-- dump date   	20140619_000708
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
435590000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
435590000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
435590000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590000004	Walker A motif; other site
435590000005	ATP binding site [chemical binding]; other site
435590000006	Walker B motif; other site
435590000007	arginine finger; other site
435590000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
435590000009	DnaA box-binding interface [nucleotide binding]; other site
435590000010	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
435590000011	dimer interface [polypeptide binding]; other site
435590000012	FMN binding site [chemical binding]; other site
435590000013	NADPH bind site [chemical binding]; other site
435590000014	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
435590000015	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
435590000016	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
435590000017	active site
435590000018	dimer interface [polypeptide binding]; other site
435590000019	effector binding site; other site
435590000020	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
435590000021	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
435590000022	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
435590000023	homooctamer interface [polypeptide binding]; other site
435590000024	active site
435590000025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000026	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590000027	FeS/SAM binding site; other site
435590000028	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590000029	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590000030	Probable Catalytic site; other site
435590000031	metal-binding site
435590000032	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
435590000033	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590000034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000035	FeS/SAM binding site; other site
435590000036	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590000037	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590000038	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
435590000039	putative AMP binding site [chemical binding]; other site
435590000040	putative active site [active]
435590000041	acyl-activating enzyme (AAE) consensus motif; other site
435590000042	putative CoA binding site [chemical binding]; other site
435590000043	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
435590000044	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
435590000045	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
435590000046	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
435590000047	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
435590000048	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
435590000049	MarR family; Region: MarR_2; pfam12802
435590000050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590000051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000052	active site
435590000053	phosphorylation site [posttranslational modification]
435590000054	intermolecular recognition site; other site
435590000055	dimerization interface [polypeptide binding]; other site
435590000056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590000057	DNA binding site [nucleotide binding]
435590000058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000060	dimer interface [polypeptide binding]; other site
435590000061	phosphorylation site [posttranslational modification]
435590000062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000063	ATP binding site [chemical binding]; other site
435590000064	Mg2+ binding site [ion binding]; other site
435590000065	G-X-G motif; other site
435590000066	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
435590000067	elongation factor G; Reviewed; Region: PRK12740
435590000068	G1 box; other site
435590000069	putative GEF interaction site [polypeptide binding]; other site
435590000070	GTP/Mg2+ binding site [chemical binding]; other site
435590000071	Switch I region; other site
435590000072	G2 box; other site
435590000073	G3 box; other site
435590000074	Switch II region; other site
435590000075	G4 box; other site
435590000076	G5 box; other site
435590000077	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
435590000078	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
435590000079	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
435590000080	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
435590000081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000082	FeS/SAM binding site; other site
435590000083	HemN C-terminal domain; Region: HemN_C; pfam06969
435590000084	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590000085	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000086	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000087	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590000088	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000089	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590000090	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000091	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590000092	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000093	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000095	DNA binding residues [nucleotide binding]
435590000096	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000097	FecR protein; Region: FecR; pfam04773
435590000098	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000099	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000100	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590000101	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590000102	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590000103	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590000104	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590000105	Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488
435590000106	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
435590000107	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590000108	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
435590000109	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590000110	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590000111	active site
435590000112	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
435590000113	substrate binding site [chemical binding]; other site
435590000114	active site
435590000115	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
435590000116	metal binding site [ion binding]; metal-binding site
435590000117	ligand binding site [chemical binding]; other site
435590000118	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
435590000119	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
435590000120	Putative esterase; Region: Esterase; pfam00756
435590000121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
435590000122	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000123	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000126	dimer interface [polypeptide binding]; other site
435590000127	phosphorylation site [posttranslational modification]
435590000128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000129	ATP binding site [chemical binding]; other site
435590000130	Mg2+ binding site [ion binding]; other site
435590000131	G-X-G motif; other site
435590000132	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590000133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000134	active site
435590000135	phosphorylation site [posttranslational modification]
435590000136	intermolecular recognition site; other site
435590000137	dimerization interface [polypeptide binding]; other site
435590000138	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000140	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590000141	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590000142	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590000143	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590000144	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590000145	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590000146	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000147	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000148	SusD family; Region: SusD; pfam07980
435590000149	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000150	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000151	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000152	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000153	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590000154	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
435590000155	inhibitor binding site; inhibition site
435590000156	active site
435590000157	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
435590000158	substrate binding site [chemical binding]; other site
435590000159	active site
435590000160	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
435590000161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
435590000162	Transposase; Region: DEDD_Tnp_IS110; pfam01548
435590000163	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
435590000164	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
435590000165	MFS/sugar transport protein; Region: MFS_2; pfam13347
435590000166	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
435590000167	active site
435590000168	catalytic residues [active]
435590000169	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590000170	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000171	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
435590000172	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
435590000173	active site
435590000174	substrate binding site [chemical binding]; other site
435590000175	metal binding site [ion binding]; metal-binding site
435590000176	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
435590000177	DHH family; Region: DHH; pfam01368
435590000178	DHHA1 domain; Region: DHHA1; pfam02272
435590000179	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
435590000180	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
435590000181	Competence protein; Region: Competence; pfam03772
435590000182	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
435590000183	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
435590000184	substrate binding site [chemical binding]; other site
435590000185	hexamer interface [polypeptide binding]; other site
435590000186	metal binding site [ion binding]; metal-binding site
435590000187	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590000188	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590000189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000191	DNA binding residues [nucleotide binding]
435590000192	NigD-like protein; Region: NigD; pfam12667
435590000193	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
435590000194	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
435590000195	putative active site [active]
435590000196	substrate binding site [chemical binding]; other site
435590000197	putative cosubstrate binding site; other site
435590000198	catalytic site [active]
435590000199	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
435590000200	substrate binding site [chemical binding]; other site
435590000201	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
435590000202	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
435590000203	Cl- selectivity filter; other site
435590000204	Cl- binding residues [ion binding]; other site
435590000205	pore gating glutamate residue; other site
435590000206	dimer interface [polypeptide binding]; other site
435590000207	FOG: CBS domain [General function prediction only]; Region: COG0517
435590000208	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
435590000209	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
435590000210	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
435590000211	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
435590000212	active site
435590000213	dimer interface [polypeptide binding]; other site
435590000214	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
435590000215	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000216	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000217	Outer membrane efflux protein; Region: OEP; pfam02321
435590000218	Outer membrane efflux protein; Region: OEP; pfam02321
435590000219	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590000220	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000221	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000222	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000223	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000224	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
435590000225	O-Antigen ligase; Region: Wzy_C; pfam04932
435590000226	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
435590000227	signal peptidase I; Provisional; Region: PRK10861
435590000228	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000229	Catalytic site [active]
435590000230	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000231	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
435590000232	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590000233	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590000234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
435590000235	DNA binding site [nucleotide binding]
435590000236	L-aspartate dehydrogenase; Reviewed; Region: PRK13304
435590000237	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
435590000238	Domain of unknown function DUF108; Region: DUF108; pfam01958
435590000239	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_9; cd12170
435590000240	putative ligand binding site [chemical binding]; other site
435590000241	putative NAD binding site [chemical binding]; other site
435590000242	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
435590000243	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
435590000244	putative metal binding site [ion binding]; other site
435590000245	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590000246	HSP70 interaction site [polypeptide binding]; other site
435590000247	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
435590000248	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
435590000249	G1 box; other site
435590000250	putative GEF interaction site [polypeptide binding]; other site
435590000251	GTP/Mg2+ binding site [chemical binding]; other site
435590000252	Switch I region; other site
435590000253	G2 box; other site
435590000254	G3 box; other site
435590000255	Switch II region; other site
435590000256	G4 box; other site
435590000257	G5 box; other site
435590000258	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
435590000259	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
435590000260	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
435590000261	NADP binding site [chemical binding]; other site
435590000262	active site
435590000263	putative substrate binding site [chemical binding]; other site
435590000264	LysE type translocator; Region: LysE; cl00565
435590000265	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
435590000266	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
435590000267	dimerization interface [polypeptide binding]; other site
435590000268	ATP binding site [chemical binding]; other site
435590000269	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
435590000270	dimerization interface [polypeptide binding]; other site
435590000271	ATP binding site [chemical binding]; other site
435590000272	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
435590000273	putative active site [active]
435590000274	catalytic triad [active]
435590000275	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000278	dimer interface [polypeptide binding]; other site
435590000279	phosphorylation site [posttranslational modification]
435590000280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000281	ATP binding site [chemical binding]; other site
435590000282	Mg2+ binding site [ion binding]; other site
435590000283	G-X-G motif; other site
435590000284	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590000285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000286	active site
435590000287	phosphorylation site [posttranslational modification]
435590000288	intermolecular recognition site; other site
435590000289	dimerization interface [polypeptide binding]; other site
435590000290	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000291	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000292	Chromate transporter; Region: Chromate_transp; pfam02417
435590000293	Chromate transporter; Region: Chromate_transp; pfam02417
435590000294	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
435590000295	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
435590000296	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
435590000297	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
435590000298	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
435590000299	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590000300	putative catalytic site [active]
435590000301	putative metal binding site [ion binding]; other site
435590000302	putative phosphate binding site [ion binding]; other site
435590000303	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590000304	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590000305	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590000306	active site
435590000307	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
435590000308	PA14 domain; Region: PA14; pfam07691
435590000309	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
435590000310	Carbon starvation protein CstA; Region: CstA; pfam02554
435590000311	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
435590000312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
435590000313	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
435590000314	Virulence protein [General function prediction only]; Region: COG3943
435590000315	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590000316	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
435590000317	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
435590000318	dimerization interface [polypeptide binding]; other site
435590000319	ATP binding site [chemical binding]; other site
435590000320	peptide chain release factor 1; Validated; Region: prfA; PRK00591
435590000321	This domain is found in peptide chain release factors; Region: PCRF; smart00937
435590000322	RF-1 domain; Region: RF-1; pfam00472
435590000323	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
435590000324	active site
435590000325	dimer interface [polypeptide binding]; other site
435590000326	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
435590000327	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590000328	Zn2+ binding site [ion binding]; other site
435590000329	Mg2+ binding site [ion binding]; other site
435590000330	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
435590000331	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
435590000332	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
435590000333	trimer interface [polypeptide binding]; other site
435590000334	active site
435590000335	UDP-GlcNAc binding site [chemical binding]; other site
435590000336	lipid binding site [chemical binding]; lipid-binding site
435590000337	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
435590000338	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
435590000339	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
435590000340	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
435590000341	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
435590000342	active site
435590000343	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
435590000344	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
435590000345	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
435590000346	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
435590000347	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590000348	Right handed beta helix region; Region: Beta_helix; pfam13229
435590000349	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590000350	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590000351	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000352	SusD family; Region: SusD; pfam07980
435590000353	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590000354	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000355	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000356	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000357	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000358	FecR protein; Region: FecR; pfam04773
435590000359	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000361	DNA binding residues [nucleotide binding]
435590000362	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590000363	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590000364	catalytic residues [active]
435590000365	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590000366	AhpC/TSA family; Region: AhpC-TSA; pfam00578
435590000367	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590000368	TPR repeat; Region: TPR_11; pfam13414
435590000369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590000370	binding surface
435590000371	TPR motif; other site
435590000372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590000373	binding surface
435590000374	TPR motif; other site
435590000375	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
435590000376	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000377	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590000378	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590000379	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590000380	Penicillinase repressor; Region: Pencillinase_R; pfam03965
435590000381	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000382	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590000383	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590000384	active site
435590000385	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000386	Beta-lactamase; Region: Beta-lactamase; pfam00144
435590000387	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
435590000388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590000389	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590000390	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
435590000391	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
435590000392	active site
435590000393	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590000394	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590000395	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
435590000396	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000397	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000398	SusD family; Region: SusD; pfam07980
435590000399	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000400	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000401	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000402	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000403	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000404	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000405	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
435590000406	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000407	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000408	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590000409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000410	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
435590000411	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590000412	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
435590000413	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
435590000414	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
435590000415	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590000416	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590000417	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000418	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000419	SusD family; Region: SusD; pfam07980
435590000420	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000421	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000422	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000423	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590000424	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000425	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000426	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000427	DNA binding residues [nucleotide binding]
435590000428	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000429	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000430	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000431	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000432	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
435590000433	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
435590000434	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
435590000435	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
435590000436	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
435590000437	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
435590000438	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
435590000439	dimerization interface [polypeptide binding]; other site
435590000440	active site
435590000441	aspartate aminotransferase; Provisional; Region: PRK05764
435590000442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590000443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590000444	homodimer interface [polypeptide binding]; other site
435590000445	catalytic residue [active]
435590000446	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
435590000447	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590000448	Beta-lactamase; Region: Beta-lactamase; cl17358
435590000449	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
435590000450	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
435590000451	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590000452	active site
435590000453	metal binding site [ion binding]; metal-binding site
435590000454	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
435590000455	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
435590000456	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000457	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000458	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000460	dimer interface [polypeptide binding]; other site
435590000461	phosphorylation site [posttranslational modification]
435590000462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000463	ATP binding site [chemical binding]; other site
435590000464	Mg2+ binding site [ion binding]; other site
435590000465	G-X-G motif; other site
435590000466	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590000467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000468	active site
435590000469	phosphorylation site [posttranslational modification]
435590000470	intermolecular recognition site; other site
435590000471	dimerization interface [polypeptide binding]; other site
435590000472	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000473	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000474	Domain of unknown function (DUF718); Region: DUF718; pfam05336
435590000475	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000476	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000477	metal binding site [ion binding]; metal-binding site
435590000478	active site
435590000479	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590000480	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000481	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590000482	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
435590000483	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
435590000484	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000485	Transposase [DNA replication, recombination, and repair]; Region: COG5433
435590000486	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590000487	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590000488	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000489	active site
435590000490	catalytic triad [active]
435590000491	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000492	active site
435590000493	catalytic triad [active]
435590000494	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000495	metal binding site [ion binding]; metal-binding site
435590000496	active site
435590000497	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590000498	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000499	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590000500	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590000501	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590000502	Sulfatase; Region: Sulfatase; pfam00884
435590000503	translocation protein TolB; Provisional; Region: tolB; PRK04792
435590000504	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000505	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000506	SusD family; Region: SusD; pfam07980
435590000507	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000508	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000509	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000510	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590000511	DNA binding site [nucleotide binding]
435590000512	Int/Topo IB signature motif; other site
435590000513	active site
435590000514	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000515	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000516	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590000517	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000518	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000519	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000520	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000521	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000522	SusD family; Region: SusD; pfam07980
435590000523	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000524	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
435590000525	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000526	metal binding site [ion binding]; metal-binding site
435590000527	Family description; Region: VCBS; pfam13517
435590000528	active site
435590000529	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000530	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000531	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
435590000532	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
435590000533	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
435590000534	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590000535	active site
435590000536	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590000537	active site
435590000538	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590000539	sugar binding site [chemical binding]; other site
435590000540	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590000541	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000542	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590000543	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000544	active site
435590000545	catalytic triad [active]
435590000546	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590000547	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000548	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747
435590000549	homodimer interface [polypeptide binding]; other site
435590000550	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000551	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590000552	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
435590000553	catalytic nucleophile [active]
435590000554	Domain of unknown function (DUF718); Region: DUF718; pfam05336
435590000555	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
435590000556	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
435590000557	nucleotide binding site [chemical binding]; other site
435590000558	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
435590000559	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590000560	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590000561	Walker A/P-loop; other site
435590000562	ATP binding site [chemical binding]; other site
435590000563	Q-loop/lid; other site
435590000564	ABC transporter signature motif; other site
435590000565	Walker B; other site
435590000566	D-loop; other site
435590000567	H-loop/switch region; other site
435590000568	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590000569	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590000570	FtsX-like permease family; Region: FtsX; pfam02687
435590000571	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590000572	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590000573	FtsX-like permease family; Region: FtsX; pfam02687
435590000574	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000575	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590000576	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000577	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
435590000578	Transposase domain (DUF772); Region: DUF772; pfam05598
435590000579	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590000580	large tegument protein UL36; Provisional; Region: PHA03247
435590000581	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
435590000582	S1 domain; Region: S1_2; pfam13509
435590000583	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
435590000584	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
435590000585	dimer interface [polypeptide binding]; other site
435590000586	active site
435590000587	metal binding site [ion binding]; metal-binding site
435590000588	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
435590000589	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590000590	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590000591	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590000592	Walker A/P-loop; other site
435590000593	ATP binding site [chemical binding]; other site
435590000594	Q-loop/lid; other site
435590000595	ABC transporter signature motif; other site
435590000596	Walker B; other site
435590000597	D-loop; other site
435590000598	H-loop/switch region; other site
435590000599	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
435590000600	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
435590000601	putative ATP binding site [chemical binding]; other site
435590000602	putative substrate interface [chemical binding]; other site
435590000603	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590000604	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
435590000605	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
435590000606	Ligand Binding Site [chemical binding]; other site
435590000607	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
435590000608	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
435590000609	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
435590000610	glycyl-tRNA synthetase; Provisional; Region: PRK04173
435590000611	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
435590000612	motif 1; other site
435590000613	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
435590000614	active site
435590000615	motif 2; other site
435590000616	motif 3; other site
435590000617	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
435590000618	anticodon binding site; other site
435590000619	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
435590000620	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
435590000621	CAP-like domain; other site
435590000622	active site
435590000623	primary dimer interface [polypeptide binding]; other site
435590000624	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
435590000625	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
435590000626	active site triad [active]
435590000627	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
435590000628	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
435590000629	putative active site [active]
435590000630	putative catalytic site [active]
435590000631	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000632	Domain of unknown function (DUF718); Region: DUF718; cl01281
435590000633	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000634	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000635	SusD family; Region: SusD; pfam07980
435590000636	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000637	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000638	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000639	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000640	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
435590000641	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590000642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000643	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000645	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590000646	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
435590000647	active site
435590000648	catalytic tetrad [active]
435590000649	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
435590000650	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
435590000651	active site
435590000652	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590000653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590000654	putative substrate translocation pore; other site
435590000655	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
435590000656	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
435590000657	putative NAD(P) binding site [chemical binding]; other site
435590000658	catalytic Zn binding site [ion binding]; other site
435590000659	structural Zn binding site [ion binding]; other site
435590000660	MarC family integral membrane protein; Region: MarC; pfam01914
435590000661	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590000662	trimer interface [polypeptide binding]; other site
435590000663	active site
435590000664	substrate binding site [chemical binding]; other site
435590000665	CoA binding site [chemical binding]; other site
435590000666	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
435590000667	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
435590000668	active site
435590000669	catalytic triad [active]
435590000670	oxyanion hole [active]
435590000671	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590000672	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
435590000673	active site
435590000674	catalytic triad [active]
435590000675	oxyanion hole [active]
435590000676	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590000677	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000678	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000679	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590000680	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000681	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590000682	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
435590000683	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
435590000684	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
435590000685	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
435590000686	active site
435590000687	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590000688	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590000689	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000690	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590000691	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000692	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
435590000693	Malic enzyme, N-terminal domain; Region: malic; pfam00390
435590000694	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
435590000695	putative NAD(P) binding site [chemical binding]; other site
435590000696	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
435590000697	glutamate dehydrogenase; Provisional; Region: PRK14031
435590000698	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
435590000699	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
435590000700	NAD(P) binding site [chemical binding]; other site
435590000701	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
435590000702	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590000703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000704	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590000705	intermolecular recognition site; other site
435590000706	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590000707	glutamate dehydrogenase; Provisional; Region: PRK14030
435590000708	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
435590000709	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
435590000710	NAD(P) binding site [chemical binding]; other site
435590000711	pyruvate dehydrogenase; Provisional; Region: PRK09124
435590000712	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
435590000713	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590000714	Active Sites [active]
435590000715	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
435590000716	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
435590000717	ParB-like nuclease domain; Region: ParB; smart00470
435590000718	malate dehydrogenase; Reviewed; Region: PRK06223
435590000719	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
435590000720	dimer interface [polypeptide binding]; other site
435590000721	NAD(P) binding site [chemical binding]; other site
435590000722	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590000723	substrate binding site [chemical binding]; other site
435590000724	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
435590000725	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
435590000726	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590000727	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000728	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590000729	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590000730	ABC-2 type transporter; Region: ABC2_membrane; cl17235
435590000731	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590000732	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590000733	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
435590000734	NlpE N-terminal domain; Region: NlpE; pfam04170
435590000735	Penicillinase repressor; Region: Pencillinase_R; pfam03965
435590000736	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
435590000737	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590000738	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590000739	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590000740	Domain of unknown function DUF59; Region: DUF59; pfam01883
435590000741	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
435590000742	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
435590000743	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
435590000744	Protein of unknown function (DUF975); Region: DUF975; cl10504
435590000745	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
435590000746	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
435590000747	homodimer interface [polypeptide binding]; other site
435590000748	substrate-cofactor binding pocket; other site
435590000749	catalytic residue [active]
435590000750	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
435590000751	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
435590000752	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
435590000753	generic binding surface II; other site
435590000754	generic binding surface I; other site
435590000755	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
435590000756	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
435590000757	active site
435590000758	catalytic triad [active]
435590000759	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
435590000760	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590000761	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
435590000762	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590000764	binding surface
435590000765	TPR motif; other site
435590000766	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590000767	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
435590000768	putative active site [active]
435590000769	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000771	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000772	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000773	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590000774	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000775	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000776	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000777	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590000778	FeS/SAM binding site; other site
435590000779	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
435590000780	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590000781	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000782	FeS/SAM binding site; other site
435590000783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590000784	binding surface
435590000785	TPR motif; other site
435590000786	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590000788	binding surface
435590000789	TPR motif; other site
435590000790	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000791	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590000792	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
435590000793	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
435590000794	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
435590000795	putative active site [active]
435590000796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
435590000797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590000798	Walker A/P-loop; other site
435590000799	ATP binding site [chemical binding]; other site
435590000800	Q-loop/lid; other site
435590000801	ABC transporter signature motif; other site
435590000802	Walker B; other site
435590000803	D-loop; other site
435590000804	H-loop/switch region; other site
435590000805	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000806	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
435590000807	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000808	FeS/SAM binding site; other site
435590000809	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
435590000810	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
435590000811	putative active site [active]
435590000812	polyphosphate kinase; Provisional; Region: PRK05443
435590000813	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
435590000814	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
435590000815	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
435590000816	domain interface [polypeptide binding]; other site
435590000817	active site
435590000818	catalytic site [active]
435590000819	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
435590000820	domain interface [polypeptide binding]; other site
435590000821	active site
435590000822	catalytic site [active]
435590000823	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
435590000824	active site
435590000825	metal binding site [ion binding]; metal-binding site
435590000826	homotetramer interface [polypeptide binding]; other site
435590000827	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
435590000828	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
435590000829	NAD binding site [chemical binding]; other site
435590000830	substrate binding site [chemical binding]; other site
435590000831	homodimer interface [polypeptide binding]; other site
435590000832	active site
435590000833	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000834	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000835	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000836	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590000837	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000838	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000839	SusD family; Region: SusD; pfam07980
435590000840	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590000841	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590000842	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000843	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590000844	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590000845	alpha-glucosidase; Provisional; Region: PRK10137
435590000846	Trehalase; Region: Trehalase; cl17346
435590000847	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000848	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590000849	SusD family; Region: SusD; pfam07980
435590000850	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590000851	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000852	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590000853	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590000854	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000855	FecR protein; Region: FecR; pfam04773
435590000856	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000857	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000858	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000859	DNA binding residues [nucleotide binding]
435590000860	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590000861	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590000862	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590000863	ABC transporter; Region: ABC_tran_2; pfam12848
435590000864	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590000865	putative transporter; Validated; Region: PRK03818
435590000866	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590000867	TrkA-C domain; Region: TrkA_C; pfam02080
435590000868	TrkA-C domain; Region: TrkA_C; pfam02080
435590000869	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
435590000870	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
435590000871	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
435590000872	heterodimer interface [polypeptide binding]; other site
435590000873	substrate interaction site [chemical binding]; other site
435590000874	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
435590000875	B12 binding site [chemical binding]; other site
435590000876	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
435590000877	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
435590000878	active site
435590000879	substrate binding site [chemical binding]; other site
435590000880	coenzyme B12 binding site [chemical binding]; other site
435590000881	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
435590000882	B12 binding site [chemical binding]; other site
435590000883	cobalt ligand [ion binding]; other site
435590000884	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590000885	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000886	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590000887	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
435590000888	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590000889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000891	ATP binding site [chemical binding]; other site
435590000892	Mg2+ binding site [ion binding]; other site
435590000893	G-X-G motif; other site
435590000894	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
435590000895	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590000896	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590000897	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000898	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590000899	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590000900	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590000901	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590000902	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000903	NVEALA protein; Region: NVEALA; pfam14055
435590000904	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
435590000905	Ligand binding site [chemical binding]; other site
435590000906	Electron transfer flavoprotein domain; Region: ETF; pfam01012
435590000907	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
435590000908	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
435590000909	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
435590000910	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
435590000911	four helix bundle protein; Region: TIGR02436
435590000912	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
435590000913	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
435590000914	active site
435590000915	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
435590000916	Histidine carboxylase PI chain; Region: HDC; cl03540
435590000917	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590000918	CoenzymeA binding site [chemical binding]; other site
435590000919	subunit interaction site [polypeptide binding]; other site
435590000920	PHB binding site; other site
435590000921	Domain of unknown function (DUF2027); Region: DUF2027; pfam09640
435590000922	Smr domain; Region: Smr; pfam01713
435590000923	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
435590000924	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
435590000925	urocanate hydratase; Provisional; Region: PRK05414
435590000926	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
435590000927	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
435590000928	Formiminotransferase domain; Region: FTCD; pfam02971
435590000929	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366
435590000930	imidazolonepropionase; Validated; Region: PRK09356
435590000931	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
435590000932	active site
435590000933	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
435590000934	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
435590000935	active sites [active]
435590000936	tetramer interface [polypeptide binding]; other site
435590000937	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
435590000938	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
435590000939	nudix motif; other site
435590000940	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590000941	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590000942	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
435590000943	active site clefts [active]
435590000944	zinc binding site [ion binding]; other site
435590000945	dimer interface [polypeptide binding]; other site
435590000946	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590000947	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590000948	ligand binding site [chemical binding]; other site
435590000949	flexible hinge region; other site
435590000950	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590000951	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
435590000952	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
435590000953	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
435590000954	ring oligomerisation interface [polypeptide binding]; other site
435590000955	ATP/Mg binding site [chemical binding]; other site
435590000956	stacking interactions; other site
435590000957	hinge regions; other site
435590000958	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
435590000959	oligomerisation interface [polypeptide binding]; other site
435590000960	mobile loop; other site
435590000961	roof hairpin; other site
435590000962	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
435590000963	4Fe-4S binding domain; Region: Fer4; pfam00037
435590000964	4Fe-4S binding domain; Region: Fer4; pfam00037
435590000965	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
435590000966	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
435590000967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000968	FeS/SAM binding site; other site
435590000969	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
435590000970	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
435590000971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000972	FeS/SAM binding site; other site
435590000973	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
435590000974	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
435590000975	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
435590000976	G1 box; other site
435590000977	GTP/Mg2+ binding site [chemical binding]; other site
435590000978	Switch I region; other site
435590000979	G2 box; other site
435590000980	Switch II region; other site
435590000981	G3 box; other site
435590000982	G4 box; other site
435590000983	G5 box; other site
435590000984	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
435590000985	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
435590000986	dimer interface [polypeptide binding]; other site
435590000987	motif 1; other site
435590000988	active site
435590000989	motif 2; other site
435590000990	motif 3; other site
435590000991	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
435590000992	anticodon binding site; other site
435590000993	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
435590000994	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590000995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590000996	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
435590000997	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
435590000998	ligand binding site [chemical binding]; other site
435590000999	Ureide permease; Region: Ureide_permease; pfam07168
435590001000	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
435590001001	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
435590001002	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
435590001003	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590001004	substrate binding site [chemical binding]; other site
435590001005	trimer interface [polypeptide binding]; other site
435590001006	Mn binding site [ion binding]; other site
435590001007	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
435590001008	Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427
435590001009	N- and C-terminal domain interface [polypeptide binding]; other site
435590001010	active site
435590001011	MgATP binding site [chemical binding]; other site
435590001012	catalytic site [active]
435590001013	metal binding site [ion binding]; metal-binding site
435590001014	putative glycerol binding site [chemical binding]; other site
435590001015	putative homotetramer interface [polypeptide binding]; other site
435590001016	putative homodimer interface [polypeptide binding]; other site
435590001017	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
435590001018	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590001019	PYR/PP interface [polypeptide binding]; other site
435590001020	dimer interface [polypeptide binding]; other site
435590001021	TPP binding site [chemical binding]; other site
435590001022	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590001023	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
435590001024	TPP-binding site [chemical binding]; other site
435590001025	dimer interface [polypeptide binding]; other site
435590001026	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
435590001027	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
435590001028	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
435590001029	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
435590001030	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
435590001031	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590001032	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001033	Two component regulator propeller; Region: Reg_prop; pfam07494
435590001034	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001035	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001037	dimer interface [polypeptide binding]; other site
435590001038	phosphorylation site [posttranslational modification]
435590001039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001040	ATP binding site [chemical binding]; other site
435590001041	Mg2+ binding site [ion binding]; other site
435590001042	G-X-G motif; other site
435590001043	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590001044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001045	active site
435590001046	phosphorylation site [posttranslational modification]
435590001047	intermolecular recognition site; other site
435590001048	dimerization interface [polypeptide binding]; other site
435590001049	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001050	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001051	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001052	SusD family; Region: SusD; pfam07980
435590001053	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590001054	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001055	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001056	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001057	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590001058	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001059	FecR protein; Region: FecR; pfam04773
435590001060	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001062	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001063	DNA binding residues [nucleotide binding]
435590001064	Trehalase; Region: Trehalase; cl17346
435590001065	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590001066	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590001067	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590001068	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590001069	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590001070	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590001071	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
435590001072	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001073	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590001074	active site
435590001075	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590001076	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590001077	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590001078	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
435590001079	active site
435590001080	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
435590001081	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590001082	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590001083	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590001084	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
435590001085	putative efflux protein, MATE family; Region: matE; TIGR00797
435590001086	cation binding site [ion binding]; other site
435590001087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001089	dimer interface [polypeptide binding]; other site
435590001090	phosphorylation site [posttranslational modification]
435590001091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001092	ATP binding site [chemical binding]; other site
435590001093	Mg2+ binding site [ion binding]; other site
435590001094	G-X-G motif; other site
435590001095	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001097	active site
435590001098	phosphorylation site [posttranslational modification]
435590001099	intermolecular recognition site; other site
435590001100	dimerization interface [polypeptide binding]; other site
435590001101	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590001102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001103	active site
435590001104	phosphorylation site [posttranslational modification]
435590001105	intermolecular recognition site; other site
435590001106	dimerization interface [polypeptide binding]; other site
435590001107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001108	Walker A motif; other site
435590001109	ATP binding site [chemical binding]; other site
435590001110	Walker B motif; other site
435590001111	arginine finger; other site
435590001112	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590001113	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590001114	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590001115	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
435590001116	active site
435590001117	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
435590001118	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
435590001119	NAD(P) binding site [chemical binding]; other site
435590001120	homotetramer interface [polypeptide binding]; other site
435590001121	homodimer interface [polypeptide binding]; other site
435590001122	active site
435590001123	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
435590001124	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
435590001125	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001126	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001127	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001128	DNA binding residues [nucleotide binding]
435590001129	FecR protein; Region: FecR; pfam04773
435590001130	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001131	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590001132	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001133	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001134	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001135	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590001136	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001137	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001138	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590001139	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
435590001140	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001141	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590001142	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590001143	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
435590001144	putative active site [active]
435590001145	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590001146	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001147	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590001148	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590001149	Sulfatase; Region: Sulfatase; pfam00884
435590001150	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
435590001151	putative dimer interface [polypeptide binding]; other site
435590001152	[2Fe-2S] cluster binding site [ion binding]; other site
435590001153	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
435590001154	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590001155	ATP binding site [chemical binding]; other site
435590001156	Mg++ binding site [ion binding]; other site
435590001157	motif III; other site
435590001158	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001159	nucleotide binding region [chemical binding]; other site
435590001160	ATP-binding site [chemical binding]; other site
435590001161	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590001162	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590001163	active site
435590001164	metal binding site [ion binding]; metal-binding site
435590001165	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
435590001166	PQQ-like domain; Region: PQQ_2; pfam13360
435590001167	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
435590001168	active site
435590001169	Trp docking motif [polypeptide binding]; other site
435590001170	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590001171	putative catalytic site [active]
435590001172	putative metal binding site [ion binding]; other site
435590001173	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590001174	putative catalytic site [active]
435590001175	putative phosphate binding site [ion binding]; other site
435590001176	putative phosphate binding site [ion binding]; other site
435590001177	putative metal binding site [ion binding]; other site
435590001178	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
435590001179	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
435590001180	dimer interface [polypeptide binding]; other site
435590001181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590001182	catalytic residue [active]
435590001183	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
435590001184	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590001185	Ligand Binding Site [chemical binding]; other site
435590001186	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590001187	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590001188	DNA binding residues [nucleotide binding]
435590001189	dimerization interface [polypeptide binding]; other site
435590001190	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
435590001191	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
435590001192	active site
435590001193	HIGH motif; other site
435590001194	dimer interface [polypeptide binding]; other site
435590001195	KMSKS motif; other site
435590001196	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
435590001197	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
435590001198	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
435590001199	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590001200	ATP-grasp domain; Region: ATP-grasp_4; cl17255
435590001201	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
435590001202	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590001203	ATP-grasp domain; Region: ATP-grasp_4; cl17255
435590001204	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
435590001205	probable substrate binding site [chemical binding]; other site
435590001206	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590001207	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590001208	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590001209	catalytic residues [active]
435590001210	hypothetical protein; Validated; Region: PRK02101
435590001211	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
435590001212	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590001213	ligand binding site [chemical binding]; other site
435590001214	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
435590001215	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
435590001216	CysD dimerization site [polypeptide binding]; other site
435590001217	G1 box; other site
435590001218	putative GEF interaction site [polypeptide binding]; other site
435590001219	GTP/Mg2+ binding site [chemical binding]; other site
435590001220	Switch I region; other site
435590001221	G2 box; other site
435590001222	G3 box; other site
435590001223	Switch II region; other site
435590001224	G4 box; other site
435590001225	G5 box; other site
435590001226	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
435590001227	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
435590001228	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
435590001229	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590001230	Active Sites [active]
435590001231	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
435590001232	ligand-binding site [chemical binding]; other site
435590001233	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
435590001234	transmembrane helices; other site
435590001235	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
435590001236	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
435590001237	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
435590001238	active site
435590001239	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590001240	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
435590001241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001242	ATP binding site [chemical binding]; other site
435590001243	Mg2+ binding site [ion binding]; other site
435590001244	G-X-G motif; other site
435590001245	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
435590001246	ATP binding site [chemical binding]; other site
435590001247	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
435590001248	OstA-like protein; Region: OstA_2; pfam13100
435590001249	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
435590001250	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
435590001251	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
435590001252	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
435590001253	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
435590001254	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
435590001255	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
435590001256	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
435590001257	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
435590001258	active site
435590001259	Virulence-associated protein E; Region: VirE; pfam05272
435590001260	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590001261	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
435590001262	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
435590001263	catalytic residues [active]
435590001264	catalytic nucleophile [active]
435590001265	Recombinase; Region: Recombinase; pfam07508
435590001266	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
435590001267	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
435590001268	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
435590001269	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590001270	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590001271	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590001272	active site
435590001273	DNA binding site [nucleotide binding]
435590001274	Int/Topo IB signature motif; other site
435590001275	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
435590001276	VirE N-terminal domain; Region: VirE_N; pfam08800
435590001277	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
435590001278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590001279	ATP binding site [chemical binding]; other site
435590001280	putative Mg++ binding site [ion binding]; other site
435590001281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001282	nucleotide binding region [chemical binding]; other site
435590001283	ATP-binding site [chemical binding]; other site
435590001284	RQC domain; Region: RQC; pfam09382
435590001285	HRDC domain; Region: HRDC; pfam00570
435590001286	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
435590001287	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
435590001288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001289	Walker A motif; other site
435590001290	ATP binding site [chemical binding]; other site
435590001291	Walker B motif; other site
435590001292	arginine finger; other site
435590001293	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
435590001294	Clp protease; Region: CLP_protease; pfam00574
435590001295	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
435590001296	oligomer interface [polypeptide binding]; other site
435590001297	active site residues [active]
435590001298	trigger factor; Region: tig; TIGR00115
435590001299	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
435590001300	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
435590001301	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
435590001302	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
435590001303	Walker A/P-loop; other site
435590001304	ATP binding site [chemical binding]; other site
435590001305	Q-loop/lid; other site
435590001306	ABC transporter signature motif; other site
435590001307	Walker B; other site
435590001308	D-loop; other site
435590001309	H-loop/switch region; other site
435590001310	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
435590001311	Permease; Region: Permease; pfam02405
435590001312	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
435590001313	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
435590001314	Walker A/P-loop; other site
435590001315	ATP binding site [chemical binding]; other site
435590001316	Q-loop/lid; other site
435590001317	ABC transporter signature motif; other site
435590001318	Walker B; other site
435590001319	D-loop; other site
435590001320	H-loop/switch region; other site
435590001321	GTP-binding protein Der; Reviewed; Region: PRK00093
435590001322	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
435590001323	G1 box; other site
435590001324	GTP/Mg2+ binding site [chemical binding]; other site
435590001325	Switch I region; other site
435590001326	G2 box; other site
435590001327	Switch II region; other site
435590001328	G3 box; other site
435590001329	G4 box; other site
435590001330	G5 box; other site
435590001331	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
435590001332	G1 box; other site
435590001333	GTP/Mg2+ binding site [chemical binding]; other site
435590001334	Switch I region; other site
435590001335	G2 box; other site
435590001336	G3 box; other site
435590001337	Switch II region; other site
435590001338	G4 box; other site
435590001339	G5 box; other site
435590001340	GTPase Era; Reviewed; Region: era; PRK00089
435590001341	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
435590001342	G1 box; other site
435590001343	GTP/Mg2+ binding site [chemical binding]; other site
435590001344	Switch I region; other site
435590001345	G2 box; other site
435590001346	Switch II region; other site
435590001347	G3 box; other site
435590001348	G4 box; other site
435590001349	G5 box; other site
435590001350	KH domain; Region: KH_2; pfam07650
435590001351	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
435590001352	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
435590001353	dimer interface [polypeptide binding]; other site
435590001354	active site
435590001355	CoA binding pocket [chemical binding]; other site
435590001356	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
435590001357	Transcriptional regulators [Transcription]; Region: MarR; COG1846
435590001358	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
435590001359	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
435590001360	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
435590001361	NAD(P) binding site [chemical binding]; other site
435590001362	LDH/MDH dimer interface [polypeptide binding]; other site
435590001363	substrate binding site [chemical binding]; other site
435590001364	DNA primase, catalytic core; Region: dnaG; TIGR01391
435590001365	CHC2 zinc finger; Region: zf-CHC2; pfam01807
435590001366	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
435590001367	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
435590001368	active site
435590001369	metal binding site [ion binding]; metal-binding site
435590001370	interdomain interaction site; other site
435590001371	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
435590001372	homodecamer interface [polypeptide binding]; other site
435590001373	GTP cyclohydrolase I; Provisional; Region: PLN03044
435590001374	active site
435590001375	putative catalytic site residues [active]
435590001376	zinc binding site [ion binding]; other site
435590001377	GTP-CH-I/GFRP interaction surface; other site
435590001378	Sporulation related domain; Region: SPOR; cl10051
435590001379	triosephosphate isomerase; Provisional; Region: PRK14567
435590001380	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
435590001381	substrate binding site [chemical binding]; other site
435590001382	dimer interface [polypeptide binding]; other site
435590001383	catalytic triad [active]
435590001384	DoxX; Region: DoxX; pfam07681
435590001385	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
435590001386	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
435590001387	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590001388	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590001389	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590001390	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
435590001391	active site
435590001392	multimer interface [polypeptide binding]; other site
435590001393	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
435590001394	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
435590001395	generic binding surface II; other site
435590001396	ssDNA binding site; other site
435590001397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590001398	ATP binding site [chemical binding]; other site
435590001399	putative Mg++ binding site [ion binding]; other site
435590001400	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001401	nucleotide binding region [chemical binding]; other site
435590001402	ATP-binding site [chemical binding]; other site
435590001403	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
435590001404	substrate binding site; other site
435590001405	dimer interface; other site
435590001406	DJ-1 family protein; Region: not_thiJ; TIGR01383
435590001407	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
435590001408	conserved cys residue [active]
435590001409	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590001410	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
435590001411	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
435590001412	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
435590001413	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
435590001414	active site
435590001415	hydrophilic channel; other site
435590001416	dimerization interface [polypeptide binding]; other site
435590001417	catalytic residues [active]
435590001418	active site lid [active]
435590001419	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911
435590001420	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
435590001421	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
435590001422	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590001423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590001424	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590001425	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590001426	exonuclease subunit SbcC; Provisional; Region: PRK10246
435590001427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590001428	Walker A/P-loop; other site
435590001429	ATP binding site [chemical binding]; other site
435590001430	Q-loop/lid; other site
435590001431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590001432	ABC transporter signature motif; other site
435590001433	Walker B; other site
435590001434	D-loop; other site
435590001435	H-loop/switch region; other site
435590001436	exonuclease subunit SbcD; Provisional; Region: PRK10966
435590001437	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
435590001438	active site
435590001439	metal binding site [ion binding]; metal-binding site
435590001440	DNA binding site [nucleotide binding]
435590001441	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
435590001442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590001443	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590001444	putative alpha-glucosidase; Provisional; Region: PRK10658
435590001445	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590001446	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
435590001447	putative active site [active]
435590001448	putative catalytic site [active]
435590001449	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001450	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001451	SusD family; Region: SusD; pfam07980
435590001452	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001453	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001454	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001455	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001456	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001457	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001459	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001461	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
435590001462	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590001463	sugar binding site [chemical binding]; other site
435590001464	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
435590001465	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
435590001466	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001467	active site
435590001468	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
435590001469	putative substrate binding site [chemical binding]; other site
435590001470	active site
435590001471	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590001472	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001473	SusD family; Region: SusD; pfam07980
435590001474	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590001475	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001476	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001477	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001478	FecR protein; Region: FecR; pfam04773
435590001479	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001480	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001481	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001483	DNA binding residues [nucleotide binding]
435590001484	PIF1-like helicase; Region: PIF1; pfam05970
435590001485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001486	Walker A motif; other site
435590001487	ATP binding site [chemical binding]; other site
435590001488	Walker B motif; other site
435590001489	Family description; Region: UvrD_C_2; pfam13538
435590001490	HRDC domain; Region: HRDC; pfam00570
435590001491	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001492	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001493	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001494	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001495	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001496	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001497	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
435590001498	active site
435590001499	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
435590001500	active site
435590001501	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590001502	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
435590001503	active site
435590001504	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001505	active site
435590001506	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001507	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001508	SusD family; Region: SusD; pfam07980
435590001509	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001510	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001511	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001512	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590001513	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001514	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001517	dimer interface [polypeptide binding]; other site
435590001518	phosphorylation site [posttranslational modification]
435590001519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001520	ATP binding site [chemical binding]; other site
435590001521	Mg2+ binding site [ion binding]; other site
435590001522	G-X-G motif; other site
435590001523	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590001524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001525	active site
435590001526	phosphorylation site [posttranslational modification]
435590001527	intermolecular recognition site; other site
435590001528	dimerization interface [polypeptide binding]; other site
435590001529	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590001530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001531	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
435590001532	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590001533	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
435590001534	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590001535	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
435590001536	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590001537	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590001538	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
435590001539	dihydropteroate synthase; Region: DHPS; TIGR01496
435590001540	substrate binding pocket [chemical binding]; other site
435590001541	dimer interface [polypeptide binding]; other site
435590001542	inhibitor binding site; inhibition site
435590001543	Uncharacterized conserved protein [Function unknown]; Region: COG1624
435590001544	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
435590001545	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
435590001546	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
435590001547	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
435590001548	LrgB-like family; Region: LrgB; pfam04172
435590001549	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
435590001550	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
435590001551	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
435590001552	propionate/acetate kinase; Provisional; Region: PRK12379
435590001553	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
435590001554	putative active site [active]
435590001555	putative metal binding site [ion binding]; other site
435590001556	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
435590001557	hypothetical protein; Reviewed; Region: PRK00024
435590001558	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590001559	MPN+ (JAMM) motif; other site
435590001560	Zinc-binding site [ion binding]; other site
435590001561	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590001562	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590001563	active site
435590001564	elongation factor P; Validated; Region: PRK00529
435590001565	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
435590001566	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
435590001567	RNA binding site [nucleotide binding]; other site
435590001568	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
435590001569	RNA binding site [nucleotide binding]; other site
435590001570	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
435590001571	anaerobic sulfatase-maturase; Provisional; Region: PRK13745
435590001572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590001573	FeS/SAM binding site; other site
435590001574	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
435590001575	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590001576	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
435590001577	active site
435590001578	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
435590001579	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590001580	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590001581	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590001582	sugar binding site [chemical binding]; other site
435590001583	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590001584	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590001585	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001586	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590001587	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590001588	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590001589	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590001590	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590001591	active site
435590001592	Fn3 associated; Region: Fn3_assoc; pfam13287
435590001593	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590001594	Sulfatase; Region: Sulfatase; cl17466
435590001595	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590001596	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001597	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001598	SusD family; Region: SusD; pfam07980
435590001599	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001600	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001601	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001602	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001603	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590001604	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590001605	sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827
435590001606	active site
435590001607	catalytic triad [active]
435590001608	oxyanion hole [active]
435590001609	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001612	dimer interface [polypeptide binding]; other site
435590001613	phosphorylation site [posttranslational modification]
435590001614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001615	ATP binding site [chemical binding]; other site
435590001616	G-X-G motif; other site
435590001617	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001619	active site
435590001620	phosphorylation site [posttranslational modification]
435590001621	intermolecular recognition site; other site
435590001622	dimerization interface [polypeptide binding]; other site
435590001623	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001625	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
435590001626	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
435590001627	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
435590001628	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
435590001629	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
435590001630	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590001631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590001632	RNA binding surface [nucleotide binding]; other site
435590001633	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
435590001634	active site
435590001635	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
435590001636	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
435590001637	ATP-grasp domain; Region: ATP-grasp_4; cl17255
435590001638	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
435590001639	putative acyl-acceptor binding pocket; other site
435590001640	NigD-like protein; Region: NigD; pfam12667
435590001641	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
435590001642	active site residue [active]
435590001643	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
435590001644	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
435590001645	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
435590001646	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
435590001647	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
435590001648	putative catalytic cysteine [active]
435590001649	gamma-glutamyl kinase; Provisional; Region: PRK05429
435590001650	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
435590001651	nucleotide binding site [chemical binding]; other site
435590001652	homotetrameric interface [polypeptide binding]; other site
435590001653	putative phosphate binding site [ion binding]; other site
435590001654	putative allosteric binding site; other site
435590001655	PUA domain; Region: PUA; pfam01472
435590001656	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
435590001657	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590001658	active site
435590001659	motif I; other site
435590001660	motif II; other site
435590001661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590001662	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001663	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590001664	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590001665	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
435590001666	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
435590001667	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001668	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001669	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001670	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001671	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001672	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001673	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001674	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001675	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001676	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001677	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001678	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
435590001679	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
435590001680	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
435590001681	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590001682	Virulence-associated protein E; Region: VirE; pfam05272
435590001683	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590001684	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001685	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001686	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001687	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001688	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590001689	AAA domain; Region: AAA_14; pfam13173
435590001690	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001691	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001692	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001693	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001694	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001695	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001696	Dihydro-orotase-like; Region: DHOase; pfam12890
435590001697	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590001698	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
435590001699	acyl-activating enzyme (AAE) consensus motif; other site
435590001700	AMP binding site [chemical binding]; other site
435590001701	active site
435590001702	CoA binding site [chemical binding]; other site
435590001703	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590001704	non-specific DNA binding site [nucleotide binding]; other site
435590001705	salt bridge; other site
435590001706	sequence-specific DNA binding site [nucleotide binding]; other site
435590001707	Cupin domain; Region: Cupin_2; pfam07883
435590001708	Domain of unknown function (DUF1893); Region: TM1506; pfam08973
435590001709	4Fe-4S binding domain; Region: Fer4_5; pfam12801
435590001710	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
435590001711	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590001712	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590001713	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
435590001714	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590001715	4Fe-4S binding domain; Region: Fer4; pfam00037
435590001716	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
435590001717	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590001718	active site
435590001719	catalytic tetrad [active]
435590001720	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
435590001721	Na binding site [ion binding]; other site
435590001722	Uncharacterized conserved protein [Function unknown]; Region: COG3379
435590001723	Sulfatase; Region: Sulfatase; cl17466
435590001724	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001725	active site
435590001726	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
435590001727	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590001728	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001729	SusD family; Region: SusD; pfam07980
435590001730	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001731	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001732	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001733	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590001734	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590001735	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590001736	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590001737	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590001738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001739	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
435590001740	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
435590001741	acetylornithine aminotransferase; Provisional; Region: PRK02627
435590001742	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
435590001743	inhibitor-cofactor binding pocket; inhibition site
435590001744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590001745	catalytic residue [active]
435590001746	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
435590001747	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
435590001748	argininosuccinate synthase; Provisional; Region: PRK13820
435590001749	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
435590001750	Ligand Binding Site [chemical binding]; other site
435590001751	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
435590001752	Coenzyme A binding pocket [chemical binding]; other site
435590001753	Arginine repressor [Transcription]; Region: ArgR; COG1438
435590001754	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
435590001755	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
435590001756	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
435590001757	N- and C-terminal domain interface [polypeptide binding]; other site
435590001758	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
435590001759	active site
435590001760	putative catalytic site [active]
435590001761	metal binding site [ion binding]; metal-binding site
435590001762	ATP binding site [chemical binding]; other site
435590001763	carbohydrate binding site [chemical binding]; other site
435590001764	L-rhamnose isomerase; Provisional; Region: PRK01076
435590001765	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
435590001766	rhamnose-proton symporter; Provisional; Region: PRK13499
435590001767	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
435590001768	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
435590001769	intersubunit interface [polypeptide binding]; other site
435590001770	active site
435590001771	Zn2+ binding site [ion binding]; other site
435590001772	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590001773	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001774	SusD family; Region: SusD; pfam07980
435590001775	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001776	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001777	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001778	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590001779	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001780	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001783	dimer interface [polypeptide binding]; other site
435590001784	phosphorylation site [posttranslational modification]
435590001785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001786	ATP binding site [chemical binding]; other site
435590001787	Mg2+ binding site [ion binding]; other site
435590001788	G-X-G motif; other site
435590001789	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590001790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001791	active site
435590001792	phosphorylation site [posttranslational modification]
435590001793	intermolecular recognition site; other site
435590001794	dimerization interface [polypeptide binding]; other site
435590001795	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001796	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001797	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
435590001798	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590001799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001800	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
435590001801	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590001802	catalytic residue [active]
435590001803	Ion transport protein; Region: Ion_trans; pfam00520
435590001804	Ion channel; Region: Ion_trans_2; pfam07885
435590001805	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
435590001806	Double zinc ribbon; Region: DZR; pfam12773
435590001807	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590001808	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590001809	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001810	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590001811	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590001812	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590001813	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590001814	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001815	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001816	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001817	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
435590001818	FecR protein; Region: FecR; pfam04773
435590001819	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590001820	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590001821	Domain of unknown function (DUF377); Region: DUF377; pfam04041
435590001822	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001823	active site
435590001824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590001825	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
435590001826	putative substrate translocation pore; other site
435590001827	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590001828	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590001829	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590001830	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590001831	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
435590001832	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
435590001833	active site
435590001834	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001835	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001836	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001837	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001838	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590001839	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001840	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590001841	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
435590001842	putative catalytic site [active]
435590001843	putative metal binding site [ion binding]; other site
435590001844	putative phosphate binding site [ion binding]; other site
435590001845	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001846	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001847	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590001848	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590001849	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001850	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590001851	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590001852	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001853	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590001854	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001855	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590001856	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001857	FecR protein; Region: FecR; pfam04773
435590001858	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001859	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001861	DNA binding residues [nucleotide binding]
435590001862	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001863	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590001864	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001865	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
435590001866	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
435590001867	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
435590001868	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
435590001869	Clp amino terminal domain; Region: Clp_N; pfam02861
435590001870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001871	Walker A motif; other site
435590001872	ATP binding site [chemical binding]; other site
435590001873	Walker B motif; other site
435590001874	arginine finger; other site
435590001875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001876	Walker A motif; other site
435590001877	ATP binding site [chemical binding]; other site
435590001878	Walker B motif; other site
435590001879	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
435590001880	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
435590001881	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
435590001882	putative efflux protein, MATE family; Region: matE; TIGR00797
435590001883	PAS fold; Region: PAS_3; pfam08447
435590001884	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590001885	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590001886	DNA binding residues [nucleotide binding]
435590001887	dimerization interface [polypeptide binding]; other site
435590001888	alpha-galactosidase; Region: PLN02808; cl17638
435590001889	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
435590001890	Ca binding site [ion binding]; other site
435590001891	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590001892	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590001893	Int/Topo IB signature motif; other site
435590001894	Domain of unknown function (DUF4120); Region: DUF4120; pfam13496
435590001895	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590001896	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590001897	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590001898	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590001899	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
435590001900	catalytic residue [active]
435590001901	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590001902	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590001903	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590001904	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590001905	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590001906	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590001907	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590001908	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590001909	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590001910	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590001911	Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992
435590001912	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590001913	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
435590001914	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590001915	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590001916	Uncharacterized conserved protein [Function unknown]; Region: COG1479
435590001917	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590001918	Uncharacterized conserved protein [Function unknown]; Region: COG4938
435590001919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590001920	Walker A/P-loop; other site
435590001921	ATP binding site [chemical binding]; other site
435590001922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590001923	Walker B; other site
435590001924	D-loop; other site
435590001925	H-loop/switch region; other site
435590001926	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
435590001927	Domain of unknown function (DUF4122); Region: DUF4122; pfam13498
435590001928	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590001929	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590001930	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590001931	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
435590001932	YWFCY protein; Region: YWFCY; pfam14293
435590001933	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590001934	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
435590001935	RibD C-terminal domain; Region: RibD_C; cl17279
435590001936	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590001937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001938	active site
435590001939	phosphorylation site [posttranslational modification]
435590001940	intermolecular recognition site; other site
435590001941	dimerization interface [polypeptide binding]; other site
435590001942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001943	Walker A motif; other site
435590001944	ATP binding site [chemical binding]; other site
435590001945	Walker B motif; other site
435590001946	arginine finger; other site
435590001947	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590001948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590001949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001950	dimer interface [polypeptide binding]; other site
435590001951	phosphorylation site [posttranslational modification]
435590001952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001953	ATP binding site [chemical binding]; other site
435590001954	Mg2+ binding site [ion binding]; other site
435590001955	G-X-G motif; other site
435590001956	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001958	active site
435590001959	phosphorylation site [posttranslational modification]
435590001960	intermolecular recognition site; other site
435590001961	dimerization interface [polypeptide binding]; other site
435590001962	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590001963	ATP binding site [chemical binding]; other site
435590001964	putative Mg++ binding site [ion binding]; other site
435590001965	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001966	nucleotide binding region [chemical binding]; other site
435590001967	ATP-binding site [chemical binding]; other site
435590001968	Helicase associated domain; Region: HA; pfam03457
435590001969	Helicase associated domain; Region: HA; pfam03457
435590001970	Helicase associated domain; Region: HA; pfam03457
435590001971	Helicase associated domain; Region: HA; pfam03457
435590001972	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590001973	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590001974	active site
435590001975	homodimer interface [polypeptide binding]; other site
435590001976	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590001977	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
435590001978	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
435590001979	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590001980	putative trimer interface [polypeptide binding]; other site
435590001981	putative CoA binding site [chemical binding]; other site
435590001982	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590001983	putative trimer interface [polypeptide binding]; other site
435590001984	putative CoA binding site [chemical binding]; other site
435590001985	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590001986	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590001987	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590001988	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590001989	active site
435590001990	homodimer interface [polypeptide binding]; other site
435590001991	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
435590001992	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
435590001993	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
435590001994	putative NAD(P) binding site [chemical binding]; other site
435590001995	active site
435590001996	putative substrate binding site [chemical binding]; other site
435590001997	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
435590001998	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
435590001999	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
435590002000	NAD(P) binding site [chemical binding]; other site
435590002001	homodimer interface [polypeptide binding]; other site
435590002002	substrate binding site [chemical binding]; other site
435590002003	active site
435590002004	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
435590002005	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590002006	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590002007	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590002008	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590002009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
435590002010	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
435590002011	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590002012	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
435590002013	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
435590002014	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
435590002015	Chain length determinant protein; Region: Wzz; cl15801
435590002016	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590002017	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590002018	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590002019	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590002020	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
435590002021	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590002022	Mg++ binding site [ion binding]; other site
435590002023	putative catalytic motif [active]
435590002024	substrate binding site [chemical binding]; other site
435590002025	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590002026	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
435590002027	homodimer interface [polypeptide binding]; other site
435590002028	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590002029	active site
435590002030	DNA binding site [nucleotide binding]
435590002031	Int/Topo IB signature motif; other site
435590002032	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590002033	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590002034	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590002035	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590002036	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590002037	DNA topoisomerase III; Provisional; Region: PRK07726
435590002038	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590002039	active site
435590002040	putative interdomain interaction site [polypeptide binding]; other site
435590002041	putative metal-binding site [ion binding]; other site
435590002042	putative nucleotide binding site [chemical binding]; other site
435590002043	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
435590002044	domain I; other site
435590002045	DNA binding groove [nucleotide binding]
435590002046	phosphate binding site [ion binding]; other site
435590002047	domain II; other site
435590002048	domain III; other site
435590002049	nucleotide binding site [chemical binding]; other site
435590002050	catalytic site [active]
435590002051	domain IV; other site
435590002052	PRTRC system protein E; Region: PRTRC_E; TIGR03741
435590002053	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
435590002054	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
435590002055	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
435590002056	ATP binding site [chemical binding]; other site
435590002057	substrate interface [chemical binding]; other site
435590002058	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
435590002059	putative metal binding site [ion binding]; other site
435590002060	Uncharacterized conserved protein [Function unknown]; Region: COG1432
435590002061	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
435590002062	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590002063	DNA binding residues [nucleotide binding]
435590002064	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590002065	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590002066	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590002067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590002068	Walker A motif; other site
435590002069	ATP binding site [chemical binding]; other site
435590002070	Walker B motif; other site
435590002071	Nuclease-related domain; Region: NERD; pfam08378
435590002072	AAA domain; Region: AAA_21; pfam13304
435590002073	RloB-like protein; Region: RloB; pfam13707
435590002074	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
435590002075	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
435590002076	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
435590002077	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590002078	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590002079	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590002080	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002081	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002082	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590002083	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002084	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002085	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002086	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590002087	FecR protein; Region: FecR; pfam04773
435590002088	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002089	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002090	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002091	DNA binding residues [nucleotide binding]
435590002092	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
435590002093	Melibiase; Region: Melibiase; pfam02065
435590002094	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
435590002095	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002096	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002098	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590002099	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590002100	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590002101	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002102	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002103	SusD family; Region: SusD; pfam07980
435590002104	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002105	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002106	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590002107	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590002108	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
435590002109	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
435590002110	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590002111	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590002112	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590002113	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
435590002114	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590002115	sugar binding site [chemical binding]; other site
435590002116	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590002117	active site
435590002118	catalytic residues [active]
435590002119	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002120	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002121	SusD family; Region: SusD; pfam07980
435590002122	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002123	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002124	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002125	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002126	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
435590002127	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002128	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002131	dimer interface [polypeptide binding]; other site
435590002132	phosphorylation site [posttranslational modification]
435590002133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002134	ATP binding site [chemical binding]; other site
435590002135	Mg2+ binding site [ion binding]; other site
435590002136	G-X-G motif; other site
435590002137	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590002138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002139	active site
435590002140	phosphorylation site [posttranslational modification]
435590002141	intermolecular recognition site; other site
435590002142	dimerization interface [polypeptide binding]; other site
435590002143	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002144	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002146	TPR motif; other site
435590002147	binding surface
435590002148	TPR repeat; Region: TPR_11; pfam13414
435590002149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002150	binding surface
435590002151	TPR motif; other site
435590002152	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590002153	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
435590002154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590002155	putative substrate translocation pore; other site
435590002156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590002157	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590002158	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590002159	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
435590002160	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590002161	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590002162	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590002163	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590002164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590002165	Walker A motif; other site
435590002166	ATP binding site [chemical binding]; other site
435590002167	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
435590002168	AAA domain; Region: AAA_30; pfam13604
435590002169	AAA domain; Region: AAA_12; pfam13087
435590002170	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
435590002171	PLD-like domain; Region: PLDc_2; pfam13091
435590002172	putative active site [active]
435590002173	catalytic site [active]
435590002174	Predicted membrane protein [Function unknown]; Region: COG2311
435590002175	Protein of unknown function (DUF418); Region: DUF418; pfam04235
435590002176	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
435590002177	AAA domain; Region: AAA_14; pfam13173
435590002178	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
435590002179	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
435590002180	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
435590002181	putative active site [active]
435590002182	metal binding site [ion binding]; metal-binding site
435590002183	Creatinine amidohydrolase; Region: Creatininase; pfam02633
435590002184	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002185	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002186	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002187	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002188	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002189	Domain of unknown function (DUF4221); Region: DUF4221; pfam13970
435590002190	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590002191	active site
435590002192	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590002193	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590002194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590002195	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
435590002196	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
435590002197	homodimer interface [polypeptide binding]; other site
435590002198	substrate-cofactor binding pocket; other site
435590002199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002200	catalytic residue [active]
435590002201	short chain dehydrogenase; Provisional; Region: PRK07024
435590002202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002203	NAD(P) binding site [chemical binding]; other site
435590002204	active site
435590002205	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590002206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002207	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002208	DNA binding residues [nucleotide binding]
435590002209	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
435590002210	MutS domain III; Region: MutS_III; pfam05192
435590002211	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
435590002212	Walker A/P-loop; other site
435590002213	ATP binding site [chemical binding]; other site
435590002214	Q-loop/lid; other site
435590002215	ABC transporter signature motif; other site
435590002216	Walker B; other site
435590002217	D-loop; other site
435590002218	H-loop/switch region; other site
435590002219	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
435590002220	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
435590002221	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
435590002222	alphaNTD - beta interaction site [polypeptide binding]; other site
435590002223	alphaNTD homodimer interface [polypeptide binding]; other site
435590002224	alphaNTD - beta' interaction site [polypeptide binding]; other site
435590002225	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
435590002226	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
435590002227	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
435590002228	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590002229	RNA binding surface [nucleotide binding]; other site
435590002230	30S ribosomal protein S11; Validated; Region: PRK05309
435590002231	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
435590002232	30S ribosomal protein S13; Region: bact_S13; TIGR03631
435590002233	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
435590002234	rRNA binding site [nucleotide binding]; other site
435590002235	predicted 30S ribosome binding site; other site
435590002236	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
435590002237	active site
435590002238	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
435590002239	SecY translocase; Region: SecY; pfam00344
435590002240	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
435590002241	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
435590002242	23S rRNA binding site [nucleotide binding]; other site
435590002243	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
435590002244	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
435590002245	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
435590002246	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
435590002247	5S rRNA interface [nucleotide binding]; other site
435590002248	L27 interface [polypeptide binding]; other site
435590002249	23S rRNA interface [nucleotide binding]; other site
435590002250	L5 interface [polypeptide binding]; other site
435590002251	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
435590002252	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
435590002253	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
435590002254	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
435590002255	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
435590002256	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
435590002257	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
435590002258	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
435590002259	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
435590002260	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
435590002261	RNA binding site [nucleotide binding]; other site
435590002262	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
435590002263	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
435590002264	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
435590002265	23S rRNA interface [nucleotide binding]; other site
435590002266	putative translocon interaction site; other site
435590002267	signal recognition particle (SRP54) interaction site; other site
435590002268	L23 interface [polypeptide binding]; other site
435590002269	trigger factor interaction site; other site
435590002270	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
435590002271	23S rRNA interface [nucleotide binding]; other site
435590002272	5S rRNA interface [nucleotide binding]; other site
435590002273	putative antibiotic binding site [chemical binding]; other site
435590002274	L25 interface [polypeptide binding]; other site
435590002275	L27 interface [polypeptide binding]; other site
435590002276	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
435590002277	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
435590002278	G-X-X-G motif; other site
435590002279	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
435590002280	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
435590002281	putative translocon binding site; other site
435590002282	protein-rRNA interface [nucleotide binding]; other site
435590002283	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
435590002284	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
435590002285	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
435590002286	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
435590002287	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
435590002288	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
435590002289	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
435590002290	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
435590002291	elongation factor G; Reviewed; Region: PRK12739
435590002292	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
435590002293	G1 box; other site
435590002294	putative GEF interaction site [polypeptide binding]; other site
435590002295	GTP/Mg2+ binding site [chemical binding]; other site
435590002296	Switch I region; other site
435590002297	G2 box; other site
435590002298	G3 box; other site
435590002299	Switch II region; other site
435590002300	G4 box; other site
435590002301	G5 box; other site
435590002302	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
435590002303	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
435590002304	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
435590002305	30S ribosomal protein S7; Validated; Region: PRK05302
435590002306	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
435590002307	S17 interaction site [polypeptide binding]; other site
435590002308	S8 interaction site; other site
435590002309	16S rRNA interaction site [nucleotide binding]; other site
435590002310	streptomycin interaction site [chemical binding]; other site
435590002311	23S rRNA interaction site [nucleotide binding]; other site
435590002312	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
435590002313	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
435590002314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590002315	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590002316	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590002317	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
435590002318	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
435590002319	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
435590002320	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
435590002321	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
435590002322	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
435590002323	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
435590002324	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
435590002325	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
435590002326	DNA binding site [nucleotide binding]
435590002327	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
435590002328	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
435590002329	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
435590002330	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
435590002331	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
435590002332	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
435590002333	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
435590002334	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
435590002335	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
435590002336	RPB3 interaction site [polypeptide binding]; other site
435590002337	RPB1 interaction site [polypeptide binding]; other site
435590002338	RPB11 interaction site [polypeptide binding]; other site
435590002339	RPB10 interaction site [polypeptide binding]; other site
435590002340	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
435590002341	core dimer interface [polypeptide binding]; other site
435590002342	peripheral dimer interface [polypeptide binding]; other site
435590002343	L10 interface [polypeptide binding]; other site
435590002344	L11 interface [polypeptide binding]; other site
435590002345	putative EF-Tu interaction site [polypeptide binding]; other site
435590002346	putative EF-G interaction site [polypeptide binding]; other site
435590002347	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
435590002348	23S rRNA interface [nucleotide binding]; other site
435590002349	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
435590002350	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
435590002351	mRNA/rRNA interface [nucleotide binding]; other site
435590002352	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
435590002353	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
435590002354	23S rRNA interface [nucleotide binding]; other site
435590002355	L7/L12 interface [polypeptide binding]; other site
435590002356	putative thiostrepton binding site; other site
435590002357	L25 interface [polypeptide binding]; other site
435590002358	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
435590002359	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
435590002360	putative homodimer interface [polypeptide binding]; other site
435590002361	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
435590002362	heterodimer interface [polypeptide binding]; other site
435590002363	homodimer interface [polypeptide binding]; other site
435590002364	elongation factor Tu; Reviewed; Region: PRK12735
435590002365	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
435590002366	G1 box; other site
435590002367	GEF interaction site [polypeptide binding]; other site
435590002368	GTP/Mg2+ binding site [chemical binding]; other site
435590002369	Switch I region; other site
435590002370	G2 box; other site
435590002371	G3 box; other site
435590002372	Switch II region; other site
435590002373	G4 box; other site
435590002374	G5 box; other site
435590002375	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
435590002376	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
435590002377	Antibiotic Binding Site [chemical binding]; other site
435590002378	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
435590002379	30S subunit binding site; other site
435590002380	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590002381	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590002382	active site
435590002383	DNA binding site [nucleotide binding]
435590002384	Int/Topo IB signature motif; other site
435590002385	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
435590002386	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
435590002387	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
435590002388	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
435590002389	active site
435590002390	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
435590002391	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
435590002392	trimer interface [polypeptide binding]; other site
435590002393	putative metal binding site [ion binding]; other site
435590002394	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590002395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590002396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590002397	Coenzyme A binding pocket [chemical binding]; other site
435590002398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
435590002399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590002400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
435590002401	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590002402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002403	active site
435590002404	phosphorylation site [posttranslational modification]
435590002405	intermolecular recognition site; other site
435590002406	dimerization interface [polypeptide binding]; other site
435590002407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590002408	DNA binding site [nucleotide binding]
435590002409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002411	dimer interface [polypeptide binding]; other site
435590002412	phosphorylation site [posttranslational modification]
435590002413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002414	ATP binding site [chemical binding]; other site
435590002415	Mg2+ binding site [ion binding]; other site
435590002416	G-X-G motif; other site
435590002417	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002418	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590002419	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590002420	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590002421	protein binding site [polypeptide binding]; other site
435590002422	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590002423	Catalytic dyad [active]
435590002424	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
435590002425	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590002426	substrate binding site [chemical binding]; other site
435590002427	ATP binding site [chemical binding]; other site
435590002428	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002429	Two component regulator propeller; Region: Reg_prop; pfam07494
435590002430	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002431	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002433	dimer interface [polypeptide binding]; other site
435590002434	phosphorylation site [posttranslational modification]
435590002435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002436	ATP binding site [chemical binding]; other site
435590002437	Mg2+ binding site [ion binding]; other site
435590002438	G-X-G motif; other site
435590002439	Response regulator receiver domain; Region: Response_reg; pfam00072
435590002440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002441	active site
435590002442	phosphorylation site [posttranslational modification]
435590002443	intermolecular recognition site; other site
435590002444	dimerization interface [polypeptide binding]; other site
435590002445	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002446	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002447	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002448	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002449	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002450	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590002451	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002452	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002453	SusD family; Region: SusD; pfam07980
435590002454	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590002455	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590002456	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590002457	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
435590002458	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
435590002459	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
435590002460	dimerization interface [polypeptide binding]; other site
435590002461	ligand binding site [chemical binding]; other site
435590002462	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
435590002463	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
435590002464	catalytic residue [active]
435590002465	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590002466	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
435590002467	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590002468	peroxiredoxin; Region: AhpC; TIGR03137
435590002469	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
435590002470	dimer interface [polypeptide binding]; other site
435590002471	decamer (pentamer of dimers) interface [polypeptide binding]; other site
435590002472	catalytic triad [active]
435590002473	peroxidatic and resolving cysteines [active]
435590002474	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
435590002475	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
435590002476	Cl binding site [ion binding]; other site
435590002477	oligomer interface [polypeptide binding]; other site
435590002478	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
435590002479	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
435590002480	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
435590002481	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
435590002482	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002483	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590002484	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002485	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
435590002486	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590002487	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590002488	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590002489	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590002490	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
435590002491	active site
435590002492	catalytic tetrad [active]
435590002493	Lyase; Region: Lyase_1; pfam00206
435590002494	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
435590002495	active sites [active]
435590002496	tetramer interface [polypeptide binding]; other site
435590002497	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
435590002498	hydrophobic ligand binding site; other site
435590002499	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002500	active site
435590002501	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590002502	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002503	active site
435590002504	RecX family; Region: RecX; pfam02631
435590002505	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
435590002506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002507	S-adenosylmethionine binding site [chemical binding]; other site
435590002508	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
435590002509	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
435590002510	catalytic motif [active]
435590002511	Zn binding site [ion binding]; other site
435590002512	RibD C-terminal domain; Region: RibD_C; pfam01872
435590002513	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838
435590002514	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
435590002515	catalytic residue [active]
435590002516	putative FPP diphosphate  binding site; other site
435590002517	putative FPP binding hydrophobic cleft; other site
435590002518	dimer interface [polypeptide binding]; other site
435590002519	putative IPP diphosphate binding site; other site
435590002520	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
435590002521	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
435590002522	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
435590002523	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
435590002524	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590002525	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590002526	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
435590002527	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
435590002528	glutamate racemase; Provisional; Region: PRK00865
435590002529	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
435590002530	dimer interface [polypeptide binding]; other site
435590002531	pyridoxal binding site [chemical binding]; other site
435590002532	ATP binding site [chemical binding]; other site
435590002533	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
435590002534	FtsX-like permease family; Region: FtsX; pfam02687
435590002535	Ribosome-binding factor A; Region: RBFA; pfam02033
435590002536	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
435590002537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002538	S-adenosylmethionine binding site [chemical binding]; other site
435590002539	pyruvate kinase; Provisional; Region: PRK05826
435590002540	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
435590002541	domain interfaces; other site
435590002542	active site
435590002543	Dehydroquinase class II; Region: DHquinase_II; pfam01220
435590002544	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
435590002545	trimer interface [polypeptide binding]; other site
435590002546	active site
435590002547	dimer interface [polypeptide binding]; other site
435590002548	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590002549	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
435590002550	active site
435590002551	Int/Topo IB signature motif; other site
435590002552	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002553	binding surface
435590002554	TPR motif; other site
435590002555	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590002556	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590002557	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590002558	catalytic residues [active]
435590002559	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
435590002560	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
435590002561	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
435590002562	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
435590002563	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
435590002564	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
435590002565	active site
435590002566	HIGH motif; other site
435590002567	KMSKS motif; other site
435590002568	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
435590002569	tRNA binding surface [nucleotide binding]; other site
435590002570	anticodon binding site; other site
435590002571	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
435590002572	dimer interface [polypeptide binding]; other site
435590002573	putative tRNA-binding site [nucleotide binding]; other site
435590002574	colanic acid exporter; Provisional; Region: PRK10459
435590002575	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
435590002576	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590002577	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
435590002578	GDP-Fucose binding site [chemical binding]; other site
435590002579	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
435590002580	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
435590002581	active site
435590002582	metal-binding site
435590002583	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
435590002584	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590002585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002586	homodimer interface [polypeptide binding]; other site
435590002587	catalytic residue [active]
435590002588	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
435590002589	LicD family; Region: LicD; pfam04991
435590002590	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590002591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590002592	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590002593	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
435590002594	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590002595	metal-binding site
435590002596	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
435590002597	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
435590002598	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
435590002599	S-ribosylhomocysteinase; Provisional; Region: PRK02260
435590002600	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
435590002601	16S/18S rRNA binding site [nucleotide binding]; other site
435590002602	S13e-L30e interaction site [polypeptide binding]; other site
435590002603	25S rRNA binding site [nucleotide binding]; other site
435590002604	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590002605	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590002606	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590002607	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590002608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590002609	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590002610	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590002611	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590002612	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590002613	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
435590002614	ligand binding site [chemical binding]; other site
435590002615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002616	TPR motif; other site
435590002617	binding surface
435590002618	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590002619	Homeodomain-like domain; Region: HTH_23; cl17451
435590002620	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590002621	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590002622	CHC2 zinc finger; Region: zf-CHC2; cl17510
435590002623	Toprim-like; Region: Toprim_2; pfam13155
435590002624	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
435590002625	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
435590002626	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590002627	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002628	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590002629	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
435590002630	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590002631	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002632	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002633	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
435590002634	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590002635	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590002636	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590002637	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
435590002638	NADH(P)-binding; Region: NAD_binding_10; pfam13460
435590002639	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590002640	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590002641	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590002642	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590002643	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590002644	HTH domain; Region: HTH_11; pfam08279
435590002645	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002647	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
435590002648	FecR protein; Region: FecR; pfam04773
435590002649	Domain of unknown function (DUF3543); Region: DUF3543; pfam12063
435590002650	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002651	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002652	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590002653	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002654	SusD family; Region: SusD; pfam07980
435590002655	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590002656	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590002657	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590002658	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002659	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002660	Peptidase M60-like family; Region: M60-like; pfam13402
435590002661	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590002662	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590002663	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002664	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590002665	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
435590002666	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590002667	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590002668	P-loop; other site
435590002669	Magnesium ion binding site [ion binding]; other site
435590002670	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590002671	Magnesium ion binding site [ion binding]; other site
435590002672	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
435590002673	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002674	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002675	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002676	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590002677	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002678	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002679	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002680	SusD family; Region: SusD; pfam07980
435590002681	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590002682	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
435590002683	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
435590002684	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590002685	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
435590002686	Integrase core domain; Region: rve; pfam00665
435590002687	transposase/IS protein; Provisional; Region: PRK09183
435590002688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590002689	Walker A motif; other site
435590002690	ATP binding site [chemical binding]; other site
435590002691	Walker B motif; other site
435590002692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002694	ATP binding site [chemical binding]; other site
435590002695	Mg2+ binding site [ion binding]; other site
435590002696	G-X-G motif; other site
435590002697	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590002698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002699	active site
435590002700	phosphorylation site [posttranslational modification]
435590002701	intermolecular recognition site; other site
435590002702	dimerization interface [polypeptide binding]; other site
435590002703	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590002704	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
435590002705	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
435590002706	G1 box; other site
435590002707	putative GEF interaction site [polypeptide binding]; other site
435590002708	GTP/Mg2+ binding site [chemical binding]; other site
435590002709	Switch I region; other site
435590002710	G2 box; other site
435590002711	G3 box; other site
435590002712	Switch II region; other site
435590002713	G4 box; other site
435590002714	G5 box; other site
435590002715	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
435590002716	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
435590002717	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
435590002718	putative FMN binding site [chemical binding]; other site
435590002719	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
435590002720	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
435590002721	active site
435590002722	substrate-binding site [chemical binding]; other site
435590002723	metal-binding site [ion binding]
435590002724	ATP binding site [chemical binding]; other site
435590002725	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002726	active site
435590002727	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
435590002728	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
435590002729	TPP-binding site [chemical binding]; other site
435590002730	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
435590002731	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
435590002732	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590002733	dimer interface [polypeptide binding]; other site
435590002734	PYR/PP interface [polypeptide binding]; other site
435590002735	TPP binding site [chemical binding]; other site
435590002736	substrate binding site [chemical binding]; other site
435590002737	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590002738	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590002739	substrate-cofactor binding pocket; other site
435590002740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002741	catalytic residue [active]
435590002742	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590002743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002744	NAD(P) binding site [chemical binding]; other site
435590002745	active site
435590002746	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
435590002747	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
435590002748	active site
435590002749	substrate-binding site [chemical binding]; other site
435590002750	metal-binding site [ion binding]
435590002751	ATP binding site [chemical binding]; other site
435590002752	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002753	active site
435590002754	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
435590002755	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
435590002756	TPP-binding site [chemical binding]; other site
435590002757	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
435590002758	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
435590002759	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590002760	dimer interface [polypeptide binding]; other site
435590002761	PYR/PP interface [polypeptide binding]; other site
435590002762	TPP binding site [chemical binding]; other site
435590002763	substrate binding site [chemical binding]; other site
435590002764	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590002765	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590002766	substrate-cofactor binding pocket; other site
435590002767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002768	catalytic residue [active]
435590002769	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590002770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002771	NAD(P) binding site [chemical binding]; other site
435590002772	active site
435590002773	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590002774	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590002775	substrate binding site [chemical binding]; other site
435590002776	ATP binding site [chemical binding]; other site
435590002777	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
435590002778	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
435590002779	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
435590002780	Protein export membrane protein; Region: SecD_SecF; pfam02355
435590002781	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590002782	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590002783	active site
435590002784	Zn binding site [ion binding]; other site
435590002785	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
435590002786	putative catalytic site [active]
435590002787	putative metal binding site [ion binding]; other site
435590002788	putative phosphate binding site [ion binding]; other site
435590002789	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
435590002790	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
435590002791	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590002792	IHF dimer interface [polypeptide binding]; other site
435590002793	IHF - DNA interface [nucleotide binding]; other site
435590002794	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590002795	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590002796	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590002797	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590002798	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590002799	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590002800	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665
435590002801	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590002802	Ligand Binding Site [chemical binding]; other site
435590002803	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002804	Sulfatase; Region: Sulfatase; pfam00884
435590002805	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
435590002806	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
435590002807	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
435590002808	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
435590002809	substrate binding site [chemical binding]; other site
435590002810	active site
435590002811	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002812	Two component regulator propeller; Region: Reg_prop; pfam07494
435590002813	Two component regulator propeller; Region: Reg_prop; pfam07494
435590002814	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002817	dimer interface [polypeptide binding]; other site
435590002818	phosphorylation site [posttranslational modification]
435590002819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002820	ATP binding site [chemical binding]; other site
435590002821	Mg2+ binding site [ion binding]; other site
435590002822	G-X-G motif; other site
435590002823	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590002824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002825	active site
435590002826	phosphorylation site [posttranslational modification]
435590002827	intermolecular recognition site; other site
435590002828	dimerization interface [polypeptide binding]; other site
435590002829	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002831	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590002832	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002833	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002834	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002835	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590002836	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590002837	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002838	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002839	SusD family; Region: SusD; pfam07980
435590002840	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590002841	active site
435590002842	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
435590002843	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
435590002844	active site
435590002845	HIGH motif; other site
435590002846	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
435590002847	KMSKS motif; other site
435590002848	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
435590002849	tRNA binding surface [nucleotide binding]; other site
435590002850	anticodon binding site; other site
435590002851	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
435590002852	active sites [active]
435590002853	tetramer interface [polypeptide binding]; other site
435590002854	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
435590002855	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
435590002856	NAD(P) binding site [chemical binding]; other site
435590002857	homotetramer interface [polypeptide binding]; other site
435590002858	homodimer interface [polypeptide binding]; other site
435590002859	active site
435590002860	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
435590002861	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002862	dimer interface [polypeptide binding]; other site
435590002863	active site
435590002864	Phosphopantetheine attachment site; Region: PP-binding; cl09936
435590002865	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
435590002866	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
435590002867	putative acyl-acceptor binding pocket; other site
435590002868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002869	S-adenosylmethionine binding site [chemical binding]; other site
435590002870	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590002871	active site 2 [active]
435590002872	active site 1 [active]
435590002873	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590002874	active site
435590002875	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
435590002876	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002877	dimer interface [polypeptide binding]; other site
435590002878	active site
435590002879	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
435590002880	Phosphopantetheine attachment site; Region: PP-binding; cl09936
435590002881	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
435590002882	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002883	dimer interface [polypeptide binding]; other site
435590002884	active site
435590002885	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
435590002886	KilA-N domain; Region: KilA-N; pfam04383
435590002887	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
435590002888	NodB motif; other site
435590002889	active site
435590002890	catalytic site [active]
435590002891	metal binding site [ion binding]; metal-binding site
435590002892	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
435590002893	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
435590002894	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590002895	active site 2 [active]
435590002896	active site 1 [active]
435590002897	Domain of unknown function (DUF4221); Region: DUF4221; pfam13970
435590002898	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590002899	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
435590002900	Ligand binding site; other site
435590002901	Putative Catalytic site; other site
435590002902	DXD motif; other site
435590002903	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
435590002904	Predicted exporter [General function prediction only]; Region: COG4258
435590002905	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
435590002906	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
435590002907	putative acyl-acceptor binding pocket; other site
435590002908	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590002909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002910	S-adenosylmethionine binding site [chemical binding]; other site
435590002911	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
435590002912	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
435590002913	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
435590002914	active site
435590002915	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
435590002916	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
435590002917	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590002918	acyl-activating enzyme (AAE) consensus motif; other site
435590002919	AMP binding site [chemical binding]; other site
435590002920	active site
435590002921	CoA binding site [chemical binding]; other site
435590002922	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
435590002923	GAF domain; Region: GAF; pfam01590
435590002924	PAS fold; Region: PAS_3; pfam08447
435590002925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
435590002926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002927	dimer interface [polypeptide binding]; other site
435590002928	phosphorylation site [posttranslational modification]
435590002929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002930	ATP binding site [chemical binding]; other site
435590002931	Mg2+ binding site [ion binding]; other site
435590002932	G-X-G motif; other site
435590002933	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
435590002934	Bacterial Ig-like domain; Region: Big_5; pfam13205
435590002935	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
435590002936	GH3 auxin-responsive promoter; Region: GH3; pfam03321
435590002937	6-phosphofructokinase; Provisional; Region: PRK03202
435590002938	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
435590002939	active site
435590002940	ADP/pyrophosphate binding site [chemical binding]; other site
435590002941	dimerization interface [polypeptide binding]; other site
435590002942	allosteric effector site; other site
435590002943	fructose-1,6-bisphosphate binding site; other site
435590002944	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002945	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002946	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590002947	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590002948	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002949	SusD family; Region: SusD; pfam07980
435590002950	Sulfatase; Region: Sulfatase; cl17466
435590002951	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002952	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590002953	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590002954	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590002955	Probable galactinol--sucrose galactosyltransferase; Region: PLN02684
435590002956	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002957	Sulfatase; Region: Sulfatase; pfam00884
435590002958	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
435590002959	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
435590002960	dimerization interface [polypeptide binding]; other site
435590002961	active site
435590002962	metal binding site [ion binding]; metal-binding site
435590002963	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
435590002964	dsRNA binding site [nucleotide binding]; other site
435590002965	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
435590002966	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002967	dimer interface [polypeptide binding]; other site
435590002968	active site
435590002969	acyl carrier protein; Provisional; Region: acpP; PRK00982
435590002970	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
435590002971	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
435590002972	active site
435590002973	substrate binding site [chemical binding]; other site
435590002974	cosubstrate binding site; other site
435590002975	catalytic site [active]
435590002976	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002977	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002978	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002979	DNA binding residues [nucleotide binding]
435590002980	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002981	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002982	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590002983	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002984	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590002985	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590002986	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002987	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002989	DNA binding residues [nucleotide binding]
435590002990	FecR protein; Region: FecR; pfam04773
435590002991	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590002992	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590002993	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590002994	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590002995	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
435590002996	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
435590002997	ligand binding site [chemical binding]; other site
435590002998	NAD binding site [chemical binding]; other site
435590002999	catalytic site [active]
435590003000	homodimer interface [polypeptide binding]; other site
435590003001	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
435590003002	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
435590003003	putative active site [active]
435590003004	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
435590003005	putative acyl-acceptor binding pocket; other site
435590003006	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
435590003007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
435590003008	UDP-galactopyranose mutase; Region: GLF; pfam03275
435590003009	Hexokinase; Region: Hexokinase_2; pfam03727
435590003010	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
435590003011	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
435590003012	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
435590003013	Probable Catalytic site; other site
435590003014	active site
435590003015	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
435590003016	Core-2/I-Branching enzyme; Region: Branch; pfam02485
435590003017	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590003018	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590003019	putative ADP-binding pocket [chemical binding]; other site
435590003020	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590003021	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
435590003022	active site
435590003023	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
435590003024	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
435590003025	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
435590003026	Walker A/P-loop; other site
435590003027	ATP binding site [chemical binding]; other site
435590003028	Q-loop/lid; other site
435590003029	ABC transporter signature motif; other site
435590003030	Walker B; other site
435590003031	D-loop; other site
435590003032	H-loop/switch region; other site
435590003033	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
435590003034	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590003035	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590003036	active site
435590003037	Sulfatase; Region: Sulfatase; pfam00884
435590003038	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
435590003039	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
435590003040	Ligand binding site; other site
435590003041	Putative Catalytic site; other site
435590003042	DXD motif; other site
435590003043	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
435590003044	Predicted membrane protein [Function unknown]; Region: COG2246
435590003045	GtrA-like protein; Region: GtrA; pfam04138
435590003046	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
435590003047	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
435590003048	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
435590003049	Sulfatase; Region: Sulfatase; cl17466
435590003050	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
435590003051	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
435590003052	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
435590003053	active site
435590003054	RNA/DNA hybrid binding site [nucleotide binding]; other site
435590003055	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
435590003056	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
435590003057	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003058	active site
435590003059	HIGH motif; other site
435590003060	nucleotide binding site [chemical binding]; other site
435590003061	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
435590003062	KMSK motif region; other site
435590003063	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
435590003064	tRNA binding surface [nucleotide binding]; other site
435590003065	anticodon binding site; other site
435590003066	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003067	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003068	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003069	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003070	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003071	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
435590003072	Peptidase family U32; Region: Peptidase_U32; pfam01136
435590003073	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
435590003074	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
435590003075	FMN binding site [chemical binding]; other site
435590003076	active site
435590003077	catalytic residues [active]
435590003078	substrate binding site [chemical binding]; other site
435590003079	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
435590003080	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
435590003081	active site
435590003082	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590003083	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003084	NAD(P) binding site [chemical binding]; other site
435590003085	active site
435590003086	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
435590003087	Cation efflux family; Region: Cation_efflux; pfam01545
435590003088	ribonuclease R; Region: RNase_R; TIGR02063
435590003089	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590003090	RNB domain; Region: RNB; pfam00773
435590003091	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
435590003092	RNA binding site [nucleotide binding]; other site
435590003093	serine O-acetyltransferase; Region: cysE; TIGR01172
435590003094	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
435590003095	trimer interface [polypeptide binding]; other site
435590003096	active site
435590003097	substrate binding site [chemical binding]; other site
435590003098	CoA binding site [chemical binding]; other site
435590003099	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
435590003100	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
435590003101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
435590003102	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590003103	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590003104	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
435590003105	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
435590003106	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
435590003107	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
435590003108	Predicted membrane protein [Function unknown]; Region: COG1238
435590003109	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
435590003110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
435590003111	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
435590003112	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
435590003113	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
435590003114	putative metal binding residues [ion binding]; other site
435590003115	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
435590003116	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
435590003117	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
435590003118	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
435590003119	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
435590003120	NodB motif; other site
435590003121	putative active site [active]
435590003122	putative catalytic site [active]
435590003123	putative Zn binding site [ion binding]; other site
435590003124	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
435590003125	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
435590003126	NADP binding site [chemical binding]; other site
435590003127	homodimer interface [polypeptide binding]; other site
435590003128	active site
435590003129	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
435590003130	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
435590003131	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
435590003132	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590003133	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
435590003134	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
435590003135	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
435590003136	ORF6N domain; Region: ORF6N; pfam10543
435590003137	L-aspartate oxidase; Provisional; Region: PRK09077
435590003138	L-aspartate oxidase; Provisional; Region: PRK06175
435590003139	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
435590003140	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003141	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003142	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
435590003143	Pectic acid lyase; Region: Pec_lyase; pfam09492
435590003144	putative pectinesterase; Region: PLN02432; cl01911
435590003145	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590003146	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003147	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003148	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003149	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003150	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003151	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590003152	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590003153	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
435590003154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003155	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003156	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590003157	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
435590003158	putative substrate binding site [chemical binding]; other site
435590003159	active site
435590003160	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590003161	sugar binding site [chemical binding]; other site
435590003162	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
435590003163	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590003164	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590003165	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590003166	SusD family; Region: SusD; pfam07980
435590003167	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003168	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003169	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003171	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003172	multiple promoter invertase; Provisional; Region: mpi; PRK13413
435590003173	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
435590003174	catalytic residues [active]
435590003175	catalytic nucleophile [active]
435590003176	Presynaptic Site I dimer interface [polypeptide binding]; other site
435590003177	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
435590003178	Synaptic Flat tetramer interface [polypeptide binding]; other site
435590003179	Synaptic Site I dimer interface [polypeptide binding]; other site
435590003180	DNA binding site [nucleotide binding]
435590003181	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
435590003182	DNA-binding interface [nucleotide binding]; DNA binding site
435590003183	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003184	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003185	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003186	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003187	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003188	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590003189	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003190	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
435590003191	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003193	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003194	Two component regulator propeller; Region: Reg_prop; pfam07494
435590003195	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003196	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590003198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003199	dimer interface [polypeptide binding]; other site
435590003200	phosphorylation site [posttranslational modification]
435590003201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003202	ATP binding site [chemical binding]; other site
435590003203	Mg2+ binding site [ion binding]; other site
435590003204	G-X-G motif; other site
435590003205	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590003206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003207	active site
435590003208	phosphorylation site [posttranslational modification]
435590003209	intermolecular recognition site; other site
435590003210	dimerization interface [polypeptide binding]; other site
435590003211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590003212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003213	Rubrerythrin [Energy production and conversion]; Region: COG1592
435590003214	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
435590003215	binuclear metal center [ion binding]; other site
435590003216	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
435590003217	iron binding site [ion binding]; other site
435590003218	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
435590003219	putative transporter; Provisional; Region: PRK11660
435590003220	Sulfate transporter family; Region: Sulfate_transp; pfam00916
435590003221	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
435590003222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003223	FeS/SAM binding site; other site
435590003224	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
435590003225	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590003226	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
435590003227	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
435590003228	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590003229	quinolinate synthetase; Provisional; Region: PRK09375
435590003230	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
435590003231	active site
435590003232	dimerization interface [polypeptide binding]; other site
435590003233	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590003234	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
435590003235	Uncharacterized conserved protein [Function unknown]; Region: COG1284
435590003236	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590003237	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590003238	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
435590003239	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
435590003240	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003241	active site
435590003242	HIGH motif; other site
435590003243	nucleotide binding site [chemical binding]; other site
435590003244	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003245	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
435590003246	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003247	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003248	active site
435590003249	KMSKS motif; other site
435590003250	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
435590003251	tRNA binding surface [nucleotide binding]; other site
435590003252	Two component regulator propeller; Region: Reg_prop; pfam07494
435590003253	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003254	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590003256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003257	dimer interface [polypeptide binding]; other site
435590003258	phosphorylation site [posttranslational modification]
435590003259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003260	ATP binding site [chemical binding]; other site
435590003261	Mg2+ binding site [ion binding]; other site
435590003262	G-X-G motif; other site
435590003263	Response regulator receiver domain; Region: Response_reg; pfam00072
435590003264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003265	active site
435590003266	phosphorylation site [posttranslational modification]
435590003267	intermolecular recognition site; other site
435590003268	dimerization interface [polypeptide binding]; other site
435590003269	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590003270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003271	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590003272	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590003273	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590003274	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590003275	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003276	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003277	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003278	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003279	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590003280	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003281	SusD family; Region: SusD; pfam07980
435590003282	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590003283	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003284	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003285	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003286	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590003287	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003288	protein binding site [polypeptide binding]; other site
435590003289	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590003290	Domain interface; other site
435590003291	Peptide binding site; other site
435590003292	Active site tetrad [active]
435590003293	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590003294	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590003295	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
435590003296	dimerization interface [polypeptide binding]; other site
435590003297	DNA binding residues [nucleotide binding]
435590003298	FecR protein; Region: FecR; pfam04773
435590003299	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590003300	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003301	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003302	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003303	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003304	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590003305	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590003306	SusD family; Region: SusD; pfam07980
435590003307	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003308	Sulfatase; Region: Sulfatase; pfam00884
435590003309	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003310	Sulfatase; Region: Sulfatase; pfam00884
435590003311	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590003312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590003313	Walker A/P-loop; other site
435590003314	ATP binding site [chemical binding]; other site
435590003315	ABC transporter signature motif; other site
435590003316	Walker B; other site
435590003317	D-loop; other site
435590003318	H-loop/switch region; other site
435590003319	ABC transporter; Region: ABC_tran_2; pfam12848
435590003320	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590003321	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
435590003322	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
435590003323	PA14 domain; Region: PA14; cl08459
435590003324	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
435590003325	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
435590003326	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
435590003327	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
435590003328	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
435590003329	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590003330	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003331	FeS/SAM binding site; other site
435590003332	TRAM domain; Region: TRAM; pfam01938
435590003333	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
435590003334	PspC domain; Region: PspC; pfam04024
435590003335	Methyltransferase domain; Region: Methyltransf_23; pfam13489
435590003336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590003337	S-adenosylmethionine binding site [chemical binding]; other site
435590003338	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
435590003339	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
435590003340	Bacitracin resistance protein BacA; Region: BacA; pfam02673
435590003341	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
435590003342	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
435590003343	RNA binding site [nucleotide binding]; other site
435590003344	active site
435590003345	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
435590003346	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
435590003347	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
435590003348	catalytic center binding site [active]
435590003349	ATP binding site [chemical binding]; other site
435590003350	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590003351	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590003352	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
435590003353	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590003354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590003355	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590003356	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590003357	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003358	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590003359	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
435590003360	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590003361	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590003362	putative catalytic site [active]
435590003363	putative metal binding site [ion binding]; other site
435590003364	putative catalytic site [active]
435590003365	putative phosphate binding site [ion binding]; other site
435590003366	putative phosphate binding site [ion binding]; other site
435590003367	putative metal binding site [ion binding]; other site
435590003368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003369	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590003370	putative substrate translocation pore; other site
435590003371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003372	S-adenosylmethionine synthetase; Validated; Region: PRK05250
435590003373	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
435590003374	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
435590003375	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
435590003376	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590003377	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
435590003378	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
435590003379	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
435590003380	active site
435590003381	ribonuclease P; Reviewed; Region: rnpA; PRK01903
435590003382	Haemolytic domain; Region: Haemolytic; pfam01809
435590003383	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590003384	active site
435590003385	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
435590003386	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
435590003387	active site
435590003388	HIGH motif; other site
435590003389	dimer interface [polypeptide binding]; other site
435590003390	KMSKS motif; other site
435590003391	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590003392	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003393	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003394	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003395	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590003396	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003397	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003398	protein binding site [polypeptide binding]; other site
435590003399	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590003400	Domain interface; other site
435590003401	Peptide binding site; other site
435590003402	Active site tetrad [active]
435590003403	Flavin Reductases; Region: FlaRed; cl00801
435590003404	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
435590003405	MutS domain I; Region: MutS_I; pfam01624
435590003406	MutS domain II; Region: MutS_II; pfam05188
435590003407	MutS domain III; Region: MutS_III; pfam05192
435590003408	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
435590003409	Walker A/P-loop; other site
435590003410	ATP binding site [chemical binding]; other site
435590003411	Q-loop/lid; other site
435590003412	ABC transporter signature motif; other site
435590003413	Walker B; other site
435590003414	D-loop; other site
435590003415	H-loop/switch region; other site
435590003416	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590003417	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
435590003418	active site
435590003419	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
435590003420	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590003421	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003423	binding surface
435590003424	TPR motif; other site
435590003425	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003426	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003427	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003428	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003430	binding surface
435590003431	TPR motif; other site
435590003432	TPR repeat; Region: TPR_11; pfam13414
435590003433	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590003434	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
435590003435	Chloramphenicol acetyltransferase; Region: CAT; smart01059
435590003436	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
435590003437	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
435590003438	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
435590003439	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
435590003440	GTP-binding protein YchF; Reviewed; Region: PRK09601
435590003441	YchF GTPase; Region: YchF; cd01900
435590003442	G1 box; other site
435590003443	GTP/Mg2+ binding site [chemical binding]; other site
435590003444	Switch I region; other site
435590003445	G2 box; other site
435590003446	Switch II region; other site
435590003447	G3 box; other site
435590003448	G4 box; other site
435590003449	G5 box; other site
435590003450	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
435590003451	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590003452	DNA polymerase I; Region: pola; TIGR00593
435590003453	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
435590003454	active site
435590003455	metal binding site 1 [ion binding]; metal-binding site
435590003456	putative 5' ssDNA interaction site; other site
435590003457	metal binding site 3; metal-binding site
435590003458	metal binding site 2 [ion binding]; metal-binding site
435590003459	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
435590003460	putative DNA binding site [nucleotide binding]; other site
435590003461	putative metal binding site [ion binding]; other site
435590003462	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
435590003463	active site
435590003464	catalytic site [active]
435590003465	substrate binding site [chemical binding]; other site
435590003466	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
435590003467	active site
435590003468	DNA binding site [nucleotide binding]
435590003469	catalytic site [active]
435590003470	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
435590003471	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
435590003472	substrate binding pocket [chemical binding]; other site
435590003473	chain length determination region; other site
435590003474	substrate-Mg2+ binding site; other site
435590003475	catalytic residues [active]
435590003476	aspartate-rich region 1; other site
435590003477	active site lid residues [active]
435590003478	aspartate-rich region 2; other site
435590003479	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
435590003480	intersubunit interface [polypeptide binding]; other site
435590003481	active site
435590003482	catalytic residue [active]
435590003483	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
435590003484	homodimer interface [polypeptide binding]; other site
435590003485	metal binding site [ion binding]; metal-binding site
435590003486	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
435590003487	putative active site [active]
435590003488	dimerization interface [polypeptide binding]; other site
435590003489	putative tRNAtyr binding site [nucleotide binding]; other site
435590003490	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
435590003491	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
435590003492	GIY-YIG motif/motif A; other site
435590003493	active site
435590003494	catalytic site [active]
435590003495	putative DNA binding site [nucleotide binding]; other site
435590003496	metal binding site [ion binding]; metal-binding site
435590003497	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cd00758
435590003498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590003499	active site
435590003500	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
435590003501	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
435590003502	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
435590003503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
435590003504	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
435590003505	probable rRNA maturation factor YbeY; Region: TIGR00043
435590003506	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
435590003507	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
435590003508	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
435590003509	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
435590003510	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
435590003511	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590003512	active site
435590003513	DNA binding site [nucleotide binding]
435590003514	Int/Topo IB signature motif; other site
435590003515	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003516	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590003517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590003518	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590003519	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003520	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590003521	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
435590003522	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003523	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003524	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
435590003525	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590003526	active site
435590003527	metal binding site [ion binding]; metal-binding site
435590003528	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
435590003529	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
435590003530	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
435590003531	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
435590003532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003533	ATP binding site [chemical binding]; other site
435590003534	Mg2+ binding site [ion binding]; other site
435590003535	G-X-G motif; other site
435590003536	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
435590003537	ATP binding site [chemical binding]; other site
435590003538	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
435590003539	active site
435590003540	putative metal-binding site [ion binding]; other site
435590003541	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
435590003542	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
435590003543	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
435590003544	active site
435590003545	(T/H)XGH motif; other site
435590003546	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003547	C-terminal peptidase (prc); Region: prc; TIGR00225
435590003548	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003549	protein binding site [polypeptide binding]; other site
435590003550	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590003551	Catalytic dyad [active]
435590003552	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
435590003553	active site
435590003554	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
435590003555	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
435590003556	putative Iron-sulfur protein interface [polypeptide binding]; other site
435590003557	proximal heme binding site [chemical binding]; other site
435590003558	distal heme binding site [chemical binding]; other site
435590003559	putative dimer interface [polypeptide binding]; other site
435590003560	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
435590003561	L-aspartate oxidase; Provisional; Region: PRK06175
435590003562	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
435590003563	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
435590003564	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
435590003565	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003566	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590003567	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590003568	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590003569	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590003570	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590003571	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590003572	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590003573	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
435590003574	DNA protecting protein DprA; Region: dprA; TIGR00732
435590003575	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590003576	active site
435590003577	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
435590003578	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
435590003579	FMN binding site [chemical binding]; other site
435590003580	active site
435590003581	catalytic residues [active]
435590003582	substrate binding site [chemical binding]; other site
435590003583	Virulence-associated protein E; Region: VirE; pfam05272
435590003584	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003585	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
435590003586	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
435590003587	dimer interface [polypeptide binding]; other site
435590003588	active site
435590003589	metal binding site [ion binding]; metal-binding site
435590003590	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
435590003591	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003592	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003593	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003594	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003595	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
435590003596	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003597	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
435590003598	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590003599	putative active site [active]
435590003600	putative metal binding site [ion binding]; other site
435590003601	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
435590003602	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
435590003603	dihydrodipicolinate reductase; Provisional; Region: PRK00048
435590003604	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
435590003605	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
435590003606	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
435590003607	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
435590003608	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
435590003609	Catalytic site [active]
435590003610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590003611	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590003612	Catalytic site [active]
435590003613	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
435590003614	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590003615	WbqC-like protein family; Region: WbqC; pfam08889
435590003616	D-mannonate oxidoreductase; Provisional; Region: PRK08277
435590003617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003618	NAD(P) binding site [chemical binding]; other site
435590003619	active site
435590003620	mannonate dehydratase; Provisional; Region: PRK03906
435590003621	mannonate dehydratase; Region: uxuA; TIGR00695
435590003622	Transposase domain (DUF772); Region: DUF772; pfam05598
435590003623	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590003624	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003625	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003626	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003627	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590003628	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003629	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590003630	SusD family; Region: SusD; pfam07980
435590003631	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003632	Sulfatase; Region: Sulfatase; cl17466
435590003633	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590003635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003636	dimer interface [polypeptide binding]; other site
435590003637	phosphorylation site [posttranslational modification]
435590003638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003639	ATP binding site [chemical binding]; other site
435590003640	Mg2+ binding site [ion binding]; other site
435590003641	G-X-G motif; other site
435590003642	Response regulator receiver domain; Region: Response_reg; pfam00072
435590003643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003644	active site
435590003645	phosphorylation site [posttranslational modification]
435590003646	intermolecular recognition site; other site
435590003647	dimerization interface [polypeptide binding]; other site
435590003648	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003649	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003650	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
435590003651	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590003652	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590003653	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590003654	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590003655	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
435590003656	putative active site [active]
435590003657	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
435590003658	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590003659	putative substrate binding site [chemical binding]; other site
435590003660	putative ATP binding site [chemical binding]; other site
435590003661	Glyco_18 domain; Region: Glyco_18; smart00636
435590003662	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
435590003663	active site
435590003664	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
435590003665	Peptidase family M1; Region: Peptidase_M1; pfam01433
435590003666	Zn binding site [ion binding]; other site
435590003667	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: PRK14664
435590003668	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590003669	Ligand Binding Site [chemical binding]; other site
435590003670	Flavodoxin domain; Region: Flavodoxin_5; cl17428
435590003671	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
435590003672	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590003673	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590003674	Clostripain family; Region: Peptidase_C11; pfam03415
435590003675	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003676	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003677	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590003678	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590003679	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
435590003680	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590003681	Virulence-associated protein E; Region: VirE; pfam05272
435590003682	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003683	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590003684	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590003685	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590003686	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003688	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590003689	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590003690	active site
435590003691	DNA binding site [nucleotide binding]
435590003692	Int/Topo IB signature motif; other site
435590003693	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
435590003694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590003695	Walker A motif; other site
435590003696	ATP binding site [chemical binding]; other site
435590003697	Walker B motif; other site
435590003698	arginine finger; other site
435590003699	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
435590003700	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590003701	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590003702	Domain of unknown function (DUF389); Region: DUF389; pfam04087
435590003703	Peptidase S46; Region: Peptidase_S46; pfam10459
435590003704	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590003705	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
435590003706	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590003707	ATP binding site [chemical binding]; other site
435590003708	Mg++ binding site [ion binding]; other site
435590003709	motif III; other site
435590003710	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590003711	nucleotide binding region [chemical binding]; other site
435590003712	ATP-binding site [chemical binding]; other site
435590003713	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
435590003714	RNA binding site [nucleotide binding]; other site
435590003715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590003716	salt bridge; other site
435590003717	non-specific DNA binding site [nucleotide binding]; other site
435590003718	sequence-specific DNA binding site [nucleotide binding]; other site
435590003719	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
435590003720	CAAX protease self-immunity; Region: Abi; pfam02517
435590003721	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590003722	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
435590003723	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
435590003724	active site
435590003725	Riboflavin kinase; Region: Flavokinase; pfam01687
435590003726	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
435590003727	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
435590003728	plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517
435590003729	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
435590003730	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590003731	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
435590003732	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590003733	motif II; other site
435590003734	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
435590003735	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590003736	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590003737	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
435590003738	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590003739	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590003740	catalytic residues [active]
435590003741	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
435590003742	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
435590003743	putative DNA binding site [nucleotide binding]; other site
435590003744	putative Zn2+ binding site [ion binding]; other site
435590003745	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
435590003746	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
435590003747	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590003748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003749	active site
435590003750	phosphorylation site [posttranslational modification]
435590003751	intermolecular recognition site; other site
435590003752	dimerization interface [polypeptide binding]; other site
435590003753	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590003754	DNA binding site [nucleotide binding]
435590003755	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590003756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003757	dimer interface [polypeptide binding]; other site
435590003758	phosphorylation site [posttranslational modification]
435590003759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003760	ATP binding site [chemical binding]; other site
435590003761	Mg2+ binding site [ion binding]; other site
435590003762	G-X-G motif; other site
435590003763	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590003764	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590003765	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
435590003766	M28 Zn-Peptidases; Region: M28_like_6; cd08656
435590003767	Peptidase family M28; Region: Peptidase_M28; pfam04389
435590003768	metal binding site [ion binding]; metal-binding site
435590003769	Peptidase C26; Region: Peptidase_C26; pfam07722
435590003770	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
435590003771	catalytic triad [active]
435590003772	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
435590003773	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
435590003774	active site
435590003775	dimer interface [polypeptide binding]; other site
435590003776	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
435590003777	butyrate kinase; Provisional; Region: PRK03011
435590003778	Virulence-associated protein E; Region: VirE; pfam05272
435590003779	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003780	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590003781	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003782	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590003783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590003784	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
435590003785	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
435590003786	putative DNA binding site [nucleotide binding]; other site
435590003787	putative Zn2+ binding site [ion binding]; other site
435590003788	AsnC family; Region: AsnC_trans_reg; pfam01037
435590003789	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
435590003790	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590003791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590003792	Transporter associated domain; Region: CorC_HlyC; smart01091
435590003793	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
435590003794	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
435590003795	nudix motif; other site
435590003796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003797	binding surface
435590003798	TPR motif; other site
435590003799	TPR repeat; Region: TPR_11; pfam13414
435590003800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003801	binding surface
435590003802	TPR motif; other site
435590003803	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590003804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003805	binding surface
435590003806	TPR motif; other site
435590003807	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590003808	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003809	DNA topoisomerase I; Provisional; Region: PRK08780
435590003810	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
435590003811	active site
435590003812	interdomain interaction site; other site
435590003813	putative metal-binding site [ion binding]; other site
435590003814	nucleotide binding site [chemical binding]; other site
435590003815	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590003816	domain I; other site
435590003817	DNA binding groove [nucleotide binding]
435590003818	phosphate binding site [ion binding]; other site
435590003819	domain II; other site
435590003820	domain III; other site
435590003821	nucleotide binding site [chemical binding]; other site
435590003822	catalytic site [active]
435590003823	domain IV; other site
435590003824	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003825	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003826	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003827	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
435590003828	Shikimate kinase; Region: SKI; pfam01202
435590003829	ADP binding site [chemical binding]; other site
435590003830	magnesium binding site [ion binding]; other site
435590003831	putative shikimate binding site; other site
435590003832	arginine decarboxylase; Provisional; Region: PRK05354
435590003833	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
435590003834	dimer interface [polypeptide binding]; other site
435590003835	active site
435590003836	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590003837	catalytic residues [active]
435590003838	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
435590003839	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
435590003840	nucleotide binding site [chemical binding]; other site
435590003841	N-acetyl-L-glutamate binding site [chemical binding]; other site
435590003842	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
435590003843	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590003844	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590003845	DNA binding residues [nucleotide binding]
435590003846	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
435590003847	Protein of unknown function DUF45; Region: DUF45; pfam01863
435590003848	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
435590003849	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
435590003850	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590003851	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003852	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
435590003853	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003854	FeS/SAM binding site; other site
435590003855	MFS transport protein AraJ; Provisional; Region: PRK10091
435590003856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003857	putative substrate translocation pore; other site
435590003858	hypothetical protein; Validated; Region: PRK02001
435590003859	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
435590003860	heptamer interface [polypeptide binding]; other site
435590003861	Sm1 motif; other site
435590003862	hexamer interface [polypeptide binding]; other site
435590003863	RNA binding site [nucleotide binding]; other site
435590003864	Sm2 motif; other site
435590003865	transcription termination factor NusA; Region: NusA; TIGR01953
435590003866	NusA N-terminal domain; Region: NusA_N; pfam08529
435590003867	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
435590003868	RNA binding site [nucleotide binding]; other site
435590003869	homodimer interface [polypeptide binding]; other site
435590003870	NusA-like KH domain; Region: KH_5; pfam13184
435590003871	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
435590003872	G-X-X-G motif; other site
435590003873	translation initiation factor IF-2; Region: IF-2; TIGR00487
435590003874	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
435590003875	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
435590003876	G1 box; other site
435590003877	putative GEF interaction site [polypeptide binding]; other site
435590003878	GTP/Mg2+ binding site [chemical binding]; other site
435590003879	Switch I region; other site
435590003880	G2 box; other site
435590003881	G3 box; other site
435590003882	Switch II region; other site
435590003883	G4 box; other site
435590003884	G5 box; other site
435590003885	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
435590003886	Translation-initiation factor 2; Region: IF-2; pfam11987
435590003887	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
435590003888	Colicin V production protein; Region: Colicin_V; pfam02674
435590003889	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
435590003890	putative ABC transporter; Region: ycf24; CHL00085
435590003891	FeS assembly ATPase SufC; Region: sufC; TIGR01978
435590003892	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
435590003893	Walker A/P-loop; other site
435590003894	ATP binding site [chemical binding]; other site
435590003895	Q-loop/lid; other site
435590003896	ABC transporter signature motif; other site
435590003897	Walker B; other site
435590003898	D-loop; other site
435590003899	H-loop/switch region; other site
435590003900	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
435590003901	FeS assembly protein SufD; Region: sufD; TIGR01981
435590003902	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
435590003903	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
435590003904	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
435590003905	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590003906	catalytic residue [active]
435590003907	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590003908	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590003909	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590003910	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590003911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590003912	Coenzyme A binding pocket [chemical binding]; other site
435590003913	alpha-glucosidase; Provisional; Region: PRK10137
435590003914	Trehalase; Region: Trehalase; cl17346
435590003915	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590003916	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590003917	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590003918	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590003919	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590003920	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
435590003921	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590003922	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003923	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003924	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003925	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003926	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003927	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003928	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003929	binding surface
435590003930	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003931	TPR motif; other site
435590003932	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003933	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
435590003934	RNA/DNA hybrid binding site [nucleotide binding]; other site
435590003935	active site
435590003936	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590003937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003938	putative substrate translocation pore; other site
435590003939	L-fucose isomerase; Provisional; Region: fucI; PRK10991
435590003940	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
435590003941	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590003942	trimer interface [polypeptide binding]; other site
435590003943	substrate binding site [chemical binding]; other site
435590003944	Mn binding site [ion binding]; other site
435590003945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
435590003946	DNA-binding site [nucleotide binding]; DNA binding site
435590003947	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
435590003948	putative dimerization interface [polypeptide binding]; other site
435590003949	putative ligand binding site [chemical binding]; other site
435590003950	Transcriptional regulators [Transcription]; Region: PurR; COG1609
435590003951	phosphoglyceromutase; Provisional; Region: PRK05434
435590003952	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
435590003953	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
435590003954	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590003955	SusE outer membrane protein; Region: SusE; pfam14292
435590003956	Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967
435590003957	starch binding site [chemical binding]; other site
435590003958	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
435590003959	starch binding site [chemical binding]; other site
435590003960	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003961	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003962	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590003963	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590003964	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590003965	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590003966	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
435590003967	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
435590003968	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
435590003969	Ca binding site [ion binding]; other site
435590003970	active site
435590003971	homodimer interface [polypeptide binding]; other site
435590003972	catalytic site [active]
435590003973	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
435590003974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
435590003975	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590003976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590003978	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
435590003979	4-alpha-glucanotransferase; Region: PLN02950
435590003980	starch-binding site 2 [chemical binding]; other site
435590003981	starch-binding site 1 [chemical binding]; other site
435590003982	Disproportionating enzyme 2 (DPE2), N-terminal CBM20 (carbohydrate-binding module, family 20) domain, repeat 2. DPE2 is a transglucosidase that is essential for the cytosolic metabolism of maltose in plant leaves at night. Maltose is an intermediate on...; Region: CBM20_DPE2_repeat2; cd05816
435590003983	starch binding site 2 [chemical binding]; other site
435590003984	starch binding site 1 [chemical binding]; other site
435590003985	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
435590003986	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
435590003987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003988	ATP binding site [chemical binding]; other site
435590003989	Mg2+ binding site [ion binding]; other site
435590003990	G-X-G motif; other site
435590003991	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
435590003992	anchoring element; other site
435590003993	dimer interface [polypeptide binding]; other site
435590003994	ATP binding site [chemical binding]; other site
435590003995	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
435590003996	active site
435590003997	putative metal-binding site [ion binding]; other site
435590003998	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
435590003999	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
435590004000	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
435590004001	Recombination protein O N terminal; Region: RecO_N; pfam11967
435590004002	Recombination protein O C terminal; Region: RecO_C; pfam02565
435590004003	Yqey-like protein; Region: YqeY; pfam09424
435590004004	cell division protein FtsZ; Validated; Region: PRK09330
435590004005	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
435590004006	nucleotide binding site [chemical binding]; other site
435590004007	SulA interaction site; other site
435590004008	cell division protein FtsA; Region: ftsA; TIGR01174
435590004009	Cell division protein FtsA; Region: FtsA; smart00842
435590004010	Cell division protein FtsA; Region: FtsA; pfam14450
435590004011	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
435590004012	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
435590004013	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590004014	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590004015	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590004016	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
435590004017	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
435590004018	homodimer interface [polypeptide binding]; other site
435590004019	active site
435590004020	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
435590004021	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
435590004022	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590004023	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590004024	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
435590004025	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
435590004026	Mg++ binding site [ion binding]; other site
435590004027	putative catalytic motif [active]
435590004028	putative substrate binding site [chemical binding]; other site
435590004029	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
435590004030	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590004031	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590004032	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590004033	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
435590004034	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
435590004035	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
435590004036	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
435590004037	MraW methylase family; Region: Methyltransf_5; cl17771
435590004038	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
435590004039	mraZ protein; Region: TIGR00242
435590004040	MraZ protein; Region: MraZ; pfam02381
435590004041	MraZ protein; Region: MraZ; pfam02381
435590004042	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
435590004043	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
435590004044	putative acyl-acceptor binding pocket; other site
435590004045	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
435590004046	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
435590004047	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
435590004048	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
435590004049	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
435590004050	trimer interface [polypeptide binding]; other site
435590004051	active site
435590004052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004053	binding surface
435590004054	TPR motif; other site
435590004055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004056	binding surface
435590004057	TPR motif; other site
435590004058	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004059	TPR motif; other site
435590004060	binding surface
435590004061	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004062	binding surface
435590004063	TPR motif; other site
435590004064	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
435590004065	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
435590004066	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590004067	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590004068	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
435590004069	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
435590004070	glutaminase A; Region: Gln_ase; TIGR03814
435590004071	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
435590004072	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
435590004073	AIR carboxylase; Region: AIRC; pfam00731
435590004074	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
435590004075	lipoyl attachment site [posttranslational modification]; other site
435590004076	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
435590004077	active site
435590004078	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
435590004079	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
435590004080	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
435590004081	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
435590004082	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
435590004083	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590004084	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
435590004085	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
435590004086	dimer interface [polypeptide binding]; other site
435590004087	active site
435590004088	glycine loop; other site
435590004089	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
435590004090	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
435590004091	active site
435590004092	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
435590004093	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590004094	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590004095	PhoU domain; Region: PhoU; pfam01895
435590004096	PhoU domain; Region: PhoU; pfam01895
435590004097	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590004098	Transposase domain (DUF772); Region: DUF772; pfam05598
435590004099	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590004100	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
435590004101	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
435590004102	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
435590004103	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
435590004104	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
435590004105	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
435590004106	NAD-dependent deacetylase; Provisional; Region: PRK00481
435590004107	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
435590004108	NAD+ binding site [chemical binding]; other site
435590004109	substrate binding site [chemical binding]; other site
435590004110	Zn binding site [ion binding]; other site
435590004111	Rubredoxin [Energy production and conversion]; Region: COG1773
435590004112	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
435590004113	iron binding site [ion binding]; other site
435590004114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590004115	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004116	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590004117	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
435590004118	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
435590004119	RNase E interface [polypeptide binding]; other site
435590004120	trimer interface [polypeptide binding]; other site
435590004121	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
435590004122	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
435590004123	RNase E interface [polypeptide binding]; other site
435590004124	trimer interface [polypeptide binding]; other site
435590004125	active site
435590004126	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
435590004127	RNA binding site [nucleotide binding]; other site
435590004128	domain interface; other site
435590004129	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590004130	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590004131	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590004132	catalytic residues [active]
435590004133	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
435590004134	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
435590004135	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
435590004136	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
435590004137	nucleotide binding site/active site [active]
435590004138	HIT family signature motif; other site
435590004139	catalytic residue [active]
435590004140	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590004141	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590004142	Substrate binding site; other site
435590004143	Abi-like protein; Region: Abi_2; pfam07751
435590004144	CHC2 zinc finger; Region: zf-CHC2; cl17510
435590004145	Toprim-like; Region: Toprim_2; pfam13155
435590004146	active site
435590004147	metal binding site [ion binding]; metal-binding site
435590004148	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590004149	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
435590004150	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590004151	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590004152	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004153	active site
435590004154	DNA binding site [nucleotide binding]
435590004155	Int/Topo IB signature motif; other site
435590004156	Fic/DOC family; Region: Fic; pfam02661
435590004157	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590004159	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590004160	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590004161	DNA binding residues [nucleotide binding]
435590004162	dimerization interface [polypeptide binding]; other site
435590004163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590004164	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004165	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590004166	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590004167	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004168	B12 binding domain; Region: B12-binding; pfam02310
435590004169	B12 binding site [chemical binding]; other site
435590004170	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
435590004171	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
435590004172	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
435590004173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
435590004174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590004175	Coenzyme A binding pocket [chemical binding]; other site
435590004176	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
435590004177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590004178	Coenzyme A binding pocket [chemical binding]; other site
435590004179	Protein of unknown function, DUF488; Region: DUF488; cl01246
435590004180	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
435590004181	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590004182	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
435590004183	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
435590004184	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590004185	carboxyltransferase (CT) interaction site; other site
435590004186	biotinylation site [posttranslational modification]; other site
435590004187	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590004188	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
435590004189	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
435590004190	PS-10 peptidase S37; Region: Peptidase_S37; pfam05576
435590004191	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
435590004192	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
435590004193	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590004194	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590004195	primosomal protein N' Region: priA; TIGR00595
435590004196	ATP binding site [chemical binding]; other site
435590004197	putative Mg++ binding site [ion binding]; other site
435590004198	helicase superfamily c-terminal domain; Region: HELICc; smart00490
435590004199	ATP-binding site [chemical binding]; other site
435590004200	putative hydrolase; Validated; Region: PRK09248
435590004201	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
435590004202	active site
435590004203	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
435590004204	Low molecular weight phosphatase family; Region: LMWPc; cd00115
435590004205	active site
435590004206	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
435590004207	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
435590004208	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590004209	Zn2+ binding site [ion binding]; other site
435590004210	Mg2+ binding site [ion binding]; other site
435590004211	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
435590004212	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
435590004213	HIGH motif; other site
435590004214	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
435590004215	active site
435590004216	KMSKS motif; other site
435590004217	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
435590004218	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
435590004219	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590004220	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590004221	nudix motif; other site
435590004222	Cupin domain; Region: Cupin_2; cl17218
435590004223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004224	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
435590004225	NAD(P) binding site [chemical binding]; other site
435590004226	active site
435590004227	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590004228	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
435590004229	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
435590004230	metal binding site [ion binding]; metal-binding site
435590004231	dimer interface [polypeptide binding]; other site
435590004232	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590004233	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590004234	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
435590004235	acyl-activating enzyme (AAE) consensus motif; other site
435590004236	putative AMP binding site [chemical binding]; other site
435590004237	putative active site [active]
435590004238	putative CoA binding site [chemical binding]; other site
435590004239	peptide chain release factor 2; Validated; Region: prfB; PRK00578
435590004240	This domain is found in peptide chain release factors; Region: PCRF; smart00937
435590004241	RF-1 domain; Region: RF-1; pfam00472
435590004242	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
435590004243	putative active site [active]
435590004244	putative metal binding residues [ion binding]; other site
435590004245	signature motif; other site
435590004246	putative dimer interface [polypeptide binding]; other site
435590004247	putative phosphate binding site [ion binding]; other site
435590004248	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004249	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590004250	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590004251	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590004252	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004253	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004254	DNA binding residues [nucleotide binding]
435590004255	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
435590004256	Na2 binding site [ion binding]; other site
435590004257	putative substrate binding site 1 [chemical binding]; other site
435590004258	Na binding site 1 [ion binding]; other site
435590004259	putative substrate binding site 2 [chemical binding]; other site
435590004260	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004261	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
435590004262	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004263	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004264	Transposase domain (DUF772); Region: DUF772; pfam05598
435590004265	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590004266	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
435590004267	dimer interface [polypeptide binding]; other site
435590004268	Alkaline phosphatase homologues; Region: alkPPc; smart00098
435590004269	active site
435590004270	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
435590004271	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590004272	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004273	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590004274	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590004275	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590004276	Divergent AAA domain; Region: AAA_4; pfam04326
435590004277	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590004278	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
435590004279	putative DNA binding site [nucleotide binding]; other site
435590004280	putative Zn2+ binding site [ion binding]; other site
435590004281	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
435590004282	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590004283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004284	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590004285	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590004286	active site
435590004287	substrate binding site [chemical binding]; other site
435590004288	trimer interface [polypeptide binding]; other site
435590004289	CoA binding site [chemical binding]; other site
435590004290	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590004291	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
435590004292	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
435590004293	active site
435590004294	catalytic triad [active]
435590004295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590004296	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590004297	Walker A motif; other site
435590004298	ATP binding site [chemical binding]; other site
435590004299	Walker B motif; other site
435590004300	arginine finger; other site
435590004301	CHC2 zinc finger; Region: zf-CHC2; cl17510
435590004302	Toprim-like; Region: Toprim_2; pfam13155
435590004303	active site
435590004304	metal binding site [ion binding]; metal-binding site
435590004305	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590004306	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590004307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590004308	Walker A motif; other site
435590004309	ATP binding site [chemical binding]; other site
435590004310	Walker B motif; other site
435590004311	Nuclease-related domain; Region: NERD; pfam08378
435590004312	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
435590004313	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
435590004314	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590004315	ATP binding site [chemical binding]; other site
435590004316	putative Mg++ binding site [ion binding]; other site
435590004317	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
435590004318	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590004319	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590004320	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590004321	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590004322	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590004323	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590004324	DNA binding residues [nucleotide binding]
435590004325	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
435590004326	putative metal binding site [ion binding]; other site
435590004327	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
435590004328	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
435590004329	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
435590004330	ATP binding site [chemical binding]; other site
435590004331	substrate interface [chemical binding]; other site
435590004332	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
435590004333	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
435590004334	PRTRC system protein E; Region: PRTRC_E; TIGR03741
435590004335	DNA topoisomerase III; Provisional; Region: PRK07726
435590004336	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590004337	active site
435590004338	putative interdomain interaction site [polypeptide binding]; other site
435590004339	putative metal-binding site [ion binding]; other site
435590004340	putative nucleotide binding site [chemical binding]; other site
435590004341	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
435590004342	domain I; other site
435590004343	DNA binding groove [nucleotide binding]
435590004344	phosphate binding site [ion binding]; other site
435590004345	domain II; other site
435590004346	domain III; other site
435590004347	nucleotide binding site [chemical binding]; other site
435590004348	catalytic site [active]
435590004349	domain IV; other site
435590004350	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590004351	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590004352	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004353	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004354	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004355	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004356	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590004357	active site
435590004358	DNA binding site [nucleotide binding]
435590004359	Int/Topo IB signature motif; other site
435590004360	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590004361	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
435590004362	homodimer interface [polypeptide binding]; other site
435590004363	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
435590004364	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590004365	Mg++ binding site [ion binding]; other site
435590004366	putative catalytic motif [active]
435590004367	substrate binding site [chemical binding]; other site
435590004368	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590004369	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590004370	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590004371	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590004372	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590004373	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
435590004374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
435590004375	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
435590004376	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590004377	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
435590004378	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590004379	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590004380	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004381	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590004382	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
435590004383	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
435590004384	NAD(P) binding site [chemical binding]; other site
435590004385	homodimer interface [polypeptide binding]; other site
435590004386	substrate binding site [chemical binding]; other site
435590004387	active site
435590004388	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
435590004389	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
435590004390	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
435590004391	putative NAD(P) binding site [chemical binding]; other site
435590004392	active site
435590004393	putative substrate binding site [chemical binding]; other site
435590004394	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
435590004395	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
435590004396	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590004397	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590004398	active site
435590004399	homodimer interface [polypeptide binding]; other site
435590004400	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004401	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590004402	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590004403	putative trimer interface [polypeptide binding]; other site
435590004404	putative CoA binding site [chemical binding]; other site
435590004405	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590004406	putative trimer interface [polypeptide binding]; other site
435590004407	putative CoA binding site [chemical binding]; other site
435590004408	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
435590004409	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
435590004410	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590004411	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590004412	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590004413	active site
435590004414	homodimer interface [polypeptide binding]; other site
435590004415	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590004416	ATP binding site [chemical binding]; other site
435590004417	putative Mg++ binding site [ion binding]; other site
435590004418	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590004419	nucleotide binding region [chemical binding]; other site
435590004420	ATP-binding site [chemical binding]; other site
435590004421	Helicase associated domain; Region: HA; pfam03457
435590004422	Helicase associated domain; Region: HA; pfam03457
435590004423	Helicase associated domain; Region: HA; pfam03457
435590004424	Helicase associated domain; Region: HA; pfam03457
435590004425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590004426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590004427	dimer interface [polypeptide binding]; other site
435590004428	phosphorylation site [posttranslational modification]
435590004429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004430	ATP binding site [chemical binding]; other site
435590004431	Mg2+ binding site [ion binding]; other site
435590004432	G-X-G motif; other site
435590004433	Response regulator receiver domain; Region: Response_reg; pfam00072
435590004434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004435	active site
435590004436	phosphorylation site [posttranslational modification]
435590004437	intermolecular recognition site; other site
435590004438	dimerization interface [polypeptide binding]; other site
435590004439	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590004440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004441	active site
435590004442	phosphorylation site [posttranslational modification]
435590004443	intermolecular recognition site; other site
435590004444	dimerization interface [polypeptide binding]; other site
435590004445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590004446	Walker A motif; other site
435590004447	ATP binding site [chemical binding]; other site
435590004448	Walker B motif; other site
435590004449	arginine finger; other site
435590004450	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590004451	RibD C-terminal domain; Region: RibD_C; cl17279
435590004452	YWFCY protein; Region: YWFCY; pfam14293
435590004453	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590004454	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
435590004455	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
435590004456	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
435590004457	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590004458	P-loop; other site
435590004459	Magnesium ion binding site [ion binding]; other site
435590004460	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590004461	Domain of unknown function (DUF4122); Region: DUF4122; pfam13498
435590004462	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590004463	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590004464	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590004465	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
435590004466	Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992
435590004467	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590004468	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590004469	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590004470	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590004471	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590004472	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590004473	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590004474	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590004475	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590004476	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590004477	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
435590004478	catalytic residue [active]
435590004479	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004480	metal binding site [ion binding]; metal-binding site
435590004481	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590004482	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590004483	Domain of unknown function (DUF4120); Region: DUF4120; pfam13496
435590004484	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590004485	HSP70 interaction site [polypeptide binding]; other site
435590004486	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
435590004487	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
435590004488	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004489	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
435590004490	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004492	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590004493	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590004494	Int/Topo IB signature motif; other site
435590004495	thiamine-monophosphate kinase; Region: thiL; TIGR01379
435590004496	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
435590004497	ATP binding site [chemical binding]; other site
435590004498	dimerization interface [polypeptide binding]; other site
435590004499	purine nucleoside phosphorylase; Provisional; Region: PRK08202
435590004500	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
435590004501	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
435590004502	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
435590004503	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
435590004504	tandem repeat interface [polypeptide binding]; other site
435590004505	oligomer interface [polypeptide binding]; other site
435590004506	active site residues [active]
435590004507	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
435590004508	tandem repeat interface [polypeptide binding]; other site
435590004509	oligomer interface [polypeptide binding]; other site
435590004510	active site residues [active]
435590004511	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
435590004512	dimer interface [polypeptide binding]; other site
435590004513	FMN binding site [chemical binding]; other site
435590004514	bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412
435590004515	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
435590004516	glycerate kinase; Region: TIGR00045
435590004517	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590004518	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590004519	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
435590004520	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590004521	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590004522	PBP superfamily domain; Region: PBP_like_2; pfam12849
435590004523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004524	binding surface
435590004525	TPR motif; other site
435590004526	TPR repeat; Region: TPR_11; pfam13414
435590004527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004528	binding surface
435590004529	TPR motif; other site
435590004530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004531	binding surface
435590004532	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590004533	TPR motif; other site
435590004534	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
435590004535	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
435590004536	Walker A/P-loop; other site
435590004537	ATP binding site [chemical binding]; other site
435590004538	Q-loop/lid; other site
435590004539	ABC transporter signature motif; other site
435590004540	Walker B; other site
435590004541	D-loop; other site
435590004542	H-loop/switch region; other site
435590004543	Predicted transcriptional regulators [Transcription]; Region: COG1725
435590004544	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
435590004545	DNA-binding site [nucleotide binding]; DNA binding site
435590004546	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004547	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
435590004548	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004549	Peptidase family M28; Region: Peptidase_M28; pfam04389
435590004550	metal binding site [ion binding]; metal-binding site
435590004551	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590004552	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
435590004553	adenylosuccinate lyase; Provisional; Region: PRK09285
435590004554	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
435590004555	tetramer interface [polypeptide binding]; other site
435590004556	active site
435590004557	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
435590004558	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590004559	RNA binding surface [nucleotide binding]; other site
435590004560	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
435590004561	active site
435590004562	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
435590004563	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
435590004564	putative dimer interface [polypeptide binding]; other site
435590004565	putative anticodon binding site; other site
435590004566	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
435590004567	homodimer interface [polypeptide binding]; other site
435590004568	motif 1; other site
435590004569	motif 2; other site
435590004570	active site
435590004571	motif 3; other site
435590004572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
435590004573	AAA domain; Region: AAA_33; pfam13671
435590004574	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
435590004575	23S rRNA interface [nucleotide binding]; other site
435590004576	L3 interface [polypeptide binding]; other site
435590004577	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
435590004578	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
435590004579	rRNA interaction site [nucleotide binding]; other site
435590004580	S8 interaction site; other site
435590004581	putative laminin-1 binding site; other site
435590004582	elongation factor Ts; Provisional; Region: tsf; PRK09377
435590004583	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
435590004584	Elongation factor TS; Region: EF_TS; pfam00889
435590004585	Elongation factor TS; Region: EF_TS; pfam00889
435590004586	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
435590004587	putative rRNA binding site [nucleotide binding]; other site
435590004588	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
435590004589	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
435590004590	CoA binding domain; Region: CoA_binding; pfam02629
435590004591	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
435590004592	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
435590004593	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
435590004594	homotrimer interaction site [polypeptide binding]; other site
435590004595	zinc binding site [ion binding]; other site
435590004596	CDP-binding sites; other site
435590004597	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
435590004598	UbiA prenyltransferase family; Region: UbiA; pfam01040
435590004599	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
435590004600	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590004601	putative active site [active]
435590004602	putative metal binding site [ion binding]; other site
435590004603	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590004604	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
435590004605	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
435590004606	active site
435590004607	(T/H)XGH motif; other site
435590004608	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
435590004609	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
435590004610	catalytic site [active]
435590004611	G-X2-G-X-G-K; other site
435590004612	hypothetical protein; Provisional; Region: PRK11820
435590004613	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
435590004614	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
435590004615	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
435590004616	Glycoprotease family; Region: Peptidase_M22; pfam00814
435590004617	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
435590004618	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
435590004619	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
435590004620	hinge; other site
435590004621	active site
435590004622	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
435590004623	RimM N-terminal domain; Region: RimM; pfam01782
435590004624	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590004625	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590004626	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
435590004627	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
435590004628	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
435590004629	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
435590004630	RIP metalloprotease RseP; Region: TIGR00054
435590004631	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
435590004632	active site
435590004633	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
435590004634	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
435590004635	protein binding site [polypeptide binding]; other site
435590004636	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
435590004637	putative substrate binding region [chemical binding]; other site
435590004638	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
435590004639	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
435590004640	ATP cone domain; Region: ATP-cone; pfam03477
435590004641	Class III ribonucleotide reductase; Region: RNR_III; cd01675
435590004642	effector binding site; other site
435590004643	active site
435590004644	Zn binding site [ion binding]; other site
435590004645	glycine loop; other site
435590004646	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
435590004647	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
435590004648	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
435590004649	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
435590004650	active site
435590004651	NTP binding site [chemical binding]; other site
435590004652	metal binding triad [ion binding]; metal-binding site
435590004653	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
435590004654	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590004655	Zn2+ binding site [ion binding]; other site
435590004656	Mg2+ binding site [ion binding]; other site
435590004657	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
435590004658	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
435590004659	RuvA N terminal domain; Region: RuvA_N; pfam01330
435590004660	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
435590004661	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
435590004662	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590004663	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
435590004664	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590004665	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590004666	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
435590004667	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
435590004668	substrate binding [chemical binding]; other site
435590004669	active site
435590004670	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
435590004671	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590004672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004673	putative substrate translocation pore; other site
435590004674	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590004675	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
435590004676	putative substrate binding site [chemical binding]; other site
435590004677	putative ATP binding site [chemical binding]; other site
435590004678	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
435590004679	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
435590004680	putative ligand binding site [chemical binding]; other site
435590004681	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590004682	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590004683	dimer interface [polypeptide binding]; other site
435590004684	phosphorylation site [posttranslational modification]
435590004685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004686	ATP binding site [chemical binding]; other site
435590004687	Mg2+ binding site [ion binding]; other site
435590004688	G-X-G motif; other site
435590004689	Response regulator receiver domain; Region: Response_reg; pfam00072
435590004690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004691	active site
435590004692	phosphorylation site [posttranslational modification]
435590004693	intermolecular recognition site; other site
435590004694	dimerization interface [polypeptide binding]; other site
435590004695	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590004696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004697	ACT domain-containing protein [General function prediction only]; Region: COG4747
435590004698	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
435590004699	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590004700	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
435590004701	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590004702	acyl-activating enzyme (AAE) consensus motif; other site
435590004703	AMP binding site [chemical binding]; other site
435590004704	active site
435590004705	CoA binding site [chemical binding]; other site
435590004706	Protein of unknown function (DUF3256); Region: DUF3256; pfam11644
435590004707	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
435590004708	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
435590004709	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
435590004710	intersubunit interface [polypeptide binding]; other site
435590004711	active site
435590004712	zinc binding site [ion binding]; other site
435590004713	Na+ binding site [ion binding]; other site
435590004714	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590004715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004716	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590004717	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590004718	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590004719	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590004720	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
435590004721	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590004722	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
435590004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004724	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590004725	putative substrate translocation pore; other site
435590004726	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
435590004727	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
435590004728	putative substrate binding site [chemical binding]; other site
435590004729	putative ATP binding site [chemical binding]; other site
435590004730	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590004731	active site
435590004732	adenylate kinase; Reviewed; Region: adk; PRK00279
435590004733	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
435590004734	AMP-binding site [chemical binding]; other site
435590004735	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
435590004736	GTPase CgtA; Reviewed; Region: obgE; PRK12298
435590004737	GTP1/OBG; Region: GTP1_OBG; pfam01018
435590004738	Obg GTPase; Region: Obg; cd01898
435590004739	G1 box; other site
435590004740	GTP/Mg2+ binding site [chemical binding]; other site
435590004741	Switch I region; other site
435590004742	G2 box; other site
435590004743	G3 box; other site
435590004744	Switch II region; other site
435590004745	G4 box; other site
435590004746	G5 box; other site
435590004747	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
435590004748	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
435590004749	B3/4 domain; Region: B3_4; smart00873
435590004750	B3/4 domain; Region: B3_4; pfam03483
435590004751	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590004752	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590004753	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590004754	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590004755	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590004756	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590004757	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590004758	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
435590004759	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
435590004760	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
435590004761	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
435590004762	tetramer interface [polypeptide binding]; other site
435590004763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590004764	catalytic residue [active]
435590004765	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004766	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
435590004767	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590004768	N-terminal plug; other site
435590004769	ligand-binding site [chemical binding]; other site
435590004770	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
435590004771	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
435590004772	ligand binding site [chemical binding]; other site
435590004773	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
435590004774	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590004775	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590004776	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590004777	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004778	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004779	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004780	DNA binding residues [nucleotide binding]
435590004781	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004782	FecR protein; Region: FecR; pfam04773
435590004783	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004784	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004785	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590004786	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590004787	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590004788	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004789	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
435590004790	putative active site [active]
435590004791	catalytic site [active]
435590004792	putative metal binding site [ion binding]; other site
435590004793	oligomer interface [polypeptide binding]; other site
435590004794	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
435590004795	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
435590004796	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590004797	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590004798	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590004799	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590004800	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590004801	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590004802	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590004803	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590004804	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590004805	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590004806	metal-binding site
435590004807	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004808	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
435590004809	putative ADP-binding pocket [chemical binding]; other site
435590004810	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
435590004811	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004812	Core-2/I-Branching enzyme; Region: Branch; pfam02485
435590004813	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590004814	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590004815	active site
435590004816	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
435590004817	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590004818	Mg++ binding site [ion binding]; other site
435590004819	putative catalytic motif [active]
435590004820	substrate binding site [chemical binding]; other site
435590004821	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590004822	VirE N-terminal domain; Region: VirE_N; pfam08800
435590004823	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590004824	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590004825	Protein of unknown function (DUF3853); Region: DUF3853; pfam12964
435590004826	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004827	active site
435590004828	DNA binding site [nucleotide binding]
435590004829	Int/Topo IB signature motif; other site
435590004830	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
435590004831	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590004832	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
435590004833	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
435590004834	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
435590004835	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590004836	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004838	Mg2+ binding site [ion binding]; other site
435590004839	G-X-G motif; other site
435590004840	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004841	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
435590004842	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
435590004843	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
435590004844	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
435590004845	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
435590004846	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
435590004847	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
435590004848	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
435590004849	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
435590004850	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
435590004851	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
435590004852	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590004853	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
435590004854	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
435590004855	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
435590004856	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
435590004857	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
435590004858	NADH dehydrogenase subunit B; Provisional; Region: PRK14816
435590004859	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
435590004860	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
435590004861	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
435590004862	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
435590004863	TrkA-N domain; Region: TrkA_N; pfam02254
435590004864	TrkA-C domain; Region: TrkA_C; pfam02080
435590004865	TrkA-N domain; Region: TrkA_N; pfam02254
435590004866	TrkA-C domain; Region: TrkA_C; pfam02080
435590004867	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
435590004868	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
435590004869	TPP-binding site; other site
435590004870	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590004871	PYR/PP interface [polypeptide binding]; other site
435590004872	dimer interface [polypeptide binding]; other site
435590004873	TPP binding site [chemical binding]; other site
435590004874	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590004875	GSCFA family; Region: GSCFA; pfam08885
435590004876	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
435590004877	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590004878	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590004879	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
435590004880	active site
435590004881	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590004882	dimer interface [polypeptide binding]; other site
435590004883	substrate binding site [chemical binding]; other site
435590004884	catalytic residues [active]
435590004885	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004886	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590004887	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004888	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590004889	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590004890	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004891	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590004892	active site
435590004893	catalytic triad [active]
435590004894	oxyanion hole [active]
435590004895	Sulfatase; Region: Sulfatase; cl17466
435590004896	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590004897	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590004898	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590004899	SusD family; Region: SusD; pfam07980
435590004900	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590004901	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004902	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004903	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590004904	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590004905	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590004906	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004907	FecR protein; Region: FecR; pfam04773
435590004908	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004909	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004910	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004911	DNA binding residues [nucleotide binding]
435590004912	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590004913	Virulence-associated protein E; Region: VirE; pfam05272
435590004914	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590004915	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004916	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004917	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004918	DNA binding residues [nucleotide binding]
435590004919	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004920	FecR protein; Region: FecR; pfam04773
435590004921	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590004922	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004923	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004924	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590004925	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590004926	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590004927	SusD family; Region: SusD; pfam07980
435590004928	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004929	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
435590004930	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590004931	beta-D-glucuronidase; Provisional; Region: PRK10150
435590004932	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004933	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590004934	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
435590004935	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
435590004936	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
435590004937	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590004938	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590004939	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590004940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004941	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
435590004942	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
435590004943	NAD binding site [chemical binding]; other site
435590004944	catalytic residues [active]
435590004945	substrate binding site [chemical binding]; other site
435590004946	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590004947	active site
435590004948	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590004949	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
435590004950	AAA domain; Region: AAA_11; pfam13086
435590004951	AAA domain; Region: AAA_30; pfam13604
435590004952	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
435590004953	AAA domain; Region: AAA_12; pfam13087
435590004954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004955	putative substrate translocation pore; other site
435590004956	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
435590004957	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
435590004958	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
435590004959	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004960	putative pectinesterase; Region: PLN02432; cl01911
435590004961	Pectinesterase; Region: Pectinesterase; pfam01095
435590004962	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004963	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004964	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590004965	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590004966	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590004967	SusD family; Region: SusD; pfam07980
435590004968	Uncharacterized conserved protein [Function unknown]; Region: COG1262
435590004969	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
435590004970	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
435590004971	BNR repeat-like domain; Region: BNR_2; pfam13088
435590004972	Asp-box motif; other site
435590004973	putative pectinesterase; Region: PLN02432; cl01911
435590004974	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004975	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004976	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004977	DNA binding residues [nucleotide binding]
435590004978	FecR protein; Region: FecR; pfam04773
435590004979	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004980	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590004981	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004982	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590004983	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590004984	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590004985	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590004986	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004987	SusD family; Region: SusD; pfam07980
435590004988	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590004989	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004990	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590004991	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590004992	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004993	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590004994	PA14 domain; Region: PA14; cl08459
435590004995	putative alpha-glucosidase; Provisional; Region: PRK10658
435590004996	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590004997	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
435590004998	active site
435590004999	catalytic site [active]
435590005000	Abhydrolase family; Region: Abhydrolase_7; pfam12715
435590005001	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
435590005002	Pectic acid lyase; Region: Pec_lyase; pfam09492
435590005003	Abhydrolase family; Region: Abhydrolase_7; pfam12715
435590005004	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
435590005005	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590005006	active site
435590005007	catalytic triad [active]
435590005008	Pectinesterase; Region: Pectinesterase; pfam01095
435590005009	putative pectinesterase; Region: PLN02432; cl01911
435590005010	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005011	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005012	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005015	dimer interface [polypeptide binding]; other site
435590005016	phosphorylation site [posttranslational modification]
435590005017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005018	ATP binding site [chemical binding]; other site
435590005019	Mg2+ binding site [ion binding]; other site
435590005020	G-X-G motif; other site
435590005021	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590005022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005023	active site
435590005024	phosphorylation site [posttranslational modification]
435590005025	intermolecular recognition site; other site
435590005026	dimerization interface [polypeptide binding]; other site
435590005027	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590005028	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005029	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590005030	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590005031	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590005032	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590005033	Phosphotransferase enzyme family; Region: APH; pfam01636
435590005034	Phosphate transporter family; Region: PHO4; cl00396
435590005035	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
435590005036	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
435590005037	purine monophosphate binding site [chemical binding]; other site
435590005038	dimer interface [polypeptide binding]; other site
435590005039	putative catalytic residues [active]
435590005040	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
435590005041	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
435590005042	rod shape-determining protein MreB; Provisional; Region: PRK13927
435590005043	MreB and similar proteins; Region: MreB_like; cd10225
435590005044	nucleotide binding site [chemical binding]; other site
435590005045	Mg binding site [ion binding]; other site
435590005046	putative protofilament interaction site [polypeptide binding]; other site
435590005047	RodZ interaction site [polypeptide binding]; other site
435590005048	rod shape-determining protein MreC; Provisional; Region: PRK13922
435590005049	rod shape-determining protein MreC; Region: MreC; pfam04085
435590005050	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
435590005051	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
435590005052	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
435590005053	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
435590005054	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
435590005055	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
435590005056	GldH lipoprotein; Region: GldH_lipo; pfam14109
435590005057	PSP1 C-terminal conserved region; Region: PSP1; cl00770
435590005058	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
435590005059	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
435590005060	DNA polymerase III subunit delta'; Validated; Region: PRK08485
435590005061	DNA polymerase III subunit delta'; Validated; Region: PRK05564
435590005062	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
435590005063	FAD binding site [chemical binding]; other site
435590005064	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
435590005065	PLD-like domain; Region: PLDc_2; pfam13091
435590005066	putative active site [active]
435590005067	catalytic site [active]
435590005068	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
435590005069	PLD-like domain; Region: PLDc_2; pfam13091
435590005070	putative active site [active]
435590005071	catalytic site [active]
435590005072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
435590005073	Domain of unknown function DUF20; Region: UPF0118; pfam01594
435590005074	thymidine kinase; Provisional; Region: PRK04296
435590005075	Predicted methyltransferases [General function prediction only]; Region: COG0313
435590005076	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
435590005077	putative SAM binding site [chemical binding]; other site
435590005078	putative homodimer interface [polypeptide binding]; other site
435590005079	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
435590005080	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
435590005081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590005082	motif II; other site
435590005083	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005084	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005085	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005086	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005087	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005088	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590005089	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590005090	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590005091	active site
435590005092	DNA binding site [nucleotide binding]
435590005093	Int/Topo IB signature motif; other site
435590005094	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005095	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590005096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005097	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005098	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005099	HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]; Region: HRD1; COG5243
435590005100	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005101	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005102	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005103	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005104	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590005106	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590005107	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590005108	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005109	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005110	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590005111	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005112	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005113	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005114	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005115	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590005116	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590005117	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005118	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005119	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005120	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005121	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005122	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005123	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005124	SusD family; Region: SusD; pfam07980
435590005125	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
435590005126	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
435590005127	HflX GTPase family; Region: HflX; cd01878
435590005128	G1 box; other site
435590005129	GTP/Mg2+ binding site [chemical binding]; other site
435590005130	Switch I region; other site
435590005131	G2 box; other site
435590005132	G3 box; other site
435590005133	Switch II region; other site
435590005134	G4 box; other site
435590005135	G5 box; other site
435590005136	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590005137	putative trimer interface [polypeptide binding]; other site
435590005138	putative CoA binding site [chemical binding]; other site
435590005139	Predicted acyl esterases [General function prediction only]; Region: COG2936
435590005140	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
435590005141	fumarate hydratase; Provisional; Region: PRK15389
435590005142	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
435590005143	Fumarase C-terminus; Region: Fumerase_C; pfam05683
435590005144	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
435590005145	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
435590005146	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
435590005147	amino acid transporter; Region: 2A0306; TIGR00909
435590005148	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
435590005149	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
435590005150	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590005151	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590005152	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590005153	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590005154	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
435590005155	Peptidase family M28; Region: Peptidase_M28; pfam04389
435590005156	metal binding site [ion binding]; metal-binding site
435590005157	GTPase RsgA; Reviewed; Region: PRK00098
435590005158	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
435590005159	RNA binding site [nucleotide binding]; other site
435590005160	homodimer interface [polypeptide binding]; other site
435590005161	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
435590005162	GTPase/Zn-binding domain interface [polypeptide binding]; other site
435590005163	GTP/Mg2+ binding site [chemical binding]; other site
435590005164	G4 box; other site
435590005165	G5 box; other site
435590005166	G1 box; other site
435590005167	Switch I region; other site
435590005168	G2 box; other site
435590005169	G3 box; other site
435590005170	Switch II region; other site
435590005171	ribosome recycling factor; Reviewed; Region: frr; PRK00083
435590005172	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
435590005173	hinge region; other site
435590005174	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590005175	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590005176	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590005177	catalytic core [active]
435590005178	N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067
435590005179	Protein of unknown function, DUF608; Region: DUF608; pfam04685
435590005180	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590005181	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
435590005182	putative nucleotide binding site [chemical binding]; other site
435590005183	uridine monophosphate binding site [chemical binding]; other site
435590005184	homohexameric interface [polypeptide binding]; other site
435590005185	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
435590005186	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
435590005187	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590005188	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590005189	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
435590005190	Catalytic dyad [active]
435590005191	Transposase domain (DUF772); Region: DUF772; pfam05598
435590005192	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590005193	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
435590005194	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
435590005195	Protein of unknown function (DUF419); Region: DUF419; pfam04237
435590005196	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
435590005197	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
435590005198	nucleoside/Zn binding site; other site
435590005199	dimer interface [polypeptide binding]; other site
435590005200	catalytic motif [active]
435590005201	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
435590005202	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
435590005203	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
435590005204	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
435590005205	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
435590005206	active site
435590005207	PHP Thumb interface [polypeptide binding]; other site
435590005208	metal binding site [ion binding]; metal-binding site
435590005209	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
435590005210	generic binding surface II; other site
435590005211	generic binding surface I; other site
435590005212	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590005213	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590005214	catalytic residues [active]
435590005215	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
435590005216	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
435590005217	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
435590005218	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590005219	ABC-ATPase subunit  interface; other site
435590005220	dimer interface [polypeptide binding]; other site
435590005221	putative PBP binding regions; other site
435590005222	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
435590005223	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
435590005224	hinge; other site
435590005225	active site
435590005226	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
435590005227	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
435590005228	putative active site; other site
435590005229	catalytic residue [active]
435590005230	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590005231	catalytic core [active]
435590005232	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590005233	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
435590005234	DNA polymerase IV; Validated; Region: PRK02406
435590005235	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
435590005236	active site
435590005237	DNA binding site [nucleotide binding]
435590005238	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005239	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
435590005240	active site
435590005241	dimer interface [polypeptide binding]; other site
435590005242	metal binding site [ion binding]; metal-binding site
435590005243	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005244	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005245	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
435590005246	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
435590005247	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
435590005248	putative active site [active]
435590005249	catalytic site [active]
435590005250	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
435590005251	putative active site [active]
435590005252	catalytic site [active]
435590005253	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
435590005254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590005255	S-adenosylmethionine binding site [chemical binding]; other site
435590005256	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
435590005257	AAA domain; Region: AAA_30; pfam13604
435590005258	Family description; Region: UvrD_C_2; pfam13538
435590005259	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
435590005260	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
435590005261	motif 1; other site
435590005262	active site
435590005263	motif 2; other site
435590005264	motif 3; other site
435590005265	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
435590005266	DHHA1 domain; Region: DHHA1; pfam02272
435590005267	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
435590005268	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590005269	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590005270	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
435590005271	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
435590005272	DNA binding residues [nucleotide binding]
435590005273	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
435590005274	HD domain; Region: HD_4; pfam13328
435590005275	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
435590005276	synthetase active site [active]
435590005277	NTP binding site [chemical binding]; other site
435590005278	metal binding site [ion binding]; metal-binding site
435590005279	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
435590005280	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
435590005281	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
435590005282	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
435590005283	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590005284	catalytic residue [active]
435590005285	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590005286	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
435590005287	ParB-like nuclease domain; Region: ParBc; pfam02195
435590005288	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590005289	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590005290	P-loop; other site
435590005291	Magnesium ion binding site [ion binding]; other site
435590005292	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590005293	Magnesium ion binding site [ion binding]; other site
435590005294	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
435590005295	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
435590005296	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
435590005297	NigD-like protein; Region: NigD; pfam12667
435590005298	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
435590005299	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
435590005300	FtsH Extracellular; Region: FtsH_ext; pfam06480
435590005301	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
435590005302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590005303	Walker A motif; other site
435590005304	ATP binding site [chemical binding]; other site
435590005305	Walker B motif; other site
435590005306	arginine finger; other site
435590005307	Peptidase family M41; Region: Peptidase_M41; pfam01434
435590005308	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
435590005309	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005310	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005311	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005312	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005313	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005314	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
435590005315	MgtE intracellular N domain; Region: MgtE_N; smart00924
435590005316	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
435590005317	Divalent cation transporter; Region: MgtE; pfam01769
435590005318	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
435590005319	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
435590005320	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
435590005321	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
435590005322	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
435590005323	metal binding site [ion binding]; metal-binding site
435590005324	dimer interface [polypeptide binding]; other site
435590005325	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
435590005326	nucleoside/Zn binding site; other site
435590005327	dimer interface [polypeptide binding]; other site
435590005328	catalytic motif [active]
435590005329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590005330	non-specific DNA binding site [nucleotide binding]; other site
435590005331	salt bridge; other site
435590005332	sequence-specific DNA binding site [nucleotide binding]; other site
435590005333	MG2 domain; Region: A2M_N; pfam01835
435590005334	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
435590005335	Alpha-2-macroglobulin family; Region: A2M; pfam00207
435590005336	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
435590005337	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590005338	membrane ATPase/protein kinase; Provisional; Region: PRK09435
435590005339	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
435590005340	Walker A; other site
435590005341	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
435590005342	G4 box; other site
435590005343	G5 box; other site
435590005344	6-phosphofructokinase; Provisional; Region: PRK03202
435590005345	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
435590005346	active site
435590005347	ADP/pyrophosphate binding site [chemical binding]; other site
435590005348	dimerization interface [polypeptide binding]; other site
435590005349	allosteric effector site; other site
435590005350	fructose-1,6-bisphosphate binding site; other site
435590005351	LytB protein; Region: LYTB; cl00507
435590005352	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
435590005353	cytidylate kinase; Provisional; Region: cmk; PRK00023
435590005354	AAA domain; Region: AAA_17; pfam13207
435590005355	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
435590005356	CMP-binding site; other site
435590005357	The sites determining sugar specificity; other site
435590005358	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590005359	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590005360	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
435590005361	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
435590005362	substrate binding pocket [chemical binding]; other site
435590005363	chain length determination region; other site
435590005364	substrate-Mg2+ binding site; other site
435590005365	catalytic residues [active]
435590005366	aspartate-rich region 1; other site
435590005367	active site lid residues [active]
435590005368	aspartate-rich region 2; other site
435590005369	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
435590005370	active site
435590005371	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
435590005372	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
435590005373	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
435590005374	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
435590005375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590005376	Coenzyme A binding pocket [chemical binding]; other site
435590005377	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
435590005378	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
435590005379	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
435590005380	AsnC family; Region: AsnC_trans_reg; pfam01037
435590005381	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
435590005382	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
435590005383	folate binding site [chemical binding]; other site
435590005384	NADP+ binding site [chemical binding]; other site
435590005385	thymidylate synthase; Reviewed; Region: thyA; PRK01827
435590005386	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
435590005387	dimerization interface [polypeptide binding]; other site
435590005388	active site
435590005389	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
435590005390	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005391	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005392	DNA binding residues [nucleotide binding]
435590005393	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
435590005394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590005395	S-adenosylmethionine binding site [chemical binding]; other site
435590005396	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
435590005397	DNA topoisomerase III; Provisional; Region: PRK07726
435590005398	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590005399	active site
435590005400	putative interdomain interaction site [polypeptide binding]; other site
435590005401	putative metal-binding site [ion binding]; other site
435590005402	putative nucleotide binding site [chemical binding]; other site
435590005403	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
435590005404	domain I; other site
435590005405	phosphate binding site [ion binding]; other site
435590005406	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590005407	domain II; other site
435590005408	domain III; other site
435590005409	nucleotide binding site [chemical binding]; other site
435590005410	DNA binding groove [nucleotide binding]
435590005411	catalytic site [active]
435590005412	domain IV; other site
435590005413	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005414	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005415	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005416	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590005417	subunit interaction site [polypeptide binding]; other site
435590005418	PHB binding site; other site
435590005419	CoenzymeA binding site [chemical binding]; other site
435590005420	AAA domain; Region: AAA_11; pfam13086
435590005421	Part of AAA domain; Region: AAA_19; pfam13245
435590005422	AAA domain; Region: AAA_30; pfam13604
435590005423	AAA domain; Region: AAA_12; pfam13087
435590005424	aconitate hydratase; Validated; Region: PRK07229
435590005425	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
435590005426	substrate binding site [chemical binding]; other site
435590005427	ligand binding site [chemical binding]; other site
435590005428	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
435590005429	substrate binding site [chemical binding]; other site
435590005430	isocitrate dehydrogenase; Validated; Region: PRK06451
435590005431	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
435590005432	citrate synthase; Provisional; Region: PRK14032
435590005433	Citrate synthase; Region: Citrate_synt; pfam00285
435590005434	oxalacetate binding site [chemical binding]; other site
435590005435	citrylCoA binding site [chemical binding]; other site
435590005436	coenzyme A binding site [chemical binding]; other site
435590005437	catalytic triad [active]
435590005438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590005439	Coenzyme A binding pocket [chemical binding]; other site
435590005440	3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474
435590005441	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
435590005442	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
435590005443	active site
435590005444	FMN binding site [chemical binding]; other site
435590005445	substrate binding site [chemical binding]; other site
435590005446	putative catalytic residue [active]
435590005447	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
435590005448	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
435590005449	putative NAD(P) binding site [chemical binding]; other site
435590005450	active site
435590005451	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
435590005452	EamA-like transporter family; Region: EamA; pfam00892
435590005453	EamA-like transporter family; Region: EamA; pfam00892
435590005454	AAA domain; Region: AAA_21; pfam13304
435590005455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
435590005456	Q-loop/lid; other site
435590005457	ABC transporter signature motif; other site
435590005458	Walker B; other site
435590005459	D-loop; other site
435590005460	H-loop/switch region; other site
435590005461	Predicted membrane protein [Function unknown]; Region: COG2259
435590005462	6-phosphofructokinase; Provisional; Region: PRK03202
435590005463	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
435590005464	active site
435590005465	ADP/pyrophosphate binding site [chemical binding]; other site
435590005466	dimerization interface [polypeptide binding]; other site
435590005467	allosteric effector site; other site
435590005468	fructose-1,6-bisphosphate binding site; other site
435590005469	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590005470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590005471	motif II; other site
435590005472	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
435590005473	putative FMN binding site [chemical binding]; other site
435590005474	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
435590005475	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
435590005476	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
435590005477	active site
435590005478	catalytic residues [active]
435590005479	metal binding site [ion binding]; metal-binding site
435590005480	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
435590005481	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590005482	carboxyltransferase (CT) interaction site; other site
435590005483	biotinylation site [posttranslational modification]; other site
435590005484	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
435590005485	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005486	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590005487	catalytic residues [active]
435590005488	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590005489	catalytic residues [active]
435590005490	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005491	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005492	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005493	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005494	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005495	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590005496	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005497	FecR protein; Region: FecR; pfam04773
435590005498	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005499	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590005500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005501	DNA binding residues [nucleotide binding]
435590005502	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590005503	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590005504	active site
435590005505	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590005506	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005507	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
435590005508	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
435590005509	NAD binding site [chemical binding]; other site
435590005510	homotetramer interface [polypeptide binding]; other site
435590005511	homodimer interface [polypeptide binding]; other site
435590005512	substrate binding site [chemical binding]; other site
435590005513	active site
435590005514	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
435590005515	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
435590005516	putative SAM binding site [chemical binding]; other site
435590005517	homodimer interface [polypeptide binding]; other site
435590005518	lipoyl synthase; Provisional; Region: PRK05481
435590005519	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590005520	FeS/SAM binding site; other site
435590005521	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590005522	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
435590005523	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590005524	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
435590005525	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
435590005526	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
435590005527	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
435590005528	Conserved TM helix; Region: TM_helix; pfam05552
435590005529	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590005530	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
435590005531	PIF1-like helicase; Region: PIF1; pfam05970
435590005532	AAA domain; Region: AAA_30; pfam13604
435590005533	Family description; Region: UvrD_C_2; pfam13538
435590005534	TPR repeat; Region: TPR_11; pfam13414
435590005535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005536	binding surface
435590005537	TPR motif; other site
435590005538	TPR repeat; Region: TPR_11; pfam13414
435590005539	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590005540	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
435590005541	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
435590005542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
435590005543	2-isopropylmalate synthase; Validated; Region: PRK00915
435590005544	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
435590005545	active site
435590005546	catalytic residues [active]
435590005547	metal binding site [ion binding]; metal-binding site
435590005548	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
435590005549	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
435590005550	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
435590005551	substrate binding site [chemical binding]; other site
435590005552	ligand binding site [chemical binding]; other site
435590005553	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
435590005554	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
435590005555	substrate binding site [chemical binding]; other site
435590005556	(R)-citramalate synthase; Provisional; Region: PRK09389
435590005557	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
435590005558	active site
435590005559	catalytic residues [active]
435590005560	metal binding site [ion binding]; metal-binding site
435590005561	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
435590005562	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
435590005563	tartrate dehydrogenase; Region: TTC; TIGR02089
435590005564	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590005565	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005566	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590005567	catalytic residues [active]
435590005568	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
435590005569	TPR repeat; Region: TPR_11; pfam13414
435590005570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005571	binding surface
435590005572	TPR motif; other site
435590005573	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005574	binding surface
435590005575	TPR repeat; Region: TPR_11; pfam13414
435590005576	TPR motif; other site
435590005577	Transposase domain (DUF772); Region: DUF772; pfam05598
435590005578	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590005579	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
435590005580	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590005581	ATP binding site [chemical binding]; other site
435590005582	putative Mg++ binding site [ion binding]; other site
435590005583	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590005584	nucleotide binding region [chemical binding]; other site
435590005585	ATP-binding site [chemical binding]; other site
435590005586	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
435590005587	HRDC domain; Region: HRDC; pfam00570
435590005588	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005590	Peptidase family M49; Region: Peptidase_M49; pfam03571
435590005591	A new structural DNA glycosylase; Region: AlkD_like; cd06561
435590005592	active site
435590005593	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
435590005594	metal binding site 2 [ion binding]; metal-binding site
435590005595	putative DNA binding helix; other site
435590005596	metal binding site 1 [ion binding]; metal-binding site
435590005597	dimer interface [polypeptide binding]; other site
435590005598	structural Zn2+ binding site [ion binding]; other site
435590005599	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
435590005600	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
435590005601	GDP-binding site [chemical binding]; other site
435590005602	ACT binding site; other site
435590005603	IMP binding site; other site
435590005604	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590005605	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005606	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005607	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590005608	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005609	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
435590005610	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005611	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005612	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590005613	active site
435590005614	catalytic triad [active]
435590005615	oxyanion hole [active]
435590005616	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590005617	oxyanion hole [active]
435590005618	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590005619	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005620	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005621	DNA binding residues [nucleotide binding]
435590005622	FecR protein; Region: FecR; pfam04773
435590005623	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005624	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005625	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005626	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005627	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590005628	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005629	SusD family; Region: SusD; pfam07980
435590005630	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
435590005631	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590005632	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590005633	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590005634	ABC transporter; Region: ABC_tran_2; pfam12848
435590005635	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590005636	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
435590005637	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
435590005638	active site
435590005639	Zn binding site [ion binding]; other site
435590005640	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590005641	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
435590005642	E3 interaction surface; other site
435590005643	lipoyl attachment site [posttranslational modification]; other site
435590005644	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
435590005645	Protein export membrane protein; Region: SecD_SecF; cl14618
435590005646	Outer membrane efflux protein; Region: OEP; pfam02321
435590005647	Outer membrane efflux protein; Region: OEP; pfam02321
435590005648	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
435590005649	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
435590005650	potential catalytic triad [active]
435590005651	conserved cys residue [active]
435590005652	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
435590005653	dimer interface [polypeptide binding]; other site
435590005654	FMN binding site [chemical binding]; other site
435590005655	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
435590005656	dimer interface [polypeptide binding]; other site
435590005657	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590005658	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590005659	homoserine O-succinyltransferase; Provisional; Region: PRK05368
435590005660	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
435590005661	proposed active site lysine [active]
435590005662	conserved cys residue [active]
435590005663	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
435590005664	Peptidase family U32; Region: Peptidase_U32; pfam01136
435590005665	Collagenase; Region: DUF3656; pfam12392
435590005666	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590005667	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005668	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590005669	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590005670	DNA binding residues [nucleotide binding]
435590005671	dimerization interface [polypeptide binding]; other site
435590005672	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
435590005673	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
435590005674	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
435590005675	DNA repair protein RadA; Provisional; Region: PRK11823
435590005676	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
435590005677	Walker A motif/ATP binding site; other site
435590005678	ATP binding site [chemical binding]; other site
435590005679	Walker B motif; other site
435590005680	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
435590005681	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
435590005682	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
435590005683	putative catalytic residues [active]
435590005684	putative nucleotide binding site [chemical binding]; other site
435590005685	putative aspartate binding site [chemical binding]; other site
435590005686	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
435590005687	dimer interface [polypeptide binding]; other site
435590005688	putative threonine allosteric regulatory site; other site
435590005689	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
435590005690	putative threonine allosteric regulatory site; other site
435590005691	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
435590005692	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
435590005693	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
435590005694	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
435590005695	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
435590005696	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
435590005697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005698	catalytic residue [active]
435590005699	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
435590005700	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
435590005701	Walker A/P-loop; other site
435590005702	ATP binding site [chemical binding]; other site
435590005703	Q-loop/lid; other site
435590005704	ABC transporter signature motif; other site
435590005705	Walker B; other site
435590005706	D-loop; other site
435590005707	H-loop/switch region; other site
435590005708	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
435590005709	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590005710	ABC-ATPase subunit  interface; other site
435590005711	dimer interface [polypeptide binding]; other site
435590005712	putative PBP binding regions; other site
435590005713	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
435590005714	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590005715	putative ligand binding site [chemical binding]; other site
435590005716	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
435590005717	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005718	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
435590005719	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
435590005720	Transposase domain (DUF772); Region: DUF772; pfam05598
435590005721	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590005722	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
435590005723	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
435590005724	prephenate dehydrogenase; Validated; Region: PRK08507
435590005725	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
435590005726	Chorismate mutase type II; Region: CM_2; smart00830
435590005727	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
435590005728	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005730	homodimer interface [polypeptide binding]; other site
435590005731	catalytic residue [active]
435590005732	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
435590005733	Prephenate dehydratase; Region: PDT; pfam00800
435590005734	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
435590005735	putative L-Phe binding site [chemical binding]; other site
435590005736	Predicted transcriptional regulators [Transcription]; Region: COG1733
435590005737	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
435590005738	intracellular protease, PfpI family; Region: PfpI; TIGR01382
435590005739	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590005740	conserved cys residue [active]
435590005741	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
435590005742	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005744	homodimer interface [polypeptide binding]; other site
435590005745	catalytic residue [active]
435590005746	Domain of unknown function DUF20; Region: UPF0118; pfam01594
435590005747	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
435590005748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005749	binding surface
435590005750	TPR motif; other site
435590005751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005752	binding surface
435590005753	TPR motif; other site
435590005754	TPR repeat; Region: TPR_11; pfam13414
435590005755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005756	binding surface
435590005757	TPR motif; other site
435590005758	TPR repeat; Region: TPR_11; pfam13414
435590005759	TPR repeat; Region: TPR_11; pfam13414
435590005760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005761	binding surface
435590005762	TPR motif; other site
435590005763	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
435590005764	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
435590005765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590005766	ATP binding site [chemical binding]; other site
435590005767	putative Mg++ binding site [ion binding]; other site
435590005768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590005769	nucleotide binding region [chemical binding]; other site
435590005770	ATP-binding site [chemical binding]; other site
435590005771	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
435590005772	DHH family; Region: DHH; pfam01368
435590005773	DHHA1 domain; Region: DHHA1; pfam02272
435590005774	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
435590005775	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
435590005776	proline aminopeptidase P II; Provisional; Region: PRK10879
435590005777	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
435590005778	active site
435590005779	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
435590005780	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
435590005781	active site
435590005782	nucleophile elbow; other site
435590005783	phosphodiesterase; Provisional; Region: PRK12704
435590005784	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590005785	Zn2+ binding site [ion binding]; other site
435590005786	Mg2+ binding site [ion binding]; other site
435590005787	Cell division protein ZapA; Region: ZapA; pfam05164
435590005788	Protein of unknown function (DUF454); Region: DUF454; cl01063
435590005789	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
435590005790	active site
435590005791	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
435590005792	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590005793	FeS/SAM binding site; other site
435590005794	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
435590005795	putative active site [active]
435590005796	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
435590005797	amino acid carrier protein; Region: agcS; TIGR00835
435590005798	Divergent AAA domain; Region: AAA_4; pfam04326
435590005799	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005800	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005803	dimer interface [polypeptide binding]; other site
435590005804	phosphorylation site [posttranslational modification]
435590005805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005806	ATP binding site [chemical binding]; other site
435590005807	Mg2+ binding site [ion binding]; other site
435590005808	G-X-G motif; other site
435590005809	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590005810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005811	Predicted acetyltransferase [General function prediction only]; Region: COG2388
435590005812	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
435590005813	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
435590005814	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
435590005815	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
435590005816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005817	binding surface
435590005818	TPR motif; other site
435590005819	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590005820	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005822	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590005823	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590005824	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590005825	Int/Topo IB signature motif; other site
435590005826	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590005827	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
435590005828	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590005829	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590005830	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
435590005831	G1 box; other site
435590005832	GTP/Mg2+ binding site [chemical binding]; other site
435590005833	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
435590005834	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
435590005835	putative active site [active]
435590005836	putative metal binding site [ion binding]; other site
435590005837	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590005838	Methyltransferase domain; Region: Methyltransf_26; pfam13659
435590005839	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
435590005840	DEAD-like helicases superfamily; Region: DEXDc; smart00487
435590005841	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
435590005842	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
435590005843	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590005844	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590005845	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590005846	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
435590005847	AAA domain; Region: AAA_14; pfam13173
435590005848	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590005849	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
435590005850	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
435590005851	YWFCY protein; Region: YWFCY; pfam14293
435590005852	YWFCY protein; Region: YWFCY; pfam14293
435590005853	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590005854	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590005855	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590005856	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590005857	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590005858	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590005859	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590005860	putative active site [active]
435590005861	putative NTP binding site [chemical binding]; other site
435590005862	putative nucleic acid binding site [nucleotide binding]; other site
435590005863	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590005864	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590005865	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590005866	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590005867	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590005868	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590005869	putative active site [active]
435590005870	putative NTP binding site [chemical binding]; other site
435590005871	putative nucleic acid binding site [nucleotide binding]; other site
435590005872	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590005873	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590005874	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590005875	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590005876	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590005877	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590005878	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590005879	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590005880	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590005881	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590005882	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590005883	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590005884	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590005885	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590005886	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
435590005887	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
435590005888	ParB-like nuclease domain; Region: ParBc; pfam02195
435590005889	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005890	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005891	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005893	dimer interface [polypeptide binding]; other site
435590005894	phosphorylation site [posttranslational modification]
435590005895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005896	ATP binding site [chemical binding]; other site
435590005897	G-X-G motif; other site
435590005898	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005900	active site
435590005901	phosphorylation site [posttranslational modification]
435590005902	intermolecular recognition site; other site
435590005903	dimerization interface [polypeptide binding]; other site
435590005904	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590005905	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005906	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005907	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005908	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590005909	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005910	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005911	SusD family; Region: SusD; pfam07980
435590005912	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590005913	active site
435590005914	catalytic triad [active]
435590005915	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
435590005916	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
435590005917	putative active site [active]
435590005918	putative metal binding site [ion binding]; other site
435590005919	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
435590005920	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
435590005921	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590005922	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590005923	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590005924	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005925	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590005926	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005927	Two component regulator propeller; Region: Reg_prop; pfam07494
435590005928	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005929	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005931	dimer interface [polypeptide binding]; other site
435590005932	phosphorylation site [posttranslational modification]
435590005933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005934	ATP binding site [chemical binding]; other site
435590005935	G-X-G motif; other site
435590005936	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590005937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005938	active site
435590005939	phosphorylation site [posttranslational modification]
435590005940	intermolecular recognition site; other site
435590005941	dimerization interface [polypeptide binding]; other site
435590005942	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005944	The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843
435590005945	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005946	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590005947	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590005948	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590005949	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590005950	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590005951	SusD family; Region: SusD; pfam07980
435590005952	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590005953	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005954	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590005955	active site
435590005956	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590005957	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590005958	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590005959	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590005960	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590005961	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590005962	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590005963	mannonate dehydratase; Region: uxuA; TIGR00695
435590005964	mannonate dehydratase; Provisional; Region: PRK03906
435590005965	D-mannonate oxidoreductase; Provisional; Region: PRK08277
435590005966	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
435590005967	putative NAD(P) binding site [chemical binding]; other site
435590005968	active site
435590005969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005970	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
435590005971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005972	ATP binding site [chemical binding]; other site
435590005973	Mg2+ binding site [ion binding]; other site
435590005974	G-X-G motif; other site
435590005975	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005977	active site
435590005978	phosphorylation site [posttranslational modification]
435590005979	intermolecular recognition site; other site
435590005980	dimerization interface [polypeptide binding]; other site
435590005981	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590005982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005983	active site
435590005984	phosphorylation site [posttranslational modification]
435590005985	intermolecular recognition site; other site
435590005986	dimerization interface [polypeptide binding]; other site
435590005987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590005988	Walker A motif; other site
435590005989	ATP binding site [chemical binding]; other site
435590005990	Walker B motif; other site
435590005991	arginine finger; other site
435590005992	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590005993	RteC protein; Region: RteC; pfam09357
435590005994	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590005995	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590005996	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
435590005997	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590005998	ligand binding site [chemical binding]; other site
435590005999	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590006000	Lipocalin-like domain; Region: Lipocalin_6; pfam13944
435590006001	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
435590006002	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006003	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590006004	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590006005	N-terminal plug; other site
435590006006	ligand-binding site [chemical binding]; other site
435590006007	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
435590006008	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
435590006009	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
435590006010	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
435590006011	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590006012	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
435590006013	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
435590006014	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590006015	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006016	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006017	catalytic residues [active]
435590006018	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
435590006019	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
435590006020	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590006021	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006022	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590006023	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006024	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006025	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006026	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590006027	FecR protein; Region: FecR; pfam04773
435590006028	Phosphoglycerate kinase; Region: PGK; pfam00162
435590006029	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
435590006030	substrate binding site [chemical binding]; other site
435590006031	hinge regions; other site
435590006032	ADP binding site [chemical binding]; other site
435590006033	catalytic site [active]
435590006034	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
435590006035	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
435590006036	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590006037	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590006038	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590006039	active site
435590006040	Fn3 associated; Region: Fn3_assoc; pfam13287
435590006041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
435590006042	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590006043	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006044	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006045	DNA binding residues [nucleotide binding]
435590006046	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
435590006047	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
435590006048	putative efflux protein, MATE family; Region: matE; TIGR00797
435590006049	signal recognition particle protein; Provisional; Region: PRK10867
435590006050	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
435590006051	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
435590006052	P loop; other site
435590006053	GTP binding site [chemical binding]; other site
435590006054	Signal peptide binding domain; Region: SRP_SPB; pfam02978
435590006055	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
435590006056	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
435590006057	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
435590006058	homodimer interface [polypeptide binding]; other site
435590006059	NADP binding site [chemical binding]; other site
435590006060	substrate binding site [chemical binding]; other site
435590006061	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
435590006062	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
435590006063	putative active site [active]
435590006064	putative metal binding site [ion binding]; other site
435590006065	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590006066	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006068	DNA binding residues [nucleotide binding]
435590006069	FecR protein; Region: FecR; pfam04773
435590006070	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006071	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006072	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006073	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006074	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590006075	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590006076	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006077	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006078	catalytic residues [active]
435590006079	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590006080	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006081	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006082	catalytic residues [active]
435590006083	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590006084	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590006085	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590006086	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590006087	active site
435590006088	catalytic residues [active]
435590006089	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590006090	Two component regulator propeller; Region: Reg_prop; pfam07494
435590006091	Two component regulator propeller; Region: Reg_prop; pfam07494
435590006092	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590006093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590006094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590006095	dimer interface [polypeptide binding]; other site
435590006096	phosphorylation site [posttranslational modification]
435590006097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590006098	ATP binding site [chemical binding]; other site
435590006099	Mg2+ binding site [ion binding]; other site
435590006100	G-X-G motif; other site
435590006101	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590006102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590006103	active site
435590006104	phosphorylation site [posttranslational modification]
435590006105	intermolecular recognition site; other site
435590006106	dimerization interface [polypeptide binding]; other site
435590006107	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590006108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590006109	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006110	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006111	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006112	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590006113	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590006114	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590006115	SusD family; Region: SusD; pfam07980
435590006116	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590006117	active site
435590006118	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
435590006119	active site
435590006120	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
435590006121	putative substrate binding site [chemical binding]; other site
435590006122	active site
435590006123	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
435590006124	active site
435590006125	para-aminobenzoate synthase component I; Validated; Region: PRK07093
435590006126	hypothetical protein; Provisional; Region: PRK07101
435590006127	substrate-cofactor binding pocket; other site
435590006128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590006129	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590006130	putative substrate translocation pore; other site
435590006131	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
435590006132	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
435590006133	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
435590006134	dimer interface [polypeptide binding]; other site
435590006135	motif 1; other site
435590006136	active site
435590006137	motif 2; other site
435590006138	motif 3; other site
435590006139	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
435590006140	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
435590006141	FAD binding domain; Region: FAD_binding_4; pfam01565
435590006142	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
435590006143	putative hydrolase; Provisional; Region: PRK02113
435590006144	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
435590006145	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
435590006146	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
435590006147	minor groove reading motif; other site
435590006148	helix-hairpin-helix signature motif; other site
435590006149	substrate binding pocket [chemical binding]; other site
435590006150	active site
435590006151	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
435590006152	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
435590006153	Amidinotransferase; Region: Amidinotransf; cl12043
435590006154	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
435590006155	Amidinotransferase; Region: Amidinotransf; pfam02274
435590006156	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
435590006157	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
435590006158	inhibitor-cofactor binding pocket; inhibition site
435590006159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590006160	catalytic residue [active]
435590006161	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
435590006162	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
435590006163	Ligand Binding Site [chemical binding]; other site
435590006164	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
435590006165	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
435590006166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590006167	Walker A motif; other site
435590006168	ATP binding site [chemical binding]; other site
435590006169	DNA polymerase III subunit delta'; Validated; Region: PRK08485
435590006170	Walker B motif; other site
435590006171	arginine finger; other site
435590006172	Septum formation initiator; Region: DivIC; cl17659
435590006173	Peptidase S46; Region: Peptidase_S46; pfam10459
435590006174	Peptidase S46; Region: Peptidase_S46; pfam10459
435590006175	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590006176	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590006177	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590006178	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
435590006179	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
435590006180	putative acyl-acceptor binding pocket; other site
435590006181	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
435590006182	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590006183	putative active site [active]
435590006184	putative metal binding site [ion binding]; other site
435590006185	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
435590006186	dihydroorotase; Reviewed; Region: PRK09236
435590006187	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590006188	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
435590006189	active site
435590006190	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
435590006191	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
435590006192	Ligand binding site; other site
435590006193	Putative Catalytic site; other site
435590006194	DXD motif; other site
435590006195	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590006196	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
435590006197	NlpE N-terminal domain; Region: NlpE; pfam04170
435590006198	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590006199	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
435590006200	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
435590006201	Catalytic dyad [active]
435590006202	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
435590006203	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590006204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590006205	homodimer interface [polypeptide binding]; other site
435590006206	catalytic residue [active]
435590006207	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
435590006208	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590006209	TrkA-C domain; Region: TrkA_C; pfam02080
435590006210	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590006211	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
435590006212	Transposase domain (DUF772); Region: DUF772; pfam05598
435590006213	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590006214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590006215	TPR motif; other site
435590006216	TPR repeat; Region: TPR_11; pfam13414
435590006217	binding surface
435590006218	TPR repeat; Region: TPR_11; pfam13414
435590006219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590006220	binding surface
435590006221	TPR motif; other site
435590006222	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590006223	Predicted membrane protein [Function unknown]; Region: COG2311
435590006224	Protein of unknown function (DUF418); Region: DUF418; cl12135
435590006225	Protein of unknown function (DUF418); Region: DUF418; pfam04235
435590006226	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
435590006227	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
435590006228	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590006229	ATP binding site [chemical binding]; other site
435590006230	putative Mg++ binding site [ion binding]; other site
435590006231	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590006232	nucleotide binding region [chemical binding]; other site
435590006233	ATP-binding site [chemical binding]; other site
435590006234	TRCF domain; Region: TRCF; pfam03461
435590006235	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590006236	C-N hydrolase family amidase; Provisional; Region: PRK10438
435590006237	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
435590006238	putative active site [active]
435590006239	catalytic triad [active]
435590006240	dimer interface [polypeptide binding]; other site
435590006241	multimer interface [polypeptide binding]; other site
435590006242	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
435590006243	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590006244	dimer interface [polypeptide binding]; other site
435590006245	PYR/PP interface [polypeptide binding]; other site
435590006246	TPP binding site [chemical binding]; other site
435590006247	substrate binding site [chemical binding]; other site
435590006248	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
435590006249	TPP-binding site; other site
435590006250	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
435590006251	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
435590006252	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590006253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590006254	homodimer interface [polypeptide binding]; other site
435590006255	catalytic residue [active]
435590006256	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
435590006257	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590006258	acyl-activating enzyme (AAE) consensus motif; other site
435590006259	AMP binding site [chemical binding]; other site
435590006260	active site
435590006261	CoA binding site [chemical binding]; other site
435590006262	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
435590006263	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
435590006264	SWIM zinc finger; Region: SWIM; pfam04434
435590006265	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
435590006266	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
435590006267	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
435590006268	hypothetical protein; Provisional; Region: PRK00955
435590006269	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
435590006270	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
435590006271	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
435590006272	Interdomain contacts; other site
435590006273	Cytokine receptor motif; other site
435590006274	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
435590006275	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
435590006276	putative acyl-acceptor binding pocket; other site
435590006277	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
435590006278	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
435590006279	active site
435590006280	ADP/pyrophosphate binding site [chemical binding]; other site
435590006281	dimerization interface [polypeptide binding]; other site
435590006282	allosteric effector site; other site
435590006283	fructose-1,6-bisphosphate binding site; other site
435590006284	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
435590006285	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
435590006286	active site
435590006287	hypothetical protein; Provisional; Region: PRK11770
435590006288	Domain of unknown function (DUF307); Region: DUF307; pfam03733
435590006289	Domain of unknown function (DUF307); Region: DUF307; pfam03733
435590006290	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
435590006291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590006292	S-adenosylmethionine binding site [chemical binding]; other site
435590006293	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006294	catalytic residues [active]
435590006295	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590006296	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
435590006297	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
435590006298	catalytic residues [active]
435590006299	catalytic nucleophile [active]
435590006300	Recombinase; Region: Recombinase; pfam07508
435590006301	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
435590006302	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590006303	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590006304	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590006305	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590006306	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006307	active site
435590006308	DNA binding site [nucleotide binding]
435590006309	Int/Topo IB signature motif; other site
435590006310	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
435590006311	VirE N-terminal domain; Region: VirE_N; pfam08800
435590006312	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590006313	Domain of unknown function (DUF4421); Region: DUF4421; pfam14391
435590006314	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590006315	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
435590006316	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
435590006317	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
435590006318	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
435590006319	substrate binding pocket [chemical binding]; other site
435590006320	membrane-bound complex binding site; other site
435590006321	hinge residues; other site
435590006322	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
435590006323	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
435590006324	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
435590006325	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
435590006326	TPP-binding site [chemical binding]; other site
435590006327	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
435590006328	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590006329	dimer interface [polypeptide binding]; other site
435590006330	PYR/PP interface [polypeptide binding]; other site
435590006331	TPP binding site [chemical binding]; other site
435590006332	substrate binding site [chemical binding]; other site
435590006333	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590006334	Ferredoxin [Energy production and conversion]; Region: COG1146
435590006335	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590006336	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590006337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590006338	TPR motif; other site
435590006339	binding surface
435590006340	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
435590006341	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
435590006342	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
435590006343	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
435590006344	TPP-binding site [chemical binding]; other site
435590006345	dimer interface [polypeptide binding]; other site
435590006346	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590006347	PYR/PP interface [polypeptide binding]; other site
435590006348	dimer interface [polypeptide binding]; other site
435590006349	TPP binding site [chemical binding]; other site
435590006350	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590006351	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
435590006352	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
435590006353	putative N- and C-terminal domain interface [polypeptide binding]; other site
435590006354	putative active site [active]
435590006355	MgATP binding site [chemical binding]; other site
435590006356	catalytic site [active]
435590006357	metal binding site [ion binding]; metal-binding site
435590006358	putative carbohydrate binding site [chemical binding]; other site
435590006359	L-arabinose isomerase; Provisional; Region: PRK02929
435590006360	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
435590006361	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590006362	trimer interface [polypeptide binding]; other site
435590006363	substrate binding site [chemical binding]; other site
435590006364	Mn binding site [ion binding]; other site
435590006365	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
435590006366	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
435590006367	intersubunit interface [polypeptide binding]; other site
435590006368	active site
435590006369	Zn2+ binding site [ion binding]; other site
435590006370	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
435590006371	nudix motif; other site
435590006372	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
435590006373	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
435590006374	Na binding site [ion binding]; other site
435590006375	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590006376	active site
435590006377	catalytic residues [active]
435590006378	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
435590006379	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
435590006380	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
435590006381	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
435590006382	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590006383	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590006384	active site
435590006385	catalytic residues [active]
435590006386	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
435590006387	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590006388	chaperone protein DnaJ; Provisional; Region: PRK14289
435590006389	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590006390	HSP70 interaction site [polypeptide binding]; other site
435590006391	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
435590006392	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
435590006393	dimer interface [polypeptide binding]; other site
435590006394	GrpE; Region: GrpE; pfam01025
435590006395	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
435590006396	dimer interface [polypeptide binding]; other site
435590006397	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
435590006398	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
435590006399	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590006400	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590006401	ABC transporter; Region: ABC_tran_2; pfam12848
435590006402	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590006403	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590006404	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590006405	active site
435590006406	catalytic triad [active]
435590006407	oxyanion hole [active]
435590006408	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
435590006409	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
435590006410	active site
435590006411	catalytic motif [active]
435590006412	Zn binding site [ion binding]; other site
435590006413	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
435590006414	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
435590006415	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590006416	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006417	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006418	DNA binding residues [nucleotide binding]
435590006419	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
435590006420	putative ligand binding site [chemical binding]; other site
435590006421	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
435590006422	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590006423	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590006424	HlyD family secretion protein; Region: HlyD_2; pfam12700
435590006425	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590006426	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006427	FtsX-like permease family; Region: FtsX; pfam02687
435590006428	FtsX-like permease family; Region: FtsX; pfam02687
435590006429	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590006430	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590006431	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590006432	Walker A/P-loop; other site
435590006433	ATP binding site [chemical binding]; other site
435590006434	Q-loop/lid; other site
435590006435	ABC transporter signature motif; other site
435590006436	Walker B; other site
435590006437	D-loop; other site
435590006438	H-loop/switch region; other site
435590006439	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006440	FtsX-like permease family; Region: FtsX; pfam02687
435590006441	FtsX-like permease family; Region: FtsX; pfam02687
435590006442	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590006443	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006444	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590006445	FtsX-like permease family; Region: FtsX; pfam02687
435590006446	FtsX-like permease family; Region: FtsX; pfam02687
435590006447	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006448	FtsX-like permease family; Region: FtsX; pfam02687
435590006449	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006450	FtsX-like permease family; Region: FtsX; pfam02687
435590006451	Outer membrane efflux protein; Region: OEP; pfam02321
435590006452	Outer membrane efflux protein; Region: OEP; pfam02321
435590006453	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590006454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590006455	active site
435590006456	phosphorylation site [posttranslational modification]
435590006457	intermolecular recognition site; other site
435590006458	dimerization interface [polypeptide binding]; other site
435590006459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590006460	Walker A motif; other site
435590006461	ATP binding site [chemical binding]; other site
435590006462	Walker B motif; other site
435590006463	arginine finger; other site
435590006464	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590006465	HAMP domain; Region: HAMP; pfam00672
435590006466	dimerization interface [polypeptide binding]; other site
435590006467	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
435590006468	PAS domain; Region: PAS; smart00091
435590006469	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
435590006470	putative active site [active]
435590006471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590006472	ATP binding site [chemical binding]; other site
435590006473	Mg2+ binding site [ion binding]; other site
435590006474	G-X-G motif; other site
435590006475	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
435590006476	substrate binding pocket [chemical binding]; other site
435590006477	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
435590006478	membrane-bound complex binding site; other site
435590006479	hinge residues; other site
435590006480	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
435590006481	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
435590006482	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590006483	catalytic residue [active]
435590006484	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
435590006485	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
435590006486	Sugar specificity; other site
435590006487	Pyrimidine base specificity; other site
435590006488	ATP-binding site [chemical binding]; other site
435590006489	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
435590006490	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590006491	CoenzymeA binding site [chemical binding]; other site
435590006492	subunit interaction site [polypeptide binding]; other site
435590006493	PHB binding site; other site
435590006494	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
435590006495	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
435590006496	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
435590006497	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
435590006498	histidinol dehydrogenase; Region: hisD; TIGR00069
435590006499	NAD binding site [chemical binding]; other site
435590006500	dimerization interface [polypeptide binding]; other site
435590006501	product binding site; other site
435590006502	substrate binding site [chemical binding]; other site
435590006503	zinc binding site [ion binding]; other site
435590006504	catalytic residues [active]
435590006505	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
435590006506	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590006507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590006508	homodimer interface [polypeptide binding]; other site
435590006509	catalytic residue [active]
435590006510	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
435590006511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590006512	active site
435590006513	motif I; other site
435590006514	motif II; other site
435590006515	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
435590006516	putative active site pocket [active]
435590006517	4-fold oligomerization interface [polypeptide binding]; other site
435590006518	metal binding residues [ion binding]; metal-binding site
435590006519	3-fold/trimer interface [polypeptide binding]; other site
435590006520	NAD synthetase; Reviewed; Region: nadE; PRK02628
435590006521	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
435590006522	multimer interface [polypeptide binding]; other site
435590006523	active site
435590006524	catalytic triad [active]
435590006525	protein interface 1 [polypeptide binding]; other site
435590006526	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
435590006527	homodimer interface [polypeptide binding]; other site
435590006528	NAD binding pocket [chemical binding]; other site
435590006529	ATP binding pocket [chemical binding]; other site
435590006530	Mg binding site [ion binding]; other site
435590006531	active-site loop [active]
435590006532	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
435590006533	metal binding site 2 [ion binding]; metal-binding site
435590006534	putative DNA binding helix; other site
435590006535	metal binding site 1 [ion binding]; metal-binding site
435590006536	dimer interface [polypeptide binding]; other site
435590006537	structural Zn2+ binding site [ion binding]; other site
435590006538	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
435590006539	Rubredoxin; Region: Rubredoxin; pfam00301
435590006540	iron binding site [ion binding]; other site
435590006541	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
435590006542	Rubrerythrin [Energy production and conversion]; Region: COG1592
435590006543	diiron binding motif [ion binding]; other site
435590006544	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006545	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006546	catalytic residues [active]
435590006547	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006548	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006549	catalytic residues [active]
435590006550	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
435590006551	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
435590006552	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
435590006553	metal binding site [ion binding]; metal-binding site
435590006554	dimer interface [polypeptide binding]; other site
435590006555	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590006556	putative catalytic site [active]
435590006557	putative metal binding site [ion binding]; other site
435590006558	putative phosphate binding site [ion binding]; other site
435590006559	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
435590006560	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
435590006561	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
435590006562	dimerization interface [polypeptide binding]; other site
435590006563	active site
435590006564	recombinase A; Provisional; Region: recA; PRK09354
435590006565	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
435590006566	hexamer interface [polypeptide binding]; other site
435590006567	Walker A motif; other site
435590006568	ATP binding site [chemical binding]; other site
435590006569	Walker B motif; other site
435590006570	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
435590006571	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
435590006572	catalytic triad [active]
435590006573	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
435590006574	META domain; Region: META; pfam03724
435590006575	META domain; Region: META; pfam03724
435590006576	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
435590006577	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
435590006578	nucleotide binding site [chemical binding]; other site
435590006579	NEF interaction site [polypeptide binding]; other site
435590006580	SBD interface [polypeptide binding]; other site
435590006581	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
435590006582	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590006583	Divergent AAA domain; Region: AAA_4; pfam04326
435590006584	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590006585	HTH domain; Region: HTH_11; pfam08279
435590006586	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006587	active site
435590006588	DNA binding site [nucleotide binding]
435590006589	Int/Topo IB signature motif; other site
435590006590	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
435590006591	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590006592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
435590006593	motif I; other site
435590006594	active site
435590006595	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590006596	SLBB domain; Region: SLBB; pfam10531
435590006597	Chain length determinant protein; Region: Wzz; pfam02706
435590006598	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
435590006599	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590006600	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590006601	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590006602	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590006603	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
435590006604	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
435590006605	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590006606	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
435590006607	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
435590006608	active site
435590006609	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006610	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
435590006611	putative ADP-binding pocket [chemical binding]; other site
435590006612	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590006613	4Fe-4S binding domain; Region: Fer4_6; pfam12837
435590006614	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
435590006615	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590006616	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
435590006617	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006618	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
435590006619	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006620	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
435590006621	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590006622	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
435590006623	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
435590006624	substrate binding site; other site
435590006625	tetramer interface; other site
435590006626	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
435590006627	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
435590006628	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
435590006629	NADP binding site [chemical binding]; other site
435590006630	active site
435590006631	putative substrate binding site [chemical binding]; other site
435590006632	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
435590006633	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
435590006634	NAD binding site [chemical binding]; other site
435590006635	substrate binding site [chemical binding]; other site
435590006636	homodimer interface [polypeptide binding]; other site
435590006637	active site
435590006638	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
435590006639	Bacterial sugar transferase; Region: Bac_transf; pfam02397
435590006640	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590006641	amidase catalytic site [active]
435590006642	Zn binding residues [ion binding]; other site
435590006643	substrate binding site [chemical binding]; other site
435590006644	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590006645	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
435590006646	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590006647	VirE N-terminal domain; Region: VirE_N; pfam08800
435590006648	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
435590006649	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590006650	ATP binding site [chemical binding]; other site
435590006651	putative Mg++ binding site [ion binding]; other site
435590006652	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590006653	nucleotide binding region [chemical binding]; other site
435590006654	ATP-binding site [chemical binding]; other site
435590006655	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
435590006656	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590006657	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
435590006658	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590006659	acyl-activating enzyme (AAE) consensus motif; other site
435590006660	AMP binding site [chemical binding]; other site
435590006661	active site
435590006662	CoA binding site [chemical binding]; other site
435590006663	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
435590006664	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
435590006665	active site
435590006666	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
435590006667	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
435590006668	substrate binding site [chemical binding]; other site
435590006669	oxyanion hole (OAH) forming residues; other site
435590006670	trimer interface [polypeptide binding]; other site
435590006671	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
435590006672	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
435590006673	dimer interface [polypeptide binding]; other site
435590006674	tetramer interface [polypeptide binding]; other site
435590006675	PYR/PP interface [polypeptide binding]; other site
435590006676	TPP binding site [chemical binding]; other site
435590006677	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
435590006678	TPP-binding site; other site
435590006679	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
435590006680	chorismate binding enzyme; Region: Chorismate_bind; cl10555
435590006681	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590006682	CoenzymeA binding site [chemical binding]; other site
435590006683	subunit interaction site [polypeptide binding]; other site
435590006684	PHB binding site; other site
435590006685	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590006686	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
435590006687	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
435590006688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
435590006689	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590006690	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
435590006691	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
435590006692	active site residue [active]
435590006693	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
435590006694	CPxP  motif; other site
435590006695	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
435590006696	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
435590006697	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
435590006698	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
435590006699	Cl- selectivity filter; other site
435590006700	Cl- binding residues [ion binding]; other site
435590006701	pore gating glutamate residue; other site
435590006702	dimer interface [polypeptide binding]; other site
435590006703	H+/Cl- coupling transport residue; other site
435590006704	TrkA-C domain; Region: TrkA_C; pfam02080
435590006705	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
435590006706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590006707	TPR motif; other site
435590006708	binding surface
435590006709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590006710	binding surface
435590006711	TPR motif; other site
435590006712	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590006713	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590006714	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590006715	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006716	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006717	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590006718	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006719	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590006720	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006721	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590006722	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006723	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006724	catalytic residues [active]
435590006725	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590006726	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006727	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006728	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006729	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006730	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006731	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
435590006732	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590006733	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006734	endonuclease IV; Provisional; Region: PRK01060
435590006735	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
435590006736	AP (apurinic/apyrimidinic) site pocket; other site
435590006737	DNA interaction; other site
435590006738	Metal-binding active site; metal-binding site
435590006739	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
435590006740	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
435590006741	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
435590006742	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590006743	catalytic residue [active]
435590006744	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
435590006745	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
435590006746	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
435590006747	TrkA-N domain; Region: TrkA_N; pfam02254
435590006748	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590006749	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590006750	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
435590006751	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
435590006752	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
435590006753	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590006754	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
435590006755	active site
435590006756	metal binding site [ion binding]; metal-binding site
435590006757	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590006758	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006759	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590006760	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006761	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006762	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006763	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006764	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006765	FecR protein; Region: FecR; pfam04773
435590006766	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
435590006767	DNA binding residues [nucleotide binding]
435590006768	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
435590006769	MutS domain III; Region: MutS_III; pfam05192
435590006770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590006771	Walker A/P-loop; other site
435590006772	ATP binding site [chemical binding]; other site
435590006773	Q-loop/lid; other site
435590006774	ABC transporter signature motif; other site
435590006775	Walker B; other site
435590006776	D-loop; other site
435590006777	H-loop/switch region; other site
435590006778	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
435590006779	Smr domain; Region: Smr; pfam01713
435590006780	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590006781	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590006782	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590006783	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
435590006784	CHC2 zinc finger; Region: zf-CHC2; cl17510
435590006785	Toprim-like; Region: Toprim_2; pfam13155
435590006786	active site
435590006787	metal binding site [ion binding]; metal-binding site
435590006788	AAA domain; Region: AAA_25; pfam13481
435590006789	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
435590006790	ATP binding site [chemical binding]; other site
435590006791	Walker B motif; other site
435590006792	Protein of unknown function (DUF3853); Region: DUF3853; pfam12964
435590006793	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006794	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590006795	active site
435590006796	DNA binding site [nucleotide binding]
435590006797	Int/Topo IB signature motif; other site
435590006798	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590006799	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590006800	Int/Topo IB signature motif; other site
435590006801	ORF6N domain; Region: ORF6N; pfam10543
435590006802	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590006803	MPN+ (JAMM) motif; other site
435590006804	Zinc-binding site [ion binding]; other site
435590006805	Antirestriction protein (ArdA); Region: ArdA; pfam07275
435590006806	AAA ATPase domain; Region: AAA_15; pfam13175
435590006807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590006808	Walker A/P-loop; other site
435590006809	ATP binding site [chemical binding]; other site
435590006810	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590006811	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
435590006812	active site
435590006813	metal binding site [ion binding]; metal-binding site
435590006814	interdomain interaction site; other site
435590006815	AAA domain; Region: AAA_25; pfam13481
435590006816	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590006817	Bacterial PH domain; Region: DUF304; pfam03703
435590006818	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590006819	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590006820	ligand binding site [chemical binding]; other site
435590006821	flexible hinge region; other site
435590006822	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
435590006823	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
435590006824	metal binding site 2 [ion binding]; metal-binding site
435590006825	putative DNA binding helix; other site
435590006826	metal binding site 1 [ion binding]; metal-binding site
435590006827	dimer interface [polypeptide binding]; other site
435590006828	structural Zn2+ binding site [ion binding]; other site
435590006829	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
435590006830	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590006831	Soluble P-type ATPase [General function prediction only]; Region: COG4087
435590006832	Predicted esterase [General function prediction only]; Region: COG0627
435590006833	S-formylglutathione hydrolase; Region: PLN02442
435590006834	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
435590006835	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
435590006836	putative NAD(P) binding site [chemical binding]; other site
435590006837	homodimer interface [polypeptide binding]; other site
435590006838	homotetramer interface [polypeptide binding]; other site
435590006839	active site
435590006840	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
435590006841	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
435590006842	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590006843	carboxyltransferase (CT) interaction site; other site
435590006844	biotinylation site [posttranslational modification]; other site
435590006845	Lamin Tail Domain; Region: LTD; pfam00932
435590006846	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590006847	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
435590006848	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
435590006849	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590006850	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
435590006851	dimer interface [polypeptide binding]; other site
435590006852	substrate binding site [chemical binding]; other site
435590006853	metal binding site [ion binding]; metal-binding site
435590006854	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
435590006855	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
435590006856	FMN binding site [chemical binding]; other site
435590006857	dimer interface [polypeptide binding]; other site
435590006858	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
435590006859	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
435590006860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590006861	active site
435590006862	motif I; other site
435590006863	motif II; other site
435590006864	Maf-like protein; Region: Maf; pfam02545
435590006865	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
435590006866	active site
435590006867	dimer interface [polypeptide binding]; other site
435590006868	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
435590006869	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
435590006870	putative ligand binding site [chemical binding]; other site
435590006871	putative NAD binding site [chemical binding]; other site
435590006872	catalytic site [active]
435590006873	Protein of unknown function (DUF3843); Region: DUF3843; pfam12954
435590006874	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
435590006875	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
435590006876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590006877	putative substrate translocation pore; other site
435590006878	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006879	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006880	catalytic residues [active]
435590006881	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006882	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006883	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
435590006884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
435590006885	Protein of unknown function (DUF1699); Region: DUF1699; pfam08004
435590006886	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
435590006887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590006888	Walker A/P-loop; other site
435590006889	ATP binding site [chemical binding]; other site
435590006890	Q-loop/lid; other site
435590006891	ABC transporter signature motif; other site
435590006892	Walker B; other site
435590006893	D-loop; other site
435590006894	H-loop/switch region; other site
435590006895	GGGtGRT protein; Region: GGGtGRT; pfam14057
435590006896	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
435590006897	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
435590006898	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
435590006899	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
435590006900	NigD-like protein; Region: NigD; pfam12667
435590006901	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590006902	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590006903	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590006904	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590006905	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006906	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
435590006907	active site
435590006908	catalytic residues [active]
435590006909	DNA binding site [nucleotide binding]
435590006910	Int/Topo IB signature motif; other site
435590006911	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
435590006912	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
435590006913	SmpB-tmRNA interface; other site
435590006914	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
435590006915	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
435590006916	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
435590006917	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
435590006918	substrate binding pocket [chemical binding]; other site
435590006919	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
435590006920	B12 binding site [chemical binding]; other site
435590006921	cobalt ligand [ion binding]; other site
435590006922	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
435590006923	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
435590006924	Substrate binding site; other site
435590006925	metal-binding site
435590006926	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
435590006927	Phosphotransferase enzyme family; Region: APH; pfam01636
435590006928	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
435590006929	xanthine permease; Region: pbuX; TIGR03173
435590006930	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590006931	active site
435590006932	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
435590006933	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
435590006934	putative FMN binding site [chemical binding]; other site
435590006935	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
435590006936	hypothetical protein; Validated; Region: PRK09104
435590006937	metal binding site [ion binding]; metal-binding site
435590006938	putative dimer interface [polypeptide binding]; other site
435590006939	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
435590006940	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
435590006941	Tetramer interface [polypeptide binding]; other site
435590006942	active site
435590006943	FMN-binding site [chemical binding]; other site
435590006944	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
435590006945	Repair protein; Region: Repair_PSII; pfam04536
435590006946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
435590006947	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590006948	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
435590006949	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
435590006950	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
435590006951	shikimate binding site; other site
435590006952	NAD(P) binding site [chemical binding]; other site
435590006953	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
435590006954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590006955	S-adenosylmethionine binding site [chemical binding]; other site
435590006956	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
435590006957	ATP binding site [chemical binding]; other site
435590006958	active site
435590006959	substrate binding site [chemical binding]; other site
435590006960	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
435590006961	PhoH-like protein; Region: PhoH; pfam02562
435590006962	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
435590006963	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
435590006964	dimerization interface 3.5A [polypeptide binding]; other site
435590006965	active site
435590006966	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
435590006967	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
435590006968	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590006969	FeS/SAM binding site; other site
435590006970	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006971	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590006972	catalytic residues [active]
435590006973	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006974	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590006975	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590006976	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590006977	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590006978	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590006979	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006980	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
435590006981	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
435590006982	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
435590006983	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
435590006984	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
435590006985	PYR/PP interface [polypeptide binding]; other site
435590006986	dimer interface [polypeptide binding]; other site
435590006987	TPP binding site [chemical binding]; other site
435590006988	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
435590006989	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
435590006990	TPP-binding site [chemical binding]; other site
435590006991	dimer interface [polypeptide binding]; other site
435590006992	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
435590006993	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590006994	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
435590006995	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590006996	active site
435590006997	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590006998	active site 2 [active]
435590006999	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
435590007000	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
435590007001	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
435590007002	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590007003	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590007004	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590007005	SurA N-terminal domain; Region: SurA_N_2; pfam13623
435590007006	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
435590007007	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
435590007008	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590007009	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590007010	Transporter associated domain; Region: CorC_HlyC; smart01091
435590007011	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
435590007012	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590007013	binding surface
435590007014	TPR motif; other site
435590007015	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
435590007016	pantothenate kinase; Reviewed; Region: PRK13320
435590007017	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
435590007018	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
435590007019	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
435590007020	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
435590007021	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007022	nucleotide binding region [chemical binding]; other site
435590007023	ATP-binding site [chemical binding]; other site
435590007024	SEC-C motif; Region: SEC-C; pfam02810
435590007025	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590007026	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007027	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007028	DNA binding residues [nucleotide binding]
435590007029	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
435590007030	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590007031	active site
435590007032	HIGH motif; other site
435590007033	nucleotide binding site [chemical binding]; other site
435590007034	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
435590007035	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
435590007036	active site
435590007037	KMSKS motif; other site
435590007038	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
435590007039	tRNA binding surface [nucleotide binding]; other site
435590007040	anticodon binding site; other site
435590007041	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
435590007042	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
435590007043	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
435590007044	homodimer interface [polypeptide binding]; other site
435590007045	metal binding site [ion binding]; metal-binding site
435590007046	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
435590007047	homodimer interface [polypeptide binding]; other site
435590007048	active site
435590007049	putative chemical substrate binding site [chemical binding]; other site
435590007050	metal binding site [ion binding]; metal-binding site
435590007051	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007052	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007053	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007054	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007055	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
435590007056	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
435590007057	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007059	DNA binding residues [nucleotide binding]
435590007060	ribonuclease Z; Region: RNase_Z; TIGR02651
435590007061	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
435590007062	DNA-binding site [nucleotide binding]; DNA binding site
435590007063	RNA-binding motif; other site
435590007064	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
435590007065	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
435590007066	RNA binding site [nucleotide binding]; other site
435590007067	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
435590007068	RNA binding site [nucleotide binding]; other site
435590007069	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
435590007070	RNA binding site [nucleotide binding]; other site
435590007071	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590007072	RNA binding site [nucleotide binding]; other site
435590007073	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590007074	RNA binding site [nucleotide binding]; other site
435590007075	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
435590007076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
435590007077	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
435590007078	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
435590007079	putative active site [active]
435590007080	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
435590007081	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590007082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007083	active site
435590007084	phosphorylation site [posttranslational modification]
435590007085	intermolecular recognition site; other site
435590007086	dimerization interface [polypeptide binding]; other site
435590007087	LytTr DNA-binding domain; Region: LytTR; smart00850
435590007088	Histidine kinase; Region: His_kinase; pfam06580
435590007089	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590007090	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
435590007091	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590007092	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590007093	muropeptide transporter; Reviewed; Region: ampG; PRK11902
435590007094	muropeptide transporter; Validated; Region: ampG; cl17669
435590007095	Stage II sporulation protein; Region: SpoIID; pfam08486
435590007096	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
435590007097	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590007098	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590007099	active site
435590007100	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
435590007101	ATP adenylyltransferase; Region: ATP_transf; pfam09830
435590007102	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466
435590007103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590007104	FeS/SAM binding site; other site
435590007105	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
435590007106	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
435590007107	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
435590007108	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590007109	active site
435590007110	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
435590007111	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
435590007112	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
435590007113	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
435590007114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590007115	motif II; other site
435590007116	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590007117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590007118	putative substrate translocation pore; other site
435590007119	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590007120	Ribokinase-like subgroup D.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937
435590007121	substrate binding site [chemical binding]; other site
435590007122	ATP binding site [chemical binding]; other site
435590007123	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
435590007124	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
435590007125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590007126	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590007127	Walker A motif; other site
435590007128	ATP binding site [chemical binding]; other site
435590007129	Walker B motif; other site
435590007130	arginine finger; other site
435590007131	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590007132	Lipopolysaccharide-assembly; Region: LptE; cl01125
435590007133	Preprotein translocase SecG subunit; Region: SecG; pfam03840
435590007134	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
435590007135	active site
435590007136	putative catalytic site [active]
435590007137	DNA binding site [nucleotide binding]
435590007138	putative phosphate binding site [ion binding]; other site
435590007139	metal binding site A [ion binding]; metal-binding site
435590007140	AP binding site [nucleotide binding]; other site
435590007141	metal binding site B [ion binding]; metal-binding site
435590007142	Pirin-related protein [General function prediction only]; Region: COG1741
435590007143	Pirin; Region: Pirin; pfam02678
435590007144	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
435590007145	homopentamer interface [polypeptide binding]; other site
435590007146	active site
435590007147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590007148	TPR motif; other site
435590007149	binding surface
435590007150	recombination protein F; Reviewed; Region: recF; PRK00064
435590007151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590007152	Walker A/P-loop; other site
435590007153	ATP binding site [chemical binding]; other site
435590007154	Q-loop/lid; other site
435590007155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590007156	ABC transporter signature motif; other site
435590007157	Walker B; other site
435590007158	D-loop; other site
435590007159	H-loop/switch region; other site
435590007160	Protein of unknown function (DUF721); Region: DUF721; pfam05258
435590007161	Transposase domain (DUF772); Region: DUF772; pfam05598
435590007162	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590007163	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
435590007164	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
435590007165	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590007166	C-terminal peptidase (prc); Region: prc; TIGR00225
435590007167	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590007168	protein binding site [polypeptide binding]; other site
435590007169	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590007170	Catalytic dyad [active]
435590007171	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
435590007172	catalytic motif [active]
435590007173	Zn binding site [ion binding]; other site
435590007174	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590007175	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590007176	active site
435590007177	Zn binding site [ion binding]; other site
435590007178	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590007179	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590007180	ligand binding site [chemical binding]; other site
435590007181	flexible hinge region; other site
435590007182	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
435590007183	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
435590007184	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
435590007185	ApbE family; Region: ApbE; pfam02424
435590007186	Predicted membrane protein [Function unknown]; Region: COG1971
435590007187	Domain of unknown function DUF; Region: DUF204; pfam02659
435590007188	Domain of unknown function DUF; Region: DUF204; pfam02659
435590007189	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
435590007190	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
435590007191	Ligand binding site; other site
435590007192	Putative Catalytic site; other site
435590007193	DXD motif; other site
435590007194	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
435590007195	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
435590007196	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007197	ATP binding site [chemical binding]; other site
435590007198	putative Mg++ binding site [ion binding]; other site
435590007199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007200	nucleotide binding region [chemical binding]; other site
435590007201	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
435590007202	ATP-binding site [chemical binding]; other site
435590007203	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590007204	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590007205	enolase; Provisional; Region: eno; PRK00077
435590007206	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
435590007207	dimer interface [polypeptide binding]; other site
435590007208	metal binding site [ion binding]; metal-binding site
435590007209	substrate binding pocket [chemical binding]; other site
435590007210	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590007211	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590007212	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
435590007213	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
435590007214	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
435590007215	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
435590007216	BNR repeat-like domain; Region: BNR_2; pfam13088
435590007217	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590007218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590007219	Right handed beta helix region; Region: Beta_helix; pfam13229
435590007220	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
435590007221	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
435590007222	active site
435590007223	motif I; other site
435590007224	motif II; other site
435590007225	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590007226	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590007227	Substrate binding site; other site
435590007228	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
435590007229	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
435590007230	NADP binding site [chemical binding]; other site
435590007231	active site
435590007232	putative substrate binding site [chemical binding]; other site
435590007233	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
435590007234	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
435590007235	NADP-binding site; other site
435590007236	homotetramer interface [polypeptide binding]; other site
435590007237	substrate binding site [chemical binding]; other site
435590007238	homodimer interface [polypeptide binding]; other site
435590007239	active site
435590007240	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590007241	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590007242	metal-binding site
435590007243	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590007244	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
435590007245	putative metal binding site; other site
435590007246	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590007247	putative acyl transferase; Provisional; Region: PRK10502
435590007248	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
435590007249	putative trimer interface [polypeptide binding]; other site
435590007250	putative active site [active]
435590007251	putative substrate binding site [chemical binding]; other site
435590007252	putative CoA binding site [chemical binding]; other site
435590007253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590007254	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
435590007255	putative ADP-binding pocket [chemical binding]; other site
435590007256	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590007257	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590007258	substrate binding site [chemical binding]; other site
435590007259	ATP binding site [chemical binding]; other site
435590007260	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
435590007261	ligand binding site; other site
435590007262	tetramer interface; other site
435590007263	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
435590007264	active site
435590007265	catalytic residues [active]
435590007266	metal binding site [ion binding]; metal-binding site
435590007267	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590007268	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590007269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
435590007270	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
435590007271	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590007272	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590007273	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590007274	putative trimer interface [polypeptide binding]; other site
435590007275	putative CoA binding site [chemical binding]; other site
435590007276	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590007277	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590007278	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590007279	active site
435590007280	NTP binding site [chemical binding]; other site
435590007281	metal binding triad [ion binding]; metal-binding site
435590007282	antibiotic binding site [chemical binding]; other site
435590007283	Transcription antiterminator [Transcription]; Region: NusG; COG0250
435590007284	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590007285	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
435590007286	heterodimer interface [polypeptide binding]; other site
435590007287	homodimer interface [polypeptide binding]; other site
435590007288	VirE N-terminal domain; Region: VirE_N; pfam08800
435590007289	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590007290	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590007291	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590007292	amidase catalytic site [active]
435590007293	Zn binding residues [ion binding]; other site
435590007294	substrate binding site [chemical binding]; other site
435590007295	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
435590007296	Chain length determinant protein; Region: Wzz; pfam02706
435590007297	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
435590007298	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590007299	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590007300	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
435590007301	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590007302	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590007303	SLBB domain; Region: SLBB; pfam10531
435590007304	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
435590007305	Bacterial sugar transferase; Region: Bac_transf; pfam02397
435590007306	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007307	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590007308	active site
435590007309	DNA binding site [nucleotide binding]
435590007310	Int/Topo IB signature motif; other site
435590007311	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590007312	Major fimbrial subunit protein (FimA); Region: P_gingi_FimA; pfam06321
435590007313	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590007314	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590007315	OmpA family; Region: OmpA; pfam00691
435590007316	ligand binding site [chemical binding]; other site
435590007317	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590007318	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590007319	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590007320	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007321	active site
435590007322	DNA binding site [nucleotide binding]
435590007323	Int/Topo IB signature motif; other site
435590007324	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590007325	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590007326	active site
435590007327	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590007328	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007329	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590007330	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
435590007331	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
435590007332	putative transporter; Validated; Region: PRK03818
435590007333	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590007334	TrkA-C domain; Region: TrkA_C; pfam02080
435590007335	TrkA-C domain; Region: TrkA_C; pfam02080
435590007336	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590007337	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007338	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007339	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007340	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590007341	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007342	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007343	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007344	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007345	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590007346	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590007347	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007348	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590007349	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590007350	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007351	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590007352	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
435590007353	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590007354	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007355	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590007356	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590007357	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590007358	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590007359	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
435590007360	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
435590007361	active site
435590007362	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
435590007363	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
435590007364	oligomer interface [polypeptide binding]; other site
435590007365	metal binding site [ion binding]; metal-binding site
435590007366	metal binding site [ion binding]; metal-binding site
435590007367	Cl binding site [ion binding]; other site
435590007368	aspartate ring; other site
435590007369	basic sphincter; other site
435590007370	putative hydrophobic gate; other site
435590007371	periplasmic entrance; other site
435590007372	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
435590007373	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
435590007374	putative DNA binding site [nucleotide binding]; other site
435590007375	putative Zn2+ binding site [ion binding]; other site
435590007376	AsnC family; Region: AsnC_trans_reg; pfam01037
435590007377	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
435590007378	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
435590007379	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
435590007380	Phosphate transporter family; Region: PHO4; pfam01384
435590007381	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590007382	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007383	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
435590007384	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
435590007385	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
435590007386	homodimer interface [polypeptide binding]; other site
435590007387	substrate-cofactor binding pocket; other site
435590007388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590007389	catalytic residue [active]
435590007390	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
435590007391	L-lactate permease; Region: Lactate_perm; cl00701
435590007392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007394	ATP binding site [chemical binding]; other site
435590007395	Mg2+ binding site [ion binding]; other site
435590007396	G-X-G motif; other site
435590007397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007398	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590007399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007400	active site
435590007401	phosphorylation site [posttranslational modification]
435590007402	intermolecular recognition site; other site
435590007403	AbgT putative transporter family; Region: ABG_transport; cl17431
435590007404	AbgT putative transporter family; Region: ABG_transport; cl17431
435590007405	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590007406	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
435590007407	AMP-binding domain protein; Validated; Region: PRK08315
435590007408	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590007409	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
435590007410	acyl-activating enzyme (AAE) consensus motif; other site
435590007411	putative AMP binding site [chemical binding]; other site
435590007412	putative active site [active]
435590007413	putative CoA binding site [chemical binding]; other site
435590007414	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
435590007415	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590007416	non-specific DNA binding site [nucleotide binding]; other site
435590007417	salt bridge; other site
435590007418	sequence-specific DNA binding site [nucleotide binding]; other site
435590007419	Cupin domain; Region: Cupin_2; pfam07883
435590007420	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
435590007421	Lumazine binding domain; Region: Lum_binding; pfam00677
435590007422	Lumazine binding domain; Region: Lum_binding; pfam00677
435590007423	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
435590007424	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
435590007425	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590007426	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
435590007427	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590007428	HSP70 interaction site [polypeptide binding]; other site
435590007429	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
435590007430	dimer interface [polypeptide binding]; other site
435590007431	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007433	dimer interface [polypeptide binding]; other site
435590007434	phosphorylation site [posttranslational modification]
435590007435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007436	ATP binding site [chemical binding]; other site
435590007437	Mg2+ binding site [ion binding]; other site
435590007438	G-X-G motif; other site
435590007439	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
435590007440	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
435590007441	active site
435590007442	metal binding site [ion binding]; metal-binding site
435590007443	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
435590007444	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007445	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590007446	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007447	N-terminal plug; other site
435590007448	ligand-binding site [chemical binding]; other site
435590007449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590007450	BNR repeat-like domain; Region: BNR_2; pfam13088
435590007451	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
435590007452	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
435590007453	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590007454	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590007455	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
435590007456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007458	dimer interface [polypeptide binding]; other site
435590007459	phosphorylation site [posttranslational modification]
435590007460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007461	ATP binding site [chemical binding]; other site
435590007462	Mg2+ binding site [ion binding]; other site
435590007463	G-X-G motif; other site
435590007464	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590007465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007466	active site
435590007467	phosphorylation site [posttranslational modification]
435590007468	intermolecular recognition site; other site
435590007469	dimerization interface [polypeptide binding]; other site
435590007470	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590007471	Predicted membrane protein [Function unknown]; Region: COG3059
435590007472	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
435590007473	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590007474	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590007475	protein binding site [polypeptide binding]; other site
435590007476	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590007477	protein binding site [polypeptide binding]; other site
435590007478	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
435590007479	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
435590007480	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007481	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
435590007482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007483	DNA binding residues [nucleotide binding]
435590007484	Clostripain family; Region: Peptidase_C11; pfam03415
435590007485	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
435590007486	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
435590007487	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
435590007488	TrkA-C domain; Region: TrkA_C; pfam02080
435590007489	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590007490	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
435590007491	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
435590007492	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
435590007493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590007494	motif II; other site
435590007495	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
435590007496	oligomerization interface [polypeptide binding]; other site
435590007497	active site
435590007498	metal binding site [ion binding]; metal-binding site
435590007499	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590007500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590007501	putative substrate translocation pore; other site
435590007502	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
435590007503	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590007504	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590007505	ABC transporter; Region: ABC_tran_2; pfam12848
435590007506	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590007507	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
435590007508	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007509	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007510	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007511	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590007512	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007513	N-terminal plug; other site
435590007514	ligand-binding site [chemical binding]; other site
435590007515	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590007516	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590007517	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
435590007518	ribosomal protein S16; Region: S16; TIGR00002
435590007519	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
435590007520	Ferritin-like domain; Region: Ferritin; pfam00210
435590007521	ferroxidase diiron center [ion binding]; other site
435590007522	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
435590007523	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590007524	OPT oligopeptide transporter protein; Region: OPT; pfam03169
435590007525	putative oligopeptide transporter, OPT family; Region: TIGR00733
435590007526	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590007527	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590007528	active site
435590007529	metal binding site [ion binding]; metal-binding site
435590007530	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590007531	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
435590007532	HD domain; Region: HD_4; pfam13328
435590007533	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
435590007534	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
435590007535	synthetase active site [active]
435590007536	NTP binding site [chemical binding]; other site
435590007537	metal binding site [ion binding]; metal-binding site
435590007538	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
435590007539	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
435590007540	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
435590007541	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
435590007542	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
435590007543	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
435590007544	A new structural DNA glycosylase; Region: AlkD_like; cd06561
435590007545	active site
435590007546	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590007547	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590007548	Coenzyme A binding pocket [chemical binding]; other site
435590007549	Predicted transcriptional regulators [Transcription]; Region: COG1695
435590007550	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
435590007551	PspC domain; Region: PspC; pfam04024
435590007552	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
435590007553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007554	ATP-grasp domain; Region: ATP-grasp; pfam02222
435590007555	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
435590007556	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
435590007557	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
435590007558	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
435590007559	Imelysin; Region: Peptidase_M75; pfam09375
435590007560	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
435590007561	Rhomboid family; Region: Rhomboid; cl11446
435590007562	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
435590007563	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
435590007564	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
435590007565	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
435590007566	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590007567	N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795
435590007568	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
435590007569	putative active site [active]
435590007570	catalytic site [active]
435590007571	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
435590007572	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590007573	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590007574	catalytic residue [active]
435590007575	Protein of unknown function (DUF452); Region: DUF452; cl01062
435590007576	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
435590007577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590007578	S-adenosylmethionine binding site [chemical binding]; other site
435590007579	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
435590007580	AAA domain; Region: AAA_26; pfam13500
435590007581	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
435590007582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590007583	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
435590007584	Walker A/P-loop; other site
435590007585	ATP binding site [chemical binding]; other site
435590007586	Q-loop/lid; other site
435590007587	ABC transporter signature motif; other site
435590007588	Walker B; other site
435590007589	D-loop; other site
435590007590	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590007591	Walker A/P-loop; other site
435590007592	ATP binding site [chemical binding]; other site
435590007593	Q-loop/lid; other site
435590007594	ABC transporter signature motif; other site
435590007595	Walker B; other site
435590007596	D-loop; other site
435590007597	H-loop/switch region; other site
435590007598	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
435590007599	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
435590007600	inhibitor site; inhibition site
435590007601	active site
435590007602	dimer interface [polypeptide binding]; other site
435590007603	catalytic residue [active]
435590007604	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
435590007605	Na binding site [ion binding]; other site
435590007606	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
435590007607	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
435590007608	FMN binding site [chemical binding]; other site
435590007609	substrate binding site [chemical binding]; other site
435590007610	putative catalytic residue [active]
435590007611	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
435590007612	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
435590007613	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
435590007614	active site
435590007615	homodimer interface [polypeptide binding]; other site
435590007616	homotetramer interface [polypeptide binding]; other site
435590007617	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590007618	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
435590007619	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
435590007620	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
435590007621	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
435590007622	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
435590007623	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
435590007624	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
435590007625	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
435590007626	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
435590007627	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
435590007628	putative active site [active]
435590007629	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
435590007630	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
435590007631	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
435590007632	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
435590007633	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
435590007634	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
435590007635	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590007636	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590007637	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590007638	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590007639	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590007640	Walker A/P-loop; other site
435590007641	ATP binding site [chemical binding]; other site
435590007642	Q-loop/lid; other site
435590007643	ABC transporter signature motif; other site
435590007644	Walker B; other site
435590007645	D-loop; other site
435590007646	H-loop/switch region; other site
435590007647	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590007648	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590007649	FtsX-like permease family; Region: FtsX; pfam02687
435590007650	Histidine kinase; Region: His_kinase; pfam06580
435590007651	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590007652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007653	active site
435590007654	phosphorylation site [posttranslational modification]
435590007655	intermolecular recognition site; other site
435590007656	dimerization interface [polypeptide binding]; other site
435590007657	LytTr DNA-binding domain; Region: LytTR; smart00850
435590007658	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007659	active site
435590007660	Int/Topo IB signature motif; other site
435590007661	DNA binding site [nucleotide binding]
435590007662	Peptidase M15; Region: Peptidase_M15_3; cl01194
435590007663	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590007664	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007665	active site
435590007666	DNA binding site [nucleotide binding]
435590007667	Int/Topo IB signature motif; other site
435590007668	Protein of unknown function (DUF436); Region: DUF436; cl01860
435590007669	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590007670	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007671	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007672	DNA binding residues [nucleotide binding]
435590007673	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
435590007674	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
435590007675	Phage capsid family; Region: Phage_capsid; pfam05065
435590007676	CpXC protein; Region: CpXC; pfam14353
435590007677	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
435590007678	Phage portal protein; Region: Phage_portal; pfam04860
435590007679	Phage-related protein [Function unknown]; Region: COG4695; cl01923
435590007680	Phage terminase large subunit; Region: Terminase_3; cl12054
435590007681	Terminase small subunit; Region: Terminase_2; pfam03592
435590007682	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590007683	extended (e) SDRs; Region: SDR_e; cd08946
435590007684	NAD(P) binding site [chemical binding]; other site
435590007685	active site
435590007686	substrate binding site [chemical binding]; other site
435590007687	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
435590007688	ParB-like nuclease domain; Region: ParB; smart00470
435590007689	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
435590007690	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590007691	Active Sites [active]
435590007692	Methyltransferase domain; Region: Methyltransf_26; pfam13659
435590007693	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590007694	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007695	active site
435590007696	DNA binding site [nucleotide binding]
435590007697	Int/Topo IB signature motif; other site
435590007698	NUMOD4 motif; Region: NUMOD4; pfam07463
435590007699	DNA-directed RNA polymerase subunit A'; Validated; Region: PRK08566
435590007700	PcfJ-like protein; Region: PcfJ; pfam14284
435590007701	PcfK-like protein; Region: PcfK; pfam14058
435590007702	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590007703	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
435590007704	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
435590007705	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007706	ATP binding site [chemical binding]; other site
435590007707	putative Mg++ binding site [ion binding]; other site
435590007708	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007709	nucleotide binding region [chemical binding]; other site
435590007710	ATP-binding site [chemical binding]; other site
435590007711	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
435590007712	hypothetical protein; Provisional; Region: PRK09741
435590007713	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
435590007714	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
435590007715	dimer interface [polypeptide binding]; other site
435590007716	ssDNA binding site [nucleotide binding]; other site
435590007717	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590007718	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
435590007719	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
435590007720	TspO/MBR family; Region: TspO_MBR; pfam03073
435590007721	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
435590007722	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590007723	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590007724	DNA binding residues [nucleotide binding]
435590007725	dimerization interface [polypeptide binding]; other site
435590007726	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
435590007727	Cysteine-rich domain; Region: CCG; pfam02754
435590007728	Cysteine-rich domain; Region: CCG; pfam02754
435590007729	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
435590007730	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
435590007731	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
435590007732	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
435590007733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590007734	FeS/SAM binding site; other site
435590007735	Pyruvate formate lyase 1; Region: PFL1; cd01678
435590007736	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
435590007737	coenzyme A binding site [chemical binding]; other site
435590007738	active site
435590007739	catalytic residues [active]
435590007740	glycine loop; other site
435590007741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590007742	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590007743	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
435590007744	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
435590007745	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
435590007746	G1 box; other site
435590007747	GTP/Mg2+ binding site [chemical binding]; other site
435590007748	Switch I region; other site
435590007749	G2 box; other site
435590007750	G3 box; other site
435590007751	Switch II region; other site
435590007752	G4 box; other site
435590007753	G5 box; other site
435590007754	Nucleoside recognition; Region: Gate; pfam07670
435590007755	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
435590007756	Nucleoside recognition; Region: Gate; pfam07670
435590007757	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
435590007758	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
435590007759	Ligand Binding Site [chemical binding]; other site
435590007760	TilS substrate C-terminal domain; Region: TilS_C; smart00977
435590007761	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
435590007762	Tetratricopeptide repeat; Region: TPR_15; pfam13429
435590007763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590007764	TPR motif; other site
435590007765	TPR repeat; Region: TPR_11; pfam13414
435590007766	binding surface
435590007767	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
435590007768	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
435590007769	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
435590007770	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
435590007771	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
435590007772	Walker A/P-loop; other site
435590007773	ATP binding site [chemical binding]; other site
435590007774	Q-loop/lid; other site
435590007775	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
435590007776	ABC transporter signature motif; other site
435590007777	Walker B; other site
435590007778	D-loop; other site
435590007779	H-loop/switch region; other site
435590007780	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
435590007781	Flavoprotein; Region: Flavoprotein; pfam02441
435590007782	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
435590007783	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
435590007784	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
435590007785	active site
435590007786	catalytic site [active]
435590007787	substrate binding site [chemical binding]; other site
435590007788	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
435590007789	DNA polymerase III subunit beta; Validated; Region: PRK05643
435590007790	putative DNA binding surface [nucleotide binding]; other site
435590007791	dimer interface [polypeptide binding]; other site
435590007792	beta-clamp/translesion DNA polymerase binding surface; other site
435590007793	beta-clamp/clamp loader binding surface; other site
435590007794	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
435590007795	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
435590007796	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
435590007797	Pantoate-beta-alanine ligase; Region: PanC; cd00560
435590007798	pantoate--beta-alanine ligase; Region: panC; TIGR00018
435590007799	active site
435590007800	ATP-binding site [chemical binding]; other site
435590007801	pantoate-binding site; other site
435590007802	HXXH motif; other site
435590007803	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
435590007804	tetramerization interface [polypeptide binding]; other site
435590007805	active site
435590007806	Transposase domain (DUF772); Region: DUF772; pfam05598
435590007807	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590007808	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
435590007809	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590007810	putative transporter; Validated; Region: PRK03818
435590007811	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590007812	TrkA-C domain; Region: TrkA_C; pfam02080
435590007813	TrkA-C domain; Region: TrkA_C; pfam02080
435590007814	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
435590007815	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
435590007816	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
435590007817	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
435590007818	putative NADH binding site [chemical binding]; other site
435590007819	putative active site [active]
435590007820	nudix motif; other site
435590007821	putative metal binding site [ion binding]; other site
435590007822	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
435590007823	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
435590007824	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
435590007825	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
435590007826	RNA binding site [nucleotide binding]; other site
435590007827	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590007828	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590007829	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590007830	Abi-like protein; Region: Abi_2; pfam07751
435590007831	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590007832	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007833	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590007834	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590007835	Two component regulator propeller; Region: Reg_prop; pfam07494
435590007836	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590007837	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590007838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007839	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007840	dimer interface [polypeptide binding]; other site
435590007841	phosphorylation site [posttranslational modification]
435590007842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007843	ATP binding site [chemical binding]; other site
435590007844	Mg2+ binding site [ion binding]; other site
435590007845	G-X-G motif; other site
435590007846	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590007847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007848	active site
435590007849	phosphorylation site [posttranslational modification]
435590007850	intermolecular recognition site; other site
435590007851	dimerization interface [polypeptide binding]; other site
435590007852	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590007853	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590007854	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
435590007855	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007856	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007857	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007858	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590007859	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590007860	SusD family; Region: SusD; pfam07980
435590007861	Pectate lyase; Region: Pec_lyase_C; cl01593
435590007862	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
435590007863	Pectate lyase; Region: Pec_lyase_C; cl01593
435590007864	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590007865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007866	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007867	DNA binding residues [nucleotide binding]
435590007868	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007869	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007870	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007871	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007872	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590007873	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007874	SusD family; Region: SusD; pfam07980
435590007875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590007876	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590007877	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590007878	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007879	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590007880	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590007881	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590007882	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590007883	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590007884	SusD family; Region: SusD; pfam07980
435590007885	Transposase domain (DUF772); Region: DUF772; pfam05598
435590007886	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590007887	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
435590007888	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
435590007889	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
435590007890	putative transporter; Provisional; Region: PRK10484
435590007891	Na binding site [ion binding]; other site
435590007892	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
435590007893	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
435590007894	B12 binding site [chemical binding]; other site
435590007895	cobalt ligand [ion binding]; other site
435590007896	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
435590007897	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590007898	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
435590007899	active site
435590007900	homotrimer interface [polypeptide binding]; other site
435590007901	catalytic site [active]
435590007902	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
435590007903	Right handed beta helix region; Region: Beta_helix; pfam13229
435590007904	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
435590007905	transcription termination factor Rho; Provisional; Region: rho; PRK09376
435590007906	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
435590007907	RNA binding site [nucleotide binding]; other site
435590007908	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
435590007909	multimer interface [polypeptide binding]; other site
435590007910	Walker A motif; other site
435590007911	ATP binding site [chemical binding]; other site
435590007912	Walker B motif; other site
435590007913	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
435590007914	homotrimer interaction site [polypeptide binding]; other site
435590007915	putative active site [active]
435590007916	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
435590007917	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
435590007918	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590007919	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
435590007920	dimer interface [polypeptide binding]; other site
435590007921	active site
435590007922	metal binding site [ion binding]; metal-binding site
435590007923	glutathione binding site [chemical binding]; other site
435590007924	Domain of unknown function (DUF3805); Region: DUF3805; pfam12712
435590007925	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
435590007926	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590007927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590007928	Walker A/P-loop; other site
435590007929	ATP binding site [chemical binding]; other site
435590007930	Q-loop/lid; other site
435590007931	ABC transporter signature motif; other site
435590007932	Walker B; other site
435590007933	D-loop; other site
435590007934	H-loop/switch region; other site
435590007935	ABC transporter; Region: ABC_tran_2; pfam12848
435590007936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
435590007937	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590007938	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007939	active site
435590007940	DNA binding site [nucleotide binding]
435590007941	Int/Topo IB signature motif; other site
435590007942	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
435590007943	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
435590007944	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590007945	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590007946	4Fe-4S binding domain; Region: Fer4; pfam00037
435590007947	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590007948	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590007949	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590007950	active site
435590007951	homodimer interface [polypeptide binding]; other site
435590007952	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932
435590007953	NodB motif; other site
435590007954	putative active site [active]
435590007955	putative catalytic site [active]
435590007956	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590007957	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590007958	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590007959	active site
435590007960	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
435590007961	substrate binding site; other site
435590007962	dimer interface; other site
435590007963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007964	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590007965	NAD(P) binding site [chemical binding]; other site
435590007966	active site
435590007967	LicD family; Region: LicD; pfam04991
435590007968	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
435590007969	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590007970	Probable Catalytic site; other site
435590007971	metal-binding site
435590007972	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590007973	extended (e) SDRs; Region: SDR_e; cd08946
435590007974	NAD(P) binding site [chemical binding]; other site
435590007975	active site
435590007976	substrate binding site [chemical binding]; other site
435590007977	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590007978	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590007979	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590007980	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590007981	amidase catalytic site [active]
435590007982	Zn binding residues [ion binding]; other site
435590007983	substrate binding site [chemical binding]; other site
435590007984	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590007985	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590007986	VirE N-terminal domain; Region: VirE_N; pfam08800
435590007987	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590007988	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590007989	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
435590007990	metal binding triad [ion binding]; metal-binding site
435590007991	HEPN domain; Region: HEPN; cl00824
435590007992	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
435590007993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007994	ATP binding site [chemical binding]; other site
435590007995	putative Mg++ binding site [ion binding]; other site
435590007996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007997	nucleotide binding region [chemical binding]; other site
435590007998	ATP-binding site [chemical binding]; other site
435590007999	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
435590008000	G1 box; other site
435590008001	GTP/Mg2+ binding site [chemical binding]; other site
435590008002	Switch I region; other site
435590008003	G2 box; other site
435590008004	G3 box; other site
435590008005	Switch II region; other site
435590008006	G4 box; other site
435590008007	G5 box; other site
435590008008	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
435590008009	Na binding site [ion binding]; other site
435590008010	recombination protein RecR; Reviewed; Region: recR; PRK00076
435590008011	RecR protein; Region: RecR; pfam02132
435590008012	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
435590008013	putative active site [active]
435590008014	putative metal-binding site [ion binding]; other site
435590008015	tetramer interface [polypeptide binding]; other site
435590008016	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590008017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590008018	Coenzyme A binding pocket [chemical binding]; other site
435590008019	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
435590008020	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590008021	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
435590008022	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
435590008023	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
435590008024	Hemerythrin-like domain; Region: Hr-like; cd12108
435590008025	Fe binding site [ion binding]; other site
435590008026	hybrid cluster protein; Provisional; Region: PRK05290
435590008027	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590008028	ACS interaction site; other site
435590008029	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
435590008030	hybrid metal cluster; other site
435590008031	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590008032	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590008033	ligand binding site [chemical binding]; other site
435590008034	flexible hinge region; other site
435590008035	non-specific DNA interactions [nucleotide binding]; other site
435590008036	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
435590008037	DNA binding site [nucleotide binding]
435590008038	sequence specific DNA binding site [nucleotide binding]; other site
435590008039	putative cAMP binding site [chemical binding]; other site
435590008040	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590008041	Sulfatase; Region: Sulfatase; pfam00884
435590008042	NigD-like protein; Region: NigD; pfam12667
435590008043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590008044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008045	active site
435590008046	phosphorylation site [posttranslational modification]
435590008047	intermolecular recognition site; other site
435590008048	dimerization interface [polypeptide binding]; other site
435590008049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590008050	DNA binding site [nucleotide binding]
435590008051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590008052	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590008053	dimer interface [polypeptide binding]; other site
435590008054	phosphorylation site [posttranslational modification]
435590008055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008056	ATP binding site [chemical binding]; other site
435590008057	Mg2+ binding site [ion binding]; other site
435590008058	G-X-G motif; other site
435590008059	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008060	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008061	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590008062	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
435590008063	putative active site [active]
435590008064	putative metal binding site [ion binding]; other site
435590008065	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
435590008066	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590008067	polyphosphate kinase; Provisional; Region: PRK05443
435590008068	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
435590008069	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
435590008070	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
435590008071	domain interface [polypeptide binding]; other site
435590008072	active site
435590008073	catalytic site [active]
435590008074	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
435590008075	domain interface [polypeptide binding]; other site
435590008076	active site
435590008077	catalytic site [active]
435590008078	exopolyphosphatase; Region: exo_poly_only; TIGR03706
435590008079	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
435590008080	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590008081	M28 Zn-Peptidases; Region: M28_like_4; cd08015
435590008082	Peptidase family M28; Region: Peptidase_M28; pfam04389
435590008083	metal binding site [ion binding]; metal-binding site
435590008084	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
435590008085	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
435590008086	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
435590008087	alpha subunit interaction interface [polypeptide binding]; other site
435590008088	Walker A motif; other site
435590008089	ATP binding site [chemical binding]; other site
435590008090	Walker B motif; other site
435590008091	inhibitor binding site; inhibition site
435590008092	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
435590008093	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
435590008094	gamma subunit interface [polypeptide binding]; other site
435590008095	LBP interface [polypeptide binding]; other site
435590008096	ATP synthase A chain; Region: ATP-synt_A; cl00413
435590008097	ATP synthase subunit C; Region: ATP-synt_C; cl00466
435590008098	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
435590008099	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
435590008100	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
435590008101	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
435590008102	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
435590008103	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
435590008104	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
435590008105	beta subunit interaction interface [polypeptide binding]; other site
435590008106	Walker A motif; other site
435590008107	ATP binding site [chemical binding]; other site
435590008108	Walker B motif; other site
435590008109	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
435590008110	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
435590008111	core domain interface [polypeptide binding]; other site
435590008112	delta subunit interface [polypeptide binding]; other site
435590008113	epsilon subunit interface [polypeptide binding]; other site
435590008114	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590008115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008116	S-adenosylmethionine binding site [chemical binding]; other site
435590008117	MoxR-like ATPases [General function prediction only]; Region: COG0714
435590008118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008119	Walker A motif; other site
435590008120	ATP binding site [chemical binding]; other site
435590008121	Walker B motif; other site
435590008122	arginine finger; other site
435590008123	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
435590008124	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008125	metal ion-dependent adhesion site (MIDAS); other site
435590008126	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590008127	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
435590008128	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590008129	catalytic residue [active]
435590008130	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
435590008131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008132	motif II; other site
435590008133	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
435590008134	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
435590008135	Part of AAA domain; Region: AAA_19; pfam13245
435590008136	Family description; Region: UvrD_C_2; pfam13538
435590008137	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
435590008138	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
435590008139	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
435590008140	dimer interface [polypeptide binding]; other site
435590008141	active site
435590008142	metal binding site [ion binding]; metal-binding site
435590008143	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
435590008144	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
435590008145	Potassium binding sites [ion binding]; other site
435590008146	Cesium cation binding sites [ion binding]; other site
435590008147	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
435590008148	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590008149	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590008150	glycine dehydrogenase; Provisional; Region: PRK05367
435590008151	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
435590008152	tetramer interface [polypeptide binding]; other site
435590008153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008154	catalytic residue [active]
435590008155	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
435590008156	tetramer interface [polypeptide binding]; other site
435590008157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008158	catalytic residue [active]
435590008159	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
435590008160	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
435590008161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008162	S-adenosylmethionine binding site [chemical binding]; other site
435590008163	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
435590008164	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
435590008165	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
435590008166	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
435590008167	metal-binding site [ion binding]
435590008168	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590008169	Soluble P-type ATPase [General function prediction only]; Region: COG4087
435590008170	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
435590008171	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590008172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590008173	Coenzyme A binding pocket [chemical binding]; other site
435590008174	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
435590008175	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590008176	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
435590008177	acyl-activating enzyme (AAE) consensus motif; other site
435590008178	putative AMP binding site [chemical binding]; other site
435590008179	putative active site [active]
435590008180	putative CoA binding site [chemical binding]; other site
435590008181	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008182	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
435590008183	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
435590008184	putative DNA-binding cleft [nucleotide binding]; other site
435590008185	dimer interface [polypeptide binding]; other site
435590008186	active site
435590008187	pullulanase, type I; Region: pulA_typeI; TIGR02104
435590008188	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
435590008189	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
435590008190	Ca binding site [ion binding]; other site
435590008191	active site
435590008192	catalytic site [active]
435590008193	mannonate dehydratase; Provisional; Region: PRK03906
435590008194	mannonate dehydratase; Region: uxuA; TIGR00695
435590008195	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
435590008196	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590008197	active site
435590008198	nucleophile elbow; other site
435590008199	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590008200	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
435590008201	active site
435590008202	catalytic site [active]
435590008203	substrate binding site [chemical binding]; other site
435590008204	Uncharacterized conserved protein [Function unknown]; Region: COG1739
435590008205	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
435590008206	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
435590008207	excinuclease ABC subunit B; Provisional; Region: PRK05298
435590008208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590008209	ATP binding site [chemical binding]; other site
435590008210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590008211	nucleotide binding region [chemical binding]; other site
435590008212	ATP-binding site [chemical binding]; other site
435590008213	Ultra-violet resistance protein B; Region: UvrB; pfam12344
435590008214	UvrB/uvrC motif; Region: UVR; pfam02151
435590008215	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590008216	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
435590008217	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
435590008218	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590008219	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590008220	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
435590008221	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590008222	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
435590008223	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590008224	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
435590008225	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
435590008226	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
435590008227	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
435590008228	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
435590008229	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
435590008230	putative deacylase active site [active]
435590008231	POT family; Region: PTR2; cl17359
435590008232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590008233	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
435590008234	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590008235	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
435590008236	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
435590008237	galactarate dehydratase; Region: galactar-dH20; TIGR03248
435590008238	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
435590008239	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
435590008240	DNA binding site [nucleotide binding]
435590008241	domain linker motif; other site
435590008242	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
435590008243	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
435590008244	ligand binding site [chemical binding]; other site
435590008245	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590008246	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590008247	substrate binding site [chemical binding]; other site
435590008248	ATP binding site [chemical binding]; other site
435590008249	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
435590008250	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
435590008251	active site
435590008252	intersubunit interface [polypeptide binding]; other site
435590008253	catalytic residue [active]
435590008254	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
435590008255	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590008256	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590008257	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
435590008258	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
435590008259	HIGH motif; other site
435590008260	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590008261	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590008262	active site
435590008263	KMSKS motif; other site
435590008264	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
435590008265	tRNA binding surface [nucleotide binding]; other site
435590008266	anticodon binding site; other site
435590008267	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
435590008268	lipoprotein signal peptidase; Provisional; Region: PRK14788
435590008269	lipoprotein signal peptidase; Provisional; Region: PRK14787
435590008270	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
435590008271	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
435590008272	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
435590008273	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
435590008274	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590008275	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
435590008276	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
435590008277	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590008278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590008279	DNA binding site [nucleotide binding]
435590008280	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590008281	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590008282	catalytic residues [active]
435590008283	glucuronate isomerase; Reviewed; Region: PRK02925
435590008284	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
435590008285	altronate oxidoreductase; Provisional; Region: PRK03643
435590008286	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
435590008287	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
435590008288	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
435590008289	active site
435590008290	SAM binding site [chemical binding]; other site
435590008291	homodimer interface [polypeptide binding]; other site
435590008292	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
435590008293	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590008294	intersubunit interface [polypeptide binding]; other site
435590008295	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
435590008296	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590008297	ABC-ATPase subunit  interface; other site
435590008298	dimer interface [polypeptide binding]; other site
435590008299	putative PBP binding regions; other site
435590008300	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
435590008301	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
435590008302	Walker A/P-loop; other site
435590008303	ATP binding site [chemical binding]; other site
435590008304	Q-loop/lid; other site
435590008305	ABC transporter signature motif; other site
435590008306	Walker B; other site
435590008307	D-loop; other site
435590008308	H-loop/switch region; other site
435590008309	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
435590008310	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
435590008311	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
435590008312	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
435590008313	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
435590008314	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
435590008315	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
435590008316	active site
435590008317	SAM binding site [chemical binding]; other site
435590008318	homodimer interface [polypeptide binding]; other site
435590008319	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
435590008320	active site
435590008321	putative homodimer interface [polypeptide binding]; other site
435590008322	SAM binding site [chemical binding]; other site
435590008323	cobalt-precorrin-6Y C(15)-methyltransferase; Provisional; Region: cbiT; PRK00377
435590008324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008325	S-adenosylmethionine binding site [chemical binding]; other site
435590008326	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
435590008327	active site
435590008328	SAM binding site [chemical binding]; other site
435590008329	homodimer interface [polypeptide binding]; other site
435590008330	Precorrin-8X methylmutase; Region: CbiC; pfam02570
435590008331	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
435590008332	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
435590008333	flavodoxin; Provisional; Region: PRK07116
435590008334	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590008335	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590008336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590008337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590008338	Coenzyme A binding pocket [chemical binding]; other site
435590008339	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
435590008340	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590008341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590008342	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590008343	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590008344	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
435590008345	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
435590008346	TPP-binding site; other site
435590008347	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590008348	PYR/PP interface [polypeptide binding]; other site
435590008349	dimer interface [polypeptide binding]; other site
435590008350	TPP binding site [chemical binding]; other site
435590008351	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590008352	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
435590008353	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590008354	putative ligand binding site [chemical binding]; other site
435590008355	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590008356	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590008357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008358	N-terminal plug; other site
435590008359	ligand-binding site [chemical binding]; other site
435590008360	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590008361	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590008362	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008363	N-terminal plug; other site
435590008364	ligand-binding site [chemical binding]; other site
435590008365	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
435590008366	FAD binding site [chemical binding]; other site
435590008367	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
435590008368	dimer interface [polypeptide binding]; other site
435590008369	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
435590008370	putative radical transfer pathway; other site
435590008371	diiron center [ion binding]; other site
435590008372	tyrosyl radical; other site
435590008373	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364
435590008374	ATP cone domain; Region: ATP-cone; pfam03477
435590008375	Class I ribonucleotide reductase; Region: RNR_I; cd01679
435590008376	active site
435590008377	dimer interface [polypeptide binding]; other site
435590008378	catalytic residues [active]
435590008379	effector binding site; other site
435590008380	R2 peptide binding site; other site
435590008381	RNA polymerase sigma factor; Provisional; Region: PRK12546
435590008382	Putative cyclase; Region: Cyclase; cl00814
435590008383	putative transporter; Validated; Region: PRK03818
435590008384	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590008385	TrkA-C domain; Region: TrkA_C; pfam02080
435590008386	TrkA-C domain; Region: TrkA_C; pfam02080
435590008387	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590008388	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590008389	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
435590008390	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
435590008391	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590008392	carboxyltransferase (CT) interaction site; other site
435590008393	biotinylation site [posttranslational modification]; other site
435590008394	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
435590008395	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590008396	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
435590008397	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
435590008398	ATP cone domain; Region: ATP-cone; pfam03477
435590008399	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
435590008400	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
435590008401	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
435590008402	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
435590008403	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
435590008404	active site
435590008405	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
435590008406	active site
435590008407	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590008408	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008409	N-terminal plug; other site
435590008410	ligand-binding site [chemical binding]; other site
435590008411	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590008412	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590008413	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008414	N-terminal plug; other site
435590008415	ligand-binding site [chemical binding]; other site
435590008416	putative transporter; Validated; Region: PRK03818
435590008417	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
435590008418	TrkA-C domain; Region: TrkA_C; pfam02080
435590008419	TrkA-C domain; Region: TrkA_C; pfam02080
435590008420	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
435590008421	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
435590008422	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
435590008423	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
435590008424	catalytic triad [active]
435590008425	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
435590008426	cobyric acid synthase; Provisional; Region: PRK00784
435590008427	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
435590008428	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
435590008429	catalytic triad [active]
435590008430	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
435590008431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590008432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008433	homodimer interface [polypeptide binding]; other site
435590008434	catalytic residue [active]
435590008435	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
435590008436	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590008437	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008438	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590008439	active site
435590008440	DNA binding site [nucleotide binding]
435590008441	Int/Topo IB signature motif; other site
435590008442	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
435590008443	DEAD-like helicases superfamily; Region: DEXDc; smart00487
435590008444	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590008445	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
435590008446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590008447	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590008448	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590008449	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008450	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590008451	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008452	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
435590008453	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590008454	catalytic core [active]
435590008455	cobalamin synthase; Reviewed; Region: cobS; PRK00235
435590008456	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
435590008457	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
435590008458	active site pocket [active]
435590008459	putative dimer interface [polypeptide binding]; other site
435590008460	putative cataytic base [active]
435590008461	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
435590008462	homotrimer interface [polypeptide binding]; other site
435590008463	Walker A motif; other site
435590008464	GTP binding site [chemical binding]; other site
435590008465	Walker B motif; other site
435590008466	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
435590008467	phosphopeptide binding site; other site
435590008468	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
435590008469	Sporulation related domain; Region: SPOR; pfam05036
435590008470	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
435590008471	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590008472	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
435590008473	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
435590008474	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590008475	ATP binding site [chemical binding]; other site
435590008476	Mg++ binding site [ion binding]; other site
435590008477	motif III; other site
435590008478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590008479	nucleotide binding region [chemical binding]; other site
435590008480	ATP-binding site [chemical binding]; other site
435590008481	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
435590008482	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
435590008483	phosphoserine phosphatase SerB; Region: serB; TIGR00338
435590008484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008485	motif II; other site
435590008486	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590008487	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590008488	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
435590008489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008490	motif II; other site
435590008491	Predicted permeases [General function prediction only]; Region: COG0795
435590008492	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
435590008493	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
435590008494	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
435590008495	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
435590008496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008497	Walker A motif; other site
435590008498	ATP binding site [chemical binding]; other site
435590008499	Walker B motif; other site
435590008500	arginine finger; other site
435590008501	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
435590008502	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
435590008503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008504	S-adenosylmethionine binding site [chemical binding]; other site
435590008505	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
435590008506	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
435590008507	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590008508	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590008509	substrate-cofactor binding pocket; other site
435590008510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008511	catalytic residue [active]
435590008512	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
435590008513	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008514	FtsX-like permease family; Region: FtsX; pfam02687
435590008515	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008516	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590008517	Walker A/P-loop; other site
435590008518	ATP binding site [chemical binding]; other site
435590008519	Q-loop/lid; other site
435590008520	ABC transporter signature motif; other site
435590008521	Walker B; other site
435590008522	D-loop; other site
435590008523	H-loop/switch region; other site
435590008524	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008525	FtsX-like permease family; Region: FtsX; pfam02687
435590008526	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590008527	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008528	FtsX-like permease family; Region: FtsX; pfam02687
435590008529	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008530	FtsX-like permease family; Region: FtsX; pfam02687
435590008531	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008532	FtsX-like permease family; Region: FtsX; pfam02687
435590008533	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590008534	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590008535	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
435590008536	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
435590008537	Sel1-like repeats; Region: SEL1; smart00671
435590008538	Sel1-like repeats; Region: SEL1; smart00671
435590008539	Sel1-like repeats; Region: SEL1; smart00671
435590008540	Sel1-like repeats; Region: SEL1; smart00671
435590008541	Sel1-like repeats; Region: SEL1; smart00671
435590008542	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008544	active site
435590008545	phosphorylation site [posttranslational modification]
435590008546	intermolecular recognition site; other site
435590008547	dimerization interface [polypeptide binding]; other site
435590008548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008549	Walker A motif; other site
435590008550	ATP binding site [chemical binding]; other site
435590008551	Walker B motif; other site
435590008552	arginine finger; other site
435590008553	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590008554	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
435590008555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008556	ATP binding site [chemical binding]; other site
435590008557	Mg2+ binding site [ion binding]; other site
435590008558	G-X-G motif; other site
435590008559	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590008560	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008561	active site
435590008562	DNA binding site [nucleotide binding]
435590008563	Int/Topo IB signature motif; other site
435590008564	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590008565	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590008566	MPN+ (JAMM) motif; other site
435590008567	Zinc-binding site [ion binding]; other site
435590008568	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
435590008569	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
435590008570	catalytic residues [active]
435590008571	catalytic nucleophile [active]
435590008572	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
435590008573	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
435590008574	DNA binding residues [nucleotide binding]
435590008575	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590008576	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
435590008577	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008578	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008579	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008580	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008581	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008582	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590008583	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590008584	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
435590008585	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008587	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590008588	Walker A motif; other site
435590008589	ATP binding site [chemical binding]; other site
435590008590	Walker B motif; other site
435590008591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590008592	Integrase core domain; Region: rve; pfam00665
435590008593	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590008594	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590008595	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590008596	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590008597	SusD family; Region: SusD; pfam07980
435590008598	Ion channel; Region: Ion_trans_2; pfam07885
435590008599	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590008600	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590008601	NVEALA protein; Region: NVEALA; pfam14055
435590008602	KilA-N domain; Region: KilA-N; pfam04383
435590008603	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
435590008604	peptide synthase; Provisional; Region: PRK12316
435590008605	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
435590008606	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
435590008607	GDP-Fucose binding site [chemical binding]; other site
435590008608	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590008609	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590008610	Ion transport protein; Region: Ion_trans; pfam00520
435590008611	Ion channel; Region: Ion_trans_2; pfam07885
435590008612	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590008613	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590008614	flavodoxin FldA; Validated; Region: PRK09267
435590008615	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
435590008616	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590008617	catalytic residues [active]
435590008618	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
435590008619	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
435590008620	dimer interface [polypeptide binding]; other site
435590008621	anticodon binding site; other site
435590008622	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
435590008623	homodimer interface [polypeptide binding]; other site
435590008624	motif 1; other site
435590008625	active site
435590008626	motif 2; other site
435590008627	GAD domain; Region: GAD; pfam02938
435590008628	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
435590008629	motif 3; other site
435590008630	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
435590008631	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
435590008632	DNA binding site [nucleotide binding]
435590008633	active site
435590008634	Surfeit locus protein 6; Region: SURF6; pfam04935
435590008635	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590008636	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
435590008637	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
435590008638	putative active site; other site
435590008639	catalytic triad [active]
435590008640	putative dimer interface [polypeptide binding]; other site
435590008641	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
435590008642	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
435590008643	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590008644	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
435590008645	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
435590008646	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
435590008647	trimer interface [polypeptide binding]; other site
435590008648	active site
435590008649	G bulge; other site
435590008650	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590008651	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590008652	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590008653	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590008654	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590008655	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
435590008656	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
435590008657	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
435590008658	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
435590008659	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
435590008660	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
435590008661	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
435590008662	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
435590008663	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
435590008664	catalytic loop [active]
435590008665	iron binding site [ion binding]; other site
435590008666	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
435590008667	FAD binding pocket [chemical binding]; other site
435590008668	FAD binding motif [chemical binding]; other site
435590008669	phosphate binding motif [ion binding]; other site
435590008670	beta-alpha-beta structure motif; other site
435590008671	NAD binding pocket [chemical binding]; other site
435590008672	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
435590008673	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
435590008674	ATP binding site [chemical binding]; other site
435590008675	putative Mg++ binding site [ion binding]; other site
435590008676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590008677	nucleotide binding region [chemical binding]; other site
435590008678	ATP-binding site [chemical binding]; other site
435590008679	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
435590008680	RNA binding site [nucleotide binding]; other site
435590008681	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
435590008682	homodimer interface [polypeptide binding]; other site
435590008683	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
435590008684	substrate-cofactor binding pocket; other site
435590008685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008686	catalytic residue [active]
435590008687	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
435590008688	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
435590008689	putative ligand binding site [chemical binding]; other site
435590008690	putative NAD binding site [chemical binding]; other site
435590008691	putative catalytic site [active]
435590008692	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
435590008693	Uncharacterized conserved protein [Function unknown]; Region: COG4198
435590008694	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
435590008695	EamA-like transporter family; Region: EamA; pfam00892
435590008696	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590008697	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590008698	active site
435590008699	Fn3 associated; Region: Fn3_assoc; pfam13287
435590008700	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590008701	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
435590008702	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
435590008703	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
435590008704	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008705	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
435590008706	active site
435590008707	motif I; other site
435590008708	motif II; other site
435590008709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008710	RmuC family; Region: RmuC; pfam02646
435590008711	MgtC family; Region: MgtC; pfam02308
435590008712	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
435590008713	dimerization interface [polypeptide binding]; other site
435590008714	PAS domain; Region: PAS; smart00091
435590008715	putative active site [active]
435590008716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590008717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590008718	dimer interface [polypeptide binding]; other site
435590008719	phosphorylation site [posttranslational modification]
435590008720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008721	ATP binding site [chemical binding]; other site
435590008722	Mg2+ binding site [ion binding]; other site
435590008723	G-X-G motif; other site
435590008724	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
435590008725	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
435590008726	Ligand Binding Site [chemical binding]; other site
435590008727	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590008728	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
435590008729	dimer interface [polypeptide binding]; other site
435590008730	ADP-ribose binding site [chemical binding]; other site
435590008731	active site
435590008732	nudix motif; other site
435590008733	metal binding site [ion binding]; metal-binding site
435590008734	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590008735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008736	S-adenosylmethionine binding site [chemical binding]; other site
435590008737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590008738	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
435590008739	Coenzyme A binding pocket [chemical binding]; other site
435590008740	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
435590008741	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
435590008742	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
435590008743	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
435590008744	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
435590008745	active site
435590008746	homotetramer interface [polypeptide binding]; other site
435590008747	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
435590008748	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
435590008749	substrate binding site [chemical binding]; other site
435590008750	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590008751	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590008752	Chloramphenicol acetyltransferase; Region: CAT; smart01059
435590008753	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
435590008754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008755	motif II; other site
435590008756	potassium-transporting ATPase subunit C; Provisional; Region: PRK14002
435590008757	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
435590008758	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590008759	Soluble P-type ATPase [General function prediction only]; Region: COG4087
435590008760	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
435590008761	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
435590008762	putative ADP-ribose binding site [chemical binding]; other site
435590008763	putative active site [active]
435590008764	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008766	active site
435590008767	phosphorylation site [posttranslational modification]
435590008768	intermolecular recognition site; other site
435590008769	dimerization interface [polypeptide binding]; other site
435590008770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008771	Walker B motif; other site
435590008772	arginine finger; other site
435590008773	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590008774	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
435590008775	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
435590008776	Walker A/P-loop; other site
435590008777	ATP binding site [chemical binding]; other site
435590008778	Q-loop/lid; other site
435590008779	ABC transporter signature motif; other site
435590008780	Walker B; other site
435590008781	D-loop; other site
435590008782	H-loop/switch region; other site
435590008783	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
435590008784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590008785	dimer interface [polypeptide binding]; other site
435590008786	conserved gate region; other site
435590008787	putative PBP binding loops; other site
435590008788	ABC-ATPase subunit interface; other site
435590008789	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
435590008790	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
435590008791	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
435590008792	EamA-like transporter family; Region: EamA; pfam00892
435590008793	EamA-like transporter family; Region: EamA; pfam00892
435590008794	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590008795	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590008796	active site
435590008797	substrate binding site [chemical binding]; other site
435590008798	trimer interface [polypeptide binding]; other site
435590008799	CoA binding site [chemical binding]; other site
435590008800	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
435590008801	methionine aminopeptidase; Provisional; Region: PRK12318
435590008802	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
435590008803	active site
435590008804	UGMP family protein; Validated; Region: PRK09604
435590008805	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
435590008806	Competence-damaged protein; Region: CinA; pfam02464
435590008807	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
435590008808	ribosomal protein L33; Region: rpl33; CHL00104
435590008809	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
435590008810	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
435590008811	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590008812	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
435590008813	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590008814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590008815	FeS/SAM binding site; other site
435590008816	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590008817	IHF dimer interface [polypeptide binding]; other site
435590008818	IHF - DNA interface [nucleotide binding]; other site
435590008819	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590008820	IHF dimer interface [polypeptide binding]; other site
435590008821	IHF - DNA interface [nucleotide binding]; other site
435590008822	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
435590008823	MoxR-like ATPases [General function prediction only]; Region: COG0714
435590008824	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008825	Walker A motif; other site
435590008826	ATP binding site [chemical binding]; other site
435590008827	Walker B motif; other site
435590008828	arginine finger; other site
435590008829	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
435590008830	Protein of unknown function DUF58; Region: DUF58; pfam01882
435590008831	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008832	metal ion-dependent adhesion site (MIDAS); other site
435590008833	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
435590008834	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
435590008835	metal ion-dependent adhesion site (MIDAS); other site
435590008836	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008837	metal ion-dependent adhesion site (MIDAS); other site
435590008838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590008839	binding surface
435590008840	TPR motif; other site
435590008841	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590008842	Oxygen tolerance; Region: BatD; pfam13584
435590008843	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590008844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590008845	TPR motif; other site
435590008846	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
435590008847	active site
435590008848	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
435590008849	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
435590008850	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
435590008851	Ligand Binding Site [chemical binding]; other site
435590008852	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
435590008853	Ligand Binding Site [chemical binding]; other site
435590008854	Transposase domain (DUF772); Region: DUF772; pfam05598
435590008855	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590008856	DNA gyrase subunit A; Validated; Region: PRK05560
435590008857	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
435590008858	CAP-like domain; other site
435590008859	active site
435590008860	primary dimer interface [polypeptide binding]; other site
435590008861	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008862	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008863	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008864	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008865	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008866	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008867	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
435590008868	Clp amino terminal domain; Region: Clp_N; pfam02861
435590008869	Clp amino terminal domain; Region: Clp_N; pfam02861
435590008870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008871	Walker A motif; other site
435590008872	ATP binding site [chemical binding]; other site
435590008873	Walker B motif; other site
435590008874	arginine finger; other site
435590008875	UvrB/uvrC motif; Region: UVR; pfam02151
435590008876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008877	Walker A motif; other site
435590008878	ATP binding site [chemical binding]; other site
435590008879	Walker B motif; other site
435590008880	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
435590008881	heat shock protein 90; Provisional; Region: PRK05218
435590008882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008883	ATP binding site [chemical binding]; other site
435590008884	Mg2+ binding site [ion binding]; other site
435590008885	G-X-G motif; other site
435590008886	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
435590008887	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590008888	active site
435590008889	nucleophile elbow; other site
435590008890	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
435590008891	dihydrodipicolinate synthase; Region: dapA; TIGR00674
435590008892	dimer interface [polypeptide binding]; other site
435590008893	active site
435590008894	catalytic residue [active]
435590008895	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
435590008896	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
435590008897	nucleotide binding pocket [chemical binding]; other site
435590008898	K-X-D-G motif; other site
435590008899	catalytic site [active]
435590008900	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
435590008901	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
435590008902	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
435590008903	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
435590008904	Dimer interface [polypeptide binding]; other site
435590008905	BRCT sequence motif; other site
435590008906	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
435590008907	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
435590008908	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
435590008909	heterodimer interface [polypeptide binding]; other site
435590008910	active site
435590008911	FMN binding site [chemical binding]; other site
435590008912	homodimer interface [polypeptide binding]; other site
435590008913	substrate binding site [chemical binding]; other site
435590008914	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
435590008915	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
435590008916	FAD binding pocket [chemical binding]; other site
435590008917	FAD binding motif [chemical binding]; other site
435590008918	phosphate binding motif [ion binding]; other site
435590008919	beta-alpha-beta structure motif; other site
435590008920	NAD binding pocket [chemical binding]; other site
435590008921	Iron coordination center [ion binding]; other site
435590008922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590008923	sequence-specific DNA binding site [nucleotide binding]; other site
435590008924	salt bridge; other site
435590008925	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
435590008926	DNA polymerase III, delta subunit; Region: holA; TIGR01128
435590008927	AMP nucleosidase; Provisional; Region: PRK07115
435590008928	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
435590008929	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
435590008930	Putative zinc ribbon domain; Region: DUF164; pfam02591
435590008931	Uncharacterized conserved protein [Function unknown]; Region: COG0327
435590008932	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
435590008933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
435590008934	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
435590008935	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
435590008936	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590008938	Walker A/P-loop; other site
435590008939	ATP binding site [chemical binding]; other site
435590008940	Q-loop/lid; other site
435590008941	ABC transporter signature motif; other site
435590008942	Walker B; other site
435590008943	D-loop; other site
435590008944	H-loop/switch region; other site
435590008945	prolyl-tRNA synthetase; Provisional; Region: PRK08661
435590008946	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
435590008947	dimer interface [polypeptide binding]; other site
435590008948	motif 1; other site
435590008949	active site
435590008950	motif 2; other site
435590008951	motif 3; other site
435590008952	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
435590008953	anticodon binding site; other site
435590008954	zinc-binding site [ion binding]; other site
435590008955	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
435590008956	N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854
435590008957	Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321
435590008958	active site
435590008959	catalytic site [active]
435590008960	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
435590008961	Domain of unknown function (DUF386); Region: DUF386; cl01047
435590008962	TIGR02453 family protein; Region: TIGR02453
435590008963	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
435590008964	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
435590008965	active site
435590008966	dimerization interface [polypeptide binding]; other site
435590008967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
435590008968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
435590008969	MORN repeat; Region: MORN; cl14787
435590008970	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590008971	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590008972	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
435590008973	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
435590008974	Ligand binding site; other site
435590008975	oligomer interface; other site
435590008976	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
435590008977	catalytic center binding site [active]
435590008978	ATP binding site [chemical binding]; other site
435590008979	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
435590008980	ABC-2 type transporter; Region: ABC2_membrane; cl17235
435590008981	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
435590008982	active site
435590008983	intersubunit interactions; other site
435590008984	catalytic residue [active]
435590008985	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590008986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590008987	exodeoxyribonuclease X; Provisional; Region: PRK07983
435590008988	Transglycosylase; Region: Transgly; pfam00912
435590008989	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
435590008990	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
435590008991	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
435590008992	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
435590008993	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
435590008994	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
435590008995	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
435590008996	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
435590008997	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590008998	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
435590008999	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
435590009000	dimer interface [polypeptide binding]; other site
435590009001	active site
435590009002	glycine-pyridoxal phosphate binding site [chemical binding]; other site
435590009003	folate binding site [chemical binding]; other site
435590009004	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590009005	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
435590009006	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590009007	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
435590009008	ligand binding site [chemical binding]; other site
435590009009	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
435590009010	Transglycosylase; Region: Transgly; cl17702
435590009011	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
435590009012	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
435590009013	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
435590009014	active site
435590009015	catalytic residues [active]
435590009016	metal binding site [ion binding]; metal-binding site
435590009017	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590009018	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590009019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590009021	DNA binding residues [nucleotide binding]
435590009022	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590009023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590009024	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590009025	Predicted membrane protein [Function unknown]; Region: COG2860
435590009026	UPF0126 domain; Region: UPF0126; pfam03458
435590009027	UPF0126 domain; Region: UPF0126; pfam03458
435590009028	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590009029	active site
435590009030	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
435590009031	homodimer interface [polypeptide binding]; other site
435590009032	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
435590009033	CTP synthetase; Validated; Region: pyrG; PRK05380
435590009034	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
435590009035	Catalytic site [active]
435590009036	active site
435590009037	UTP binding site [chemical binding]; other site
435590009038	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
435590009039	active site
435590009040	putative oxyanion hole; other site
435590009041	catalytic triad [active]
435590009042	membrane protein insertase; Provisional; Region: PRK01318
435590009043	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
435590009044	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590009045	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
435590009046	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590009047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
435590009048	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590009049	RNA binding surface [nucleotide binding]; other site
435590009050	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
435590009051	active site
435590009052	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
435590009053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009054	S-adenosylmethionine binding site [chemical binding]; other site
435590009055	pyruvate phosphate dikinase; Provisional; Region: PRK09279
435590009056	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590009057	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590009058	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
435590009059	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
435590009060	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
435590009061	active site
435590009062	catalytic residues [active]
435590009063	DNA binding site [nucleotide binding]
435590009064	Int/Topo IB signature motif; other site
435590009065	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
435590009066	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
435590009067	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
435590009068	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590009069	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590009070	P-loop; other site
435590009071	Magnesium ion binding site [ion binding]; other site
435590009072	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590009073	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590009074	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
435590009075	Walker A motif; other site
435590009076	ATP binding site [chemical binding]; other site
435590009077	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590009078	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590009079	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590009080	putative active site [active]
435590009081	putative NTP binding site [chemical binding]; other site
435590009082	putative nucleic acid binding site [nucleotide binding]; other site
435590009083	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590009084	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590009085	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590009086	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590009087	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590009088	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590009089	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
435590009090	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
435590009091	TraX protein; Region: TraX; pfam05857
435590009092	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590009093	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590009094	MutS domain I; Region: MutS_I; pfam01624
435590009095	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
435590009096	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
435590009097	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
435590009098	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
435590009099	active site
435590009100	metal binding site [ion binding]; metal-binding site
435590009101	interdomain interaction site; other site
435590009102	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
435590009103	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
435590009104	PcfK-like protein; Region: PcfK; pfam14058
435590009105	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
435590009106	PcfJ-like protein; Region: PcfJ; pfam14284
435590009107	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590009108	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590009109	P-loop; other site
435590009110	Magnesium ion binding site [ion binding]; other site
435590009111	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590009112	Magnesium ion binding site [ion binding]; other site
435590009113	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590009114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590009115	active site
435590009116	HIRAN domain; Region: HIRAN; pfam08797
435590009117	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590009118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590009119	active site
435590009120	motif I; other site
435590009121	motif II; other site
435590009122	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
435590009123	DNA protecting protein DprA; Region: dprA; TIGR00732
435590009124	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
435590009125	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
435590009126	DNA binding site [nucleotide binding]
435590009127	AAA domain; Region: AAA_30; pfam13604
435590009128	Family description; Region: UvrD_C_2; pfam13538
435590009129	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
435590009130	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
435590009131	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009132	ATP binding site [chemical binding]; other site
435590009133	putative Mg++ binding site [ion binding]; other site
435590009134	Uncharacterized conserved protein [Function unknown]; Region: COG1479
435590009135	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590009136	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590009137	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
435590009138	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590009139	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009140	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009141	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590009142	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590009143	Methyltransferase domain; Region: Methyltransf_26; pfam13659
435590009144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009145	non-specific DNA binding site [nucleotide binding]; other site
435590009146	salt bridge; other site
435590009147	sequence-specific DNA binding site [nucleotide binding]; other site
435590009148	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009149	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590009150	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
435590009151	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
435590009152	Catalytic site [active]
435590009153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009154	non-specific DNA binding site [nucleotide binding]; other site
435590009155	salt bridge; other site
435590009156	sequence-specific DNA binding site [nucleotide binding]; other site
435590009157	HNH endonuclease; Region: HNH_3; pfam13392
435590009158	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590009159	IHF - DNA interface [nucleotide binding]; other site
435590009160	IHF dimer interface [polypeptide binding]; other site
435590009161	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590009162	Divergent AAA domain; Region: AAA_4; pfam04326
435590009163	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590009164	HTH domain; Region: HTH_11; pfam08279
435590009165	CHC2 zinc finger; Region: zf-CHC2; pfam01807
435590009166	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
435590009167	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
435590009168	active site
435590009169	metal binding site [ion binding]; metal-binding site
435590009170	interdomain interaction site; other site
435590009171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009172	non-specific DNA binding site [nucleotide binding]; other site
435590009173	salt bridge; other site
435590009174	sequence-specific DNA binding site [nucleotide binding]; other site
435590009175	Peptidase C26; Region: Peptidase_C26; pfam07722
435590009176	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
435590009177	catalytic triad [active]
435590009178	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
435590009179	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
435590009180	active site
435590009181	dimer interface [polypeptide binding]; other site
435590009182	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009183	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
435590009184	FtsX-like permease family; Region: FtsX; pfam02687
435590009185	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009186	FtsX-like permease family; Region: FtsX; pfam02687
435590009187	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590009188	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590009189	Walker A/P-loop; other site
435590009190	ATP binding site [chemical binding]; other site
435590009191	Q-loop/lid; other site
435590009192	ABC transporter signature motif; other site
435590009193	Walker B; other site
435590009194	D-loop; other site
435590009195	H-loop/switch region; other site
435590009196	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009197	FtsX-like permease family; Region: FtsX; pfam02687
435590009198	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009199	FtsX-like permease family; Region: FtsX; pfam02687
435590009200	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590009201	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590009202	active site
435590009203	Zn binding site [ion binding]; other site
435590009204	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
435590009205	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590009206	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590009207	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590009208	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590009209	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
435590009210	putative ADP-binding pocket [chemical binding]; other site
435590009211	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
435590009212	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
435590009213	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590009214	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590009215	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590009216	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590009217	active site
435590009218	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
435590009219	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590009220	trimer interface [polypeptide binding]; other site
435590009221	active site
435590009222	substrate binding site [chemical binding]; other site
435590009223	CoA binding site [chemical binding]; other site
435590009224	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
435590009225	GDP-Fucose binding site [chemical binding]; other site
435590009226	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
435590009227	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590009228	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590009229	active site
435590009230	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590009231	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590009232	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590009233	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
435590009234	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
435590009235	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009236	non-specific DNA binding site [nucleotide binding]; other site
435590009237	salt bridge; other site
435590009238	sequence-specific DNA binding site [nucleotide binding]; other site
435590009239	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
435590009240	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
435590009241	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
435590009242	catalytic residues [active]
435590009243	dimer interface [polypeptide binding]; other site
435590009244	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590009245	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590009246	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590009247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009248	active site
435590009249	phosphorylation site [posttranslational modification]
435590009250	intermolecular recognition site; other site
435590009251	dimerization interface [polypeptide binding]; other site
435590009252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009253	Walker A motif; other site
435590009254	ATP binding site [chemical binding]; other site
435590009255	Walker B motif; other site
435590009256	arginine finger; other site
435590009257	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590009258	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
435590009259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590009260	ATP binding site [chemical binding]; other site
435590009261	Mg2+ binding site [ion binding]; other site
435590009262	G-X-G motif; other site
435590009263	Part of AAA domain; Region: AAA_19; pfam13245
435590009264	putative recombination protein RecB; Provisional; Region: PRK13909
435590009265	Family description; Region: UvrD_C_2; pfam13538
435590009266	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
435590009267	probable DNA repair protein; Region: TIGR03623
435590009268	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
435590009269	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
435590009270	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
435590009271	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
435590009272	replicative DNA helicase; Region: DnaB; TIGR00665
435590009273	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
435590009274	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
435590009275	Walker A motif; other site
435590009276	ATP binding site [chemical binding]; other site
435590009277	Walker B motif; other site
435590009278	DNA binding loops [nucleotide binding]
435590009279	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
435590009280	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
435590009281	putative tRNA-binding site [nucleotide binding]; other site
435590009282	B3/4 domain; Region: B3_4; pfam03483
435590009283	tRNA synthetase B5 domain; Region: B5; smart00874
435590009284	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
435590009285	dimer interface [polypeptide binding]; other site
435590009286	motif 1; other site
435590009287	motif 3; other site
435590009288	motif 2; other site
435590009289	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
435590009290	hypothetical protein; Provisional; Region: PRK12378
435590009291	TSCPD domain; Region: TSCPD; cl14834
435590009292	transposase/IS protein; Provisional; Region: PRK09183
435590009293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009294	Walker A motif; other site
435590009295	ATP binding site [chemical binding]; other site
435590009296	Walker B motif; other site
435590009297	arginine finger; other site
435590009298	Homeodomain-like domain; Region: HTH_23; pfam13384
435590009299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590009300	Integrase core domain; Region: rve; pfam00665
435590009301	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
435590009302	Walker A motif; other site
435590009303	ATP binding site [chemical binding]; other site
435590009304	Walker B motif; other site
435590009305	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
435590009306	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
435590009307	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
435590009308	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590009309	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
435590009310	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590009311	Magnesium ion binding site [ion binding]; other site
435590009312	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590009313	C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121
435590009314	Fic family protein [Function unknown]; Region: COG3177
435590009315	Fic/DOC family; Region: Fic; pfam02661
435590009316	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590009317	Competence protein CoiA-like family; Region: CoiA; cl11541
435590009318	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590009319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
435590009320	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590009321	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590009322	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590009323	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590009324	SusD family; Region: SusD; pfam07980
435590009325	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590009326	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590009327	ligand binding site [chemical binding]; other site
435590009328	flexible hinge region; other site
435590009329	transposase/IS protein; Provisional; Region: PRK09183
435590009330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009331	Walker A motif; other site
435590009332	ATP binding site [chemical binding]; other site
435590009333	Walker B motif; other site
435590009334	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
435590009335	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590009336	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
435590009337	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
435590009338	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590009339	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590009340	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590009341	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590009342	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590009343	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590009344	Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112
435590009345	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
435590009346	active site
435590009347	dimer interface [polypeptide binding]; other site
435590009348	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
435590009349	putative active site [active]
435590009350	exopolyphosphatase; Region: exo_poly_only; TIGR03706
435590009351	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
435590009352	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
435590009353	active site
435590009354	dimer interfaces [polypeptide binding]; other site
435590009355	catalytic residues [active]
435590009356	Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010
435590009357	active site
435590009358	metal binding site [ion binding]; metal-binding site
435590009359	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
435590009360	putative homodimer interface [polypeptide binding]; other site
435590009361	putative active site pocket [active]
435590009362	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
435590009363	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
435590009364	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590009365	TrkA-C domain; Region: TrkA_C; pfam02080
435590009366	TrkA-C domain; Region: TrkA_C; pfam02080
435590009367	6-phosphofructokinase; Provisional; Region: PRK03202
435590009368	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
435590009369	active site
435590009370	ADP/pyrophosphate binding site [chemical binding]; other site
435590009371	dimerization interface [polypeptide binding]; other site
435590009372	allosteric effector site; other site
435590009373	fructose-1,6-bisphosphate binding site; other site
435590009374	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
435590009375	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009376	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
435590009377	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590009378	putative dimer interface [polypeptide binding]; other site
435590009379	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590009380	catalytic core [active]
435590009381	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590009382	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
435590009383	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
435590009384	putative active site; other site
435590009385	catalytic residue [active]
435590009386	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
435590009387	Ferritin-like domain; Region: Ferritin; pfam00210
435590009388	ferroxidase diiron center [ion binding]; other site
435590009389	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
435590009390	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
435590009391	dinuclear metal binding motif [ion binding]; other site
435590009392	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009393	FtsX-like permease family; Region: FtsX; pfam02687
435590009394	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009395	FtsX-like permease family; Region: FtsX; pfam02687
435590009396	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590009397	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
435590009398	Walker A/P-loop; other site
435590009399	ATP binding site [chemical binding]; other site
435590009400	Q-loop/lid; other site
435590009401	ABC transporter signature motif; other site
435590009402	Walker B; other site
435590009403	D-loop; other site
435590009404	H-loop/switch region; other site
435590009405	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009406	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590009407	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590009408	Outer membrane efflux protein; Region: OEP; pfam02321
435590009409	Outer membrane efflux protein; Region: OEP; pfam02321
435590009410	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590009411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009412	active site
435590009413	phosphorylation site [posttranslational modification]
435590009414	intermolecular recognition site; other site
435590009415	dimerization interface [polypeptide binding]; other site
435590009416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009417	Walker A motif; other site
435590009418	ATP binding site [chemical binding]; other site
435590009419	Walker B motif; other site
435590009420	arginine finger; other site
435590009421	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
435590009422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
435590009423	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
435590009424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590009425	ATP binding site [chemical binding]; other site
435590009426	Mg2+ binding site [ion binding]; other site
435590009427	G-X-G motif; other site
435590009428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590009429	Coenzyme A binding pocket [chemical binding]; other site
435590009430	Predicted amidohydrolase [General function prediction only]; Region: COG0388
435590009431	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
435590009432	putative active site [active]
435590009433	catalytic triad [active]
435590009434	putative dimer interface [polypeptide binding]; other site
435590009435	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
435590009436	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
435590009437	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590009438	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
435590009439	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
435590009440	dimer interface [polypeptide binding]; other site
435590009441	active site
435590009442	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590009443	catalytic residues [active]
435590009444	substrate binding site [chemical binding]; other site
435590009445	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
435590009446	Part of AAA domain; Region: AAA_19; pfam13245
435590009447	Family description; Region: UvrD_C_2; pfam13538
435590009448	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
435590009449	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
435590009450	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
435590009451	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
435590009452	thiS-thiF/thiG interaction site; other site
435590009453	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
435590009454	thiamine phosphate binding site [chemical binding]; other site
435590009455	active site
435590009456	pyrophosphate binding site [ion binding]; other site
435590009457	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
435590009458	ThiS interaction site; other site
435590009459	putative active site [active]
435590009460	tetramer interface [polypeptide binding]; other site
435590009461	ThiC-associated domain; Region: ThiC-associated; pfam13667
435590009462	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
435590009463	ThiC family; Region: ThiC; pfam01964
435590009464	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
435590009465	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
435590009466	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
435590009467	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590009468	FeS/SAM binding site; other site
435590009469	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
435590009470	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
435590009471	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
435590009472	ATP binding site [chemical binding]; other site
435590009473	substrate interface [chemical binding]; other site
435590009474	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
435590009475	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
435590009476	thiamine phosphate binding site [chemical binding]; other site
435590009477	active site
435590009478	pyrophosphate binding site [ion binding]; other site
435590009479	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
435590009480	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
435590009481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590009482	active site
435590009483	Transposase domain (DUF772); Region: DUF772; pfam05598
435590009484	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590009485	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
435590009486	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
435590009487	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
435590009488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009489	dimer interface [polypeptide binding]; other site
435590009490	conserved gate region; other site
435590009491	putative PBP binding loops; other site
435590009492	ABC-ATPase subunit interface; other site
435590009493	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
435590009494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009495	dimer interface [polypeptide binding]; other site
435590009496	conserved gate region; other site
435590009497	putative PBP binding loops; other site
435590009498	ABC-ATPase subunit interface; other site
435590009499	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
435590009500	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
435590009501	Walker A/P-loop; other site
435590009502	ATP binding site [chemical binding]; other site
435590009503	Q-loop/lid; other site
435590009504	ABC transporter signature motif; other site
435590009505	Walker B; other site
435590009506	D-loop; other site
435590009507	H-loop/switch region; other site
435590009508	TOBE domain; Region: TOBE_2; pfam08402
435590009509	TOBE domain; Region: TOBE_2; pfam08402
435590009510	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590009511	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590009512	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590009513	catalytic residues [active]
435590009514	Transposase domain (DUF772); Region: DUF772; pfam05598
435590009515	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590009516	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
435590009517	putative homodimer interface [polypeptide binding]; other site
435590009518	putative active site pocket [active]
435590009519	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
435590009520	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590009521	Glycogen synthase; Region: Glycogen_syn; pfam05693
435590009522	V-type ATP synthase subunit K; Validated; Region: PRK08344
435590009523	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
435590009524	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
435590009525	V-type ATP synthase subunit I; Validated; Region: PRK05771
435590009526	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
435590009527	V-type ATP synthase subunit D; Provisional; Region: PRK02195
435590009528	V-type ATP synthase subunit B; Provisional; Region: PRK02118
435590009529	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
435590009530	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
435590009531	Walker A motif homologous position; other site
435590009532	Walker B motif; other site
435590009533	V-type ATP synthase subunit A; Provisional; Region: PRK04192
435590009534	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
435590009535	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
435590009536	Walker A motif/ATP binding site; other site
435590009537	Walker B motif; other site
435590009538	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
435590009539	V-type ATP synthase subunit E; Provisional; Region: PRK01558
435590009540	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
435590009541	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590009542	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
435590009543	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590009544	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590009545	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590009546	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
435590009547	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590009548	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590009549	Outer membrane efflux protein; Region: OEP; pfam02321
435590009550	Outer membrane efflux protein; Region: OEP; pfam02321
435590009551	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
435590009552	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
435590009553	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590009554	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590009555	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590009556	ligand binding site [chemical binding]; other site
435590009557	flexible hinge region; other site
435590009558	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
435590009559	putative switch regulator; other site
435590009560	non-specific DNA interactions [nucleotide binding]; other site
435590009561	DNA binding site [nucleotide binding]
435590009562	sequence specific DNA binding site [nucleotide binding]; other site
435590009563	putative cAMP binding site [chemical binding]; other site
435590009564	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
435590009565	Ferritin-like domain; Region: Ferritin; pfam00210
435590009566	diiron binding motif [ion binding]; other site
435590009567	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
435590009568	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
435590009569	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
435590009570	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
435590009571	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
435590009572	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
435590009573	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
435590009574	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
435590009575	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
435590009576	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
435590009577	GMP synthase; Reviewed; Region: guaA; PRK00074
435590009578	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
435590009579	AMP/PPi binding site [chemical binding]; other site
435590009580	candidate oxyanion hole; other site
435590009581	catalytic triad [active]
435590009582	potential glutamine specificity residues [chemical binding]; other site
435590009583	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
435590009584	ATP Binding subdomain [chemical binding]; other site
435590009585	Ligand Binding sites [chemical binding]; other site
435590009586	Dimerization subdomain; other site
435590009587	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590009588	GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519
435590009589	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
435590009590	ATP Binding subdomain [chemical binding]; other site
435590009591	Ligand Binding sites [chemical binding]; other site
435590009592	Dimerization subdomain; other site
435590009593	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
435590009594	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
435590009595	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
435590009596	active site
435590009597	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009598	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
435590009599	E3 interaction surface; other site
435590009600	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590009601	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590009602	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590009603	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009604	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590009605	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590009606	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590009607	Outer membrane efflux protein; Region: OEP; pfam02321
435590009608	Outer membrane efflux protein; Region: OEP; pfam02321
435590009609	Histidine kinase; Region: His_kinase; pfam06580
435590009610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009611	Response regulator receiver domain; Region: Response_reg; pfam00072
435590009612	active site
435590009613	phosphorylation site [posttranslational modification]
435590009614	intermolecular recognition site; other site
435590009615	dimerization interface [polypeptide binding]; other site
435590009616	LytTr DNA-binding domain; Region: LytTR; smart00850
435590009617	Proline dehydrogenase; Region: Pro_dh; cl03282
435590009618	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
435590009619	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
435590009620	Glutamate binding site [chemical binding]; other site
435590009621	NAD binding site [chemical binding]; other site
435590009622	catalytic residues [active]
435590009623	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
435590009624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590009625	Walker A/P-loop; other site
435590009626	ATP binding site [chemical binding]; other site
435590009627	ABC transporter; Region: ABC_tran; pfam00005
435590009628	Q-loop/lid; other site
435590009629	ABC transporter signature motif; other site
435590009630	Walker B; other site
435590009631	D-loop; other site
435590009632	H-loop/switch region; other site
435590009633	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
435590009634	RNA methyltransferase, RsmE family; Region: TIGR00046
435590009635	Bifunctional nuclease; Region: DNase-RNase; pfam02577
435590009636	UvrB/uvrC motif; Region: UVR; pfam02151
435590009637	nucleoside transporter; Region: 2A0110; TIGR00889
435590009638	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590009639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590009641	DNA binding residues [nucleotide binding]
435590009642	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590009643	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009644	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590009645	DNA binding residues [nucleotide binding]
435590009646	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590009647	Methyltransferase domain; Region: Methyltransf_23; pfam13489
435590009648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009649	S-adenosylmethionine binding site [chemical binding]; other site
435590009650	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
435590009651	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
435590009652	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
435590009653	putative RNA binding site [nucleotide binding]; other site
435590009654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009655	S-adenosylmethionine binding site [chemical binding]; other site
435590009656	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
435590009657	catalytic site [active]
435590009658	putative active site [active]
435590009659	putative substrate binding site [chemical binding]; other site
435590009660	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
435590009661	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
435590009662	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
435590009663	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
435590009664	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
435590009665	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
435590009666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
435590009667	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590009668	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590009669	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590009670	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590009671	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590009672	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590009673	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
435590009674	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
435590009675	Walker A/P-loop; other site
435590009676	ATP binding site [chemical binding]; other site
435590009677	Q-loop/lid; other site
435590009678	ABC transporter signature motif; other site
435590009679	Walker B; other site
435590009680	D-loop; other site
435590009681	H-loop/switch region; other site
435590009682	NlpC/P60 family; Region: NLPC_P60; pfam00877
435590009683	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590009684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590009685	motif II; other site
435590009686	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
435590009687	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
435590009688	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
435590009689	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
435590009690	Thiamine pyrophosphokinase; Region: TPK; cd07995
435590009691	active site
435590009692	dimerization interface [polypeptide binding]; other site
435590009693	thiamine binding site [chemical binding]; other site
435590009694	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
435590009695	seryl-tRNA synthetase; Provisional; Region: PRK05431
435590009696	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
435590009697	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
435590009698	dimer interface [polypeptide binding]; other site
435590009699	active site
435590009700	motif 1; other site
435590009701	motif 2; other site
435590009702	motif 3; other site
435590009703	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590009704	L-fucose transporter; Provisional; Region: PRK10133; cl17665
435590009705	L-fucose transporter; Provisional; Region: PRK10133; cl17665
435590009706	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
435590009707	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
435590009708	FAD binding pocket [chemical binding]; other site
435590009709	FAD binding motif [chemical binding]; other site
435590009710	phosphate binding motif [ion binding]; other site
435590009711	beta-alpha-beta structure motif; other site
435590009712	NAD binding pocket [chemical binding]; other site
435590009713	Iron coordination center [ion binding]; other site
435590009714	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
435590009715	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590009716	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
435590009717	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
435590009718	Ligand Binding Site [chemical binding]; other site
435590009719	TIGR00269 family protein; Region: TIGR00269
435590009720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590009721	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
435590009722	TPR motif; other site
435590009723	binding surface
435590009724	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590009725	hypothetical protein; Provisional; Region: PRK13665
435590009726	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
435590009727	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
435590009728	GAF domain; Region: GAF_2; pfam13185
435590009729	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
435590009730	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
435590009731	trmE is a tRNA modification GTPase; Region: trmE; cd04164
435590009732	G1 box; other site
435590009733	GTP/Mg2+ binding site [chemical binding]; other site
435590009734	Switch I region; other site
435590009735	G2 box; other site
435590009736	Switch II region; other site
435590009737	G3 box; other site
435590009738	G4 box; other site
435590009739	G5 box; other site
435590009740	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
435590009741	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
435590009742	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
435590009743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590009744	AAA domain; Region: AAA_21; pfam13304
435590009745	Walker A/P-loop; other site
435590009746	ATP binding site [chemical binding]; other site
435590009747	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
435590009748	Abi-like protein; Region: Abi_2; pfam07751
435590009749	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009750	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009751	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009752	TIR domain; Region: TIR_2; pfam13676
435590009753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
435590009754	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
435590009755	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
435590009756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
435590009757	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
435590009758	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
435590009759	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
435590009760	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
435590009761	RloB-like protein; Region: RloB; pfam13707
435590009762	AAA domain; Region: AAA_21; pfam13304
435590009763	RloB-like protein; Region: RloB; pfam13707
435590009764	Predicted ATPases [General function prediction only]; Region: COG1106
435590009765	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590009766	Walker A/P-loop; other site
435590009767	ATP binding site [chemical binding]; other site
435590009768	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
435590009769	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
435590009770	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
435590009771	Int/Topo IB signature motif; other site
435590009772	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590009773	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009774	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009775	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590009776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590009777	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590009778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
435590009779	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
435590009780	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590009781	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590009782	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009783	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590009784	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009785	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009786	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590009787	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009788	Virulence protein [General function prediction only]; Region: COG3943
435590009789	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590009790	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
435590009791	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590009792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009793	S-adenosylmethionine binding site [chemical binding]; other site
435590009794	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
435590009795	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
435590009796	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
435590009797	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009798	ATP binding site [chemical binding]; other site
435590009799	putative Mg++ binding site [ion binding]; other site
435590009800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009801	non-specific DNA binding site [nucleotide binding]; other site
435590009802	salt bridge; other site
435590009803	sequence-specific DNA binding site [nucleotide binding]; other site
435590009804	HipA-like N-terminal domain; Region: HipA_N; pfam07805
435590009805	HipA-like C-terminal domain; Region: HipA_C; pfam07804
435590009806	HipA N-terminal domain; Region: couple_hipA; TIGR03071
435590009807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009808	non-specific DNA binding site [nucleotide binding]; other site
435590009809	salt bridge; other site
435590009810	sequence-specific DNA binding site [nucleotide binding]; other site
435590009811	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009812	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590009813	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590009814	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590009815	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
435590009816	ParB-like nuclease domain; Region: ParBc; pfam02195
435590009817	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
435590009818	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590009819	Active Sites [active]
435590009820	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
435590009821	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590009822	starch binding outer membrane protein SusD; Region: SusD; cl17845
435590009823	SusD family; Region: SusD; pfam07980
435590009824	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590009825	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590009826	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590009827	Uncharacterized protein conserved in Bacteroidetes; Region: DUF4425; cd11379
435590009828	dimer interface [polypeptide binding]; other site
435590009829	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590009830	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590009831	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
435590009832	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590009833	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590009834	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
435590009835	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590009836	SusD family; Region: SusD; pfam07980
435590009837	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590009838	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
435590009839	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009840	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
435590009841	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009842	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590009843	Int/Topo IB signature motif; other site
435590009844	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009845	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009846	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590009847	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590009848	active site
435590009849	Int/Topo IB signature motif; other site
435590009850	DNA binding site [nucleotide binding]
435590009851	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590009852	conserved cys residue [active]
435590009853	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
435590009854	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590009855	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009856	Helix-turn-helix domain; Region: HTH_17; pfam12728
435590009857	Virulence protein [General function prediction only]; Region: COG3943
435590009858	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009859	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590009860	Int/Topo IB signature motif; other site
435590009861	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009862	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590009863	Int/Topo IB signature motif; other site
435590009864	Helix-turn-helix domain; Region: HTH_17; cl17695
435590009865	Phage associated DNA primase [General function prediction only]; Region: COG3378
435590009866	Restriction endonuclease; Region: Mrr_cat; pfam04471
435590009867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009868	non-specific DNA binding site [nucleotide binding]; other site
435590009869	salt bridge; other site
435590009870	sequence-specific DNA binding site [nucleotide binding]; other site
435590009871	DNA methylase; Region: N6_N4_Mtase; cl17433
435590009872	DNA methylase; Region: N6_N4_Mtase; cl17433
435590009873	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590009874	Divergent AAA domain; Region: AAA_4; pfam04326
435590009875	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590009876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009877	ATP binding site [chemical binding]; other site
435590009878	putative Mg++ binding site [ion binding]; other site
435590009879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590009880	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
435590009881	nucleotide binding region [chemical binding]; other site
435590009882	ATP-binding site [chemical binding]; other site
435590009883	PglZ domain; Region: PglZ; pfam08665
435590009884	HIRAN domain; Region: HIRAN; cl07418
435590009885	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590009886	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590009887	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
435590009888	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009889	ATP binding site [chemical binding]; other site
435590009890	putative Mg++ binding site [ion binding]; other site
435590009891	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590009892	nucleotide binding region [chemical binding]; other site
435590009893	ATP-binding site [chemical binding]; other site
435590009894	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590009895	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
435590009896	FeS/SAM binding site; other site
435590009897	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
435590009898	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
435590009899	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
435590009900	oligomer interface [polypeptide binding]; other site
435590009901	active site
435590009902	metal binding site [ion binding]; metal-binding site
435590009903	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
435590009904	PLD-like domain; Region: PLDc_2; pfam13091
435590009905	putative homodimer interface [polypeptide binding]; other site
435590009906	putative active site [active]
435590009907	catalytic site [active]
435590009908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
435590009909	putative Mg++ binding site [ion binding]; other site
435590009910	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
435590009911	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
435590009912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
435590009913	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
435590009914	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
435590009915	putative efflux protein, MATE family; Region: matE; TIGR00797
435590009916	HipA N-terminal domain; Region: Couple_hipA; pfam13657
435590009917	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
435590009918	HipA-like N-terminal domain; Region: HipA_N; pfam07805
435590009919	HipA-like C-terminal domain; Region: HipA_C; pfam07804
435590009920	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
435590009921	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009922	non-specific DNA binding site [nucleotide binding]; other site
435590009923	salt bridge; other site
435590009924	sequence-specific DNA binding site [nucleotide binding]; other site
435590009925	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
435590009926	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
435590009927	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590009928	putative active site [active]
435590009929	putative metal binding site [ion binding]; other site
435590009930	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590009931	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
435590009932	putative active site [active]
435590009933	putative metal binding site [ion binding]; other site
435590009934	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
435590009935	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009936	non-specific DNA binding site [nucleotide binding]; other site
435590009937	salt bridge; other site
435590009938	sequence-specific DNA binding site [nucleotide binding]; other site
435590009939	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
435590009940	Transposase domain (DUF772); Region: DUF772; pfam05598
435590009941	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590009942	Homeodomain-like domain; Region: HTH_23; pfam13384
435590009943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590009944	Integrase core domain; Region: rve; pfam00665
435590009945	transcription elongation factor NusA-like protein; Validated; Region: PRK08406
435590009946	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
435590009947	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
435590009948	Formaldehyde dehydrogenases; Region: FDH_like; cd05278
435590009949	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
435590009950	catalytic Zn binding site [ion binding]; other site
435590009951	NAD(P) binding site [chemical binding]; other site
435590009952	structural Zn binding site [ion binding]; other site
435590009953	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
435590009954	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590009955	putative dimer interface [polypeptide binding]; other site
435590009956	Predicted membrane protein [Function unknown]; Region: COG2246
435590009957	GtrA-like protein; Region: GtrA; pfam04138
435590009958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009959	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
435590009960	NAD(P) binding site [chemical binding]; other site
435590009961	active site
435590009962	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
435590009963	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590009964	putative metal binding site [ion binding]; other site
435590009965	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
435590009966	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
435590009967	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
435590009968	putative active site [active]
435590009969	putative catalytic site [active]
435590009970	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
435590009971	Low molecular weight phosphatase family; Region: LMWPc; cl00105
435590009972	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
435590009973	active site
435590009974	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590009975	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
435590009976	active site
435590009977	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590009978	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
435590009979	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
435590009980	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
435590009981	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009982	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590009983	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590009984	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590009985	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590009986	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590009987	AAA domain; Region: AAA_14; pfam13173
435590009988	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
435590009989	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590009990	dimer interface [polypeptide binding]; other site
435590009991	PYR/PP interface [polypeptide binding]; other site
435590009992	TPP binding site [chemical binding]; other site
435590009993	substrate binding site [chemical binding]; other site
435590009994	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
435590009995	Domain of unknown function; Region: EKR; smart00890
435590009996	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590009997	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
435590009998	TPP-binding site [chemical binding]; other site
435590009999	dimer interface [polypeptide binding]; other site
435590010000	arylsulfatase; Provisional; Region: PRK13759
435590010001	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590010002	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590010003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
435590010004	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590010005	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
435590010006	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590010007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010008	active site
435590010009	phosphorylation site [posttranslational modification]
435590010010	intermolecular recognition site; other site
435590010011	dimerization interface [polypeptide binding]; other site
435590010012	LytTr DNA-binding domain; Region: LytTR; smart00850
435590010013	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590010014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590010015	binding surface
435590010016	TPR motif; other site
435590010017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010018	binding surface
435590010019	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590010020	TPR motif; other site
435590010021	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590010022	Histidine kinase; Region: His_kinase; pfam06580
435590010023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010024	ATP binding site [chemical binding]; other site
435590010025	Mg2+ binding site [ion binding]; other site
435590010026	G-X-G motif; other site
435590010027	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
435590010028	active site
435590010029	catalytic residues [active]
435590010030	EamA-like transporter family; Region: EamA; cl17759
435590010031	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
435590010032	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
435590010033	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
435590010034	active site
435590010035	substrate binding site [chemical binding]; other site
435590010036	metal binding site [ion binding]; metal-binding site
435590010037	Peptidase family C69; Region: Peptidase_C69; cl17793
435590010038	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
435590010039	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590010040	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
435590010041	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
435590010042	hexamer interface [polypeptide binding]; other site
435590010043	ligand binding site [chemical binding]; other site
435590010044	putative active site [active]
435590010045	NAD(P) binding site [chemical binding]; other site
435590010046	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
435590010047	Predicted membrane protein [Function unknown]; Region: COG3174
435590010048	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
435590010049	Predicted membrane protein [Function unknown]; Region: COG2855
435590010050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
435590010051	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
435590010052	putative dimerization interface [polypeptide binding]; other site
435590010053	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
435590010054	Clp amino terminal domain; Region: Clp_N; pfam02861
435590010055	Clp amino terminal domain; Region: Clp_N; pfam02861
435590010056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590010057	Walker A motif; other site
435590010058	ATP binding site [chemical binding]; other site
435590010059	Walker B motif; other site
435590010060	arginine finger; other site
435590010061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590010062	Walker A motif; other site
435590010063	ATP binding site [chemical binding]; other site
435590010064	Walker B motif; other site
435590010065	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
435590010066	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
435590010067	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
435590010068	CoA-binding site [chemical binding]; other site
435590010069	ATP-binding [chemical binding]; other site
435590010070	YbbR-like protein; Region: YbbR; pfam07949
435590010071	Preprotein translocase subunit; Region: YajC; pfam02699
435590010072	transcription antitermination factor NusB; Region: nusB; TIGR01951
435590010073	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
435590010074	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
435590010075	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
435590010076	5S rRNA interface [nucleotide binding]; other site
435590010077	CTC domain interface [polypeptide binding]; other site
435590010078	L16 interface [polypeptide binding]; other site
435590010079	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
435590010080	putative active site [active]
435590010081	catalytic residue [active]
435590010082	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590010083	RNA binding surface [nucleotide binding]; other site
435590010084	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
435590010085	nucleotide binding site/active site [active]
435590010086	HIT family signature motif; other site
435590010087	catalytic residue [active]
435590010088	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
435590010089	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590010090	TrkA-C domain; Region: TrkA_C; pfam02080
435590010091	TrkA-C domain; Region: TrkA_C; pfam02080
435590010092	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
435590010093	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
435590010094	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
435590010095	peptidase T; Region: peptidase-T; TIGR01882
435590010096	metal binding site [ion binding]; metal-binding site
435590010097	dimer interface [polypeptide binding]; other site
435590010098	amidophosphoribosyltransferase; Region: purF; TIGR01134
435590010099	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
435590010100	active site
435590010101	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590010102	active site
435590010103	camphor resistance protein CrcB; Provisional; Region: PRK14210
435590010104	NigD-like protein; Region: NigD; pfam12667
435590010105	Two component regulator propeller; Region: Reg_prop; pfam07494
435590010106	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590010107	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590010108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010109	dimer interface [polypeptide binding]; other site
435590010110	phosphorylation site [posttranslational modification]
435590010111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010112	ATP binding site [chemical binding]; other site
435590010113	Mg2+ binding site [ion binding]; other site
435590010114	G-X-G motif; other site
435590010115	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590010116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010117	active site
435590010118	phosphorylation site [posttranslational modification]
435590010119	intermolecular recognition site; other site
435590010120	dimerization interface [polypeptide binding]; other site
435590010121	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590010122	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
435590010123	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
435590010124	active site
435590010125	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590010126	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590010127	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590010128	pantothenate kinase; Provisional; Region: PRK13317
435590010129	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590010130	beta-D-glucuronidase; Provisional; Region: PRK10150
435590010131	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590010132	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590010133	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
435590010134	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590010135	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
435590010136	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
435590010137	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
435590010138	putative active site [active]
435590010139	putative substrate binding site [chemical binding]; other site
435590010140	putative cosubstrate binding site; other site
435590010141	catalytic site [active]
435590010142	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
435590010143	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
435590010144	putative active site [active]
435590010145	oxyanion strand; other site
435590010146	catalytic triad [active]
435590010147	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
435590010148	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
435590010149	catalytic residues [active]
435590010150	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
435590010151	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
435590010152	substrate binding site [chemical binding]; other site
435590010153	glutamase interaction surface [polypeptide binding]; other site
435590010154	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
435590010155	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
435590010156	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
435590010157	metal binding site [ion binding]; metal-binding site
435590010158	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
435590010159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590010160	Walker A/P-loop; other site
435590010161	ATP binding site [chemical binding]; other site
435590010162	Q-loop/lid; other site
435590010163	ABC transporter signature motif; other site
435590010164	Walker B; other site
435590010165	D-loop; other site
435590010166	H-loop/switch region; other site
435590010167	aspartate kinase III; Validated; Region: PRK09084
435590010168	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
435590010169	putative catalytic residues [active]
435590010170	nucleotide binding site [chemical binding]; other site
435590010171	aspartate binding site [chemical binding]; other site
435590010172	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
435590010173	dimer interface [polypeptide binding]; other site
435590010174	allosteric regulatory binding pocket; other site
435590010175	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
435590010176	dimer interface [polypeptide binding]; other site
435590010177	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
435590010178	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
435590010179	active site
435590010180	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590010181	substrate binding site [chemical binding]; other site
435590010182	catalytic residues [active]
435590010183	dimer interface [polypeptide binding]; other site
435590010184	Transposase domain (DUF772); Region: DUF772; pfam05598
435590010185	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590010186	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010187	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010188	active site
435590010189	Uncharacterized conserved protein [Function unknown]; Region: COG1359
435590010190	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
435590010191	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
435590010192	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590010193	FtsX-like permease family; Region: FtsX; pfam02687
435590010194	aspartate aminotransferase; Provisional; Region: PRK07568
435590010195	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590010196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010197	homodimer interface [polypeptide binding]; other site
435590010198	catalytic residue [active]
435590010199	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
435590010200	substrate binding site [chemical binding]; other site
435590010201	trimer interface [polypeptide binding]; other site
435590010202	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590010203	Mn binding site [ion binding]; other site
435590010204	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
435590010205	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590010206	catalytic residue [active]
435590010207	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
435590010208	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
435590010209	phosphate binding site [ion binding]; other site
435590010210	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590010211	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
435590010212	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
435590010213	acyl-activating enzyme (AAE) consensus motif; other site
435590010214	putative AMP binding site [chemical binding]; other site
435590010215	putative active site [active]
435590010216	putative CoA binding site [chemical binding]; other site
435590010217	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
435590010218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590010219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590010220	ligand binding site [chemical binding]; other site
435590010221	flexible hinge region; other site
435590010222	Peptidase family C69; Region: Peptidase_C69; cl17793
435590010223	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
435590010224	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590010225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
435590010226	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590010227	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
435590010228	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
435590010229	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
435590010230	Aspartase; Region: Aspartase; cd01357
435590010231	active sites [active]
435590010232	tetramer interface [polypeptide binding]; other site
435590010233	Uncharacterized conserved protein [Function unknown]; Region: COG1284
435590010234	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590010235	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590010236	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
435590010237	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
435590010238	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
435590010239	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
435590010240	NAD binding site [chemical binding]; other site
435590010241	homodimer interface [polypeptide binding]; other site
435590010242	active site
435590010243	substrate binding site [chemical binding]; other site
435590010244	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
435590010245	electron transport complex RsxE subunit; Provisional; Region: PRK12405
435590010246	FMN-binding domain; Region: FMN_bind; cl01081
435590010247	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
435590010248	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
435590010249	SLBB domain; Region: SLBB; pfam10531
435590010250	ferredoxin; Validated; Region: PRK07118
435590010251	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
435590010252	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
435590010253	threonine dehydratase; Provisional; Region: PRK08198
435590010254	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
435590010255	tetramer interface [polypeptide binding]; other site
435590010256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010257	catalytic residue [active]
435590010258	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
435590010259	EamA-like transporter family; Region: EamA; pfam00892
435590010260	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
435590010261	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590010262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590010263	putative substrate translocation pore; other site
435590010264	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
435590010265	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
435590010266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010267	catalytic residue [active]
435590010268	glutaminase; Reviewed; Region: PRK12356
435590010269	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
435590010270	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
435590010271	Transposase domain (DUF772); Region: DUF772; pfam05598
435590010272	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590010273	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
435590010274	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
435590010275	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
435590010276	Ion channel; Region: Ion_trans_2; pfam07885
435590010277	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
435590010278	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590010279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010280	dimer interface [polypeptide binding]; other site
435590010281	phosphorylation site [posttranslational modification]
435590010282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010283	ATP binding site [chemical binding]; other site
435590010284	Mg2+ binding site [ion binding]; other site
435590010285	G-X-G motif; other site
435590010286	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
435590010287	GTP-binding protein LepA; Provisional; Region: PRK05433
435590010288	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
435590010289	G1 box; other site
435590010290	putative GEF interaction site [polypeptide binding]; other site
435590010291	GTP/Mg2+ binding site [chemical binding]; other site
435590010292	Switch I region; other site
435590010293	G2 box; other site
435590010294	G3 box; other site
435590010295	Switch II region; other site
435590010296	G4 box; other site
435590010297	G5 box; other site
435590010298	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
435590010299	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
435590010300	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
435590010301	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
435590010302	Predicted ATPase [General function prediction only]; Region: COG4637
435590010303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
435590010304	ABC transporter signature motif; other site
435590010305	Walker B; other site
435590010306	D-loop; other site
435590010307	H-loop/switch region; other site
435590010308	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
435590010309	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
435590010310	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
435590010311	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
435590010312	putative ligand binding site [chemical binding]; other site
435590010313	putative NAD binding site [chemical binding]; other site
435590010314	catalytic site [active]
435590010315	recombination factor protein RarA; Reviewed; Region: PRK13342
435590010316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590010317	Walker A motif; other site
435590010318	ATP binding site [chemical binding]; other site
435590010319	Walker B motif; other site
435590010320	arginine finger; other site
435590010321	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
435590010322	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590010323	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590010324	amidase catalytic site [active]
435590010325	Zn binding residues [ion binding]; other site
435590010326	substrate binding site [chemical binding]; other site
435590010327	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
435590010328	active site
435590010329	metal binding site [ion binding]; metal-binding site
435590010330	interdomain interaction site; other site
435590010331	AAA domain; Region: AAA_25; pfam13481
435590010332	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
435590010333	Walker A motif; other site
435590010334	ATP binding site [chemical binding]; other site
435590010335	Walker B motif; other site
435590010336	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590010337	PIN domain; Region: PIN_3; pfam13470
435590010338	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590010339	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590010340	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010341	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590010342	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010343	active site
435590010344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010345	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590010346	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010347	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590010348	metal-binding site
435590010349	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
435590010350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010351	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590010352	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590010353	transcriptional activator RfaH; Region: RfaH; TIGR01955
435590010354	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
435590010355	KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739
435590010356	Protein of unknown function DUF86; Region: DUF86; cl01031
435590010357	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590010358	active site
435590010359	NTP binding site [chemical binding]; other site
435590010360	metal binding triad [ion binding]; metal-binding site
435590010361	antibiotic binding site [chemical binding]; other site
435590010362	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590010363	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
435590010364	PhoU domain; Region: PhoU; pfam01895
435590010365	PhoU domain; Region: PhoU; pfam01895
435590010366	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14245
435590010367	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
435590010368	Walker A/P-loop; other site
435590010369	ATP binding site [chemical binding]; other site
435590010370	Q-loop/lid; other site
435590010371	ABC transporter signature motif; other site
435590010372	Walker B; other site
435590010373	D-loop; other site
435590010374	H-loop/switch region; other site
435590010375	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
435590010376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590010377	dimer interface [polypeptide binding]; other site
435590010378	conserved gate region; other site
435590010379	putative PBP binding loops; other site
435590010380	ABC-ATPase subunit interface; other site
435590010381	PBP superfamily domain; Region: PBP_like_2; cl17296
435590010382	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
435590010383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590010384	dimer interface [polypeptide binding]; other site
435590010385	conserved gate region; other site
435590010386	putative PBP binding loops; other site
435590010387	ABC-ATPase subunit interface; other site
435590010388	PBP superfamily domain; Region: PBP_like_2; cl17296
435590010389	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
435590010390	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590010391	active site
435590010392	HIGH motif; other site
435590010393	nucleotide binding site [chemical binding]; other site
435590010394	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590010395	active site
435590010396	KMSKS motif; other site
435590010397	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
435590010398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010399	binding surface
435590010400	TPR motif; other site
435590010401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010402	binding surface
435590010403	TPR motif; other site
435590010404	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
435590010405	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
435590010406	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
435590010407	dimer interface [polypeptide binding]; other site
435590010408	catalytic triad [active]
435590010409	peroxidatic and resolving cysteines [active]
435590010410	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
435590010411	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
435590010412	NADP binding site [chemical binding]; other site
435590010413	active site
435590010414	putative substrate binding site [chemical binding]; other site
435590010415	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
435590010416	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
435590010417	NADP-binding site; other site
435590010418	homotetramer interface [polypeptide binding]; other site
435590010419	substrate binding site [chemical binding]; other site
435590010420	homodimer interface [polypeptide binding]; other site
435590010421	active site
435590010422	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590010423	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590010424	Substrate binding site; other site
435590010425	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
435590010426	Bacterial sugar transferase; Region: Bac_transf; pfam02397
435590010427	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
435590010428	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
435590010429	substrate binding site; other site
435590010430	tetramer interface; other site
435590010431	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
435590010432	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590010433	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590010434	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
435590010435	SLBB domain; Region: SLBB; pfam10531
435590010436	SLBB domain; Region: SLBB; pfam10531
435590010437	SLBB domain; Region: SLBB; pfam10531
435590010438	SLBB domain; Region: SLBB; pfam10531
435590010439	SLBB domain; Region: SLBB; pfam10531
435590010440	SLBB domain; Region: SLBB; pfam10531
435590010441	xylose isomerase; Provisional; Region: PRK05474
435590010442	xylose isomerase; Region: xylose_isom_A; TIGR02630
435590010443	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
435590010444	D-xylulose kinases, subgroup 2; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810
435590010445	putative N- and C-terminal domain interface [polypeptide binding]; other site
435590010446	putative active site [active]
435590010447	putative MgATP binding site [chemical binding]; other site
435590010448	catalytic site [active]
435590010449	metal binding site [ion binding]; metal-binding site
435590010450	putative xylulose binding site [chemical binding]; other site
435590010451	putative homodimer interface [polypeptide binding]; other site
435590010452	NUDIX domain; Region: NUDIX; pfam00293
435590010453	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
435590010454	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590010455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010456	active site
435590010457	phosphorylation site [posttranslational modification]
435590010458	intermolecular recognition site; other site
435590010459	dimerization interface [polypeptide binding]; other site
435590010460	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590010461	Outer membrane efflux protein; Region: OEP; pfam02321
435590010462	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590010463	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
435590010464	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010465	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590010466	Probable Catalytic site; other site
435590010467	metal-binding site
435590010468	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
435590010469	DXD motif; other site
435590010470	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010471	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
435590010472	DXD motif; other site
435590010473	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
435590010474	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590010475	trimer interface [polypeptide binding]; other site
435590010476	active site
435590010477	substrate binding site [chemical binding]; other site
435590010478	CoA binding site [chemical binding]; other site
435590010479	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
435590010480	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010481	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010482	active site
435590010483	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590010484	metal-binding site
435590010485	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
435590010486	GDP-Fucose binding site [chemical binding]; other site
435590010487	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296
435590010488	GDP-Fucose binding site [chemical binding]; other site
435590010489	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
435590010490	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
435590010491	Walker A/P-loop; other site
435590010492	ATP binding site [chemical binding]; other site
435590010493	Q-loop/lid; other site
435590010494	ABC transporter signature motif; other site
435590010495	Walker B; other site
435590010496	D-loop; other site
435590010497	H-loop/switch region; other site
435590010498	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
435590010499	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
435590010500	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010501	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010502	putative ADP-binding pocket [chemical binding]; other site
435590010503	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010504	active site
435590010505	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010506	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010507	active site
435590010508	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010509	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010510	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010511	putative ADP-binding pocket [chemical binding]; other site
435590010512	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010513	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010514	putative ADP-binding pocket [chemical binding]; other site
435590010515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010516	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590010517	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010518	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010519	putative ADP-binding pocket [chemical binding]; other site
435590010520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590010521	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010522	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010523	active site
435590010524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010525	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
435590010526	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
435590010527	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010528	DXD motif; other site
435590010529	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590010530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010531	active site
435590010532	phosphorylation site [posttranslational modification]
435590010533	intermolecular recognition site; other site
435590010534	dimerization interface [polypeptide binding]; other site
435590010535	PAS fold; Region: PAS; pfam00989
435590010536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590010537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010538	dimer interface [polypeptide binding]; other site
435590010539	phosphorylation site [posttranslational modification]
435590010540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010541	ATP binding site [chemical binding]; other site
435590010542	Mg2+ binding site [ion binding]; other site
435590010543	G-X-G motif; other site
435590010544	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
435590010545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010546	active site
435590010547	phosphorylation site [posttranslational modification]
435590010548	intermolecular recognition site; other site
435590010549	dimerization interface [polypeptide binding]; other site
435590010550	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
435590010551	putative catalytic site [active]
435590010552	putative metal binding site [ion binding]; other site
435590010553	putative phosphate binding site [ion binding]; other site
435590010554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010555	active site
435590010556	phosphorylation site [posttranslational modification]
435590010557	intermolecular recognition site; other site
435590010558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590010559	dimerization interface [polypeptide binding]; other site
435590010560	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010561	dimer interface [polypeptide binding]; other site
435590010562	phosphorylation site [posttranslational modification]
435590010563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010564	ATP binding site [chemical binding]; other site
435590010565	Mg2+ binding site [ion binding]; other site
435590010566	G-X-G motif; other site
435590010567	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590010568	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
435590010569	NAD binding site [chemical binding]; other site
435590010570	putative substrate binding site 2 [chemical binding]; other site
435590010571	putative substrate binding site 1 [chemical binding]; other site
435590010572	active site
435590010573	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
435590010574	dimer interface [polypeptide binding]; other site
435590010575	substrate binding site [chemical binding]; other site
435590010576	ATP binding site [chemical binding]; other site
435590010577	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
435590010578	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
435590010579	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
435590010580	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590010581	active site
435590010582	nucleophile elbow; other site
435590010583	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
435590010584	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
435590010585	active site
435590010586	catalytic site [active]
435590010587	HpaII restriction endonuclease; Region: RE_HpaII; pfam09561
435590010588	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
435590010589	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
435590010590	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
435590010591	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
435590010592	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590010593	putative dimer interface [polypeptide binding]; other site
435590010594	PAS fold; Region: PAS_4; pfam08448
435590010595	PAS domain; Region: PAS_9; pfam13426
435590010596	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
435590010597	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010598	dimer interface [polypeptide binding]; other site
435590010599	phosphorylation site [posttranslational modification]
435590010600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010601	ATP binding site [chemical binding]; other site
435590010602	Mg2+ binding site [ion binding]; other site
435590010603	G-X-G motif; other site
435590010604	Response regulator receiver domain; Region: Response_reg; pfam00072
435590010605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010606	active site
435590010607	phosphorylation site [posttranslational modification]
435590010608	intermolecular recognition site; other site
435590010609	dimerization interface [polypeptide binding]; other site
435590010610	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
435590010611	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590010612	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
435590010613	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
435590010614	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590010615	ATP-grasp domain; Region: ATP-grasp_4; cl17255
435590010616	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
435590010617	probable substrate binding site [chemical binding]; other site
435590010618	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
435590010619	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
435590010620	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
435590010621	catalytic site [active]
435590010622	subunit interface [polypeptide binding]; other site
435590010623	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
435590010624	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
435590010625	active site
435590010626	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
435590010627	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
435590010628	glutaminase active site [active]
435590010629	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
435590010630	dimer interface [polypeptide binding]; other site
435590010631	active site
435590010632	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
435590010633	dimer interface [polypeptide binding]; other site
435590010634	active site
435590010635	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
435590010636	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
435590010637	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590010638	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
435590010639	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
435590010640	Nitrogen regulatory protein P-II; Region: P-II; smart00938
435590010641	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
435590010642	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
435590010643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590010644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010645	homodimer interface [polypeptide binding]; other site
435590010646	catalytic residue [active]
435590010647	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
435590010648	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
435590010649	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
435590010650	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
435590010651	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
435590010652	active site
435590010653	dimer interface [polypeptide binding]; other site
435590010654	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
435590010655	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
435590010656	active site
435590010657	FMN binding site [chemical binding]; other site
435590010658	substrate binding site [chemical binding]; other site
435590010659	3Fe-4S cluster binding site [ion binding]; other site
435590010660	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
435590010661	domain interface; other site
435590010662	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
435590010663	asparagine synthetase B; Provisional; Region: asnB; PRK09431
435590010664	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
435590010665	active site
435590010666	dimer interface [polypeptide binding]; other site
435590010667	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
435590010668	Ligand Binding Site [chemical binding]; other site
435590010669	Molecular Tunnel; other site
435590010670	Transposase domain (DUF772); Region: DUF772; pfam05598
435590010671	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
435590010672	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
435590010673	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590010674	ATP binding site [chemical binding]; other site
435590010675	putative Mg++ binding site [ion binding]; other site
435590010676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590010677	nucleotide binding region [chemical binding]; other site
435590010678	ATP-binding site [chemical binding]; other site
435590010679	HEPN domain; Region: HEPN; cl00824
435590010680	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590010681	active site
435590010682	NTP binding site [chemical binding]; other site
435590010683	metal binding triad [ion binding]; metal-binding site
435590010684	antibiotic binding site [chemical binding]; other site
435590010685	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590010686	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590010687	extended (e) SDRs; Region: SDR_e; cd08946
435590010688	NAD(P) binding site [chemical binding]; other site
435590010689	active site
435590010690	substrate binding site [chemical binding]; other site
435590010691	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010692	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
435590010693	putative ADP-binding pocket [chemical binding]; other site
435590010694	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010695	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590010696	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
435590010697	chromosome segregation protein; Provisional; Region: PRK02224
435590010698	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
435590010699	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010700	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010701	active site
435590010702	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
435590010703	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
435590010704	inhibitor-cofactor binding pocket; inhibition site
435590010705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010706	catalytic residue [active]
435590010707	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
435590010708	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
435590010709	substrate binding site; other site
435590010710	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
435590010711	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
435590010712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010713	NAD(P) binding site [chemical binding]; other site
435590010714	active site
435590010715	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
435590010716	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590010717	catalytic residue [active]
435590010718	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
435590010719	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590010720	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590010721	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
435590010722	active site
435590010723	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
435590010724	active site
435590010725	catalytic residues [active]
435590010726	metal binding site [ion binding]; metal-binding site
435590010727	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
435590010728	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
435590010729	Ligand binding site; other site
435590010730	oligomer interface; other site
435590010731	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
435590010732	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
435590010733	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
435590010734	Substrate binding site; other site
435590010735	metal-binding site
435590010736	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
435590010737	ligand binding site; other site
435590010738	tetramer interface; other site
435590010739	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
435590010740	NeuB family; Region: NeuB; pfam03102
435590010741	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
435590010742	NeuB binding interface [polypeptide binding]; other site
435590010743	putative substrate binding site [chemical binding]; other site
435590010744	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
435590010745	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
435590010746	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
435590010747	diaminopimelate decarboxylase; Region: lysA; TIGR01048
435590010748	dimer interface [polypeptide binding]; other site
435590010749	active site
435590010750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590010751	catalytic residues [active]
435590010752	substrate binding site [chemical binding]; other site
435590010753	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
435590010754	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590010755	active site
435590010756	homodimer interface [polypeptide binding]; other site
435590010757	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
435590010758	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
435590010759	inhibitor-cofactor binding pocket; inhibition site
435590010760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010761	catalytic residue [active]
435590010762	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010763	NAD(P) binding site [chemical binding]; other site
435590010764	active site
435590010765	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590010766	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590010767	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590010768	amidase catalytic site [active]
435590010769	Zn binding residues [ion binding]; other site
435590010770	substrate binding site [chemical binding]; other site
435590010771	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
435590010772	putative ligand binding site [chemical binding]; other site
435590010773	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
435590010774	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
435590010775	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590010776	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
435590010777	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
435590010778	active site
435590010779	substrate binding site [chemical binding]; other site
435590010780	Mg2+ binding site [ion binding]; other site
435590010781	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
435590010782	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
435590010783	YceG-like family; Region: YceG; pfam02618
435590010784	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
435590010785	dimerization interface [polypeptide binding]; other site
435590010786	Flavodoxin domain; Region: Flavodoxin_5; cl17428
435590010787	4Fe-4S binding domain; Region: Fer4; pfam00037
435590010788	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
435590010789	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
435590010790	23S rRNA binding site [nucleotide binding]; other site
435590010791	L21 binding site [polypeptide binding]; other site
435590010792	L13 binding site [polypeptide binding]; other site
435590010793	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
435590010794	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
435590010795	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
435590010796	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
435590010797	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
435590010798	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
435590010799	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
435590010800	active site
435590010801	dimer interface [polypeptide binding]; other site
435590010802	motif 1; other site
435590010803	motif 2; other site
435590010804	motif 3; other site
435590010805	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
435590010806	anticodon binding site; other site
435590010807	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010808	TPR motif; other site
435590010809	binding surface
435590010810	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
435590010811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010812	TPR motif; other site
435590010813	binding surface
435590010814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010815	binding surface
435590010816	TPR motif; other site
435590010817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010818	binding surface
435590010819	TPR motif; other site
435590010820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010821	binding surface
435590010822	TPR motif; other site
435590010823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010824	TPR motif; other site
435590010825	TPR repeat; Region: TPR_11; pfam13414
435590010826	binding surface
435590010827	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
435590010828	active site
435590010829	catalytic residues [active]
435590010830	metal binding site [ion binding]; metal-binding site
435590010831	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
435590010832	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590010833	Domain of unknown function (DUF3869); Region: DUF3869; pfam12985
435590010834	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
435590010835	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
435590010836	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590010837	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
435590010838	ligand binding site [chemical binding]; other site
435590010839	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
435590010840	Sporulation related domain; Region: SPOR; pfam05036
435590010841	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590010842	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010843	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010844	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010845	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590010846	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590010847	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590010848	protein binding site [polypeptide binding]; other site
435590010849	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590010850	Domain interface; other site
435590010851	Peptide binding site; other site
435590010852	Active site tetrad [active]
435590010853	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
435590010854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590010855	putative substrate translocation pore; other site
435590010856	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
435590010857	Sulfatase; Region: Sulfatase; pfam00884
435590010858	Surface antigen; Region: Bac_surface_Ag; pfam01103
435590010859	Outer membrane efflux protein; Region: OEP; pfam02321
435590010860	Outer membrane efflux protein; Region: OEP; pfam02321
435590010861	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590010862	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590010863	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590010864	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590010865	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590010866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590010867	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590010868	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590010869	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
435590010870	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
435590010871	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
435590010872	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
435590010873	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010874	catalytic residue [active]
435590010875	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
435590010876	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
435590010877	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
435590010878	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
435590010879	Glutamine amidotransferase class-I; Region: GATase; pfam00117
435590010880	glutamine binding [chemical binding]; other site
435590010881	catalytic triad [active]
435590010882	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
435590010883	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
435590010884	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
435590010885	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
435590010886	active site
435590010887	ribulose/triose binding site [chemical binding]; other site
435590010888	phosphate binding site [ion binding]; other site
435590010889	substrate (anthranilate) binding pocket [chemical binding]; other site
435590010890	product (indole) binding pocket [chemical binding]; other site
435590010891	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
435590010892	active site
435590010893	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
435590010894	substrate binding site [chemical binding]; other site
435590010895	active site
435590010896	catalytic residues [active]
435590010897	heterodimer interface [polypeptide binding]; other site
435590010898	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
435590010899	active site
435590010900	homodimer interface [polypeptide binding]; other site
435590010901	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590010902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010903	active site
435590010904	phosphorylation site [posttranslational modification]
435590010905	intermolecular recognition site; other site
435590010906	dimerization interface [polypeptide binding]; other site
435590010907	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590010908	DNA binding site [nucleotide binding]
435590010909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010910	dimer interface [polypeptide binding]; other site
435590010911	phosphorylation site [posttranslational modification]
435590010912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010913	ATP binding site [chemical binding]; other site
435590010914	Mg2+ binding site [ion binding]; other site
435590010915	G-X-G motif; other site
435590010916	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
435590010917	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
435590010918	gliding motility-associated protein GldE; Region: GldE; TIGR03520
435590010919	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590010920	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590010921	Transporter associated domain; Region: CorC_HlyC; smart01091
435590010922	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
435590010923	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
435590010924	dimer interface [polypeptide binding]; other site
435590010925	ssDNA binding site [nucleotide binding]; other site
435590010926	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590010927	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
435590010928	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
435590010929	minor groove reading motif; other site
435590010930	helix-hairpin-helix signature motif; other site
435590010931	substrate binding pocket [chemical binding]; other site
435590010932	active site
435590010933	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
435590010934	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
435590010935	DNA binding and oxoG recognition site [nucleotide binding]
435590010936	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590010937	IHF - DNA interface [nucleotide binding]; other site
435590010938	IHF dimer interface [polypeptide binding]; other site
435590010939	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
435590010940	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
435590010941	homodimer interface [polypeptide binding]; other site
435590010942	oligonucleotide binding site [chemical binding]; other site
435590010943	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
435590010944	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
435590010945	active site
435590010946	metal binding site [ion binding]; metal-binding site
435590010947	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590010948	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
435590010949	catalytic residues [active]
435590010950	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
435590010951	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
435590010952	dimer interface [polypeptide binding]; other site
435590010953	putative anticodon binding site; other site
435590010954	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
435590010955	motif 1; other site
435590010956	active site
435590010957	motif 2; other site
435590010958	motif 3; other site
435590010959	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
435590010960	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
435590010961	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
435590010962	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
435590010963	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
435590010964	active site
435590010965	dimer interface [polypeptide binding]; other site
435590010966	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
435590010967	dimer interface [polypeptide binding]; other site
435590010968	active site
435590010969	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
435590010970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590010971	motif II; other site
435590010972	Abhydrolase family; Region: Abhydrolase_7; pfam12715
435590010973	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590010974	Secretin and TonB N terminus short domain; Region: STN; pfam07660
435590010975	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590010976	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590010977	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590010978	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
435590010979	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590010980	FecR protein; Region: FecR; pfam04773
435590010981	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590010982	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590010983	DNA binding residues [nucleotide binding]
435590010984	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
435590010985	Transcriptional regulators [Transcription]; Region: MarR; COG1846
435590010986	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
435590010987	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
435590010988	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
435590010989	Class I aldolases; Region: Aldolase_Class_I; cl17187
435590010990	catalytic residue [active]
435590010991	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
435590010992	putative active cleft [active]
435590010993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590010994	putative substrate translocation pore; other site
435590010995	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590010996	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
435590010997	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
435590010998	active site
435590010999	trimer interface [polypeptide binding]; other site
435590011000	allosteric site; other site
435590011001	active site lid [active]
435590011002	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590011003	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
435590011004	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
435590011005	active site
435590011006	trimer interface [polypeptide binding]; other site
435590011007	allosteric site; other site
435590011008	active site lid [active]
435590011009	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590011010	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
435590011011	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
435590011012	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590011013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590011014	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590011015	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
435590011016	HlyD family secretion protein; Region: HlyD_3; pfam13437
435590011017	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590011018	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590011019	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
435590011020	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590011021	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590011022	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590011023	DNA binding residues [nucleotide binding]
435590011024	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
435590011025	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
435590011026	Walker A/P-loop; other site
435590011027	ATP binding site [chemical binding]; other site
435590011028	Q-loop/lid; other site
435590011029	ABC transporter signature motif; other site
435590011030	Walker B; other site
435590011031	D-loop; other site
435590011032	H-loop/switch region; other site
435590011033	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
435590011034	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
435590011035	active site
435590011036	dimer interface [polypeptide binding]; other site
435590011037	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590011038	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590011039	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590011040	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
435590011041	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590011042	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
435590011043	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590011044	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590011045	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590011046	active site
435590011047	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590011048	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
435590011049	Galactose oxidase, central domain; Region: Kelch_3; cl02701
435590011050	Kelch motif; Region: Kelch_1; pfam01344
435590011051	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590011052	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590011053	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590011054	active site
435590011055	Fn3 associated; Region: Fn3_assoc; pfam13287
435590011056	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
435590011057	sugar binding site [chemical binding]; other site
435590011058	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
435590011059	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
435590011060	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590011061	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
435590011062	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590011063	active site
435590011064	catalytic triad [active]
435590011065	oxyanion hole [active]
435590011066	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590011067	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
435590011068	active site
435590011069	catalytic triad [active]
435590011070	oxyanion hole [active]
435590011071	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590011072	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
435590011073	active site
435590011074	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
435590011075	catalytic site [active]
435590011076	BNR repeat-like domain; Region: BNR_2; pfam13088
435590011077	Asp-box motif; other site
435590011078	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590011079	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590011080	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590011081	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
435590011082	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590011083	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
435590011084	dimer interface [polypeptide binding]; other site
435590011085	active site
435590011086	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
435590011087	ligand binding site [chemical binding]; other site
435590011088	active site
435590011089	UGI interface [polypeptide binding]; other site
435590011090	catalytic site [active]
435590011091	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
435590011092	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590011093	Zn2+ binding site [ion binding]; other site
435590011094	Mg2+ binding site [ion binding]; other site
435590011095	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
435590011096	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590011097	Catalytic site [active]
435590011098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
435590011099	Walker A/P-loop; other site
435590011100	ATP binding site [chemical binding]; other site
435590011101	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
435590011102	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590011103	Walker A/P-loop; other site
435590011104	ATP binding site [chemical binding]; other site
435590011105	Q-loop/lid; other site
435590011106	ABC transporter signature motif; other site
435590011107	Walker B; other site
435590011108	D-loop; other site
435590011109	H-loop/switch region; other site
435590011110	N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120
435590011111	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590011112	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590011113	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590011114	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
435590011115	Int/Topo IB signature motif; other site
435590011116	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590011117	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590011118	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590011119	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590011120	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590011121	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590011122	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590011123	Methyltransferase domain; Region: Methyltransf_26; pfam13659
435590011124	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
435590011125	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
435590011126	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590011127	ATP binding site [chemical binding]; other site
435590011128	putative Mg++ binding site [ion binding]; other site
435590011129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590011130	non-specific DNA binding site [nucleotide binding]; other site
435590011131	salt bridge; other site
435590011132	sequence-specific DNA binding site [nucleotide binding]; other site
435590011133	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
435590011134	GIY-YIG motif/motif A; other site
435590011135	putative active site [active]
435590011136	putative metal binding site [ion binding]; other site
435590011137	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
435590011138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
435590011139	Uncharacterized conserved protein [Function unknown]; Region: COG1479
435590011140	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590011141	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590011142	Protein of unknown function DUF262; Region: DUF262; pfam03235
435590011143	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
435590011144	Putative esterase; Region: Esterase; pfam00756
435590011145	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590011146	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590011147	active site
435590011148	substrate binding site [chemical binding]; other site
435590011149	trimer interface [polypeptide binding]; other site
435590011150	CoA binding site [chemical binding]; other site
435590011151	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
435590011152	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
435590011153	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
435590011154	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590011155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590011156	homodimer interface [polypeptide binding]; other site
435590011157	catalytic residue [active]
435590011158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
435590011159	dimerization interface [polypeptide binding]; other site
435590011160	putative DNA binding site [nucleotide binding]; other site
435590011161	Transcriptional regulators [Transcription]; Region: MarR; COG1846
435590011162	putative Zn2+ binding site [ion binding]; other site
435590011163	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
435590011164	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
435590011165	Family description; Region: DsbD_2; pfam13386
435590011166	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
435590011167	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
435590011168	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
435590011169	P loop; other site
435590011170	Nucleotide binding site [chemical binding]; other site
435590011171	DTAP/Switch II; other site
435590011172	Switch I; other site
435590011173	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
435590011174	P loop; other site
435590011175	Nucleotide binding site [chemical binding]; other site
435590011176	DTAP/Switch II; other site
435590011177	Switch I; other site
435590011178	Low molecular weight phosphatase family; Region: LMWPc; cd00115
435590011179	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
435590011180	active site
435590011181	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
435590011182	arsenical-resistance protein; Region: acr3; TIGR00832
435590011183	Cna protein B-type domain; Region: Cna_B_2; pfam13715
435590011184	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590011185	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
435590011186	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
435590011187	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
435590011188	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
435590011189	active site
435590011190	metal binding site [ion binding]; metal-binding site
435590011191	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
435590011192	mce related protein; Region: MCE; pfam02470