polypeptide binding]; other site 226186001508 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 226186001509 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 226186001510 active site 226186001511 FMN binding site [chemical binding]; other site 226186001512 substrate binding site [chemical binding]; other site 226186001513 3Fe-4S cluster binding site [ion binding]; other site 226186001514 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 226186001515 domain interface; other site 226186001516 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 226186001517 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 226186001518 glutaminase active site [active] 226186001519 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226186001520 dimer interface [polypeptide binding]; other site 226186001521 active site 226186001522 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226186001523 dimer interface [polypeptide binding]; other site 226186001524 active site 226186001525 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 226186001526 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 226186001527 active site 226186001528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186001529 active site 226186001530 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 226186001531 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 226186001532 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 226186001533 catalytic site [active] 226186001534 subunit interface [polypeptide binding]; other site 226186001535 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 226186001536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186001537 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226186001538 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 226186001539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186001540 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186001541 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 226186001542 probable substrate binding site [chemical binding]; other site 226186001543 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 226186001544 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 226186001545 Substrate binding site; other site 226186001546 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186001547 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186001548 Outer membrane efflux protein; Region: OEP; pfam02321 226186001549 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186001550 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 226186001551 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186001552 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 226186001553 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226186001554 Walker A/P-loop; other site 226186001555 ATP binding site [chemical binding]; other site 226186001556 Q-loop/lid; other site 226186001557 ABC transporter signature motif; other site 226186001558 Walker B; other site 226186001559 D-loop; other site 226186001560 H-loop/switch region; other site 226186001561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186001562 Walker A/P-loop; other site 226186001563 ATP binding site [chemical binding]; other site 226186001564 Q-loop/lid; other site 226186001565 ABC transporter signature motif; other site 226186001566 Walker B; other site 226186001567 D-loop; other site 226186001568 H-loop/switch region; other site 226186001569 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226186001570 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 226186001571 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 226186001572 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 226186001573 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226186001574 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 226186001575 putative dimer interface [polypeptide binding]; other site 226186001576 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226186001577 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226186001578 putative active site [active] 226186001579 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 226186001580 active site 226186001581 catalytic triad [active] 226186001582 oxyanion hole [active] 226186001583 excinuclease ABC subunit B; Provisional; Region: PRK05298 226186001584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186001585 ATP binding site [chemical binding]; other site 226186001586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186001587 nucleotide binding region [chemical binding]; other site 226186001588 ATP-binding site [chemical binding]; other site 226186001589 Ultra-violet resistance protein B; Region: UvrB; pfam12344 226186001590 UvrB/uvrC motif; Region: UVR; pfam02151 226186001591 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 226186001592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226186001593 acyl-activating enzyme (AAE) consensus motif; other site 226186001594 AMP binding site [chemical binding]; other site 226186001595 active site 226186001596 CoA binding site [chemical binding]; other site 226186001597 ACT domain-containing protein [General function prediction only]; Region: COG4747 226186001598 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 226186001599 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 226186001600 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 226186001601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226186001602 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 226186001603 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186001604 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226186001605 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186001606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186001607 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226186001608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186001609 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 226186001610 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226186001611 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226186001612 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 226186001613 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 226186001614 putative deacylase active site [active] 226186001615 POT family; Region: PTR2; cl17359 226186001616 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226186001617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186001618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186001619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186001620 Coenzyme A binding pocket [chemical binding]; other site 226186001621 Predicted transcriptional regulators [Transcription]; Region: COG1695 226186001622 putative Zn2+ binding site [ion binding]; other site 226186001623 putative DNA binding site [nucleotide binding]; other site 226186001624 PspC domain; Region: PspC; pfam04024 226186001625 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 226186001626 Flavin Reductases; Region: FlaRed; cl00801 226186001627 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 226186001628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186001629 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186001630 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186001631 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186001632 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 226186001633 membrane protein insertase; Provisional; Region: PRK01318 226186001634 YidC periplasmic domain; Region: YidC_periplas; pfam14849 226186001635 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 226186001636 CTP synthetase; Validated; Region: pyrG; PRK05380 226186001637 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 226186001638 Catalytic site [active] 226186001639 active site 226186001640 UTP binding site [chemical binding]; other site 226186001641 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 226186001642 active site 226186001643 putative oxyanion hole; other site 226186001644 catalytic triad [active] 226186001645 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 226186001646 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186001647 Domain of unknown function, B. Theta Gene description (DUF4119); Region: DUF4119; pfam13494 226186001648 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186001649 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 226186001650 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186001651 active site 226186001652 catalytic residues [active] 226186001653 DNA binding site [nucleotide binding] 226186001654 Int/Topo IB signature motif; other site 226186001655 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186001656 transcriptional activator RfaH; Region: RfaH; TIGR01955 226186001657 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 226186001658 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 226186001659 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 226186001660 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226186001661 NAD(P) binding site [chemical binding]; other site 226186001662 homodimer interface [polypeptide binding]; other site 226186001663 substrate binding site [chemical binding]; other site 226186001664 active site 226186001665 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 226186001666 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 226186001667 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186001668 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186001669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186001670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186001671 NAD(P) binding site [chemical binding]; other site 226186001672 active site 226186001673 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 226186001674 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226186001675 active site 226186001676 homodimer interface [polypeptide binding]; other site 226186001677 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 226186001678 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 226186001679 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186001680 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186001681 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 226186001682 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186001683 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186001684 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 226186001685 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 226186001686 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186001687 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186001688 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 226186001689 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226186001690 putative trimer interface [polypeptide binding]; other site 226186001691 putative CoA binding site [chemical binding]; other site 226186001692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186001693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001695 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186001696 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186001697 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 226186001698 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226186001699 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226186001700 inhibitor-cofactor binding pocket; inhibition site 226186001701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186001702 catalytic residue [active] 226186001703 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 226186001704 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186001705 tyrosine kinase; Provisional; Region: PRK11519 226186001706 Chain length determinant protein; Region: Wzz; pfam02706 226186001707 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226186001708 AAA domain; Region: AAA_31; pfam13614 226186001709 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186001710 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 226186001711 ferredoxin; Validated; Region: PRK07118 226186001712 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186001713 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 226186001714 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 226186001715 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 226186001716 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 226186001717 SLBB domain; Region: SLBB; pfam10531 226186001718 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 226186001719 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 226186001720 FMN-binding domain; Region: FMN_bind; cl01081 226186001721 electron transport complex RsxE subunit; Provisional; Region: PRK12405 226186001722 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 226186001723 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 226186001724 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226186001725 NAD binding site [chemical binding]; other site 226186001726 homodimer interface [polypeptide binding]; other site 226186001727 active site 226186001728 substrate binding site [chemical binding]; other site 226186001729 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 226186001730 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226186001731 replicative DNA helicase; Region: DnaB; TIGR00665 226186001732 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 226186001733 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 226186001734 Walker A motif; other site 226186001735 ATP binding site [chemical binding]; other site 226186001736 Walker B motif; other site 226186001737 DNA binding loops [nucleotide binding] 226186001738 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 226186001739 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226186001740 putative tRNA-binding site [nucleotide binding]; other site 226186001741 B3/4 domain; Region: B3_4; pfam03483 226186001742 tRNA synthetase B5 domain; Region: B5; smart00874 226186001743 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 226186001744 dimer interface [polypeptide binding]; other site 226186001745 motif 1; other site 226186001746 motif 3; other site 226186001747 motif 2; other site 226186001748 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 226186001749 hypothetical protein; Provisional; Region: PRK12378 226186001750 TSCPD domain; Region: TSCPD; cl14834 226186001751 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 226186001752 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 226186001753 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 226186001754 putative active site [active] 226186001755 putative catalytic site [active] 226186001756 putative DNA binding site [nucleotide binding]; other site 226186001757 putative phosphate binding site [ion binding]; other site 226186001758 metal binding site A [ion binding]; metal-binding site 226186001759 putative AP binding site [nucleotide binding]; other site 226186001760 putative metal binding site B [ion binding]; other site 226186001761 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 226186001762 GTP-binding protein LepA; Provisional; Region: PRK05433 226186001763 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 226186001764 G1 box; other site 226186001765 putative GEF interaction site [polypeptide binding]; other site 226186001766 GTP/Mg2+ binding site [chemical binding]; other site 226186001767 Switch I region; other site 226186001768 G2 box; other site 226186001769 G3 box; other site 226186001770 Switch II region; other site 226186001771 G4 box; other site 226186001772 G5 box; other site 226186001773 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 226186001774 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226186001775 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 226186001776 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 226186001777 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 226186001778 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226186001779 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186001780 STAT protein, all-alpha domain; Region: STAT_alpha; pfam01017 226186001781 RmuC family; Region: RmuC; pfam02646 226186001782 methionine aminopeptidase; Provisional; Region: PRK12318 226186001783 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226186001784 active site 226186001785 B12 binding domain; Region: B12-binding; pfam02310 226186001786 B12 binding site [chemical binding]; other site 226186001787 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 226186001788 Radical SAM superfamily; Region: Radical_SAM; pfam04055 226186001789 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 226186001790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226186001791 RNA binding surface [nucleotide binding]; other site 226186001792 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226186001793 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226186001794 active site 226186001795 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 226186001796 TRAM domain; Region: TRAM; cl01282 226186001797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186001798 S-adenosylmethionine binding site [chemical binding]; other site 226186001799 pyruvate phosphate dikinase; Provisional; Region: PRK09279 226186001800 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 226186001801 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 226186001802 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 226186001803 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186001804 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186001805 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226186001806 thiamine phosphate binding site [chemical binding]; other site 226186001807 active site 226186001808 pyrophosphate binding site [ion binding]; other site 226186001809 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 226186001810 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226186001811 ATP binding site [chemical binding]; other site 226186001812 substrate interface [chemical binding]; other site 226186001813 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 226186001814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186001815 FeS/SAM binding site; other site 226186001816 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 226186001817 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 226186001818 ThiC-associated domain; Region: ThiC-associated; pfam13667 226186001819 ThiC family; Region: ThiC; pfam01964 226186001820 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 226186001821 ThiS interaction site; other site 226186001822 putative active site [active] 226186001823 tetramer interface [polypeptide binding]; other site 226186001824 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226186001825 thiamine phosphate binding site [chemical binding]; other site 226186001826 active site 226186001827 pyrophosphate binding site [ion binding]; other site 226186001828 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 226186001829 thiS-thiF/thiG interaction site; other site 226186001830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186001831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186001832 dimer interface [polypeptide binding]; other site 226186001833 phosphorylation site [posttranslational modification] 226186001834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186001835 ATP binding site [chemical binding]; other site 226186001836 Mg2+ binding site [ion binding]; other site 226186001837 G-X-G motif; other site 226186001838 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226186001839 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226186001840 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226186001841 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 226186001842 VirE3; Region: VirE3; pfam06661 226186001843 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 226186001844 Part of AAA domain; Region: AAA_19; pfam13245 226186001845 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226186001846 Conjugal transfer protein TrbH; Region: TrbH; cl19428 226186001847 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 226186001848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226186001849 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226186001850 O-Antigen ligase; Region: Wzy_C; pfam04932 226186001851 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 226186001852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186001853 binding surface 226186001854 TPR motif; other site 226186001855 NVEALA protein; Region: NVEALA; pfam14055 226186001856 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226186001857 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226186001858 Catalytic site [active] 226186001859 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186001860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186001861 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186001862 OB-fold nucleic acid binding domain; Region: tRNA_anti-codon; pfam01336 226186001863 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186001864 MMPL family; Region: MMPL; cl14618 226186001865 MMPL family; Region: MMPL; cl14618 226186001866 Outer membrane efflux protein; Region: OEP; pfam02321 226186001867 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186001868 Outer membrane efflux protein; Region: OEP; pfam02321 226186001869 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186001870 MMPL family; Region: MMPL; cl14618 226186001871 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 226186001872 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 226186001873 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 226186001874 dimer interface [polypeptide binding]; other site 226186001875 active site 226186001876 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226186001877 catalytic residues [active] 226186001878 substrate binding site [chemical binding]; other site 226186001879 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226186001880 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226186001881 active site 226186001882 dimer interface [polypeptide binding]; other site 226186001883 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226186001884 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226186001885 active site 226186001886 dimer interface [polypeptide binding]; other site 226186001887 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186001888 catalytic residues [active] 226186001889 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186001890 Outer membrane efflux protein; Region: OEP; pfam02321 226186001891 Outer membrane efflux protein; Region: OEP; pfam02321 226186001892 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186001893 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 226186001894 Outer membrane efflux protein; Region: OEP; pfam02321 226186001895 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186001896 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 226186001897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186001898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226186001899 dimerization interface [polypeptide binding]; other site 226186001900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186001901 dimer interface [polypeptide binding]; other site 226186001902 phosphorylation site [posttranslational modification] 226186001903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186001904 ATP binding site [chemical binding]; other site 226186001905 Mg2+ binding site [ion binding]; other site 226186001906 G-X-G motif; other site 226186001907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186001908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186001909 active site 226186001910 phosphorylation site [posttranslational modification] 226186001911 intermolecular recognition site; other site 226186001912 dimerization interface [polypeptide binding]; other site 226186001913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186001914 DNA binding site [nucleotide binding] 226186001915 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186001916 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186001917 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186001918 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 226186001919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226186001920 acyl-activating enzyme (AAE) consensus motif; other site 226186001921 AMP binding site [chemical binding]; other site 226186001922 active site 226186001923 CoA binding site [chemical binding]; other site 226186001924 potassium/proton antiporter; Reviewed; Region: PRK05326 226186001925 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 226186001926 TrkA-C domain; Region: TrkA_C; pfam02080 226186001927 uracil-xanthine permease; Region: ncs2; TIGR00801 226186001928 Sulfate transporter family; Region: Sulfate_transp; cl19250 226186001929 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 226186001930 cubane metal cluster [ion binding]; other site 226186001931 hybrid metal cluster; other site 226186001932 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186001933 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186001934 ligand binding site [chemical binding]; other site 226186001935 flexible hinge region; other site 226186001936 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226186001937 putative switch regulator; other site 226186001938 non-specific DNA interactions [nucleotide binding]; other site 226186001939 DNA binding site [nucleotide binding] 226186001940 sequence specific DNA binding site [nucleotide binding]; other site 226186001941 putative cAMP binding site [chemical binding]; other site 226186001942 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226186001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186001944 ATP binding site [chemical binding]; other site 226186001945 Mg2+ binding site [ion binding]; other site 226186001946 G-X-G motif; other site 226186001947 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186001949 active site 226186001950 phosphorylation site [posttranslational modification] 226186001951 intermolecular recognition site; other site 226186001952 dimerization interface [polypeptide binding]; other site 226186001953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186001954 Walker A motif; other site 226186001955 ATP binding site [chemical binding]; other site 226186001956 Walker B motif; other site 226186001957 arginine finger; other site 226186001958 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186001959 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186001960 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226186001961 active site 226186001962 metal binding site [ion binding]; metal-binding site 226186001963 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186001964 FtsX-like permease family; Region: FtsX; pfam02687 226186001965 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186001966 FtsX-like permease family; Region: FtsX; pfam02687 226186001967 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186001968 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186001969 Walker A/P-loop; other site 226186001970 ATP binding site [chemical binding]; other site 226186001971 Q-loop/lid; other site 226186001972 ABC transporter signature motif; other site 226186001973 Walker B; other site 226186001974 D-loop; other site 226186001975 H-loop/switch region; other site 226186001976 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 226186001977 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186001978 FtsX-like permease family; Region: FtsX; pfam02687 226186001979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186001980 FtsX-like permease family; Region: FtsX; pfam02687 226186001981 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186001982 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226186001983 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 226186001984 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186001985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186001986 motif II; other site 226186001987 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 226186001988 oligomerization interface [polypeptide binding]; other site 226186001989 active site 226186001990 metal binding site [ion binding]; metal-binding site 226186001991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186001992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186001993 putative substrate translocation pore; other site 226186001994 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226186001995 HD domain; Region: HD_4; pfam13328 226186001996 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226186001997 synthetase active site [active] 226186001998 NTP binding site [chemical binding]; other site 226186001999 metal binding site [ion binding]; metal-binding site 226186002000 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 226186002001 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 226186002002 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 226186002003 Chloramphenicol acetyltransferase; Region: CAT; smart01059 226186002004 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 226186002005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186002006 ATP-grasp domain; Region: ATP-grasp; pfam02222 226186002007 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186002008 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186002009 substrate binding site [chemical binding]; other site 226186002010 amidase catalytic site [active] 226186002011 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186002012 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186002013 VirE N-terminal domain; Region: VirE_N; pfam08800 226186002014 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 226186002015 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186002016 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 226186002017 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226186002018 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 226186002019 alpha subunit interaction interface [polypeptide binding]; other site 226186002020 Walker A motif; other site 226186002021 ATP binding site [chemical binding]; other site 226186002022 Walker B motif; other site 226186002023 inhibitor binding site; inhibition site 226186002024 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226186002025 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 226186002026 gamma subunit interface [polypeptide binding]; other site 226186002027 LBP interface [polypeptide binding]; other site 226186002028 ATP synthase A chain; Region: ATP-synt_A; cl00413 226186002029 ATP synthase subunit C; Region: ATP-synt_C; cl00466 226186002030 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 226186002031 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 226186002032 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 226186002033 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 226186002034 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226186002035 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 226186002036 beta subunit interaction interface [polypeptide binding]; other site 226186002037 Walker A motif; other site 226186002038 ATP binding site [chemical binding]; other site 226186002039 Walker B motif; other site 226186002040 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226186002041 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 226186002042 core domain interface [polypeptide binding]; other site 226186002043 delta subunit interface [polypeptide binding]; other site 226186002044 epsilon subunit interface [polypeptide binding]; other site 226186002045 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 226186002046 PIF1-like helicase; Region: PIF1; pfam05970 226186002047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002048 Walker A motif; other site 226186002049 ATP binding site [chemical binding]; other site 226186002050 Walker B motif; other site 226186002051 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226186002052 HRDC domain; Region: HRDC; pfam00570 226186002053 Helix-turn-helix domain; Region: HTH_40; pfam14493 226186002054 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 226186002055 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 226186002056 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226186002057 NADP binding site [chemical binding]; other site 226186002058 active site 226186002059 putative substrate binding site [chemical binding]; other site 226186002060 Uncharacterized conserved protein [Function unknown]; Region: RtcB; cl17455 226186002061 Clostripain family; Region: Peptidase_C11; pfam03415 226186002062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186002063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186002064 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186002065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186002066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186002067 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 226186002068 putative NAD(P) binding site [chemical binding]; other site 226186002069 active site 226186002070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186002071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002072 active site 226186002073 phosphorylation site [posttranslational modification] 226186002074 intermolecular recognition site; other site 226186002075 dimerization interface [polypeptide binding]; other site 226186002076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186002077 DNA binding site [nucleotide binding] 226186002078 TraL protein; Region: TraL; cl06278 226186002079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002081 dimer interface [polypeptide binding]; other site 226186002082 phosphorylation site [posttranslational modification] 226186002083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002084 ATP binding site [chemical binding]; other site 226186002085 Mg2+ binding site [ion binding]; other site 226186002086 G-X-G motif; other site 226186002087 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186002088 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186002089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186002090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186002091 homodimer interface [polypeptide binding]; other site 226186002092 catalytic residue [active] 226186002093 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 226186002094 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186002095 TrkA-C domain; Region: TrkA_C; pfam02080 226186002096 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186002097 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 226186002098 Potassium binding sites [ion binding]; other site 226186002099 Cesium cation binding sites [ion binding]; other site 226186002100 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 226186002101 dimer interface [polypeptide binding]; other site 226186002102 active site 226186002103 glycine-pyridoxal phosphate binding site [chemical binding]; other site 226186002104 folate binding site [chemical binding]; other site 226186002105 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186002106 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 226186002107 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 226186002108 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 226186002109 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 226186002110 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 226186002111 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226186002112 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226186002113 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 226186002114 Transglycosylase; Region: Transgly; pfam00912 226186002115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226186002116 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 226186002117 catalytic center binding site [active] 226186002118 ATP binding site [chemical binding]; other site 226186002119 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 226186002120 Ligand binding site; other site 226186002121 oligomer interface; other site 226186002122 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186002123 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186002124 MORN repeat; Region: MORN; cl14787 226186002125 MORN repeat; Region: MORN; cl14787 226186002126 MORN repeat; Region: MORN; cl14787 226186002127 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 226186002128 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 226186002129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186002130 active site 226186002131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002133 ATP binding site [chemical binding]; other site 226186002134 Mg2+ binding site [ion binding]; other site 226186002135 G-X-G motif; other site 226186002136 GAF domain; Region: GAF_3; pfam13492 226186002137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002139 ATP binding site [chemical binding]; other site 226186002140 Mg2+ binding site [ion binding]; other site 226186002141 G-X-G motif; other site 226186002142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186002143 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 226186002144 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186002145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186002146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186002147 DNA binding residues [nucleotide binding] 226186002148 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186002149 FecR protein; Region: FecR; pfam04773 226186002150 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186002151 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002152 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186002153 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186002154 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002155 SusD family; Region: SusD; pfam07980 226186002156 arylsulfatase; Provisional; Region: PRK13759 226186002157 Sulfatase; Region: Sulfatase; pfam00884 226186002158 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002159 beta-D-glucuronidase; Provisional; Region: PRK10150 226186002160 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186002161 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186002162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186002163 Coenzyme A binding pocket [chemical binding]; other site 226186002164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002166 active site 226186002167 phosphorylation site [posttranslational modification] 226186002168 intermolecular recognition site; other site 226186002169 dimerization interface [polypeptide binding]; other site 226186002170 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186002171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186002172 ABC transporter signature motif; other site 226186002173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186002174 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226186002175 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 226186002176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186002177 binding surface 226186002178 TPR motif; other site 226186002179 para-aminobenzoate synthase component I; Validated; Region: PRK07093 226186002180 hypothetical protein; Provisional; Region: PRK07101 226186002181 substrate-cofactor binding pocket; other site 226186002182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186002183 homodimer interface [polypeptide binding]; other site 226186002184 catalytic residue [active] 226186002185 TIGR02453 family protein; Region: TIGR02453 226186002186 Domain of unknown function (DUF386); Region: DUF386; cl01047 226186002187 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 226186002188 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 226186002189 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 226186002190 active site 226186002191 catalytic site [active] 226186002192 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 226186002193 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002194 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 226186002195 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 226186002196 active site 226186002197 catalytic site [active] 226186002198 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226186002199 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 226186002200 active site 226186002201 nucleophile elbow; other site 226186002202 4Fe-4S binding domain; Region: Fer4_5; pfam12801 226186002203 4Fe-4S binding domain; Region: Fer4_5; pfam12801 226186002204 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186002205 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186002206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186002207 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 226186002208 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186002209 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186002210 Domain of unknown function (DUF362); Region: DUF362; pfam04015 226186002211 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 226186002212 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226186002214 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226186002215 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 226186002216 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 226186002217 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 226186002218 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 226186002219 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 226186002220 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 226186002221 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 226186002222 CoA binding domain; Region: CoA_binding; pfam02629 226186002223 CoA-ligase; Region: Ligase_CoA; pfam00549 226186002224 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 226186002225 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 226186002226 CoA-ligase; Region: Ligase_CoA; pfam00549 226186002227 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 226186002228 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226186002229 dimer interface [polypeptide binding]; other site 226186002230 substrate binding site [chemical binding]; other site 226186002231 ATP binding site [chemical binding]; other site 226186002232 NUDIX domain; Region: NUDIX; pfam00293 226186002233 nudix motif; other site 226186002234 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 226186002235 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 226186002236 D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810 226186002237 putative N- and C-terminal domain interface [polypeptide binding]; other site 226186002238 putative active site [active] 226186002239 putative MgATP binding site [chemical binding]; other site 226186002240 catalytic site [active] 226186002241 metal binding site [ion binding]; metal-binding site 226186002242 putative xylulose binding site [chemical binding]; other site 226186002243 putative homodimer interface [polypeptide binding]; other site 226186002244 xylose isomerase; Provisional; Region: PRK05474 226186002245 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 226186002246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186002247 putative substrate translocation pore; other site 226186002248 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186002249 Virulence-associated protein E; Region: VirE; pfam05272 226186002250 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186002251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226186002252 putative DNA binding site [nucleotide binding]; other site 226186002253 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186002254 putative Zn2+ binding site [ion binding]; other site 226186002255 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 226186002256 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 226186002257 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 226186002258 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 226186002259 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 226186002260 P loop; other site 226186002261 Nucleotide binding site [chemical binding]; other site 226186002262 DTAP/Switch II; other site 226186002263 Switch I; other site 226186002264 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 226186002265 P loop; other site 226186002266 Nucleotide binding site [chemical binding]; other site 226186002267 DTAP/Switch II; other site 226186002268 Switch I; other site 226186002269 Sodium Bile acid symporter family; Region: SBF; cl19217 226186002270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186002271 Coenzyme A binding pocket [chemical binding]; other site 226186002272 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 226186002273 putative active site [active] 226186002274 catalytic triad [active] 226186002275 putative dimer interface [polypeptide binding]; other site 226186002276 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 226186002277 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 226186002278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226186002279 active site 226186002280 HIGH motif; other site 226186002281 nucleotide binding site [chemical binding]; other site 226186002282 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226186002283 active site 226186002284 KMSKS motif; other site 226186002285 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 226186002286 tRNA binding surface [nucleotide binding]; other site 226186002287 anticodon binding site; other site 226186002288 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 226186002289 lipoprotein signal peptidase; Provisional; Region: PRK14788 226186002290 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 226186002291 YtxH-like protein; Region: YtxH; cl02079 226186002292 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226186002293 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226186002294 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226186002295 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186002296 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186002297 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186002298 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 226186002299 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186002300 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 226186002301 DoxX; Region: DoxX; pfam07681 226186002302 NlpE N-terminal domain; Region: NlpE; cl19736 226186002303 PAS domain; Region: PAS_9; pfam13426 226186002304 PAS fold; Region: PAS_3; pfam08447 226186002305 PAS fold; Region: PAS_3; pfam08447 226186002306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002307 dimer interface [polypeptide binding]; other site 226186002308 phosphorylation site [posttranslational modification] 226186002309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002310 ATP binding site [chemical binding]; other site 226186002311 Mg2+ binding site [ion binding]; other site 226186002312 G-X-G motif; other site 226186002313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002314 active site 226186002315 phosphorylation site [posttranslational modification] 226186002316 intermolecular recognition site; other site 226186002317 dimerization interface [polypeptide binding]; other site 226186002318 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 226186002319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186002320 motif I; other site 226186002321 active site 226186002322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186002323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186002324 putative substrate translocation pore; other site 226186002325 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 226186002326 glucuronate isomerase; Reviewed; Region: PRK02925 226186002327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226186002328 DNA binding site [nucleotide binding] 226186002329 domain linker motif; other site 226186002330 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 226186002331 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 226186002332 ligand binding site [chemical binding]; other site 226186002333 altronate oxidoreductase; Provisional; Region: PRK03643 226186002334 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 226186002335 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 226186002336 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 226186002337 Zn binding site [ion binding]; other site 226186002338 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186002339 phosphopeptide binding site; other site 226186002340 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 226186002341 Sporulation related domain; Region: SPOR; pfam05036 226186002342 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 226186002343 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 226186002344 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 226186002345 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186002346 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186002347 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 226186002348 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226186002349 ATP binding site [chemical binding]; other site 226186002350 Mg++ binding site [ion binding]; other site 226186002351 motif III; other site 226186002352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186002353 nucleotide binding region [chemical binding]; other site 226186002354 ATP-binding site [chemical binding]; other site 226186002355 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 226186002356 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 226186002357 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226186002358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186002359 motif II; other site 226186002360 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186002361 catalytic residues [active] 226186002362 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 226186002363 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 226186002364 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 226186002365 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226186002366 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 226186002367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002368 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226186002369 Walker A motif; other site 226186002370 ATP binding site [chemical binding]; other site 226186002371 Walker B motif; other site 226186002372 arginine finger; other site 226186002373 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 226186002374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186002375 S-adenosylmethionine binding site [chemical binding]; other site 226186002376 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226186002377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186002378 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186002379 DNA binding residues [nucleotide binding] 226186002380 dimerization interface [polypeptide binding]; other site 226186002381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186002382 S-adenosylmethionine binding site [chemical binding]; other site 226186002383 PAS domain; Region: PAS_8; pfam13188 226186002384 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226186002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002386 ATP binding site [chemical binding]; other site 226186002387 Mg2+ binding site [ion binding]; other site 226186002388 G-X-G motif; other site 226186002389 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186002390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002391 active site 226186002392 phosphorylation site [posttranslational modification] 226186002393 intermolecular recognition site; other site 226186002394 dimerization interface [polypeptide binding]; other site 226186002395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002396 Walker A motif; other site 226186002397 ATP binding site [chemical binding]; other site 226186002398 Walker B motif; other site 226186002399 arginine finger; other site 226186002400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186002401 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186002402 Outer membrane efflux protein; Region: OEP; pfam02321 226186002403 Outer membrane efflux protein; Region: OEP; pfam02321 226186002404 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186002405 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186002406 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002407 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 226186002408 FtsX-like permease family; Region: FtsX; pfam02687 226186002409 FtsX-like permease family; Region: FtsX; pfam02687 226186002410 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186002411 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186002412 Walker A/P-loop; other site 226186002413 ATP binding site [chemical binding]; other site 226186002414 Q-loop/lid; other site 226186002415 ABC transporter signature motif; other site 226186002416 Walker B; other site 226186002417 D-loop; other site 226186002418 H-loop/switch region; other site 226186002419 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 226186002420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002421 FtsX-like permease family; Region: FtsX; pfam02687 226186002422 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002423 FtsX-like permease family; Region: FtsX; pfam02687 226186002424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002425 FtsX-like permease family; Region: FtsX; pfam02687 226186002426 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002427 FtsX-like permease family; Region: FtsX; pfam02687 226186002428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002429 FtsX-like permease family; Region: FtsX; pfam02687 226186002430 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226186002431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002432 FtsX-like permease family; Region: FtsX; pfam02687 226186002433 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002434 FtsX-like permease family; Region: FtsX; pfam02687 226186002435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002436 FtsX-like permease family; Region: FtsX; pfam02687 226186002437 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002438 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002439 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186002440 sugar binding site [chemical binding]; other site 226186002441 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002442 SusD family; Region: SusD; pfam07980 226186002443 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002444 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186002445 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186002446 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186002447 Lipocalin-like; Region: Lipocalin_3; pfam12702 226186002448 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 226186002449 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226186002450 substrate-cofactor binding pocket; other site 226186002451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186002452 catalytic residue [active] 226186002453 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 226186002454 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226186002455 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 226186002456 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 226186002457 dimer interface [polypeptide binding]; other site 226186002458 anticodon binding site; other site 226186002459 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 226186002460 homodimer interface [polypeptide binding]; other site 226186002461 motif 1; other site 226186002462 active site 226186002463 motif 2; other site 226186002464 GAD domain; Region: GAD; pfam02938 226186002465 motif 3; other site 226186002466 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186002467 Sulfatase; Region: Sulfatase; cl19157 226186002468 GtrA-like protein; Region: GtrA; pfam04138 226186002469 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 226186002470 putative active site; other site 226186002471 catalytic triad [active] 226186002472 putative dimer interface [polypeptide binding]; other site 226186002473 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 226186002474 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl19624 226186002475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186002476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186002477 Walker A/P-loop; other site 226186002478 ATP binding site [chemical binding]; other site 226186002479 Q-loop/lid; other site 226186002480 ABC transporter signature motif; other site 226186002481 Walker B; other site 226186002482 D-loop; other site 226186002483 H-loop/switch region; other site 226186002484 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 226186002485 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 226186002486 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 226186002487 Putative zinc ribbon domain; Region: DUF164; pfam02591 226186002488 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186002489 Outer membrane efflux protein; Region: OEP; pfam02321 226186002490 Outer membrane efflux protein; Region: OEP; pfam02321 226186002491 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186002492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186002493 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186002494 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186002495 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186002496 MMPL family; Region: MMPL; cl14618 226186002497 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 226186002498 AMP nucleosidase; Provisional; Region: PRK07115 226186002499 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 226186002500 DNA polymerase III, delta subunit; Region: holA; TIGR01128 226186002501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186002502 non-specific DNA binding site [nucleotide binding]; other site 226186002503 salt bridge; other site 226186002504 sequence-specific DNA binding site [nucleotide binding]; other site 226186002505 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 226186002506 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 226186002507 FAD binding pocket [chemical binding]; other site 226186002508 FAD binding motif [chemical binding]; other site 226186002509 phosphate binding motif [ion binding]; other site 226186002510 beta-alpha-beta structure motif; other site 226186002511 NAD binding pocket [chemical binding]; other site 226186002512 Iron coordination center [ion binding]; other site 226186002513 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 226186002514 heterodimer interface [polypeptide binding]; other site 226186002515 active site 226186002516 FMN binding site [chemical binding]; other site 226186002517 homodimer interface [polypeptide binding]; other site 226186002518 substrate binding site [chemical binding]; other site 226186002519 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 226186002520 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 226186002521 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 226186002522 nucleotide binding pocket [chemical binding]; other site 226186002523 K-X-D-G motif; other site 226186002524 catalytic site [active] 226186002525 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 226186002526 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 226186002527 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226186002528 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 226186002529 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 226186002530 Dimer interface [polypeptide binding]; other site 226186002531 BRCT sequence motif; other site 226186002532 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 226186002533 dimer interface [polypeptide binding]; other site 226186002534 active site 226186002535 catalytic residue [active] 226186002536 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226186002537 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 226186002538 active site 226186002539 nucleophile elbow; other site 226186002540 heat shock protein 90; Provisional; Region: PRK05218 226186002541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002542 ATP binding site [chemical binding]; other site 226186002543 Mg2+ binding site [ion binding]; other site 226186002544 G-X-G motif; other site 226186002545 Hsp90 protein; Region: HSP90; pfam00183 226186002546 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 226186002547 Clp amino terminal domain; Region: Clp_N; pfam02861 226186002548 Clp amino terminal domain; Region: Clp_N; pfam02861 226186002549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002550 Walker A motif; other site 226186002551 ATP binding site [chemical binding]; other site 226186002552 Walker B motif; other site 226186002553 arginine finger; other site 226186002554 UvrB/uvrC motif; Region: UVR; pfam02151 226186002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002556 Walker A motif; other site 226186002557 ATP binding site [chemical binding]; other site 226186002558 Walker B motif; other site 226186002559 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226186002560 DNA gyrase subunit A; Validated; Region: PRK05560 226186002561 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226186002562 CAP-like domain; other site 226186002563 active site 226186002564 primary dimer interface [polypeptide binding]; other site 226186002565 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002566 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002567 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002568 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002569 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002570 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226186002571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186002572 binding surface 226186002573 TPR motif; other site 226186002574 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 226186002575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226186002576 Ligand Binding Site [chemical binding]; other site 226186002577 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226186002578 Ligand Binding Site [chemical binding]; other site 226186002579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186002580 binding surface 226186002581 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186002582 TPR motif; other site 226186002583 Bacterial SH3 domain; Region: SH3_3; pfam08239 226186002584 Oxygen tolerance; Region: BatD; pfam13584 226186002585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186002586 binding surface 226186002587 TPR motif; other site 226186002588 TPR repeat; Region: TPR_11; pfam13414 226186002589 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226186002590 metal ion-dependent adhesion site (MIDAS); other site 226186002591 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 226186002592 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 226186002593 metal ion-dependent adhesion site (MIDAS); other site 226186002594 Oxygen tolerance; Region: BatD; pfam13584 226186002595 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226186002596 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 226186002597 metal ion-dependent adhesion site (MIDAS); other site 226186002598 MoxR-like ATPases [General function prediction only]; Region: COG0714 226186002599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186002600 Walker A motif; other site 226186002601 ATP binding site [chemical binding]; other site 226186002602 Walker B motif; other site 226186002603 arginine finger; other site 226186002604 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 226186002605 DNA binding site [nucleotide binding] 226186002606 dimer interface [polypeptide binding]; other site 226186002607 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186002608 Integration host factor (IHF) and similar proteins; Region: IHF; cd13832 226186002609 DNA binding site [nucleotide binding] 226186002610 dimer interface [polypeptide binding]; other site 226186002611 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 226186002612 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226186002613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186002614 FeS/SAM binding site; other site 226186002615 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 226186002616 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 226186002617 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 226186002618 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226186002619 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 226186002620 competence damage-inducible protein A; Provisional; Region: PRK00549 226186002621 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 226186002622 putative MPT binding site; other site 226186002623 Competence-damaged protein; Region: CinA; pfam02464 226186002624 putative transposase OrfB; Reviewed; Region: PHA02517 226186002625 Integrase core domain; Region: rve; pfam00665 226186002626 Integrase core domain; Region: rve_3; pfam13683 226186002627 UGMP family protein; Validated; Region: PRK09604 226186002628 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226186002629 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 226186002630 Family of unknown function (DUF490); Region: DUF490; pfam04357 226186002631 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002632 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002633 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002634 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002635 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002636 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186002637 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 226186002638 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 226186002639 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226186002640 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226186002641 Walker A/P-loop; other site 226186002642 ATP binding site [chemical binding]; other site 226186002643 Q-loop/lid; other site 226186002644 ABC transporter signature motif; other site 226186002645 Walker B; other site 226186002646 D-loop; other site 226186002647 H-loop/switch region; other site 226186002648 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 226186002649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002651 dimer interface [polypeptide binding]; other site 226186002652 phosphorylation site [posttranslational modification] 226186002653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002654 ATP binding site [chemical binding]; other site 226186002655 Mg2+ binding site [ion binding]; other site 226186002656 G-X-G motif; other site 226186002657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186002658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002659 active site 226186002660 phosphorylation site [posttranslational modification] 226186002661 intermolecular recognition site; other site 226186002662 dimerization interface [polypeptide binding]; other site 226186002663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186002664 DNA binding site [nucleotide binding] 226186002665 prolyl-tRNA synthetase; Provisional; Region: PRK08661 226186002666 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 226186002667 dimer interface [polypeptide binding]; other site 226186002668 motif 1; other site 226186002669 active site 226186002670 motif 2; other site 226186002671 motif 3; other site 226186002672 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 226186002673 anticodon binding site; other site 226186002674 zinc-binding site [ion binding]; other site 226186002675 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 226186002676 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 226186002677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186002678 active site 226186002679 DNA binding site [nucleotide binding] 226186002680 Int/Topo IB signature motif; other site 226186002681 Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987 226186002682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186002683 active site 226186002684 DNA binding site [nucleotide binding] 226186002685 Int/Topo IB signature motif; other site 226186002686 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186002687 Outer membrane efflux protein; Region: OEP; pfam02321 226186002688 Outer membrane efflux protein; Region: OEP; pfam02321 226186002689 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 226186002690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186002691 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 226186002692 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186002693 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 226186002694 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226186002695 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226186002696 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226186002697 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226186002698 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186002699 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186002700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002702 dimer interface [polypeptide binding]; other site 226186002703 phosphorylation site [posttranslational modification] 226186002704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002705 ATP binding site [chemical binding]; other site 226186002706 Mg2+ binding site [ion binding]; other site 226186002707 G-X-G motif; other site 226186002708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186002709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002710 active site 226186002711 phosphorylation site [posttranslational modification] 226186002712 intermolecular recognition site; other site 226186002713 dimerization interface [polypeptide binding]; other site 226186002714 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186002715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186002716 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 226186002717 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 226186002718 N-terminal plug; other site 226186002719 ligand-binding site [chemical binding]; other site 226186002720 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 226186002721 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 226186002722 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226186002723 active site 226186002724 catalytic tetrad [active] 226186002725 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 226186002726 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186002727 4Fe-4S binding domain; Region: Fer4_5; pfam12801 226186002728 4Fe-4S binding domain; Region: Fer4_5; pfam12801 226186002729 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186002730 ferredoxin-type protein; Provisional; Region: PRK10194 226186002731 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186002732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186002733 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186002734 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186002735 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186002736 FecR protein; Region: FecR; pfam04773 226186002737 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186002738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186002739 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186002740 DNA binding residues [nucleotide binding] 226186002741 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 226186002742 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 226186002743 Beta-carotene 15,15'-dioxygenase; Region: BCD; cl14026 226186002744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186002745 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 226186002746 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 226186002747 short chain dehydrogenase; Validated; Region: PRK06182 226186002748 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 226186002749 NADP binding site [chemical binding]; other site 226186002750 active site 226186002751 steroid binding site; other site 226186002752 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 226186002753 Uncharacterized conserved protein [Function unknown]; Region: COG2966 226186002754 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 226186002755 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 226186002756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186002757 putative substrate translocation pore; other site 226186002758 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186002759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186002760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186002761 DNA binding residues [nucleotide binding] 226186002762 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 226186002763 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186002764 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186002765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002767 dimer interface [polypeptide binding]; other site 226186002768 phosphorylation site [posttranslational modification] 226186002769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002770 ATP binding site [chemical binding]; other site 226186002771 Mg2+ binding site [ion binding]; other site 226186002772 G-X-G motif; other site 226186002773 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226186002774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002775 active site 226186002776 phosphorylation site [posttranslational modification] 226186002777 intermolecular recognition site; other site 226186002778 dimerization interface [polypeptide binding]; other site 226186002779 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186002780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186002781 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002782 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186002783 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186002784 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186002785 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 226186002786 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186002787 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186002788 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002789 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186002790 catalytic residues [active] 226186002791 magnesium-transporting ATPase; Provisional; Region: PRK15122 226186002792 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 226186002793 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226186002794 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226186002795 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226186002796 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226186002797 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226186002798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226186002799 dimerization interface [polypeptide binding]; other site 226186002800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002801 dimer interface [polypeptide binding]; other site 226186002802 phosphorylation site [posttranslational modification] 226186002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002804 ATP binding site [chemical binding]; other site 226186002805 Mg2+ binding site [ion binding]; other site 226186002806 G-X-G motif; other site 226186002807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186002809 active site 226186002810 phosphorylation site [posttranslational modification] 226186002811 intermolecular recognition site; other site 226186002812 dimerization interface [polypeptide binding]; other site 226186002813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186002814 DNA binding site [nucleotide binding] 226186002815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 226186002816 ACT domain; Region: ACT_3; pfam10000 226186002817 ACT domain; Region: ACT_7; pfam13840 226186002818 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002819 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186002820 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186002821 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 226186002822 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226186002823 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002824 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186002825 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186002826 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186002827 PAS domain; Region: PAS_9; pfam13426 226186002828 PAS fold; Region: PAS_3; pfam08447 226186002829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226186002830 putative active site [active] 226186002831 heme pocket [chemical binding]; other site 226186002832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186002833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002834 dimer interface [polypeptide binding]; other site 226186002835 phosphorylation site [posttranslational modification] 226186002836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002837 ATP binding site [chemical binding]; other site 226186002838 Mg2+ binding site [ion binding]; other site 226186002839 G-X-G motif; other site 226186002840 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186002841 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186002842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186002843 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186002844 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186002845 active site 226186002846 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186002847 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186002848 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186002849 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 226186002850 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 226186002851 metal binding site [ion binding]; metal-binding site 226186002852 GAF domain; Region: GAF; pfam01590 226186002853 PAS domain S-box; Region: sensory_box; TIGR00229 226186002854 PAS domain; Region: PAS; smart00091 226186002855 PAS fold; Region: PAS_3; pfam08447 226186002856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186002857 dimer interface [polypeptide binding]; other site 226186002858 phosphorylation site [posttranslational modification] 226186002859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186002860 ATP binding site [chemical binding]; other site 226186002861 Mg2+ binding site [ion binding]; other site 226186002862 G-X-G motif; other site 226186002863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226186002864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226186002865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186002866 FtsX-like permease family; Region: FtsX; pfam02687 226186002867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186002868 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186002869 FtsX-like permease family; Region: FtsX; pfam02687 226186002870 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186002871 Right handed beta helix region; Region: Beta_helix; pfam13229 226186002872 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186002873 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 226186002874 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226186002875 dimer interface [polypeptide binding]; other site 226186002876 FMN binding site [chemical binding]; other site 226186002877 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 226186002878 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 226186002879 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226186002880 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 226186002881 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186002882 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 226186002883 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 226186002884 active site 226186002885 catalytic residues [active] 226186002886 FMN binding site [chemical binding]; other site 226186002887 quinone interaction residues [chemical binding]; other site 226186002888 substrate binding site [chemical binding]; other site 226186002889 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186002890 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186002891 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 226186002892 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 226186002893 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 226186002894 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186002895 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 226186002896 BNR repeat-like domain; Region: BNR_2; pfam13088 226186002897 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186002898 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186002899 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226186002900 classical (c) SDRs; Region: SDR_c; cd05233 226186002901 NAD(P) binding site [chemical binding]; other site 226186002902 active site 226186002903 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226186002904 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 226186002905 active site 226186002906 nucleophile elbow; other site 226186002907 Protein of unknown function (DUF3826); Region: DUF3826; pfam12875 226186002908 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226186002909 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186002910 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186002911 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 226186002912 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186002913 BNR repeat-like domain; Region: BNR_2; pfam13088 226186002914 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 226186002915 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186002916 active site 226186002917 Protein of unknown function (DUF3826); Region: DUF3826; pfam12875 226186002918 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002919 SusD family; Region: SusD; pfam07980 226186002920 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002921 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186002922 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186002923 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186002924 SusD family; Region: SusD; pfam07980 226186002925 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002926 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186002927 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186002928 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186002929 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226186002930 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226186002931 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186002932 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186002933 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186002934 active site 226186002935 muropeptide transporter; Reviewed; Region: ampG; cl17669 226186002936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186002937 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 226186002938 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186002939 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002940 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002941 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002942 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186002943 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186002944 active site 226186002945 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186002946 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186002947 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002948 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002949 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186002950 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186002951 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186002952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186002953 active site 226186002954 DNA binding site [nucleotide binding] 226186002955 Int/Topo IB signature motif; other site 226186002956 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186002957 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002958 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186002959 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186002960 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186002961 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002962 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186002963 active site 226186002964 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002965 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186002966 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186002967 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186002968 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186002969 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186002970 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186002971 active site 226186002972 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186002973 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186002974 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186002975 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186002976 sugar binding site [chemical binding]; other site 226186002977 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 226186002978 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186002979 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186002980 active site 226186002981 Fn3 associated; Region: Fn3_assoc; pfam13287 226186002982 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186002983 sugar binding site [chemical binding]; other site 226186002984 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186002985 FecR protein; Region: FecR; pfam04773 226186002986 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186002987 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186002988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186002989 DNA binding residues [nucleotide binding] 226186002990 Part of AAA domain; Region: AAA_19; pfam13245 226186002991 putative recombination protein RecB; Provisional; Region: PRK13909 226186002992 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 226186002993 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 226186002994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186002995 Radical SAM superfamily; Region: Radical_SAM; pfam04055 226186002996 FeS/SAM binding site; other site 226186002997 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186002998 probable DNA repair protein; Region: TIGR03623 226186002999 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 226186003000 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 226186003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003002 active site 226186003003 phosphorylation site [posttranslational modification] 226186003004 intermolecular recognition site; other site 226186003005 dimerization interface [polypeptide binding]; other site 226186003006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186003007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186003008 dimer interface [polypeptide binding]; other site 226186003009 phosphorylation site [posttranslational modification] 226186003010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186003011 ATP binding site [chemical binding]; other site 226186003012 Mg2+ binding site [ion binding]; other site 226186003013 G-X-G motif; other site 226186003014 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186003015 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 226186003016 NAD binding site [chemical binding]; other site 226186003017 putative substrate binding site 2 [chemical binding]; other site 226186003018 putative substrate binding site 1 [chemical binding]; other site 226186003019 active site 226186003020 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186003021 Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321 226186003022 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal; Region: Fimbrillin_C; pfam15495 226186003023 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186003024 ligand binding site [chemical binding]; other site 226186003025 Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984 226186003026 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186003027 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226186003028 ParB-like nuclease domain; Region: ParB; smart00470 226186003029 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 226186003030 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226186003031 Active Sites [active] 226186003032 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 226186003033 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 226186003034 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 226186003035 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186003036 Histidine kinase; Region: His_kinase; pfam06580 226186003037 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186003038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003039 active site 226186003040 phosphorylation site [posttranslational modification] 226186003041 intermolecular recognition site; other site 226186003042 dimerization interface [polypeptide binding]; other site 226186003043 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186003044 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 226186003045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003047 homodimer interface [polypeptide binding]; other site 226186003048 catalytic residue [active] 226186003049 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 226186003050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226186003051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186003052 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 226186003053 Coenzyme A binding pocket [chemical binding]; other site 226186003054 recombination protein RecR; Reviewed; Region: recR; PRK00076 226186003055 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226186003056 RecR protein; Region: RecR; pfam02132 226186003057 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 226186003058 putative active site [active] 226186003059 putative metal-binding site [ion binding]; other site 226186003060 tetramer interface [polypeptide binding]; other site 226186003061 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 226186003062 Na binding site [ion binding]; other site 226186003063 Predicted GTPase [General function prediction only]; Region: COG0218 226186003064 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 226186003065 G1 box; other site 226186003066 GTP/Mg2+ binding site [chemical binding]; other site 226186003067 Switch I region; other site 226186003068 G2 box; other site 226186003069 G3 box; other site 226186003070 Switch II region; other site 226186003071 G4 box; other site 226186003072 G5 box; other site 226186003073 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 226186003074 OPT oligopeptide transporter protein; Region: OPT; pfam03169 226186003075 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186003076 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186003077 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 226186003078 lipoate-protein ligase B; Provisional; Region: PRK14348 226186003079 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186003080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186003081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226186003082 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226186003083 metal-binding site [ion binding] 226186003084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226186003085 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226186003086 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226186003087 metal-binding site [ion binding] 226186003088 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186003089 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186003090 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186003091 DDE superfamily endonuclease; Region: DDE_Tnp_4; pfam13359 226186003092 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 226186003093 active site 226186003094 dimer interfaces [polypeptide binding]; other site 226186003095 catalytic residues [active] 226186003096 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 226186003097 active site 226186003098 metal binding site [ion binding]; metal-binding site 226186003099 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003100 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 226186003101 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226186003102 TrkA-C domain; Region: TrkA_C; pfam02080 226186003103 TrkA-C domain; Region: TrkA_C; pfam02080 226186003104 6-phosphofructokinase; Provisional; Region: PRK03202 226186003105 active site 226186003106 ADP/pyrophosphate binding site [chemical binding]; other site 226186003107 dimerization interface [polypeptide binding]; other site 226186003108 allosteric effector site; other site 226186003109 fructose-1,6-bisphosphate binding site; other site 226186003110 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 226186003111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186003112 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226186003113 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 226186003114 putative dimer interface [polypeptide binding]; other site 226186003115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226186003116 catalytic core [active] 226186003117 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 226186003118 putative active site; other site 226186003119 catalytic residue [active] 226186003120 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 226186003121 Ferritin-like domain; Region: Ferritin; pfam00210 226186003122 ferroxidase diiron center [ion binding]; other site 226186003123 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 226186003124 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 226186003125 Ferritin-like domain; Region: Ferritin; pfam00210 226186003126 dinuclear metal binding motif [ion binding]; other site 226186003127 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 226186003128 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226186003129 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 226186003130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226186003131 catalytic site [active] 226186003132 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 226186003133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226186003134 active site 226186003135 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226186003136 catalytic tetrad [active] 226186003137 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 226186003138 trimer interface [polypeptide binding]; other site 226186003139 putative Zn binding site [ion binding]; other site 226186003140 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186003141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186003142 ligand binding site [chemical binding]; other site 226186003143 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186003144 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186003145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186003146 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 226186003147 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 226186003148 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 226186003149 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186003150 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 226186003151 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 226186003152 structural tetrad; other site 226186003153 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186003154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186003155 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186003156 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186003157 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 226186003158 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186003159 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186003160 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186003161 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226186003162 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186003163 Int/Topo IB signature motif; other site 226186003164 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186003165 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186003166 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226186003167 probable metal-binding protein; Region: matur_matur; TIGR03853 226186003168 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 226186003169 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 226186003170 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226186003171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186003172 S-adenosylmethionine binding site [chemical binding]; other site 226186003173 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226186003174 glycine dehydrogenase; Provisional; Region: PRK05367 226186003175 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226186003176 tetramer interface [polypeptide binding]; other site 226186003177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003178 catalytic residue [active] 226186003179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226186003180 tetramer interface [polypeptide binding]; other site 226186003181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003182 catalytic residue [active] 226186003183 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 226186003184 FMN binding site [chemical binding]; other site 226186003185 dimer interface [polypeptide binding]; other site 226186003186 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 226186003187 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 226186003188 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 226186003189 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 226186003190 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226186003191 NAD binding site [chemical binding]; other site 226186003192 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 226186003193 homodimer interface [polypeptide binding]; other site 226186003194 substrate-cofactor binding pocket; other site 226186003195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003196 catalytic residue [active] 226186003197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 226186003198 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 226186003199 ATP binding site [chemical binding]; other site 226186003200 putative Mg++ binding site [ion binding]; other site 226186003201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186003202 nucleotide binding region [chemical binding]; other site 226186003203 ATP-binding site [chemical binding]; other site 226186003204 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 226186003205 RNA binding site [nucleotide binding]; other site 226186003206 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 226186003207 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226186003208 catalytic loop [active] 226186003209 iron binding site [ion binding]; other site 226186003210 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 226186003211 FAD binding pocket [chemical binding]; other site 226186003212 FAD binding motif [chemical binding]; other site 226186003213 phosphate binding motif [ion binding]; other site 226186003214 beta-alpha-beta structure motif; other site 226186003215 NAD binding pocket [chemical binding]; other site 226186003216 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 226186003217 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 226186003218 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 226186003219 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 226186003220 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 226186003221 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 226186003222 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 226186003223 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 226186003224 trimer interface [polypeptide binding]; other site 226186003225 active site 226186003226 G bulge; other site 226186003227 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186003228 Outer membrane efflux protein; Region: OEP; pfam02321 226186003229 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 226186003230 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 226186003231 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 226186003232 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226186003233 Probable Catalytic site; other site 226186003234 metal-binding site 226186003235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186003236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186003237 active site 226186003238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186003239 amidase catalytic site [active] 226186003240 Zn binding residues [ion binding]; other site 226186003241 substrate binding site [chemical binding]; other site 226186003242 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186003243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226186003244 active site 226186003245 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 226186003246 active site 226186003247 metal binding site [ion binding]; metal-binding site 226186003248 interdomain interaction site; other site 226186003249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226186003250 Walker A motif; other site 226186003251 ATP binding site [chemical binding]; other site 226186003252 Walker B motif; other site 226186003253 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186003254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186003255 non-specific DNA binding site [nucleotide binding]; other site 226186003256 salt bridge; other site 226186003257 sequence-specific DNA binding site [nucleotide binding]; other site 226186003258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003260 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186003261 putative glycosyl transferase; Provisional; Region: PRK10073 226186003262 active site 226186003263 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186003264 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186003265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003266 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 226186003267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186003268 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 226186003269 putative ADP-binding pocket [chemical binding]; other site 226186003270 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186003271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186003272 active site 226186003273 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cd10585 226186003274 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226186003275 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 226186003276 DXD motif; other site 226186003277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226186003278 putative active site [active] 226186003279 heme pocket [chemical binding]; other site 226186003280 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 226186003281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186003282 dimer interface [polypeptide binding]; other site 226186003283 phosphorylation site [posttranslational modification] 226186003284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186003285 ATP binding site [chemical binding]; other site 226186003286 Mg2+ binding site [ion binding]; other site 226186003287 G-X-G motif; other site 226186003288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003289 active site 226186003290 phosphorylation site [posttranslational modification] 226186003291 intermolecular recognition site; other site 226186003292 dimerization interface [polypeptide binding]; other site 226186003293 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 226186003294 putative catalytic site [active] 226186003295 putative metal binding site [ion binding]; other site 226186003296 putative phosphate binding site [ion binding]; other site 226186003297 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186003298 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186003299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186003300 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 226186003301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186003302 ABC transporter; Region: ABC_tran_2; pfam12848 226186003303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186003304 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 226186003305 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186003306 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226186003307 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226186003308 GTPase RsgA; Reviewed; Region: PRK01889 226186003309 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226186003310 RNA binding site [nucleotide binding]; other site 226186003311 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 226186003312 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226186003313 GTP/Mg2+ binding site [chemical binding]; other site 226186003314 G4 box; other site 226186003315 G5 box; other site 226186003316 G1 box; other site 226186003317 Switch I region; other site 226186003318 G2 box; other site 226186003319 G3 box; other site 226186003320 Switch II region; other site 226186003321 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 226186003322 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186003323 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186003324 sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827 226186003325 active site 226186003326 catalytic triad [active] 226186003327 oxyanion hole [active] 226186003328 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186003329 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 226186003330 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186003331 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186003332 ligand binding site [chemical binding]; other site 226186003333 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 226186003334 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 226186003335 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 226186003336 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 226186003337 active site 226186003338 catalytic residues [active] 226186003339 metal binding site [ion binding]; metal-binding site 226186003340 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226186003341 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 226186003342 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186003343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186003344 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186003345 DNA binding residues [nucleotide binding] 226186003346 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 226186003347 Peptidase family M48; Region: Peptidase_M48; cl12018 226186003348 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 226186003349 Predicted membrane protein [Function unknown]; Region: COG2860 226186003350 UPF0126 domain; Region: UPF0126; pfam03458 226186003351 UPF0126 domain; Region: UPF0126; pfam03458 226186003352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003354 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186003355 recombination factor protein RarA; Reviewed; Region: PRK13342 226186003356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186003357 Walker A motif; other site 226186003358 ATP binding site [chemical binding]; other site 226186003359 Walker B motif; other site 226186003360 arginine finger; other site 226186003361 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 226186003362 hypothetical protein; Reviewed; Region: PRK12275 226186003363 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 226186003364 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 226186003365 putative ligand binding site [chemical binding]; other site 226186003366 putative NAD binding site [chemical binding]; other site 226186003367 catalytic site [active] 226186003368 Protein of unknown function (DUF805); Region: DUF805; pfam05656 226186003369 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226186003370 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226186003371 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 226186003372 Domain of unknown function (DUF4492); Region: DUF4492; pfam14899 226186003373 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186003374 Outer membrane efflux protein; Region: OEP; pfam02321 226186003375 Outer membrane efflux protein; Region: OEP; pfam02321 226186003376 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186003377 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186003378 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186003379 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186003380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186003381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186003382 Walker A/P-loop; other site 226186003383 ATP binding site [chemical binding]; other site 226186003384 Q-loop/lid; other site 226186003385 ABC transporter signature motif; other site 226186003386 Walker B; other site 226186003387 D-loop; other site 226186003388 H-loop/switch region; other site 226186003389 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186003390 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186003391 FtsX-like permease family; Region: FtsX; pfam02687 226186003392 Histidine kinase; Region: His_kinase; pfam06580 226186003393 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186003394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003395 active site 226186003396 phosphorylation site [posttranslational modification] 226186003397 intermolecular recognition site; other site 226186003398 dimerization interface [polypeptide binding]; other site 226186003399 LytTr DNA-binding domain; Region: LytTR; smart00850 226186003400 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 226186003401 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 226186003402 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 226186003403 putative active site [active] 226186003404 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 226186003405 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 226186003406 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 226186003407 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226186003408 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 226186003409 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 226186003410 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 226186003411 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 226186003412 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 226186003413 NADP-binding site; other site 226186003414 homotetramer interface [polypeptide binding]; other site 226186003415 substrate binding site [chemical binding]; other site 226186003416 homodimer interface [polypeptide binding]; other site 226186003417 active site 226186003418 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 226186003419 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 226186003420 NADP binding site [chemical binding]; other site 226186003421 active site 226186003422 putative substrate binding site [chemical binding]; other site 226186003423 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 226186003424 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226186003425 acyl-activating enzyme (AAE) consensus motif; other site 226186003426 AMP binding site [chemical binding]; other site 226186003427 active site 226186003428 CoA binding site [chemical binding]; other site 226186003429 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 226186003430 putative transporter; Validated; Region: PRK03818 226186003431 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186003432 TrkA-C domain; Region: TrkA_C; pfam02080 226186003433 TrkA-C domain; Region: TrkA_C; pfam02080 226186003434 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186003435 Domain of Unknown Function with PDB structure; Region: DUF3845; pfam12956 226186003436 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186003437 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 226186003438 ligand binding site [chemical binding]; other site 226186003439 flexible hinge region; other site 226186003440 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186003441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186003442 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226186003443 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 226186003444 active site 226186003445 metal binding site [ion binding]; metal-binding site 226186003446 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226186003447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186003448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186003449 dimer interface [polypeptide binding]; other site 226186003450 phosphorylation site [posttranslational modification] 226186003451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186003452 ATP binding site [chemical binding]; other site 226186003453 Mg2+ binding site [ion binding]; other site 226186003454 G-X-G motif; other site 226186003455 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 226186003456 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 226186003457 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 226186003458 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 226186003459 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186003460 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 226186003461 RNA binding site [nucleotide binding]; other site 226186003462 CAAX protease self-immunity; Region: Abi; pfam02517 226186003463 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186003464 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 226186003465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186003466 ABC transporter; Region: ABC_tran_2; pfam12848 226186003467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186003468 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 226186003469 dimer interface [polypeptide binding]; other site 226186003470 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 226186003471 chaperone protein DnaJ; Provisional; Region: PRK14289 226186003472 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226186003473 HSP70 interaction site [polypeptide binding]; other site 226186003474 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 226186003475 substrate binding site [polypeptide binding]; other site 226186003476 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 226186003477 Zn binding sites [ion binding]; other site 226186003478 dimer interface [polypeptide binding]; other site 226186003479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186003480 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186003481 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186003482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186003483 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 226186003484 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226186003485 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 226186003486 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186003487 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186003488 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186003489 Outer membrane efflux protein; Region: OEP; pfam02321 226186003490 Outer membrane efflux protein; Region: OEP; pfam02321 226186003491 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186003492 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226186003493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186003494 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 226186003495 Inner membrane protein CreD; Region: CreD; pfam06123 226186003496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 226186003497 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186003498 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 226186003499 ADP-ribose binding site [chemical binding]; other site 226186003500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186003501 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226186003502 Coenzyme A binding pocket [chemical binding]; other site 226186003503 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 226186003504 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 226186003505 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 226186003506 Putative esterase; Region: Esterase; pfam00756 226186003507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186003508 Predicted transcriptional regulators [Transcription]; Region: COG1733 226186003509 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186003510 intracellular protease, PfpI family; Region: PfpI; TIGR01382 226186003511 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226186003512 conserved cys residue [active] 226186003513 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 226186003514 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 226186003515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186003516 dimer interface [polypeptide binding]; other site 226186003517 phosphorylation site [posttranslational modification] 226186003518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186003519 ATP binding site [chemical binding]; other site 226186003520 Mg2+ binding site [ion binding]; other site 226186003521 G-X-G motif; other site 226186003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003523 active site 226186003524 phosphorylation site [posttranslational modification] 226186003525 intermolecular recognition site; other site 226186003526 dimerization interface [polypeptide binding]; other site 226186003527 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003529 active site 226186003530 phosphorylation site [posttranslational modification] 226186003531 intermolecular recognition site; other site 226186003532 dimerization interface [polypeptide binding]; other site 226186003533 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186003534 Histidine kinase; Region: His_kinase; pfam06580 226186003535 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186003536 Outer membrane efflux protein; Region: OEP; pfam02321 226186003537 Outer membrane efflux protein; Region: OEP; pfam02321 226186003538 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186003539 MMPL family; Region: MMPL; cl14618 226186003540 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186003541 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186003542 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 226186003543 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226186003544 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226186003545 ribosomal protein S16; Region: S16; TIGR00002 226186003546 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14523 226186003547 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226186003548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226186003549 DNA-binding site [nucleotide binding]; DNA binding site 226186003550 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 226186003551 putative dimerization interface [polypeptide binding]; other site 226186003552 putative ligand binding site [chemical binding]; other site 226186003553 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226186003554 L-fucose isomerase; Provisional; Region: fucI; PRK10991 226186003555 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 226186003556 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186003557 trimer interface [polypeptide binding]; other site 226186003558 substrate binding site [chemical binding]; other site 226186003559 Mn binding site [ion binding]; other site 226186003560 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 226186003561 active site 226186003562 intersubunit interface [polypeptide binding]; other site 226186003563 Zn2+ binding site [ion binding]; other site 226186003564 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 226186003565 N- and C-terminal domain interface [polypeptide binding]; other site 226186003566 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 226186003567 active site 226186003568 putative catalytic site [active] 226186003569 metal binding site [ion binding]; metal-binding site 226186003570 ATP binding site [chemical binding]; other site 226186003571 carbohydrate binding site [chemical binding]; other site 226186003572 Domain of unknown function (DUF718); Region: DUF718; pfam05336 226186003573 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186003574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186003575 putative substrate translocation pore; other site 226186003576 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186003577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186003578 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186003579 DNA binding residues [nucleotide binding] 226186003580 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186003581 FecR protein; Region: FecR; pfam04773 226186003582 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186003583 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186003584 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186003585 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186003586 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186003587 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186003588 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186003589 active site 226186003590 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186003591 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186003592 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186003593 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186003594 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186003595 active site 226186003596 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186003597 active site 226186003598 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186003599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186003600 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186003601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003602 active site 226186003603 phosphorylation site [posttranslational modification] 226186003604 intermolecular recognition site; other site 226186003605 dimerization interface [polypeptide binding]; other site 226186003606 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186003607 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 226186003608 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226186003609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226186003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226186003611 dimer interface [polypeptide binding]; other site 226186003612 conserved gate region; other site 226186003613 putative PBP binding loops; other site 226186003614 ABC-ATPase subunit interface; other site 226186003615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226186003616 dimer interface [polypeptide binding]; other site 226186003617 conserved gate region; other site 226186003618 putative PBP binding loops; other site 226186003619 ABC-ATPase subunit interface; other site 226186003620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226186003621 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 226186003622 Walker A/P-loop; other site 226186003623 ATP binding site [chemical binding]; other site 226186003624 Q-loop/lid; other site 226186003625 ABC transporter signature motif; other site 226186003626 Walker B; other site 226186003627 D-loop; other site 226186003628 H-loop/switch region; other site 226186003629 TOBE domain; Region: TOBE_2; pfam08402 226186003630 TOBE domain; Region: TOBE_2; pfam08402 226186003631 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 226186003632 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186003633 catalytic residues [active] 226186003634 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 226186003635 putative homodimer interface [polypeptide binding]; other site 226186003636 putative active site pocket [active] 226186003637 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 226186003638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003639 Glycogen synthase; Region: Glycogen_syn; pfam05693 226186003640 V-type ATP synthase subunit K; Validated; Region: PRK08344 226186003641 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 226186003642 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 226186003643 V-type ATP synthase subunit I; Validated; Region: PRK05771 226186003644 organizer of macrodomain of Terminus of chromosome; Region: MatP; cl11476 226186003645 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 226186003646 V-type ATP synthase subunit D; Provisional; Region: PRK02195 226186003647 V-type ATP synthase subunit B; Provisional; Region: PRK02118 226186003648 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226186003649 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 226186003650 Walker A motif homologous position; other site 226186003651 Walker B motif; other site 226186003652 V-type ATP synthase subunit A; Provisional; Region: PRK04192 226186003653 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226186003654 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 226186003655 Walker A motif/ATP binding site; other site 226186003656 Walker B motif; other site 226186003657 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226186003658 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 226186003659 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 226186003660 V-type ATP synthase subunit E; Provisional; Region: PRK01558 226186003661 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226186003662 Predicted transcriptional regulators [Transcription]; Region: COG1725 226186003663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226186003664 DNA-binding site [nucleotide binding]; DNA binding site 226186003665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226186003666 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226186003667 Walker A/P-loop; other site 226186003668 ATP binding site [chemical binding]; other site 226186003669 Q-loop/lid; other site 226186003670 ABC transporter signature motif; other site 226186003671 Walker B; other site 226186003672 D-loop; other site 226186003673 H-loop/switch region; other site 226186003674 Clostripain family; Region: Peptidase_C11; pfam03415 226186003675 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 226186003676 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 226186003677 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 226186003678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186003679 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226186003680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186003681 DNA binding residues [nucleotide binding] 226186003682 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 226186003683 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226186003684 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226186003685 protein binding site [polypeptide binding]; other site 226186003686 PDZ-like domain; Region: PDZ_1; pfam12812 226186003687 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 226186003688 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226186003689 active site 226186003690 Bacterial SH3 domain; Region: SH3_3; pfam08239 226186003691 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226186003692 NlpC/P60 family; Region: NLPC_P60; pfam00877 226186003693 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 226186003694 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 226186003695 putative FMN binding site [chemical binding]; other site 226186003696 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 226186003697 Lumazine binding domain; Region: Lum_binding; pfam00677 226186003698 Lumazine binding domain; Region: Lum_binding; pfam00677 226186003699 Histidine kinase; Region: His_kinase; pfam06580 226186003700 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186003701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186003702 active site 226186003703 phosphorylation site [posttranslational modification] 226186003704 intermolecular recognition site; other site 226186003705 dimerization interface [polypeptide binding]; other site 226186003706 LytTr DNA-binding domain; Region: LytTR; smart00850 226186003707 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 226186003708 PhoU domain; Region: PhoU; pfam01895 226186003709 PhoU domain; Region: PhoU; pfam01895 226186003710 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14245 226186003711 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 226186003712 Walker A/P-loop; other site 226186003713 ATP binding site [chemical binding]; other site 226186003714 Q-loop/lid; other site 226186003715 ABC transporter signature motif; other site 226186003716 Walker B; other site 226186003717 D-loop; other site 226186003718 H-loop/switch region; other site 226186003719 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226186003720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226186003721 dimer interface [polypeptide binding]; other site 226186003722 conserved gate region; other site 226186003723 putative PBP binding loops; other site 226186003724 ABC-ATPase subunit interface; other site 226186003725 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226186003726 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 226186003727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226186003728 dimer interface [polypeptide binding]; other site 226186003729 conserved gate region; other site 226186003730 putative PBP binding loops; other site 226186003731 ABC-ATPase subunit interface; other site 226186003732 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226186003733 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 226186003734 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226186003735 active site 226186003736 nucleotide binding site [chemical binding]; other site 226186003737 HIGH motif; other site 226186003738 KMSKS motif; other site 226186003739 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 226186003740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003741 binding surface 226186003742 TPR motif; other site 226186003743 TPR repeat; Region: TPR_11; pfam13414 226186003744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003745 binding surface 226186003746 TPR motif; other site 226186003747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186003749 binding surface 226186003750 TPR motif; other site 226186003751 TPR repeat; Region: TPR_11; pfam13414 226186003752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003753 binding surface 226186003754 TPR motif; other site 226186003755 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226186003756 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 226186003757 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 226186003758 dimer interface [polypeptide binding]; other site 226186003759 catalytic triad [active] 226186003760 peroxidatic and resolving cysteines [active] 226186003761 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 226186003762 Domain of unknown function (DUF4494); Region: DUF4494; pfam14902 226186003763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 226186003764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226186003765 catalytic residue [active] 226186003766 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 226186003767 putative active site [active] 226186003768 putative FMN binding site [chemical binding]; other site 226186003769 putative substrate binding site [chemical binding]; other site 226186003770 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 226186003771 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 226186003772 putative active site [active] 226186003773 PhoH-like protein; Region: PhoH; cl17668 226186003774 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 226186003775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186003776 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226186003777 homotrimer interaction site [polypeptide binding]; other site 226186003778 putative active site [active] 226186003779 Protein of unknown function (DUF805); Region: DUF805; pfam05656 226186003780 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 226186003781 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 226186003782 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 226186003783 Mg++ binding site [ion binding]; other site 226186003784 putative catalytic motif [active] 226186003785 substrate binding site [chemical binding]; other site 226186003786 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226186003787 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186003788 Probable Catalytic site; other site 226186003789 metal-binding site 226186003790 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 226186003791 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 226186003792 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186003793 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186003794 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186003795 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 226186003796 putative NAD(P) binding site [chemical binding]; other site 226186003797 active site 226186003798 putative substrate binding site [chemical binding]; other site 226186003799 EpsG family; Region: EpsG; pfam14897 226186003800 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186003801 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186003802 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 226186003803 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226186003804 putative active site [active] 226186003805 putative metal binding site [ion binding]; other site 226186003806 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 226186003807 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 226186003808 Probable Catalytic site; other site 226186003809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186003810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186003811 NAD(P) binding site [chemical binding]; other site 226186003812 active site 226186003813 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 226186003814 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 226186003815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186003816 NAD(P) binding site [chemical binding]; other site 226186003817 active site 226186003818 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226186003819 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 226186003820 substrate binding site; other site 226186003821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186003822 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 226186003823 putative ADP-binding pocket [chemical binding]; other site 226186003824 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186003825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186003826 active site 226186003827 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186003828 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186003829 Chain length determinant protein; Region: Wzz; pfam02706 226186003830 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186003831 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 226186003832 SLBB domain; Region: SLBB; pfam10531 226186003833 SLBB domain; Region: SLBB; pfam10531 226186003834 SLBB domain; Region: SLBB; pfam10531 226186003835 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 226186003836 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 226186003837 Transcription antiterminator [Transcription]; Region: NusG; COG0250 226186003838 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186003839 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 226186003840 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226186003841 TPR repeat; Region: TPR_11; pfam13414 226186003842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003843 TPR repeat; Region: TPR_11; pfam13414 226186003844 binding surface 226186003845 TPR motif; other site 226186003846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186003847 binding surface 226186003848 TPR motif; other site 226186003849 Tetratricopeptide repeat; Region: TPR_19; pfam14559 226186003850 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226186003851 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 226186003852 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226186003853 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 226186003854 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 226186003855 Walker A/P-loop; other site 226186003856 ATP binding site [chemical binding]; other site 226186003857 Q-loop/lid; other site 226186003858 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 226186003859 ABC transporter signature motif; other site 226186003860 Walker B; other site 226186003861 D-loop; other site 226186003862 H-loop/switch region; other site 226186003863 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 226186003864 Flavoprotein; Region: Flavoprotein; cl19190 226186003865 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 226186003866 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 226186003867 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226186003868 active site 226186003869 catalytic site [active] 226186003870 substrate binding site [chemical binding]; other site 226186003871 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226186003872 DNA polymerase III subunit beta; Validated; Region: PRK05643 226186003873 putative DNA binding surface [nucleotide binding]; other site 226186003874 dimer interface [polypeptide binding]; other site 226186003875 beta-clamp/translesion DNA polymerase binding surface; other site 226186003876 beta-clamp/clamp loader binding surface; other site 226186003877 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 226186003878 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 226186003879 putative hydrolase; Provisional; Region: PRK02113 226186003880 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 226186003881 FAD binding domain; Region: FAD_binding_4; cl19922 226186003882 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226186003883 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 226186003884 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186003885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186003886 NAD(P) binding site [chemical binding]; other site 226186003887 active site 226186003888 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 226186003889 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226186003890 substrate-cofactor binding pocket; other site 226186003891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003892 catalytic residue [active] 226186003893 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 226186003894 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 226186003895 Ferritin-like domain; Region: Ferritin; pfam00210 226186003896 ferroxidase diiron center [ion binding]; other site 226186003897 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 226186003898 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 226186003899 active site 226186003900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226186003901 substrate binding site [chemical binding]; other site 226186003902 catalytic residues [active] 226186003903 dimer interface [polypeptide binding]; other site 226186003904 aspartate kinase III; Validated; Region: PRK09084 226186003905 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 226186003906 putative catalytic residues [active] 226186003907 nucleotide binding site [chemical binding]; other site 226186003908 aspartate binding site [chemical binding]; other site 226186003909 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 226186003910 dimer interface [polypeptide binding]; other site 226186003911 allosteric regulatory binding pocket; other site 226186003912 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 226186003913 dimer interface [polypeptide binding]; other site 226186003914 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226186003915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186003916 Walker A/P-loop; other site 226186003917 ATP binding site [chemical binding]; other site 226186003918 Q-loop/lid; other site 226186003919 ABC transporter signature motif; other site 226186003920 Walker B; other site 226186003921 D-loop; other site 226186003922 H-loop/switch region; other site 226186003923 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 226186003924 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 226186003925 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 226186003926 metal binding site [ion binding]; metal-binding site 226186003927 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 226186003928 substrate binding site [chemical binding]; other site 226186003929 glutamase interaction surface [polypeptide binding]; other site 226186003930 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 226186003931 catalytic residues [active] 226186003932 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 226186003933 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 226186003934 putative active site [active] 226186003935 oxyanion strand; other site 226186003936 catalytic triad [active] 226186003937 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 226186003938 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 226186003939 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 226186003940 putative active site [active] 226186003941 putative substrate binding site [chemical binding]; other site 226186003942 putative cosubstrate binding site; other site 226186003943 catalytic site [active] 226186003944 intracellular protease, PfpI family; Region: PfpI; TIGR01382 226186003945 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 226186003946 conserved cys residue [active] 226186003947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226186003948 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226186003949 active site 226186003950 catalytic tetrad [active] 226186003951 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 226186003952 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186003953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186003954 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186003955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186003956 ligand binding site [chemical binding]; other site 226186003957 flexible hinge region; other site 226186003958 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186003959 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 226186003960 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226186003961 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186003962 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186003963 ligand binding site [chemical binding]; other site 226186003964 flexible hinge region; other site 226186003965 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 226186003966 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186003967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186003968 ligand binding site [chemical binding]; other site 226186003969 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186003970 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 226186003971 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 226186003972 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 226186003973 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226186003974 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226186003975 Uncharacterized conserved protein [Function unknown]; Region: COG4925 226186003976 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186003977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186003978 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 226186003979 EamA-like transporter family; Region: EamA; pfam00892 226186003980 EamA-like transporter family; Region: EamA; pfam00892 226186003981 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 226186003982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186003983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186003984 homodimer interface [polypeptide binding]; other site 226186003985 catalytic residue [active] 226186003986 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 226186003987 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 226186003988 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186003989 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226186003990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186003991 putative substrate translocation pore; other site 226186003992 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 226186003993 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 226186003994 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 226186003995 TPP-binding site; other site 226186003996 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226186003997 PYR/PP interface [polypeptide binding]; other site 226186003998 dimer interface [polypeptide binding]; other site 226186003999 TPP binding site [chemical binding]; other site 226186004000 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226186004001 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186004002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186004003 Predicted membrane protein [Function unknown]; Region: COG2364 226186004004 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226186004005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186004006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186004007 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186004008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186004009 nucleotide binding site [chemical binding]; other site 226186004010 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 226186004011 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 226186004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 226186004013 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186004014 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186004015 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186004016 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226186004017 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 226186004018 Domain interface; other site 226186004019 Active site tetrad [active] 226186004020 Peptide binding site; other site 226186004021 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226186004022 protein binding site [polypeptide binding]; other site 226186004023 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 226186004024 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 226186004025 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 226186004026 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226186004027 DNA binding site [nucleotide binding] 226186004028 active site 226186004029 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 226186004030 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186004031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186004032 ligand binding site [chemical binding]; other site 226186004033 flexible hinge region; other site 226186004034 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226186004035 Alginate export; Region: Alginate_exp; pfam13372 226186004036 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226186004037 ResB-like family; Region: ResB; cl09125 226186004038 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 226186004039 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 226186004040 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 226186004041 Domain of unknown function (DUF4625); Region: DUF4625; pfam15418 226186004042 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 226186004043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004044 DsrE/DsrF-like family; Region: DrsE; cl00672 226186004045 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 226186004046 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186004047 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 226186004048 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 226186004049 Protein of unknown function (DUF1062); Region: DUF1062; pfam06353 226186004050 RteC protein; Region: RteC; pfam09357 226186004051 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226186004052 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 226186004053 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 226186004054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186004055 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186004056 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 226186004057 active site 226186004058 catalytic site [active] 226186004059 substrate binding site [chemical binding]; other site 226186004060 mannonate dehydratase; Provisional; Region: PRK03906 226186004061 mannonate dehydratase; Region: uxuA; TIGR00695 226186004062 D-mannonate oxidoreductase; Provisional; Region: PRK08277 226186004063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186004064 NAD(P) binding site [chemical binding]; other site 226186004065 active site 226186004066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226186004067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226186004068 DNA binding site [nucleotide binding] 226186004069 domain linker motif; other site 226186004070 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 226186004071 ligand binding site [chemical binding]; other site 226186004072 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 226186004073 Glycerate kinase family; Region: Gly_kinase; cl00841 226186004074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186004075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186004076 putative substrate translocation pore; other site 226186004077 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186004078 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186004079 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004080 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186004081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004082 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 226186004083 biotin synthase; Region: bioB; TIGR00433 226186004084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186004085 FeS/SAM binding site; other site 226186004086 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 226186004087 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226186004088 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226186004089 inhibitor-cofactor binding pocket; inhibition site 226186004090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186004091 catalytic residue [active] 226186004092 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 226186004093 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226186004094 substrate-cofactor binding pocket; other site 226186004095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186004096 catalytic residue [active] 226186004097 Protein of unknown function (DUF452); Region: DUF452; cl01062 226186004098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226186004099 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 226186004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186004101 S-adenosylmethionine binding site [chemical binding]; other site 226186004102 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 226186004103 AAA domain; Region: AAA_26; pfam13500 226186004104 PAS fold; Region: PAS_4; pfam08448 226186004105 PAS domain; Region: PAS_9; pfam13426 226186004106 PAS fold; Region: PAS_4; pfam08448 226186004107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004108 dimer interface [polypeptide binding]; other site 226186004109 phosphorylation site [posttranslational modification] 226186004110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004111 ATP binding site [chemical binding]; other site 226186004112 Mg2+ binding site [ion binding]; other site 226186004113 G-X-G motif; other site 226186004114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004115 active site 226186004116 phosphorylation site [posttranslational modification] 226186004117 intermolecular recognition site; other site 226186004118 dimerization interface [polypeptide binding]; other site 226186004119 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226186004120 carboxyltransferase (CT) interaction site; other site 226186004121 biotinylation site [posttranslational modification]; other site 226186004122 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 226186004123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186004124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186004125 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226186004126 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 226186004127 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186004128 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186004129 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186004130 Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984 226186004131 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186004132 ligand binding site [chemical binding]; other site 226186004133 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 226186004134 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 226186004135 putative peptide chain release factor H; Region: release_prfH; TIGR03072 226186004136 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 226186004137 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 226186004138 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186004139 catalytic residues [active] 226186004140 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186004141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004142 active site 226186004143 phosphorylation site [posttranslational modification] 226186004144 intermolecular recognition site; other site 226186004145 dimerization interface [polypeptide binding]; other site 226186004146 LytTr DNA-binding domain; Region: LytTR; smart00850 226186004147 Histidine kinase; Region: His_kinase; pfam06580 226186004148 Histidine kinase; Region: His_kinase; pfam06580 226186004149 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 226186004150 DNA binding site [nucleotide binding] 226186004151 dimer interface [polypeptide binding]; other site 226186004152 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004153 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186004154 maltose O-acetyltransferase; Provisional; Region: PRK10092 226186004155 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226186004156 active site 226186004157 substrate binding site [chemical binding]; other site 226186004158 trimer interface [polypeptide binding]; other site 226186004159 CoA binding site [chemical binding]; other site 226186004160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186004161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186004162 Coenzyme A binding pocket [chemical binding]; other site 226186004163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186004164 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186004165 FtsX-like permease family; Region: FtsX; pfam02687 226186004166 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186004167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186004168 FtsX-like permease family; Region: FtsX; pfam02687 226186004169 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186004170 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186004171 Walker A/P-loop; other site 226186004172 ATP binding site [chemical binding]; other site 226186004173 Q-loop/lid; other site 226186004174 ABC transporter signature motif; other site 226186004175 Walker B; other site 226186004176 D-loop; other site 226186004177 H-loop/switch region; other site 226186004178 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186004179 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186004180 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186004181 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186004182 Outer membrane efflux protein; Region: OEP; pfam02321 226186004183 Outer membrane efflux protein; Region: OEP; pfam02321 226186004184 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186004185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004186 active site 226186004187 phosphorylation site [posttranslational modification] 226186004188 intermolecular recognition site; other site 226186004189 dimerization interface [polypeptide binding]; other site 226186004190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186004191 Walker A motif; other site 226186004192 ATP binding site [chemical binding]; other site 226186004193 Walker B motif; other site 226186004194 arginine finger; other site 226186004195 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186004196 PAS domain; Region: PAS_8; pfam13188 226186004197 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226186004198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004199 ATP binding site [chemical binding]; other site 226186004200 Mg2+ binding site [ion binding]; other site 226186004201 G-X-G motif; other site 226186004202 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226186004203 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186004204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186004205 active site 226186004206 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226186004207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186004208 Coenzyme A binding pocket [chemical binding]; other site 226186004209 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 226186004210 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 226186004211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186004212 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 226186004213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186004214 FtsX-like permease family; Region: FtsX; pfam02687 226186004215 aspartate aminotransferase; Provisional; Region: PRK07568 226186004216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186004217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186004218 homodimer interface [polypeptide binding]; other site 226186004219 catalytic residue [active] 226186004220 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 226186004221 substrate binding site [chemical binding]; other site 226186004222 trimer interface [polypeptide binding]; other site 226186004223 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186004224 Mn binding site [ion binding]; other site 226186004225 histidinol-phosphatase; Provisional; Region: PRK07328 226186004226 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 226186004227 active site 226186004228 dimer interface [polypeptide binding]; other site 226186004229 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226186004230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186004231 ABC transporter; Region: ABC_tran_2; pfam12848 226186004232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186004233 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 226186004234 Domain of unknown function (DUF3805); Region: DUF3805; pfam12712 226186004235 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 226186004236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186004237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004238 active site 226186004239 phosphorylation site [posttranslational modification] 226186004240 intermolecular recognition site; other site 226186004241 dimerization interface [polypeptide binding]; other site 226186004242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186004243 DNA binding site [nucleotide binding] 226186004244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004245 dimer interface [polypeptide binding]; other site 226186004246 phosphorylation site [posttranslational modification] 226186004247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004248 ATP binding site [chemical binding]; other site 226186004249 Mg2+ binding site [ion binding]; other site 226186004250 G-X-G motif; other site 226186004251 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186004252 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186004253 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 226186004254 Immunoglobulin domain; Region: Ig; cl11960 226186004255 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 226186004256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004257 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 226186004258 Uncharacterized conserved protein [Function unknown]; Region: COG3391 226186004259 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226186004260 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 226186004261 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 226186004262 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 226186004263 substrate binding site [chemical binding]; other site 226186004264 tetramer interface [polypeptide binding]; other site 226186004265 catalytic residue [active] 226186004266 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 226186004267 Divergent 4Fe-4S mono-cluster; Region: Fer4_19; pfam06902 226186004268 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 226186004269 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 226186004270 Domain of unknown function DUF21; Region: DUF21; pfam01595 226186004271 FOG: CBS domain [General function prediction only]; Region: COG0517 226186004272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226186004273 Transporter associated domain; Region: CorC_HlyC; pfam03471 226186004274 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226186004275 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226186004276 dimer interface [polypeptide binding]; other site 226186004277 ssDNA binding site [nucleotide binding]; other site 226186004278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226186004279 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 226186004280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226186004281 minor groove reading motif; other site 226186004282 helix-hairpin-helix signature motif; other site 226186004283 substrate binding pocket [chemical binding]; other site 226186004284 active site 226186004285 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 226186004286 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 226186004287 DNA binding and oxoG recognition site [nucleotide binding] 226186004288 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 226186004289 dimer interface [polypeptide binding]; other site 226186004290 DNA binding site [nucleotide binding] 226186004291 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 226186004292 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 226186004293 homodimer interface [polypeptide binding]; other site 226186004294 oligonucleotide binding site [chemical binding]; other site 226186004295 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 226186004296 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186004297 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186004298 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186004299 ligand binding site [chemical binding]; other site 226186004300 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186004301 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186004302 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186004303 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186004304 active site 226186004305 catalytic residues [active] 226186004306 DNA binding site [nucleotide binding] 226186004307 Int/Topo IB signature motif; other site 226186004308 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186004309 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186004310 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186004311 ligand binding site [chemical binding]; other site 226186004312 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 226186004313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 226186004314 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186004315 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186004316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186004317 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186004318 active site 226186004319 catalytic residues [active] 226186004320 DNA binding site [nucleotide binding] 226186004321 Int/Topo IB signature motif; other site 226186004322 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 226186004323 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 226186004324 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 226186004325 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186004326 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186004327 ligand binding site [chemical binding]; other site 226186004328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226186004329 fibritin; Provisional; Region: wac; PHA02607 226186004330 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186004331 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186004332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186004333 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186004334 active site 226186004335 catalytic residues [active] 226186004336 DNA binding site [nucleotide binding] 226186004337 Int/Topo IB signature motif; other site 226186004338 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186004339 replicative DNA helicase; Region: DnaB; TIGR00665 226186004340 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 226186004341 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 226186004342 Walker A motif; other site 226186004343 ATP binding site [chemical binding]; other site 226186004344 Walker B motif; other site 226186004345 DNA binding loops [nucleotide binding] 226186004346 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186004347 V-type ATP synthase subunit I; Validated; Region: PRK05771 226186004348 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186004349 amidase catalytic site [active] 226186004350 Zn binding residues [ion binding]; other site 226186004351 substrate binding site [chemical binding]; other site 226186004352 Transcriptional regulator; Region: Rrf2; cl17282 226186004353 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 226186004354 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 226186004355 active site 226186004356 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 226186004357 GtrA-like protein; Region: GtrA; pfam04138 226186004358 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 226186004359 tetramer interfaces [polypeptide binding]; other site 226186004360 binuclear metal-binding site [ion binding]; other site 226186004361 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 226186004362 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226186004364 dimerization interface [polypeptide binding]; other site 226186004365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226186004366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226186004367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004368 ATP binding site [chemical binding]; other site 226186004369 Mg2+ binding site [ion binding]; other site 226186004370 G-X-G motif; other site 226186004371 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004373 active site 226186004374 phosphorylation site [posttranslational modification] 226186004375 intermolecular recognition site; other site 226186004376 dimerization interface [polypeptide binding]; other site 226186004377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186004378 Walker A motif; other site 226186004379 ATP binding site [chemical binding]; other site 226186004380 Walker B motif; other site 226186004381 arginine finger; other site 226186004382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186004383 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186004384 Outer membrane efflux protein; Region: OEP; pfam02321 226186004385 Outer membrane efflux protein; Region: OEP; pfam02321 226186004386 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 226186004387 PAS fold; Region: PAS_3; pfam08447 226186004388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186004389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004390 dimer interface [polypeptide binding]; other site 226186004391 phosphorylation site [posttranslational modification] 226186004392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004393 ATP binding site [chemical binding]; other site 226186004394 Mg2+ binding site [ion binding]; other site 226186004395 G-X-G motif; other site 226186004396 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186004397 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186004398 FtsX-like permease family; Region: FtsX; pfam02687 226186004399 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186004400 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186004401 FtsX-like permease family; Region: FtsX; pfam02687 226186004402 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 226186004403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186004404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186004405 Walker A/P-loop; other site 226186004406 ATP binding site [chemical binding]; other site 226186004407 Q-loop/lid; other site 226186004408 ABC transporter signature motif; other site 226186004409 Walker B; other site 226186004410 D-loop; other site 226186004411 H-loop/switch region; other site 226186004412 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 226186004413 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186004414 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226186004415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186004416 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226186004417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186004418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186004419 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226186004420 cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354 226186004421 active site 226186004422 catalytic motif [active] 226186004423 Zn binding site [ion binding]; other site 226186004424 Domain of unknown function (DUF373); Region: DUF373; cl12079 226186004425 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186004426 Predicted membrane protein [Function unknown]; Region: COG3059 226186004427 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 226186004428 Squalene epoxidase; Region: SE; cl17314 226186004429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186004430 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226186004431 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226186004432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186004433 ABC transporter; Region: ABC_tran_2; pfam12848 226186004434 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 226186004435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186004436 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 226186004437 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 226186004438 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 226186004439 putative NADH binding site [chemical binding]; other site 226186004440 putative active site [active] 226186004441 nudix motif; other site 226186004442 putative metal binding site [ion binding]; other site 226186004443 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186004444 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186004445 ligand binding site [chemical binding]; other site 226186004446 flexible hinge region; other site 226186004447 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 226186004448 Predicted membrane protein [Function unknown]; Region: COG2311 226186004449 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 226186004450 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226186004451 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 226186004452 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 226186004453 active site 226186004454 substrate binding site [chemical binding]; other site 226186004455 metal binding site [ion binding]; metal-binding site 226186004456 Peptidase family C69; Region: Peptidase_C69; pfam03577 226186004457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226186004458 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186004459 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 226186004460 active site 226186004461 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186004462 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004463 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186004464 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004465 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186004466 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186004467 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 226186004468 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 226186004469 hexamer interface [polypeptide binding]; other site 226186004470 ligand binding site [chemical binding]; other site 226186004471 putative active site [active] 226186004472 NAD(P) binding site [chemical binding]; other site 226186004473 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 226186004474 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 226186004475 FMN binding site [chemical binding]; other site 226186004476 substrate binding site [chemical binding]; other site 226186004477 putative catalytic residue [active] 226186004478 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186004479 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186004480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186004481 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186004482 DNA binding residues [nucleotide binding] 226186004483 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 226186004484 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 226186004485 dimerization interface [polypeptide binding]; other site 226186004486 active site 226186004487 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 226186004488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 226186004489 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 226186004490 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 226186004491 Ligand Binding Site [chemical binding]; other site 226186004492 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 226186004493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186004494 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 226186004495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226186004496 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186004497 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186004498 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186004499 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 226186004500 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186004501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186004502 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186004503 DNA binding residues [nucleotide binding] 226186004504 Porin subfamily; Region: Porin_2; pfam02530 226186004505 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 226186004506 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226186004507 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 226186004508 putative ligand binding site [chemical binding]; other site 226186004509 putative NAD binding site [chemical binding]; other site 226186004510 catalytic site [active] 226186004511 Pirin-related protein [General function prediction only]; Region: COG1741 226186004512 Pirin; Region: Pirin; pfam02678 226186004513 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 226186004514 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 226186004515 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 226186004516 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 226186004517 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 226186004518 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 226186004519 dimer interface [polypeptide binding]; other site 226186004520 active site 226186004521 metal binding site [ion binding]; metal-binding site 226186004522 glutathione binding site [chemical binding]; other site 226186004523 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 226186004524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186004525 S-adenosylmethionine binding site [chemical binding]; other site 226186004526 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186004527 catalytic residues [active] 226186004528 Oxygen tolerance; Region: BatD; pfam13584 226186004529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186004530 Coenzyme A binding pocket [chemical binding]; other site 226186004531 YoaP-like; Region: YoaP; pfam14268 226186004532 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 226186004533 metal binding triad [ion binding]; metal-binding site 226186004534 MG2 domain; Region: A2M_N; cl19929 226186004535 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 226186004536 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 226186004537 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 226186004538 G1 box; other site 226186004539 GTP/Mg2+ binding site [chemical binding]; other site 226186004540 Switch I region; other site 226186004541 G2 box; other site 226186004542 G3 box; other site 226186004543 Switch II region; other site 226186004544 G4 box; other site 226186004545 G5 box; other site 226186004546 Nucleoside recognition; Region: Gate; pfam07670 226186004547 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 226186004548 Nucleoside recognition; Region: Gate; pfam07670 226186004549 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 226186004550 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 226186004551 Ligand Binding Site [chemical binding]; other site 226186004552 TilS substrate C-terminal domain; Region: TilS_C; smart00977 226186004553 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 226186004554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186004555 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 226186004556 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 226186004557 transcription termination factor Rho; Provisional; Region: PRK12678 226186004558 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 226186004559 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 226186004560 RNA binding site [nucleotide binding]; other site 226186004561 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 226186004562 multimer interface [polypeptide binding]; other site 226186004563 Walker A motif; other site 226186004564 ATP binding site [chemical binding]; other site 226186004565 Walker B motif; other site 226186004566 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186004567 Sulfatase; Region: Sulfatase; cl19157 226186004568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004569 binding surface 226186004570 TPR motif; other site 226186004571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186004572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004573 dimer interface [polypeptide binding]; other site 226186004574 phosphorylation site [posttranslational modification] 226186004575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004576 ATP binding site [chemical binding]; other site 226186004577 Mg2+ binding site [ion binding]; other site 226186004578 G-X-G motif; other site 226186004579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186004580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186004581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004582 dimer interface [polypeptide binding]; other site 226186004583 phosphorylation site [posttranslational modification] 226186004584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186004585 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186004586 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186004587 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186004588 signal recognition particle protein; Provisional; Region: PRK10867 226186004589 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 226186004590 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226186004591 P loop; other site 226186004592 GTP binding site [chemical binding]; other site 226186004593 Signal peptide binding domain; Region: SRP_SPB; pfam02978 226186004594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186004595 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186004596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186004597 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186004598 ResB-like family; Region: ResB; cl09125 226186004599 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226186004600 Haem-binding domain; Region: Haem_bd; pfam14376 226186004601 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 226186004602 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 226186004603 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 226186004604 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 226186004605 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 226186004606 homodimer interface [polypeptide binding]; other site 226186004607 NADP binding site [chemical binding]; other site 226186004608 substrate binding site [chemical binding]; other site 226186004609 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226186004610 putative active site [active] 226186004611 putative metal binding site [ion binding]; other site 226186004612 PspC domain; Region: PspC; pfam04024 226186004613 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 226186004614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186004615 Walker A motif; other site 226186004616 ATP binding site [chemical binding]; other site 226186004617 Walker B motif; other site 226186004618 arginine finger; other site 226186004619 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 226186004620 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 226186004621 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 226186004622 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 226186004623 metal binding site [ion binding]; metal-binding site 226186004624 dimer interface [polypeptide binding]; other site 226186004625 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226186004626 putative catalytic site [active] 226186004627 putative metal binding site [ion binding]; other site 226186004628 putative phosphate binding site [ion binding]; other site 226186004629 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186004630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186004631 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186004632 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186004633 FecR protein; Region: FecR; pfam04773 226186004634 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186004635 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186004636 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004637 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186004638 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004639 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186004640 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186004641 SusD family; Region: SusD; pfam07980 226186004642 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186004643 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186004644 active site 226186004645 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186004646 Sulfatase; Region: Sulfatase; pfam00884 226186004647 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186004648 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226186004649 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186004650 Sulfatase; Region: Sulfatase; pfam00884 226186004651 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186004652 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186004653 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186004654 sugar binding site [chemical binding]; other site 226186004655 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 226186004656 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186004657 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186004658 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186004659 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186004660 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186004661 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186004662 active site 226186004663 Fn3 associated; Region: Fn3_assoc; pfam13287 226186004664 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186004665 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186004666 Sulfatase; Region: Sulfatase; pfam00884 226186004667 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 226186004668 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186004669 SusD family; Region: SusD; pfam07980 226186004670 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186004671 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004672 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186004673 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004674 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186004675 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186004676 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186004677 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186004678 active site 226186004679 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226186004680 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 226186004681 Substrate binding site; other site 226186004682 metal-binding site 226186004683 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 226186004684 Phosphotransferase enzyme family; Region: APH; pfam01636 226186004685 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 226186004686 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186004687 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186004688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186004689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004690 dimer interface [polypeptide binding]; other site 226186004691 phosphorylation site [posttranslational modification] 226186004692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004693 ATP binding site [chemical binding]; other site 226186004694 Mg2+ binding site [ion binding]; other site 226186004695 G-X-G motif; other site 226186004696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186004697 active site 226186004698 phosphorylation site [posttranslational modification] 226186004699 intermolecular recognition site; other site 226186004700 dimerization interface [polypeptide binding]; other site 226186004701 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186004702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186004703 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186004704 Sulfatase; Region: Sulfatase; pfam00884 226186004705 VirE N-terminal domain; Region: VirE_N; pfam08800 226186004706 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 226186004707 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186004708 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186004709 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186004710 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186004711 amidase catalytic site [active] 226186004712 Zn binding residues [ion binding]; other site 226186004713 substrate binding site [chemical binding]; other site 226186004714 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186004715 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186004716 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226186004717 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 226186004718 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 226186004719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186004720 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186004721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186004722 active site 226186004723 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186004724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186004725 active site 226186004726 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 226186004727 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 226186004728 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 226186004729 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226186004730 substrate binding site; other site 226186004731 dimer interface; other site 226186004732 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226186004733 classical (c) SDRs; Region: SDR_c; cd05233 226186004734 NAD(P) binding site [chemical binding]; other site 226186004735 active site 226186004736 colanic acid exporter; Provisional; Region: PRK10459 226186004737 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186004738 Chain length determinant protein; Region: Wzz; pfam02706 226186004739 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186004740 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 226186004741 SLBB domain; Region: SLBB; pfam10531 226186004742 SLBB domain; Region: SLBB; pfam10531 226186004743 SLBB domain; Region: SLBB; pfam10531 226186004744 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 226186004745 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 226186004746 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186004747 transcriptional activator RfaH; Region: RfaH; TIGR01955 226186004748 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 226186004749 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186004750 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 226186004751 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186004752 active site 226186004753 catalytic residues [active] 226186004754 DNA binding site [nucleotide binding] 226186004755 Int/Topo IB signature motif; other site 226186004756 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226186004757 active site 226186004758 intersubunit interactions; other site 226186004759 catalytic residue [active] 226186004760 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 226186004761 putative active site; other site 226186004762 catalytic residue [active] 226186004763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226186004764 catalytic core [active] 226186004765 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 226186004766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226186004767 putative active site [active] 226186004768 heme pocket [chemical binding]; other site 226186004769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186004770 dimer interface [polypeptide binding]; other site 226186004771 phosphorylation site [posttranslational modification] 226186004772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186004773 ATP binding site [chemical binding]; other site 226186004774 Mg2+ binding site [ion binding]; other site 226186004775 G-X-G motif; other site 226186004776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186004777 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 226186004778 Walker A/P-loop; other site 226186004779 ATP binding site [chemical binding]; other site 226186004780 Q-loop/lid; other site 226186004781 ABC transporter signature motif; other site 226186004782 Walker B; other site 226186004783 D-loop; other site 226186004784 H-loop/switch region; other site 226186004785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186004786 Walker A/P-loop; other site 226186004787 ATP binding site [chemical binding]; other site 226186004788 Q-loop/lid; other site 226186004789 ABC transporter signature motif; other site 226186004790 Walker B; other site 226186004791 D-loop; other site 226186004792 H-loop/switch region; other site 226186004793 pullulanase, type I; Region: pulA_typeI; TIGR02104 226186004794 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 226186004795 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 226186004796 Ca binding site [ion binding]; other site 226186004797 active site 226186004798 catalytic site [active] 226186004799 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 226186004800 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 226186004801 active site 226186004802 putative DNA-binding cleft [nucleotide binding]; other site 226186004803 dimer interface [polypeptide binding]; other site 226186004804 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 226186004805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186004806 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226186004807 active site 226186004808 motif I; other site 226186004809 motif II; other site 226186004810 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186004811 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186004812 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 226186004813 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 226186004814 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 226186004815 dimer interface [polypeptide binding]; other site 226186004816 motif 1; other site 226186004817 active site 226186004818 motif 2; other site 226186004819 motif 3; other site 226186004820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186004821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186004822 putative substrate translocation pore; other site 226186004823 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 226186004824 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226186004825 minor groove reading motif; other site 226186004826 helix-hairpin-helix signature motif; other site 226186004827 substrate binding pocket [chemical binding]; other site 226186004828 active site 226186004829 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 226186004830 substrate binding site [chemical binding]; other site 226186004831 hinge regions; other site 226186004832 ADP binding site [chemical binding]; other site 226186004833 catalytic site [active] 226186004834 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 226186004835 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226186004836 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 226186004837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004838 binding surface 226186004839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186004840 TPR motif; other site 226186004841 TPR repeat; Region: TPR_11; pfam13414 226186004842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004843 binding surface 226186004844 TPR motif; other site 226186004845 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 226186004846 active site 226186004847 dimer interface [polypeptide binding]; other site 226186004848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186004849 active site 226186004850 motif I; other site 226186004851 motif II; other site 226186004852 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226186004853 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 226186004854 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 226186004855 putative FMN binding site [chemical binding]; other site 226186004856 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 226186004857 active site clefts [active] 226186004858 zinc binding site [ion binding]; other site 226186004859 dimer interface [polypeptide binding]; other site 226186004860 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186004861 SusD family; Region: SusD; pfam07980 226186004862 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186004863 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186004864 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186004865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186004866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 226186004867 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 226186004868 dimer interface [polypeptide binding]; other site 226186004869 substrate binding site [chemical binding]; other site 226186004870 metal binding site [ion binding]; metal-binding site 226186004871 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 226186004872 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186004873 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186004874 Lamin Tail Domain; Region: LTD; pfam00932 226186004875 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 226186004876 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 226186004877 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226186004878 carboxyltransferase (CT) interaction site; other site 226186004879 biotinylation site [posttranslational modification]; other site 226186004880 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 226186004881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004882 binding surface 226186004883 TPR repeat; Region: TPR_11; pfam13414 226186004884 TPR motif; other site 226186004885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004886 TPR motif; other site 226186004887 binding surface 226186004888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186004889 binding surface 226186004890 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186004891 TPR motif; other site 226186004892 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 226186004893 intersubunit interface [polypeptide binding]; other site 226186004894 active site 226186004895 zinc binding site [ion binding]; other site 226186004896 Na+ binding site [ion binding]; other site 226186004897 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 226186004898 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186004899 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186004900 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186004901 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186004902 MMPL family; Region: MMPL; cl14618 226186004903 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186004904 Outer membrane efflux protein; Region: OEP; pfam02321 226186004905 Outer membrane efflux protein; Region: OEP; pfam02321 226186004906 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 226186004907 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 226186004908 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 226186004909 active site 226186004910 catalytic residues [active] 226186004911 metal binding site [ion binding]; metal-binding site 226186004912 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226186004913 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226186004914 carboxyltransferase (CT) interaction site; other site 226186004915 biotinylation site [posttranslational modification]; other site 226186004916 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 226186004917 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186004918 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186004919 VirE N-terminal domain; Region: VirE_N; pfam08800 226186004920 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 226186004921 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186004922 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186004923 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186004924 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186004925 amidase catalytic site [active] 226186004926 Zn binding residues [ion binding]; other site 226186004927 substrate binding site [chemical binding]; other site 226186004928 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226186004929 active site 226186004930 NTP binding site [chemical binding]; other site 226186004931 metal binding triad [ion binding]; metal-binding site 226186004932 antibiotic binding site [chemical binding]; other site 226186004933 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226186004934 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186004935 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 226186004936 EpsG family; Region: EpsG; pfam14897 226186004937 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226186004938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186004939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186004940 active site 226186004941 motif I; other site 226186004942 motif II; other site 226186004943 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 226186004944 NeuB family; Region: NeuB; pfam03102 226186004945 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 226186004946 NeuB binding interface [polypeptide binding]; other site 226186004947 putative substrate binding site [chemical binding]; other site 226186004948 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 226186004949 ligand binding site; other site 226186004950 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 226186004951 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186004952 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186004953 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226186004954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226186004955 catalytic residue [active] 226186004956 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226186004957 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 226186004958 PYR/PP interface [polypeptide binding]; other site 226186004959 dimer interface [polypeptide binding]; other site 226186004960 TPP binding site [chemical binding]; other site 226186004961 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 226186004962 TPP-binding site; other site 226186004963 cytidylyltransferase; Region: cytidylyltransferase; cd02170 226186004964 active site 226186004965 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 226186004966 tetramer interface [polypeptide binding]; other site 226186004967 active site 226186004968 Mg2+/Mn2+ binding site [ion binding]; other site 226186004969 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226186004970 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 226186004971 active site 226186004972 metal-binding site 226186004973 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 226186004974 Rho binding site 1 [polypeptide binding]; other site 226186004975 putative Rho binding site 2 [polypeptide binding]; other site 226186004976 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186004977 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 226186004978 SLBB domain; Region: SLBB; pfam10531 226186004979 SLBB domain; Region: SLBB; pfam10531 226186004980 SLBB domain; Region: SLBB; pfam10531 226186004981 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 226186004982 UpxZ family of transcription anti-terminator antagonists; Region: UpxZ; pfam06603 226186004983 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186004984 transcriptional activator RfaH; Region: RfaH; TIGR01955 226186004985 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 226186004986 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186004987 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 226186004988 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186004989 active site 226186004990 catalytic residues [active] 226186004991 DNA binding site [nucleotide binding] 226186004992 Int/Topo IB signature motif; other site 226186004993 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186004994 FecR protein; Region: FecR; pfam04773 226186004995 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186004996 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186004997 DNA binding residues [nucleotide binding] 226186004998 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 226186004999 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 226186005000 G1 box; other site 226186005001 putative GEF interaction site [polypeptide binding]; other site 226186005002 GTP/Mg2+ binding site [chemical binding]; other site 226186005003 Switch I region; other site 226186005004 G2 box; other site 226186005005 G3 box; other site 226186005006 Switch II region; other site 226186005007 G4 box; other site 226186005008 G5 box; other site 226186005009 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 226186005010 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226186005011 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 226186005012 NADP binding site [chemical binding]; other site 226186005013 active site 226186005014 putative substrate binding site [chemical binding]; other site 226186005015 LysE type translocator; Region: LysE; cl00565 226186005016 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 226186005017 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 226186005018 dimerization interface [polypeptide binding]; other site 226186005019 ATP binding site [chemical binding]; other site 226186005020 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 226186005021 dimerization interface [polypeptide binding]; other site 226186005022 ATP binding site [chemical binding]; other site 226186005023 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 226186005024 putative active site [active] 226186005025 catalytic triad [active] 226186005026 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186005027 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186005028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186005029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005030 dimer interface [polypeptide binding]; other site 226186005031 phosphorylation site [posttranslational modification] 226186005032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005033 ATP binding site [chemical binding]; other site 226186005034 Mg2+ binding site [ion binding]; other site 226186005035 G-X-G motif; other site 226186005036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186005037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186005038 active site 226186005039 phosphorylation site [posttranslational modification] 226186005040 intermolecular recognition site; other site 226186005041 dimerization interface [polypeptide binding]; other site 226186005042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186005043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005044 Chromate transporter; Region: Chromate_transp; pfam02417 226186005045 Chromate transporter; Region: Chromate_transp; pfam02417 226186005046 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226186005047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186005048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005049 dimer interface [polypeptide binding]; other site 226186005050 phosphorylation site [posttranslational modification] 226186005051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005052 ATP binding site [chemical binding]; other site 226186005053 Mg2+ binding site [ion binding]; other site 226186005054 G-X-G motif; other site 226186005055 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 226186005056 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226186005057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186005058 ABC transporter signature motif; other site 226186005059 Walker B; other site 226186005060 D-loop; other site 226186005061 H-loop/switch region; other site 226186005062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186005063 Walker A/P-loop; other site 226186005064 ATP binding site [chemical binding]; other site 226186005065 Q-loop/lid; other site 226186005066 ABC transporter signature motif; other site 226186005067 Walker B; other site 226186005068 D-loop; other site 226186005069 H-loop/switch region; other site 226186005070 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186005071 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 226186005072 Carbon starvation protein CstA; Region: CstA; pfam02554 226186005073 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 226186005074 sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827 226186005075 active site 226186005076 catalytic triad [active] 226186005077 oxyanion hole [active] 226186005078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226186005079 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186005080 Interdomain contacts; other site 226186005081 Cytokine receptor motif; other site 226186005082 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226186005083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186005084 Walker A motif; other site 226186005085 ATP binding site [chemical binding]; other site 226186005086 Walker B motif; other site 226186005087 arginine finger; other site 226186005088 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186005089 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 226186005090 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226186005091 dimer interface [polypeptide binding]; other site 226186005092 PYR/PP interface [polypeptide binding]; other site 226186005093 TPP binding site [chemical binding]; other site 226186005094 substrate binding site [chemical binding]; other site 226186005095 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 226186005096 Domain of unknown function; Region: EKR; pfam10371 226186005097 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226186005098 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 226186005099 TPP-binding site [chemical binding]; other site 226186005100 dimer interface [polypeptide binding]; other site 226186005101 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 226186005102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226186005103 dimer interface [polypeptide binding]; other site 226186005104 conserved gate region; other site 226186005105 putative PBP binding loops; other site 226186005106 ABC-ATPase subunit interface; other site 226186005107 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 226186005108 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 226186005109 Walker A/P-loop; other site 226186005110 ATP binding site [chemical binding]; other site 226186005111 Q-loop/lid; other site 226186005112 ABC transporter signature motif; other site 226186005113 Walker B; other site 226186005114 D-loop; other site 226186005115 H-loop/switch region; other site 226186005116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226186005117 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 226186005118 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 226186005119 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226186005120 DNA binding site [nucleotide binding] 226186005121 active site 226186005122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 226186005123 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 226186005124 putative ligand binding site [chemical binding]; other site 226186005125 Cell division protein FtsL; Region: FtsL; cl11433 226186005126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186005127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005128 dimer interface [polypeptide binding]; other site 226186005129 phosphorylation site [posttranslational modification] 226186005130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005131 ATP binding site [chemical binding]; other site 226186005132 Mg2+ binding site [ion binding]; other site 226186005133 G-X-G motif; other site 226186005134 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 226186005135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186005136 active site 226186005137 phosphorylation site [posttranslational modification] 226186005138 intermolecular recognition site; other site 226186005139 dimerization interface [polypeptide binding]; other site 226186005140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186005141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 226186005143 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186005144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186005145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186005146 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 226186005147 putative substrate binding site [chemical binding]; other site 226186005148 putative ATP binding site [chemical binding]; other site 226186005149 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186005150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186005151 putative substrate translocation pore; other site 226186005152 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 226186005153 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226186005154 substrate binding [chemical binding]; other site 226186005155 active site 226186005156 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226186005157 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 226186005158 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 226186005159 active site 226186005160 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186005161 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186005162 SusD family; Region: SusD; pfam07980 226186005163 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186005164 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005165 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186005166 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005167 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 226186005168 active site 226186005169 catalytic residues [active] 226186005170 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 226186005171 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226186005172 substrate binding [chemical binding]; other site 226186005173 active site 226186005174 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226186005175 TROVE domain; Region: TROVE; pfam05731 226186005176 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 226186005177 WYL domain; Region: WYL; pfam13280 226186005178 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186005179 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186005180 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186005181 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186005182 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 226186005183 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186005184 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186005185 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186005186 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 226186005187 ligand binding site [chemical binding]; other site 226186005188 putative catalytic site [active] 226186005189 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186005190 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186005191 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186005192 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005193 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186005194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005195 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 226186005196 metal binding site [ion binding]; metal-binding site 226186005197 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 226186005198 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186005199 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186005200 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186005201 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186005202 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186005203 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186005204 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186005205 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 226186005206 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186005207 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 226186005208 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186005209 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186005210 Probable beta-xylosidase; Provisional; Region: PLN03080 226186005211 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226186005212 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186005213 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186005214 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 226186005215 putative ligand binding site [chemical binding]; other site 226186005216 putative catalytic site [active] 226186005217 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 226186005218 substrate binding site [chemical binding]; other site 226186005219 active site 226186005220 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 226186005221 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 226186005222 active site 226186005223 nucleophile elbow; other site 226186005224 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226186005225 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 226186005226 Ligand Binding Site [chemical binding]; other site 226186005227 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 226186005228 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 226186005229 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 226186005230 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 226186005231 Kelch motif; Region: Kelch_1; pfam01344 226186005232 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 226186005233 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186005234 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186005235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186005236 ligand binding site [chemical binding]; other site 226186005237 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226186005238 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186005239 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186005240 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186005241 active site 226186005242 catalytic residues [active] 226186005243 DNA binding site [nucleotide binding] 226186005244 Int/Topo IB signature motif; other site 226186005245 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186005246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186005247 active site 226186005248 phosphorylation site [posttranslational modification] 226186005249 intermolecular recognition site; other site 226186005250 dimerization interface [polypeptide binding]; other site 226186005251 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186005252 Histidine kinase; Region: His_kinase; pfam06580 226186005253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226186005254 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 226186005255 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186005256 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186005257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005258 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005259 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 226186005260 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186005262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005263 dimer interface [polypeptide binding]; other site 226186005264 phosphorylation site [posttranslational modification] 226186005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005266 ATP binding site [chemical binding]; other site 226186005267 G-X-G motif; other site 226186005268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186005269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005270 dimer interface [polypeptide binding]; other site 226186005271 phosphorylation site [posttranslational modification] 226186005272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186005273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005274 dimer interface [polypeptide binding]; other site 226186005275 phosphorylation site [posttranslational modification] 226186005276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005277 ATP binding site [chemical binding]; other site 226186005278 Mg2+ binding site [ion binding]; other site 226186005279 G-X-G motif; other site 226186005280 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005281 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 226186005282 Ligand binding site [chemical binding]; other site 226186005283 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 226186005284 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 226186005285 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 226186005286 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 226186005287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 226186005288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226186005289 active site 226186005290 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 226186005291 Rhomboid family; Region: Rhomboid; pfam01694 226186005292 HEAT repeats; Region: HEAT_2; pfam13646 226186005293 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 226186005294 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 226186005295 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 226186005296 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 226186005297 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226186005298 HSP70 interaction site [polypeptide binding]; other site 226186005299 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 226186005300 dimer interface [polypeptide binding]; other site 226186005301 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 226186005302 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 226186005303 Sulfatase; Region: Sulfatase; pfam00884 226186005304 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186005305 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 226186005306 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 226186005307 tetramer interface [polypeptide binding]; other site 226186005308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186005309 catalytic residue [active] 226186005310 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 226186005311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186005312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186005313 DNA binding residues [nucleotide binding] 226186005314 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 226186005315 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 226186005316 PYR/PP interface [polypeptide binding]; other site 226186005317 dimer interface [polypeptide binding]; other site 226186005318 tetramer interface [polypeptide binding]; other site 226186005319 TPP binding site [chemical binding]; other site 226186005320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226186005321 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 226186005322 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186005323 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 226186005324 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 226186005325 TPP-binding site [chemical binding]; other site 226186005326 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 226186005327 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 226186005328 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 226186005329 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 226186005330 linker region; other site 226186005331 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 226186005332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186005333 active site 226186005334 DNA binding site [nucleotide binding] 226186005335 Int/Topo IB signature motif; other site 226186005336 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186005337 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186005338 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 226186005339 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 226186005340 ring oligomerisation interface [polypeptide binding]; other site 226186005341 ATP/Mg binding site [chemical binding]; other site 226186005342 stacking interactions; other site 226186005343 hinge regions; other site 226186005344 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 226186005345 oligomerisation interface [polypeptide binding]; other site 226186005346 mobile loop; other site 226186005347 roof hairpin; other site 226186005348 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 226186005349 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 226186005350 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 226186005351 dimer interface [polypeptide binding]; other site 226186005352 ADP-ribose binding site [chemical binding]; other site 226186005353 active site 226186005354 nudix motif; other site 226186005355 metal binding site [ion binding]; metal-binding site 226186005356 GAF domain; Region: GAF_2; pfam13185 226186005357 PAS domain S-box; Region: sensory_box; TIGR00229 226186005358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005359 dimer interface [polypeptide binding]; other site 226186005360 phosphorylation site [posttranslational modification] 226186005361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005362 ATP binding site [chemical binding]; other site 226186005363 Mg2+ binding site [ion binding]; other site 226186005364 G-X-G motif; other site 226186005365 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 226186005366 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226186005367 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 226186005368 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 226186005369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186005370 FeS/SAM binding site; other site 226186005371 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 226186005372 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 226186005373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186005374 FeS/SAM binding site; other site 226186005375 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 226186005376 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 226186005377 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 226186005378 G1 box; other site 226186005379 GTP/Mg2+ binding site [chemical binding]; other site 226186005380 Switch I region; other site 226186005381 G2 box; other site 226186005382 Switch II region; other site 226186005383 G3 box; other site 226186005384 G4 box; other site 226186005385 G5 box; other site 226186005386 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 226186005387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186005388 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186005389 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 226186005390 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 226186005391 dimer interface [polypeptide binding]; other site 226186005392 motif 1; other site 226186005393 active site 226186005394 motif 2; other site 226186005395 motif 3; other site 226186005396 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226186005397 anticodon binding site; other site 226186005398 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 226186005399 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 226186005400 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186005401 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 226186005402 GDP-binding site [chemical binding]; other site 226186005403 ACT binding site; other site 226186005404 IMP binding site; other site 226186005405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226186005406 metal binding site 2 [ion binding]; metal-binding site 226186005407 putative DNA binding helix; other site 226186005408 metal binding site 1 [ion binding]; metal-binding site 226186005409 dimer interface [polypeptide binding]; other site 226186005410 structural Zn2+ binding site [ion binding]; other site 226186005411 A new structural DNA glycosylase; Region: AlkD_like; cd06561 226186005412 active site 226186005413 Peptidase family M49; Region: Peptidase_M49; pfam03571 226186005414 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186005415 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 226186005416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186005417 ATP binding site [chemical binding]; other site 226186005418 putative Mg++ binding site [ion binding]; other site 226186005419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186005420 nucleotide binding region [chemical binding]; other site 226186005421 ATP-binding site [chemical binding]; other site 226186005422 RQC domain; Region: RQC; pfam09382 226186005423 HRDC domain; Region: HRDC; pfam00570 226186005424 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226186005425 TPR repeat; Region: TPR_11; pfam13414 226186005426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186005427 binding surface 226186005428 TPR motif; other site 226186005429 TPR repeat; Region: TPR_11; pfam13414 226186005430 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186005431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186005432 binding surface 226186005433 TPR motif; other site 226186005434 TPR repeat; Region: TPR_11; pfam13414 226186005435 cysteine synthase; Region: PLN02565 226186005436 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226186005437 dimer interface [polypeptide binding]; other site 226186005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186005439 catalytic residue [active] 226186005440 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 226186005441 Sulfatase; Region: Sulfatase; cl19157 226186005442 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 226186005443 active site 226186005444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226186005445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186005446 S-adenosylmethionine binding site [chemical binding]; other site 226186005447 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 226186005448 (R)-citramalate synthase; Provisional; Region: PRK09389 226186005449 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 226186005450 active site 226186005451 catalytic residues [active] 226186005452 metal binding site [ion binding]; metal-binding site 226186005453 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 226186005454 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 226186005455 substrate binding site [chemical binding]; other site 226186005456 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 226186005457 substrate binding site [chemical binding]; other site 226186005458 ligand binding site [chemical binding]; other site 226186005459 2-isopropylmalate synthase; Validated; Region: PRK00915 226186005460 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 226186005461 active site 226186005462 catalytic residues [active] 226186005463 metal binding site [ion binding]; metal-binding site 226186005464 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 226186005465 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226186005466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186005467 S-adenosylmethionine binding site [chemical binding]; other site 226186005468 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 226186005469 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 226186005470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186005471 TPR motif; other site 226186005472 binding surface 226186005473 Integrase core domain; Region: rve; pfam00665 226186005474 Integrase core domain; Region: rve_3; pfam13683 226186005475 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186005476 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186005477 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186005478 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186005479 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226186005480 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186005481 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186005482 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 226186005483 active site 226186005484 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186005485 SusD family; Region: SusD; pfam07980 226186005486 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186005487 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005488 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186005489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005490 FecR protein; Region: FecR; pfam04773 226186005491 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186005492 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186005493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186005494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186005495 DNA binding residues [nucleotide binding] 226186005496 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186005497 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186005498 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 226186005499 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 226186005500 tandem repeat interface [polypeptide binding]; other site 226186005501 oligomer interface [polypeptide binding]; other site 226186005502 active site residues [active] 226186005503 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 226186005504 tandem repeat interface [polypeptide binding]; other site 226186005505 oligomer interface [polypeptide binding]; other site 226186005506 active site residues [active] 226186005507 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 226186005508 purine nucleoside phosphorylase; Provisional; Region: PRK08202 226186005509 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 226186005510 thiamine monophosphate kinase; Provisional; Region: PRK05731 226186005511 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 226186005512 ATP binding site [chemical binding]; other site 226186005513 dimerization interface [polypeptide binding]; other site 226186005514 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186005515 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226186005516 DNA-binding site [nucleotide binding]; DNA binding site 226186005517 RNA-binding motif; other site 226186005518 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226186005519 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186005520 ATP binding site [chemical binding]; other site 226186005521 Mg++ binding site [ion binding]; other site 226186005522 motif III; other site 226186005523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186005524 nucleotide binding region [chemical binding]; other site 226186005525 ATP-binding site [chemical binding]; other site 226186005526 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 226186005527 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 226186005528 FMN binding site [chemical binding]; other site 226186005529 substrate binding site [chemical binding]; other site 226186005530 putative catalytic residue [active] 226186005531 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 226186005532 PAS fold; Region: PAS_3; pfam08447 226186005533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186005534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186005535 DNA binding residues [nucleotide binding] 226186005536 dimerization interface [polypeptide binding]; other site 226186005537 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 226186005538 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 226186005539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186005540 ATP binding site [chemical binding]; other site 226186005541 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226186005542 putative transposase OrfB; Reviewed; Region: PHA02517 226186005543 Integrase core domain; Region: rve; pfam00665 226186005544 Integrase core domain; Region: rve_3; pfam13683 226186005545 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 226186005546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186005547 Transposase [DNA replication, recombination, and repair]; Region: COG5433 226186005548 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 226186005549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186005550 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226186005551 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186005552 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186005553 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 226186005554 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 226186005555 TIGR02757 family protein; Region: TIGR02757 226186005556 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 226186005557 putative efflux protein, MATE family; Region: matE; TIGR00797 226186005558 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 226186005559 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 226186005560 nucleotide binding site [chemical binding]; other site 226186005561 substrate binding site [chemical binding]; other site 226186005562 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226186005563 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 226186005564 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 226186005565 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226186005566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186005567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005568 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226186005569 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 226186005570 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186005571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226186005573 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 226186005574 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 226186005575 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 226186005576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226186005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186005578 NAD(P) binding site [chemical binding]; other site 226186005579 active site 226186005580 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 226186005581 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 226186005582 active site 226186005583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186005584 catalytic residues [active] 226186005585 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 226186005586 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186005587 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186005588 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 226186005589 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226186005590 carboxyltransferase (CT) interaction site; other site 226186005591 biotinylation site [posttranslational modification]; other site 226186005592 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 226186005593 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186005594 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226186005595 arylsulfatase; Provisional; Region: PRK13759 226186005596 Sulfatase; Region: Sulfatase; pfam00884 226186005597 Predicted membrane protein [Function unknown]; Region: COG2855 226186005598 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 226186005599 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 226186005600 active site 226186005601 metal binding site [ion binding]; metal-binding site 226186005602 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226186005603 homodimer interface [polypeptide binding]; other site 226186005604 substrate-cofactor binding pocket; other site 226186005605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186005606 catalytic residue [active] 226186005607 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 226186005608 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 226186005609 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226186005610 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186005611 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186005612 active site 226186005613 DNA binding site [nucleotide binding] 226186005614 Int/Topo IB signature motif; other site 226186005615 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186005616 Int/Topo IB signature motif; other site 226186005617 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186005618 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 226186005619 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 226186005620 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226186005621 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 226186005622 Transposase domain (DUF772); Region: DUF772; pfam05598 226186005623 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186005624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186005625 HEAT repeats; Region: HEAT_2; pfam13646 226186005626 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005627 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005628 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186005629 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 226186005630 Toprim-like; Region: Toprim_2; pfam13155 226186005631 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 226186005632 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186005633 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226186005634 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186005635 P-loop; other site 226186005636 Magnesium ion binding site [ion binding]; other site 226186005637 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186005638 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186005639 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 226186005640 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 226186005641 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226186005642 Walker A/P-loop; other site 226186005643 ATP binding site [chemical binding]; other site 226186005644 Q-loop/lid; other site 226186005645 ABC transporter signature motif; other site 226186005646 Walker B; other site 226186005647 D-loop; other site 226186005648 H-loop/switch region; other site 226186005649 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226186005650 ABC-ATPase subunit interface; other site 226186005651 dimer interface [polypeptide binding]; other site 226186005652 putative PBP binding regions; other site 226186005653 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 226186005654 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 226186005655 putative ligand binding site [chemical binding]; other site 226186005656 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 226186005657 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005658 Glutamine cyclotransferase; Region: Glu_cyclase_2; cl19848 226186005659 Uncharacterized conserved protein [Function unknown]; Region: COG3391 226186005660 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186005661 Receptor L domain; Region: Recep_L_domain; pfam01030 226186005662 polycystin cation channel protein; Region: PCC; TIGR00864 226186005663 Domain of unknown function (DUF4465); Region: DUF4465; pfam14717 226186005664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186005665 active site 226186005666 Int/Topo IB signature motif; other site 226186005667 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186005668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186005669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186005670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186005671 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186005672 Outer membrane efflux protein; Region: OEP; pfam02321 226186005673 Outer membrane efflux protein; Region: OEP; pfam02321 226186005674 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 226186005675 MMPL family; Region: MMPL; cl14618 226186005676 MMPL family; Region: MMPL; cl14618 226186005677 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186005678 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186005679 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186005680 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186005681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186005682 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 226186005683 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226186005684 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226186005685 putative NAD(P) binding site [chemical binding]; other site 226186005686 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 226186005687 glutamate dehydrogenase; Provisional; Region: PRK14031 226186005688 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 226186005689 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 226186005690 NAD(P) binding site [chemical binding]; other site 226186005691 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226186005692 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 226186005693 tetramer interface [polypeptide binding]; other site 226186005694 heme binding pocket [chemical binding]; other site 226186005695 NADPH binding site [chemical binding]; other site 226186005696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186005697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186005698 intermolecular recognition site; other site 226186005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 226186005700 active site 226186005701 phosphorylation site [posttranslational modification] 226186005702 intermolecular recognition site; other site 226186005703 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 226186005704 glutamate dehydrogenase; Provisional; Region: PRK14030 226186005705 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 226186005706 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 226186005707 NAD(P) binding site [chemical binding]; other site 226186005708 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226186005709 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226186005710 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 226186005711 active site 226186005712 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 226186005713 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 226186005714 active site 226186005715 NTP binding site [chemical binding]; other site 226186005716 metal binding triad [ion binding]; metal-binding site 226186005717 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 226186005718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186005719 Zn2+ binding site [ion binding]; other site 226186005720 Mg2+ binding site [ion binding]; other site 226186005721 Protein of unknown function (DUF3843); Region: DUF3843; pfam12954 226186005722 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 226186005723 RuvA N terminal domain; Region: RuvA_N; pfam01330 226186005724 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226186005725 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 226186005726 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 226186005727 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 226186005728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 226186005729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186005730 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 226186005731 Haemolysin-III related; Region: HlyIII; cl03831 226186005732 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186005733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186005734 non-specific DNA binding site [nucleotide binding]; other site 226186005735 salt bridge; other site 226186005736 sequence-specific DNA binding site [nucleotide binding]; other site 226186005737 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 226186005738 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226186005739 active site 226186005740 dimer interface [polypeptide binding]; other site 226186005741 VirE N-terminal domain; Region: VirE_N; pfam08800 226186005742 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186005743 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186005744 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 226186005745 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186005746 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186005747 amidase catalytic site [active] 226186005748 Zn binding residues [ion binding]; other site 226186005749 substrate binding site [chemical binding]; other site 226186005750 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 226186005751 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 226186005752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186005753 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186005754 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 226186005755 ATP cone domain; Region: ATP-cone; pfam03477 226186005756 Class III ribonucleotide reductase; Region: RNR_III; cd01675 226186005757 effector binding site; other site 226186005758 active site 226186005759 Zn binding site [ion binding]; other site 226186005760 glycine loop; other site 226186005761 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 226186005762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186005763 FeS/SAM binding site; other site 226186005764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186005765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186005766 putative substrate translocation pore; other site 226186005767 RIP metalloprotease RseP; Region: TIGR00054 226186005768 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 226186005769 active site 226186005770 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 226186005771 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 226186005772 putative substrate binding region [chemical binding]; other site 226186005773 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 226186005774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 226186005775 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 226186005776 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 226186005777 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226186005778 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186005779 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 226186005780 RimM N-terminal domain; Region: RimM; pfam01782 226186005781 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 226186005782 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226186005783 hinge; other site 226186005784 active site 226186005785 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 226186005786 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 226186005787 Glycoprotease family; Region: Peptidase_M22; pfam00814 226186005788 hypothetical protein; Provisional; Region: PRK11820 226186005789 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 226186005790 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 226186005791 Guanylate kinase; Region: Guanylate_kin; pfam00625 226186005792 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 226186005793 catalytic site [active] 226186005794 G-X2-G-X-G-K; other site 226186005795 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 226186005796 active site 226186005797 (T/H)XGH motif; other site 226186005798 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 226186005799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186005800 Walker A motif; other site 226186005801 ATP binding site [chemical binding]; other site 226186005802 Walker B motif; other site 226186005803 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186005804 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226186005805 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186005806 putative active site [active] 226186005807 putative metal binding site [ion binding]; other site 226186005808 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226186005809 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226186005810 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 226186005811 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 226186005812 NAD binding site [chemical binding]; other site 226186005813 substrate binding site [chemical binding]; other site 226186005814 homodimer interface [polypeptide binding]; other site 226186005815 active site 226186005816 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 226186005817 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 226186005818 substrate binding site; other site 226186005819 tetramer interface; other site 226186005820 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 226186005821 active site 226186005822 metal binding site [ion binding]; metal-binding site 226186005823 homotetramer interface [polypeptide binding]; other site 226186005824 polyphosphate kinase; Provisional; Region: PRK05443 226186005825 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 226186005826 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 226186005827 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 226186005828 domain interface [polypeptide binding]; other site 226186005829 active site 226186005830 catalytic site [active] 226186005831 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 226186005832 domain interface [polypeptide binding]; other site 226186005833 active site 226186005834 catalytic site [active] 226186005835 Phosphate transporter family; Region: PHO4; cl00396 226186005836 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186005837 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 226186005838 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186005839 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 226186005840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186005841 dimer interface [polypeptide binding]; other site 226186005842 phosphorylation site [posttranslational modification] 226186005843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186005844 ATP binding site [chemical binding]; other site 226186005845 Mg2+ binding site [ion binding]; other site 226186005846 G-X-G motif; other site 226186005847 NUMOD4 motif; Region: NUMOD4; pfam07463 226186005848 HNH endonuclease; Region: HNH_3; pfam13392 226186005849 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186005850 amidase catalytic site [active] 226186005851 Zn binding residues [ion binding]; other site 226186005852 substrate binding site [chemical binding]; other site 226186005853 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186005854 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 226186005855 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 226186005856 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 226186005857 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186005858 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186005859 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005860 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 226186005861 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186005862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186005863 active site 226186005864 phosphorylation site [posttranslational modification] 226186005865 intermolecular recognition site; other site 226186005866 dimerization interface [polypeptide binding]; other site 226186005867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226186005868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186005869 ABC transporter; Region: ABC_tran_2; pfam12848 226186005870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186005871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 226186005872 AAA domain; Region: AAA_33; pfam13671 226186005873 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226186005874 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 226186005875 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186005876 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 226186005877 MMPL family; Region: MMPL; cl14618 226186005878 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186005879 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186005880 Outer membrane efflux protein; Region: OEP; pfam02321 226186005881 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 226186005882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186005883 S-adenosylmethionine binding site [chemical binding]; other site 226186005884 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 226186005885 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 226186005886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186005887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186005888 DNA binding residues [nucleotide binding] 226186005889 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 226186005890 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226186005891 putative active site [active] 226186005892 catalytic site [active] 226186005893 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226186005894 putative active site [active] 226186005895 catalytic site [active] 226186005896 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 226186005897 dimerization interface [polypeptide binding]; other site 226186005898 active site 226186005899 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 226186005900 folate binding site [chemical binding]; other site 226186005901 NADP+ binding site [chemical binding]; other site 226186005902 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 226186005903 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 226186005904 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 226186005905 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226186005906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186005907 Coenzyme A binding pocket [chemical binding]; other site 226186005908 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186005909 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186005910 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 226186005911 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226186005912 active site 226186005913 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 226186005914 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226186005915 substrate binding pocket [chemical binding]; other site 226186005916 chain length determination region; other site 226186005917 substrate-Mg2+ binding site; other site 226186005918 catalytic residues [active] 226186005919 aspartate-rich region 1; other site 226186005920 active site lid residues [active] 226186005921 aspartate-rich region 2; other site 226186005922 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186005923 Protein of unknown function (DUF740); Region: DUF740; pfam05340 226186005924 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186005925 cytidylate kinase; Provisional; Region: cmk; PRK00023 226186005926 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 226186005927 AAA domain; Region: AAA_17; pfam13207 226186005928 CMP-binding site; other site 226186005929 The sites determining sugar specificity; other site 226186005930 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 226186005931 Fe-S cluster binding site [ion binding]; other site 226186005932 substrate binding site [chemical binding]; other site 226186005933 catalytic site [active] 226186005934 6-phosphofructokinase; Provisional; Region: PRK03202 226186005935 active site 226186005936 ADP/pyrophosphate binding site [chemical binding]; other site 226186005937 dimerization interface [polypeptide binding]; other site 226186005938 allosteric effector site; other site 226186005939 fructose-1,6-bisphosphate binding site; other site 226186005940 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 226186005941 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226186005942 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 226186005943 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 226186005944 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 226186005945 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186005946 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 226186005947 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186005948 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 226186005949 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 226186005950 putative NAD(P) binding site [chemical binding]; other site 226186005951 active site 226186005952 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 226186005953 active site 226186005954 FMN binding site [chemical binding]; other site 226186005955 substrate binding site [chemical binding]; other site 226186005956 putative catalytic residue [active] 226186005957 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 226186005958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186005959 Coenzyme A binding pocket [chemical binding]; other site 226186005960 citrate synthase; Provisional; Region: PRK14032 226186005961 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 226186005962 oxalacetate binding site [chemical binding]; other site 226186005963 citrylCoA binding site [chemical binding]; other site 226186005964 coenzyme A binding site [chemical binding]; other site 226186005965 catalytic triad [active] 226186005966 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 226186005967 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 226186005968 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 226186005969 substrate binding site [chemical binding]; other site 226186005970 ligand binding site [chemical binding]; other site 226186005971 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 226186005972 substrate binding site [chemical binding]; other site 226186005973 AAA domain; Region: AAA_30; pfam13604 226186005974 AAA domain; Region: AAA_11; pfam13086 226186005975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186005976 ATP binding site [chemical binding]; other site 226186005977 AAA domain; Region: AAA_12; pfam13087 226186005978 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 226186005979 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 226186005980 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 226186005981 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226186005982 active site 226186005983 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226186005984 active site 2 [active] 226186005985 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 226186005986 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 226186005987 putative valine binding site [chemical binding]; other site 226186005988 dimer interface [polypeptide binding]; other site 226186005989 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 226186005990 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 226186005991 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226186005992 PYR/PP interface [polypeptide binding]; other site 226186005993 dimer interface [polypeptide binding]; other site 226186005994 TPP binding site [chemical binding]; other site 226186005995 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226186005996 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 226186005997 TPP-binding site [chemical binding]; other site 226186005998 dimer interface [polypeptide binding]; other site 226186005999 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 226186006000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 226186006001 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 226186006002 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186006003 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186006004 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 226186006005 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226186006006 Tetramer interface [polypeptide binding]; other site 226186006007 active site 226186006008 FMN-binding site [chemical binding]; other site 226186006009 hypothetical protein; Provisional; Region: PRK08201 226186006010 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 226186006011 metal binding site [ion binding]; metal-binding site 226186006012 putative dimer interface [polypeptide binding]; other site 226186006013 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 226186006014 Outer membrane usher protein; Region: Usher; pfam00577 226186006015 DNA topoisomerase III; Provisional; Region: PRK07726 226186006016 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226186006017 active site 226186006018 putative interdomain interaction site [polypeptide binding]; other site 226186006019 putative metal-binding site [ion binding]; other site 226186006020 putative nucleotide binding site [chemical binding]; other site 226186006021 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226186006022 domain I; other site 226186006023 DNA binding groove [nucleotide binding] 226186006024 phosphate binding site [ion binding]; other site 226186006025 domain II; other site 226186006026 domain III; other site 226186006027 nucleotide binding site [chemical binding]; other site 226186006028 catalytic site [active] 226186006029 domain IV; other site 226186006030 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 226186006031 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 226186006032 active site 226186006033 substrate binding site [chemical binding]; other site 226186006034 coenzyme B12 binding site [chemical binding]; other site 226186006035 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 226186006036 B12 binding site [chemical binding]; other site 226186006037 cobalt ligand [ion binding]; other site 226186006038 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 226186006039 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 226186006040 heterodimer interface [polypeptide binding]; other site 226186006041 substrate interaction site [chemical binding]; other site 226186006042 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 226186006043 B12 binding site [chemical binding]; other site 226186006044 putative transporter; Validated; Region: PRK03818 226186006045 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186006046 TrkA-C domain; Region: TrkA_C; pfam02080 226186006047 TrkA-C domain; Region: TrkA_C; pfam02080 226186006048 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 226186006049 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 226186006050 AAA domain; Region: AAA_18; pfam13238 226186006051 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186006052 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006053 Glutamine cyclotransferase; Region: Glu_cyclase_2; cl19848 226186006054 Uncharacterized conserved protein [Function unknown]; Region: COG3391 226186006055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226186006056 DNA-binding site [nucleotide binding]; DNA binding site 226186006057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226186006058 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 226186006059 putative dimerization interface [polypeptide binding]; other site 226186006060 putative ligand binding site [chemical binding]; other site 226186006061 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186006062 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 226186006063 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 226186006064 putative ligand binding site [chemical binding]; other site 226186006065 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226186006066 ABC-ATPase subunit interface; other site 226186006067 dimer interface [polypeptide binding]; other site 226186006068 putative PBP binding regions; other site 226186006069 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226186006070 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226186006071 Walker A/P-loop; other site 226186006072 ATP binding site [chemical binding]; other site 226186006073 Q-loop/lid; other site 226186006074 ABC transporter signature motif; other site 226186006075 Walker B; other site 226186006076 D-loop; other site 226186006077 H-loop/switch region; other site 226186006078 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226186006079 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 226186006080 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186006081 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186006082 ligand binding site [chemical binding]; other site 226186006083 flexible hinge region; other site 226186006084 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226186006085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226186006086 DNA-binding site [nucleotide binding]; DNA binding site 226186006087 UTRA domain; Region: UTRA; pfam07702 226186006088 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 226186006089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186006090 nucleotide binding site [chemical binding]; other site 226186006091 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 226186006092 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186006093 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186006094 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186006095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186006096 putative substrate translocation pore; other site 226186006097 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006098 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006099 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186006100 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006101 SusD family; Region: SusD; pfam07980 226186006102 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cl15687 226186006103 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186006104 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186006105 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 226186006106 active site 226186006107 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 226186006108 Ca binding site [ion binding]; other site 226186006109 substrate binding site [chemical binding]; other site 226186006110 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 226186006111 putative active site [active] 226186006112 catalytic site [active] 226186006113 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 226186006114 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 226186006115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226186006116 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186006117 Outer membrane efflux protein; Region: OEP; pfam02321 226186006118 Outer membrane efflux protein; Region: OEP; pfam02321 226186006119 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186006120 MMPL family; Region: MMPL; cl14618 226186006121 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186006122 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186006123 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186006124 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006126 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186006127 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226186006128 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 226186006129 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 226186006130 dimer interface [polypeptide binding]; other site 226186006131 putative anticodon binding site; other site 226186006132 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 226186006133 motif 1; other site 226186006134 active site 226186006135 motif 2; other site 226186006136 motif 3; other site 226186006137 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 226186006138 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 226186006139 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 226186006140 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 226186006141 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 226186006142 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 226186006143 active site 226186006144 dimer interface [polypeptide binding]; other site 226186006145 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 226186006146 dimer interface [polypeptide binding]; other site 226186006147 active site 226186006148 Phage NinH protein; Region: Phage_NinH; pfam06322 226186006149 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 226186006150 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226186006151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186006152 motif II; other site 226186006153 bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412 226186006154 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226186006155 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226186006156 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 226186006157 dimer interface [polypeptide binding]; other site 226186006158 active site 226186006159 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 226186006160 ligand binding site [chemical binding]; other site 226186006161 active site 226186006162 UGI interface [polypeptide binding]; other site 226186006163 catalytic site [active] 226186006164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186006165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 226186006166 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 226186006167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186006168 Zn2+ binding site [ion binding]; other site 226186006169 Mg2+ binding site [ion binding]; other site 226186006170 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 226186006171 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226186006172 active site 226186006173 metal binding site [ion binding]; metal-binding site 226186006174 Integrase core domain; Region: rve; pfam00665 226186006175 Integrase core domain; Region: rve_3; pfam13683 226186006176 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 226186006177 Sodium Bile acid symporter family; Region: SBF; cl19217 226186006178 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226186006179 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226186006180 active site 226186006181 metal binding site [ion binding]; metal-binding site 226186006182 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 226186006183 mce related protein; Region: MCE; pfam02470 226186006184 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 226186006185 DnaA N-terminal domain; Region: DnaA_N; pfam11638 226186006186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186006187 Walker A motif; other site 226186006188 ATP binding site [chemical binding]; other site 226186006189 Walker B motif; other site 226186006190 arginine finger; other site 226186006191 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 226186006192 DnaA box-binding interface [nucleotide binding]; other site 226186006193 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 226186006194 dimer interface [polypeptide binding]; other site 226186006195 FMN binding site [chemical binding]; other site 226186006196 NADPH bind site [chemical binding]; other site 226186006197 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 226186006198 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 226186006199 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 226186006200 active site 226186006201 dimer interface [polypeptide binding]; other site 226186006202 effector binding site; other site 226186006203 4-alpha-glucanotransferase; Region: PLN02950 226186006204 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 226186006205 starch-binding site 2 [chemical binding]; other site 226186006206 starch-binding site 1 [chemical binding]; other site 226186006207 Disproportionating enzyme 2 (DPE2), N-terminal CBM20 (carbohydrate-binding module, family 20) domain, repeat 2. DPE2 is a transglucosidase that is essential for the cytosolic metabolism of maltose in plant leaves at night. Maltose is an intermediate on...; Region: CBM20_DPE2_repeat2; cd05816 226186006208 starch binding site 2 [chemical binding]; other site 226186006209 starch binding site 1 [chemical binding]; other site 226186006210 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 226186006211 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226186006212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186006213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186006214 dihydroneopterin aldolase; Region: folB; TIGR00525 226186006215 active site 226186006216 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 226186006217 active site 226186006218 dimer interfaces [polypeptide binding]; other site 226186006219 catalytic residues [active] 226186006220 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186006221 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 226186006222 Probable Catalytic site; other site 226186006223 metal-binding site 226186006224 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 226186006225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 226186006226 putative acyl-acceptor binding pocket; other site 226186006227 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 226186006228 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226186006229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186006230 FeS/SAM binding site; other site 226186006231 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 226186006232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226186006233 acyl-activating enzyme (AAE) consensus motif; other site 226186006234 AMP binding site [chemical binding]; other site 226186006235 active site 226186006236 CoA binding site [chemical binding]; other site 226186006237 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226186006238 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226186006239 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186006240 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186006241 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186006242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186006243 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186006244 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 226186006245 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 226186006246 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 226186006247 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 226186006248 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 226186006249 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186006250 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226186006251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186006253 active site 226186006254 phosphorylation site [posttranslational modification] 226186006255 intermolecular recognition site; other site 226186006256 dimerization interface [polypeptide binding]; other site 226186006257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226186006258 DNA binding site [nucleotide binding] 226186006259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186006260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186006261 dimer interface [polypeptide binding]; other site 226186006262 phosphorylation site [posttranslational modification] 226186006263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186006264 ATP binding site [chemical binding]; other site 226186006265 Mg2+ binding site [ion binding]; other site 226186006266 G-X-G motif; other site 226186006267 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 226186006268 elongation factor G; Reviewed; Region: PRK12740 226186006269 G1 box; other site 226186006270 putative GEF interaction site [polypeptide binding]; other site 226186006271 GTP/Mg2+ binding site [chemical binding]; other site 226186006272 Switch I region; other site 226186006273 G2 box; other site 226186006274 G3 box; other site 226186006275 Switch II region; other site 226186006276 G4 box; other site 226186006277 G5 box; other site 226186006278 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 226186006279 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226186006280 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 226186006281 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 226186006282 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 226186006283 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186006284 FeS/SAM binding site; other site 226186006285 HemN C-terminal domain; Region: HemN_C; pfam06969 226186006286 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186006287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186006288 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186006289 DNA binding residues [nucleotide binding] 226186006290 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186006291 FecR protein; Region: FecR; pfam04773 226186006292 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186006293 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006294 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186006295 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006296 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 226186006297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186006298 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226186006299 Walker A/P-loop; other site 226186006300 ATP binding site [chemical binding]; other site 226186006301 Q-loop/lid; other site 226186006302 ABC transporter signature motif; other site 226186006303 Walker B; other site 226186006304 H-loop/switch region; other site 226186006305 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 226186006306 Domain of unknown function (DUF2027); Region: DUF2027; pfam09640 226186006307 Smr domain; Region: Smr; pfam01713 226186006308 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226186006309 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186006310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186006311 motif II; other site 226186006312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186006313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186006314 DNA binding residues [nucleotide binding] 226186006315 dimerization interface [polypeptide binding]; other site 226186006316 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 226186006317 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 226186006318 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186006319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186006320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186006321 DNA binding residues [nucleotide binding] 226186006322 Preprotein translocase subunit; Region: YajC; cl00806 226186006323 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 226186006324 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 226186006325 hinge; other site 226186006326 active site 226186006327 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186006328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186006329 ligand binding site [chemical binding]; other site 226186006330 flexible hinge region; other site 226186006331 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 226186006332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186006333 NAD(P) binding site [chemical binding]; other site 226186006334 active site 226186006335 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 226186006336 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 226186006337 metal binding site [ion binding]; metal-binding site 226186006338 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186006339 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 226186006340 Ricin-type beta-trefoil; Region: RICIN; smart00458 226186006341 putative sugar binding sites [chemical binding]; other site 226186006342 Q-X-W motif; other site 226186006343 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186006344 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186006345 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186006346 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186006347 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186006348 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186006349 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 226186006350 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186006351 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186006352 sugar binding site [chemical binding]; other site 226186006353 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006354 SusD family; Region: SusD; pfam07980 226186006355 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006356 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006357 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006358 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006359 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186006360 tetrathionate reductase subunit C; Provisional; Region: PRK14992 226186006361 FecR protein; Region: FecR; pfam04773 226186006362 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186006363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186006364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186006365 DNA binding residues [nucleotide binding] 226186006366 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186006367 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186006368 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 226186006369 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006370 SusD family; Region: SusD; pfam07980 226186006371 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006372 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006373 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006374 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006375 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186006376 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 226186006377 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 226186006378 septation ring formation regulator EzrA; Provisional; Region: PRK04778 226186006379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226186006380 ABC-ATPase subunit interface; other site 226186006381 dimer interface [polypeptide binding]; other site 226186006382 putative PBP binding regions; other site 226186006383 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 226186006384 Immunity protein 10; Region: Imm10; pfam15562 226186006385 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226186006386 active site 226186006387 NTP binding site [chemical binding]; other site 226186006388 metal binding triad [ion binding]; metal-binding site 226186006389 antibiotic binding site [chemical binding]; other site 226186006390 Protein of unknown function DUF86; Region: DUF86; cl01031 226186006391 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226186006392 Protein of unknown function DUF58; Region: DUF58; pfam01882 226186006393 MoxR-like ATPases [General function prediction only]; Region: COG0714 226186006394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186006395 Walker A motif; other site 226186006396 ATP binding site [chemical binding]; other site 226186006397 Walker B motif; other site 226186006398 arginine finger; other site 226186006399 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 226186006400 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 226186006401 Integral membrane protein DUF95; Region: DUF95; pfam01944 226186006402 Peptidase C10 family; Region: Peptidase_C10; pfam01640 226186006403 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186006404 Peptidase C10 family; Region: Peptidase_C10; pfam01640 226186006405 Peptidase C10 family; Region: Peptidase_C10; pfam01640 226186006406 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 226186006407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186006408 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 226186006409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186006410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186006411 binding surface 226186006412 TPR motif; other site 226186006413 Protein of unknown function (DUF342); Region: DUF342; cl19219 226186006414 RDD family; Region: RDD; pfam06271 226186006415 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186006416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186006417 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006419 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 226186006420 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186006421 catalytic residues [active] 226186006422 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 226186006423 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 226186006424 active site 226186006425 PHP Thumb interface [polypeptide binding]; other site 226186006426 metal binding site [ion binding]; metal-binding site 226186006427 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226186006428 helix loop helix domain; Region: HLH; smart00353 226186006429 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 226186006430 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 226186006431 generic binding surface II; other site 226186006432 generic binding surface I; other site 226186006433 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 226186006434 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 226186006435 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226186006436 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226186006437 nucleoside/Zn binding site; other site 226186006438 dimer interface [polypeptide binding]; other site 226186006439 catalytic motif [active] 226186006440 hypothetical protein; Reviewed; Region: PRK12497 226186006441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 226186006442 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 226186006443 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 226186006444 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 226186006445 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 226186006446 Catalytic dyad [active] 226186006447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186006448 binding surface 226186006449 TPR motif; other site 226186006450 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 226186006451 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 226186006452 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226186006453 putative nucleotide binding site [chemical binding]; other site 226186006454 uridine monophosphate binding site [chemical binding]; other site 226186006455 homohexameric interface [polypeptide binding]; other site 226186006456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186006457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186006458 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186006459 RyR domain; Region: RyR; pfam02026 226186006460 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226186006461 EamA-like transporter family; Region: EamA; pfam00892 226186006462 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 226186006463 hinge region; other site 226186006464 GTPase RsgA; Reviewed; Region: PRK00098 226186006465 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 226186006466 RNA binding site [nucleotide binding]; other site 226186006467 homodimer interface [polypeptide binding]; other site 226186006468 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 226186006469 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226186006470 GTP/Mg2+ binding site [chemical binding]; other site 226186006471 G4 box; other site 226186006472 G5 box; other site 226186006473 G1 box; other site 226186006474 Switch I region; other site 226186006475 G2 box; other site 226186006476 G3 box; other site 226186006477 Switch II region; other site 226186006478 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186006479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186006480 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186006481 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186006482 MMPL family; Region: MMPL; cl14618 226186006483 MMPL family; Region: MMPL; cl14618 226186006484 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186006485 Outer membrane efflux protein; Region: OEP; pfam02321 226186006486 Outer membrane efflux protein; Region: OEP; pfam02321 226186006487 pectate lyase, PelA/Pel-15E family; Region: pec_lyase; TIGR02474 226186006488 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226186006489 fumarate hydratase; Provisional; Region: PRK15389 226186006490 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 226186006491 Fumarase C-terminus; Region: Fumerase_C; pfam05683 226186006492 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226186006493 putative trimer interface [polypeptide binding]; other site 226186006494 putative CoA binding site [chemical binding]; other site 226186006495 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226186006496 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 226186006497 HflX GTPase family; Region: HflX; cd01878 226186006498 G1 box; other site 226186006499 GTP/Mg2+ binding site [chemical binding]; other site 226186006500 Switch I region; other site 226186006501 G2 box; other site 226186006502 G3 box; other site 226186006503 Switch II region; other site 226186006504 G4 box; other site 226186006505 G5 box; other site 226186006506 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 226186006507 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006508 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006509 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006510 Lipid-binding putative hydrolase; Region: Lipid_bd; pfam12888 226186006511 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226186006512 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186006513 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006514 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006515 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006516 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006517 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186006518 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186006519 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226186006520 Int/Topo IB signature motif; other site 226186006521 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006522 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006523 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006524 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006525 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006526 MarC family integral membrane protein; Region: MarC; pfam01914 226186006527 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226186006528 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 226186006529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186006530 motif II; other site 226186006531 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226186006532 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 226186006533 putative SAM binding site [chemical binding]; other site 226186006534 putative homodimer interface [polypeptide binding]; other site 226186006535 ribonuclease E; Reviewed; Region: rne; PRK10811 226186006536 thymidine kinase; Provisional; Region: PRK04296 226186006537 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226186006538 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186006539 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226186006540 Int/Topo IB signature motif; other site 226186006541 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 226186006542 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 226186006543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186006544 active site 226186006545 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 226186006546 Domain of unknown function, B. Theta Gene description (DUF3873); Region: DUF3873; pfam12989 226186006547 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 226186006548 Conjugative transposon protein TraO; Region: TraO; pfam10626 226186006549 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 226186006550 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 226186006551 Protein of unknown function (DUF3989); Region: DUF3989; pfam13150 226186006552 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 226186006553 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 226186006554 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 226186006555 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 226186006556 Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992 226186006557 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186006558 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 226186006559 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226186006560 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186006561 putative active site [active] 226186006562 putative NTP binding site [chemical binding]; other site 226186006563 putative nucleic acid binding site [nucleotide binding]; other site 226186006564 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226186006565 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186006566 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 226186006567 AAA domain; Region: AAA_22; pfam13401 226186006568 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 226186006569 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 226186006570 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 226186006571 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186006572 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226186006573 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186006574 P-loop; other site 226186006575 Magnesium ion binding site [ion binding]; other site 226186006576 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186006577 YWFCY protein; Region: YWFCY; pfam14293 226186006578 AAA-like domain; Region: AAA_10; pfam12846 226186006579 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 226186006580 RteC protein; Region: RteC; pfam09357 226186006581 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006582 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 226186006583 ParB-like nuclease domain; Region: ParB; smart00470 226186006584 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 226186006585 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226186006586 Active Sites [active] 226186006587 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 226186006588 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 226186006589 putative active site [active] 226186006590 putative NTP binding site [chemical binding]; other site 226186006591 putative nucleic acid binding site [nucleotide binding]; other site 226186006592 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186006593 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186006594 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186006595 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186006596 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186006597 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186006598 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186006599 Cupin domain; Region: Cupin_2; cl17218 226186006600 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186006601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006602 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186006603 DNA binding site [nucleotide binding] 226186006604 active site 226186006605 Int/Topo IB signature motif; other site 226186006606 catalytic residues [active] 226186006607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186006608 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 226186006609 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186006610 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226186006611 DNA topoisomerase III; Provisional; Region: PRK07726 226186006612 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226186006613 active site 226186006614 putative interdomain interaction site [polypeptide binding]; other site 226186006615 putative metal-binding site [ion binding]; other site 226186006616 putative nucleotide binding site [chemical binding]; other site 226186006617 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226186006618 domain I; other site 226186006619 DNA binding groove [nucleotide binding] 226186006620 phosphate binding site [ion binding]; other site 226186006621 domain II; other site 226186006622 domain III; other site 226186006623 nucleotide binding site [chemical binding]; other site 226186006624 catalytic site [active] 226186006625 domain IV; other site 226186006626 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226186006627 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 226186006628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186006629 S-adenosylmethionine binding site [chemical binding]; other site 226186006630 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226186006631 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186006632 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 226186006633 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226186006634 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 226186006635 helicase superfamily c-terminal domain; Region: HELICc; smart00490 226186006636 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 226186006637 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 226186006638 AAA domain; Region: AAA_14; pfam13173 226186006639 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226186006640 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186006641 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 226186006642 putative active site [active] 226186006643 putative metal binding site [ion binding]; other site 226186006644 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186006645 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 226186006646 active site 226186006647 metal binding site [ion binding]; metal-binding site 226186006648 interdomain interaction site; other site 226186006649 AAA domain; Region: AAA_25; pfam13481 226186006650 Walker A motif; other site 226186006651 ATP binding site [chemical binding]; other site 226186006652 Walker B motif; other site 226186006653 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186006654 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186006655 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186006656 Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992 226186006657 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006658 Variant SH3 domain; Region: SH3_2; pfam07653 226186006659 Src Homology 3 domain superfamily; Region: SH3; cl17036 226186006660 peptide ligand binding site [polypeptide binding]; other site 226186006661 TfoX C-terminal domain; Region: TfoX_C; pfam04994 226186006662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006663 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006664 CAAX protease self-immunity; Region: Abi; pfam02517 226186006665 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186006666 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226186006667 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 226186006668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186006669 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 226186006670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186006671 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 226186006672 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 226186006673 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 226186006674 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 226186006675 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 226186006676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186006677 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 226186006678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186006679 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 226186006680 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 226186006681 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 226186006682 DNA-sulfur modification-associated; Region: DndB; cl17621 226186006683 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 226186006684 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006685 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_3; cd08975 226186006686 putative DNA binding site [nucleotide binding]; other site 226186006687 catalytic residue [active] 226186006688 formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577 226186006689 putative H2TH interface [polypeptide binding]; other site 226186006690 putative catalytic residues [active] 226186006691 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 226186006692 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226186006693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186006694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186006695 non-specific DNA binding site [nucleotide binding]; other site 226186006696 salt bridge; other site 226186006697 sequence-specific DNA binding site [nucleotide binding]; other site 226186006698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186006699 non-specific DNA binding site [nucleotide binding]; other site 226186006700 salt bridge; other site 226186006701 sequence-specific DNA binding site [nucleotide binding]; other site 226186006702 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006703 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006704 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006706 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186006707 SusD family; Region: SusD; pfam07980 226186006708 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006709 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006710 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006711 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006712 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186006714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186006715 ligand binding site [chemical binding]; other site 226186006716 flexible hinge region; other site 226186006717 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 226186006718 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 226186006719 Domain of unknown function UPF0086; Region: UPF0086; cl00688 226186006720 DinB superfamily; Region: DinB_2; pfam12867 226186006721 DJ-1 family protein; Region: not_thiJ; TIGR01383 226186006722 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 226186006723 conserved cys residue [active] 226186006724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006725 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186006727 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226186006728 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 226186006729 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 226186006730 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 226186006731 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226186006732 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 226186006733 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226186006734 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186006735 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 226186006736 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186006737 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 226186006738 classical (c) SDRs; Region: SDR_c; cd05233 226186006739 NAD(P) binding site [chemical binding]; other site 226186006740 active site 226186006741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186006742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186006743 Coenzyme A binding pocket [chemical binding]; other site 226186006744 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 226186006745 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 226186006746 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226186006747 putative active site [active] 226186006748 catalytic site [active] 226186006749 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226186006750 putative active site [active] 226186006751 catalytic site [active] 226186006752 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186006753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186006754 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186006755 DNA binding residues [nucleotide binding] 226186006756 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186006757 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226186006758 trimer interface [polypeptide binding]; other site 226186006759 active site 226186006760 substrate binding site [chemical binding]; other site 226186006761 CoA binding site [chemical binding]; other site 226186006762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226186006763 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226186006764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226186006765 putative DNA binding site [nucleotide binding]; other site 226186006766 putative Zn2+ binding site [ion binding]; other site 226186006767 AsnC family; Region: AsnC_trans_reg; pfam01037 226186006768 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226186006769 homodimer interface [polypeptide binding]; other site 226186006770 substrate-cofactor binding pocket; other site 226186006771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186006772 catalytic residue [active] 226186006773 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186006774 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226186006775 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186006776 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006777 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186006778 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186006779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186006780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186006781 dimer interface [polypeptide binding]; other site 226186006782 phosphorylation site [posttranslational modification] 226186006783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186006784 ATP binding site [chemical binding]; other site 226186006785 Mg2+ binding site [ion binding]; other site 226186006786 G-X-G motif; other site 226186006787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186006788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186006789 active site 226186006790 phosphorylation site [posttranslational modification] 226186006791 intermolecular recognition site; other site 226186006792 dimerization interface [polypeptide binding]; other site 226186006793 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186006794 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186006795 NHL repeat; Region: NHL; pfam01436 226186006796 NHL repeat; Region: NHL; pfam01436 226186006797 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006798 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006799 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006800 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006801 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186006802 SusD family; Region: SusD; pfam07980 226186006803 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186006804 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 226186006805 Thiamine pyrophosphokinase; Region: TPK; cd07995 226186006806 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 226186006807 active site 226186006808 dimerization interface [polypeptide binding]; other site 226186006809 thiamine binding site [chemical binding]; other site 226186006810 putative transposase OrfB; Reviewed; Region: PHA02517 226186006811 Integrase core domain; Region: rve; pfam00665 226186006812 Integrase core domain; Region: rve_3; pfam13683 226186006813 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 226186006814 threonine synthase; Validated; Region: PRK09225 226186006815 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 226186006816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186006817 catalytic residue [active] 226186006818 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 226186006819 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 226186006820 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 226186006821 putative catalytic residues [active] 226186006822 putative nucleotide binding site [chemical binding]; other site 226186006823 putative aspartate binding site [chemical binding]; other site 226186006824 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 226186006825 dimer interface [polypeptide binding]; other site 226186006826 putative threonine allosteric regulatory site; other site 226186006827 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226186006828 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 226186006829 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226186006830 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 226186006831 homodimer interface [polypeptide binding]; other site 226186006832 active site 226186006833 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 226186006834 AAA domain; Region: AAA_14; pfam13173 226186006835 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186006836 DNA repair protein RadA; Provisional; Region: PRK11823 226186006837 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 226186006838 Walker A motif/ATP binding site; other site 226186006839 ATP binding site [chemical binding]; other site 226186006840 Walker B motif; other site 226186006841 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 226186006842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186006843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186006844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226186006845 DNA binding residues [nucleotide binding] 226186006846 dimerization interface [polypeptide binding]; other site 226186006847 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 226186006848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186006849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 226186006850 Double zinc ribbon; Region: DZR; pfam12773 226186006851 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226186006852 Collagenase; Region: DUF3656; pfam12392 226186006853 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 226186006854 proposed active site lysine [active] 226186006855 conserved cys residue [active] 226186006856 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 226186006857 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 226186006858 aspartate aminotransferase; Provisional; Region: PRK05764 226186006859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186006860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186006861 homodimer interface [polypeptide binding]; other site 226186006862 catalytic residue [active] 226186006863 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 226186006864 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 226186006865 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 226186006866 dimerization interface [polypeptide binding]; other site 226186006867 active site 226186006868 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 226186006869 GMP synthase; Reviewed; Region: guaA; PRK00074 226186006870 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226186006871 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 226186006872 ATP Binding subdomain [chemical binding]; other site 226186006873 Ligand Binding sites [chemical binding]; other site 226186006874 Dimerization subdomain; other site 226186006875 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226186006876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226186006877 dimerization interface [polypeptide binding]; other site 226186006878 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226186006879 PAS domain; Region: PAS; smart00091 226186006880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186006881 dimer interface [polypeptide binding]; other site 226186006882 phosphorylation site [posttranslational modification] 226186006883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186006884 ATP binding site [chemical binding]; other site 226186006885 Mg2+ binding site [ion binding]; other site 226186006886 G-X-G motif; other site 226186006887 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 226186006888 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 226186006889 Ligand Binding Site [chemical binding]; other site 226186006890 potassium-transporting ATPase subunit C; Provisional; Region: PRK14002 226186006891 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 226186006892 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226186006893 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186006894 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 226186006895 putative transposase OrfB; Reviewed; Region: PHA02517 226186006896 Integrase core domain; Region: rve; pfam00665 226186006897 Integrase core domain; Region: rve_3; pfam13683 226186006898 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 226186006899 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186006900 nucleotide binding site [chemical binding]; other site 226186006901 Hexokinase; Region: Hexokinase_2; pfam03727 226186006902 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186006903 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186006904 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186006905 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186006906 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cl15685 226186006907 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186006908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186006909 active site 226186006910 phosphorylation site [posttranslational modification] 226186006911 intermolecular recognition site; other site 226186006912 dimerization interface [polypeptide binding]; other site 226186006913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186006914 Walker A motif; other site 226186006915 ATP binding site [chemical binding]; other site 226186006916 Walker B motif; other site 226186006917 arginine finger; other site 226186006918 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186006919 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226186006920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186006921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186006922 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226186006923 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 226186006924 active site residue [active] 226186006925 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 226186006926 CPxP motif; other site 226186006927 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 226186006928 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186006929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226186006930 putative DNA binding site [nucleotide binding]; other site 226186006931 putative Zn2+ binding site [ion binding]; other site 226186006932 Serine carboxypeptidase S28; Region: Peptidase_S28; cl19554 226186006933 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 226186006934 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186006935 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226186006936 Beta-lactamase; Region: Beta-lactamase; cl17358 226186006937 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226186006938 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 226186006939 active site 226186006940 metal binding site [ion binding]; metal-binding site 226186006941 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226186006942 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186006943 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186006944 ligand binding site [chemical binding]; other site 226186006945 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186006946 DNA binding site [nucleotide binding] 226186006947 active site 226186006948 Int/Topo IB signature motif; other site 226186006949 catalytic residues [active] 226186006950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186006951 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186006952 active site 226186006953 DNA binding site [nucleotide binding] 226186006954 Int/Topo IB signature motif; other site 226186006955 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186006956 Int/Topo IB signature motif; other site 226186006957 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186006958 Peptidase C10 family; Region: Peptidase_C10; pfam01640 226186006959 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226186006960 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186006961 putative active site [active] 226186006962 putative NTP binding site [chemical binding]; other site 226186006963 putative nucleic acid binding site [nucleotide binding]; other site 226186006964 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226186006965 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 226186006966 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 226186006967 Fibronectin type 3 domain; Region: FN3; smart00060 226186006968 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226186006969 active site 226186006970 metal binding site [ion binding]; metal-binding site 226186006971 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 226186006972 putative metal binding site [ion binding]; other site 226186006973 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 226186006974 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 226186006975 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186006976 active site 226186006977 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186006978 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186006979 SusD family; Region: SusD; pfam07980 226186006980 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186006981 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186006982 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186006983 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186006984 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186006985 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186006986 FecR protein; Region: FecR; pfam04773 226186006987 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186006988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186006989 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186006990 DNA binding residues [nucleotide binding] 226186006991 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 226186006992 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186006993 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186006994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186006995 DNA binding site [nucleotide binding] 226186006996 active site 226186006997 Int/Topo IB signature motif; other site 226186006998 Histone H1-like protein Hc1; Region: Hc1; pfam07432 226186006999 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186007000 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186007001 ResB-like family; Region: ResB; cl09125 226186007002 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226186007003 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 226186007004 homotrimer interaction site [polypeptide binding]; other site 226186007005 putative active site [active] 226186007006 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 226186007007 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 226186007008 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 226186007009 Imelysin; Region: Peptidase_M75; pfam09375 226186007010 Imelysin; Region: Peptidase_M75; pfam09375 226186007011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186007012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186007013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186007014 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186007015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186007016 ligand binding site [chemical binding]; other site 226186007017 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226186007018 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186007019 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186007020 active site 226186007021 catalytic residues [active] 226186007022 DNA binding site [nucleotide binding] 226186007023 Int/Topo IB signature motif; other site 226186007024 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 226186007025 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186007026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186007027 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186007028 DNA binding residues [nucleotide binding] 226186007029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186007030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186007031 nucleotide binding site [chemical binding]; other site 226186007032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186007033 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186007034 Walker A/P-loop; other site 226186007035 ATP binding site [chemical binding]; other site 226186007036 Q-loop/lid; other site 226186007037 ABC transporter signature motif; other site 226186007038 Walker B; other site 226186007039 D-loop; other site 226186007040 H-loop/switch region; other site 226186007041 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186007042 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186007043 FtsX-like permease family; Region: FtsX; pfam02687 226186007044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186007045 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226186007046 FtsX-like permease family; Region: FtsX; pfam02687 226186007047 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186007048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186007049 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186007050 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186007051 Outer membrane efflux protein; Region: OEP; pfam02321 226186007052 Outer membrane efflux protein; Region: OEP; pfam02321 226186007053 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 226186007054 methionine sulfoxide reductase B; Provisional; Region: PRK00222 226186007055 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 226186007056 Transglycosylase; Region: Transgly; pfam00912 226186007057 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 226186007058 Family of unknown function (DUF566); Region: DUF566; pfam04484 226186007059 SmpA / OmlA family; Region: SmpA_OmlA; cl19285 226186007060 Domain of unknown function (DUF4476); Region: DUF4476; pfam14771 226186007061 Domain of unknown function (DUF4476); Region: DUF4476; pfam14771 226186007062 Domain of unknown function (DUF4476); Region: DUF4476; pfam14771 226186007063 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 226186007064 S1 domain; Region: S1_2; pfam13509 226186007065 WG containing repeat; Region: WG_beta_rep; pfam14903 226186007066 WYL domain; Region: WYL; pfam13280 226186007067 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 226186007068 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 226186007069 NAD(P) binding site [chemical binding]; other site 226186007070 LDH/MDH dimer interface [polypeptide binding]; other site 226186007071 substrate binding site [chemical binding]; other site 226186007072 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 226186007073 metal binding site 2 [ion binding]; metal-binding site 226186007074 putative DNA binding helix; other site 226186007075 metal binding site 1 [ion binding]; metal-binding site 226186007076 dimer interface [polypeptide binding]; other site 226186007077 structural Zn2+ binding site [ion binding]; other site 226186007078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226186007079 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226186007080 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186007081 Fic family protein [Function unknown]; Region: COG3177 226186007082 Fic/DOC family; Region: Fic; pfam02661 226186007083 Fic/DOC family; Region: Fic; cl00960 226186007084 phosphodiesterase; Provisional; Region: PRK12704 226186007085 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 226186007086 GcpE protein; Region: GcpE; cl19500 226186007087 AIR carboxylase; Region: AIRC; pfam00731 226186007088 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 226186007089 lipoyl attachment site [posttranslational modification]; other site 226186007090 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 226186007091 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 226186007092 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 226186007093 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 226186007094 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 226186007095 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 226186007096 proline aminopeptidase P II; Provisional; Region: PRK10879 226186007097 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 226186007098 active site 226186007099 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 226186007100 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186007101 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 226186007102 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186007103 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 226186007104 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186007105 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 226186007106 active site 226186007107 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 226186007108 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 226186007109 Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112 226186007110 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 226186007111 active site 226186007112 dimer interface [polypeptide binding]; other site 226186007113 IPT/TIG domain; Region: TIG; pfam01833 226186007114 NHL repeat; Region: NHL; pfam01436 226186007115 NHL repeat; Region: NHL; pfam01436 226186007116 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007117 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186007118 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186007119 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186007120 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186007121 SusD family; Region: SusD; pfam07980 226186007122 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186007123 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186007124 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186007125 Rubredoxin [Energy production and conversion]; Region: COG1773 226186007126 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 226186007127 iron binding site [ion binding]; other site 226186007128 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226186007129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186007130 dimer interface [polypeptide binding]; other site 226186007131 phosphorylation site [posttranslational modification] 226186007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186007133 ATP binding site [chemical binding]; other site 226186007134 Mg2+ binding site [ion binding]; other site 226186007135 G-X-G motif; other site 226186007136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226186007137 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226186007138 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226186007139 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226186007140 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226186007141 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226186007142 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226186007143 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 226186007144 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 226186007145 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 226186007146 active site 226186007147 Riboflavin kinase; Region: Flavokinase; smart00904 226186007148 CAAX protease self-immunity; Region: Abi; pfam02517 226186007149 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 226186007150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186007151 non-specific DNA binding site [nucleotide binding]; other site 226186007152 salt bridge; other site 226186007153 sequence-specific DNA binding site [nucleotide binding]; other site 226186007154 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 226186007155 M28 Zn-Peptidases; Region: M28_like_6; cd08656 226186007156 metal binding site [ion binding]; metal-binding site 226186007157 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 226186007158 dimer interface [polypeptide binding]; other site 226186007159 catalytic triad [active] 226186007160 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 226186007161 active site 226186007162 catalytic residues [active] 226186007163 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 226186007164 butyrate kinase; Region: butyr_kinase; TIGR02707 226186007165 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186007166 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186007167 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186007168 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186007169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186007170 non-specific DNA binding site [nucleotide binding]; other site 226186007171 salt bridge; other site 226186007172 sequence-specific DNA binding site [nucleotide binding]; other site 226186007173 Integrase core domain; Region: rve; pfam00665 226186007174 Integrase core domain; Region: rve_3; pfam13683 226186007175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186007176 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186007177 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186007178 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186007179 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007180 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186007181 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186007182 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186007183 FecR protein; Region: FecR; pfam04773 226186007184 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186007185 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186007186 DNA binding residues [nucleotide binding] 226186007187 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 226186007188 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 226186007189 RNase E interface [polypeptide binding]; other site 226186007190 trimer interface [polypeptide binding]; other site 226186007191 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 226186007192 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 226186007193 RNase E interface [polypeptide binding]; other site 226186007194 trimer interface [polypeptide binding]; other site 226186007195 active site 226186007196 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 226186007197 putative nucleic acid binding region [nucleotide binding]; other site 226186007198 G-X-X-G motif; other site 226186007199 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 226186007200 RNA binding site [nucleotide binding]; other site 226186007201 domain interface; other site 226186007202 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 226186007203 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 226186007204 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186007205 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 226186007206 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 226186007207 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 226186007208 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 226186007209 nucleotide binding site/active site [active] 226186007210 HIT family signature motif; other site 226186007211 catalytic residue [active] 226186007212 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186007213 EamA-like transporter family; Region: EamA; pfam00892 226186007214 EamA-like transporter family; Region: EamA; pfam00892 226186007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186007216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186007217 putative substrate translocation pore; other site 226186007218 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186007219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186007220 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186007221 DNA binding residues [nucleotide binding] 226186007222 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 226186007223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186007224 catalytic residue [active] 226186007225 glutaminase; Reviewed; Region: PRK12356 226186007226 Ion channel; Region: Ion_trans_2; pfam07885 226186007227 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 226186007228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186007229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186007230 dimer interface [polypeptide binding]; other site 226186007231 phosphorylation site [posttranslational modification] 226186007232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186007233 ATP binding site [chemical binding]; other site 226186007234 Mg2+ binding site [ion binding]; other site 226186007235 G-X-G motif; other site 226186007236 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186007237 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186007238 Int/Topo IB signature motif; other site 226186007239 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226186007240 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226186007241 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 226186007242 Domain of unknown function (DUF4120); Region: DUF4120; pfam13496 226186007243 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 226186007244 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 226186007245 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 226186007246 Conjugative transposon protein TraO; Region: TraO; pfam10626 226186007247 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 226186007248 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 226186007249 Protein of unknown function (DUF3989); Region: DUF3989; pfam13150 226186007250 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 226186007251 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 226186007252 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 226186007253 Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992 226186007254 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226186007255 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186007256 putative active site [active] 226186007257 putative NTP binding site [chemical binding]; other site 226186007258 putative nucleic acid binding site [nucleotide binding]; other site 226186007259 Type II intron maturase; Region: Intron_maturas2; pfam01348 226186007260 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186007261 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 226186007262 AAA domain; Region: AAA_22; pfam13401 226186007263 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 226186007264 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 226186007265 Domain of unknown function (DUF4122); Region: DUF4122; pfam13498 226186007266 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186007267 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 226186007268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186007269 P-loop; other site 226186007270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226186007271 Magnesium ion binding site [ion binding]; other site 226186007272 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186007273 YWFCY protein; Region: YWFCY; pfam14293 226186007274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226186007275 AAA-like domain; Region: AAA_10; pfam12846 226186007276 Walker A motif; other site 226186007277 ATP binding site [chemical binding]; other site 226186007278 Walker B motif; other site 226186007279 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226186007280 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186007281 putative active site [active] 226186007282 putative NTP binding site [chemical binding]; other site 226186007283 putative nucleic acid binding site [nucleotide binding]; other site 226186007284 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226186007285 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 226186007286 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226186007287 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186007288 putative active site [active] 226186007289 putative NTP binding site [chemical binding]; other site 226186007290 putative nucleic acid binding site [nucleotide binding]; other site 226186007291 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226186007292 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186007293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186007294 active site 226186007295 phosphorylation site [posttranslational modification] 226186007296 intermolecular recognition site; other site 226186007297 dimerization interface [polypeptide binding]; other site 226186007298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186007299 Walker A motif; other site 226186007300 ATP binding site [chemical binding]; other site 226186007301 Walker B motif; other site 226186007302 arginine finger; other site 226186007303 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186007304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186007305 dimer interface [polypeptide binding]; other site 226186007306 phosphorylation site [posttranslational modification] 226186007307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186007308 ATP binding site [chemical binding]; other site 226186007309 Mg2+ binding site [ion binding]; other site 226186007310 G-X-G motif; other site 226186007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186007312 active site 226186007313 phosphorylation site [posttranslational modification] 226186007314 intermolecular recognition site; other site 226186007315 dimerization interface [polypeptide binding]; other site 226186007316 Hpt domain; Region: Hpt; pfam01627 226186007317 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186007318 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186007319 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186007320 sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827 226186007321 active site 226186007322 catalytic triad [active] 226186007323 oxyanion hole [active] 226186007324 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 226186007325 active site 226186007326 catalytic triad [active] 226186007327 oxyanion hole [active] 226186007328 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 226186007329 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 226186007330 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 226186007331 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 226186007332 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 226186007333 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186007334 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186007335 SusD family; Region: SusD; pfam07980 226186007336 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007337 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186007338 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186007339 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186007340 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186007341 NHL repeat; Region: NHL; pfam01436 226186007342 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186007343 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186007344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186007345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186007346 dimer interface [polypeptide binding]; other site 226186007347 phosphorylation site [posttranslational modification] 226186007348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186007349 ATP binding site [chemical binding]; other site 226186007350 Mg2+ binding site [ion binding]; other site 226186007351 G-X-G motif; other site 226186007352 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 226186007353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186007354 active site 226186007355 phosphorylation site [posttranslational modification] 226186007356 intermolecular recognition site; other site 226186007357 dimerization interface [polypeptide binding]; other site 226186007358 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186007359 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186007360 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186007361 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 226186007362 putative catalytic site [active] 226186007363 putative metal binding site [ion binding]; other site 226186007364 putative phosphate binding site [ion binding]; other site 226186007365 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 226186007366 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 226186007367 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186007368 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 226186007369 Int/Topo IB signature motif; other site 226186007370 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186007371 DNA binding site [nucleotide binding] 226186007372 active site 226186007373 Int/Topo IB signature motif; other site 226186007374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186007375 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186007376 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 226186007377 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186007378 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186007379 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186007380 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 226186007381 DNA topoisomerase III; Provisional; Region: PRK07726 226186007382 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226186007383 active site 226186007384 putative interdomain interaction site [polypeptide binding]; other site 226186007385 putative metal-binding site [ion binding]; other site 226186007386 putative nucleotide binding site [chemical binding]; other site 226186007387 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226186007388 domain I; other site 226186007389 DNA binding groove [nucleotide binding] 226186007390 phosphate binding site [ion binding]; other site 226186007391 domain II; other site 226186007392 domain III; other site 226186007393 nucleotide binding site [chemical binding]; other site 226186007394 catalytic site [active] 226186007395 domain IV; other site 226186007396 PRTRC system protein E; Region: PRTRC_E; TIGR03741 226186007397 Prokaryotic Ubiquitin; Region: Prok_Ub; pfam14454 226186007398 Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460 226186007399 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 226186007400 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 226186007401 ATP binding site [chemical binding]; other site 226186007402 substrate interface [chemical binding]; other site 226186007403 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 226186007404 putative metal binding site [ion binding]; other site 226186007405 Uncharacterized conserved protein [Function unknown]; Region: COG1432 226186007406 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 226186007407 MerR family regulatory protein; Region: MerR; pfam00376 226186007408 DNA binding residues [nucleotide binding] 226186007409 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186007410 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186007411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186007412 active site 226186007413 DNA binding site [nucleotide binding] 226186007414 Int/Topo IB signature motif; other site 226186007415 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186007416 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal; Region: Fimbrillin_C; pfam15495 226186007417 Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984 226186007418 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186007419 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186007420 alpha-galactosidase; Region: PLN02808; cl17638 226186007421 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 226186007422 Ca binding site [ion binding]; other site 226186007423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007424 TPR motif; other site 226186007425 binding surface 226186007426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007427 binding surface 226186007428 TPR motif; other site 226186007429 PBP superfamily domain; Region: PBP_like_2; pfam12849 226186007430 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186007431 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186007432 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186007433 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186007434 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 226186007435 putative transposase OrfB; Reviewed; Region: PHA02517 226186007436 Integrase core domain; Region: rve; pfam00665 226186007437 Integrase core domain; Region: rve_3; pfam13683 226186007438 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186007439 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226186007440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226186007441 active site 226186007442 catalytic tetrad [active] 226186007443 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186007444 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186007445 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186007446 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186007447 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 226186007448 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 226186007449 active site 226186007450 catalytic triad [active] 226186007451 oxyanion hole [active] 226186007452 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 226186007453 active site 226186007454 oxyanion hole [active] 226186007455 catalytic triad [active] 226186007456 Uncharacterized protein family (UPF0128); Region: UPF0128; cl00799 226186007457 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186007458 MMPL family; Region: MMPL; cl14618 226186007459 MMPL family; Region: MMPL; cl14618 226186007460 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186007461 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186007462 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186007463 Outer membrane efflux protein; Region: OEP; pfam02321 226186007464 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186007465 Outer membrane efflux protein; Region: OEP; pfam02321 226186007466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186007467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186007468 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 226186007469 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 226186007470 active sites [active] 226186007471 tetramer interface [polypeptide binding]; other site 226186007472 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 226186007473 imidazolonepropionase; Validated; Region: PRK09356 226186007474 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 226186007475 active site 226186007476 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 226186007477 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 226186007478 Formiminotransferase domain; Region: FTCD; pfam02971 226186007479 urocanate hydratase; Provisional; Region: PRK05414 226186007480 MutS domain III; Region: MutS_III; pfam05192 226186007481 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 226186007482 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 226186007483 Walker A/P-loop; other site 226186007484 ATP binding site [chemical binding]; other site 226186007485 Q-loop/lid; other site 226186007486 ABC transporter signature motif; other site 226186007487 Walker B; other site 226186007488 D-loop; other site 226186007489 H-loop/switch region; other site 226186007490 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 226186007491 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 226186007492 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 226186007493 alphaNTD - beta interaction site [polypeptide binding]; other site 226186007494 alphaNTD homodimer interface [polypeptide binding]; other site 226186007495 alphaNTD - beta' interaction site [polypeptide binding]; other site 226186007496 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 226186007497 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 226186007498 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 226186007499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226186007500 RNA binding surface [nucleotide binding]; other site 226186007501 30S ribosomal protein S11; Validated; Region: PRK05309 226186007502 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 226186007503 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 226186007504 rRNA binding site [nucleotide binding]; other site 226186007505 predicted 30S ribosome binding site; other site 226186007506 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226186007507 active site 226186007508 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 226186007509 SecY translocase; Region: SecY; pfam00344 226186007510 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 226186007511 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 226186007512 23S rRNA binding site [nucleotide binding]; other site 226186007513 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 226186007514 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 226186007515 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 226186007516 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 226186007517 5S rRNA interface [nucleotide binding]; other site 226186007518 L27 interface [polypeptide binding]; other site 226186007519 23S rRNA interface [nucleotide binding]; other site 226186007520 L5 interface [polypeptide binding]; other site 226186007521 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 226186007522 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226186007523 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226186007524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 226186007525 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 226186007526 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 226186007527 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 226186007528 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 226186007529 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 226186007530 RNA binding site [nucleotide binding]; other site 226186007531 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 226186007532 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 226186007533 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 226186007534 23S rRNA interface [nucleotide binding]; other site 226186007535 putative translocon interaction site; other site 226186007536 signal recognition particle (SRP54) interaction site; other site 226186007537 L23 interface [polypeptide binding]; other site 226186007538 trigger factor interaction site; other site 226186007539 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 226186007540 23S rRNA interface [nucleotide binding]; other site 226186007541 5S rRNA interface [nucleotide binding]; other site 226186007542 putative antibiotic binding site [chemical binding]; other site 226186007543 L25 interface [polypeptide binding]; other site 226186007544 L27 interface [polypeptide binding]; other site 226186007545 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 226186007546 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 226186007547 G-X-X-G motif; other site 226186007548 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 226186007549 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 226186007550 putative translocon binding site; other site 226186007551 protein-rRNA interface [nucleotide binding]; other site 226186007552 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 226186007553 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 226186007554 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 226186007555 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 226186007556 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 226186007557 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 226186007558 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 226186007559 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 226186007560 elongation factor G; Reviewed; Region: PRK12739 226186007561 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 226186007562 G1 box; other site 226186007563 putative GEF interaction site [polypeptide binding]; other site 226186007564 GTP/Mg2+ binding site [chemical binding]; other site 226186007565 Switch I region; other site 226186007566 G2 box; other site 226186007567 G3 box; other site 226186007568 Switch II region; other site 226186007569 G4 box; other site 226186007570 G5 box; other site 226186007571 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 226186007572 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226186007573 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 226186007574 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 226186007575 30S ribosomal protein S7; Validated; Region: PRK05302 226186007576 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 226186007577 S17 interaction site [polypeptide binding]; other site 226186007578 S8 interaction site; other site 226186007579 16S rRNA interaction site [nucleotide binding]; other site 226186007580 streptomycin interaction site [chemical binding]; other site 226186007581 23S rRNA interaction site [nucleotide binding]; other site 226186007582 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 226186007583 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 226186007584 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 226186007585 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 226186007586 beta and beta' interface [polypeptide binding]; other site 226186007587 beta' and sigma factor interface [polypeptide binding]; other site 226186007588 Zn-binding [ion binding]; other site 226186007589 active site region [active] 226186007590 catalytic site [active] 226186007591 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 226186007592 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 226186007593 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 226186007594 G-loop; other site 226186007595 DNA binding site [nucleotide binding] 226186007596 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 226186007597 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 226186007598 RPB12 interaction site [polypeptide binding]; other site 226186007599 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 226186007600 RPB1 interaction site [polypeptide binding]; other site 226186007601 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 226186007602 RPB10 interaction site [polypeptide binding]; other site 226186007603 RPB11 interaction site [polypeptide binding]; other site 226186007604 RPB3 interaction site [polypeptide binding]; other site 226186007605 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 226186007606 core dimer interface [polypeptide binding]; other site 226186007607 peripheral dimer interface [polypeptide binding]; other site 226186007608 L10 interface [polypeptide binding]; other site 226186007609 L11 interface [polypeptide binding]; other site 226186007610 putative EF-Tu interaction site [polypeptide binding]; other site 226186007611 putative EF-G interaction site [polypeptide binding]; other site 226186007612 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 226186007613 23S rRNA interface [nucleotide binding]; other site 226186007614 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 226186007615 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 226186007616 mRNA/rRNA interface [nucleotide binding]; other site 226186007617 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226186007618 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226186007619 23S rRNA interface [nucleotide binding]; other site 226186007620 L7/L12 interface [polypeptide binding]; other site 226186007621 putative thiostrepton binding site; other site 226186007622 L25 interface [polypeptide binding]; other site 226186007623 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 226186007624 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 226186007625 putative homodimer interface [polypeptide binding]; other site 226186007626 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 226186007627 heterodimer interface [polypeptide binding]; other site 226186007628 homodimer interface [polypeptide binding]; other site 226186007629 elongation factor Tu; Reviewed; Region: PRK12735 226186007630 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 226186007631 G1 box; other site 226186007632 GEF interaction site [polypeptide binding]; other site 226186007633 GTP/Mg2+ binding site [chemical binding]; other site 226186007634 Switch I region; other site 226186007635 G2 box; other site 226186007636 G3 box; other site 226186007637 Switch II region; other site 226186007638 G4 box; other site 226186007639 G5 box; other site 226186007640 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 226186007641 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 226186007642 Antibiotic Binding Site [chemical binding]; other site 226186007643 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 226186007644 30S subunit binding site; other site 226186007645 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226186007646 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226186007647 active site 226186007648 Int/Topo IB signature motif; other site 226186007649 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226186007650 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226186007651 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226186007652 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 226186007653 active site 226186007654 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 226186007655 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 226186007656 trimer interface [polypeptide binding]; other site 226186007657 putative metal binding site [ion binding]; other site 226186007658 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186007659 catalytic residues [active] 226186007660 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186007661 catalytic residues [active] 226186007662 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 226186007663 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 226186007664 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 226186007665 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 226186007666 active site 226186007667 HIGH motif; other site 226186007668 KMSKS motif; other site 226186007669 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 226186007670 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 226186007671 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 226186007672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186007673 Zn2+ binding site [ion binding]; other site 226186007674 Mg2+ binding site [ion binding]; other site 226186007675 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226186007676 active site 226186007677 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 226186007678 primosome assembly protein PriA; Validated; Region: PRK05580 226186007679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186007680 ATP binding site [chemical binding]; other site 226186007681 putative Mg++ binding site [ion binding]; other site 226186007682 helicase superfamily c-terminal domain; Region: HELICc; smart00490 226186007683 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 226186007684 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 226186007685 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 226186007686 Aspartase; Region: Aspartase; cd01357 226186007687 active sites [active] 226186007688 tetramer interface [polypeptide binding]; other site 226186007689 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 226186007690 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 226186007691 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 226186007692 active site 226186007693 homotetramer interface [polypeptide binding]; other site 226186007694 homodimer interface [polypeptide binding]; other site 226186007695 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 226186007696 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 226186007697 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 226186007698 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186007699 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186007700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186007701 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186007702 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226186007703 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226186007704 active site 226186007705 ATP binding site [chemical binding]; other site 226186007706 substrate binding site [chemical binding]; other site 226186007707 activation loop (A-loop); other site 226186007708 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 226186007709 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186007710 phosphopeptide binding site; other site 226186007711 Protein kinase domain; Region: Pkinase; pfam00069 226186007712 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226186007713 active site 226186007714 ATP binding site [chemical binding]; other site 226186007715 substrate binding site [chemical binding]; other site 226186007716 activation loop (A-loop); other site 226186007717 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186007718 phosphopeptide binding site; other site 226186007719 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 226186007720 active site 226186007721 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186007722 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 226186007723 phosphopeptide binding site; other site 226186007724 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186007725 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 226186007726 phosphopeptide binding site; other site 226186007727 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 226186007728 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 226186007729 phosphopeptide binding site; other site 226186007730 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226186007731 VirE N-terminal domain; Region: VirE_N; pfam08800 226186007732 Virulence-associated protein E; Region: VirE; pfam05272 226186007733 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186007734 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 226186007735 G1 box; other site 226186007736 GTP/Mg2+ binding site [chemical binding]; other site 226186007737 G2 box; other site 226186007738 Switch I region; other site 226186007739 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 226186007740 G3 box; other site 226186007741 Switch II region; other site 226186007742 GTP/Mg2+ binding site [chemical binding]; other site 226186007743 G4 box; other site 226186007744 G5 box; other site 226186007745 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186007746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186007747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186007748 DNA binding residues [nucleotide binding] 226186007749 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186007750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186007751 S-adenosylmethionine binding site [chemical binding]; other site 226186007752 Predicted membrane protein [Function unknown]; Region: COG2311 226186007753 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226186007754 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 226186007755 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 226186007756 Substrate binding site; other site 226186007757 AMP-binding domain protein; Validated; Region: PRK08315 226186007758 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 226186007759 acyl-activating enzyme (AAE) consensus motif; other site 226186007760 putative AMP binding site [chemical binding]; other site 226186007761 putative active site [active] 226186007762 putative CoA binding site [chemical binding]; other site 226186007763 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226186007764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186007765 non-specific DNA binding site [nucleotide binding]; other site 226186007766 salt bridge; other site 226186007767 sequence-specific DNA binding site [nucleotide binding]; other site 226186007768 Cupin domain; Region: Cupin_2; pfam07883 226186007769 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 226186007770 16S/18S rRNA binding site [nucleotide binding]; other site 226186007771 S13e-L30e interaction site [polypeptide binding]; other site 226186007772 25S rRNA binding site [nucleotide binding]; other site 226186007773 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 226186007774 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 226186007775 G1 box; other site 226186007776 putative GEF interaction site [polypeptide binding]; other site 226186007777 GTP/Mg2+ binding site [chemical binding]; other site 226186007778 Switch I region; other site 226186007779 G2 box; other site 226186007780 G3 box; other site 226186007781 Switch II region; other site 226186007782 G4 box; other site 226186007783 G5 box; other site 226186007784 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 226186007785 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226186007786 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 226186007787 Chromate transporter; Region: Chromate_transp; pfam02417 226186007788 Chromate transporter; Region: Chromate_transp; pfam02417 226186007789 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 226186007790 active site 226186007791 substrate-binding site [chemical binding]; other site 226186007792 metal-binding site [ion binding] 226186007793 ATP binding site [chemical binding]; other site 226186007794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186007795 active site 226186007796 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186007797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186007798 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226186007799 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 226186007800 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186007801 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186007802 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 226186007803 Outer membrane efflux protein; Region: OEP; pfam02321 226186007804 Outer membrane efflux protein; Region: OEP; pfam02321 226186007805 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 226186007806 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 226186007807 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 226186007808 homotetramer interface [polypeptide binding]; other site 226186007809 ligand binding site [chemical binding]; other site 226186007810 catalytic site [active] 226186007811 NAD binding site [chemical binding]; other site 226186007812 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226186007813 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226186007814 protein binding site [polypeptide binding]; other site 226186007815 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226186007816 Catalytic dyad [active] 226186007817 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 226186007818 adenosine kinase; Provisional; Region: PTZ00247 226186007819 substrate binding site [chemical binding]; other site 226186007820 ATP binding site [chemical binding]; other site 226186007821 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 226186007822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186007823 active site 226186007824 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 226186007825 active site 226186007826 dimerization interface [polypeptide binding]; other site 226186007827 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226186007828 substrate binding site [chemical binding]; other site 226186007829 dimer interface [polypeptide binding]; other site 226186007830 ATP binding site [chemical binding]; other site 226186007831 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226186007832 substrate binding site [chemical binding]; other site 226186007833 dimer interface [polypeptide binding]; other site 226186007834 ATP binding site [chemical binding]; other site 226186007835 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007836 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186007837 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186007838 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186007839 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186007840 SusD family; Region: SusD; pfam07980 226186007841 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226186007842 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 226186007843 active site 226186007844 Ureide permease; Region: Ureide_permease; pfam07168 226186007845 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226186007846 putative catalytic site [active] 226186007847 putative metal binding site [ion binding]; other site 226186007848 putative phosphate binding site [ion binding]; other site 226186007849 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186007850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226186007851 active site 226186007852 metal binding site [ion binding]; metal-binding site 226186007853 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 226186007854 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 226186007855 catalytic residue [active] 226186007856 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 226186007857 catalytic residues [active] 226186007858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186007859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186007860 peroxiredoxin; Region: AhpC; TIGR03137 226186007861 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 226186007862 dimer interface [polypeptide binding]; other site 226186007863 decamer (pentamer of dimers) interface [polypeptide binding]; other site 226186007864 catalytic triad [active] 226186007865 peroxidatic and resolving cysteines [active] 226186007866 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 226186007867 Na binding site [ion binding]; other site 226186007868 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 226186007869 inhibitor site; inhibition site 226186007870 active site 226186007871 dimer interface [polypeptide binding]; other site 226186007872 catalytic residue [active] 226186007873 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 226186007874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226186007875 nudix motif; other site 226186007876 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 226186007877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007878 binding surface 226186007879 TPR motif; other site 226186007880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007881 binding surface 226186007882 TPR motif; other site 226186007883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007884 binding surface 226186007885 TPR motif; other site 226186007886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186007887 binding surface 226186007888 TPR motif; other site 226186007889 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186007890 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186007891 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007892 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186007893 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186007894 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186007895 SusD family; Region: SusD; pfam07980 226186007896 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186007897 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186007898 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186007899 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186007900 SusD family; Region: SusD; pfam07980 226186007901 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186007902 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186007903 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186007904 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186007905 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186007906 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186007907 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 226186007908 active site 226186007909 catalytic residues [active] 226186007910 Glyco_18 domain; Region: Glyco_18; smart00636 226186007911 The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an uncharacterized bacterial member of the family 18 glycosyl hydrolases with homologs found in Flavobacterium, Stigmatella, and Pseudomonas; Region: GH18_3CO4_chitinase; cd06545 226186007912 putative active site [active] 226186007913 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186007914 Two component regulator propeller; Region: Reg_prop; pfam07494 226186007915 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186007916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186007917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186007918 dimer interface [polypeptide binding]; other site 226186007919 phosphorylation site [posttranslational modification] 226186007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186007921 ATP binding site [chemical binding]; other site 226186007922 Mg2+ binding site [ion binding]; other site 226186007923 G-X-G motif; other site 226186007924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186007925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186007926 active site 226186007927 phosphorylation site [posttranslational modification] 226186007928 intermolecular recognition site; other site 226186007929 dimerization interface [polypeptide binding]; other site 226186007930 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186007931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186007932 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 226186007933 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 226186007934 active site 226186007935 interdomain interaction site; other site 226186007936 putative metal-binding site [ion binding]; other site 226186007937 nucleotide binding site [chemical binding]; other site 226186007938 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226186007939 domain I; other site 226186007940 DNA binding groove [nucleotide binding] 226186007941 phosphate binding site [ion binding]; other site 226186007942 domain II; other site 226186007943 domain III; other site 226186007944 nucleotide binding site [chemical binding]; other site 226186007945 catalytic site [active] 226186007946 domain IV; other site 226186007947 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 226186007948 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 226186007949 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 226186007950 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 226186007951 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 226186007952 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 226186007953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226186007954 active site 226186007955 nucleotide binding site [chemical binding]; other site 226186007956 HIGH motif; other site 226186007957 KMSKS motif; other site 226186007958 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226186007959 tRNA binding surface [nucleotide binding]; other site 226186007960 anticodon binding site; other site 226186007961 histone-like DNA-binding protein HU; Region: HU; cd13831 226186007962 dimer interface [polypeptide binding]; other site 226186007963 DNA binding site [nucleotide binding] 226186007964 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 226186007965 Rhomboid family; Region: Rhomboid; pfam01694 226186007966 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226186007967 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 226186007968 putative catalytic site [active] 226186007969 putative metal binding site [ion binding]; other site 226186007970 putative phosphate binding site [ion binding]; other site 226186007971 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 226186007972 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 226186007973 active site 226186007974 Zn binding site [ion binding]; other site 226186007975 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 226186007976 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 226186007977 Protein export membrane protein; Region: SecD_SecF; pfam02355 226186007978 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 226186007979 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 226186007980 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226186007981 dimer interface [polypeptide binding]; other site 226186007982 PYR/PP interface [polypeptide binding]; other site 226186007983 TPP binding site [chemical binding]; other site 226186007984 substrate binding site [chemical binding]; other site 226186007985 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 226186007986 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 226186007987 TPP-binding site [chemical binding]; other site 226186007988 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 226186007989 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226186007990 FtsX-like permease family; Region: FtsX; pfam02687 226186007991 Ribosome-binding factor A; Region: RBFA; pfam02033 226186007992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186007993 S-adenosylmethionine binding site [chemical binding]; other site 226186007994 pyruvate kinase; Provisional; Region: PRK05826 226186007995 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 226186007996 domain interfaces; other site 226186007997 active site 226186007998 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 226186007999 trimer interface [polypeptide binding]; other site 226186008000 active site 226186008001 dimer interface [polypeptide binding]; other site 226186008002 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226186008003 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226186008004 active site 226186008005 Int/Topo IB signature motif; other site 226186008006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186008007 TPR motif; other site 226186008008 TPR repeat; Region: TPR_11; pfam13414 226186008009 binding surface 226186008010 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 226186008011 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186008012 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 226186008013 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 226186008014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186008015 Walker A motif; other site 226186008016 ATP binding site [chemical binding]; other site 226186008017 Walker B motif; other site 226186008018 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 226186008019 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 226186008020 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226186008021 active site 226186008022 catalytic residues [active] 226186008023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008025 ATP binding site [chemical binding]; other site 226186008026 Mg2+ binding site [ion binding]; other site 226186008027 G-X-G motif; other site 226186008028 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 226186008029 Melibiase; Region: Melibiase; pfam02065 226186008030 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 226186008031 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 226186008032 active site 226186008033 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186008034 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226186008035 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186008036 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186008037 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008038 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 226186008039 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008040 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186008041 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186008042 sugar binding site [chemical binding]; other site 226186008043 uncharacterized protein; Provisional; Region: PHA02789 226186008044 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008045 SusD family; Region: SusD; pfam07980 226186008046 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008047 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008048 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008049 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008050 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008051 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008052 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008054 dimer interface [polypeptide binding]; other site 226186008055 phosphorylation site [posttranslational modification] 226186008056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008057 ATP binding site [chemical binding]; other site 226186008058 Mg2+ binding site [ion binding]; other site 226186008059 G-X-G motif; other site 226186008060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186008061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008062 active site 226186008063 phosphorylation site [posttranslational modification] 226186008064 intermolecular recognition site; other site 226186008065 dimerization interface [polypeptide binding]; other site 226186008066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008067 OmpA family; Region: OmpA; pfam00691 226186008068 ligand binding site [chemical binding]; other site 226186008069 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 226186008070 Chain length determinant protein; Region: Wzz; pfam02706 226186008071 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226186008072 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226186008073 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 226186008074 SLBB domain; Region: SLBB; pfam10531 226186008075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008076 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 226186008077 putative ADP-binding pocket [chemical binding]; other site 226186008078 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008079 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186008080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008081 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 226186008082 putative ADP-binding pocket [chemical binding]; other site 226186008083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186008084 active site 226186008085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186008086 Acyltransferase family; Region: Acyl_transf_3; cl19154 226186008087 Core-2/I-Branching enzyme; Region: Branch; pfam02485 226186008088 Core-2/I-Branching enzyme; Region: Branch; pfam02485 226186008089 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 226186008090 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 226186008091 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 226186008092 Ligand binding site; other site 226186008093 metal-binding site 226186008094 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 226186008095 metal-binding site 226186008096 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226186008097 trimer interface [polypeptide binding]; other site 226186008098 active site 226186008099 substrate binding site [chemical binding]; other site 226186008100 CoA binding site [chemical binding]; other site 226186008101 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186008102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186008103 active site 226186008104 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226186008105 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226186008106 trimer interface [polypeptide binding]; other site 226186008107 active site 226186008108 substrate binding site [chemical binding]; other site 226186008109 CoA binding site [chemical binding]; other site 226186008110 colanic acid exporter; Provisional; Region: PRK10459 226186008111 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186008112 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 226186008113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186008114 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226186008115 NAD(P) binding site [chemical binding]; other site 226186008116 active site 226186008117 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226186008118 substrate binding site; other site 226186008119 dimer interface; other site 226186008120 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186008121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186008122 active site 226186008123 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 226186008124 active site 226186008125 substrate binding site [chemical binding]; other site 226186008126 cosubstrate binding site; other site 226186008127 catalytic site [active] 226186008128 WbqC-like protein family; Region: WbqC; pfam08889 226186008129 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226186008130 inhibitor-cofactor binding pocket; inhibition site 226186008131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186008132 catalytic residue [active] 226186008133 Transcription antiterminator [Transcription]; Region: NusG; COG0250 226186008134 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 226186008135 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 226186008136 heterodimer interface [polypeptide binding]; other site 226186008137 homodimer interface [polypeptide binding]; other site 226186008138 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186008139 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 226186008140 putative NAD(P) binding site [chemical binding]; other site 226186008141 active site 226186008142 putative substrate binding site [chemical binding]; other site 226186008143 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 226186008144 Mg++ binding site [ion binding]; other site 226186008145 putative catalytic motif [active] 226186008146 substrate binding site [chemical binding]; other site 226186008147 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186008148 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186008149 active site 226186008150 DNA binding site [nucleotide binding] 226186008151 Int/Topo IB signature motif; other site 226186008152 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 226186008153 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 226186008154 putative ligand binding site [chemical binding]; other site 226186008155 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008156 SusD family; Region: SusD; pfam07980 226186008157 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008158 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008159 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008161 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 226186008162 active site 226186008163 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186008164 NHL repeat; Region: NHL; pfam01436 226186008165 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008166 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008167 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008168 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008169 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008172 dimer interface [polypeptide binding]; other site 226186008173 phosphorylation site [posttranslational modification] 226186008174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008175 ATP binding site [chemical binding]; other site 226186008176 Mg2+ binding site [ion binding]; other site 226186008177 G-X-G motif; other site 226186008178 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 226186008179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008180 active site 226186008181 phosphorylation site [posttranslational modification] 226186008182 intermolecular recognition site; other site 226186008183 dimerization interface [polypeptide binding]; other site 226186008184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008187 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 226186008188 active site 226186008189 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226186008190 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 226186008191 putative substrate binding site [chemical binding]; other site 226186008192 active site 226186008193 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 226186008194 active site 226186008195 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186008196 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008197 SusD family; Region: SusD; pfam07980 226186008198 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008199 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008200 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008201 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008202 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186008203 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 226186008204 putative ligand binding site [chemical binding]; other site 226186008205 putative catalytic site [active] 226186008206 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 226186008207 putative ligand binding site [chemical binding]; other site 226186008208 putative catalytic site [active] 226186008209 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 226186008210 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 226186008211 Protein of unknown function, DUF608; Region: DUF608; pfam04685 226186008212 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 226186008213 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 226186008214 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186008215 trimer interface [polypeptide binding]; other site 226186008216 substrate binding site [chemical binding]; other site 226186008217 Mn binding site [ion binding]; other site 226186008218 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186008219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008220 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008222 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186008223 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 226186008224 active site 226186008225 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186008226 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008227 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226186008228 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008229 Sulfatase; Region: Sulfatase; cl19157 226186008230 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 226186008231 putative active site [active] 226186008232 putative metal binding site [ion binding]; other site 226186008233 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186008234 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 226186008235 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186008236 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008237 SusD family; Region: SusD; pfam07980 226186008238 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008239 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008240 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008241 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008242 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186008243 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008244 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008245 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186008246 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008247 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008248 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008251 dimer interface [polypeptide binding]; other site 226186008252 phosphorylation site [posttranslational modification] 226186008253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008254 ATP binding site [chemical binding]; other site 226186008255 Mg2+ binding site [ion binding]; other site 226186008256 G-X-G motif; other site 226186008257 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 226186008258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008259 active site 226186008260 phosphorylation site [posttranslational modification] 226186008261 intermolecular recognition site; other site 226186008262 dimerization interface [polypeptide binding]; other site 226186008263 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186008264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008265 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 226186008266 CoA binding domain; Region: CoA_binding_2; pfam13380 226186008267 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 226186008268 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 226186008269 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186008270 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 226186008271 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 226186008272 JAB-like toxin 1; Region: Toxin-JAB1; pfam15659 226186008273 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186008274 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186008275 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 226186008276 Predicted transcriptional regulator [Transcription]; Region: COG2932 226186008277 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226186008278 Catalytic site [active] 226186008279 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 226186008280 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226186008281 active site 226186008282 HIGH motif; other site 226186008283 KMSKS motif; other site 226186008284 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226186008285 tRNA binding surface [nucleotide binding]; other site 226186008286 anticodon binding site; other site 226186008287 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 226186008288 dimer interface [polypeptide binding]; other site 226186008289 putative tRNA-binding site [nucleotide binding]; other site 226186008290 colanic acid exporter; Provisional; Region: PRK10459 226186008291 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 226186008292 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 226186008293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008294 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186008295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008297 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226186008298 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186008299 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186008300 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186008301 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 226186008302 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186008303 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186008304 MMPL family; Region: MMPL; cl14618 226186008305 MMPL family; Region: MMPL; cl14618 226186008306 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186008307 Outer membrane efflux protein; Region: OEP; pfam02321 226186008308 Outer membrane efflux protein; Region: OEP; pfam02321 226186008309 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 226186008310 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 226186008311 putative trimer interface [polypeptide binding]; other site 226186008312 putative CoA binding site [chemical binding]; other site 226186008313 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 226186008314 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 226186008315 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226186008316 active site 226186008317 homodimer interface [polypeptide binding]; other site 226186008318 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 226186008319 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 226186008320 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226186008321 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226186008322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186008323 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 226186008324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186008325 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 226186008326 metal-binding site 226186008327 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186008328 PA14 domain; Region: PA14; pfam07691 226186008329 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186008330 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186008331 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186008332 intermolecular salt bridges; other site 226186008333 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008334 SusD family; Region: SusD; pfam07980 226186008335 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008336 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008337 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008338 rhamnose-proton symporter; Provisional; Region: PRK13499 226186008339 Pyruvate formate lyase; Region: PFL; pfam02901 226186008340 Glycine radical; Region: Gly_radical; cl19199 226186008341 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 226186008342 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 226186008343 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226186008344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186008345 FeS/SAM binding site; other site 226186008346 transcriptional activator RhaR; Provisional; Region: PRK13501 226186008347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186008348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008349 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 226186008350 active site 226186008351 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226186008352 active site 226186008353 catalytic triad [active] 226186008354 oxyanion hole [active] 226186008355 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186008356 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 226186008357 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 226186008358 substrate binding site [chemical binding]; other site 226186008359 catalytic residues [active] 226186008360 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008361 SusD family; Region: SusD; pfam07980 226186008362 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008363 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008364 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008365 beta-D-glucuronidase; Provisional; Region: PRK10150 226186008366 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008367 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008368 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186008369 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 226186008370 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186008371 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008372 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008375 dimer interface [polypeptide binding]; other site 226186008376 phosphorylation site [posttranslational modification] 226186008377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008378 ATP binding site [chemical binding]; other site 226186008379 Mg2+ binding site [ion binding]; other site 226186008380 G-X-G motif; other site 226186008381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186008382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008383 active site 226186008384 phosphorylation site [posttranslational modification] 226186008385 intermolecular recognition site; other site 226186008386 dimerization interface [polypeptide binding]; other site 226186008387 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186008388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226186008390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186008391 S-adenosylmethionine binding site [chemical binding]; other site 226186008392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008395 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 226186008396 NAD+ binding site [chemical binding]; other site 226186008397 substrate binding site [chemical binding]; other site 226186008398 Zn binding site [ion binding]; other site 226186008399 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 226186008400 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 226186008401 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226186008402 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 226186008403 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 226186008404 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226186008405 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 226186008406 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 226186008407 putative DNA binding site [nucleotide binding]; other site 226186008408 putative Zn2+ binding site [ion binding]; other site 226186008409 Domain of unknown function (DUF4491); Region: DUF4491; pfam14898 226186008410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186008411 active site 226186008412 DNA binding site [nucleotide binding] 226186008413 Int/Topo IB signature motif; other site 226186008414 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186008415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 226186008416 Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987 226186008417 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226186008418 MPN+ (JAMM) motif; other site 226186008419 Zinc-binding site [ion binding]; other site 226186008420 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186008421 active site 226186008422 DNA binding site [nucleotide binding] 226186008423 Int/Topo IB signature motif; other site 226186008424 Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1 226186008425 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226186008426 active site 226186008427 catalytic residues [active] 226186008428 DNA binding site [nucleotide binding] 226186008429 Int/Topo IB signature motif; other site 226186008430 Virulence-associated protein E; Region: VirE; pfam05272 226186008431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226186008432 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 226186008433 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186008434 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 226186008435 Vpu protein; Region: Vpu; pfam00558 226186008436 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 226186008437 Part of AAA domain; Region: AAA_19; pfam13245 226186008438 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 226186008439 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226186008440 T5orf172 domain; Region: T5orf172; pfam10544 226186008441 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 226186008442 Divergent AAA domain; Region: AAA_4; pfam04326 226186008443 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186008444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186008445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186008446 non-specific DNA binding site [nucleotide binding]; other site 226186008447 salt bridge; other site 226186008448 sequence-specific DNA binding site [nucleotide binding]; other site 226186008449 TIR domain; Region: TIR_2; pfam13676 226186008450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186008451 binding surface 226186008452 TPR motif; other site 226186008453 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 226186008454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226186008455 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186008456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 226186008457 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186008458 PA14 domain; Region: PA14; pfam07691 226186008459 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186008460 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186008461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186008462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186008463 DNA binding residues [nucleotide binding] 226186008464 FecR protein; Region: FecR; pfam04773 226186008465 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186008466 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008467 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008468 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008469 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008470 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008471 SusD family; Region: SusD; pfam07980 226186008472 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186008473 Interdomain contacts; other site 226186008474 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186008475 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186008476 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186008477 sugar binding site [chemical binding]; other site 226186008478 Peptidase M60-like family; Region: M60-like; pfam13402 226186008479 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186008480 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 226186008481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 226186008482 N-terminal plug; other site 226186008483 ligand-binding site [chemical binding]; other site 226186008484 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 226186008485 active site 226186008486 metal binding site [ion binding]; metal-binding site 226186008487 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186008488 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226186008489 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 226186008490 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 226186008491 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 226186008492 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 226186008493 Sulfatase; Region: Sulfatase; cl19157 226186008494 Sulfatase; Region: Sulfatase; cl19157 226186008495 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008496 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008498 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008499 SusD family; Region: SusD; pfam07980 226186008500 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 226186008501 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186008502 active site 226186008503 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 226186008504 Na binding site [ion binding]; other site 226186008505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226186008506 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186008507 active site 226186008508 metal binding site [ion binding]; metal-binding site 226186008509 PQQ-like domain; Region: PQQ_2; pfam13360 226186008510 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 226186008511 active site 226186008512 Trp docking motif [polypeptide binding]; other site 226186008513 PQQ-like domain; Region: PQQ_2; pfam13360 226186008514 ORF6N domain; Region: ORF6N; pfam10543 226186008515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186008516 Coenzyme A binding pocket [chemical binding]; other site 226186008517 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 226186008518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008519 ATP binding site [chemical binding]; other site 226186008520 Mg2+ binding site [ion binding]; other site 226186008521 G-X-G motif; other site 226186008522 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 226186008523 ATP binding site [chemical binding]; other site 226186008524 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 226186008525 active site 226186008526 putative metal-binding site [ion binding]; other site 226186008527 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226186008528 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 226186008529 active site 226186008530 nucleotide binding site [chemical binding]; other site 226186008531 HIGH motif; other site 226186008532 KMSKS motif; other site 226186008533 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226186008534 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226186008535 protein binding site [polypeptide binding]; other site 226186008536 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226186008537 Catalytic dyad [active] 226186008538 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008539 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186008540 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186008541 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186008542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186008543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186008544 DNA binding residues [nucleotide binding] 226186008545 FecR protein; Region: FecR; pfam04773 226186008546 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 226186008547 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186008548 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 226186008549 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 226186008550 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 226186008551 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186008552 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008553 SusD family; Region: SusD; pfam07980 226186008554 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008555 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008556 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008557 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008558 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186008559 MG2 domain; Region: A2M_N; cl19929 226186008560 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008561 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008562 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008565 dimer interface [polypeptide binding]; other site 226186008566 phosphorylation site [posttranslational modification] 226186008567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008568 ATP binding site [chemical binding]; other site 226186008569 Mg2+ binding site [ion binding]; other site 226186008570 G-X-G motif; other site 226186008571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008573 active site 226186008574 phosphorylation site [posttranslational modification] 226186008575 intermolecular recognition site; other site 226186008576 dimerization interface [polypeptide binding]; other site 226186008577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008579 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186008580 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186008581 active site 226186008582 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008583 Sulfatase; Region: Sulfatase; pfam00884 226186008584 Uncharacterized conserved protein [Function unknown]; Region: COG3379 226186008585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008587 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 226186008588 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 226186008589 putative Iron-sulfur protein interface [polypeptide binding]; other site 226186008590 proximal heme binding site [chemical binding]; other site 226186008591 distal heme binding site [chemical binding]; other site 226186008592 putative dimer interface [polypeptide binding]; other site 226186008593 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 226186008594 L-aspartate oxidase; Provisional; Region: PRK06175 226186008595 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 226186008596 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 226186008597 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 226186008598 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186008599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008600 Sulfatase; Region: Sulfatase; pfam00884 226186008601 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 226186008602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008603 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186008604 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186008605 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186008606 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 226186008607 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186008608 ligand binding site [chemical binding]; other site 226186008609 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186008610 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186008611 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186008612 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 226186008613 alpha-galactosidase; Region: PLN02229 226186008614 Putative Ig domain; Region: He_PIG; pfam05345 226186008615 alpha-galactosidase; Region: PLN02808; cl17638 226186008616 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186008617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186008618 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186008619 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226186008620 catalytic residues [active] 226186008621 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 226186008622 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 226186008623 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226186008624 active site 226186008625 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226186008626 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 226186008627 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226186008628 FMN binding site [chemical binding]; other site 226186008629 active site 226186008630 catalytic residues [active] 226186008631 substrate binding site [chemical binding]; other site 226186008632 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 226186008633 active site 226186008634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186008635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186008636 NAD(P) binding site [chemical binding]; other site 226186008637 active site 226186008638 ribonuclease R; Region: RNase_R; TIGR02063 226186008639 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 226186008640 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226186008641 RNB domain; Region: RNB; pfam00773 226186008642 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 226186008643 RNA binding site [nucleotide binding]; other site 226186008644 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 226186008645 CotH protein; Region: CotH; pfam08757 226186008646 cysteine synthase; Region: PLN02565 226186008647 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226186008648 dimer interface [polypeptide binding]; other site 226186008649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186008650 catalytic residue [active] 226186008651 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 226186008652 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 226186008653 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226186008654 substrate binding [chemical binding]; other site 226186008655 active site 226186008656 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226186008657 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 226186008658 AAA domain; Region: AAA_14; pfam13173 226186008659 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186008660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 226186008661 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186008662 substrate binding pocket [chemical binding]; other site 226186008663 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186008664 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186008665 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186008666 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 226186008667 catalytic site [active] 226186008668 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 226186008669 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186008670 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186008671 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 226186008672 active site 226186008673 catalytic site [active] 226186008674 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 226186008675 SusE outer membrane protein; Region: SusE; pfam14292 226186008676 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 226186008677 starch binding site [chemical binding]; other site 226186008678 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008679 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008680 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008681 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008682 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008683 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008684 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008685 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008686 Sulfatase; Region: Sulfatase; pfam00884 226186008687 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 226186008688 active site 226186008689 arylsulfatase; Provisional; Region: PRK13759 226186008690 Sulfatase; Region: Sulfatase; pfam00884 226186008691 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 226186008692 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008693 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008696 dimer interface [polypeptide binding]; other site 226186008697 phosphorylation site [posttranslational modification] 226186008698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008699 ATP binding site [chemical binding]; other site 226186008700 Mg2+ binding site [ion binding]; other site 226186008701 G-X-G motif; other site 226186008702 transcriptional regulator NarL; Provisional; Region: PRK10651 226186008703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008704 active site 226186008705 phosphorylation site [posttranslational modification] 226186008706 intermolecular recognition site; other site 226186008707 dimerization interface [polypeptide binding]; other site 226186008708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008710 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 226186008711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186008712 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008713 Sulfatase; Region: Sulfatase; cl19157 226186008714 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186008715 SusD family; Region: SusD; pfam07980 226186008716 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008717 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008718 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186008720 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186008721 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186008722 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008723 Sulfatase; Region: Sulfatase; pfam00884 226186008724 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008725 Sulfatase; Region: Sulfatase; pfam00884 226186008726 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 226186008727 active site 226186008728 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008729 Sulfatase; Region: Sulfatase; pfam00884 226186008730 acyl transferase; Provisional; Region: luxD; PRK13604 226186008731 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226186008732 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 226186008733 MFS transport protein AraJ; Provisional; Region: PRK10091 226186008734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186008735 putative substrate translocation pore; other site 226186008736 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008737 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008738 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186008739 PA14 domain; Region: PA14; pfam07691 226186008740 Proline dehydrogenase; Region: Pro_dh; pfam01619 226186008741 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 226186008742 Glutamate binding site [chemical binding]; other site 226186008743 NAD binding site [chemical binding]; other site 226186008744 catalytic residues [active] 226186008745 GTP-binding protein YchF; Reviewed; Region: PRK09601 226186008746 YchF GTPase; Region: YchF; cd01900 226186008747 G1 box; other site 226186008748 GTP/Mg2+ binding site [chemical binding]; other site 226186008749 Switch I region; other site 226186008750 G2 box; other site 226186008751 Switch II region; other site 226186008752 G3 box; other site 226186008753 G4 box; other site 226186008754 G5 box; other site 226186008755 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 226186008756 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 226186008757 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226186008758 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226186008759 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 226186008760 Chloramphenicol acetyltransferase; Region: CAT; smart01059 226186008761 MAC/Perforin domain; Region: MACPF; cl02616 226186008762 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 226186008763 MutS domain I; Region: MutS_I; pfam01624 226186008764 MutS domain II; Region: MutS_II; pfam05188 226186008765 MutS domain III; Region: MutS_III; pfam05192 226186008766 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 226186008767 Walker A/P-loop; other site 226186008768 ATP binding site [chemical binding]; other site 226186008769 Q-loop/lid; other site 226186008770 ABC transporter signature motif; other site 226186008771 Walker B; other site 226186008772 D-loop; other site 226186008773 H-loop/switch region; other site 226186008774 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186008775 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 226186008776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008777 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008779 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186008780 EamA-like transporter family; Region: EamA; pfam00892 226186008781 EamA-like transporter family; Region: EamA; pfam00892 226186008782 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186008783 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186008784 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 226186008785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226186008786 active site 226186008787 HIGH motif; other site 226186008788 nucleotide binding site [chemical binding]; other site 226186008789 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226186008790 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 226186008791 active site 226186008792 KMSKS motif; other site 226186008793 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 226186008794 tRNA binding surface [nucleotide binding]; other site 226186008795 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226186008796 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226186008797 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226186008798 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 226186008799 active site 226186008800 dimerization interface [polypeptide binding]; other site 226186008801 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186008802 ligand binding site [chemical binding]; other site 226186008803 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186008804 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186008805 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 226186008806 Melibiase; Region: Melibiase; pfam02065 226186008807 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186008808 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008809 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 226186008810 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008811 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008812 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008815 dimer interface [polypeptide binding]; other site 226186008816 phosphorylation site [posttranslational modification] 226186008817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008818 ATP binding site [chemical binding]; other site 226186008819 Mg2+ binding site [ion binding]; other site 226186008820 G-X-G motif; other site 226186008821 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 226186008822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008823 active site 226186008824 phosphorylation site [posttranslational modification] 226186008825 intermolecular recognition site; other site 226186008826 dimerization interface [polypeptide binding]; other site 226186008827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008829 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186008830 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 226186008831 active site 226186008832 DNA binding site [nucleotide binding] 226186008833 Int/Topo IB signature motif; other site 226186008834 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186008835 Int/Topo IB signature motif; other site 226186008836 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 226186008837 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186008838 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186008839 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186008840 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186008841 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 226186008842 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186008843 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186008844 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 226186008845 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186008846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008847 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 226186008848 Divergent AAA domain; Region: AAA_4; pfam04326 226186008849 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186008850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186008851 sequence-specific DNA binding site [nucleotide binding]; other site 226186008852 salt bridge; other site 226186008853 Two component regulator propeller; Region: Reg_prop; pfam07494 226186008854 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186008855 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 226186008856 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008857 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008858 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186008859 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008860 SusD family; Region: SusD; pfam07980 226186008861 Right handed beta helix region; Region: Beta_helix; pfam13229 226186008862 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226186008863 active site 226186008864 catalytic triad [active] 226186008865 oxyanion hole [active] 226186008866 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186008867 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 226186008868 putative active site [active] 226186008869 catalytic site [active] 226186008870 putative metal binding site [ion binding]; other site 226186008871 oligomer interface [polypeptide binding]; other site 226186008872 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186008873 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186008874 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186008875 quinolinate synthetase; Provisional; Region: PRK09375 226186008876 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226186008877 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226186008878 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 226186008879 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186008880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186008881 FeS/SAM binding site; other site 226186008882 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186008883 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186008884 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 226186008885 putative active site [active] 226186008886 putative catalytic site [active] 226186008887 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186008888 Interdomain contacts; other site 226186008889 Cytokine receptor motif; other site 226186008890 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186008891 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 226186008892 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186008893 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186008894 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186008895 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186008896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186008897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186008898 dimer interface [polypeptide binding]; other site 226186008899 phosphorylation site [posttranslational modification] 226186008900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186008901 ATP binding site [chemical binding]; other site 226186008902 Mg2+ binding site [ion binding]; other site 226186008903 G-X-G motif; other site 226186008904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186008905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186008906 active site 226186008907 phosphorylation site [posttranslational modification] 226186008908 intermolecular recognition site; other site 226186008909 dimerization interface [polypeptide binding]; other site 226186008910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186008911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186008912 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186008913 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 226186008914 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186008915 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008916 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186008917 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186008918 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186008919 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186008920 SusD family; Region: SusD; pfam07980 226186008921 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 226186008922 active site 226186008923 catalytic residues [active] 226186008924 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186008925 Sulfatase; Region: Sulfatase; pfam00884 226186008926 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186008927 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186008928 active site 226186008929 Fn3 associated; Region: Fn3_assoc; pfam13287 226186008930 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186008931 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226186008932 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186008933 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186008934 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186008935 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186008936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 226186008937 putative transporter; Provisional; Region: PRK11660 226186008938 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 226186008939 Sulfate transporter family; Region: Sulfate_transp; pfam00916 226186008940 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226186008941 Rubrerythrin [Energy production and conversion]; Region: COG1592 226186008942 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 226186008943 binuclear metal center [ion binding]; other site 226186008944 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 226186008945 iron binding site [ion binding]; other site 226186008946 L-aspartate oxidase; Provisional; Region: PRK09077 226186008947 L-aspartate oxidase; Provisional; Region: PRK06175 226186008948 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 226186008949 Bacterial PH domain; Region: bPH_4; pfam06713 226186008950 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 226186008951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186008952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186008953 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226186008954 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 226186008955 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 226186008956 RNA polymerase sigma factor; Provisional; Region: PRK12513 226186008957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186008958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186008959 DNA binding residues [nucleotide binding] 226186008960 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186008961 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186008962 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186008963 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 226186008964 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 226186008965 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 226186008966 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 226186008967 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226186008968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186008969 FeS/SAM binding site; other site 226186008970 TRAM domain; Region: TRAM; pfam01938 226186008971 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 226186008972 Predicted transcriptional regulator [Transcription]; Region: COG2932 226186008973 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226186008974 Catalytic site [active] 226186008975 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186008976 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186008977 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186008978 amidase catalytic site [active] 226186008979 Zn binding residues [ion binding]; other site 226186008980 substrate binding site [chemical binding]; other site 226186008981 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 226186008982 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 226186008983 MltA specific insert domain; Region: MltA; cl08398 226186008984 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 226186008985 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 226186008986 JAB-like toxin 1; Region: Toxin-JAB1; pfam15659 226186008987 Immunity protein 40; Region: Imm40; pfam15582 226186008988 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 226186008989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186008990 S-adenosylmethionine binding site [chemical binding]; other site 226186008991 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 226186008992 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 226186008993 Bacitracin resistance protein BacA; Region: BacA; pfam02673 226186008994 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 226186008995 RNA binding site [nucleotide binding]; other site 226186008996 active site 226186008997 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 226186008998 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 226186008999 catalytic center binding site [active] 226186009000 ATP binding site [chemical binding]; other site 226186009001 S-adenosylmethionine synthetase; Validated; Region: PRK05250 226186009002 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 226186009003 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 226186009004 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 226186009005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009006 binding surface 226186009007 TPR motif; other site 226186009008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009009 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 226186009010 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186009011 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 226186009012 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 226186009013 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 226186009014 active site 226186009015 ribonuclease P; Reviewed; Region: rnpA; PRK01903 226186009016 Haemolytic domain; Region: Haemolytic; pfam01809 226186009017 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226186009018 active site 226186009019 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 226186009020 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 226186009021 active site 226186009022 HIGH motif; other site 226186009023 dimer interface [polypeptide binding]; other site 226186009024 KMSKS motif; other site 226186009025 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 226186009026 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 226186009027 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 226186009028 NADP binding site [chemical binding]; other site 226186009029 homodimer interface [polypeptide binding]; other site 226186009030 active site 226186009031 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 226186009032 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186009033 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 226186009034 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186009035 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009036 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009037 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009038 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009039 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009040 TonB dependent receptor; Region: TonB_dep_Rec; cl17754 226186009041 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009042 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009043 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009044 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009045 TonB dependent receptor; Region: TonB_dep_Rec; cl17754 226186009046 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186009047 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009048 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 226186009049 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186009050 epoxyqueuosine reductase; Region: TIGR00276 226186009051 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 226186009052 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226186009053 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226186009054 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 226186009055 NodB motif; other site 226186009056 active site 226186009057 catalytic site [active] 226186009058 metal binding site [ion binding]; metal-binding site 226186009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186009060 putative substrate translocation pore; other site 226186009061 CCC1-related family of proteins; Region: CCC1_like; cd01059 226186009062 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226186009063 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 226186009064 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226186009065 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 226186009066 putative metal binding residues [ion binding]; other site 226186009067 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 226186009068 Predicted membrane protein [Function unknown]; Region: COG1238 226186009069 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 226186009070 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 226186009071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186009072 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 226186009073 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 226186009074 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226186009075 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186009076 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 226186009077 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 226186009078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226186009079 serine O-acetyltransferase; Region: cysE; TIGR01172 226186009080 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226186009081 trimer interface [polypeptide binding]; other site 226186009082 active site 226186009083 substrate binding site [chemical binding]; other site 226186009084 CoA binding site [chemical binding]; other site 226186009085 TPR repeat; Region: TPR_11; pfam13414 226186009086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009087 binding surface 226186009088 TPR motif; other site 226186009089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009090 binding surface 226186009091 TPR motif; other site 226186009092 Histidine kinase; Region: His_kinase; pfam06580 226186009093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186009094 ATP binding site [chemical binding]; other site 226186009095 Mg2+ binding site [ion binding]; other site 226186009096 G-X-G motif; other site 226186009097 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186009098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186009099 active site 226186009100 phosphorylation site [posttranslational modification] 226186009101 intermolecular recognition site; other site 226186009102 dimerization interface [polypeptide binding]; other site 226186009103 LytTr DNA-binding domain; Region: LytTR; smart00850 226186009104 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 226186009105 DNA polymerase I; Provisional; Region: PRK05755 226186009106 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226186009107 active site 226186009108 metal binding site 1 [ion binding]; metal-binding site 226186009109 putative 5' ssDNA interaction site; other site 226186009110 metal binding site 3; metal-binding site 226186009111 metal binding site 2 [ion binding]; metal-binding site 226186009112 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226186009113 putative DNA binding site [nucleotide binding]; other site 226186009114 putative metal binding site [ion binding]; other site 226186009115 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 226186009116 active site 226186009117 catalytic site [active] 226186009118 substrate binding site [chemical binding]; other site 226186009119 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 226186009120 active site 226186009121 DNA binding site [nucleotide binding] 226186009122 catalytic site [active] 226186009123 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226186009124 substrate binding pocket [chemical binding]; other site 226186009125 chain length determination region; other site 226186009126 substrate-Mg2+ binding site; other site 226186009127 catalytic residues [active] 226186009128 aspartate-rich region 1; other site 226186009129 active site lid residues [active] 226186009130 aspartate-rich region 2; other site 226186009131 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 226186009132 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 226186009133 intersubunit interface [polypeptide binding]; other site 226186009134 active site 226186009135 catalytic residue [active] 226186009136 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 226186009137 homodimer interface [polypeptide binding]; other site 226186009138 metal binding site [ion binding]; metal-binding site 226186009139 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 226186009140 putative active site [active] 226186009141 dimerization interface [polypeptide binding]; other site 226186009142 putative tRNAtyr binding site [nucleotide binding]; other site 226186009143 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 226186009144 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226186009145 GIY-YIG motif/motif A; other site 226186009146 active site 226186009147 catalytic site [active] 226186009148 putative DNA binding site [nucleotide binding]; other site 226186009149 metal binding site [ion binding]; metal-binding site 226186009150 Conserved oligomeric complex COG6; Region: COG6; cl19764 226186009151 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 226186009152 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226186009153 DNA binding site [nucleotide binding] 226186009154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186009155 active site 226186009156 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 226186009157 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 226186009158 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 226186009159 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186009160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186009161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186009162 DNA binding residues [nucleotide binding] 226186009163 FecR protein; Region: FecR; pfam04773 226186009164 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186009165 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186009166 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009167 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009168 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009169 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009170 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009171 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 226186009172 active site 226186009173 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 226186009174 active site 226186009175 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186009176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186009177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186009178 DNA binding residues [nucleotide binding] 226186009179 putative anti-sigmaE protein; Provisional; Region: PRK13920 226186009180 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186009181 FecR protein; Region: FecR; pfam04773 226186009182 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186009183 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009184 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009185 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009186 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009187 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009188 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 226186009189 active site 226186009190 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 226186009191 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 226186009192 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 226186009193 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 226186009194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186009195 Walker A motif; other site 226186009196 ATP binding site [chemical binding]; other site 226186009197 Walker B motif; other site 226186009198 arginine finger; other site 226186009199 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 226186009200 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186009201 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226186009202 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226186009203 Domain of unknown function (DUF389); Region: DUF389; pfam04087 226186009204 Peptidase S46; Region: Peptidase_S46; pfam10459 226186009205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186009206 EamA-like transporter family; Region: EamA; pfam00892 226186009207 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226186009208 Peptidase family S41; Region: Peptidase_S41; pfam03572 226186009209 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186009210 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186009211 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186009212 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226186009213 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186009214 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186009215 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186009216 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186009217 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 226186009218 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186009219 sugar binding site [chemical binding]; other site 226186009220 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186009221 sugar binding site [chemical binding]; other site 226186009222 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186009223 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186009224 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186009225 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009226 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009227 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186009228 SusD family; Region: SusD; pfam07980 226186009229 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009230 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009232 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009233 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009234 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186009235 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186009236 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 226186009237 trimer interface [polypeptide binding]; other site 226186009238 active site 226186009239 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 226186009240 catalytic site [active] 226186009241 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186009242 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 226186009243 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186009244 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 226186009245 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186009246 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186009247 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186009248 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186009249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186009250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186009251 dimer interface [polypeptide binding]; other site 226186009252 phosphorylation site [posttranslational modification] 226186009253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186009254 ATP binding site [chemical binding]; other site 226186009255 Mg2+ binding site [ion binding]; other site 226186009256 G-X-G motif; other site 226186009257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186009258 active site 226186009259 phosphorylation site [posttranslational modification] 226186009260 intermolecular recognition site; other site 226186009261 dimerization interface [polypeptide binding]; other site 226186009262 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186009263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186009264 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226186009265 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226186009266 ATP binding site [chemical binding]; other site 226186009267 Mg++ binding site [ion binding]; other site 226186009268 motif III; other site 226186009269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186009270 nucleotide binding region [chemical binding]; other site 226186009271 ATP-binding site [chemical binding]; other site 226186009272 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 226186009273 RNA binding site [nucleotide binding]; other site 226186009274 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 226186009275 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 226186009276 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 226186009277 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 226186009278 putative substrate binding site [chemical binding]; other site 226186009279 putative ATP binding site [chemical binding]; other site 226186009280 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 226186009281 putative active site [active] 226186009282 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 226186009283 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186009284 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226186009285 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186009286 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226186009287 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009288 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009289 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009290 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009291 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009292 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 226186009293 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186009294 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 226186009295 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186009296 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186009297 WbqC-like protein family; Region: WbqC; pfam08889 226186009298 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226186009299 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226186009300 Catalytic site [active] 226186009301 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226186009302 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 226186009303 signal peptidase I; Provisional; Region: PRK10861 226186009304 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226186009305 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 226186009306 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 226186009307 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 226186009308 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 226186009309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226186009310 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186009311 catalytic residues [active] 226186009312 Lyase, N terminal; Region: Lyase_N; pfam09092 226186009313 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 226186009314 substrate binding site [chemical binding]; other site 226186009315 catalytic residues [active] 226186009316 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226186009317 FMN binding site [chemical binding]; other site 226186009318 active site 226186009319 catalytic residues [active] 226186009320 substrate binding site [chemical binding]; other site 226186009321 Divergent AAA domain; Region: AAA_4; pfam04326 226186009322 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186009323 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009324 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009325 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009326 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009327 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009328 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009329 Sulfatase; Region: Sulfatase; pfam00884 226186009330 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 226186009331 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186009332 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186009333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186009334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186009335 dimer interface [polypeptide binding]; other site 226186009336 phosphorylation site [posttranslational modification] 226186009337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186009338 ATP binding site [chemical binding]; other site 226186009339 Mg2+ binding site [ion binding]; other site 226186009340 G-X-G motif; other site 226186009341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186009342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186009343 active site 226186009344 phosphorylation site [posttranslational modification] 226186009345 intermolecular recognition site; other site 226186009346 dimerization interface [polypeptide binding]; other site 226186009347 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186009348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186009349 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 226186009350 putative ligand binding site [chemical binding]; other site 226186009351 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 226186009352 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 226186009353 active site 226186009354 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186009355 Outer membrane efflux protein; Region: OEP; pfam02321 226186009356 Outer membrane efflux protein; Region: OEP; pfam02321 226186009357 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226186009358 MMPL family; Region: MMPL; cl14618 226186009359 MMPL family; Region: MMPL; cl14618 226186009360 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186009361 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186009362 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186009363 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 226186009364 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186009365 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186009366 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186009367 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186009368 Bacterial Ig-like domain; Region: Big_5; pfam13205 226186009369 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186009370 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 226186009371 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 226186009372 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 226186009373 CoenzymeA binding site [chemical binding]; other site 226186009374 subunit interaction site [polypeptide binding]; other site 226186009375 PHB binding site; other site 226186009376 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009377 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009378 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009379 SusD family; Region: SusD; pfam07980 226186009380 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009381 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009382 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009383 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009384 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009385 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226186009386 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009387 Sulfatase; Region: Sulfatase; pfam00884 226186009388 Lyase, N terminal; Region: Lyase_N; pfam09092 226186009389 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 226186009390 substrate binding site [chemical binding]; other site 226186009391 catalytic residues [active] 226186009392 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 226186009393 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 226186009394 active site 226186009395 HIGH motif; other site 226186009396 KMSKS motif; other site 226186009397 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226186009398 tRNA binding surface [nucleotide binding]; other site 226186009399 anticodon binding site; other site 226186009400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186009401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226186009402 active site 226186009403 motif I; other site 226186009404 motif II; other site 226186009405 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186009406 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226186009407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186009408 putative Mg++ binding site [ion binding]; other site 226186009409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186009410 nucleotide binding region [chemical binding]; other site 226186009411 ATP-binding site [chemical binding]; other site 226186009412 tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665 226186009413 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226186009414 Ligand Binding Site [chemical binding]; other site 226186009415 GH3 auxin-responsive promoter; Region: GH3; pfam03321 226186009416 indole-3-acetic acid-amido synthetase; Region: PLN02249 226186009417 6-phosphofructokinase; Provisional; Region: PRK03202 226186009418 active site 226186009419 ADP/pyrophosphate binding site [chemical binding]; other site 226186009420 dimerization interface [polypeptide binding]; other site 226186009421 allosteric effector site; other site 226186009422 fructose-1,6-bisphosphate binding site; other site 226186009423 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 226186009424 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226186009425 dimerization interface [polypeptide binding]; other site 226186009426 active site 226186009427 metal binding site [ion binding]; metal-binding site 226186009428 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 226186009429 dsRNA binding site [nucleotide binding]; other site 226186009430 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 226186009431 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 226186009432 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 226186009433 dimer interface [polypeptide binding]; other site 226186009434 active site 226186009435 acyl carrier protein; Provisional; Region: acpP; PRK00982 226186009436 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 226186009437 active site 226186009438 substrate binding site [chemical binding]; other site 226186009439 cosubstrate binding site; other site 226186009440 catalytic site [active] 226186009441 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 226186009442 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 226186009443 ligand binding site [chemical binding]; other site 226186009444 NAD binding site [chemical binding]; other site 226186009445 catalytic site [active] 226186009446 homodimer interface [polypeptide binding]; other site 226186009447 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 226186009448 putative active site [active] 226186009449 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 226186009450 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 226186009451 Substrate binding site; other site 226186009452 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226186009453 metal-binding site 226186009454 Glycosyl transferase family 64 domain; Region: Glyco_transf_64; pfam09258 226186009455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186009456 active site 226186009457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186009458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186009459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186009460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186009461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186009462 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186009463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186009464 active site 226186009465 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186009466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186009467 active site 226186009468 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186009469 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186009470 active site 226186009471 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226186009472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186009473 Coenzyme A binding pocket [chemical binding]; other site 226186009474 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 226186009475 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 226186009476 aspartate aminotransferase; Provisional; Region: PRK05764 226186009477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186009478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186009479 homodimer interface [polypeptide binding]; other site 226186009480 catalytic residue [active] 226186009481 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226186009482 inhibitor-cofactor binding pocket; inhibition site 226186009483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186009484 catalytic residue [active] 226186009485 Core-2/I-Branching enzyme; Region: Branch; pfam02485 226186009486 GtrA-like protein; Region: GtrA; pfam04138 226186009487 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 226186009488 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 226186009489 Ligand binding site; other site 226186009490 Putative Catalytic site; other site 226186009491 DXD motif; other site 226186009492 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186009493 S25 ribosomal protein; Region: Ribosomal_S25; cl02050 226186009494 VirE N-terminal domain; Region: VirE_N; pfam08800 226186009495 Virulence-associated protein E; Region: VirE; pfam05272 226186009496 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186009497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226186009498 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226186009499 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 226186009500 Walker A/P-loop; other site 226186009501 ATP binding site [chemical binding]; other site 226186009502 Q-loop/lid; other site 226186009503 ABC transporter signature motif; other site 226186009504 Walker B; other site 226186009505 D-loop; other site 226186009506 H-loop/switch region; other site 226186009507 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 226186009508 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 226186009509 putative active site [active] 226186009510 putative catalytic site [active] 226186009511 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 226186009512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186009513 active site 226186009514 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 226186009515 GtrA-like protein; Region: GtrA; pfam04138 226186009516 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 226186009517 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 226186009518 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 226186009519 RNA/DNA hybrid binding site [nucleotide binding]; other site 226186009520 active site 226186009521 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226186009522 dimer interface [polypeptide binding]; other site 226186009523 FMN binding site [chemical binding]; other site 226186009524 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 226186009525 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 226186009526 ADP binding site [chemical binding]; other site 226186009527 magnesium binding site [ion binding]; other site 226186009528 putative shikimate binding site; other site 226186009529 arginine decarboxylase; Provisional; Region: PRK05354 226186009530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 226186009531 dimer interface [polypeptide binding]; other site 226186009532 active site 226186009533 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226186009534 catalytic residues [active] 226186009535 substrate binding site [chemical binding]; other site 226186009536 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 226186009537 nucleotide binding site [chemical binding]; other site 226186009538 N-acetyl-L-glutamate binding site [chemical binding]; other site 226186009539 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 226186009540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186009541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186009542 DNA binding residues [nucleotide binding] 226186009543 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 226186009544 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 226186009545 Protein of unknown function DUF45; Region: DUF45; pfam01863 226186009546 TIR domain; Region: TIR_2; pfam13676 226186009547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009548 TPR motif; other site 226186009549 binding surface 226186009550 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 226186009551 Sel1-like repeats; Region: SEL1; smart00671 226186009552 hypothetical protein; Validated; Region: PRK02001 226186009553 heptamer interface [polypeptide binding]; other site 226186009554 Sm1 motif; other site 226186009555 hexamer interface [polypeptide binding]; other site 226186009556 RNA binding site [nucleotide binding]; other site 226186009557 Sm2 motif; other site 226186009558 transcription termination factor NusA; Region: NusA; TIGR01953 226186009559 NusA N-terminal domain; Region: NusA_N; pfam08529 226186009560 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 226186009561 RNA binding site [nucleotide binding]; other site 226186009562 homodimer interface [polypeptide binding]; other site 226186009563 NusA-like KH domain; Region: KH_5; pfam13184 226186009564 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226186009565 G-X-X-G motif; other site 226186009566 translation initiation factor IF-2; Validated; Region: infB; PRK05306 226186009567 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226186009568 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 226186009569 G1 box; other site 226186009570 putative GEF interaction site [polypeptide binding]; other site 226186009571 GTP/Mg2+ binding site [chemical binding]; other site 226186009572 Switch I region; other site 226186009573 G2 box; other site 226186009574 G3 box; other site 226186009575 Switch II region; other site 226186009576 G4 box; other site 226186009577 G5 box; other site 226186009578 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 226186009579 Translation-initiation factor 2; Region: IF-2; pfam11987 226186009580 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 226186009581 Colicin V production protein; Region: Colicin_V; pfam02674 226186009582 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 226186009583 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 226186009584 FeS assembly ATPase SufC; Region: sufC; TIGR01978 226186009585 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 226186009586 Walker A/P-loop; other site 226186009587 ATP binding site [chemical binding]; other site 226186009588 Q-loop/lid; other site 226186009589 seadornavirus VP2 protein; Region: seadorna_VP2; TIGR04236 226186009590 ABC transporter signature motif; other site 226186009591 Walker B; other site 226186009592 D-loop; other site 226186009593 H-loop/switch region; other site 226186009594 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 226186009595 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 226186009596 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 226186009597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226186009598 catalytic residue [active] 226186009599 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 226186009600 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 226186009601 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 226186009602 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 226186009603 RNA/DNA hybrid binding site [nucleotide binding]; other site 226186009604 active site 226186009605 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226186009606 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 226186009607 Cl binding site [ion binding]; other site 226186009608 oligomer interface [polypeptide binding]; other site 226186009609 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 226186009610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186009611 Transposase [DNA replication, recombination, and repair]; Region: COG5433 226186009612 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186009613 catalytic residues [active] 226186009614 phosphoglyceromutase; Provisional; Region: PRK05434 226186009615 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226186009616 MG2 domain; Region: A2M_N; cl19929 226186009617 MG2 domain; Region: A2M_N; cl19929 226186009618 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226186009619 O-Antigen ligase; Region: Wzy_C; pfam04932 226186009620 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 226186009621 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226186009622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186009623 ATP binding site [chemical binding]; other site 226186009624 Mg2+ binding site [ion binding]; other site 226186009625 G-X-G motif; other site 226186009626 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226186009627 anchoring element; other site 226186009628 dimer interface [polypeptide binding]; other site 226186009629 ATP binding site [chemical binding]; other site 226186009630 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 226186009631 active site 226186009632 putative metal-binding site [ion binding]; other site 226186009633 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226186009634 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 226186009635 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 226186009636 Recombination protein O N terminal; Region: RecO_N; pfam11967 226186009637 Recombination protein O C terminal; Region: RecO_C; pfam02565 226186009638 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186009639 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186009640 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 226186009641 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 226186009642 TPR repeat; Region: TPR_11; pfam13414 226186009643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009644 binding surface 226186009645 TPR motif; other site 226186009646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009648 TPR motif; other site 226186009649 binding surface 226186009650 Yqey-like protein; Region: YqeY; cl17540 226186009651 cell division protein FtsZ; Validated; Region: PRK09330 226186009652 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 226186009653 nucleotide binding site [chemical binding]; other site 226186009654 SulA interaction site; other site 226186009655 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 226186009656 Cell division protein FtsA; Region: FtsA; smart00842 226186009657 Cell division protein FtsA; Region: FtsA; pfam14450 226186009658 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 226186009659 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226186009660 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186009661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226186009662 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 226186009663 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226186009664 homodimer interface [polypeptide binding]; other site 226186009665 active site 226186009666 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226186009667 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 226186009668 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186009669 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226186009670 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 226186009671 Mg++ binding site [ion binding]; other site 226186009672 putative catalytic motif [active] 226186009673 putative substrate binding site [chemical binding]; other site 226186009674 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 226186009675 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226186009676 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186009677 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226186009678 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226186009679 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226186009680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226186009681 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226186009682 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 226186009683 cell division protein MraZ; Reviewed; Region: PRK00326 226186009684 MraZ protein; Region: MraZ; pfam02381 226186009685 MraZ protein; Region: MraZ; pfam02381 226186009686 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186009687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186009688 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186009689 DNA binding residues [nucleotide binding] 226186009690 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 226186009691 putative acyl-acceptor binding pocket; other site 226186009692 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 226186009693 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 226186009694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 226186009695 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 226186009696 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 226186009697 trimer interface [polypeptide binding]; other site 226186009698 active site 226186009699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009700 binding surface 226186009701 TPR motif; other site 226186009702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186009703 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186009704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009705 binding surface 226186009706 TPR motif; other site 226186009707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009708 TPR motif; other site 226186009709 binding surface 226186009710 TPR repeat; Region: TPR_11; pfam13414 226186009711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009712 binding surface 226186009713 TPR motif; other site 226186009714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009715 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 226186009716 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 226186009717 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 226186009718 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186009719 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186009720 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186009721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186009722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186009723 dimer interface [polypeptide binding]; other site 226186009724 phosphorylation site [posttranslational modification] 226186009725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186009726 ATP binding site [chemical binding]; other site 226186009727 Mg2+ binding site [ion binding]; other site 226186009728 G-X-G motif; other site 226186009729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186009730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186009731 active site 226186009732 phosphorylation site [posttranslational modification] 226186009733 intermolecular recognition site; other site 226186009734 dimerization interface [polypeptide binding]; other site 226186009735 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186009736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186009737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186009738 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 226186009739 active site 226186009740 ApbE family; Region: ApbE; cl19294 226186009741 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186009742 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186009743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186009744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186009745 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186009746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186009747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226186009748 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009749 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009750 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009751 SusD family; Region: SusD; pfam07980 226186009752 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009753 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009754 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009755 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009756 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009757 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009758 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186009759 active site 226186009760 DNA binding site [nucleotide binding] 226186009761 Int/Topo IB signature motif; other site 226186009762 Integrase core domain; Region: rve; pfam00665 226186009763 Integrase core domain; Region: rve_3; pfam13683 226186009764 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009765 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009766 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009767 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009768 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009769 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009770 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009771 SusD family; Region: SusD; pfam07980 226186009772 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009773 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009774 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009775 Sulfatase; Region: Sulfatase; pfam00884 226186009776 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009777 Sulfatase; Region: Sulfatase; pfam00884 226186009778 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009779 Sulfatase; Region: Sulfatase; pfam00884 226186009780 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186009781 Sulfatase; Region: Sulfatase; pfam00884 226186009782 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 226186009783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226186009784 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 226186009785 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009786 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009787 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009788 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009789 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009790 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009791 envelope glycoprotein H; Provisional; Region: PHA03295 226186009792 SusD family; Region: SusD; pfam07980 226186009793 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009794 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009795 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 226186009796 putative metal binding residues [ion binding]; other site 226186009797 signature motif; other site 226186009798 dimer interface [polypeptide binding]; other site 226186009799 active site 226186009800 polyP binding site; other site 226186009801 substrate binding site [chemical binding]; other site 226186009802 acceptor-phosphate pocket; other site 226186009803 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 226186009804 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186009805 CotH protein; Region: CotH; pfam08757 226186009806 Fibronectin type 3 domain; Region: FN3; smart00060 226186009807 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186009808 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009809 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186009810 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009811 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009812 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009813 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009814 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009815 SusD family; Region: SusD; pfam07980 226186009816 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186009817 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186009818 MG2 domain; Region: A2M_N; cl19929 226186009819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009820 Tetratricopeptide repeat; Region: TPR_19; pfam14559 226186009821 TPR motif; other site 226186009822 binding surface 226186009823 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 226186009824 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009825 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186009826 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186009827 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186009828 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 226186009829 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 226186009830 active site 226186009831 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 226186009832 putative substrate binding site [chemical binding]; other site 226186009833 active site 226186009834 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 226186009835 putative substrate binding site [chemical binding]; other site 226186009836 active site 226186009837 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186009838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186009839 DNA binding residues [nucleotide binding] 226186009840 FecR protein; Region: FecR; pfam04773 226186009841 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186009842 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009843 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009845 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186009846 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186009847 SusD family; Region: SusD; pfam07980 226186009848 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186009849 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186009850 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186009851 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186009852 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009853 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186009854 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186009855 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 226186009856 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226186009857 active site 226186009858 catalytic residues [active] 226186009859 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186009860 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186009861 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186009862 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 226186009863 active site 226186009864 catalytic residues [active] 226186009865 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226186009866 O-Antigen ligase; Region: Wzy_C; pfam04932 226186009867 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 226186009868 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 226186009869 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 226186009870 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186009871 O-Antigen ligase; Region: Wzy_C; pfam04932 226186009872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009873 TPR motif; other site 226186009874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009875 binding surface 226186009876 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186009877 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 226186009878 Protein of unknown function (DUF327); Region: DUF327; cl00753 226186009879 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 226186009880 AAA domain; Region: AAA_14; pfam13173 226186009881 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 226186009882 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 226186009883 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 226186009884 metal binding site [ion binding]; metal-binding site 226186009885 dimer interface [polypeptide binding]; other site 226186009886 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 226186009887 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 226186009888 acyl-activating enzyme (AAE) consensus motif; other site 226186009889 putative AMP binding site [chemical binding]; other site 226186009890 putative active site [active] 226186009891 putative CoA binding site [chemical binding]; other site 226186009892 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186009893 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226186009894 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186009895 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186009896 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186009897 This domain is found in peptide chain release factors; Region: PCRF; smart00937 226186009898 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 226186009899 RF-1 domain; Region: RF-1; pfam00472 226186009900 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 226186009901 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 226186009902 putative active site [active] 226186009903 putative metal binding residues [ion binding]; other site 226186009904 signature motif; other site 226186009905 putative dimer interface [polypeptide binding]; other site 226186009906 putative phosphate binding site [ion binding]; other site 226186009907 Predicted membrane protein [Function unknown]; Region: COG3174 226186009908 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 226186009909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186009910 non-specific DNA binding site [nucleotide binding]; other site 226186009911 salt bridge; other site 226186009912 sequence-specific DNA binding site [nucleotide binding]; other site 226186009913 Transposase domain (DUF772); Region: DUF772; pfam05598 226186009914 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 226186009915 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186009916 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 226186009917 active site 226186009918 substrate binding site [chemical binding]; other site 226186009919 Mg2+ binding site [ion binding]; other site 226186009920 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 226186009921 putative catalytic site [active] 226186009922 putative metal binding site [ion binding]; other site 226186009923 putative phosphate binding site [ion binding]; other site 226186009924 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186009925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009926 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 226186009927 active site 226186009928 substrate binding site [chemical binding]; other site 226186009929 Mg2+ binding site [ion binding]; other site 226186009930 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 226186009931 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009932 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186009933 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009934 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186009935 Putative glucoamylase; Region: Glycoamylase; cl19893 226186009936 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186009937 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 226186009938 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186009939 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186009940 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186009941 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186009942 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186009943 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186009944 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186009945 TPR repeat; Region: TPR_11; pfam13414 226186009946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009947 binding surface 226186009948 TPR motif; other site 226186009949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186009951 binding surface 226186009952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186009953 TPR motif; other site 226186009954 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 226186009955 Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937 226186009956 substrate binding site [chemical binding]; other site 226186009957 ATP binding site [chemical binding]; other site 226186009958 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 226186009959 active site triad [active] 226186009960 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 226186009961 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 226186009962 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226186009963 CAP-like domain; other site 226186009964 active site 226186009965 primary dimer interface [polypeptide binding]; other site 226186009966 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186009967 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186009968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186009969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186009970 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226186009971 ApbE family; Region: ApbE; pfam02424 226186009972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 226186009973 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 226186009974 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226186009975 active site 226186009976 trimer interface [polypeptide binding]; other site 226186009977 allosteric site; other site 226186009978 active site lid [active] 226186009979 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186009980 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226186009981 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226186009982 active site 226186009983 dimer interface [polypeptide binding]; other site 226186009984 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186009985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186009986 putative substrate translocation pore; other site 226186009987 L-fucose transporter; Provisional; Region: PRK10133; cl17665 226186009988 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 226186009989 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 226186009990 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 226186009991 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 226186009992 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 226186009993 Putative Ig domain; Region: He_PIG; pfam05345 226186009994 alpha-galactosidase; Region: PLN02808; cl17638 226186009995 alpha-galactosidase; Region: PLN02692 226186009996 N-terminus of Esterase_SGNH_hydro-type; Region: GxDLY; pfam14607 226186009997 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 226186009998 active site 226186009999 catalytic triad [active] 226186010000 oxyanion hole [active] 226186010001 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186010002 Interdomain contacts; other site 226186010003 Cytokine receptor motif; other site 226186010004 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 226186010005 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 226186010006 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186010007 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186010008 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186010009 active site 226186010010 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186010011 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186010012 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186010013 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186010014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186010015 nucleotide binding site [chemical binding]; other site 226186010016 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 226186010017 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226186010018 dimer interface [polypeptide binding]; other site 226186010019 active site 226186010020 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226186010021 dimer interface [polypeptide binding]; other site 226186010022 active site 226186010023 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186010024 SusD family; Region: SusD; pfam07980 226186010025 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010026 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010027 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010028 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010029 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186010030 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 226186010031 dimerization interface [polypeptide binding]; other site 226186010032 putative active cleft [active] 226186010033 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 226186010034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186010035 putative substrate translocation pore; other site 226186010036 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 226186010037 Domain of unknown function (DUF4434); Region: DUF4434; pfam14488 226186010038 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226186010039 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186010040 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 226186010041 putative dimerization interface [polypeptide binding]; other site 226186010042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226186010043 putative ligand binding site [chemical binding]; other site 226186010044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010046 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186010047 glycyl-tRNA synthetase; Provisional; Region: PRK04173 226186010048 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 226186010049 dimer interface [polypeptide binding]; other site 226186010050 motif 1; other site 226186010051 putative internal virion protein; Provisional; Region: PHA03415 226186010052 active site 226186010053 motif 2; other site 226186010054 motif 3; other site 226186010055 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 226186010056 anticodon binding site; other site 226186010057 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226186010058 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226186010059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226186010060 DNA binding site [nucleotide binding] 226186010061 domain linker motif; other site 226186010062 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226186010063 dimerization interface [polypeptide binding]; other site 226186010064 ligand binding site [chemical binding]; other site 226186010065 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226186010066 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226186010067 active site 226186010068 catalytic tetrad [active] 226186010069 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 226186010070 active site 226186010071 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186010072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186010073 putative substrate translocation pore; other site 226186010074 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226186010075 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 226186010076 putative NAD(P) binding site [chemical binding]; other site 226186010077 catalytic Zn binding site [ion binding]; other site 226186010078 structural Zn binding site [ion binding]; other site 226186010079 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226186010080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 226186010081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186010082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186010083 putative substrate translocation pore; other site 226186010084 Stage II sporulation protein; Region: SpoIID; pfam08486 226186010085 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 226186010086 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186010087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186010088 active site 226186010089 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 226186010090 Na binding site [ion binding]; other site 226186010091 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226186010092 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226186010093 Walker A/P-loop; other site 226186010094 ATP binding site [chemical binding]; other site 226186010095 Q-loop/lid; other site 226186010096 ABC transporter signature motif; other site 226186010097 Walker B; other site 226186010098 D-loop; other site 226186010099 H-loop/switch region; other site 226186010100 PepSY-associated TM helix; Region: PepSY_TM_1; cl19400 226186010101 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186010102 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186010103 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186010104 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 226186010105 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010106 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010107 putative transposase OrfB; Reviewed; Region: PHA02517 226186010108 Integrase core domain; Region: rve; pfam00665 226186010109 Integrase core domain; Region: rve_3; pfam13683 226186010110 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 226186010111 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 226186010112 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 226186010113 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186010114 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186010115 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226186010116 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 226186010117 Ligand Binding Site [chemical binding]; other site 226186010118 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 226186010119 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 226186010120 putative ATP binding site [chemical binding]; other site 226186010121 putative substrate interface [chemical binding]; other site 226186010122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226186010123 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226186010124 Walker A/P-loop; other site 226186010125 ATP binding site [chemical binding]; other site 226186010126 Q-loop/lid; other site 226186010127 ABC transporter signature motif; other site 226186010128 Walker B; other site 226186010129 D-loop; other site 226186010130 H-loop/switch region; other site 226186010131 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186010132 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186010133 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186010134 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 226186010135 Na2 binding site [ion binding]; other site 226186010136 putative substrate binding site 1 [chemical binding]; other site 226186010137 Na binding site 1 [ion binding]; other site 226186010138 putative substrate binding site 2 [chemical binding]; other site 226186010139 Predicted integral membrane protein [Function unknown]; Region: COG5652 226186010140 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 226186010141 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226186010142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186010143 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226186010144 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 226186010145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186010146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010147 dimer interface [polypeptide binding]; other site 226186010148 phosphorylation site [posttranslational modification] 226186010149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010150 ATP binding site [chemical binding]; other site 226186010151 Mg2+ binding site [ion binding]; other site 226186010152 G-X-G motif; other site 226186010153 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 226186010154 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 226186010155 substrate binding pocket [chemical binding]; other site 226186010156 dimer interface [polypeptide binding]; other site 226186010157 inhibitor binding site; inhibition site 226186010158 TIGR00159 family protein; Region: TIGR00159 226186010159 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226186010160 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 226186010161 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 226186010162 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 226186010163 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 226186010164 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 226186010165 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226186010166 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 226186010167 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186010168 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186010169 active site 226186010170 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 226186010171 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 226186010172 active site 226186010173 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186010174 active site 226186010175 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 226186010176 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 226186010177 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 226186010178 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 226186010179 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 226186010180 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 226186010181 putative active site [active] 226186010182 putative catalytic site [active] 226186010183 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186010184 Two component regulator propeller; Region: Reg_prop; pfam07494 226186010185 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186010186 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010188 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186010189 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186010190 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186010191 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 226186010192 putative substrate binding site [chemical binding]; other site 226186010193 active site 226186010194 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186010195 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186010196 active site 226186010197 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186010198 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186010199 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186010200 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 226186010201 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186010202 Domain of unknown function (DUF718); Region: DUF718; pfam05336 226186010203 Cupin domain; Region: Cupin_2; cl17218 226186010204 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 226186010205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010206 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010208 IPT/TIG domain; Region: TIG; pfam01833 226186010209 NHL repeat; Region: NHL; pfam01436 226186010210 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010211 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010212 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010213 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010214 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186010215 SusD family; Region: SusD; pfam07980 226186010216 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186010217 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186010218 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186010219 Domain of unknown function (DUF4488); Region: DUF4488; pfam14869 226186010220 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 226186010221 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 226186010222 putative substrate binding site [chemical binding]; other site 226186010223 active site 226186010224 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 226186010225 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186010226 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186010227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186010228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010229 dimer interface [polypeptide binding]; other site 226186010230 phosphorylation site [posttranslational modification] 226186010231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010232 ATP binding site [chemical binding]; other site 226186010233 Mg2+ binding site [ion binding]; other site 226186010234 G-X-G motif; other site 226186010235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010236 active site 226186010237 phosphorylation site [posttranslational modification] 226186010238 intermolecular recognition site; other site 226186010239 dimerization interface [polypeptide binding]; other site 226186010240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010242 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186010243 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010244 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010245 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010247 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186010248 SusD family; Region: SusD; pfam07980 226186010249 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186010250 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 226186010251 active site 226186010252 catalytic residues [active] 226186010253 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 226186010254 active site 226186010255 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 226186010256 active site 226186010257 BNR repeat-like domain; Region: BNR_2; pfam13088 226186010258 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186010259 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 226186010260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186010261 Coenzyme A binding pocket [chemical binding]; other site 226186010262 Sterol carrier protein domain; Region: SCP2_2; pfam13530 226186010263 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 226186010264 LrgB-like family; Region: LrgB; pfam04172 226186010265 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 226186010266 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 226186010267 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 226186010268 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226186010269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186010270 active site 226186010271 hypothetical protein; Reviewed; Region: PRK00024 226186010272 Protein of unknown function (DUF3767); Region: DUF3767; pfam12597 226186010273 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 226186010274 MPN+ (JAMM) motif; other site 226186010275 Zinc-binding site [ion binding]; other site 226186010276 Domain of unknown function DUF59; Region: DUF59; cl00941 226186010277 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 226186010278 putative active site [active] 226186010279 putative metal binding site [ion binding]; other site 226186010280 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 226186010281 Ca binding site [ion binding]; other site 226186010282 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 226186010283 active site 226186010284 Carbohydrate-binding module 58 from Bacteroides thetaiotaomicron SusG and similar CBMs; Region: CBM58_SusG; cd12961 226186010285 starch binding site [chemical binding]; other site 226186010286 catalytic site [active] 226186010287 carbohydrate-binding module Fa from Bacteroides thetaiotaomicron SusE, and similar CBMs; Region: CBM-Fa; cd12964 226186010288 starch binding site [chemical binding]; other site 226186010289 carbohydrate-binding modules Eb and Fb from SusE and SusF, respectively, and similar CBMs; Region: CBM-Eb_CBM-Fb; cd12965 226186010290 starch binding site [chemical binding]; other site 226186010291 carbohydrate-binding modules Ec and Fc from SusE and SusF, respectively, and similar CBMs; Region: CBM-Ec_CBM-Fc; cd12966 226186010292 starch binding site [chemical binding]; other site 226186010293 starch-binding loop; other site 226186010294 SusE outer membrane protein; Region: SusE; pfam14292 226186010295 carbohydrate-binding modules Eb and Fb from SusE and SusF, respectively, and similar CBMs; Region: CBM-Eb_CBM-Fb; cd12965 226186010296 starch binding site [chemical binding]; other site 226186010297 carbohydrate-binding modules Ec and Fc from SusE and SusF, respectively, and similar CBMs; Region: CBM-Ec_CBM-Fc; cd12966 226186010298 starch binding site [chemical binding]; other site 226186010299 starch-binding loop; other site 226186010300 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186010301 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010302 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010303 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010304 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010305 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186010306 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186010307 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186010308 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 226186010309 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 226186010310 Ca binding site [ion binding]; other site 226186010311 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 226186010312 active site 226186010313 homodimer interface [polypeptide binding]; other site 226186010314 catalytic site [active] 226186010315 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 226186010316 Integrase core domain; Region: rve; pfam00665 226186010317 Integrase core domain; Region: rve_3; pfam13683 226186010318 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 226186010319 dimer interface [polypeptide binding]; other site 226186010320 active site 226186010321 elongation factor P; Validated; Region: PRK00529 226186010322 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 226186010323 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 226186010324 RNA binding site [nucleotide binding]; other site 226186010325 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 226186010326 RNA binding site [nucleotide binding]; other site 226186010327 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 226186010328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 226186010329 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226186010330 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226186010331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226186010332 RNA binding surface [nucleotide binding]; other site 226186010333 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226186010334 active site 226186010335 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 226186010336 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226186010337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186010338 NigD-like protein; Region: NigD; pfam12667 226186010339 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226186010340 active site residue [active] 226186010341 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 226186010342 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226186010343 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226186010344 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 226186010345 putative catalytic cysteine [active] 226186010346 gamma-glutamyl kinase; Provisional; Region: PRK05429 226186010347 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 226186010348 nucleotide binding site [chemical binding]; other site 226186010349 homotetrameric interface [polypeptide binding]; other site 226186010350 putative phosphate binding site [ion binding]; other site 226186010351 putative allosteric binding site; other site 226186010352 PUA domain; Region: PUA; pfam01472 226186010353 aspartate aminotransferase; Provisional; Region: PRK05764 226186010354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186010355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186010356 homodimer interface [polypeptide binding]; other site 226186010357 catalytic residue [active] 226186010358 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 226186010359 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226186010360 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 226186010361 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 226186010362 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 226186010363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 226186010364 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 226186010365 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 226186010366 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 226186010367 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 226186010368 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186010369 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 226186010370 active site 226186010371 dimer interface [polypeptide binding]; other site 226186010372 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 226186010373 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 226186010374 catalytic motif [active] 226186010375 Zn binding site [ion binding]; other site 226186010376 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 226186010377 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 226186010378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186010379 S-adenosylmethionine binding site [chemical binding]; other site 226186010380 RecX family; Region: RecX; pfam02631 226186010381 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186010382 active site 226186010383 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 226186010384 hydrophobic ligand binding site; other site 226186010385 Lyase; Region: Lyase_1; pfam00206 226186010386 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 226186010387 active sites [active] 226186010388 tetramer interface [polypeptide binding]; other site 226186010389 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 226186010390 FAD dependent oxidoreductase; Region: DAO; pfam01266 226186010391 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186010392 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186010393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186010394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010395 dimer interface [polypeptide binding]; other site 226186010396 phosphorylation site [posttranslational modification] 226186010397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010398 ATP binding site [chemical binding]; other site 226186010399 Mg2+ binding site [ion binding]; other site 226186010400 G-X-G motif; other site 226186010401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186010402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010403 active site 226186010404 phosphorylation site [posttranslational modification] 226186010405 intermolecular recognition site; other site 226186010406 dimerization interface [polypeptide binding]; other site 226186010407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010409 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 226186010410 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 226186010411 transmembrane helices; other site 226186010412 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 226186010413 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186010414 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 226186010415 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186010416 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 226186010417 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186010418 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186010419 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 226186010420 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 226186010421 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186010422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186010423 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186010424 DNA binding residues [nucleotide binding] 226186010425 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186010426 FecR protein; Region: FecR; pfam04773 226186010427 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186010428 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010429 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010430 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010431 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186010432 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186010433 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186010434 active site 226186010435 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186010436 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186010437 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186010438 Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; Region: MACS_AAE_MA_like; cd05970 226186010439 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 226186010440 active site 226186010441 acyl-activating enzyme (AAE) consensus motif; other site 226186010442 putative CoA binding site [chemical binding]; other site 226186010443 AMP binding site [chemical binding]; other site 226186010444 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226186010445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186010446 non-specific DNA binding site [nucleotide binding]; other site 226186010447 salt bridge; other site 226186010448 sequence-specific DNA binding site [nucleotide binding]; other site 226186010449 Cupin domain; Region: Cupin_2; pfam07883 226186010450 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 226186010451 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226186010452 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226186010453 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226186010454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226186010455 inhibitor-cofactor binding pocket; inhibition site 226186010456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186010457 catalytic residue [active] 226186010458 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 226186010459 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 226186010460 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 226186010461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 226186010462 Ligand Binding Site [chemical binding]; other site 226186010463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186010464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186010465 Coenzyme A binding pocket [chemical binding]; other site 226186010466 Arginine repressor [Transcription]; Region: ArgR; COG1438 226186010467 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226186010468 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226186010469 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 226186010470 N- and C-terminal domain interface [polypeptide binding]; other site 226186010471 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 226186010472 active site 226186010473 putative catalytic site [active] 226186010474 metal binding site [ion binding]; metal-binding site 226186010475 ATP binding site [chemical binding]; other site 226186010476 carbohydrate binding site [chemical binding]; other site 226186010477 L-rhamnose isomerase; Provisional; Region: PRK01076 226186010478 rhamnose-proton symporter; Provisional; Region: PRK13499 226186010479 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 226186010480 intersubunit interface [polypeptide binding]; other site 226186010481 active site 226186010482 Zn2+ binding site [ion binding]; other site 226186010483 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 226186010484 dimer interface [polypeptide binding]; other site 226186010485 active site 226186010486 metal binding site [ion binding]; metal-binding site 226186010487 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186010488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010491 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 226186010492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226186010493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226186010494 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226186010495 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 226186010496 NAD(P) binding site [chemical binding]; other site 226186010497 homotetramer interface [polypeptide binding]; other site 226186010498 homodimer interface [polypeptide binding]; other site 226186010499 active site 226186010500 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226186010501 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226186010502 active site 226186010503 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186010504 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186010505 alpha-mannosidase; Provisional; Region: PRK09819 226186010506 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 226186010507 active site 226186010508 catalytic site [active] 226186010509 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 226186010510 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 226186010511 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186010512 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 226186010513 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 226186010514 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 226186010515 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 226186010516 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 226186010517 active site 226186010518 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 226186010519 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 226186010520 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 226186010521 putative catalytic site [active] 226186010522 putative metal binding site [ion binding]; other site 226186010523 putative phosphate binding site [ion binding]; other site 226186010524 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186010525 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186010526 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186010527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186010528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010529 dimer interface [polypeptide binding]; other site 226186010530 phosphorylation site [posttranslational modification] 226186010531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010532 ATP binding site [chemical binding]; other site 226186010533 Mg2+ binding site [ion binding]; other site 226186010534 G-X-G motif; other site 226186010535 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 226186010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010537 active site 226186010538 phosphorylation site [posttranslational modification] 226186010539 intermolecular recognition site; other site 226186010540 dimerization interface [polypeptide binding]; other site 226186010541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010543 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186010544 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010545 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010546 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010547 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010548 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186010549 SusD family; Region: SusD; pfam07980 226186010550 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186010551 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 226186010552 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 226186010553 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186010554 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 226186010555 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186010556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186010557 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186010558 arylsulfatase; Provisional; Region: PRK13759 226186010559 Sulfatase; Region: Sulfatase; pfam00884 226186010560 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 226186010561 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 226186010562 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186010563 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186010564 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186010565 Sulfatase; Region: Sulfatase; pfam00884 226186010566 Two component regulator propeller; Region: Reg_prop; pfam07494 226186010567 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186010568 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186010569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186010570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010571 dimer interface [polypeptide binding]; other site 226186010572 phosphorylation site [posttranslational modification] 226186010573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010574 ATP binding site [chemical binding]; other site 226186010575 Mg2+ binding site [ion binding]; other site 226186010576 G-X-G motif; other site 226186010577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186010578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010579 active site 226186010580 phosphorylation site [posttranslational modification] 226186010581 intermolecular recognition site; other site 226186010582 dimerization interface [polypeptide binding]; other site 226186010583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186010584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186010585 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 226186010586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010587 active site 226186010588 phosphorylation site [posttranslational modification] 226186010589 intermolecular recognition site; other site 226186010590 dimerization interface [polypeptide binding]; other site 226186010591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186010592 Walker A motif; other site 226186010593 ATP binding site [chemical binding]; other site 226186010594 Walker B motif; other site 226186010595 arginine finger; other site 226186010596 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186010597 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 226186010598 active site 226186010599 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186010600 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226186010601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186010602 multidrug efflux protein; Reviewed; Region: PRK01766 226186010603 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 226186010604 cation binding site [ion binding]; other site 226186010605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186010606 dimer interface [polypeptide binding]; other site 226186010607 phosphorylation site [posttranslational modification] 226186010608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010609 ATP binding site [chemical binding]; other site 226186010610 Mg2+ binding site [ion binding]; other site 226186010611 G-X-G motif; other site 226186010612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186010613 active site 226186010614 phosphorylation site [posttranslational modification] 226186010615 intermolecular recognition site; other site 226186010616 dimerization interface [polypeptide binding]; other site 226186010617 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226186010618 Family of unknown function (DUF490); Region: DUF490; pfam04357 226186010619 Surface antigen; Region: Bac_surface_Ag; pfam01103 226186010620 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226186010621 active site 226186010622 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226186010623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186010624 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 226186010625 ABC transporter; Region: ABC_tran_2; pfam12848 226186010626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226186010627 Peptidase family M13; Region: Peptidase_M13_N; pfam05649 226186010628 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 226186010629 active site 226186010630 Zn binding site [ion binding]; other site 226186010631 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 226186010632 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 226186010633 purine monophosphate binding site [chemical binding]; other site 226186010634 dimer interface [polypeptide binding]; other site 226186010635 putative catalytic residues [active] 226186010636 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 226186010637 rod shape-determining protein MreB; Provisional; Region: PRK13927 226186010638 MreB and similar proteins; Region: MreB_like; cd10225 226186010639 nucleotide binding site [chemical binding]; other site 226186010640 Mg binding site [ion binding]; other site 226186010641 putative protofilament interaction site [polypeptide binding]; other site 226186010642 RodZ interaction site [polypeptide binding]; other site 226186010643 rod shape-determining protein MreC; Provisional; Region: PRK13922 226186010644 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 226186010645 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226186010646 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226186010647 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226186010648 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226186010649 gliding motility-associated lipoprotein GldH; Region: GldH_lipo; TIGR03511 226186010650 PSP1 C-terminal conserved region; Region: PSP1; cl00770 226186010651 Proline-rich; Region: Pro-rich; pfam15240 226186010652 Nucleocapsid protein N; Region: Nucleocapsid-N; pfam11030 226186010653 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 226186010654 DNA polymerase III subunit delta'; Validated; Region: PRK08485 226186010655 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 226186010656 FAD binding site [chemical binding]; other site 226186010657 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 226186010658 Ferritin-like domain; Region: Ferritin; pfam00210 226186010659 diiron binding motif [ion binding]; other site 226186010660 Integrase core domain; Region: rve; pfam00665 226186010661 Integrase core domain; Region: rve_3; pfam13683 226186010662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186010663 TPR motif; other site 226186010664 binding surface 226186010665 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 226186010666 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226186010667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186010668 S-adenosylmethionine binding site [chemical binding]; other site 226186010669 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 226186010670 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 226186010671 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 226186010672 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226186010673 dimer interface [polypeptide binding]; other site 226186010674 active site 226186010675 CoA binding pocket [chemical binding]; other site 226186010676 GTPase Era; Reviewed; Region: era; PRK00089 226186010677 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 226186010678 G1 box; other site 226186010679 GTP/Mg2+ binding site [chemical binding]; other site 226186010680 Switch I region; other site 226186010681 G2 box; other site 226186010682 Switch II region; other site 226186010683 G3 box; other site 226186010684 G4 box; other site 226186010685 G5 box; other site 226186010686 KH domain; Region: KH_2; pfam07650 226186010687 GTP-binding protein Der; Reviewed; Region: PRK00093 226186010688 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 226186010689 G1 box; other site 226186010690 GTP/Mg2+ binding site [chemical binding]; other site 226186010691 Switch I region; other site 226186010692 G2 box; other site 226186010693 Switch II region; other site 226186010694 G3 box; other site 226186010695 G4 box; other site 226186010696 G5 box; other site 226186010697 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 226186010698 G1 box; other site 226186010699 GTP/Mg2+ binding site [chemical binding]; other site 226186010700 Switch I region; other site 226186010701 G2 box; other site 226186010702 G3 box; other site 226186010703 Switch II region; other site 226186010704 G4 box; other site 226186010705 G5 box; other site 226186010706 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 226186010707 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 226186010708 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 226186010709 Walker A/P-loop; other site 226186010710 ATP binding site [chemical binding]; other site 226186010711 Q-loop/lid; other site 226186010712 ABC transporter signature motif; other site 226186010713 Walker B; other site 226186010714 D-loop; other site 226186010715 H-loop/switch region; other site 226186010716 Permease; Region: Permease; pfam02405 226186010717 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 226186010718 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 226186010719 Walker A/P-loop; other site 226186010720 ATP binding site [chemical binding]; other site 226186010721 Q-loop/lid; other site 226186010722 ABC transporter signature motif; other site 226186010723 Walker B; other site 226186010724 D-loop; other site 226186010725 H-loop/switch region; other site 226186010726 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 226186010727 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 226186010728 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 226186010729 trigger factor; Region: tig; TIGR00115 226186010730 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226186010731 oligomer interface [polypeptide binding]; other site 226186010732 active site residues [active] 226186010733 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 226186010734 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 226186010735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186010736 Walker A motif; other site 226186010737 ATP binding site [chemical binding]; other site 226186010738 Walker B motif; other site 226186010739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226186010740 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 226186010741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186010742 ATP binding site [chemical binding]; other site 226186010743 putative Mg++ binding site [ion binding]; other site 226186010744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186010745 nucleotide binding region [chemical binding]; other site 226186010746 ATP-binding site [chemical binding]; other site 226186010747 RQC domain; Region: RQC; pfam09382 226186010748 HRDC domain; Region: HRDC; pfam00570 226186010749 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 226186010750 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 226186010751 active site 226186010752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 226186010753 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226186010754 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 226186010755 SurA N-terminal domain; Region: SurA_N_3; cl07813 226186010756 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 226186010757 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226186010758 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226186010759 OstA-like protein; Region: OstA_2; pfam13100 226186010760 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 226186010761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186010762 ATP binding site [chemical binding]; other site 226186010763 Mg2+ binding site [ion binding]; other site 226186010764 G-X-G motif; other site 226186010765 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 226186010766 ATP binding site [chemical binding]; other site 226186010767 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 226186010768 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010769 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186010770 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186010771 ligand binding site [chemical binding]; other site 226186010772 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186010773 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010774 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186010775 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186010776 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186010777 SusD family; Region: SusD; pfam07980 226186010778 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 226186010779 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 226186010780 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186010781 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 226186010782 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186010783 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186010784 Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase; Region: GH99; cd11574 226186010785 ligand binding site [chemical binding]; other site 226186010786 putative catalytic site [active] 226186010787 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 226186010788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 226186010789 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 226186010790 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 226186010791 active site 226186010792 HIGH motif; other site 226186010793 dimer interface [polypeptide binding]; other site 226186010794 KMSKS motif; other site 226186010795 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 226186010796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186010797 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226186010798 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 226186010799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226186010800 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226186010801 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 226186010802 probable substrate binding site [chemical binding]; other site 226186010803 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186010804 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 226186010805 active site 226186010806 hypothetical protein; Validated; Region: PRK02101 226186010807 maltose O-acetyltransferase; Provisional; Region: PRK10092 226186010808 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226186010809 active site 226186010810 substrate binding site [chemical binding]; other site 226186010811 trimer interface [polypeptide binding]; other site 226186010812 CoA binding site [chemical binding]; other site 226186010813 adenylosuccinate lyase; Provisional; Region: PRK09285 226186010814 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 226186010815 tetramer interface [polypeptide binding]; other site 226186010816 active site 226186010817 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226186010818 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226186010819 RNA binding surface [nucleotide binding]; other site 226186010820 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 226186010821 active site 226186010822 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 226186010823 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 226186010824 putative dimer interface [polypeptide binding]; other site 226186010825 putative anticodon binding site; other site 226186010826 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226186010827 homodimer interface [polypeptide binding]; other site 226186010828 motif 1; other site 226186010829 motif 2; other site 226186010830 active site 226186010831 motif 3; other site 226186010832 Domain of unknown function (DUF4488); Region: DUF4488; pfam14869 226186010833 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 226186010834 23S rRNA interface [nucleotide binding]; other site 226186010835 L3 interface [polypeptide binding]; other site 226186010836 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 226186010837 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 226186010838 rRNA interaction site [nucleotide binding]; other site 226186010839 S8 interaction site; other site 226186010840 putative laminin-1 binding site; other site 226186010841 elongation factor Ts; Provisional; Region: tsf; PRK09377 226186010842 UBA/TS-N domain; Region: UBA; pfam00627 226186010843 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 226186010844 putative rRNA binding site [nucleotide binding]; other site 226186010845 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186010846 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 226186010847 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 226186010848 CoA binding domain; Region: CoA_binding; pfam02629 226186010849 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 226186010850 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 226186010851 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 226186010852 homotrimer interaction site [polypeptide binding]; other site 226186010853 zinc binding site [ion binding]; other site 226186010854 CDP-binding sites; other site 226186010855 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 226186010856 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186010857 putative active site [active] 226186010858 putative metal binding site [ion binding]; other site 226186010859 exodeoxyribonuclease X; Provisional; Region: PRK07983 226186010860 tRNA-specific 2-thiouridylase MnmA; Provisional; Region: PRK14664 226186010861 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226186010862 Ligand Binding Site [chemical binding]; other site 226186010863 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 226186010864 Subtilase family; Region: Peptidase_S8; pfam00082 226186010865 active site 226186010866 catalytic triad [active] 226186010867 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 226186010868 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 226186010869 generic binding surface II; other site 226186010870 generic binding surface I; other site 226186010871 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 226186010872 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 226186010873 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 226186010874 homodimer interface [polypeptide binding]; other site 226186010875 substrate-cofactor binding pocket; other site 226186010876 catalytic residue [active] 226186010877 Protein of unknown function (DUF975); Region: DUF975; cl10504 226186010878 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226186010879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186010880 S-adenosylmethionine binding site [chemical binding]; other site 226186010881 Domain of unknown function DUF59; Region: DUF59; pfam01883 226186010882 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 226186010883 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 226186010884 Walker A motif; other site 226186010885 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186010886 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186010887 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226186010888 catalytic residues [active] 226186010889 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186010890 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186010891 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186010892 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186010893 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 226186010894 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226186010895 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226186010896 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226186010897 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 226186010898 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226186010899 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226186010900 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 226186010901 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186010902 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186010903 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186010904 Outer membrane efflux protein; Region: OEP; pfam02321 226186010905 Outer membrane efflux protein; Region: OEP; pfam02321 226186010906 SWIM zinc finger; Region: SWIM; pfam04434 226186010907 MoxR-like ATPases [General function prediction only]; Region: COG0714 226186010908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186010909 Walker A motif; other site 226186010910 ATP binding site [chemical binding]; other site 226186010911 Walker B motif; other site 226186010912 arginine finger; other site 226186010913 Arabidopsis broad-spectrum mildew resistance protein RPW8; Region: RPW8; pfam05659 226186010914 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 226186010915 metal ion-dependent adhesion site (MIDAS); other site 226186010916 malate dehydrogenase; Reviewed; Region: PRK06223 226186010917 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 226186010918 NAD(P) binding site [chemical binding]; other site 226186010919 dimer interface [polypeptide binding]; other site 226186010920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226186010921 substrate binding site [chemical binding]; other site 226186010922 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 226186010923 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 226186010924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186010925 active site 226186010926 DNA binding site [nucleotide binding] 226186010927 Int/Topo IB signature motif; other site 226186010928 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 226186010929 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 226186010930 active site 226186010931 hydrophilic channel; other site 226186010932 dimerization interface [polypeptide binding]; other site 226186010933 catalytic residues [active] 226186010934 active site lid [active] 226186010935 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 226186010936 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 226186010937 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 226186010938 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048 226186010939 DJ-1 family protein; Region: not_thiJ; TIGR01383 226186010940 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 226186010941 conserved cys residue [active] 226186010942 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226186010943 substrate binding site; other site 226186010944 dimer interface; other site 226186010945 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 226186010946 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 226186010947 generic binding surface II; other site 226186010948 ssDNA binding site; other site 226186010949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186010950 ATP binding site [chemical binding]; other site 226186010951 putative Mg++ binding site [ion binding]; other site 226186010952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186010953 nucleotide binding region [chemical binding]; other site 226186010954 ATP-binding site [chemical binding]; other site 226186010955 Nucleoside diphosphate kinase; Region: NDK; pfam00334 226186010956 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 226186010957 active site 226186010958 multimer interface [polypeptide binding]; other site 226186010959 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226186010960 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186010961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186010962 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 226186010963 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 226186010964 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 226186010965 substrate binding site [chemical binding]; other site 226186010966 dimer interface [polypeptide binding]; other site 226186010967 catalytic triad [active] 226186010968 Sporulation related domain; Region: SPOR; pfam05036 226186010969 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 226186010970 active site 226186010971 DNA primase, catalytic core; Region: dnaG; TIGR01391 226186010972 CHC2 zinc finger; Region: zf-CHC2; pfam01807 226186010973 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 226186010974 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 226186010975 active site 226186010976 metal binding site [ion binding]; metal-binding site 226186010977 interdomain interaction site; other site 226186010978 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 226186010979 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 226186010980 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226186010981 prephenate dehydrogenase; Validated; Region: PRK08507 226186010982 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 226186010983 Chorismate mutase type II; Region: CM_2; pfam01817 226186010984 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 226186010985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186010986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186010987 homodimer interface [polypeptide binding]; other site 226186010988 catalytic residue [active] 226186010989 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 226186010990 Prephenate dehydratase; Region: PDT; pfam00800 226186010991 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 226186010992 putative L-Phe binding site [chemical binding]; other site 226186010993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186010994 binding surface 226186010995 TPR motif; other site 226186010996 TPR repeat; Region: TPR_11; pfam13414 226186010997 TPR repeat; Region: TPR_11; pfam13414 226186010998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186010999 binding surface 226186011000 TPR motif; other site 226186011001 TPR repeat; Region: TPR_11; pfam13414 226186011002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186011003 binding surface 226186011004 TPR motif; other site 226186011005 TPR repeat; Region: TPR_11; pfam13414 226186011006 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186011007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186011008 ATP binding site [chemical binding]; other site 226186011009 putative Mg++ binding site [ion binding]; other site 226186011010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186011011 nucleotide binding region [chemical binding]; other site 226186011012 ATP-binding site [chemical binding]; other site 226186011013 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 226186011014 DHH family; Region: DHH; pfam01368 226186011015 DHHA1 domain; Region: DHHA1; pfam02272 226186011016 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 226186011017 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226186011018 active site 226186011019 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 226186011020 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 226186011021 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 226186011022 Cl- selectivity filter; other site 226186011023 Cl- binding residues [ion binding]; other site 226186011024 pore gating glutamate residue; other site 226186011025 dimer interface [polypeptide binding]; other site 226186011026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 226186011027 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 226186011028 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 226186011029 putative active site [active] 226186011030 substrate binding site [chemical binding]; other site 226186011031 putative cosubstrate binding site; other site 226186011032 catalytic site [active] 226186011033 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 226186011034 substrate binding site [chemical binding]; other site 226186011035 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 226186011036 substrate binding site [chemical binding]; other site 226186011037 hexamer interface [polypeptide binding]; other site 226186011038 metal binding site [ion binding]; metal-binding site 226186011039 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 226186011040 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 226186011041 Competence protein; Region: Competence; pfam03772 226186011042 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 226186011043 DHH family; Region: DHH; pfam01368 226186011044 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 226186011045 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 226186011046 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 226186011047 active site 226186011048 substrate binding site [chemical binding]; other site 226186011049 metal binding site [ion binding]; metal-binding site 226186011050 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011052 active site 226186011053 phosphorylation site [posttranslational modification] 226186011054 dimerization interface [polypeptide binding]; other site 226186011055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011058 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011059 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011061 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186011062 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011063 SusD family; Region: SusD; pfam07980 226186011064 Peptidase of plants and bacteria; Region: BSP; pfam04450 226186011065 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 226186011066 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186011067 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186011068 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011069 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011070 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011071 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 226186011072 active site 226186011073 phosphorylation site [posttranslational modification] 226186011074 dimerization interface [polypeptide binding]; other site 226186011075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011077 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011078 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011079 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011080 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011081 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011082 SusD family; Region: SusD; pfam07980 226186011083 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011084 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 226186011085 catalytic site [active] 226186011086 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 226186011087 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011088 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011089 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011090 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011091 Peptidase of plants and bacteria; Region: BSP; pfam04450 226186011092 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011093 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011094 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186011095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011096 active site 226186011097 phosphorylation site [posttranslational modification] 226186011098 intermolecular recognition site; other site 226186011099 dimerization interface [polypeptide binding]; other site 226186011100 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186011101 Histidine kinase; Region: His_kinase; pfam06580 226186011102 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226186011103 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186011104 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 226186011105 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186011106 Outer membrane efflux protein; Region: OEP; pfam02321 226186011107 Outer membrane efflux protein; Region: OEP; pfam02321 226186011108 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 226186011109 catalytic residues [active] 226186011110 dimer interface [polypeptide binding]; other site 226186011111 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 226186011112 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 226186011113 nudix motif; other site 226186011114 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 226186011115 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186011116 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 226186011117 active site 226186011118 dimer interface [polypeptide binding]; other site 226186011119 metal binding site [ion binding]; metal-binding site 226186011120 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011121 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186011122 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186011123 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 226186011124 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 226186011125 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226186011126 putative active site [active] 226186011127 catalytic site [active] 226186011128 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226186011129 putative active site [active] 226186011130 catalytic site [active] 226186011131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186011132 S-adenosylmethionine binding site [chemical binding]; other site 226186011133 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 226186011134 AAA domain; Region: AAA_30; pfam13604 226186011135 AAA domain; Region: AAA_11; pfam13086 226186011136 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226186011137 Secretin and TonB N terminus short domain; Region: STN; smart00965 226186011138 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011139 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011141 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186011142 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011143 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186011144 active site 226186011145 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011146 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186011147 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011148 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186011149 active site 226186011150 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 226186011151 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011152 sugar binding site [chemical binding]; other site 226186011153 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011154 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011155 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011156 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011157 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186011158 FecR protein; Region: FecR; pfam04773 226186011159 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186011160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186011161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186011162 DNA binding residues [nucleotide binding] 226186011163 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011164 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011165 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 226186011166 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 226186011167 motif 1; other site 226186011168 active site 226186011169 motif 2; other site 226186011170 motif 3; other site 226186011171 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226186011172 DHHA1 domain; Region: DHHA1; pfam02272 226186011173 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226186011174 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186011175 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226186011176 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 226186011177 DNA binding residues [nucleotide binding] 226186011178 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226186011179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186011180 Zn2+ binding site [ion binding]; other site 226186011181 Mg2+ binding site [ion binding]; other site 226186011182 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226186011183 synthetase active site [active] 226186011184 NTP binding site [chemical binding]; other site 226186011185 metal binding site [ion binding]; metal-binding site 226186011186 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 226186011187 ACT domain; Region: ACT_4; pfam13291 226186011188 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 226186011189 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226186011190 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226186011191 catalytic residue [active] 226186011192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226186011193 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 226186011194 ParB-like nuclease domain; Region: ParBc; pfam02195 226186011195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226186011196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186011197 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 226186011198 P-loop; other site 226186011199 Magnesium ion binding site [ion binding]; other site 226186011200 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 226186011201 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 226186011202 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 226186011203 NigD-like protein; Region: NigD; pfam12667 226186011204 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 226186011205 FtsH Extracellular; Region: FtsH_ext; pfam06480 226186011206 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 226186011207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186011208 Walker A motif; other site 226186011209 ATP binding site [chemical binding]; other site 226186011210 Walker B motif; other site 226186011211 arginine finger; other site 226186011212 Peptidase family M41; Region: Peptidase_M41; pfam01434 226186011213 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 226186011214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186011215 active site 226186011216 Int/Topo IB signature motif; other site 226186011217 DNA binding site [nucleotide binding] 226186011218 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 226186011219 Q-loop/lid; other site 226186011220 AAA domain; Region: AAA_21; pfam13304 226186011221 Walker B; other site 226186011222 D-loop; other site 226186011223 H-loop/switch region; other site 226186011224 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186011225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186011226 ATP binding site [chemical binding]; other site 226186011227 putative Mg++ binding site [ion binding]; other site 226186011228 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226186011229 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186011230 active site 226186011231 DNA binding site [nucleotide binding] 226186011232 Int/Topo IB signature motif; other site 226186011233 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186011234 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 226186011235 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186011236 Int/Topo IB signature motif; other site 226186011237 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186011238 Int/Topo IB signature motif; other site 226186011239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186011240 active site 226186011241 Int/Topo IB signature motif; other site 226186011242 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186011243 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 226186011244 Domain of unknown function (DUF4248); Region: DUF4248; pfam14053 226186011245 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186011246 amidase catalytic site [active] 226186011247 Zn binding residues [ion binding]; other site 226186011248 substrate binding site [chemical binding]; other site 226186011249 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186011250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186011251 salt bridge; other site 226186011252 non-specific DNA binding site [nucleotide binding]; other site 226186011253 sequence-specific DNA binding site [nucleotide binding]; other site 226186011254 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011255 SusD family; Region: SusD; pfam07980 226186011256 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011257 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011258 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011259 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011260 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011261 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011262 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011263 sugar binding site [chemical binding]; other site 226186011264 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 226186011265 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 226186011266 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 226186011267 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 226186011268 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 226186011269 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 226186011270 MgtE intracellular N domain; Region: MgtE_N; smart00924 226186011271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 226186011272 Divalent cation transporter; Region: MgtE; pfam01769 226186011273 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 226186011274 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 226186011275 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 226186011276 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 226186011277 metal binding site [ion binding]; metal-binding site 226186011278 dimer interface [polypeptide binding]; other site 226186011279 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186011280 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186011281 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 226186011282 MG2 domain; Region: A2M_N; pfam01835 226186011283 Alpha-2-macroglobulin family; Region: A2M; pfam00207 226186011284 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 226186011285 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 226186011286 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 226186011287 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 226186011288 Walker A; other site 226186011289 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226186011290 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011291 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011292 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186011293 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186011294 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 226186011295 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011296 sugar binding site [chemical binding]; other site 226186011297 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186011298 EamA-like transporter family; Region: EamA; pfam00892 226186011299 EamA-like transporter family; Region: EamA; pfam00892 226186011300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186011301 Walker A/P-loop; other site 226186011302 ATP binding site [chemical binding]; other site 226186011303 AAA domain; Region: AAA_21; pfam13304 226186011304 ABC transporter signature motif; other site 226186011305 Walker B; other site 226186011306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186011307 D-loop; other site 226186011308 H-loop/switch region; other site 226186011309 Protein of unknown function (DUF4435); Region: DUF4435; pfam14491 226186011310 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186011311 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226186011312 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186011313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011314 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011315 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 226186011316 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011317 GAF domain; Region: GAF; pfam01590 226186011318 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 226186011319 PAS domain; Region: PAS_8; pfam13188 226186011320 PAS fold; Region: PAS_3; pfam08447 226186011321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011322 dimer interface [polypeptide binding]; other site 226186011323 phosphorylation site [posttranslational modification] 226186011324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011325 ATP binding site [chemical binding]; other site 226186011326 Mg2+ binding site [ion binding]; other site 226186011327 G-X-G motif; other site 226186011328 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 226186011329 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226186011330 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 226186011331 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226186011332 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 226186011333 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 226186011334 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226186011335 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 226186011336 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 226186011337 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 226186011338 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 226186011339 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226186011340 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 226186011341 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 226186011342 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 226186011343 NADH dehydrogenase subunit D; Validated; Region: PRK06075 226186011344 NADH dehydrogenase subunit B; Provisional; Region: PRK14816 226186011345 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 226186011346 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186011347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186011348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186011349 DNA binding residues [nucleotide binding] 226186011350 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 226186011351 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 226186011352 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 226186011353 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011354 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011355 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011356 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011357 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186011358 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011359 sugar binding site [chemical binding]; other site 226186011360 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 226186011361 active site 226186011362 catalytic triad [active] 226186011363 oxyanion hole [active] 226186011364 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 226186011365 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 226186011366 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 226186011367 Putative esterase; Region: Esterase; pfam00756 226186011368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 226186011369 sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827 226186011370 active site 226186011371 catalytic triad [active] 226186011372 oxyanion hole [active] 226186011373 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186011374 NHL repeat; Region: NHL; pfam01436 226186011375 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011376 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011377 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011378 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186011379 SusD family; Region: SusD; pfam07980 226186011380 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011381 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186011382 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011383 SusD family; Region: SusD; pfam07980 226186011384 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011385 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011386 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186011387 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011388 SusD family; Region: SusD; pfam07980 226186011389 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011390 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011391 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011392 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011393 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186011394 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011395 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011396 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011397 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 226186011398 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 226186011399 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 226186011400 active site 226186011401 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 226186011402 putative substrate binding site [chemical binding]; other site 226186011403 active site 226186011404 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 226186011405 active site 226186011406 catalytic triad [active] 226186011407 oxyanion hole [active] 226186011408 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 226186011409 Cation transport protein; Region: TrkH; cl17365 226186011410 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 226186011411 TrkA-N domain; Region: TrkA_N; pfam02254 226186011412 TrkA-C domain; Region: TrkA_C; pfam02080 226186011413 TrkA-N domain; Region: TrkA_N; pfam02254 226186011414 TrkA-C domain; Region: TrkA_C; pfam02080 226186011415 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 226186011416 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 226186011417 TPP-binding site; other site 226186011418 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226186011419 PYR/PP interface [polypeptide binding]; other site 226186011420 dimer interface [polypeptide binding]; other site 226186011421 TPP binding site [chemical binding]; other site 226186011422 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226186011423 GSCFA family; Region: GSCFA; pfam08885 226186011424 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226186011425 catalytic triad [active] 226186011426 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 226186011427 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226186011428 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226186011429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226186011430 active site 226186011431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226186011432 dimer interface [polypeptide binding]; other site 226186011433 substrate binding site [chemical binding]; other site 226186011434 catalytic residues [active] 226186011435 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 226186011436 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 226186011437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226186011438 AAA domain; Region: AAA_11; pfam13086 226186011439 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186011440 ATP binding site [chemical binding]; other site 226186011441 putative Mg++ binding site [ion binding]; other site 226186011442 AAA domain; Region: AAA_12; pfam13087 226186011443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186011444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186011445 putative substrate translocation pore; other site 226186011446 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 226186011447 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 226186011448 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186011449 Pectinesterase; Region: Pectinesterase; cl01911 226186011450 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 226186011451 active site 226186011452 catalytic triad [active] 226186011453 Pectinesterase; Region: Pectinesterase; cl01911 226186011454 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011455 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011456 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011459 dimer interface [polypeptide binding]; other site 226186011460 phosphorylation site [posttranslational modification] 226186011461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011462 ATP binding site [chemical binding]; other site 226186011463 Mg2+ binding site [ion binding]; other site 226186011464 G-X-G motif; other site 226186011465 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186011466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011467 active site 226186011468 phosphorylation site [posttranslational modification] 226186011469 intermolecular recognition site; other site 226186011470 dimerization interface [polypeptide binding]; other site 226186011471 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226186011474 Interdomain contacts; other site 226186011475 Cytokine receptor motif; other site 226186011476 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186011477 SusD family; Region: SusD; pfam07980 226186011478 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011479 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011480 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011482 Pectate lyase; Region: Pec_lyase_C; cl01593 226186011483 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 226186011484 Pectate lyase; Region: Pec_lyase_C; cl01593 226186011485 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 226186011486 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186011487 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186011488 Pectate lyase; Region: Pec_lyase_C; cl01593 226186011489 Fibronectin type 3 domain; Region: FN3; smart00060 226186011490 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011491 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011492 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011493 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011494 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186011495 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186011496 SusD family; Region: SusD; pfam07980 226186011497 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226186011498 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011499 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011500 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011501 Two component regulator propeller; Region: Reg_prop; pfam07494 226186011502 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011505 dimer interface [polypeptide binding]; other site 226186011506 phosphorylation site [posttranslational modification] 226186011507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011508 ATP binding site [chemical binding]; other site 226186011509 Mg2+ binding site [ion binding]; other site 226186011510 G-X-G motif; other site 226186011511 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 226186011512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011513 active site 226186011514 phosphorylation site [posttranslational modification] 226186011515 intermolecular recognition site; other site 226186011516 dimerization interface [polypeptide binding]; other site 226186011517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011520 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 226186011521 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 226186011522 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 226186011523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226186011524 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 226186011525 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226186011526 active site 226186011527 trimer interface [polypeptide binding]; other site 226186011528 allosteric site; other site 226186011529 active site lid [active] 226186011530 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226186011531 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 226186011532 AsmA family; Region: AsmA; pfam05170 226186011533 Family of unknown function (DUF490); Region: DUF490; pfam04357 226186011534 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 226186011535 PIF1-like helicase; Region: PIF1; pfam05970 226186011536 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 226186011537 G1 box; other site 226186011538 GTP/Mg2+ binding site [chemical binding]; other site 226186011539 G2 box; other site 226186011540 Switch I region; other site 226186011541 Switch II region; other site 226186011542 G3 box; other site 226186011543 G5 box; other site 226186011544 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 226186011545 TPR repeat; Region: TPR_11; pfam13414 226186011546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186011547 binding surface 226186011548 TPR motif; other site 226186011549 TPR repeat; Region: TPR_11; pfam13414 226186011550 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186011551 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 226186011552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186011553 active site 226186011554 motif I; other site 226186011555 motif II; other site 226186011556 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186011557 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011558 sugar binding site [chemical binding]; other site 226186011559 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011560 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011561 SusD family; Region: SusD; pfam07980 226186011562 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011563 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011564 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011565 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186011566 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186011567 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011568 VID27 cytoplasmic protein; Region: VID27; cl19884 226186011569 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011572 dimer interface [polypeptide binding]; other site 226186011573 phosphorylation site [posttranslational modification] 226186011574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011575 ATP binding site [chemical binding]; other site 226186011576 Mg2+ binding site [ion binding]; other site 226186011577 G-X-G motif; other site 226186011578 two component system sensor kinase SsrB; Provisional; Region: PRK15369 226186011579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011580 active site 226186011581 phosphorylation site [posttranslational modification] 226186011582 intermolecular recognition site; other site 226186011583 dimerization interface [polypeptide binding]; other site 226186011584 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186011585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011586 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 226186011587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226186011588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226186011589 homodimer interface [polypeptide binding]; other site 226186011590 catalytic residue [active] 226186011591 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226186011592 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226186011593 putative active site [active] 226186011594 putative metal binding site [ion binding]; other site 226186011595 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226186011596 active site 226186011597 NTP binding site [chemical binding]; other site 226186011598 metal binding triad [ion binding]; metal-binding site 226186011599 antibiotic binding site [chemical binding]; other site 226186011600 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 226186011601 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226186011602 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226186011603 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 226186011604 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 226186011605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186011606 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226186011607 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 226186011608 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747 226186011609 homodimer interface [polypeptide binding]; other site 226186011610 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011611 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 226186011612 active site 226186011613 catalytic triad [active] 226186011614 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011615 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011616 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186011617 active site 226186011618 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 226186011619 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 226186011620 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 226186011621 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 226186011622 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011623 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 226186011624 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226186011625 putative active site [active] 226186011626 putative metal binding site [ion binding]; other site 226186011627 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226186011628 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011629 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011630 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011631 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011632 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186011633 alpha-galactosidase; Region: PLN02692 226186011634 alpha-galactosidase; Region: PLN02808; cl17638 226186011635 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 226186011636 Ca binding site [ion binding]; other site 226186011637 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226186011638 active site 226186011639 catalytic triad [active] 226186011640 oxyanion hole [active] 226186011641 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 226186011642 active site 226186011643 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 226186011644 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186011645 VirE N-terminal domain; Region: VirE_N; pfam08800 226186011646 Virulence-associated protein E; Region: VirE; pfam05272 226186011647 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186011648 Fasciclin domain; Region: Fasciclin; cl02663 226186011649 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011650 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011651 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011652 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011653 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011654 Fasciclin domain; Region: Fasciclin; pfam02469 226186011655 Fasciclin domain; Region: Fasciclin; cl02663 226186011656 Fasciclin domain; Region: Fasciclin; cl02663 226186011657 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011658 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011659 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011660 Right handed beta helix region; Region: Beta_helix; pfam13229 226186011661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186011662 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186011663 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186011664 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 226186011665 active site 226186011666 catalytic triad [active] 226186011667 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 226186011668 active site 226186011669 catalytic triad [active] 226186011670 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186011671 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 226186011672 metal binding site [ion binding]; metal-binding site 226186011673 active site 226186011674 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 226186011675 Domain of unknown function (DUF718); Region: DUF718; pfam05336 226186011676 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011677 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011680 dimer interface [polypeptide binding]; other site 226186011681 phosphorylation site [posttranslational modification] 226186011682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011683 ATP binding site [chemical binding]; other site 226186011684 Mg2+ binding site [ion binding]; other site 226186011685 G-X-G motif; other site 226186011686 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 226186011687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011688 active site 226186011689 phosphorylation site [posttranslational modification] 226186011690 intermolecular recognition site; other site 226186011691 dimerization interface [polypeptide binding]; other site 226186011692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011694 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186011695 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226186011696 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 226186011697 putative active site [active] 226186011698 putative metal binding site [ion binding]; other site 226186011699 Domain of unknown function (DUF303); Region: DUF303; pfam03629 226186011700 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011701 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011702 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186011703 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011704 Two component regulator propeller; Region: Reg_prop; pfam07494 226186011705 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186011706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186011708 dimer interface [polypeptide binding]; other site 226186011709 phosphorylation site [posttranslational modification] 226186011710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011711 ATP binding site [chemical binding]; other site 226186011712 Mg2+ binding site [ion binding]; other site 226186011713 G-X-G motif; other site 226186011714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226186011715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011716 active site 226186011717 phosphorylation site [posttranslational modification] 226186011718 intermolecular recognition site; other site 226186011719 dimerization interface [polypeptide binding]; other site 226186011720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186011721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186011722 Right handed beta helix region; Region: Beta_helix; pfam13229 226186011723 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226186011724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186011725 motif II; other site 226186011726 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 226186011727 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 226186011728 active site 226186011729 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 226186011730 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011731 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011732 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 226186011733 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 226186011734 NAD binding site [chemical binding]; other site 226186011735 homotetramer interface [polypeptide binding]; other site 226186011736 homodimer interface [polypeptide binding]; other site 226186011737 substrate binding site [chemical binding]; other site 226186011738 active site 226186011739 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 226186011740 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 226186011741 putative SAM binding site [chemical binding]; other site 226186011742 homodimer interface [polypeptide binding]; other site 226186011743 lipoyl synthase; Provisional; Region: PRK05481 226186011744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186011745 FeS/SAM binding site; other site 226186011746 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 226186011747 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226186011748 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186011749 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 226186011750 prohibitin homologues; Region: PHB; smart00244 226186011751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 226186011752 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226186011753 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186011754 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186011755 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186011756 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186011757 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226186011758 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186011759 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186011760 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011761 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 226186011762 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 226186011763 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 226186011764 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 226186011765 active site 226186011766 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 226186011767 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 226186011768 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226186011769 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 226186011770 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 226186011771 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 226186011772 trimer interface [polypeptide binding]; other site 226186011773 active site 226186011774 UDP-GlcNAc binding site [chemical binding]; other site 226186011775 lipid binding site [chemical binding]; lipid-binding site 226186011776 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 226186011777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186011778 Zn2+ binding site [ion binding]; other site 226186011779 Mg2+ binding site [ion binding]; other site 226186011780 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 226186011781 active site 226186011782 dimer interface [polypeptide binding]; other site 226186011783 peptide chain release factor 1; Validated; Region: prfA; PRK00591 226186011784 This domain is found in peptide chain release factors; Region: PCRF; smart00937 226186011785 RF-1 domain; Region: RF-1; pfam00472 226186011786 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 226186011787 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 226186011788 dimerization interface [polypeptide binding]; other site 226186011789 ATP binding site [chemical binding]; other site 226186011790 LemA family; Region: LemA; pfam04011 226186011791 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 226186011792 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226186011793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226186011794 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226186011795 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 226186011796 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 226186011797 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 226186011798 shikimate binding site; other site 226186011799 NAD(P) binding site [chemical binding]; other site 226186011800 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 226186011801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186011802 S-adenosylmethionine binding site [chemical binding]; other site 226186011803 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 226186011804 ATP binding site [chemical binding]; other site 226186011805 active site 226186011806 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 226186011807 substrate binding site [chemical binding]; other site 226186011808 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 226186011809 PhoH-like protein; Region: PhoH; pfam02562 226186011810 prohibitin homologues; Region: PHB; smart00244 226186011811 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 226186011812 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 226186011813 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 226186011814 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 226186011815 FIC domain binding interface [polypeptide binding]; other site 226186011816 Fic/DOC family; Region: Fic; cl00960 226186011817 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 226186011818 Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321 226186011819 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186011820 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186011821 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal; Region: Fimbrillin_C; pfam15495 226186011822 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186011823 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 226186011824 Divergent AAA domain; Region: AAA_4; pfam04326 226186011825 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186011826 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226186011827 Virulence-associated protein E; Region: VirE; pfam05272 226186011828 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186011829 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186011830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186011831 sequence-specific DNA binding site [nucleotide binding]; other site 226186011832 salt bridge; other site 226186011833 Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984 226186011834 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 226186011835 ligand binding site [chemical binding]; other site 226186011836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186011837 TPR motif; other site 226186011838 binding surface 226186011839 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186011840 Ras GTPase Activating Domain; Region: RasGAP; cl02569 226186011841 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186011842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186011843 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 226186011844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186011845 ATP binding site [chemical binding]; other site 226186011846 Mg2+ binding site [ion binding]; other site 226186011847 G-X-G motif; other site 226186011848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186011849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186011850 active site 226186011851 phosphorylation site [posttranslational modification] 226186011852 intermolecular recognition site; other site 226186011853 dimerization interface [polypeptide binding]; other site 226186011854 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 226186011855 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 226186011856 dimerization interface 3.5A [polypeptide binding]; other site 226186011857 active site 226186011858 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186011859 EamA-like transporter family; Region: EamA; cl17759 226186011860 EamA-like transporter family; Region: EamA; cl17759 226186011861 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 226186011862 Phosphotransferase enzyme family; Region: APH; pfam01636 226186011863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226186011864 active site 226186011865 substrate binding site [chemical binding]; other site 226186011866 ATP binding site [chemical binding]; other site 226186011867 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226186011868 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 226186011869 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186011870 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186011871 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186011872 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 226186011873 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226186011874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226186011875 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226186011876 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226186011877 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186011878 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186011879 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011880 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011881 Peptidase M60-like family; Region: M60-like; cl19940 226186011882 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011883 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011884 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186011885 SusD family; Region: SusD; pfam07980 226186011886 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186011887 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011888 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011889 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011890 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186011891 FecR protein; Region: FecR; pfam04773 226186011892 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186011893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186011894 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186011895 DNA binding residues [nucleotide binding] 226186011896 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226186011897 Right handed beta helix region; Region: Beta_helix; pfam13229 226186011898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186011899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 226186011900 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 226186011901 homopentamer interface [polypeptide binding]; other site 226186011902 active site 226186011903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186011904 TPR motif; other site 226186011905 recombination protein F; Reviewed; Region: recF; PRK00064 226186011906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186011907 Walker A/P-loop; other site 226186011908 ATP binding site [chemical binding]; other site 226186011909 Q-loop/lid; other site 226186011910 ABC transporter signature motif; other site 226186011911 Walker B; other site 226186011912 D-loop; other site 226186011913 H-loop/switch region; other site 226186011914 Protein of unknown function (DUF721); Region: DUF721; pfam05258 226186011915 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 226186011916 histidinol-phosphatase; Provisional; Region: PRK07328 226186011917 active site 226186011918 dimer interface [polypeptide binding]; other site 226186011919 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 226186011920 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 226186011921 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226186011922 protein binding site [polypeptide binding]; other site 226186011923 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226186011924 Catalytic dyad [active] 226186011925 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 226186011926 catalytic motif [active] 226186011927 Zn binding site [ion binding]; other site 226186011928 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 226186011929 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 226186011930 active site 226186011931 Zn binding site [ion binding]; other site 226186011932 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 226186011933 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 226186011934 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226186011935 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 226186011936 GMP synthase; Reviewed; Region: guaA; PRK00074 226186011937 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 226186011938 AMP/PPi binding site [chemical binding]; other site 226186011939 candidate oxyanion hole; other site 226186011940 catalytic triad [active] 226186011941 potential glutamine specificity residues [chemical binding]; other site 226186011942 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 226186011943 ATP Binding subdomain [chemical binding]; other site 226186011944 Ligand Binding sites [chemical binding]; other site 226186011945 Dimerization subdomain; other site 226186011946 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186011947 NHL repeat; Region: NHL; pfam01436 226186011948 NHL repeat; Region: NHL; pfam01436 226186011949 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186011950 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186011951 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186011952 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186011953 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186011954 SusD family; Region: SusD; pfam07980 226186011955 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186011956 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011957 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011958 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011959 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186011960 sugar binding site [chemical binding]; other site 226186011961 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011962 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186011963 Peptidase M60-like family; Region: M60-like; cl19940 226186011964 Erythromycin esterase; Region: Erythro_esteras; cl17110 226186011965 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 226186011966 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 226186011967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186011968 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 226186011969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 226186011970 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 226186011971 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 226186011972 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 226186011973 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 226186011974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226186011975 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226186011976 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 226186011977 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226186011978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226186011979 active site 226186011980 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226186011981 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 226186011982 JAB-like toxin 1; Region: Toxin-JAB1; pfam15659 226186011983 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 226186011984 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 226186011985 putative active site [active] 226186011986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226186011987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186011988 Walker A/P-loop; other site 226186011989 ATP binding site [chemical binding]; other site 226186011990 Q-loop/lid; other site 226186011991 ABC transporter signature motif; other site 226186011992 Walker B; other site 226186011993 D-loop; other site 226186011994 H-loop/switch region; other site 226186011995 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 226186011996 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186011997 Integrase core domain; Region: rve; pfam00665 226186011998 Integrase core domain; Region: rve_3; pfam13683 226186011999 VirE N-terminal domain; Region: VirE_N; pfam08800 226186012000 Virulence-associated protein E; Region: VirE; pfam05272 226186012001 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186012002 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186012003 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186012004 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 226186012005 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012006 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012007 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012008 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186012009 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186012010 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 226186012011 SusD family; Region: SusD; pfam07980 226186012012 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012013 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012014 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186012015 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012016 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 226186012017 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186012018 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186012019 ligand binding site [chemical binding]; other site 226186012020 flexible hinge region; other site 226186012021 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226186012022 putative switch regulator; other site 226186012023 non-specific DNA interactions [nucleotide binding]; other site 226186012024 DNA binding site [nucleotide binding] 226186012025 sequence specific DNA binding site [nucleotide binding]; other site 226186012026 putative cAMP binding site [chemical binding]; other site 226186012027 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 226186012028 Rhomboid family; Region: Rhomboid; cl11446 226186012029 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 226186012030 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 226186012031 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 226186012032 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 226186012033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226186012034 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 226186012035 putative active site [active] 226186012036 catalytic site [active] 226186012037 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 226186012038 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 226186012039 Pantoate-beta-alanine ligase; Region: PanC; cd00560 226186012040 active site 226186012041 ATP-binding site [chemical binding]; other site 226186012042 pantoate-binding site; other site 226186012043 HXXH motif; other site 226186012044 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 226186012045 tetramerization interface [polypeptide binding]; other site 226186012046 active site 226186012047 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 226186012048 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 226186012049 FAD binding pocket [chemical binding]; other site 226186012050 FAD binding motif [chemical binding]; other site 226186012051 phosphate binding motif [ion binding]; other site 226186012052 beta-alpha-beta structure motif; other site 226186012053 NAD binding pocket [chemical binding]; other site 226186012054 Iron coordination center [ion binding]; other site 226186012055 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 226186012056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226186012057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186012058 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186012059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186012060 putative substrate translocation pore; other site 226186012061 seryl-tRNA synthetase; Provisional; Region: PRK05431 226186012062 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 226186012063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 226186012064 motif 1; other site 226186012065 dimer interface [polypeptide binding]; other site 226186012066 active site 226186012067 motif 2; other site 226186012068 motif 3; other site 226186012069 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 226186012070 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 226186012071 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226186012072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186012073 motif II; other site 226186012074 TraB family; Region: TraB; pfam01963 226186012075 NlpC/P60 family; Region: NLPC_P60; pfam00877 226186012076 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226186012077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226186012078 Walker A/P-loop; other site 226186012079 ATP binding site [chemical binding]; other site 226186012080 Q-loop/lid; other site 226186012081 ABC transporter signature motif; other site 226186012082 Walker B; other site 226186012083 D-loop; other site 226186012084 H-loop/switch region; other site 226186012085 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186012086 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226186012087 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186012088 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226186012089 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226186012090 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 226186012091 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 226186012092 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226186012093 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 226186012094 MG2 domain; Region: A2M_N; cl19929 226186012095 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186012096 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 226186012097 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 226186012098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186012099 Walker A/P-loop; other site 226186012100 ATP binding site [chemical binding]; other site 226186012101 Q-loop/lid; other site 226186012102 ABC transporter signature motif; other site 226186012103 Walker B; other site 226186012104 D-loop; other site 226186012105 H-loop/switch region; other site 226186012106 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 226186012107 Bifunctional nuclease; Region: DNase-RNase; pfam02577 226186012108 UvrB/uvrC motif; Region: UVR; pfam02151 226186012109 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 226186012110 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 226186012111 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 226186012112 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 226186012113 putative RNA binding site [nucleotide binding]; other site 226186012114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186012115 S-adenosylmethionine binding site [chemical binding]; other site 226186012116 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 226186012117 catalytic site [active] 226186012118 putative active site [active] 226186012119 putative substrate binding site [chemical binding]; other site 226186012120 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 226186012121 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 226186012122 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226186012123 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 226186012124 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 226186012125 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 226186012126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226186012127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226186012128 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 226186012129 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186012130 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186012131 active site 226186012132 Fn3 associated; Region: Fn3_assoc; pfam13287 226186012133 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 226186012134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226186012135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226186012136 ligand binding site [chemical binding]; other site 226186012137 flexible hinge region; other site 226186012138 putative switch regulator; other site 226186012139 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 226186012140 non-specific DNA interactions [nucleotide binding]; other site 226186012141 DNA binding site [nucleotide binding] 226186012142 sequence specific DNA binding site [nucleotide binding]; other site 226186012143 putative cAMP binding site [chemical binding]; other site 226186012144 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 226186012145 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 226186012146 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 226186012147 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 226186012148 DinI-like family; Region: DinI; cl11630 226186012149 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226186012150 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 226186012151 putative active site [active] 226186012152 putative NTP binding site [chemical binding]; other site 226186012153 putative nucleic acid binding site [nucleotide binding]; other site 226186012154 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 226186012155 putative active site [active] 226186012156 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 226186012157 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 226186012158 Part of AAA domain; Region: AAA_19; pfam13245 226186012159 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 226186012160 AAA domain; Region: AAA_12; pfam13087 226186012161 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 226186012162 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 226186012163 RNA binding site [nucleotide binding]; other site 226186012164 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 226186012165 RNA binding site [nucleotide binding]; other site 226186012166 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 226186012167 RNA binding site [nucleotide binding]; other site 226186012168 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226186012169 RNA binding site [nucleotide binding]; other site 226186012170 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226186012171 RNA binding site [nucleotide binding]; other site 226186012172 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 226186012173 RNA binding site [nucleotide binding]; other site 226186012174 ribonuclease Z; Region: RNase_Z; TIGR02651 226186012175 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186012176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186012178 DNA binding residues [nucleotide binding] 226186012179 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 226186012180 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 226186012181 homodimer interface [polypeptide binding]; other site 226186012182 metal binding site [ion binding]; metal-binding site 226186012183 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 226186012184 homodimer interface [polypeptide binding]; other site 226186012185 active site 226186012186 putative chemical substrate binding site [chemical binding]; other site 226186012187 metal binding site [ion binding]; metal-binding site 226186012188 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 226186012189 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 226186012190 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 226186012191 active site 226186012192 HIGH motif; other site 226186012193 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226186012194 KMSKS motif; other site 226186012195 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 226186012196 tRNA binding surface [nucleotide binding]; other site 226186012197 anticodon binding site; other site 226186012198 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 226186012199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186012200 dimer interface [polypeptide binding]; other site 226186012201 phosphorylation site [posttranslational modification] 226186012202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186012203 ATP binding site [chemical binding]; other site 226186012204 Mg2+ binding site [ion binding]; other site 226186012205 G-X-G motif; other site 226186012206 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186012207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186012209 DNA binding residues [nucleotide binding] 226186012210 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186012211 FecR protein; Region: FecR; pfam04773 226186012212 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186012213 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012214 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012215 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186012216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012217 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186012218 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012219 SusD family; Region: SusD; pfam07980 226186012220 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 226186012221 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 226186012222 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 226186012223 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 226186012224 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 226186012225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186012226 nucleotide binding region [chemical binding]; other site 226186012227 ATP-binding site [chemical binding]; other site 226186012228 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 226186012229 SEC-C motif; Region: SEC-C; pfam02810 226186012230 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 226186012231 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 226186012232 pantothenate kinase; Reviewed; Region: PRK13320 226186012233 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 226186012234 Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200 226186012235 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226186012236 Domain of unknown function DUF21; Region: DUF21; pfam01595 226186012237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226186012238 Transporter associated domain; Region: CorC_HlyC; smart01091 226186012239 SurA N-terminal domain; Region: SurA_N_2; pfam13623 226186012240 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 226186012241 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 226186012242 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 226186012243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186012244 FeS/SAM binding site; other site 226186012245 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 226186012246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186012247 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226186012248 Walker A motif; other site 226186012249 ATP binding site [chemical binding]; other site 226186012250 Walker B motif; other site 226186012251 arginine finger; other site 226186012252 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226186012253 Lipopolysaccharide-assembly; Region: LptE; pfam04390 226186012254 protein translocase, SecG subunit; Region: secG; TIGR00810 226186012255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186012256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226186012257 putative substrate translocation pore; other site 226186012258 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 226186012259 putative carbohydrate kinase; Provisional; Region: PRK10565 226186012260 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 226186012261 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 226186012262 putative substrate binding site [chemical binding]; other site 226186012263 putative ATP binding site [chemical binding]; other site 226186012264 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 226186012265 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226186012266 POT family; Region: PTR2; cl17359 226186012267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186012268 putative substrate translocation pore; other site 226186012269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186012270 active site 226186012271 adenylate kinase; Reviewed; Region: adk; PRK00279 226186012272 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 226186012273 AMP-binding site [chemical binding]; other site 226186012274 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 226186012275 GTPase CgtA; Reviewed; Region: obgE; PRK12298 226186012276 GTP1/OBG; Region: GTP1_OBG; pfam01018 226186012277 Obg GTPase; Region: Obg; cd01898 226186012278 G1 box; other site 226186012279 GTP/Mg2+ binding site [chemical binding]; other site 226186012280 Switch I region; other site 226186012281 G2 box; other site 226186012282 G3 box; other site 226186012283 Switch II region; other site 226186012284 G4 box; other site 226186012285 G5 box; other site 226186012286 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 226186012287 B3/4 domain; Region: B3_4; cl19243 226186012288 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226186012289 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186012290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186012291 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186012292 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186012293 active site 226186012294 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186012295 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 226186012296 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 226186012297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186012298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186012299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186012300 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 226186012301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186012302 putative substrate translocation pore; other site 226186012303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012304 TPR motif; other site 226186012305 binding surface 226186012306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012307 binding surface 226186012308 TPR motif; other site 226186012309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186012310 TPR repeat; Region: TPR_11; pfam13414 226186012311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012312 binding surface 226186012313 TPR motif; other site 226186012314 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186012315 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 226186012316 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186012317 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012318 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186012319 DNA binding residues [nucleotide binding] 226186012320 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186012321 FecR protein; Region: FecR; pfam04773 226186012322 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186012323 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012324 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012326 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186012327 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012328 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 226186012329 active site 226186012330 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186012331 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186012332 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 226186012333 DNA polymerase IV; Validated; Region: PRK02406 226186012334 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 226186012335 active site 226186012336 DNA binding site [nucleotide binding] 226186012337 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226186012338 Domain of unknown function (DUF4627); Region: DUF4627; pfam15425 226186012339 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226186012340 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 226186012341 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186012342 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226186012343 Poxvirus L3/FP4 protein; Region: Pox_L3_FP4; pfam03339 226186012344 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 226186012345 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 226186012346 phosphodiesterase; Provisional; Region: PRK12704 226186012347 KH domain; Region: KH_1; pfam00013 226186012348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226186012349 Zn2+ binding site [ion binding]; other site 226186012350 Mg2+ binding site [ion binding]; other site 226186012351 Cell division protein ZapA; Region: ZapA; pfam05164 226186012352 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 226186012353 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 226186012354 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 226186012355 N- and C-terminal domain interface [polypeptide binding]; other site 226186012356 D-xylulose kinase; Region: XylB; TIGR01312 226186012357 active site 226186012358 MgATP binding site [chemical binding]; other site 226186012359 catalytic site [active] 226186012360 metal binding site [ion binding]; metal-binding site 226186012361 xylulose binding site [chemical binding]; other site 226186012362 putative homodimer interface [polypeptide binding]; other site 226186012363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 226186012364 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 226186012365 NAD(P) binding site [chemical binding]; other site 226186012366 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 226186012367 intersubunit interface [polypeptide binding]; other site 226186012368 active site 226186012369 catalytic residue [active] 226186012370 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 226186012371 Uncharacterized conserved protein [Function unknown]; Region: COG3391 226186012372 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226186012373 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 226186012374 Cytochrome c; Region: Cytochrom_C; pfam00034 226186012375 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 226186012376 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 226186012377 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226186012378 homotrimer interaction site [polypeptide binding]; other site 226186012379 putative active site [active] 226186012380 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 226186012381 homotrimer interaction site [polypeptide binding]; other site 226186012382 putative active site [active] 226186012383 ResB-like family; Region: ResB; cl09125 226186012384 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226186012385 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 226186012386 DNA binding site [nucleotide binding] 226186012387 dimer interface [polypeptide binding]; other site 226186012388 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 226186012389 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 226186012390 Transposase, Mutator family; Region: Transposase_mut; cl19537 226186012391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 226186012392 gp58-like protein; Region: Gp58; pfam07902 226186012393 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226186012394 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186012395 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186012396 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 226186012397 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226186012398 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226186012399 active site 226186012400 metal binding site [ion binding]; metal-binding site 226186012401 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186012402 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186012403 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226186012404 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226186012405 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 226186012406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186012407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186012408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226186012409 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226186012410 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226186012411 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 226186012412 Protein of unknown function (DUF454); Region: DUF454; pfam04304 226186012413 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 226186012414 active site 226186012415 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 226186012416 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 226186012417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186012418 FeS/SAM binding site; other site 226186012419 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 226186012420 Cysteine-rich domain; Region: CCG; pfam02754 226186012421 Cysteine-rich domain; Region: CCG; pfam02754 226186012422 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 226186012423 HD domain; Region: HD_3; cl17350 226186012424 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 226186012425 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226186012426 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 226186012427 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 226186012428 dimer interface [polypeptide binding]; other site 226186012429 pyridoxal binding site [chemical binding]; other site 226186012430 ATP binding site [chemical binding]; other site 226186012431 Predicted membrane protein [Function unknown]; Region: COG2311 226186012432 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226186012433 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012434 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048 226186012435 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186012436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012437 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186012438 DNA binding residues [nucleotide binding] 226186012439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226186012440 putative acyl-acceptor binding pocket; other site 226186012441 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 226186012442 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 226186012443 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012444 von Willebrand factor; Region: vWF_A; pfam12450 226186012445 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 226186012446 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 226186012447 metal ion-dependent adhesion site (MIDAS); other site 226186012448 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 226186012449 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 226186012450 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 226186012451 putative ArsC-like catalytic residues; other site 226186012452 putative TRX-like catalytic residues [active] 226186012453 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 226186012454 putative active site [active] 226186012455 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012456 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012457 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012458 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186012459 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012460 Sulfate transporter family; Region: Sulfate_transp; cl19250 226186012461 xanthine permease; Region: pbuX; TIGR03173 226186012462 KamA family protein; Region: TIGR00238; cl15377 226186012463 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226186012464 Divergent AAA domain; Region: AAA_4; pfam04326 226186012465 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186012466 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186012467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226186012468 active site 226186012469 DNA binding site [nucleotide binding] 226186012470 Int/Topo IB signature motif; other site 226186012471 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226186012472 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 226186012473 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 226186012474 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226186012475 ligand binding site [chemical binding]; other site 226186012476 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 226186012477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186012478 FeS/SAM binding site; other site 226186012479 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226186012480 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 226186012481 MgtC family; Region: MgtC; pfam02308 226186012482 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 226186012483 Ion transport protein; Region: Ion_trans; pfam00520 226186012484 Ion channel; Region: Ion_trans_2; pfam07885 226186012485 Double zinc ribbon; Region: DZR; pfam12773 226186012486 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 226186012487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226186012488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226186012489 catalytic residue [active] 226186012490 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 226186012491 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_3; cd08975 226186012492 putative DNA binding site [nucleotide binding]; other site 226186012493 catalytic residue [active] 226186012494 putative H2TH interface [polypeptide binding]; other site 226186012495 putative catalytic residues [active] 226186012496 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 226186012497 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226186012498 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186012499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012500 binding surface 226186012501 TPR motif; other site 226186012502 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 226186012503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186012504 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 226186012505 NAD(P) binding site [chemical binding]; other site 226186012506 active site 226186012507 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 226186012508 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 226186012509 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 226186012510 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 226186012511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186012512 NAD(P) binding site [chemical binding]; other site 226186012513 active site 226186012514 hypothetical protein; Provisional; Region: PRK10410 226186012515 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 226186012516 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226186012517 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186012518 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 226186012519 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226186012520 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226186012521 active site 226186012522 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 226186012523 active site 226186012524 catalytic triad [active] 226186012525 oxyanion hole [active] 226186012526 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 226186012527 putative active site [active] 226186012528 putative catalytic site [active] 226186012529 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 226186012530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 226186012531 putative metal binding site [ion binding]; other site 226186012532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226186012533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226186012534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186012535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186012536 Coenzyme A binding pocket [chemical binding]; other site 226186012537 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 226186012538 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 226186012539 SEC-C motif; Region: SEC-C; cl19389 226186012540 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226186012541 active site 226186012542 NTP binding site [chemical binding]; other site 226186012543 metal binding triad [ion binding]; metal-binding site 226186012544 antibiotic binding site [chemical binding]; other site 226186012545 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 226186012546 VirE N-terminal domain; Region: VirE_N; pfam08800 226186012547 Virulence-associated protein E; Region: VirE; pfam05272 226186012548 Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990 226186012549 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 226186012550 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226186012551 catalytic Zn binding site [ion binding]; other site 226186012552 NAD(P) binding site [chemical binding]; other site 226186012553 structural Zn binding site [ion binding]; other site 226186012554 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226186012555 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226186012556 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186012557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186012558 non-specific DNA binding site [nucleotide binding]; other site 226186012559 salt bridge; other site 226186012560 sequence-specific DNA binding site [nucleotide binding]; other site 226186012561 Protein of unknown function DUF262; Region: DUF262; pfam03235 226186012562 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 226186012563 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 226186012564 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 226186012565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186012566 ATP binding site [chemical binding]; other site 226186012567 putative Mg++ binding site [ion binding]; other site 226186012568 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 226186012569 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 226186012570 HsdM N-terminal domain; Region: HsdM_N; pfam12161 226186012571 Methyltransferase domain; Region: Methyltransf_26; pfam13659 226186012572 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 226186012573 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012574 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226186012575 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012576 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 226186012577 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 226186012578 Int/Topo IB signature motif; other site 226186012579 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012580 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012581 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226186012582 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012583 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186012584 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 226186012585 putative active site [active] 226186012586 putative metal binding site [ion binding]; other site 226186012587 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 226186012588 putative active site [active] 226186012589 putative metal binding site [ion binding]; other site 226186012590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186012591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186012592 non-specific DNA binding site [nucleotide binding]; other site 226186012593 salt bridge; other site 226186012594 sequence-specific DNA binding site [nucleotide binding]; other site 226186012595 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 226186012596 Divergent AAA domain; Region: AAA_4; pfam04326 226186012597 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186012598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226186012599 putative DNA binding site [nucleotide binding]; other site 226186012600 putative Zn2+ binding site [ion binding]; other site 226186012601 Restriction endonuclease; Region: Mrr_cat; cl19295 226186012602 Syntaxin; Region: Syntaxin; cl00143 226186012603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226186012604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186012605 salt bridge; other site 226186012606 non-specific DNA binding site [nucleotide binding]; other site 226186012607 sequence-specific DNA binding site [nucleotide binding]; other site 226186012608 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 226186012609 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 226186012610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186012611 ATP binding site [chemical binding]; other site 226186012612 putative Mg++ binding site [ion binding]; other site 226186012613 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 226186012614 Protein of unknown function DUF91; Region: DUF91; cl00709 226186012615 Uncharacterized conserved protein [Function unknown]; Region: COG3586 226186012616 Protein of unknown function DUF262; Region: DUF262; pfam03235 226186012617 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 226186012618 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 226186012619 HsdM N-terminal domain; Region: HsdM_N; pfam12161 226186012620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186012621 S-adenosylmethionine binding site [chemical binding]; other site 226186012622 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226186012623 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 226186012624 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012625 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226186012626 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012627 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226186012628 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012629 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012630 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226186012631 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226186012632 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226186012633 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 226186012634 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226186012635 Int/Topo IB signature motif; other site 226186012636 AAA domain; Region: AAA_25; pfam13481 226186012637 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186012638 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186012639 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186012640 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 226186012641 Int/Topo IB signature motif; other site 226186012642 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186012643 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 226186012644 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 226186012645 trmE is a tRNA modification GTPase; Region: trmE; cd04164 226186012646 G1 box; other site 226186012647 GTP/Mg2+ binding site [chemical binding]; other site 226186012648 Switch I region; other site 226186012649 G2 box; other site 226186012650 Switch II region; other site 226186012651 G3 box; other site 226186012652 G4 box; other site 226186012653 G5 box; other site 226186012654 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 226186012655 PAS fold; Region: PAS_3; pfam08447 226186012656 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226186012657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186012658 dimer interface [polypeptide binding]; other site 226186012659 phosphorylation site [posttranslational modification] 226186012660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186012661 ATP binding site [chemical binding]; other site 226186012662 Mg2+ binding site [ion binding]; other site 226186012663 G-X-G motif; other site 226186012664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186012665 active site 226186012666 phosphorylation site [posttranslational modification] 226186012667 intermolecular recognition site; other site 226186012668 dimerization interface [polypeptide binding]; other site 226186012669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226186012670 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 226186012671 NAD binding site [chemical binding]; other site 226186012672 substrate binding site [chemical binding]; other site 226186012673 putative active site [active] 226186012674 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 226186012675 hypothetical protein; Provisional; Region: PRK13665 226186012676 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 226186012677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012678 binding surface 226186012679 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226186012680 TPR motif; other site 226186012681 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 226186012682 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 226186012683 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 226186012684 Ligand Binding Site [chemical binding]; other site 226186012685 TIGR00269 family protein; Region: TIGR00269 226186012686 Protein of unknown function, DUF486; Region: DUF486; cl01236 226186012687 ApbE family; Region: ApbE; pfam02424 226186012688 Predicted membrane protein [Function unknown]; Region: COG1971 226186012689 Domain of unknown function DUF; Region: DUF204; pfam02659 226186012690 Domain of unknown function DUF; Region: DUF204; pfam02659 226186012691 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 226186012692 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 226186012693 Ligand binding site; other site 226186012694 Putative Catalytic site; other site 226186012695 DXD motif; other site 226186012696 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 226186012697 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226186012698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186012699 active site 226186012700 phosphorylation site [posttranslational modification] 226186012701 intermolecular recognition site; other site 226186012702 dimerization interface [polypeptide binding]; other site 226186012703 LytTr DNA-binding domain; Region: LytTR; pfam04397 226186012704 Histidine kinase; Region: His_kinase; pfam06580 226186012705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 226186012706 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 226186012707 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 226186012708 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186012709 Outer membrane protein beta-barrel family; Region: OMP_b-brl_3; pfam14905 226186012710 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 226186012711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186012713 DNA binding residues [nucleotide binding] 226186012714 enolase; Provisional; Region: eno; PRK00077 226186012715 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 226186012716 dimer interface [polypeptide binding]; other site 226186012717 metal binding site [ion binding]; metal-binding site 226186012718 substrate binding pocket [chemical binding]; other site 226186012719 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226186012720 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226186012721 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 226186012722 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 226186012723 Peptidase family M23; Region: Peptidase_M23; pfam01551 226186012724 putative transposase OrfB; Reviewed; Region: PHA02517 226186012725 Integrase core domain; Region: rve; pfam00665 226186012726 Integrase core domain; Region: rve_3; pfam13683 226186012727 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 226186012728 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 226186012729 Transposase [DNA replication, recombination, and repair]; Region: COG5433 226186012730 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 226186012731 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 226186012732 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 226186012733 amidophosphoribosyltransferase; Region: purF; TIGR01134 226186012734 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 226186012735 active site 226186012736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226186012737 active site 226186012738 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 226186012739 peptidase T-like protein; Region: PepT-like; TIGR01883 226186012740 metal binding site [ion binding]; metal-binding site 226186012741 dimer interface [polypeptide binding]; other site 226186012742 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 226186012743 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 226186012744 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 226186012745 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226186012746 TrkA-C domain; Region: TrkA_C; pfam02080 226186012747 TrkA-C domain; Region: TrkA_C; pfam02080 226186012748 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 226186012749 nucleotide binding site/active site [active] 226186012750 HIT family signature motif; other site 226186012751 catalytic residue [active] 226186012752 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226186012753 RNA binding surface [nucleotide binding]; other site 226186012754 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 226186012755 putative active site [active] 226186012756 catalytic residue [active] 226186012757 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 226186012758 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 226186012759 5S rRNA interface [nucleotide binding]; other site 226186012760 CTC domain interface [polypeptide binding]; other site 226186012761 L16 interface [polypeptide binding]; other site 226186012762 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 226186012763 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 226186012764 transcription antitermination factor NusB; Region: nusB; TIGR01951 226186012765 Preprotein translocase subunit; Region: YajC; pfam02699 226186012766 YbbR-like protein; Region: YbbR; pfam07949 226186012767 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 226186012768 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 226186012769 CoA-binding site [chemical binding]; other site 226186012770 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226186012771 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 226186012772 Clp amino terminal domain; Region: Clp_N; pfam02861 226186012773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186012774 Walker A motif; other site 226186012775 ATP binding site [chemical binding]; other site 226186012776 Walker B motif; other site 226186012777 arginine finger; other site 226186012778 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 226186012779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226186012780 Walker A motif; other site 226186012781 ATP binding site [chemical binding]; other site 226186012782 Walker B motif; other site 226186012783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226186012784 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 226186012785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226186012786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226186012787 dimerization interface [polypeptide binding]; other site 226186012788 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 226186012789 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 226186012790 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186012791 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 226186012792 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 226186012793 nucleotide binding site [chemical binding]; other site 226186012794 putative NEF/HSP70 interaction site [polypeptide binding]; other site 226186012795 SBD interface [polypeptide binding]; other site 226186012796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226186012797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226186012798 binding surface 226186012799 TPR motif; other site 226186012800 AAA domain; Region: AAA_22; pfam13401 226186012801 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 226186012802 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012803 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012804 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012805 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012806 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 226186012807 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 226186012808 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 226186012809 hypothetical protein; Provisional; Region: PRK11770 226186012810 Domain of unknown function (DUF307); Region: DUF307; pfam03733 226186012811 Domain of unknown function (DUF307); Region: DUF307; pfam03733 226186012812 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 226186012813 recombinase A; Provisional; Region: recA; PRK09354 226186012814 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 226186012815 hexamer interface [polypeptide binding]; other site 226186012816 Walker A motif; other site 226186012817 ATP binding site [chemical binding]; other site 226186012818 Walker B motif; other site 226186012819 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 226186012820 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 226186012821 catalytic triad [active] 226186012822 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 226186012823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226186012824 META domain; Region: META; pfam03724 226186012825 META domain; Region: META; pfam03724 226186012826 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 226186012827 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 226186012828 nucleotide binding site [chemical binding]; other site 226186012829 NEF interaction site [polypeptide binding]; other site 226186012830 SBD interface [polypeptide binding]; other site 226186012831 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 226186012832 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186012833 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226186012834 DNA binding residues [nucleotide binding] 226186012835 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186012836 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186012837 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 226186012838 Int/Topo IB signature motif; other site 226186012839 Helix-turn-helix domain; Region: HTH_17; pfam12728 226186012840 VirE N-terminal domain; Region: VirE_N; pfam08800 226186012841 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 226186012842 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 226186012843 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186012844 multiple promoter invertase; Provisional; Region: mpi; PRK13413 226186012845 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226186012846 catalytic residues [active] 226186012847 catalytic nucleophile [active] 226186012848 Presynaptic Site I dimer interface [polypeptide binding]; other site 226186012849 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226186012850 Synaptic Flat tetramer interface [polypeptide binding]; other site 226186012851 Synaptic Site I dimer interface [polypeptide binding]; other site 226186012852 DNA binding site [nucleotide binding] 226186012853 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 226186012854 DNA-binding interface [nucleotide binding]; DNA binding site 226186012855 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226186012856 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 226186012857 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 226186012858 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 226186012859 PLD-like domain; Region: PLDc_2; pfam13091 226186012860 putative homodimer interface [polypeptide binding]; other site 226186012861 putative active site [active] 226186012862 catalytic site [active] 226186012863 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186012864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226186012865 ATP binding site [chemical binding]; other site 226186012866 putative Mg++ binding site [ion binding]; other site 226186012867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226186012868 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226186012869 nucleotide binding region [chemical binding]; other site 226186012870 ATP-binding site [chemical binding]; other site 226186012871 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 226186012872 Divergent AAA domain; Region: AAA_4; pfam04326 226186012873 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 226186012874 HTH domain; Region: HTH_11; pfam08279 226186012875 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186012876 Sulfatase; Region: Sulfatase; pfam00884 226186012877 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186012878 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186012879 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186012880 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012881 SusD family; Region: SusD; pfam07980 226186012882 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186012883 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012884 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012885 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012886 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 226186012887 FecR protein; Region: FecR; pfam04773 226186012888 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186012889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186012890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186012892 DNA binding residues [nucleotide binding] 226186012893 Phosphate transporter family; Region: PHO4; pfam01384 226186012894 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 226186012895 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 226186012896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226186012897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186012898 Coenzyme A binding pocket [chemical binding]; other site 226186012899 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012900 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186012901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012902 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186012903 DNA binding residues [nucleotide binding] 226186012904 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186012905 FecR protein; Region: FecR; pfam04773 226186012906 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186012907 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012908 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 226186012909 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 226186012910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186012911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186012912 DNA binding residues [nucleotide binding] 226186012913 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 226186012914 Cl- selectivity filter; other site 226186012915 Cl- binding residues [ion binding]; other site 226186012916 pore gating glutamate residue; other site 226186012917 dimer interface [polypeptide binding]; other site 226186012918 H+/Cl- coupling transport residue; other site 226186012919 TrkA-C domain; Region: TrkA_C; pfam02080 226186012920 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 226186012921 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 226186012922 AP (apurinic/apyrimidinic) site pocket; other site 226186012923 DNA interaction; other site 226186012924 Metal-binding active site; metal-binding site 226186012925 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226186012926 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226186012927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186012928 putative substrate translocation pore; other site 226186012929 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226186012930 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226186012931 nucleotide binding site [chemical binding]; other site 226186012932 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 226186012933 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186012934 Sulfatase; Region: Sulfatase; pfam00884 226186012935 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226186012936 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 226186012937 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012938 SusD family; Region: SusD; pfam07980 226186012939 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012940 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012941 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 226186012942 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 226186012943 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 226186012944 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186012945 Two component regulator propeller; Region: Reg_prop; pfam07494 226186012946 Two component regulator propeller; Region: Reg_prop; pfam07494 226186012947 Two component regulator propeller; Region: Reg_prop; pfam07494 226186012948 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186012949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186012950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186012951 dimer interface [polypeptide binding]; other site 226186012952 phosphorylation site [posttranslational modification] 226186012953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186012954 ATP binding site [chemical binding]; other site 226186012955 Mg2+ binding site [ion binding]; other site 226186012956 G-X-G motif; other site 226186012957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226186012958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226186012959 active site 226186012960 phosphorylation site [posttranslational modification] 226186012961 intermolecular recognition site; other site 226186012962 dimerization interface [polypeptide binding]; other site 226186012963 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186012964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186012965 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 226186012966 cysteine synthase; Region: PLN02565 226186012967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226186012968 catalytic residue [active] 226186012969 Cation transport protein; Region: TrkH; cl17365 226186012970 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226186012971 Cation transport protein; Region: TrkH; cl17365 226186012972 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226186012973 TrkA-N domain; Region: TrkA_N; pfam02254 226186012974 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186012975 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186012976 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186012977 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186012978 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 226186012979 SusE outer membrane protein; Region: SusE; pfam14292 226186012980 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 226186012981 starch binding site [chemical binding]; other site 226186012982 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186012983 SusD family; Region: SusD; pfam07980 226186012984 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186012985 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186012986 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186012987 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 226186012988 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 226186012989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 226186012990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226186012991 dimer interface [polypeptide binding]; other site 226186012992 phosphorylation site [posttranslational modification] 226186012993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186012994 ATP binding site [chemical binding]; other site 226186012995 Mg2+ binding site [ion binding]; other site 226186012996 G-X-G motif; other site 226186012997 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226186012998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226186012999 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 226186013000 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186013001 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186013002 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186013003 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186013004 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 226186013005 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 226186013006 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 226186013007 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226186013008 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 226186013009 oligomer interface [polypeptide binding]; other site 226186013010 metal binding site [ion binding]; metal-binding site 226186013011 metal binding site [ion binding]; metal-binding site 226186013012 Cl binding site [ion binding]; other site 226186013013 aspartate ring; other site 226186013014 basic sphincter; other site 226186013015 putative hydrophobic gate; other site 226186013016 periplasmic entrance; other site 226186013017 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 226186013018 MutS domain III; Region: MutS_III; pfam05192 226186013019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226186013020 Walker A/P-loop; other site 226186013021 ATP binding site [chemical binding]; other site 226186013022 Q-loop/lid; other site 226186013023 ABC transporter signature motif; other site 226186013024 Walker B; other site 226186013025 D-loop; other site 226186013026 H-loop/switch region; other site 226186013027 E2 domain of amyloid precursor protein; Region: APP_E2; pfam12925 226186013028 Smr domain; Region: Smr; pfam01713 226186013029 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 226186013030 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 226186013031 active site 226186013032 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 226186013033 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 226186013034 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 226186013035 Sulfatase; Region: Sulfatase; pfam00884 226186013036 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 226186013037 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 226186013038 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 226186013039 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 226186013040 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186013041 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226186013042 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226186013043 pullulanase, type I; Region: pulA_typeI; TIGR02104 226186013044 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 226186013045 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 226186013046 Ca binding site [ion binding]; other site 226186013047 active site 226186013048 catalytic site [active] 226186013049 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 226186013050 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 226186013051 active site 226186013052 Na/Ca binding site [ion binding]; other site 226186013053 catalytic site [active] 226186013054 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 226186013055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226186013056 S-adenosylmethionine binding site [chemical binding]; other site 226186013057 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 226186013058 Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321 226186013059 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 226186013060 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226186013061 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 226186013062 HlyD family secretion protein; Region: HlyD_3; pfam13437 226186013063 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 226186013064 MMPL family; Region: MMPL; cl14618 226186013065 Outer membrane efflux protein; Region: OEP; pfam02321 226186013066 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 226186013067 Outer membrane efflux protein; Region: OEP; pfam02321 226186013068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226186013069 Coenzyme A binding pocket [chemical binding]; other site 226186013070 YoaP-like; Region: YoaP; pfam14268 226186013071 Helix-turn-helix domain; Region: HTH_18; pfam12833 226186013072 Protein of unknown function, DUF488; Region: DUF488; cl01246 226186013073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226186013074 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226186013075 active site 226186013076 motif I; other site 226186013077 motif II; other site 226186013078 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226186013079 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 226186013080 CoenzymeA binding site [chemical binding]; other site 226186013081 subunit interaction site [polypeptide binding]; other site 226186013082 PHB binding site; other site 226186013083 isochorismate synthases; Region: isochor_syn; TIGR00543 226186013084 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 226186013085 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 226186013086 dimer interface [polypeptide binding]; other site 226186013087 tetramer interface [polypeptide binding]; other site 226186013088 PYR/PP interface [polypeptide binding]; other site 226186013089 TPP binding site [chemical binding]; other site 226186013090 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 226186013091 TPP-binding site; other site 226186013092 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 226186013093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226186013094 substrate binding site [chemical binding]; other site 226186013095 oxyanion hole (OAH) forming residues; other site 226186013096 trimer interface [polypeptide binding]; other site 226186013097 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 226186013098 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 226186013099 active site 226186013100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226186013101 acyl-activating enzyme (AAE) consensus motif; other site 226186013102 AMP binding site [chemical binding]; other site 226186013103 active site 226186013104 CoA binding site [chemical binding]; other site 226186013105 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186013106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186013107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186013108 DNA binding residues [nucleotide binding] 226186013109 FecR protein; Region: FecR; pfam04773 226186013110 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186013111 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186013112 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186013113 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186013114 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 226186013115 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186013116 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 226186013117 active site 226186013118 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186013119 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 226186013120 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 226186013121 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186013122 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 226186013123 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 226186013124 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 226186013125 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186013126 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226186013127 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 226186013128 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 226186013129 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 226186013130 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 226186013131 Ferritin-like domain; Region: Ferritin; pfam00210 226186013132 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226186013133 dimerization interface [polypeptide binding]; other site 226186013134 DPS ferroxidase diiron center [ion binding]; other site 226186013135 ion pore; other site 226186013136 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 226186013137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226186013138 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 226186013139 dimerization interface [polypeptide binding]; other site 226186013140 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226186013141 EamA-like transporter family; Region: EamA; pfam00892 226186013142 EamA-like transporter family; Region: EamA; pfam00892 226186013143 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 226186013144 amphipathic channel; other site 226186013145 Asn-Pro-Ala signature motifs; other site 226186013146 NigD-like protein; Region: NigD; pfam12667 226186013147 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226186013148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186013149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226186013150 DNA binding residues [nucleotide binding] 226186013151 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 226186013152 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 226186013153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226186013154 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226186013155 DNA binding residues [nucleotide binding] 226186013156 FecR protein; Region: FecR; pfam04773 226186013157 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 226186013158 Secretin and TonB N terminus short domain; Region: STN; pfam07660 226186013159 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 226186013160 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 226186013161 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 226186013162 starch binding outer membrane protein SusD; Region: SusD; cd08977 226186013163 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226186013164 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 226186013165 Trp docking motif [polypeptide binding]; other site 226186013166 active site 226186013167 PQQ-like domain; Region: PQQ_2; pfam13360 226186013168 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 226186013169 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186013170 putative active site [active] 226186013171 catalytic site [active] 226186013172 putative metal binding site [ion binding]; other site 226186013173 oligomer interface [polypeptide binding]; other site 226186013174 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226186013175 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 226186013176 putative active site [active] 226186013177 catalytic site [active] 226186013178 putative metal binding site [ion binding]; other site 226186013179 oligomer interface [polypeptide binding]; other site 226186013180 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 226186013181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226186013182 putative substrate translocation pore; other site 226186013183 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 226186013184 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 226186013185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186013186 non-specific DNA binding site [nucleotide binding]; other site 226186013187 salt bridge; other site 226186013188 sequence-specific DNA binding site [nucleotide binding]; other site 226186013189 VirE N-terminal domain; Region: VirE_N; pfam08800 226186013190 Virulence-associated protein E; Region: VirE; pfam05272 226186013191 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 226186013192 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226186013193 amidase catalytic site [active] 226186013194 Zn binding residues [ion binding]; other site 226186013195 substrate binding site [chemical binding]; other site 226186013196 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 226186013197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226186013198 FeS/SAM binding site; other site 226186013199 Pyruvate formate lyase 1; Region: PFL1; cd01678 226186013200 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 226186013201 coenzyme A binding site [chemical binding]; other site 226186013202 active site 226186013203 catalytic residues [active] 226186013204 glycine loop; other site 226186013205 Phage integrase SAM-like domain; Region: Phage_int_SAM_5; pfam13102 226186013206 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 226186013207 Int/Topo IB signature motif; other site 226186013208 Transposase; Region: DEDD_Tnp_IS110; pfam01548 226186013209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 226186013210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 226186013211 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 226186013212 Methyltransferase domain; Region: Methyltransf_26; pfam13659 226186013213 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226186013214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226186013215 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 226186013216 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 226186013217 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 226186013218 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 226186013219 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 226186013220 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 226186013221 cofactor binding site; other site 226186013222 DNA binding site [nucleotide binding] 226186013223 substrate interaction site [chemical binding]; other site 226186013224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 226186013225 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226186013226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226186013227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226186013228 ATP binding site [chemical binding]; other site 226186013229 Mg2+ binding site [ion binding]; other site 226186013230 G-X-G motif; other site 226186013231 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 226186013232 AAA-like domain; Region: AAA_10; pfam12846 226186013233 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226186013234 ATP binding site [chemical binding]; other site 226186013235 Walker A motif; other site 226186013236 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 226186013237 Walker B motif; other site 226186013238 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 226186013239 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 226186013240 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 226186013241 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226186013242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226186013243 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 226186013244 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 226186013245 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 226186013246 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 226186013247 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186013248 AAA domain; Region: AAA_22; pfam13401 226186013249 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 226186013250 choline-phosphate cytidylyltransferase; Region: PLN02413 226186013251 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 226186013252 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 226186013253 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 226186013254 Protein of unknown function (DUF3989); Region: DUF3989; pfam13150 226186013255 Protein of unknown function (DUF3714); Region: DUF3714; cl19909 226186013256 Protein of unknown function (DUF3714); Region: DUF3714; cl19909 226186013257 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 226186013258 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 226186013259 SprT-like family; Region: SprT-like; pfam10263 226186013260 Initiator Replication protein; Region: Rep_3; pfam01051 226186013261 chromosome segregation protein; Provisional; Region: PRK02224 226186013262 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 226186013263 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 226186013264 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226186013265 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 226186013266 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 226186013267 Domain of unknown function DUF87; Region: DUF87; cl19135 226186013268 Protein of unknown function (DUF3714); Region: DUF3714; cl19909 226186013269 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 226186013270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226186013271 non-specific DNA binding site [nucleotide binding]; other site 226186013272 salt bridge; other site 226186013273 sequence-specific DNA binding site [nucleotide binding]; other site 226186013274 Uncharacterized protein conserved in Bacteroidetes; Region: DUF4425; cd11379 226186013275 dimer interface [polypeptide binding]; other site 226186013276 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 226186013277 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 226186013278 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 226186013279 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 226186013280 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 226186013281 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 226186013282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226186013283 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226186013284 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226186013285 P-loop; other site 226186013286 Magnesium ion binding site [ion binding]; other site 226186013287 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 226186013288 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226186013289 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 226186013290 catalytic residues [active] 226186013291 catalytic nucleophile [active] 226186013292 Presynaptic Site I dimer interface [polypeptide binding]; other site 226186013293 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 226186013294 Synaptic Flat tetramer interface [polypeptide binding]; other site 226186013295 Synaptic Site I dimer interface [polypeptide binding]; other site 226186013296 DNA binding site [nucleotide binding] 226186013297 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 226186013298 Fic/DOC family; Region: Fic; pfam02661 226186013299 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 226186013300 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227