-- dump date 20140619_001241 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264462000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 264462000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462000003 Walker A motif; other site 264462000004 ATP binding site [chemical binding]; other site 264462000005 Walker B motif; other site 264462000006 arginine finger; other site 264462000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264462000008 DnaA box-binding interface [nucleotide binding]; other site 264462000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 264462000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264462000011 putative DNA binding surface [nucleotide binding]; other site 264462000012 dimer interface [polypeptide binding]; other site 264462000013 beta-clamp/clamp loader binding surface; other site 264462000014 beta-clamp/translesion DNA polymerase binding surface; other site 264462000015 recombination protein F; Reviewed; Region: recF; PRK00064 264462000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462000017 Walker A/P-loop; other site 264462000018 ATP binding site [chemical binding]; other site 264462000019 Q-loop/lid; other site 264462000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462000021 ABC transporter signature motif; other site 264462000022 Walker B; other site 264462000023 D-loop; other site 264462000024 H-loop/switch region; other site 264462000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 264462000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462000027 ATP binding site [chemical binding]; other site 264462000028 Mg2+ binding site [ion binding]; other site 264462000029 G-X-G motif; other site 264462000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264462000031 anchoring element; other site 264462000032 dimer interface [polypeptide binding]; other site 264462000033 ATP binding site [chemical binding]; other site 264462000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264462000035 active site 264462000036 putative metal-binding site [ion binding]; other site 264462000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264462000038 DNA gyrase subunit A; Validated; Region: PRK05560 264462000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264462000040 CAP-like domain; other site 264462000041 active site 264462000042 primary dimer interface [polypeptide binding]; other site 264462000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264462000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264462000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264462000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264462000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264462000048 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 264462000049 ATP synthase subunit C; Region: ATP-synt_C; cl00466 264462000050 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264462000051 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 264462000052 DNA binding residues [nucleotide binding] 264462000053 drug binding residues [chemical binding]; other site 264462000054 dimer interface [polypeptide binding]; other site 264462000055 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 264462000056 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 264462000057 active site 264462000058 substrate binding site [chemical binding]; other site 264462000059 metal binding site [ion binding]; metal-binding site 264462000060 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264462000061 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 264462000062 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 264462000063 SurA N-terminal domain; Region: SurA_N; pfam09312 264462000064 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264462000065 SurA N-terminal domain; Region: SurA_N_3; cl07813 264462000066 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 264462000067 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 264462000068 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264462000069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 264462000070 putative acyl-acceptor binding pocket; other site 264462000071 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264462000072 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264462000073 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264462000074 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264462000075 Ligand binding site [chemical binding]; other site 264462000076 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264462000077 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 264462000078 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 264462000079 putative Iron-sulfur protein interface [polypeptide binding]; other site 264462000080 proximal heme binding site [chemical binding]; other site 264462000081 distal heme binding site [chemical binding]; other site 264462000082 putative dimer interface [polypeptide binding]; other site 264462000083 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 264462000084 L-aspartate oxidase; Provisional; Region: PRK06175 264462000085 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264462000086 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 264462000087 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264462000088 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462000089 catalytic triad [active] 264462000090 putative active site [active] 264462000091 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 264462000092 heterodimerization interface [polypeptide binding]; other site 264462000093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462000096 phosphopeptide binding site; other site 264462000097 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 264462000098 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 264462000099 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264462000100 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264462000101 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264462000102 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462000103 active site 264462000104 substrate binding sites [chemical binding]; other site 264462000105 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264462000106 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 264462000107 NADP binding site [chemical binding]; other site 264462000108 active site 264462000109 steroid binding site; other site 264462000110 replicative DNA helicase; Region: DnaB; TIGR00665 264462000111 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264462000112 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264462000113 Walker A motif; other site 264462000114 ATP binding site [chemical binding]; other site 264462000115 Walker B motif; other site 264462000116 DNA binding loops [nucleotide binding] 264462000117 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264462000118 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 264462000119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462000120 FeS/SAM binding site; other site 264462000121 Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport; Region: RabGEF; cl00180 264462000122 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264462000123 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 264462000124 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264462000125 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264462000126 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264462000127 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264462000128 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264462000129 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 264462000130 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264462000131 dimer interface [polypeptide binding]; other site 264462000132 active site 264462000133 catalytic residue [active] 264462000134 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264462000135 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264462000136 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264462000137 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 264462000138 active site 264462000139 intersubunit interactions; other site 264462000140 catalytic residue [active] 264462000141 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 264462000142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462000143 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462000144 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264462000145 putative active site [active] 264462000146 putative metal binding site [ion binding]; other site 264462000147 Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; Region: H2A; cl00074 264462000148 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 264462000149 active site 264462000150 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264462000151 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264462000152 nucleotide binding pocket [chemical binding]; other site 264462000153 K-X-D-G motif; other site 264462000154 catalytic site [active] 264462000155 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264462000156 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264462000157 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264462000158 Dimer interface [polypeptide binding]; other site 264462000159 BRCT sequence motif; other site 264462000160 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 264462000161 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264462000162 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 264462000163 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264462000164 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264462000165 GatB domain; Region: GatB_Yqey; smart00845 264462000166 exopolyphosphatase; Region: exo_poly_only; TIGR03706 264462000167 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 264462000168 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 264462000169 PilZ domain; Region: PilZ; pfam07238 264462000170 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264462000171 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 264462000172 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264462000173 RNA binding site [nucleotide binding]; other site 264462000174 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264462000175 multimer interface [polypeptide binding]; other site 264462000176 Walker A motif; other site 264462000177 ATP binding site [chemical binding]; other site 264462000178 Walker B motif; other site 264462000179 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 264462000180 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264462000181 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264462000182 RF-1 domain; Region: RF-1; pfam00472 264462000183 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 264462000184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462000185 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264462000186 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264462000187 hinge; other site 264462000188 active site 264462000189 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 264462000190 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 264462000191 NodB motif; other site 264462000192 putative active site [active] 264462000193 putative catalytic site [active] 264462000194 putative Zn binding site [ion binding]; other site 264462000195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000196 TPR motif; other site 264462000197 binding surface 264462000198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000199 binding surface 264462000200 TPR motif; other site 264462000201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000202 TPR motif; other site 264462000203 binding surface 264462000204 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462000205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000206 binding surface 264462000207 TPR motif; other site 264462000208 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462000209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000210 binding surface 264462000211 TPR motif; other site 264462000212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462000213 seryl-tRNA synthetase; Provisional; Region: PRK05431 264462000214 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264462000215 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264462000216 dimer interface [polypeptide binding]; other site 264462000217 active site 264462000218 motif 1; other site 264462000219 motif 2; other site 264462000220 motif 3; other site 264462000221 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264462000222 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264462000223 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264462000224 cyclase homology domain; Region: CHD; cd07302 264462000225 metal binding site [ion binding]; metal-binding site 264462000226 nucleotidyl binding site; other site 264462000227 dimer interface [polypeptide binding]; other site 264462000228 Domain of unknown function (DUF333); Region: DUF333; pfam03891 264462000229 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 264462000230 active site 264462000231 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264462000232 nucleoside/Zn binding site; other site 264462000233 dimer interface [polypeptide binding]; other site 264462000234 catalytic motif [active] 264462000235 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 264462000236 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462000237 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 264462000238 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264462000239 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264462000240 oligomerisation interface [polypeptide binding]; other site 264462000241 mobile loop; other site 264462000242 roof hairpin; other site 264462000243 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264462000244 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264462000245 ring oligomerisation interface [polypeptide binding]; other site 264462000246 ATP/Mg binding site [chemical binding]; other site 264462000247 stacking interactions; other site 264462000248 hinge regions; other site 264462000249 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462000250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000251 Response regulator receiver domain; Region: Response_reg; pfam00072 264462000252 active site 264462000253 phosphorylation site [posttranslational modification] 264462000254 intermolecular recognition site; other site 264462000255 dimerization interface [polypeptide binding]; other site 264462000256 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 264462000257 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462000258 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264462000259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264462000260 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264462000261 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264462000262 ATP binding site [chemical binding]; other site 264462000263 Walker A motif; other site 264462000264 hexamer interface [polypeptide binding]; other site 264462000265 Walker B motif; other site 264462000266 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 264462000267 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264462000268 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 264462000269 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264462000270 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462000271 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462000272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462000273 dimer interface [polypeptide binding]; other site 264462000274 putative CheW interface [polypeptide binding]; other site 264462000275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462000276 active site 264462000277 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462000278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000279 binding surface 264462000280 TPR motif; other site 264462000281 TPR repeat; Region: TPR_11; pfam13414 264462000282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000283 binding surface 264462000284 TPR motif; other site 264462000285 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462000286 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 264462000287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264462000288 binding surface 264462000289 TPR motif; other site 264462000290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000291 binding surface 264462000292 TPR repeat; Region: TPR_11; pfam13414 264462000293 TPR motif; other site 264462000294 transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707 264462000295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264462000296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462000297 catalytic residue [active] 264462000298 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 264462000299 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 264462000300 metal binding site [ion binding]; metal-binding site 264462000301 dimer interface [polypeptide binding]; other site 264462000302 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 264462000303 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 264462000304 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 264462000305 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 264462000306 NAD(P) binding site [chemical binding]; other site 264462000307 catalytic residues [active] 264462000308 YceG-like family; Region: YceG; pfam02618 264462000309 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264462000310 dimerization interface [polypeptide binding]; other site 264462000311 aspartate kinase III; Validated; Region: PRK09084 264462000312 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 264462000313 nucleotide binding site [chemical binding]; other site 264462000314 putative catalytic residues [active] 264462000315 aspartate binding site [chemical binding]; other site 264462000316 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 264462000317 lysine allosteric regulatory site; other site 264462000318 dimer interface [polypeptide binding]; other site 264462000319 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 264462000320 dimer interface [polypeptide binding]; other site 264462000321 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 264462000322 FMN binding site [chemical binding]; other site 264462000323 dimer interface [polypeptide binding]; other site 264462000324 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264462000325 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264462000326 FMN binding site [chemical binding]; other site 264462000327 active site 264462000328 catalytic residues [active] 264462000329 substrate binding site [chemical binding]; other site 264462000330 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264462000331 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264462000332 G1 box; other site 264462000333 putative GEF interaction site [polypeptide binding]; other site 264462000334 GTP/Mg2+ binding site [chemical binding]; other site 264462000335 Switch I region; other site 264462000336 G2 box; other site 264462000337 G3 box; other site 264462000338 Switch II region; other site 264462000339 G4 box; other site 264462000340 G5 box; other site 264462000341 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264462000342 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264462000343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264462000344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462000345 Walker A/P-loop; other site 264462000346 ATP binding site [chemical binding]; other site 264462000347 Q-loop/lid; other site 264462000348 ABC transporter signature motif; other site 264462000349 Walker B; other site 264462000350 D-loop; other site 264462000351 H-loop/switch region; other site 264462000352 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264462000353 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264462000354 Protein of unknown function (DUF523); Region: DUF523; pfam04463 264462000355 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 264462000356 Transglycosylase; Region: Transgly; pfam00912 264462000357 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 264462000358 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 264462000359 putative NADP binding site [chemical binding]; other site 264462000360 putative substrate binding site [chemical binding]; other site 264462000361 active site 264462000362 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264462000363 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 264462000364 active site 264462000365 flagellar motor protein MotA; Validated; Region: PRK08124 264462000366 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264462000367 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 264462000368 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264462000369 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462000370 ligand binding site [chemical binding]; other site 264462000371 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264462000372 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 264462000373 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 264462000374 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 264462000375 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 264462000376 Substrate binding site; other site 264462000377 metal-binding site 264462000378 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264462000379 putative CoA binding site [chemical binding]; other site 264462000380 Phosphotransferase enzyme family; Region: APH; pfam01636 264462000381 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 264462000382 Nif-specific regulatory protein; Region: nifA; TIGR01817 264462000383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462000384 Walker A motif; other site 264462000385 ATP binding site [chemical binding]; other site 264462000386 Walker B motif; other site 264462000387 arginine finger; other site 264462000388 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462000389 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264462000390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462000391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462000392 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 264462000393 Walker A/P-loop; other site 264462000394 ATP binding site [chemical binding]; other site 264462000395 Q-loop/lid; other site 264462000396 ABC transporter signature motif; other site 264462000397 Walker B; other site 264462000398 D-loop; other site 264462000399 H-loop/switch region; other site 264462000400 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264462000401 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264462000402 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264462000403 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264462000404 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 264462000405 Transglycosylase; Region: Transgly; pfam00912 264462000406 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264462000407 RNA binding site [nucleotide binding]; other site 264462000408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264462000409 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 264462000410 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264462000411 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264462000412 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 264462000413 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 264462000414 Protein of unknown function, DUF481; Region: DUF481; pfam04338 264462000415 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 264462000416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462000417 Walker A/P-loop; other site 264462000418 ATP binding site [chemical binding]; other site 264462000419 Q-loop/lid; other site 264462000420 ABC transporter signature motif; other site 264462000421 Walker B; other site 264462000422 D-loop; other site 264462000423 H-loop/switch region; other site 264462000424 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 264462000425 FtsX-like permease family; Region: FtsX; pfam02687 264462000426 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 264462000427 Peptidase family M23; Region: Peptidase_M23; pfam01551 264462000428 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264462000429 C-terminal peptidase (prc); Region: prc; TIGR00225 264462000430 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264462000431 protein binding site [polypeptide binding]; other site 264462000432 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264462000433 Catalytic dyad [active] 264462000434 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264462000435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462000436 catalytic residues [active] 264462000437 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 264462000438 active site 264462000439 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264462000440 metal binding triad; other site 264462000441 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264462000442 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264462000443 metal binding triad; other site 264462000444 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264462000445 TolB amino-terminal domain; Region: TolB_N; pfam04052 264462000446 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 264462000447 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462000448 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462000449 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462000450 TonB C terminal; Region: TonB_2; pfam13103 264462000451 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264462000452 TolR protein; Region: tolR; TIGR02801 264462000453 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264462000454 Transcriptional regulator; Region: Rrf2; pfam02082 264462000455 Rrf2 family protein; Region: rrf2_super; TIGR00738 264462000456 Transcriptional regulator; Region: Rrf2; cl17282 264462000457 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 264462000458 putative ABC transporter; Region: ycf24; CHL00085 264462000459 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 264462000460 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 264462000461 Walker A/P-loop; other site 264462000462 ATP binding site [chemical binding]; other site 264462000463 Q-loop/lid; other site 264462000464 ABC transporter signature motif; other site 264462000465 Walker B; other site 264462000466 D-loop; other site 264462000467 H-loop/switch region; other site 264462000468 FeS assembly protein SufD; Region: sufD; TIGR01981 264462000469 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 264462000470 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264462000471 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264462000472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462000473 catalytic residue [active] 264462000474 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 264462000475 NifU-like domain; Region: NifU; cl00484 264462000476 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 264462000477 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264462000478 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264462000479 generic binding surface II; other site 264462000480 generic binding surface I; other site 264462000481 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 264462000482 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264462000483 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264462000484 substrate binding pocket [chemical binding]; other site 264462000485 chain length determination region; other site 264462000486 substrate-Mg2+ binding site; other site 264462000487 catalytic residues [active] 264462000488 aspartate-rich region 1; other site 264462000489 active site lid residues [active] 264462000490 aspartate-rich region 2; other site 264462000491 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 264462000492 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462000493 RNA binding surface [nucleotide binding]; other site 264462000494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462000495 S-adenosylmethionine binding site [chemical binding]; other site 264462000496 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264462000497 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264462000498 active site 264462000499 nucleophile elbow; other site 264462000500 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 264462000501 proline aminopeptidase P II; Provisional; Region: PRK10879 264462000502 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264462000503 active site 264462000504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264462000505 PAS domain; Region: PAS_9; pfam13426 264462000506 putative active site [active] 264462000507 heme pocket [chemical binding]; other site 264462000508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462000509 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264462000510 putative CheW interface [polypeptide binding]; other site 264462000511 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264462000512 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 264462000513 Poxvirus I3 ssDNA-binding protein; Region: Pox_I3; cl17649 264462000514 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 264462000515 rod shape-determining protein MreB; Provisional; Region: PRK13927 264462000516 MreB and similar proteins; Region: MreB_like; cd10225 264462000517 nucleotide binding site [chemical binding]; other site 264462000518 Mg binding site [ion binding]; other site 264462000519 putative protofilament interaction site [polypeptide binding]; other site 264462000520 RodZ interaction site [polypeptide binding]; other site 264462000521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 264462000522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462000523 dimerization interface [polypeptide binding]; other site 264462000524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462000525 dimer interface [polypeptide binding]; other site 264462000526 phosphorylation site [posttranslational modification] 264462000527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462000528 ATP binding site [chemical binding]; other site 264462000529 Mg2+ binding site [ion binding]; other site 264462000530 G-X-G motif; other site 264462000531 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264462000532 MPN+ (JAMM) motif; other site 264462000533 Zinc-binding site [ion binding]; other site 264462000534 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 264462000535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 264462000536 GYD domain; Region: GYD; cl01743 264462000537 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 264462000538 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 264462000539 TPR repeat; Region: TPR_11; pfam13414 264462000540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000541 binding surface 264462000542 TPR motif; other site 264462000543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000544 binding surface 264462000545 TPR motif; other site 264462000546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462000547 TPR motif; other site 264462000548 binding surface 264462000549 TPR repeat; Region: TPR_11; pfam13414 264462000550 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 264462000551 TPR repeat; Region: TPR_11; pfam13414 264462000552 PrkA AAA domain; Region: AAA_PrkA; smart00763 264462000553 AAA ATPase domain; Region: AAA_16; pfam13191 264462000554 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 264462000555 hypothetical protein; Provisional; Region: PRK05325 264462000556 SpoVR like protein; Region: SpoVR; pfam04293 264462000557 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 264462000558 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 264462000559 putative rRNA binding site [nucleotide binding]; other site 264462000560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462000561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000562 active site 264462000563 phosphorylation site [posttranslational modification] 264462000564 intermolecular recognition site; other site 264462000565 dimerization interface [polypeptide binding]; other site 264462000566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462000567 DNA binding site [nucleotide binding] 264462000568 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 264462000569 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264462000570 catalytic triad [active] 264462000571 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462000572 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264462000573 ATP binding site [chemical binding]; other site 264462000574 Mg++ binding site [ion binding]; other site 264462000575 motif III; other site 264462000576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462000577 nucleotide binding region [chemical binding]; other site 264462000578 ATP-binding site [chemical binding]; other site 264462000579 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264462000580 nucleoside/Zn binding site; other site 264462000581 dimer interface [polypeptide binding]; other site 264462000582 catalytic motif [active] 264462000583 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264462000584 nudix motif; other site 264462000585 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 264462000586 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 264462000587 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 264462000588 Yqey-like protein; Region: YqeY; pfam09424 264462000589 DNA primase; Validated; Region: dnaG; PRK05667 264462000590 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264462000591 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264462000592 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264462000593 active site 264462000594 metal binding site [ion binding]; metal-binding site 264462000595 interdomain interaction site; other site 264462000596 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264462000597 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264462000598 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 264462000599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462000600 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264462000601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462000602 DNA binding residues [nucleotide binding] 264462000603 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 264462000604 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 264462000605 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 264462000606 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264462000607 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 264462000608 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264462000609 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 264462000610 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264462000611 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 264462000612 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264462000613 DNA binding site [nucleotide binding] 264462000614 active site 264462000615 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 264462000616 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 264462000617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264462000618 AlkA N-terminal domain; Region: AlkA_N; pfam06029 264462000619 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 264462000620 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264462000621 minor groove reading motif; other site 264462000622 helix-hairpin-helix signature motif; other site 264462000623 substrate binding pocket [chemical binding]; other site 264462000624 active site 264462000625 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264462000626 active site 264462000627 catalytic site [active] 264462000628 substrate binding site [chemical binding]; other site 264462000629 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264462000630 GIY-YIG motif/motif A; other site 264462000631 active site 264462000632 catalytic site [active] 264462000633 putative DNA binding site [nucleotide binding]; other site 264462000634 metal binding site [ion binding]; metal-binding site 264462000635 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264462000636 DEAD_2; Region: DEAD_2; pfam06733 264462000637 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264462000638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462000639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264462000640 substrate binding pocket [chemical binding]; other site 264462000641 membrane-bound complex binding site; other site 264462000642 hinge residues; other site 264462000643 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264462000644 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 264462000645 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264462000646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462000647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462000648 dimer interface [polypeptide binding]; other site 264462000649 putative CheW interface [polypeptide binding]; other site 264462000650 EamA-like transporter family; Region: EamA; pfam00892 264462000651 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264462000652 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 264462000653 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264462000654 lipoyl attachment site [posttranslational modification]; other site 264462000655 glutamine synthetase, type I; Region: GlnA; TIGR00653 264462000656 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264462000657 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264462000658 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 264462000659 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 264462000660 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264462000661 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264462000662 putative active site pocket [active] 264462000663 dimerization interface [polypeptide binding]; other site 264462000664 putative catalytic residue [active] 264462000665 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 264462000666 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 264462000667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264462000668 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 264462000669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 264462000670 nucleotide binding region [chemical binding]; other site 264462000671 ATP-binding site [chemical binding]; other site 264462000672 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 264462000673 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264462000674 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 264462000675 active site 264462000676 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264462000677 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264462000678 acyl-activating enzyme (AAE) consensus motif; other site 264462000679 putative AMP binding site [chemical binding]; other site 264462000680 putative active site [active] 264462000681 putative CoA binding site [chemical binding]; other site 264462000682 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 264462000683 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264462000684 dimer interface [polypeptide binding]; other site 264462000685 active site 264462000686 CoA binding pocket [chemical binding]; other site 264462000687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264462000688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462000689 NAD(P) binding site [chemical binding]; other site 264462000690 active site 264462000691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462000692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462000693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462000694 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 264462000695 catalytic site [active] 264462000696 Cytochrome c; Region: Cytochrom_C; pfam00034 264462000697 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 264462000698 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264462000699 Cu(I) binding site [ion binding]; other site 264462000700 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 264462000701 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264462000702 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264462000703 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264462000704 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 264462000705 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 264462000706 Subunit I/III interface [polypeptide binding]; other site 264462000707 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 264462000708 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 264462000709 UbiA prenyltransferase family; Region: UbiA; pfam01040 264462000710 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264462000711 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264462000712 C-terminal domain interface [polypeptide binding]; other site 264462000713 GSH binding site (G-site) [chemical binding]; other site 264462000714 putative dimer interface [polypeptide binding]; other site 264462000715 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264462000716 dimer interface [polypeptide binding]; other site 264462000717 N-terminal domain interface [polypeptide binding]; other site 264462000718 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264462000719 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 264462000720 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264462000721 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264462000722 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264462000723 E-class dimer interface [polypeptide binding]; other site 264462000724 P-class dimer interface [polypeptide binding]; other site 264462000725 active site 264462000726 Cu2+ binding site [ion binding]; other site 264462000727 Zn2+ binding site [ion binding]; other site 264462000728 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 264462000729 MG2 domain; Region: A2M_N; pfam01835 264462000730 Alpha-2-macroglobulin family; Region: A2M; pfam00207 264462000731 Transglycosylase; Region: Transgly; pfam00912 264462000732 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264462000733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264462000734 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 264462000735 OsmC-like protein; Region: OsmC; pfam02566 264462000736 Response regulator receiver domain; Region: Response_reg; pfam00072 264462000737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000738 active site 264462000739 phosphorylation site [posttranslational modification] 264462000740 intermolecular recognition site; other site 264462000741 dimerization interface [polypeptide binding]; other site 264462000742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462000743 PAS fold; Region: PAS_3; pfam08447 264462000744 putative active site [active] 264462000745 heme pocket [chemical binding]; other site 264462000746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462000747 dimer interface [polypeptide binding]; other site 264462000748 phosphorylation site [posttranslational modification] 264462000749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462000750 ATP binding site [chemical binding]; other site 264462000751 Mg2+ binding site [ion binding]; other site 264462000752 G-X-G motif; other site 264462000753 Response regulator receiver domain; Region: Response_reg; pfam00072 264462000754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000755 active site 264462000756 phosphorylation site [posttranslational modification] 264462000757 intermolecular recognition site; other site 264462000758 dimerization interface [polypeptide binding]; other site 264462000759 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264462000760 putative binding surface; other site 264462000761 active site 264462000762 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 264462000763 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 264462000764 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264462000765 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264462000766 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264462000767 NAD(P) binding site [chemical binding]; other site 264462000768 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 264462000769 active site 264462000770 Zn binding site [ion binding]; other site 264462000771 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 264462000772 Phosphotransferase enzyme family; Region: APH; pfam01636 264462000773 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 264462000774 Pirin; Region: Pirin; pfam02678 264462000775 Pirin-related protein [General function prediction only]; Region: COG1741 264462000776 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264462000777 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 264462000778 benzoate transporter; Region: benE; TIGR00843 264462000779 Benzoate membrane transport protein; Region: BenE; pfam03594 264462000780 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264462000781 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 264462000782 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 264462000783 dimer interface [polypeptide binding]; other site 264462000784 catalytic triad [active] 264462000785 peroxidatic and resolving cysteines [active] 264462000786 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462000787 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264462000788 ATP binding site [chemical binding]; other site 264462000789 Mg++ binding site [ion binding]; other site 264462000790 motif III; other site 264462000791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462000792 nucleotide binding region [chemical binding]; other site 264462000793 ATP-binding site [chemical binding]; other site 264462000794 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 264462000795 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 264462000796 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264462000797 rRNA binding site [nucleotide binding]; other site 264462000798 predicted 30S ribosome binding site; other site 264462000799 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264462000800 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264462000801 RibD C-terminal domain; Region: RibD_C; cl17279 264462000802 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264462000803 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 264462000804 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462000805 ATP binding site [chemical binding]; other site 264462000806 Mg++ binding site [ion binding]; other site 264462000807 motif III; other site 264462000808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462000809 nucleotide binding region [chemical binding]; other site 264462000810 ATP-binding site [chemical binding]; other site 264462000811 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264462000812 ArsC family; Region: ArsC; pfam03960 264462000813 catalytic residues [active] 264462000814 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264462000815 catalytic residues [active] 264462000816 dimer interface [polypeptide binding]; other site 264462000817 short chain dehydrogenase; Provisional; Region: PRK06924 264462000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462000819 NAD(P) binding site [chemical binding]; other site 264462000820 active site 264462000821 Family description; Region: VCBS; pfam13517 264462000822 Family description; Region: VCBS; pfam13517 264462000823 Family description; Region: VCBS; pfam13517 264462000824 Family description; Region: VCBS; pfam13517 264462000825 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 264462000826 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264462000827 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 264462000828 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 264462000829 active site 264462000830 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264462000831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462000832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462000833 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264462000834 muropeptide transporter; Validated; Region: ampG; cl17669 264462000835 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462000836 active site 264462000837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462000838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264462000839 Coenzyme A binding pocket [chemical binding]; other site 264462000840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264462000841 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 264462000842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 264462000843 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 264462000844 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 264462000845 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 264462000846 active site 264462000847 catalytic triad [active] 264462000848 oxyanion hole [active] 264462000849 switch loop; other site 264462000850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462000851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462000852 Walker A/P-loop; other site 264462000853 ATP binding site [chemical binding]; other site 264462000854 Q-loop/lid; other site 264462000855 ABC transporter signature motif; other site 264462000856 Walker B; other site 264462000857 D-loop; other site 264462000858 H-loop/switch region; other site 264462000859 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264462000860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462000861 FtsX-like permease family; Region: FtsX; pfam02687 264462000862 FtsX-like permease family; Region: FtsX; pfam02687 264462000863 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 264462000864 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 264462000865 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264462000866 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264462000867 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264462000868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 264462000869 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264462000870 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264462000871 putative acyl-acceptor binding pocket; other site 264462000872 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264462000873 active site 264462000874 DNA polymerase IV; Validated; Region: PRK02406 264462000875 DNA binding site [nucleotide binding] 264462000876 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 264462000877 ArsC family; Region: ArsC; pfam03960 264462000878 putative ArsC-like catalytic residues; other site 264462000879 putative TRX-like catalytic residues [active] 264462000880 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 264462000881 putative active site [active] 264462000882 Mn binding site [ion binding]; other site 264462000883 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 264462000884 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264462000885 peptide binding site [polypeptide binding]; other site 264462000886 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264462000887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462000888 dimer interface [polypeptide binding]; other site 264462000889 conserved gate region; other site 264462000890 putative PBP binding loops; other site 264462000891 ABC-ATPase subunit interface; other site 264462000892 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264462000893 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264462000894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462000895 dimer interface [polypeptide binding]; other site 264462000896 conserved gate region; other site 264462000897 putative PBP binding loops; other site 264462000898 ABC-ATPase subunit interface; other site 264462000899 arginine decarboxylase; Provisional; Region: PRK05354 264462000900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 264462000901 dimer interface [polypeptide binding]; other site 264462000902 active site 264462000903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264462000904 catalytic residues [active] 264462000905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 264462000906 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264462000907 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264462000908 HIGH motif; other site 264462000909 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264462000910 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264462000911 active site 264462000912 KMSKS motif; other site 264462000913 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264462000914 tRNA binding surface [nucleotide binding]; other site 264462000915 Response regulator receiver domain; Region: Response_reg; pfam00072 264462000916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000917 active site 264462000918 phosphorylation site [posttranslational modification] 264462000919 intermolecular recognition site; other site 264462000920 dimerization interface [polypeptide binding]; other site 264462000921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264462000922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264462000923 metal binding site [ion binding]; metal-binding site 264462000924 active site 264462000925 I-site; other site 264462000926 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264462000927 Cation efflux family; Region: Cation_efflux; pfam01545 264462000928 Putative methyltransferase; Region: Methyltransf_4; cl17290 264462000929 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264462000930 catalytic loop [active] 264462000931 iron binding site [ion binding]; other site 264462000932 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264462000933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264462000934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462000935 Response regulator receiver domain; Region: Response_reg; pfam00072 264462000936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462000937 active site 264462000938 phosphorylation site [posttranslational modification] 264462000939 intermolecular recognition site; other site 264462000940 dimerization interface [polypeptide binding]; other site 264462000941 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 264462000942 calcium binding site 1 [ion binding]; other site 264462000943 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264462000944 active site 264462000945 catalytic triad [active] 264462000946 calcium binding site 2 [ion binding]; other site 264462000947 calcium binding site 3 [ion binding]; other site 264462000948 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 264462000949 PilZ domain; Region: PilZ; pfam07238 264462000950 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264462000951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462000952 motif II; other site 264462000953 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264462000954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462000955 ligand binding site [chemical binding]; other site 264462000956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264462000957 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 264462000958 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 264462000959 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 264462000960 putative active site [active] 264462000961 putative PHP Thumb interface [polypeptide binding]; other site 264462000962 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264462000963 generic binding surface II; other site 264462000964 generic binding surface I; other site 264462000965 Y-family of DNA polymerases; Region: PolY; cl12025 264462000966 DNA binding site [nucleotide binding] 264462000967 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264462000968 Walker A motif; other site 264462000969 ATP binding site [chemical binding]; other site 264462000970 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 264462000971 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264462000972 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264462000973 DNA binding site [nucleotide binding] 264462000974 active site 264462000975 Methyltransferase domain; Region: Methyltransf_18; pfam12847 264462000976 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462000977 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264462000978 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 264462000979 dimer interface [polypeptide binding]; other site 264462000980 TPP-binding site [chemical binding]; other site 264462000981 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 264462000982 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 264462000983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462000984 putative substrate translocation pore; other site 264462000985 Pup-ligase protein; Region: Pup_ligase; cl15463 264462000986 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264462000987 Protein phosphatase 2C; Region: PP2C; pfam00481 264462000988 active site 264462000989 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264462000990 Peptidase family M23; Region: Peptidase_M23; pfam01551 264462000991 putative acyltransferase; Provisional; Region: PRK05790 264462000992 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264462000993 dimer interface [polypeptide binding]; other site 264462000994 active site 264462000995 short chain dehydrogenase; Provisional; Region: PRK12939 264462000996 classical (c) SDRs; Region: SDR_c; cd05233 264462000997 NAD(P) binding site [chemical binding]; other site 264462000998 active site 264462000999 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 264462001000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462001001 Zn2+ binding site [ion binding]; other site 264462001002 Mg2+ binding site [ion binding]; other site 264462001003 flagellin; Provisional; Region: PRK12802 264462001004 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462001005 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462001006 flagellin; Provisional; Region: PRK12802 264462001007 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462001008 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462001009 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 264462001010 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462001011 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264462001012 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462001013 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264462001014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462001015 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264462001016 ABC1 family; Region: ABC1; pfam03109 264462001017 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 264462001018 active site 264462001019 ATP binding site [chemical binding]; other site 264462001020 ribonuclease R; Region: RNase_R; TIGR02063 264462001021 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264462001022 RNB domain; Region: RNB; pfam00773 264462001023 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264462001024 RNA binding site [nucleotide binding]; other site 264462001025 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 264462001026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462001027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001028 active site 264462001029 phosphorylation site [posttranslational modification] 264462001030 intermolecular recognition site; other site 264462001031 dimerization interface [polypeptide binding]; other site 264462001032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462001033 DNA binding site [nucleotide binding] 264462001034 threonine and homoserine efflux system; Provisional; Region: PRK10532 264462001035 EamA-like transporter family; Region: EamA; pfam00892 264462001036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264462001037 Beta-lactamase; Region: Beta-lactamase; pfam00144 264462001038 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 264462001039 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264462001040 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264462001041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264462001042 TM-ABC transporter signature motif; other site 264462001043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264462001044 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264462001045 TM-ABC transporter signature motif; other site 264462001046 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264462001047 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264462001048 Walker A/P-loop; other site 264462001049 ATP binding site [chemical binding]; other site 264462001050 Q-loop/lid; other site 264462001051 ABC transporter signature motif; other site 264462001052 Walker B; other site 264462001053 D-loop; other site 264462001054 H-loop/switch region; other site 264462001055 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264462001056 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264462001057 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 264462001058 ligand binding site [chemical binding]; other site 264462001059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462001060 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 264462001061 ligand binding site [chemical binding]; other site 264462001062 flexible hinge region; other site 264462001063 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264462001064 putative switch regulator; other site 264462001065 non-specific DNA interactions [nucleotide binding]; other site 264462001066 DNA binding site [nucleotide binding] 264462001067 sequence specific DNA binding site [nucleotide binding]; other site 264462001068 putative cAMP binding site [chemical binding]; other site 264462001069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462001070 S-adenosylmethionine binding site [chemical binding]; other site 264462001071 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264462001072 PLD-like domain; Region: PLDc_2; pfam13091 264462001073 putative active site [active] 264462001074 catalytic site [active] 264462001075 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264462001076 PLD-like domain; Region: PLDc_2; pfam13091 264462001077 putative active site [active] 264462001078 catalytic site [active] 264462001079 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 264462001080 catalytic residues [active] 264462001081 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264462001082 homodimer interaction site [polypeptide binding]; other site 264462001083 cofactor binding site; other site 264462001084 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 264462001085 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 264462001086 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 264462001087 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 264462001088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462001089 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264462001090 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264462001091 HIGH motif; other site 264462001092 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264462001093 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264462001094 active site 264462001095 KMSKS motif; other site 264462001096 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264462001097 tRNA binding surface [nucleotide binding]; other site 264462001098 anticodon binding site; other site 264462001099 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264462001100 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 264462001101 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462001102 active site residue [active] 264462001103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462001104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264462001105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264462001106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462001107 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 264462001108 DivIVA protein; Region: DivIVA; pfam05103 264462001109 DivIVA domain; Region: DivI1A_domain; TIGR03544 264462001110 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 264462001111 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 264462001112 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 264462001113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 264462001114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264462001115 catalytic residue [active] 264462001116 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264462001117 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264462001118 NodB motif; other site 264462001119 active site 264462001120 catalytic site [active] 264462001121 metal binding site [ion binding]; metal-binding site 264462001122 Maf-like protein; Region: Maf; pfam02545 264462001123 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264462001124 active site 264462001125 dimer interface [polypeptide binding]; other site 264462001126 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 264462001127 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462001128 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 264462001129 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462001131 phosphopeptide binding site; other site 264462001132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462001134 phosphopeptide binding site; other site 264462001135 FHA domain; Region: FHA; pfam00498 264462001136 phosphopeptide binding site; other site 264462001137 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462001138 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001139 phosphopeptide binding site; other site 264462001140 Sulfatase; Region: Sulfatase; cl17466 264462001141 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 264462001142 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462001143 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264462001144 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 264462001145 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 264462001146 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264462001147 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264462001148 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 264462001149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264462001150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001152 substrate binding pocket [chemical binding]; other site 264462001153 membrane-bound complex binding site; other site 264462001154 hinge residues; other site 264462001155 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264462001156 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264462001157 dimerization interface 3.5A [polypeptide binding]; other site 264462001158 active site 264462001159 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264462001160 23S rRNA interface [nucleotide binding]; other site 264462001161 L3 interface [polypeptide binding]; other site 264462001162 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264462001163 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 264462001164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462001165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462001166 dimer interface [polypeptide binding]; other site 264462001167 phosphorylation site [posttranslational modification] 264462001168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462001169 ATP binding site [chemical binding]; other site 264462001170 Mg2+ binding site [ion binding]; other site 264462001171 G-X-G motif; other site 264462001172 Response regulator receiver domain; Region: Response_reg; pfam00072 264462001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001174 active site 264462001175 phosphorylation site [posttranslational modification] 264462001176 intermolecular recognition site; other site 264462001177 dimerization interface [polypeptide binding]; other site 264462001178 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264462001179 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264462001180 motif 1; other site 264462001181 active site 264462001182 motif 2; other site 264462001183 motif 3; other site 264462001184 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264462001185 recombination regulator RecX; Reviewed; Region: recX; PRK00117 264462001186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264462001187 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264462001188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264462001189 putative active site [active] 264462001190 putative metal binding site [ion binding]; other site 264462001191 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264462001192 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264462001193 acyl-activating enzyme (AAE) consensus motif; other site 264462001194 AMP binding site [chemical binding]; other site 264462001195 active site 264462001196 CoA binding site [chemical binding]; other site 264462001197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001199 substrate binding pocket [chemical binding]; other site 264462001200 membrane-bound complex binding site; other site 264462001201 hinge residues; other site 264462001202 short chain dehydrogenase; Provisional; Region: PRK08339 264462001203 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 264462001204 putative NAD(P) binding site [chemical binding]; other site 264462001205 putative active site [active] 264462001206 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264462001207 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264462001208 active site 264462001209 HIGH motif; other site 264462001210 dimer interface [polypeptide binding]; other site 264462001211 KMSKS motif; other site 264462001212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 264462001213 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 264462001214 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 264462001215 tetramer interfaces [polypeptide binding]; other site 264462001216 binuclear metal-binding site [ion binding]; other site 264462001217 Competence-damaged protein; Region: CinA; pfam02464 264462001218 recombinase A; Provisional; Region: recA; PRK09354 264462001219 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264462001220 hexamer interface [polypeptide binding]; other site 264462001221 Walker A motif; other site 264462001222 ATP binding site [chemical binding]; other site 264462001223 Walker B motif; other site 264462001224 Uncharacterized conserved protein [Function unknown]; Region: COG3189 264462001225 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 264462001226 3D domain; Region: 3D; cl01439 264462001227 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462001228 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264462001229 catalytic triad [active] 264462001230 putative active site [active] 264462001231 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264462001232 catalytic residues [active] 264462001233 dimer interface [polypeptide binding]; other site 264462001234 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 264462001235 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264462001236 putative nucleotide binding site [chemical binding]; other site 264462001237 putative catalytic residues [active] 264462001238 putative Mg ion binding site [ion binding]; other site 264462001239 putative aspartate binding site [chemical binding]; other site 264462001240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462001241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462001242 catalytic residue [active] 264462001243 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 264462001244 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264462001245 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 264462001246 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 264462001247 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264462001248 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264462001249 SAF-like; Region: SAF_2; pfam13144 264462001250 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264462001251 Flagellar L-ring protein; Region: FlgH; cl17277 264462001252 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 264462001253 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 264462001254 Rod binding protein; Region: Rod-binding; pfam10135 264462001255 Peptidase family M23; Region: Peptidase_M23; pfam01551 264462001256 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 264462001257 FlgN protein; Region: FlgN; pfam05130 264462001258 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 264462001259 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264462001260 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 264462001261 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462001262 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462001263 flagellar assembly protein FliW; Provisional; Region: PRK13285 264462001264 RmuC family; Region: RmuC; pfam02646 264462001265 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 264462001266 UbiA prenyltransferase family; Region: UbiA; pfam01040 264462001267 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 264462001268 metal binding site [ion binding]; metal-binding site 264462001269 substrate binding pocket [chemical binding]; other site 264462001270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264462001271 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264462001272 AMP binding site [chemical binding]; other site 264462001273 active site 264462001274 acyl-activating enzyme (AAE) consensus motif; other site 264462001275 CoA binding site [chemical binding]; other site 264462001276 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264462001277 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462001278 Flagellin N-methylase; Region: FliB; pfam03692 264462001279 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264462001280 active site 264462001281 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264462001282 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264462001283 substrate binding pocket [chemical binding]; other site 264462001284 chain length determination region; other site 264462001285 substrate-Mg2+ binding site; other site 264462001286 catalytic residues [active] 264462001287 aspartate-rich region 1; other site 264462001288 active site lid residues [active] 264462001289 aspartate-rich region 2; other site 264462001290 UbiA prenyltransferase family; Region: UbiA; pfam01040 264462001291 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 264462001292 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462001294 S-adenosylmethionine binding site [chemical binding]; other site 264462001295 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 264462001296 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 264462001297 dimer interface [polypeptide binding]; other site 264462001298 Citrate synthase; Region: Citrate_synt; pfam00285 264462001299 active site 264462001300 citrylCoA binding site [chemical binding]; other site 264462001301 oxalacetate/citrate binding site [chemical binding]; other site 264462001302 coenzyme A binding site [chemical binding]; other site 264462001303 catalytic triad [active] 264462001304 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462001305 cleavage site 264462001306 active site 264462001307 substrate binding sites [chemical binding]; other site 264462001308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264462001309 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462001310 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462001311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462001312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001313 active site 264462001314 phosphorylation site [posttranslational modification] 264462001315 intermolecular recognition site; other site 264462001316 dimerization interface [polypeptide binding]; other site 264462001317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462001318 DNA binding site [nucleotide binding] 264462001319 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 264462001320 nucleotide binding site/active site [active] 264462001321 HIT family signature motif; other site 264462001322 catalytic residue [active] 264462001323 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 264462001324 dimer interface [polypeptide binding]; other site 264462001325 substrate binding site [chemical binding]; other site 264462001326 metal binding sites [ion binding]; metal-binding site 264462001327 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 264462001328 Nitronate monooxygenase; Region: NMO; pfam03060 264462001329 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264462001330 FMN binding site [chemical binding]; other site 264462001331 substrate binding site [chemical binding]; other site 264462001332 putative catalytic residue [active] 264462001333 Imelysin; Region: Peptidase_M75; pfam09375 264462001334 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 264462001335 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 264462001336 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264462001337 putative binding surface; other site 264462001338 active site 264462001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462001340 ATP binding site [chemical binding]; other site 264462001341 Mg2+ binding site [ion binding]; other site 264462001342 G-X-G motif; other site 264462001343 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264462001344 CheW-like domain; Region: CheW; pfam01584 264462001345 CheD chemotactic sensory transduction; Region: CheD; cl00810 264462001346 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264462001347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001348 active site 264462001349 phosphorylation site [posttranslational modification] 264462001350 intermolecular recognition site; other site 264462001351 dimerization interface [polypeptide binding]; other site 264462001352 CheB methylesterase; Region: CheB_methylest; pfam01339 264462001353 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264462001354 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264462001355 NAD(P) binding site [chemical binding]; other site 264462001356 catalytic residues [active] 264462001357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462001358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462001359 dimerization interface [polypeptide binding]; other site 264462001360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462001361 dimer interface [polypeptide binding]; other site 264462001362 phosphorylation site [posttranslational modification] 264462001363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462001364 ATP binding site [chemical binding]; other site 264462001365 Mg2+ binding site [ion binding]; other site 264462001366 G-X-G motif; other site 264462001367 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462001368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001369 active site 264462001370 phosphorylation site [posttranslational modification] 264462001371 intermolecular recognition site; other site 264462001372 dimerization interface [polypeptide binding]; other site 264462001373 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 264462001374 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264462001375 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 264462001376 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 264462001377 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 264462001378 conserved cys residue [active] 264462001379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 264462001380 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 264462001381 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 264462001382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264462001383 minor groove reading motif; other site 264462001384 helix-hairpin-helix signature motif; other site 264462001385 substrate binding pocket [chemical binding]; other site 264462001386 active site 264462001387 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 264462001388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264462001389 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264462001390 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 264462001391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462001392 dimer interface [polypeptide binding]; other site 264462001393 conserved gate region; other site 264462001394 putative PBP binding loops; other site 264462001395 ABC-ATPase subunit interface; other site 264462001396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462001397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462001398 Walker A/P-loop; other site 264462001399 ATP binding site [chemical binding]; other site 264462001400 Q-loop/lid; other site 264462001401 ABC transporter signature motif; other site 264462001402 Walker B; other site 264462001403 D-loop; other site 264462001404 H-loop/switch region; other site 264462001405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462001406 dimerization interface [polypeptide binding]; other site 264462001407 PAS domain; Region: PAS_9; pfam13426 264462001408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462001409 putative active site [active] 264462001410 heme pocket [chemical binding]; other site 264462001411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462001412 dimer interface [polypeptide binding]; other site 264462001413 phosphorylation site [posttranslational modification] 264462001414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462001415 ATP binding site [chemical binding]; other site 264462001416 Mg2+ binding site [ion binding]; other site 264462001417 G-X-G motif; other site 264462001418 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001420 active site 264462001421 phosphorylation site [posttranslational modification] 264462001422 intermolecular recognition site; other site 264462001423 dimerization interface [polypeptide binding]; other site 264462001424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001426 substrate binding pocket [chemical binding]; other site 264462001427 membrane-bound complex binding site; other site 264462001428 hinge residues; other site 264462001429 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 264462001430 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 264462001431 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264462001432 flagellin; Provisional; Region: PRK12802 264462001433 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462001434 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462001435 Transposase IS200 like; Region: Y1_Tnp; cl00848 264462001436 flagellin; Provisional; Region: PRK12802 264462001437 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462001438 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462001439 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 264462001440 active site 264462001441 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 264462001442 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 264462001443 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 264462001444 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264462001445 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264462001446 Flagellar protein FliS; Region: FliS; cl00654 264462001447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001448 TPR motif; other site 264462001449 binding surface 264462001450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462001451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001452 binding surface 264462001453 TPR repeat; Region: TPR_11; pfam13414 264462001454 TPR motif; other site 264462001455 TPR repeat; Region: TPR_11; pfam13414 264462001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264462001457 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462001458 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462001459 putative active site [active] 264462001460 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462001461 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462001462 putative active site [active] 264462001463 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264462001464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462001465 dimer interface [polypeptide binding]; other site 264462001466 phosphorylation site [posttranslational modification] 264462001467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462001468 ATP binding site [chemical binding]; other site 264462001469 Mg2+ binding site [ion binding]; other site 264462001470 G-X-G motif; other site 264462001471 Response regulator receiver domain; Region: Response_reg; pfam00072 264462001472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462001473 active site 264462001474 phosphorylation site [posttranslational modification] 264462001475 intermolecular recognition site; other site 264462001476 dimerization interface [polypeptide binding]; other site 264462001477 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 264462001478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462001479 S-adenosylmethionine binding site [chemical binding]; other site 264462001480 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264462001481 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264462001482 active site 264462001483 (T/H)XGH motif; other site 264462001484 aspartate aminotransferase; Provisional; Region: PRK05764 264462001485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264462001486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462001487 homodimer interface [polypeptide binding]; other site 264462001488 catalytic residue [active] 264462001489 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 264462001490 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462001491 cleavage site 264462001492 active site 264462001493 substrate binding sites [chemical binding]; other site 264462001494 Protein of unknown function (DUF502); Region: DUF502; pfam04367 264462001495 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 264462001496 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 264462001497 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462001498 ligand binding site [chemical binding]; other site 264462001499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 264462001500 Tetratricopeptide repeat; Region: TPR_6; pfam13174 264462001501 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 264462001502 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264462001503 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 264462001504 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 264462001505 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264462001506 SmpB-tmRNA interface; other site 264462001507 PilZ domain; Region: PilZ; pfam07238 264462001508 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 264462001509 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 264462001510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264462001511 MarR family; Region: MarR_2; cl17246 264462001512 Domain of unknown function (DUF336); Region: DUF336; cl01249 264462001513 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264462001514 active site 264462001515 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264462001516 putative substrate binding site [chemical binding]; other site 264462001517 putative ATP binding site [chemical binding]; other site 264462001518 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 264462001519 putative active site [active] 264462001520 putative CoA binding site [chemical binding]; other site 264462001521 nudix motif; other site 264462001522 metal binding site [ion binding]; metal-binding site 264462001523 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 264462001524 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264462001525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264462001526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462001527 putative substrate translocation pore; other site 264462001528 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264462001529 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 264462001530 TrkA-N domain; Region: TrkA_N; pfam02254 264462001531 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 264462001532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462001533 dimer interface [polypeptide binding]; other site 264462001534 putative CheW interface [polypeptide binding]; other site 264462001535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264462001536 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264462001537 substrate binding pocket [chemical binding]; other site 264462001538 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 264462001539 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 264462001540 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264462001541 active site 264462001542 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 264462001543 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001545 substrate binding pocket [chemical binding]; other site 264462001546 membrane-bound complex binding site; other site 264462001547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001548 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001549 substrate binding pocket [chemical binding]; other site 264462001550 membrane-bound complex binding site; other site 264462001551 hinge residues; other site 264462001552 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264462001553 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 264462001554 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 264462001555 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 264462001556 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 264462001557 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264462001558 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264462001559 HSP70 interaction site [polypeptide binding]; other site 264462001560 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462001561 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264462001562 lipoyl attachment site [posttranslational modification]; other site 264462001563 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264462001564 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264462001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264462001566 Family of unknown function (DUF633); Region: DUF633; pfam04816 264462001567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462001568 salt bridge; other site 264462001569 non-specific DNA binding site [nucleotide binding]; other site 264462001570 sequence-specific DNA binding site [nucleotide binding]; other site 264462001571 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 264462001572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001573 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001574 substrate binding pocket [chemical binding]; other site 264462001575 membrane-bound complex binding site; other site 264462001576 hinge residues; other site 264462001577 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 264462001578 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462001579 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462001580 putative active site [active] 264462001581 glycine dehydrogenase; Provisional; Region: PRK05367 264462001582 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264462001583 tetramer interface [polypeptide binding]; other site 264462001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462001585 catalytic residue [active] 264462001586 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264462001587 tetramer interface [polypeptide binding]; other site 264462001588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462001589 catalytic residue [active] 264462001590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462001591 putative substrate translocation pore; other site 264462001592 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264462001593 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462001594 putative active site [active] 264462001595 catalytic site [active] 264462001596 PLD-like domain; Region: PLDc_2; pfam13091 264462001597 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462001598 putative active site [active] 264462001599 catalytic site [active] 264462001600 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 264462001601 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264462001602 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264462001603 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264462001604 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 264462001605 motif 1; other site 264462001606 dimer interface [polypeptide binding]; other site 264462001607 active site 264462001608 motif 2; other site 264462001609 motif 3; other site 264462001610 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462001611 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462001612 Septum formation initiator; Region: DivIC; cl17659 264462001613 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 264462001614 cleavage site 264462001615 active site 264462001616 substrate binding sites [chemical binding]; other site 264462001617 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264462001618 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264462001619 E3 interaction surface; other site 264462001620 lipoyl attachment site [posttranslational modification]; other site 264462001621 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264462001622 carboxyltransferase (CT) interaction site; other site 264462001623 biotinylation site [posttranslational modification]; other site 264462001624 HlyD family secretion protein; Region: HlyD_3; pfam13437 264462001625 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 264462001626 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462001627 Walker A/P-loop; other site 264462001628 ATP binding site [chemical binding]; other site 264462001629 Q-loop/lid; other site 264462001630 ABC transporter signature motif; other site 264462001631 Walker B; other site 264462001632 D-loop; other site 264462001633 H-loop/switch region; other site 264462001634 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462001635 FtsX-like permease family; Region: FtsX; pfam02687 264462001636 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264462001637 IHF - DNA interface [nucleotide binding]; other site 264462001638 IHF dimer interface [polypeptide binding]; other site 264462001639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264462001640 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264462001641 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264462001642 active site 264462001643 8-oxo-dGMP binding site [chemical binding]; other site 264462001644 nudix motif; other site 264462001645 metal binding site [ion binding]; metal-binding site 264462001646 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 264462001647 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 264462001648 quinone interaction residues [chemical binding]; other site 264462001649 active site 264462001650 catalytic residues [active] 264462001651 FMN binding site [chemical binding]; other site 264462001652 substrate binding site [chemical binding]; other site 264462001653 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 264462001654 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264462001655 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 264462001656 NAD(P) binding site [chemical binding]; other site 264462001657 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 264462001658 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 264462001659 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 264462001660 putative ribose interaction site [chemical binding]; other site 264462001661 putative ADP binding site [chemical binding]; other site 264462001662 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 264462001663 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264462001664 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264462001665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462001666 salt bridge; other site 264462001667 non-specific DNA binding site [nucleotide binding]; other site 264462001668 sequence-specific DNA binding site [nucleotide binding]; other site 264462001669 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462001670 NHL repeat; Region: NHL; pfam01436 264462001671 NHL repeat; Region: NHL; pfam01436 264462001672 NHL repeat; Region: NHL; pfam01436 264462001673 NHL repeat; Region: NHL; pfam01436 264462001674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001676 substrate binding pocket [chemical binding]; other site 264462001677 membrane-bound complex binding site; other site 264462001678 hinge residues; other site 264462001679 KH domain; Region: KH_4; pfam13083 264462001680 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462001681 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264462001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462001683 putative substrate translocation pore; other site 264462001684 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 264462001685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462001686 FeS/SAM binding site; other site 264462001687 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 264462001688 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264462001689 substrate binding site [chemical binding]; other site 264462001690 ATP binding site [chemical binding]; other site 264462001691 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264462001692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462001693 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264462001694 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 264462001695 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264462001696 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264462001697 putative active site [active] 264462001698 putative metal binding site [ion binding]; other site 264462001699 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 264462001700 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264462001701 active site 264462001702 dimer interface [polypeptide binding]; other site 264462001703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264462001704 dimer interface [polypeptide binding]; other site 264462001705 active site 264462001706 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001707 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462001708 phosphopeptide binding site; other site 264462001709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264462001710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264462001711 metal binding site [ion binding]; metal-binding site 264462001712 active site 264462001713 I-site; other site 264462001714 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 264462001715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462001716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462001717 DNA binding residues [nucleotide binding] 264462001718 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 264462001719 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462001720 methionine sulfoxide reductase B; Provisional; Region: PRK00222 264462001721 SelR domain; Region: SelR; pfam01641 264462001722 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 264462001723 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264462001724 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 264462001725 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 264462001726 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 264462001727 putative active site [active] 264462001728 PhoH-like protein; Region: PhoH; pfam02562 264462001729 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264462001730 dimer interaction site [polypeptide binding]; other site 264462001731 substrate-binding tunnel; other site 264462001732 active site 264462001733 catalytic site [active] 264462001734 substrate binding site [chemical binding]; other site 264462001735 Sensors of blue-light using FAD; Region: BLUF; pfam04940 264462001736 Predicted membrane protein [Function unknown]; Region: COG2259 264462001737 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264462001738 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 264462001739 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 264462001740 SdiA-regulated; Region: SdiA-regulated; cd09971 264462001741 SdiA-regulated; Region: SdiA-regulated; pfam06977 264462001742 putative active site [active] 264462001743 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 264462001744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001745 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001746 substrate binding pocket [chemical binding]; other site 264462001747 membrane-bound complex binding site; other site 264462001748 hinge residues; other site 264462001749 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 264462001750 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 264462001751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462001752 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264462001753 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 264462001754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264462001755 E3 interaction surface; other site 264462001756 lipoyl attachment site [posttranslational modification]; other site 264462001757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264462001758 E3 interaction surface; other site 264462001759 lipoyl attachment site [posttranslational modification]; other site 264462001760 e3 binding domain; Region: E3_binding; pfam02817 264462001761 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264462001762 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 264462001763 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 264462001764 HEPN domain; Region: HEPN; pfam05168 264462001765 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264462001766 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264462001767 Type II/IV secretion system protein; Region: T2SE; pfam00437 264462001768 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264462001769 ATP binding site [chemical binding]; other site 264462001770 Walker A motif; other site 264462001771 hexamer interface [polypeptide binding]; other site 264462001772 Walker B motif; other site 264462001773 enolase; Provisional; Region: eno; PRK00077 264462001774 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264462001775 dimer interface [polypeptide binding]; other site 264462001776 metal binding site [ion binding]; metal-binding site 264462001777 substrate binding pocket [chemical binding]; other site 264462001778 Cupin domain; Region: Cupin_2; cl17218 264462001779 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 264462001780 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 264462001781 tetramer interface [polypeptide binding]; other site 264462001782 heme binding pocket [chemical binding]; other site 264462001783 NADPH binding site [chemical binding]; other site 264462001784 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264462001785 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264462001786 Septum formation initiator; Region: DivIC; pfam04977 264462001787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462001788 non-specific DNA binding site [nucleotide binding]; other site 264462001789 salt bridge; other site 264462001790 sequence-specific DNA binding site [nucleotide binding]; other site 264462001791 DNA polymerase I; Provisional; Region: PRK05755 264462001792 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264462001793 active site 264462001794 metal binding site 1 [ion binding]; metal-binding site 264462001795 putative 5' ssDNA interaction site; other site 264462001796 metal binding site 3; metal-binding site 264462001797 metal binding site 2 [ion binding]; metal-binding site 264462001798 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264462001799 putative DNA binding site [nucleotide binding]; other site 264462001800 putative metal binding site [ion binding]; other site 264462001801 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264462001802 active site 264462001803 DNA binding site [nucleotide binding] 264462001804 catalytic site [active] 264462001805 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 264462001806 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001807 phosphopeptide binding site; other site 264462001808 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264462001809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462001810 Walker A motif; other site 264462001811 ATP binding site [chemical binding]; other site 264462001812 Walker B motif; other site 264462001813 arginine finger; other site 264462001814 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462001815 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264462001816 G1 box; other site 264462001817 GTP/Mg2+ binding site [chemical binding]; other site 264462001818 Switch I region; other site 264462001819 G2 box; other site 264462001820 G3 box; other site 264462001821 Switch II region; other site 264462001822 G4 box; other site 264462001823 G5 box; other site 264462001824 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 264462001825 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264462001826 Ligand binding site; other site 264462001827 oligomer interface; other site 264462001828 CTP synthetase; Validated; Region: pyrG; PRK05380 264462001829 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264462001830 Catalytic site [active] 264462001831 active site 264462001832 UTP binding site [chemical binding]; other site 264462001833 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264462001834 active site 264462001835 putative oxyanion hole; other site 264462001836 catalytic triad [active] 264462001837 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 264462001838 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264462001839 putative active site [active] 264462001840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264462001841 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264462001842 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 264462001843 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 264462001844 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264462001845 active site 264462001846 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264462001847 Bacterial SH3 domain; Region: SH3_5; pfam08460 264462001848 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264462001849 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 264462001850 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264462001851 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 264462001852 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 264462001853 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 264462001854 putative metal binding residues [ion binding]; other site 264462001855 signature motif; other site 264462001856 dimer interface [polypeptide binding]; other site 264462001857 active site 264462001858 polyP binding site; other site 264462001859 substrate binding site [chemical binding]; other site 264462001860 acceptor-phosphate pocket; other site 264462001861 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264462001862 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264462001863 Walker A/P-loop; other site 264462001864 ATP binding site [chemical binding]; other site 264462001865 Q-loop/lid; other site 264462001866 ABC transporter signature motif; other site 264462001867 Walker B; other site 264462001868 D-loop; other site 264462001869 H-loop/switch region; other site 264462001870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264462001871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462001872 dimer interface [polypeptide binding]; other site 264462001873 conserved gate region; other site 264462001874 putative PBP binding loops; other site 264462001875 ABC-ATPase subunit interface; other site 264462001876 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001878 substrate binding pocket [chemical binding]; other site 264462001879 membrane-bound complex binding site; other site 264462001880 hinge residues; other site 264462001881 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 264462001882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462001883 active site 264462001884 motif I; other site 264462001885 motif II; other site 264462001886 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 264462001887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001888 binding surface 264462001889 TPR motif; other site 264462001890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001891 TPR motif; other site 264462001892 binding surface 264462001893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001894 TPR motif; other site 264462001895 TPR repeat; Region: TPR_11; pfam13414 264462001896 binding surface 264462001897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462001898 binding surface 264462001899 TPR motif; other site 264462001900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462001901 TPR repeat; Region: TPR_11; pfam13414 264462001902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264462001903 binding surface 264462001904 TPR motif; other site 264462001905 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462001906 phosphopeptide binding site; other site 264462001907 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264462001908 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264462001909 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462001910 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462001911 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 264462001912 OstA-like protein; Region: OstA; cl00844 264462001913 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264462001914 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 264462001915 Walker A/P-loop; other site 264462001916 ATP binding site [chemical binding]; other site 264462001917 Q-loop/lid; other site 264462001918 ABC transporter signature motif; other site 264462001919 Walker B; other site 264462001920 D-loop; other site 264462001921 H-loop/switch region; other site 264462001922 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264462001923 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264462001924 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264462001925 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264462001926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462001928 substrate binding pocket [chemical binding]; other site 264462001929 membrane-bound complex binding site; other site 264462001930 hinge residues; other site 264462001931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462001932 active site 264462001933 nucleosidase; Provisional; Region: PRK05634 264462001934 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264462001935 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264462001936 30S subunit binding site; other site 264462001937 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264462001938 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264462001939 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264462001940 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264462001941 GTP-binding protein LepA; Provisional; Region: PRK05433 264462001942 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264462001943 G1 box; other site 264462001944 putative GEF interaction site [polypeptide binding]; other site 264462001945 GTP/Mg2+ binding site [chemical binding]; other site 264462001946 Switch I region; other site 264462001947 G2 box; other site 264462001948 G3 box; other site 264462001949 Switch II region; other site 264462001950 G4 box; other site 264462001951 G5 box; other site 264462001952 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264462001953 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264462001954 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264462001955 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264462001956 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001957 Catalytic site [active] 264462001958 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001959 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264462001960 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001961 Catalytic site [active] 264462001962 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001963 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264462001964 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001965 Catalytic site [active] 264462001966 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264462001967 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264462001968 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264462001969 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264462001970 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264462001971 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 264462001972 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264462001973 catalytic site [active] 264462001974 subunit interface [polypeptide binding]; other site 264462001975 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264462001976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264462001977 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264462001978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264462001979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264462001980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264462001981 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264462001982 IMP binding site; other site 264462001983 dimer interface [polypeptide binding]; other site 264462001984 interdomain contacts; other site 264462001985 partial ornithine binding site; other site 264462001986 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 264462001987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462001988 substrate binding pocket [chemical binding]; other site 264462001989 membrane-bound complex binding site; other site 264462001990 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264462001991 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264462001992 Walker A/P-loop; other site 264462001993 ATP binding site [chemical binding]; other site 264462001994 Q-loop/lid; other site 264462001995 ABC transporter signature motif; other site 264462001996 Walker B; other site 264462001997 D-loop; other site 264462001998 H-loop/switch region; other site 264462001999 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 264462002000 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 264462002001 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264462002002 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264462002003 Cell division protein FtsA; Region: FtsA; cl17206 264462002004 Competence protein A; Region: Competence_A; pfam11104 264462002005 Cell division protein FtsA; Region: FtsA; pfam14450 264462002006 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 264462002007 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264462002008 Pilus assembly protein, PilO; Region: PilO; cl01234 264462002009 Pilus assembly protein, PilP; Region: PilP; pfam04351 264462002010 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 264462002011 Secretin and TonB N terminus short domain; Region: STN; pfam07660 264462002012 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264462002013 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264462002014 recombination factor protein RarA; Reviewed; Region: PRK13342 264462002015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462002016 Walker A motif; other site 264462002017 ATP binding site [chemical binding]; other site 264462002018 Walker B motif; other site 264462002019 arginine finger; other site 264462002020 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264462002021 Cupin domain; Region: Cupin_2; pfam07883 264462002022 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462002023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462002024 FliG C-terminal domain; Region: FliG_C; pfam01706 264462002025 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 264462002026 putative substrate binding pocket [chemical binding]; other site 264462002027 AC domain interface; other site 264462002028 catalytic triad [active] 264462002029 AB domain interface; other site 264462002030 interchain disulfide; other site 264462002031 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 264462002032 dimer interface [polypeptide binding]; other site 264462002033 RNA polymerase sigma factor; Provisional; Region: PRK12518 264462002034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462002035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462002036 DNA binding residues [nucleotide binding] 264462002037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264462002038 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462002039 ligand binding site [chemical binding]; other site 264462002040 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462002041 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 264462002042 Bacterial SH3 domain; Region: SH3_3; cl17532 264462002043 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264462002044 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462002045 Protein export membrane protein; Region: SecD_SecF; cl14618 264462002046 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 264462002047 aromatic arch; other site 264462002048 DCoH dimer interaction site [polypeptide binding]; other site 264462002049 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264462002050 DCoH tetramer interaction site [polypeptide binding]; other site 264462002051 substrate binding site [chemical binding]; other site 264462002052 Protein of unknown function DUF72; Region: DUF72; pfam01904 264462002053 BON domain; Region: BON; pfam04972 264462002054 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264462002055 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 264462002056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462002058 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264462002059 putative effector binding pocket; other site 264462002060 dimerization interface [polypeptide binding]; other site 264462002061 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264462002062 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 264462002063 substrate binding site [chemical binding]; other site 264462002064 catalytic Zn binding site [ion binding]; other site 264462002065 NAD binding site [chemical binding]; other site 264462002066 structural Zn binding site [ion binding]; other site 264462002067 dimer interface [polypeptide binding]; other site 264462002068 S-formylglutathione hydrolase; Region: PLN02442 264462002069 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 264462002070 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264462002071 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 264462002072 putative NAD(P) binding site [chemical binding]; other site 264462002073 putative substrate binding site [chemical binding]; other site 264462002074 catalytic Zn binding site [ion binding]; other site 264462002075 structural Zn binding site [ion binding]; other site 264462002076 dimer interface [polypeptide binding]; other site 264462002077 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264462002078 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 264462002079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462002081 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264462002082 putative effector binding pocket; other site 264462002083 putative dimerization interface [polypeptide binding]; other site 264462002084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462002086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462002087 dimerization interface [polypeptide binding]; other site 264462002088 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 264462002089 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264462002090 ABC1 family; Region: ABC1; cl17513 264462002091 Protein of unknown function, DUF393; Region: DUF393; pfam04134 264462002092 TIGR03643 family protein; Region: TIGR03643 264462002093 Predicted transcriptional regulators [Transcription]; Region: COG1510 264462002094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264462002095 dimerization interface [polypeptide binding]; other site 264462002096 putative DNA binding site [nucleotide binding]; other site 264462002097 putative Zn2+ binding site [ion binding]; other site 264462002098 OsmC-like protein; Region: OsmC; pfam02566 264462002099 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462002100 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 264462002101 putative NAD(P) binding site [chemical binding]; other site 264462002102 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264462002103 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 264462002104 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264462002105 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264462002106 Walker A/P-loop; other site 264462002107 ATP binding site [chemical binding]; other site 264462002108 Q-loop/lid; other site 264462002109 ABC transporter signature motif; other site 264462002110 Walker B; other site 264462002111 D-loop; other site 264462002112 H-loop/switch region; other site 264462002113 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 264462002114 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 264462002115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264462002116 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 264462002117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462002118 motif II; other site 264462002119 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264462002120 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264462002121 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264462002122 putative dimer interface [polypeptide binding]; other site 264462002123 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462002124 active site residue [active] 264462002125 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264462002126 FOG: CBS domain [General function prediction only]; Region: COG0517 264462002127 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 264462002128 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264462002129 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264462002130 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462002131 protein binding site [polypeptide binding]; other site 264462002132 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462002133 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264462002134 Peptidase family U32; Region: Peptidase_U32; pfam01136 264462002135 Collagenase; Region: DUF3656; pfam12392 264462002136 Peptidase family U32; Region: Peptidase_U32; cl03113 264462002137 Chorismate mutase type II; Region: CM_2; smart00830 264462002138 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264462002139 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264462002140 putative RNA binding site [nucleotide binding]; other site 264462002141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462002142 S-adenosylmethionine binding site [chemical binding]; other site 264462002143 Cupin superfamily protein; Region: Cupin_4; pfam08007 264462002144 Cupin-like domain; Region: Cupin_8; pfam13621 264462002145 malate dehydrogenase; Provisional; Region: PRK05442 264462002146 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 264462002147 NAD(P) binding site [chemical binding]; other site 264462002148 dimer interface [polypeptide binding]; other site 264462002149 malate binding site [chemical binding]; other site 264462002150 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264462002151 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264462002152 conserved cys residue [active] 264462002153 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 264462002154 DNA binding residues [nucleotide binding] 264462002155 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264462002156 B12 binding domain; Region: B12-binding_2; pfam02607 264462002157 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 264462002158 B12 binding site [chemical binding]; other site 264462002159 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462002160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462002161 dimer interface [polypeptide binding]; other site 264462002162 putative CheW interface [polypeptide binding]; other site 264462002163 Endonuclease I; Region: Endonuclease_1; pfam04231 264462002164 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 264462002165 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264462002166 RNA binding site [nucleotide binding]; other site 264462002167 nitrilase; Region: PLN02798 264462002168 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 264462002169 putative active site [active] 264462002170 catalytic triad [active] 264462002171 dimer interface [polypeptide binding]; other site 264462002172 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264462002173 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 264462002174 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 264462002175 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 264462002176 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264462002177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264462002178 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264462002179 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264462002180 trimer interface [polypeptide binding]; other site 264462002181 active site 264462002182 UDP-GlcNAc binding site [chemical binding]; other site 264462002183 lipid binding site [chemical binding]; lipid-binding site 264462002184 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264462002185 rRNA binding site [nucleotide binding]; other site 264462002186 predicted 30S ribosome binding site; other site 264462002187 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264462002188 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264462002189 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 264462002190 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264462002191 RNA binding site [nucleotide binding]; other site 264462002192 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264462002193 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264462002194 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 264462002195 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 264462002196 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264462002197 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 264462002198 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264462002199 active site 264462002200 interdomain interaction site; other site 264462002201 putative metal-binding site [ion binding]; other site 264462002202 nucleotide binding site [chemical binding]; other site 264462002203 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 264462002204 domain I; other site 264462002205 phosphate binding site [ion binding]; other site 264462002206 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264462002207 domain II; other site 264462002208 domain III; other site 264462002209 nucleotide binding site [chemical binding]; other site 264462002210 DNA binding groove [nucleotide binding] 264462002211 catalytic site [active] 264462002212 domain IV; other site 264462002213 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264462002214 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264462002215 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264462002216 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 264462002217 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264462002218 C-terminal peptidase (prc); Region: prc; TIGR00225 264462002219 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264462002220 protein binding site [polypeptide binding]; other site 264462002221 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264462002222 Catalytic dyad [active] 264462002223 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 264462002224 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462002225 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 264462002226 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264462002227 tetramer interface [polypeptide binding]; other site 264462002228 TPP-binding site [chemical binding]; other site 264462002229 heterodimer interface [polypeptide binding]; other site 264462002230 phosphorylation loop region [posttranslational modification] 264462002231 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264462002232 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264462002233 dimer interface [polypeptide binding]; other site 264462002234 PYR/PP interface [polypeptide binding]; other site 264462002235 TPP binding site [chemical binding]; other site 264462002236 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264462002237 S-adenosylmethionine binding site [chemical binding]; other site 264462002238 Methyltransferase domain; Region: Methyltransf_18; pfam12847 264462002239 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 264462002240 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 264462002241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462002242 active site 264462002243 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 264462002244 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264462002245 Domain of unknown function DUF21; Region: DUF21; pfam01595 264462002246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264462002247 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264462002248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462002249 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 264462002250 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264462002251 elongation factor G; Reviewed; Region: PRK12740 264462002252 G1 box; other site 264462002253 putative GEF interaction site [polypeptide binding]; other site 264462002254 GTP/Mg2+ binding site [chemical binding]; other site 264462002255 Switch I region; other site 264462002256 G2 box; other site 264462002257 G3 box; other site 264462002258 Switch II region; other site 264462002259 G4 box; other site 264462002260 G5 box; other site 264462002261 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 264462002262 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264462002263 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 264462002264 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 264462002265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462002266 ATP binding site [chemical binding]; other site 264462002267 putative Mg++ binding site [ion binding]; other site 264462002268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462002269 nucleotide binding region [chemical binding]; other site 264462002270 ATP-binding site [chemical binding]; other site 264462002271 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 264462002272 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 264462002273 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 264462002274 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 264462002275 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 264462002276 NodB motif; other site 264462002277 putative active site [active] 264462002278 putative catalytic site [active] 264462002279 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 264462002280 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264462002281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462002282 ABC transporter; Region: ABC_tran_2; pfam12848 264462002283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462002284 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264462002285 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264462002286 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264462002287 Outer membrane efflux protein; Region: OEP; pfam02321 264462002288 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462002289 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 264462002290 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 264462002291 DNA binding residues [nucleotide binding] 264462002292 dimer interface [polypeptide binding]; other site 264462002293 [2Fe-2S] cluster binding site [ion binding]; other site 264462002294 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 264462002295 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264462002296 putative active site [active] 264462002297 metal binding site [ion binding]; metal-binding site 264462002298 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264462002299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462002301 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264462002302 putative effector binding pocket; other site 264462002303 dimerization interface [polypeptide binding]; other site 264462002304 PilZ domain; Region: PilZ; pfam07238 264462002305 thiamine monophosphate kinase; Provisional; Region: PRK05731 264462002306 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264462002307 ATP binding site [chemical binding]; other site 264462002308 dimerization interface [polypeptide binding]; other site 264462002309 polyphosphate kinase; Provisional; Region: PRK05443 264462002310 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264462002311 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264462002312 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 264462002313 putative domain interface [polypeptide binding]; other site 264462002314 putative active site [active] 264462002315 catalytic site [active] 264462002316 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264462002317 putative domain interface [polypeptide binding]; other site 264462002318 putative active site [active] 264462002319 catalytic site [active] 264462002320 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264462002321 catalytic core [active] 264462002322 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 264462002323 Transposase IS200 like; Region: Y1_Tnp; cl00848 264462002324 exopolyphosphatase; Region: exo_poly_only; TIGR03706 264462002325 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 264462002326 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 264462002327 PhoU domain; Region: PhoU; pfam01895 264462002328 PhoU domain; Region: PhoU; pfam01895 264462002329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462002330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462002331 active site 264462002332 phosphorylation site [posttranslational modification] 264462002333 intermolecular recognition site; other site 264462002334 dimerization interface [polypeptide binding]; other site 264462002335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462002336 DNA binding site [nucleotide binding] 264462002337 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462002338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462002339 dimer interface [polypeptide binding]; other site 264462002340 phosphorylation site [posttranslational modification] 264462002341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462002342 ATP binding site [chemical binding]; other site 264462002343 Mg2+ binding site [ion binding]; other site 264462002344 G-X-G motif; other site 264462002345 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 264462002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462002347 S-adenosylmethionine binding site [chemical binding]; other site 264462002348 Domain of unknown function (DUF814); Region: DUF814; pfam05670 264462002349 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 264462002350 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264462002351 Walker A/P-loop; other site 264462002352 ATP binding site [chemical binding]; other site 264462002353 Q-loop/lid; other site 264462002354 ABC transporter signature motif; other site 264462002355 Walker B; other site 264462002356 D-loop; other site 264462002357 H-loop/switch region; other site 264462002358 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 264462002359 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 264462002360 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 264462002361 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 264462002362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264462002363 Protein of unknown function (DUF429); Region: DUF429; pfam04250 264462002364 hypothetical protein; Provisional; Region: PRK08317 264462002365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462002366 S-adenosylmethionine binding site [chemical binding]; other site 264462002367 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264462002368 Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832 264462002369 oligomer interface [polypeptide binding]; other site 264462002370 metal binding site [ion binding]; metal-binding site 264462002371 putative Cl binding site [ion binding]; other site 264462002372 basic sphincter; other site 264462002373 hydrophobic gate; other site 264462002374 periplasmic entrance; other site 264462002375 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462002376 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264462002377 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462002378 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 264462002379 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264462002380 thymidylate kinase; Validated; Region: tmk; PRK00698 264462002381 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264462002382 TMP-binding site; other site 264462002383 ATP-binding site [chemical binding]; other site 264462002384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462002385 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 264462002386 Walker A motif; other site 264462002387 ATP binding site [chemical binding]; other site 264462002388 Walker B motif; other site 264462002389 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 264462002390 arginine finger; other site 264462002391 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 264462002392 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264462002393 active site 264462002394 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462002395 active site 264462002396 substrate binding sites [chemical binding]; other site 264462002397 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 264462002398 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 264462002399 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 264462002400 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264462002401 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 264462002402 Phosphoglycerate kinase; Region: PGK; pfam00162 264462002403 substrate binding site [chemical binding]; other site 264462002404 hinge regions; other site 264462002405 ADP binding site [chemical binding]; other site 264462002406 catalytic site [active] 264462002407 triosephosphate isomerase; Provisional; Region: PRK14565 264462002408 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264462002409 substrate binding site [chemical binding]; other site 264462002410 dimer interface [polypeptide binding]; other site 264462002411 catalytic triad [active] 264462002412 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 264462002413 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 264462002414 putative dimer interface [polypeptide binding]; other site 264462002415 putative anticodon binding site; other site 264462002416 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 264462002417 homodimer interface [polypeptide binding]; other site 264462002418 motif 1; other site 264462002419 motif 2; other site 264462002420 active site 264462002421 motif 3; other site 264462002422 threonine dehydratase; Provisional; Region: PRK08198 264462002423 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264462002424 tetramer interface [polypeptide binding]; other site 264462002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462002426 catalytic residue [active] 264462002427 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 264462002428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462002429 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264462002430 substrate binding pocket [chemical binding]; other site 264462002431 membrane-bound complex binding site; other site 264462002432 hinge residues; other site 264462002433 methionine sulfoxide reductase A; Provisional; Region: PRK14054 264462002434 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264462002435 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264462002436 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 264462002437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264462002438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462002439 homodimer interface [polypeptide binding]; other site 264462002440 catalytic residue [active] 264462002441 cytidylate kinase; Provisional; Region: cmk; PRK00023 264462002442 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264462002443 CMP-binding site; other site 264462002444 The sites determining sugar specificity; other site 264462002445 conserved hypothetical protein; Region: TIGR02285 264462002446 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 264462002447 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 264462002448 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264462002449 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264462002450 RNA binding site [nucleotide binding]; other site 264462002451 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264462002452 RNA binding site [nucleotide binding]; other site 264462002453 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 264462002454 RNA binding site [nucleotide binding]; other site 264462002455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264462002456 RNA binding site [nucleotide binding]; other site 264462002457 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264462002458 RNA binding site [nucleotide binding]; other site 264462002459 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 264462002460 RNA binding site [nucleotide binding]; other site 264462002461 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 264462002462 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264462002463 tandem repeat interface [polypeptide binding]; other site 264462002464 oligomer interface [polypeptide binding]; other site 264462002465 active site residues [active] 264462002466 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 264462002467 nucleotide binding site/active site [active] 264462002468 HIT family signature motif; other site 264462002469 catalytic residue [active] 264462002470 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 264462002471 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264462002472 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264462002473 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462002474 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 264462002475 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264462002476 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264462002477 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264462002478 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264462002479 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264462002480 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264462002481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462002483 dimerization interface [polypeptide binding]; other site 264462002484 Cache domain; Region: Cache_1; pfam02743 264462002485 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462002486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462002487 dimer interface [polypeptide binding]; other site 264462002488 putative CheW interface [polypeptide binding]; other site 264462002489 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 264462002490 Zn binding site [ion binding]; other site 264462002491 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 264462002492 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 264462002493 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 264462002494 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 264462002495 putative RNA binding site [nucleotide binding]; other site 264462002496 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264462002497 ATP cone domain; Region: ATP-cone; pfam03477 264462002498 16S rRNA methyltransferase B; Provisional; Region: PRK14902 264462002499 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 264462002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462002501 S-adenosylmethionine binding site [chemical binding]; other site 264462002502 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 264462002503 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 264462002504 histidyl-tRNA synthetase; Region: hisS; TIGR00442 264462002505 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264462002506 dimer interface [polypeptide binding]; other site 264462002507 motif 1; other site 264462002508 active site 264462002509 motif 2; other site 264462002510 motif 3; other site 264462002511 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 264462002512 anticodon binding site; other site 264462002513 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 264462002514 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 264462002515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462002516 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462002517 Walker A/P-loop; other site 264462002518 ATP binding site [chemical binding]; other site 264462002519 Q-loop/lid; other site 264462002520 ABC transporter signature motif; other site 264462002521 Walker B; other site 264462002522 D-loop; other site 264462002523 H-loop/switch region; other site 264462002524 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264462002525 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462002526 FtsX-like permease family; Region: FtsX; pfam02687 264462002527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462002528 dimerization interface [polypeptide binding]; other site 264462002529 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264462002530 cyclase homology domain; Region: CHD; cd07302 264462002531 nucleotidyl binding site; other site 264462002532 metal binding site [ion binding]; metal-binding site 264462002533 dimer interface [polypeptide binding]; other site 264462002534 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462002535 Interdomain contacts; other site 264462002536 Cytokine receptor motif; other site 264462002537 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 264462002538 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264462002539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264462002540 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 264462002541 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 264462002542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264462002543 active site 264462002544 TIGR03663 family protein; Region: TIGR03663 264462002545 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264462002546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462002547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462002548 catalytic residue [active] 264462002549 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264462002550 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462002551 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462002552 catalytic residue [active] 264462002553 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264462002554 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264462002555 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264462002556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264462002557 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264462002558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264462002559 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462002560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462002561 dimer interface [polypeptide binding]; other site 264462002562 putative CheW interface [polypeptide binding]; other site 264462002563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462002564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462002565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462002566 dimerization interface [polypeptide binding]; other site 264462002567 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462002568 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264462002569 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264462002570 homodimer interface [polypeptide binding]; other site 264462002571 substrate-cofactor binding pocket; other site 264462002572 catalytic residue [active] 264462002573 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264462002574 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 264462002575 heterodimerization interface [polypeptide binding]; other site 264462002576 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462002577 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462002578 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462002579 OsmC-like protein; Region: OsmC; pfam02566 264462002580 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 264462002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 264462002582 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462002583 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 264462002584 glycyl-tRNA synthetase; Provisional; Region: PRK04173 264462002585 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264462002586 motif 1; other site 264462002587 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 264462002588 active site 264462002589 motif 2; other site 264462002590 motif 3; other site 264462002591 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 264462002592 anticodon binding site; other site 264462002593 pyruvate phosphate dikinase; Provisional; Region: PRK09279 264462002594 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264462002595 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264462002596 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264462002597 mce related protein; Region: MCE; pfam02470 264462002598 mce related protein; Region: MCE; pfam02470 264462002599 Paraquat-inducible protein A; Region: PqiA; pfam04403 264462002600 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 264462002601 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 264462002602 tetramer interface [polypeptide binding]; other site 264462002603 heme binding pocket [chemical binding]; other site 264462002604 NADPH binding site [chemical binding]; other site 264462002605 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264462002606 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264462002607 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264462002608 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264462002609 Walker A/P-loop; other site 264462002610 ATP binding site [chemical binding]; other site 264462002611 Q-loop/lid; other site 264462002612 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 264462002613 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264462002614 ABC transporter signature motif; other site 264462002615 Walker B; other site 264462002616 D-loop; other site 264462002617 H-loop/switch region; other site 264462002618 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 264462002619 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 264462002620 dimer interface [polypeptide binding]; other site 264462002621 FMN binding site [chemical binding]; other site 264462002622 Transcriptional regulator; Region: Rrf2; pfam02082 264462002623 Rrf2 family protein; Region: rrf2_super; TIGR00738 264462002624 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264462002625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264462002626 Oligomerisation domain; Region: Oligomerisation; cl00519 264462002627 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264462002628 ligand binding site [chemical binding]; other site 264462002629 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264462002630 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264462002631 phosphopeptide binding site; other site 264462002632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462002633 salt bridge; other site 264462002634 non-specific DNA binding site [nucleotide binding]; other site 264462002635 sequence-specific DNA binding site [nucleotide binding]; other site 264462002636 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462002637 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264462002638 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 264462002639 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264462002640 P loop; other site 264462002641 GTP binding site [chemical binding]; other site 264462002642 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 264462002643 NAD binding site [chemical binding]; other site 264462002644 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264462002645 active site 264462002646 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 264462002647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264462002648 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264462002649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462002650 Cell division protein ZapA; Region: ZapA; pfam05164 264462002651 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 264462002652 phosphodiesterase; Provisional; Region: PRK12704 264462002653 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 264462002654 KH domain; Region: KH_1; pfam00013 264462002655 uncharacterized domain HDIG; Region: HDIG; TIGR00277 264462002656 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264462002657 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264462002658 active site 264462002659 HIGH motif; other site 264462002660 dimer interface [polypeptide binding]; other site 264462002661 KMSKS motif; other site 264462002662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462002663 RNA binding surface [nucleotide binding]; other site 264462002664 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264462002665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264462002666 catalytic loop [active] 264462002667 iron binding site [ion binding]; other site 264462002668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462002669 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 264462002670 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264462002671 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 264462002672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462002673 catalytic residue [active] 264462002674 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 264462002675 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 264462002676 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 264462002677 active site 264462002678 dimer interface [polypeptide binding]; other site 264462002679 effector binding site; other site 264462002680 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 264462002681 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 264462002682 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264462002683 RNA binding site [nucleotide binding]; other site 264462002684 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264462002685 RNA binding site [nucleotide binding]; other site 264462002686 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264462002687 RNA binding site [nucleotide binding]; other site 264462002688 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 264462002689 RNA binding site [nucleotide binding]; other site 264462002690 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 264462002691 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 264462002692 MPT binding site; other site 264462002693 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 264462002694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264462002695 active site 264462002696 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264462002697 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264462002698 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462002699 active site 264462002700 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264462002701 LemA family; Region: LemA; cl00742 264462002702 Repair protein; Region: Repair_PSII; pfam04536 264462002703 Repair protein; Region: Repair_PSII; cl01535 264462002704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 264462002705 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 264462002706 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 264462002707 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 264462002708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462002709 salt bridge; other site 264462002710 non-specific DNA binding site [nucleotide binding]; other site 264462002711 sequence-specific DNA binding site [nucleotide binding]; other site 264462002712 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462002713 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264462002714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264462002715 Walker A/P-loop; other site 264462002716 ATP binding site [chemical binding]; other site 264462002717 Q-loop/lid; other site 264462002718 ABC transporter signature motif; other site 264462002719 Walker B; other site 264462002720 D-loop; other site 264462002721 H-loop/switch region; other site 264462002722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264462002723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264462002724 Walker A/P-loop; other site 264462002725 ATP binding site [chemical binding]; other site 264462002726 Q-loop/lid; other site 264462002727 ABC transporter signature motif; other site 264462002728 Walker B; other site 264462002729 D-loop; other site 264462002730 H-loop/switch region; other site 264462002731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264462002732 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264462002733 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264462002734 nucleotide binding site [chemical binding]; other site 264462002735 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 264462002736 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 264462002737 active site 264462002738 Ca binding site [ion binding]; other site 264462002739 catalytic site [active] 264462002740 Aamy_C domain; Region: Aamy_C; smart00632 264462002741 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264462002742 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264462002743 Walker A/P-loop; other site 264462002744 ATP binding site [chemical binding]; other site 264462002745 Q-loop/lid; other site 264462002746 ABC transporter signature motif; other site 264462002747 Walker B; other site 264462002748 D-loop; other site 264462002749 H-loop/switch region; other site 264462002750 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264462002751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462002752 dimer interface [polypeptide binding]; other site 264462002753 conserved gate region; other site 264462002754 putative PBP binding loops; other site 264462002755 ABC-ATPase subunit interface; other site 264462002756 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 264462002757 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264462002758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462002759 dimer interface [polypeptide binding]; other site 264462002760 conserved gate region; other site 264462002761 putative PBP binding loops; other site 264462002762 ABC-ATPase subunit interface; other site 264462002763 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 264462002764 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 264462002765 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 264462002766 Ca binding site [ion binding]; other site 264462002767 active site 264462002768 catalytic site [active] 264462002769 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 264462002770 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 264462002771 trimer interface; other site 264462002772 sugar binding site [chemical binding]; other site 264462002773 Pirin-related protein [General function prediction only]; Region: COG1741 264462002774 Pirin; Region: Pirin; pfam02678 264462002775 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264462002776 AMP nucleosidase; Provisional; Region: PRK07115 264462002777 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264462002778 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264462002779 dimerization interface [polypeptide binding]; other site 264462002780 DPS ferroxidase diiron center [ion binding]; other site 264462002781 ion pore; other site 264462002782 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 264462002783 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462002784 substrate binding pocket [chemical binding]; other site 264462002785 membrane-bound complex binding site; other site 264462002786 hinge residues; other site 264462002787 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462002788 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264462002789 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 264462002790 Active site serine [active] 264462002791 RDD family; Region: RDD; pfam06271 264462002792 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 264462002793 Endonuclease I; Region: Endonuclease_1; pfam04231 264462002794 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462002795 Proline dehydrogenase; Region: Pro_dh; cl03282 264462002796 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 264462002797 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 264462002798 Glutamate binding site [chemical binding]; other site 264462002799 homodimer interface [polypeptide binding]; other site 264462002800 NAD binding site [chemical binding]; other site 264462002801 catalytic residues [active] 264462002802 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264462002803 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264462002804 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264462002805 catalytic core [active] 264462002806 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 264462002807 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 264462002808 dimerization interface [polypeptide binding]; other site 264462002809 domain crossover interface; other site 264462002810 redox-dependent activation switch; other site 264462002811 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462002812 putative active site [active] 264462002813 catalytic site [active] 264462002814 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462002815 PLD-like domain; Region: PLDc_2; pfam13091 264462002816 putative active site [active] 264462002817 catalytic site [active] 264462002818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462002819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462002820 ATP binding site [chemical binding]; other site 264462002821 Mg2+ binding site [ion binding]; other site 264462002822 G-X-G motif; other site 264462002823 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 264462002824 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 264462002825 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264462002826 isocitrate dehydrogenase; Validated; Region: PRK06451 264462002827 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 264462002828 active site 264462002829 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 264462002830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462002831 DNA binding residues [nucleotide binding] 264462002832 dimerization interface [polypeptide binding]; other site 264462002833 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264462002834 putative dimer interface [polypeptide binding]; other site 264462002835 Lipase maturation factor; Region: LMF1; pfam06762 264462002836 Predicted membrane protein [Function unknown]; Region: COG2261 264462002837 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264462002838 MutS domain III; Region: MutS_III; pfam05192 264462002839 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 264462002840 Walker A/P-loop; other site 264462002841 ATP binding site [chemical binding]; other site 264462002842 Q-loop/lid; other site 264462002843 ABC transporter signature motif; other site 264462002844 Walker B; other site 264462002845 D-loop; other site 264462002846 H-loop/switch region; other site 264462002847 Smr domain; Region: Smr; pfam01713 264462002848 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 264462002849 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 264462002850 putative active site [active] 264462002851 catalytic triad [active] 264462002852 putative dimer interface [polypeptide binding]; other site 264462002853 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 264462002854 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462002855 catalytic triad [active] 264462002856 putative active site [active] 264462002857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264462002858 binding surface 264462002859 TPR motif; other site 264462002860 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462002861 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462002862 catalytic residue [active] 264462002863 heat shock protein HtpX; Provisional; Region: PRK05457 264462002864 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 264462002865 Clp amino terminal domain; Region: Clp_N; pfam02861 264462002866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462002867 Walker A motif; other site 264462002868 ATP binding site [chemical binding]; other site 264462002869 Walker B motif; other site 264462002870 arginine finger; other site 264462002871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462002872 Walker A motif; other site 264462002873 ATP binding site [chemical binding]; other site 264462002874 Walker B motif; other site 264462002875 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264462002876 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 264462002877 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 264462002878 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 264462002879 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 264462002880 RHS Repeat; Region: RHS_repeat; cl11982 264462002881 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264462002882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264462002883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462002884 non-specific DNA binding site [nucleotide binding]; other site 264462002885 salt bridge; other site 264462002886 sequence-specific DNA binding site [nucleotide binding]; other site 264462002887 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 264462002888 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 264462002889 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264462002890 HSP70 interaction site [polypeptide binding]; other site 264462002891 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264462002892 Zn binding sites [ion binding]; other site 264462002893 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264462002894 dimer interface [polypeptide binding]; other site 264462002895 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264462002896 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 264462002897 nucleotide binding site [chemical binding]; other site 264462002898 NEF interaction site [polypeptide binding]; other site 264462002899 SBD interface [polypeptide binding]; other site 264462002900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462002901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462002902 ligand binding site [chemical binding]; other site 264462002903 flexible hinge region; other site 264462002904 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264462002905 non-specific DNA interactions [nucleotide binding]; other site 264462002906 DNA binding site [nucleotide binding] 264462002907 sequence specific DNA binding site [nucleotide binding]; other site 264462002908 putative cAMP binding site [chemical binding]; other site 264462002909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264462002910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462002911 active site residue [active] 264462002912 Predicted transporter component [General function prediction only]; Region: COG2391 264462002913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264462002914 acetyl-CoA synthetase; Provisional; Region: PRK00174 264462002915 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 264462002916 active site 264462002917 CoA binding site [chemical binding]; other site 264462002918 acyl-activating enzyme (AAE) consensus motif; other site 264462002919 AMP binding site [chemical binding]; other site 264462002920 acetate binding site [chemical binding]; other site 264462002921 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264462002922 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264462002923 FMN binding site [chemical binding]; other site 264462002924 active site 264462002925 catalytic residues [active] 264462002926 substrate binding site [chemical binding]; other site 264462002927 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 264462002928 GSH binding site [chemical binding]; other site 264462002929 catalytic residues [active] 264462002930 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462002931 Methyltransferase domain; Region: Methyltransf_11; pfam08241 264462002932 conserved hypothetical protein; Region: TIGR02285 264462002933 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 264462002934 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 264462002935 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264462002936 FMN binding site [chemical binding]; other site 264462002937 active site 264462002938 catalytic residues [active] 264462002939 substrate binding site [chemical binding]; other site 264462002940 EVE domain; Region: EVE; cl00728 264462002941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 264462002942 SEC-C motif; Region: SEC-C; pfam02810 264462002943 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 264462002944 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264462002945 putative NAD(P) binding site [chemical binding]; other site 264462002946 homodimer interface [polypeptide binding]; other site 264462002947 homotetramer interface [polypeptide binding]; other site 264462002948 active site 264462002949 fumarate hydratase; Reviewed; Region: fumC; PRK00485 264462002950 Class II fumarases; Region: Fumarase_classII; cd01362 264462002951 active site 264462002952 tetramer interface [polypeptide binding]; other site 264462002953 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264462002954 Part of AAA domain; Region: AAA_19; pfam13245 264462002955 Family description; Region: UvrD_C_2; pfam13538 264462002956 PAS domain; Region: PAS_9; pfam13426 264462002957 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462002958 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462002959 active site 264462002960 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264462002961 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462002962 P-loop; other site 264462002963 Magnesium ion binding site [ion binding]; other site 264462002964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462002965 Magnesium ion binding site [ion binding]; other site 264462002966 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 264462002967 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 264462002968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462002969 Walker A/P-loop; other site 264462002970 ATP binding site [chemical binding]; other site 264462002971 Q-loop/lid; other site 264462002972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462002973 ABC transporter signature motif; other site 264462002974 Walker B; other site 264462002975 D-loop; other site 264462002976 ABC transporter; Region: ABC_tran_2; pfam12848 264462002977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462002978 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 264462002979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462002980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462002981 ATP binding site [chemical binding]; other site 264462002982 Mg2+ binding site [ion binding]; other site 264462002983 G-X-G motif; other site 264462002984 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264462002985 HSP70 interaction site [polypeptide binding]; other site 264462002986 SWIB/MDM2 domain; Region: SWIB; pfam02201 264462002987 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264462002988 active site 264462002989 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 264462002990 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 264462002991 homotetramer interface [polypeptide binding]; other site 264462002992 ligand binding site [chemical binding]; other site 264462002993 catalytic site [active] 264462002994 NAD binding site [chemical binding]; other site 264462002995 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462002996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462002997 dimer interface [polypeptide binding]; other site 264462002998 putative CheW interface [polypeptide binding]; other site 264462002999 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264462003000 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462003001 catalytic residues [active] 264462003002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462003003 binding surface 264462003004 TPR motif; other site 264462003005 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 264462003006 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 264462003007 catalytic site [active] 264462003008 putative active site [active] 264462003009 putative substrate binding site [chemical binding]; other site 264462003010 dimer interface [polypeptide binding]; other site 264462003011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003012 active site 264462003013 phosphorylation site [posttranslational modification] 264462003014 intermolecular recognition site; other site 264462003015 dimerization interface [polypeptide binding]; other site 264462003016 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264462003017 metal-binding site [ion binding] 264462003018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462003019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462003020 substrate binding pocket [chemical binding]; other site 264462003021 membrane-bound complex binding site; other site 264462003022 hinge residues; other site 264462003023 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264462003024 putative active site pocket [active] 264462003025 dimerization interface [polypeptide binding]; other site 264462003026 putative catalytic residue [active] 264462003027 short chain dehydrogenase; Validated; Region: PRK08264 264462003028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462003029 NAD(P) binding site [chemical binding]; other site 264462003030 active site 264462003031 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264462003032 RibD C-terminal domain; Region: RibD_C; cl17279 264462003033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264462003034 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264462003035 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462003036 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462003037 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462003038 active site 264462003039 substrate binding sites [chemical binding]; other site 264462003040 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 264462003041 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 264462003042 putative arabinose transporter; Provisional; Region: PRK03545 264462003043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462003044 putative substrate translocation pore; other site 264462003045 methionine sulfoxide reductase B; Provisional; Region: PRK00222 264462003046 SelR domain; Region: SelR; pfam01641 264462003047 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 264462003048 putative hydrophobic ligand binding site [chemical binding]; other site 264462003049 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 264462003050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264462003051 ATP binding site [chemical binding]; other site 264462003052 putative Mg++ binding site [ion binding]; other site 264462003053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462003054 nucleotide binding region [chemical binding]; other site 264462003055 ATP-binding site [chemical binding]; other site 264462003056 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 264462003057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264462003058 active site 264462003059 HIGH motif; other site 264462003060 nucleotide binding site [chemical binding]; other site 264462003061 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 264462003062 KMSKS motif; other site 264462003063 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 264462003064 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 264462003065 proline dipeptidase; Provisional; Region: PRK13607 264462003066 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264462003067 active site 264462003068 SnoaL-like domain; Region: SnoaL_2; pfam12680 264462003069 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264462003070 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264462003071 ligand binding site [chemical binding]; other site 264462003072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462003073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462003074 substrate binding pocket [chemical binding]; other site 264462003075 membrane-bound complex binding site; other site 264462003076 hinge residues; other site 264462003077 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 264462003078 putative active site [active] 264462003079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462003080 TPR motif; other site 264462003081 TPR repeat; Region: TPR_11; pfam13414 264462003082 binding surface 264462003083 PAS domain S-box; Region: sensory_box; TIGR00229 264462003084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462003085 putative active site [active] 264462003086 heme pocket [chemical binding]; other site 264462003087 PAS fold; Region: PAS_4; pfam08448 264462003088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462003089 putative active site [active] 264462003090 heme pocket [chemical binding]; other site 264462003091 GAF domain; Region: GAF; pfam01590 264462003092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462003093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003094 dimer interface [polypeptide binding]; other site 264462003095 phosphorylation site [posttranslational modification] 264462003096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003097 ATP binding site [chemical binding]; other site 264462003098 Mg2+ binding site [ion binding]; other site 264462003099 G-X-G motif; other site 264462003100 Response regulator receiver domain; Region: Response_reg; pfam00072 264462003101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003102 active site 264462003103 phosphorylation site [posttranslational modification] 264462003104 intermolecular recognition site; other site 264462003105 dimerization interface [polypeptide binding]; other site 264462003106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462003107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003108 dimer interface [polypeptide binding]; other site 264462003109 phosphorylation site [posttranslational modification] 264462003110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003111 ATP binding site [chemical binding]; other site 264462003112 Mg2+ binding site [ion binding]; other site 264462003113 G-X-G motif; other site 264462003114 Response regulator receiver domain; Region: Response_reg; pfam00072 264462003115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003116 active site 264462003117 phosphorylation site [posttranslational modification] 264462003118 intermolecular recognition site; other site 264462003119 dimerization interface [polypeptide binding]; other site 264462003120 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462003121 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 264462003122 probable active site [active] 264462003123 YaeQ protein; Region: YaeQ; pfam07152 264462003124 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264462003125 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 264462003126 active site 264462003127 catalytic site [active] 264462003128 metal binding site [ion binding]; metal-binding site 264462003129 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 264462003130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264462003131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462003132 catalytic residue [active] 264462003133 DTW domain; Region: DTW; cl01221 264462003134 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 264462003135 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462003136 cleavage site 264462003137 active site 264462003138 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264462003139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264462003140 N-terminal plug; other site 264462003141 ligand-binding site [chemical binding]; other site 264462003142 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 264462003143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462003144 ATP binding site [chemical binding]; other site 264462003145 Mg++ binding site [ion binding]; other site 264462003146 motif III; other site 264462003147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462003148 nucleotide binding region [chemical binding]; other site 264462003149 ATP-binding site [chemical binding]; other site 264462003150 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 264462003151 putative RNA binding site [nucleotide binding]; other site 264462003152 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 264462003153 S1 domain; Region: S1_2; pfam13509 264462003154 S1 domain; Region: S1_2; pfam13509 264462003155 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 264462003156 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 264462003157 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264462003158 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 264462003159 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264462003160 E-class dimer interface [polypeptide binding]; other site 264462003161 P-class dimer interface [polypeptide binding]; other site 264462003162 active site 264462003163 Cu2+ binding site [ion binding]; other site 264462003164 Zn2+ binding site [ion binding]; other site 264462003165 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 264462003166 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 264462003167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462003168 Outer membrane efflux protein; Region: OEP; pfam02321 264462003169 Outer membrane efflux protein; Region: OEP; pfam02321 264462003170 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264462003171 anti sigma factor interaction site; other site 264462003172 regulatory phosphorylation site [posttranslational modification]; other site 264462003173 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 264462003174 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 264462003175 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462003176 ATP binding site [chemical binding]; other site 264462003177 Mg++ binding site [ion binding]; other site 264462003178 motif III; other site 264462003179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462003180 nucleotide binding region [chemical binding]; other site 264462003181 ATP-binding site [chemical binding]; other site 264462003182 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264462003183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462003184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462003185 Walker A/P-loop; other site 264462003186 ATP binding site [chemical binding]; other site 264462003187 Q-loop/lid; other site 264462003188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462003189 ABC transporter signature motif; other site 264462003190 Walker B; other site 264462003191 D-loop; other site 264462003192 ABC transporter; Region: ABC_tran_2; pfam12848 264462003193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462003194 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462003195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462003196 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264462003197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264462003198 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 264462003199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462003200 Walker A/P-loop; other site 264462003201 ATP binding site [chemical binding]; other site 264462003202 Q-loop/lid; other site 264462003203 ABC transporter signature motif; other site 264462003204 Walker B; other site 264462003205 D-loop; other site 264462003206 H-loop/switch region; other site 264462003207 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264462003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462003209 putative PBP binding loops; other site 264462003210 ABC-ATPase subunit interface; other site 264462003211 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264462003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462003213 dimer interface [polypeptide binding]; other site 264462003214 conserved gate region; other site 264462003215 putative PBP binding loops; other site 264462003216 ABC-ATPase subunit interface; other site 264462003217 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 264462003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462003219 putative substrate translocation pore; other site 264462003220 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 264462003221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462003222 S-adenosylmethionine binding site [chemical binding]; other site 264462003223 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462003224 active site 264462003225 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264462003226 MarR family; Region: MarR; pfam01047 264462003227 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 264462003228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462003229 Zn2+ binding site [ion binding]; other site 264462003230 Mg2+ binding site [ion binding]; other site 264462003231 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 264462003232 active site 264462003233 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462003234 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462003235 substrate binding pocket [chemical binding]; other site 264462003236 membrane-bound complex binding site; other site 264462003237 hinge residues; other site 264462003238 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 264462003239 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 264462003240 Catalytic site; other site 264462003241 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 264462003242 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462003243 catalytic triad [active] 264462003244 putative active site [active] 264462003245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264462003246 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264462003247 metal binding site [ion binding]; metal-binding site 264462003248 active site 264462003249 I-site; other site 264462003250 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 264462003251 [2Fe-2S] cluster binding site [ion binding]; other site 264462003252 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264462003253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462003254 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 264462003255 Predicted membrane protein [Function unknown]; Region: COG2855 264462003256 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 264462003257 putative active site [active] 264462003258 catalytic triad [active] 264462003259 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 264462003260 PA/protease or protease-like domain interface [polypeptide binding]; other site 264462003261 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 264462003262 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 264462003263 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462003264 Interdomain contacts; other site 264462003265 Cytokine receptor motif; other site 264462003266 Calx-beta domain; Region: Calx-beta; cl02522 264462003267 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462003268 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003269 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462003270 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003271 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462003272 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003273 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003274 MarR family; Region: MarR_2; pfam12802 264462003275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264462003276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264462003277 Coenzyme A binding pocket [chemical binding]; other site 264462003278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264462003279 CoenzymeA binding site [chemical binding]; other site 264462003280 subunit interaction site [polypeptide binding]; other site 264462003281 PHB binding site; other site 264462003282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462003283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462003284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462003285 dimerization interface [polypeptide binding]; other site 264462003286 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 264462003287 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264462003288 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 264462003289 substrate binding pocket [chemical binding]; other site 264462003290 active site 264462003291 iron coordination sites [ion binding]; other site 264462003292 hypothetical protein; Provisional; Region: PRK07190 264462003293 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264462003294 ASCH domain; Region: ASCH; pfam04266 264462003295 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 264462003296 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264462003297 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264462003298 GDP-binding site [chemical binding]; other site 264462003299 ACT binding site; other site 264462003300 IMP binding site; other site 264462003301 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264462003302 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 264462003303 putative ligand binding site [chemical binding]; other site 264462003304 NAD binding site [chemical binding]; other site 264462003305 dimerization interface [polypeptide binding]; other site 264462003306 catalytic site [active] 264462003307 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 264462003308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462003309 catalytic residue [active] 264462003310 Lipopolysaccharide-assembly; Region: LptE; cl01125 264462003311 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264462003312 DNA polymerase III, delta subunit; Region: holA; TIGR01128 264462003313 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264462003314 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264462003315 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264462003316 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462003317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462003318 dimer interface [polypeptide binding]; other site 264462003319 putative CheW interface [polypeptide binding]; other site 264462003320 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462003321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462003322 dimer interface [polypeptide binding]; other site 264462003323 putative CheW interface [polypeptide binding]; other site 264462003324 Translocation protein Sec62; Region: Sec62; cl02170 264462003325 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 264462003326 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462003327 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264462003328 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462003329 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462003330 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264462003331 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462003332 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462003333 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264462003334 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264462003335 PilZ domain; Region: PilZ; pfam07238 264462003336 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 264462003337 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 264462003338 homodimer interface [polypeptide binding]; other site 264462003339 metal binding site [ion binding]; metal-binding site 264462003340 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 264462003341 homodimer interface [polypeptide binding]; other site 264462003342 active site 264462003343 putative chemical substrate binding site [chemical binding]; other site 264462003344 metal binding site [ion binding]; metal-binding site 264462003345 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 264462003346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462003347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462003348 Zn2+ binding site [ion binding]; other site 264462003349 Mg2+ binding site [ion binding]; other site 264462003350 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 264462003351 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264462003352 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 264462003353 RF-1 domain; Region: RF-1; pfam00472 264462003354 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264462003355 FtsX-like permease family; Region: FtsX; pfam02687 264462003356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462003357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462003358 Walker A/P-loop; other site 264462003359 ATP binding site [chemical binding]; other site 264462003360 Q-loop/lid; other site 264462003361 ABC transporter signature motif; other site 264462003362 Walker B; other site 264462003363 D-loop; other site 264462003364 H-loop/switch region; other site 264462003365 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264462003366 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462003367 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462003368 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462003369 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462003370 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462003371 Surface antigen; Region: Bac_surface_Ag; pfam01103 264462003372 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264462003373 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264462003374 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264462003375 active site 264462003376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 264462003377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 264462003378 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264462003379 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 264462003380 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 264462003381 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 264462003382 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264462003383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264462003384 putative acyl-acceptor binding pocket; other site 264462003385 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 264462003386 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462003387 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462003388 ligand binding site [chemical binding]; other site 264462003389 flexible hinge region; other site 264462003390 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462003391 ligand binding site [chemical binding]; other site 264462003392 flexible hinge region; other site 264462003393 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462003394 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462003395 putative active site [active] 264462003396 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462003397 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264462003398 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462003399 putative active site [active] 264462003400 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462003401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003402 active site 264462003403 phosphorylation site [posttranslational modification] 264462003404 intermolecular recognition site; other site 264462003405 dimerization interface [polypeptide binding]; other site 264462003406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462003407 Walker A motif; other site 264462003408 ATP binding site [chemical binding]; other site 264462003409 Walker B motif; other site 264462003410 arginine finger; other site 264462003411 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264462003412 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 264462003413 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 264462003414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264462003415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003416 dimer interface [polypeptide binding]; other site 264462003417 phosphorylation site [posttranslational modification] 264462003418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003419 ATP binding site [chemical binding]; other site 264462003420 Mg2+ binding site [ion binding]; other site 264462003421 G-X-G motif; other site 264462003422 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264462003423 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264462003424 active site 264462003425 Riboflavin kinase; Region: Flavokinase; pfam01687 264462003426 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 264462003427 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 264462003428 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264462003429 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264462003430 Walker A motif; other site 264462003431 ATP binding site [chemical binding]; other site 264462003432 Walker B motif; other site 264462003433 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 264462003434 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264462003435 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264462003436 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462003437 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462003438 PAS domain; Region: PAS; smart00091 264462003439 putative active site [active] 264462003440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003441 phosphorylation site [posttranslational modification] 264462003442 dimer interface [polypeptide binding]; other site 264462003443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003444 ATP binding site [chemical binding]; other site 264462003445 Mg2+ binding site [ion binding]; other site 264462003446 G-X-G motif; other site 264462003447 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462003448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003449 active site 264462003450 phosphorylation site [posttranslational modification] 264462003451 intermolecular recognition site; other site 264462003452 dimerization interface [polypeptide binding]; other site 264462003453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462003454 Walker A motif; other site 264462003455 ATP binding site [chemical binding]; other site 264462003456 Walker B motif; other site 264462003457 arginine finger; other site 264462003458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462003459 Ferritin-like domain; Region: Ferritin; pfam00210 264462003460 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264462003461 dinuclear metal binding motif [ion binding]; other site 264462003462 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462003463 putative active site [active] 264462003464 catalytic site [active] 264462003465 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462003466 PLD-like domain; Region: PLDc_2; pfam13091 264462003467 putative active site [active] 264462003468 catalytic site [active] 264462003469 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 264462003470 Zn binding site [ion binding]; other site 264462003471 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462003472 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 264462003473 probable active site [active] 264462003474 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264462003475 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264462003476 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 264462003477 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264462003478 potential catalytic triad [active] 264462003479 conserved cys residue [active] 264462003480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462003481 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264462003482 Walker A motif; other site 264462003483 ATP binding site [chemical binding]; other site 264462003484 Walker B motif; other site 264462003485 arginine finger; other site 264462003486 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264462003487 exopolyphosphatase; Region: exo_poly_only; TIGR03706 264462003488 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 264462003489 Protein required for attachment to host cells; Region: Host_attach; pfam10116 264462003490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462003491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462003492 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 264462003493 Walker A/P-loop; other site 264462003494 ATP binding site [chemical binding]; other site 264462003495 Q-loop/lid; other site 264462003496 ABC transporter signature motif; other site 264462003497 Walker B; other site 264462003498 D-loop; other site 264462003499 H-loop/switch region; other site 264462003500 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 264462003501 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 264462003502 ATP-binding site [chemical binding]; other site 264462003503 Sugar specificity; other site 264462003504 Pyrimidine base specificity; other site 264462003505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462003506 active site 264462003507 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 264462003508 hypothetical protein; Validated; Region: PRK07198 264462003509 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 264462003510 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 264462003511 dimerization interface [polypeptide binding]; other site 264462003512 active site 264462003513 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264462003514 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264462003515 tetrameric interface [polypeptide binding]; other site 264462003516 NAD binding site [chemical binding]; other site 264462003517 catalytic residues [active] 264462003518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462003519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462003520 putative active site [active] 264462003521 heme pocket [chemical binding]; other site 264462003522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003523 dimer interface [polypeptide binding]; other site 264462003524 phosphorylation site [posttranslational modification] 264462003525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003526 ATP binding site [chemical binding]; other site 264462003527 Mg2+ binding site [ion binding]; other site 264462003528 G-X-G motif; other site 264462003529 Response regulator receiver domain; Region: Response_reg; pfam00072 264462003530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462003531 active site 264462003532 phosphorylation site [posttranslational modification] 264462003533 intermolecular recognition site; other site 264462003534 dimerization interface [polypeptide binding]; other site 264462003535 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462003536 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462003537 active site 264462003538 substrate binding sites [chemical binding]; other site 264462003539 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 264462003540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264462003541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264462003542 Coenzyme A binding pocket [chemical binding]; other site 264462003543 ribosome maturation protein RimP; Reviewed; Region: PRK00092 264462003544 Sm and related proteins; Region: Sm_like; cl00259 264462003545 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 264462003546 putative oligomer interface [polypeptide binding]; other site 264462003547 putative RNA binding site [nucleotide binding]; other site 264462003548 NusA N-terminal domain; Region: NusA_N; pfam08529 264462003549 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 264462003550 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264462003551 RNA binding site [nucleotide binding]; other site 264462003552 homodimer interface [polypeptide binding]; other site 264462003553 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264462003554 G-X-X-G motif; other site 264462003555 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264462003556 G-X-X-G motif; other site 264462003557 translation initiation factor IF-2; Region: IF-2; TIGR00487 264462003558 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264462003559 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264462003560 G1 box; other site 264462003561 putative GEF interaction site [polypeptide binding]; other site 264462003562 GTP/Mg2+ binding site [chemical binding]; other site 264462003563 Switch I region; other site 264462003564 G2 box; other site 264462003565 G3 box; other site 264462003566 Switch II region; other site 264462003567 G4 box; other site 264462003568 G5 box; other site 264462003569 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264462003570 Translation-initiation factor 2; Region: IF-2; pfam11987 264462003571 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264462003572 Ribosome-binding factor A; Region: RBFA; pfam02033 264462003573 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 264462003574 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264462003575 RNA binding site [nucleotide binding]; other site 264462003576 active site 264462003577 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264462003578 16S/18S rRNA binding site [nucleotide binding]; other site 264462003579 S13e-L30e interaction site [polypeptide binding]; other site 264462003580 25S rRNA binding site [nucleotide binding]; other site 264462003581 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264462003582 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264462003583 RNase E interface [polypeptide binding]; other site 264462003584 trimer interface [polypeptide binding]; other site 264462003585 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264462003586 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264462003587 RNase E interface [polypeptide binding]; other site 264462003588 trimer interface [polypeptide binding]; other site 264462003589 active site 264462003590 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264462003591 putative nucleic acid binding region [nucleotide binding]; other site 264462003592 G-X-X-G motif; other site 264462003593 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264462003594 RNA binding site [nucleotide binding]; other site 264462003595 domain interface; other site 264462003596 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264462003597 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264462003598 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264462003599 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264462003600 trimer interface [polypeptide binding]; other site 264462003601 active site 264462003602 Yip1 domain; Region: Yip1; pfam04893 264462003603 Family of unknown function (DUF490); Region: DUF490; pfam04357 264462003604 Surface antigen; Region: Bac_surface_Ag; pfam01103 264462003605 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462003606 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 264462003607 Ligand binding site; other site 264462003608 Putative Catalytic site; other site 264462003609 DXD motif; other site 264462003610 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 264462003611 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264462003612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003613 ATP binding site [chemical binding]; other site 264462003614 Mg2+ binding site [ion binding]; other site 264462003615 G-X-G motif; other site 264462003616 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 264462003617 ATP binding site [chemical binding]; other site 264462003618 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 264462003619 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264462003620 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264462003621 hypothetical protein; Provisional; Region: PRK11820 264462003622 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264462003623 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264462003624 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264462003625 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264462003626 catalytic site [active] 264462003627 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 264462003628 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264462003629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462003630 Zn2+ binding site [ion binding]; other site 264462003631 Mg2+ binding site [ion binding]; other site 264462003632 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264462003633 synthetase active site [active] 264462003634 NTP binding site [chemical binding]; other site 264462003635 metal binding site [ion binding]; metal-binding site 264462003636 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264462003637 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264462003638 CHASE domain; Region: CHASE; cl01369 264462003639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462003640 PAS domain; Region: PAS_9; pfam13426 264462003641 putative active site [active] 264462003642 heme pocket [chemical binding]; other site 264462003643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003644 dimer interface [polypeptide binding]; other site 264462003645 phosphorylation site [posttranslational modification] 264462003646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003647 ATP binding site [chemical binding]; other site 264462003648 Mg2+ binding site [ion binding]; other site 264462003649 G-X-G motif; other site 264462003650 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264462003651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264462003652 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 264462003653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264462003654 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 264462003655 IucA / IucC family; Region: IucA_IucC; pfam04183 264462003656 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264462003657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 264462003658 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 264462003659 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 264462003660 IucA / IucC family; Region: IucA_IucC; pfam04183 264462003661 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264462003662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264462003663 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264462003664 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 264462003665 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264462003666 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264462003667 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264462003668 dimer interface [polypeptide binding]; other site 264462003669 ssDNA binding site [nucleotide binding]; other site 264462003670 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264462003671 Competence protein A; Region: Competence_A; pfam11104 264462003672 Cell division protein FtsA; Region: FtsA; cl17206 264462003673 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 264462003674 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 264462003675 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264462003676 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264462003677 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264462003678 type II secretion system protein F; Region: GspF; TIGR02120 264462003679 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462003680 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264462003681 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264462003682 type II secretion system protein E; Region: type_II_gspE; TIGR02533 264462003683 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264462003684 Walker A motif; other site 264462003685 ATP binding site [chemical binding]; other site 264462003686 Walker B motif; other site 264462003687 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264462003688 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264462003689 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264462003690 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264462003691 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264462003692 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 264462003693 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462003694 protein binding site [polypeptide binding]; other site 264462003695 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 264462003696 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 264462003697 ResB-like family; Region: ResB; pfam05140 264462003698 ResB-like family; Region: ResB; pfam05140 264462003699 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 264462003700 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 264462003701 heme-binding residues [chemical binding]; other site 264462003702 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264462003703 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 264462003704 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 264462003705 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264462003706 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 264462003707 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 264462003708 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 264462003709 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264462003710 PilZ domain; Region: PilZ; pfam07238 264462003711 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264462003712 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264462003713 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264462003714 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264462003715 active site 264462003716 dimer interface [polypeptide binding]; other site 264462003717 motif 1; other site 264462003718 motif 2; other site 264462003719 motif 3; other site 264462003720 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264462003721 anticodon binding site; other site 264462003722 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 264462003723 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264462003724 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264462003725 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264462003726 putative active site [active] 264462003727 dimerization interface [polypeptide binding]; other site 264462003728 putative tRNAtyr binding site [nucleotide binding]; other site 264462003729 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 264462003730 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 264462003731 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 264462003732 Putative esterase; Region: Esterase; pfam00756 264462003733 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 264462003734 heterodimerization interface [polypeptide binding]; other site 264462003735 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 264462003736 heterodimerization interface [polypeptide binding]; other site 264462003737 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003738 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462003739 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003740 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462003741 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462003742 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462003743 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003744 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003745 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462003746 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264462003747 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264462003748 23S rRNA binding site [nucleotide binding]; other site 264462003749 L21 binding site [polypeptide binding]; other site 264462003750 L13 binding site [polypeptide binding]; other site 264462003751 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 264462003752 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 264462003753 homotetramer interface [polypeptide binding]; other site 264462003754 FMN binding site [chemical binding]; other site 264462003755 homodimer contacts [polypeptide binding]; other site 264462003756 putative active site [active] 264462003757 putative substrate binding site [chemical binding]; other site 264462003758 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 264462003759 homodimer interface [polypeptide binding]; other site 264462003760 catalytic residues [active] 264462003761 NAD binding site [chemical binding]; other site 264462003762 substrate binding pocket [chemical binding]; other site 264462003763 flexible flap; other site 264462003764 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 264462003765 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 264462003766 diphosphomevalonate decarboxylase; Region: PLN02407 264462003767 mevalonate kinase; Region: mevalon_kin; TIGR00549 264462003768 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264462003769 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 264462003770 A new structural DNA glycosylase; Region: AlkD_like; cd06561 264462003771 active site 264462003772 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264462003773 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264462003774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462003775 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 264462003776 DNA binding site [nucleotide binding] 264462003777 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264462003778 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 264462003779 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264462003780 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264462003781 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264462003782 dimer interface [polypeptide binding]; other site 264462003783 motif 1; other site 264462003784 active site 264462003785 motif 2; other site 264462003786 motif 3; other site 264462003787 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264462003788 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264462003789 putative tRNA-binding site [nucleotide binding]; other site 264462003790 B3/4 domain; Region: B3_4; pfam03483 264462003791 tRNA synthetase B5 domain; Region: B5; smart00874 264462003792 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264462003793 dimer interface [polypeptide binding]; other site 264462003794 motif 1; other site 264462003795 motif 3; other site 264462003796 motif 2; other site 264462003797 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 264462003798 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264462003799 IHF dimer interface [polypeptide binding]; other site 264462003800 IHF - DNA interface [nucleotide binding]; other site 264462003801 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 264462003802 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264462003803 DNA binding residues [nucleotide binding] 264462003804 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462003805 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 264462003806 dimerization interface [polypeptide binding]; other site 264462003807 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264462003808 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264462003809 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 264462003810 active site 264462003811 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 264462003812 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264462003813 catalytic core [active] 264462003814 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 264462003815 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264462003816 metal binding site 2 [ion binding]; metal-binding site 264462003817 putative DNA binding helix; other site 264462003818 metal binding site 1 [ion binding]; metal-binding site 264462003819 dimer interface [polypeptide binding]; other site 264462003820 structural Zn2+ binding site [ion binding]; other site 264462003821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462003822 PAS fold; Region: PAS_3; pfam08447 264462003823 putative active site [active] 264462003824 heme pocket [chemical binding]; other site 264462003825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462003826 dimer interface [polypeptide binding]; other site 264462003827 phosphorylation site [posttranslational modification] 264462003828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462003829 ATP binding site [chemical binding]; other site 264462003830 Mg2+ binding site [ion binding]; other site 264462003831 G-X-G motif; other site 264462003832 PBP superfamily domain; Region: PBP_like_2; cl17296 264462003833 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 264462003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462003835 dimer interface [polypeptide binding]; other site 264462003836 conserved gate region; other site 264462003837 putative PBP binding loops; other site 264462003838 ABC-ATPase subunit interface; other site 264462003839 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 264462003840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462003841 dimer interface [polypeptide binding]; other site 264462003842 conserved gate region; other site 264462003843 putative PBP binding loops; other site 264462003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264462003845 ABC-ATPase subunit interface; other site 264462003846 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 264462003847 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264462003848 Walker A/P-loop; other site 264462003849 ATP binding site [chemical binding]; other site 264462003850 Q-loop/lid; other site 264462003851 ABC transporter signature motif; other site 264462003852 Walker B; other site 264462003853 D-loop; other site 264462003854 H-loop/switch region; other site 264462003855 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264462003856 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 264462003857 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 264462003858 NAD binding site [chemical binding]; other site 264462003859 homotetramer interface [polypeptide binding]; other site 264462003860 homodimer interface [polypeptide binding]; other site 264462003861 substrate binding site [chemical binding]; other site 264462003862 active site 264462003863 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264462003864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462003865 ATP binding site [chemical binding]; other site 264462003866 putative Mg++ binding site [ion binding]; other site 264462003867 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 264462003868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462003869 nucleotide binding region [chemical binding]; other site 264462003870 ATP-binding site [chemical binding]; other site 264462003871 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 264462003872 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264462003873 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264462003874 Sulfatase; Region: Sulfatase; cl17466 264462003875 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 264462003876 Sulfatase; Region: Sulfatase; cl17466 264462003877 O-Antigen ligase; Region: Wzy_C; pfam04932 264462003878 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 264462003879 Sulfatase; Region: Sulfatase; cl17466 264462003880 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 264462003881 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264462003882 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 264462003883 NAD binding site [chemical binding]; other site 264462003884 substrate binding site [chemical binding]; other site 264462003885 active site 264462003886 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 264462003887 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264462003888 inhibitor-cofactor binding pocket; inhibition site 264462003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462003890 catalytic residue [active] 264462003891 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 264462003892 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264462003893 active site 264462003894 homodimer interface [polypeptide binding]; other site 264462003895 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 264462003896 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 264462003897 putative active site [active] 264462003898 putative substrate binding site [chemical binding]; other site 264462003899 putative cosubstrate binding site; other site 264462003900 catalytic site [active] 264462003901 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 264462003902 active site 264462003903 hexamer interface [polypeptide binding]; other site 264462003904 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 264462003905 NeuB family; Region: NeuB; pfam03102 264462003906 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 264462003907 NeuB binding interface [polypeptide binding]; other site 264462003908 putative substrate binding site [chemical binding]; other site 264462003909 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264462003910 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264462003911 putative trimer interface [polypeptide binding]; other site 264462003912 putative CoA binding site [chemical binding]; other site 264462003913 FOG: CBS domain [General function prediction only]; Region: COG0517 264462003914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 264462003915 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264462003916 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 264462003917 Substrate binding site; other site 264462003918 metal-binding site 264462003919 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 264462003920 ligand binding site; other site 264462003921 tetramer interface; other site 264462003922 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264462003923 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 264462003924 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 264462003925 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 264462003926 Ligand Binding Site [chemical binding]; other site 264462003927 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 264462003928 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264462003929 putative active site [active] 264462003930 oxyanion strand; other site 264462003931 catalytic triad [active] 264462003932 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 264462003933 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264462003934 substrate binding site [chemical binding]; other site 264462003935 glutamase interaction surface [polypeptide binding]; other site 264462003936 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 264462003937 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264462003938 NAD(P) binding site [chemical binding]; other site 264462003939 homodimer interface [polypeptide binding]; other site 264462003940 substrate binding site [chemical binding]; other site 264462003941 active site 264462003942 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 264462003943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462003944 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264462003945 NAD(P) binding site [chemical binding]; other site 264462003946 active site 264462003947 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 264462003948 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 264462003949 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264462003950 active site 264462003951 homodimer interface [polypeptide binding]; other site 264462003952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264462003953 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 264462003954 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264462003955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462003956 NAD(P) binding site [chemical binding]; other site 264462003957 active site 264462003958 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264462003959 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264462003960 putative trimer interface [polypeptide binding]; other site 264462003961 putative CoA binding site [chemical binding]; other site 264462003962 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264462003963 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264462003964 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264462003965 NAD(P) binding site [chemical binding]; other site 264462003966 homodimer interface [polypeptide binding]; other site 264462003967 substrate binding site [chemical binding]; other site 264462003968 active site 264462003969 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462003971 S-adenosylmethionine binding site [chemical binding]; other site 264462003972 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 264462003973 active site 264462003974 catalytic site [active] 264462003975 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264462003976 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264462003977 FMN binding site [chemical binding]; other site 264462003978 substrate binding site [chemical binding]; other site 264462003979 putative catalytic residue [active] 264462003980 mobile mystery protein A; Region: mob_myst_A; TIGR02612 264462003981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462003982 non-specific DNA binding site [nucleotide binding]; other site 264462003983 salt bridge; other site 264462003984 sequence-specific DNA binding site [nucleotide binding]; other site 264462003985 mobile mystery protein B; Region: mob_myst_B; TIGR02613 264462003986 Fic/DOC family; Region: Fic; pfam02661 264462003987 Fic/DOC family; Region: Fic; cl00960 264462003988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 264462003989 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264462003990 trimer interface [polypeptide binding]; other site 264462003991 putative Zn binding site [ion binding]; other site 264462003992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264462003993 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264462003994 dimer interface [polypeptide binding]; other site 264462003995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462003996 catalytic residue [active] 264462003997 hypothetical protein; Provisional; Region: PRK05421 264462003998 putative catalytic site [active] 264462003999 putative phosphate binding site [ion binding]; other site 264462004000 putative metal binding site [ion binding]; other site 264462004001 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462004002 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha; Region: DD_cGKI-alpha; cd12085 264462004003 homodimer interface [polypeptide binding]; other site 264462004004 putative GKAP docking site [polypeptide binding]; other site 264462004005 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264462004006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462004007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462004008 DNA binding residues [nucleotide binding] 264462004009 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 264462004010 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 264462004011 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264462004012 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 264462004013 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 264462004014 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 264462004015 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 264462004016 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 264462004017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462004018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264462004019 dimerization interface [polypeptide binding]; other site 264462004020 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 264462004021 substrate binding pocket [chemical binding]; other site 264462004022 substrate-Mg2+ binding site; other site 264462004023 aspartate-rich region 1; other site 264462004024 aspartate-rich region 2; other site 264462004025 phytoene desaturase; Region: crtI_fam; TIGR02734 264462004026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462004027 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264462004028 catalytic residues [active] 264462004029 substrate binding pocket [chemical binding]; other site 264462004030 substrate-Mg2+ binding site; other site 264462004031 aspartate-rich region 1; other site 264462004032 aspartate-rich region 2; other site 264462004033 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264462004034 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264462004035 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264462004036 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264462004037 Walker A/P-loop; other site 264462004038 ATP binding site [chemical binding]; other site 264462004039 Q-loop/lid; other site 264462004040 ABC transporter signature motif; other site 264462004041 Walker B; other site 264462004042 D-loop; other site 264462004043 H-loop/switch region; other site 264462004044 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264462004045 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 264462004046 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 264462004047 lycopene cyclase; Region: lycopene_cycl; TIGR01789 264462004048 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264462004049 homodimer interaction site [polypeptide binding]; other site 264462004050 cofactor binding site; other site 264462004051 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264462004052 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264462004053 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264462004054 active site 264462004055 HIGH motif; other site 264462004056 KMSKS motif; other site 264462004057 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264462004058 tRNA binding surface [nucleotide binding]; other site 264462004059 anticodon binding site; other site 264462004060 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264462004061 dimer interface [polypeptide binding]; other site 264462004062 putative tRNA-binding site [nucleotide binding]; other site 264462004063 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 264462004064 active site clefts [active] 264462004065 zinc binding site [ion binding]; other site 264462004066 dimer interface [polypeptide binding]; other site 264462004067 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 264462004068 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 264462004069 homodimer interface [polypeptide binding]; other site 264462004070 substrate-cofactor binding pocket; other site 264462004071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462004072 catalytic residue [active] 264462004073 rod shape-determining protein MreB; Provisional; Region: PRK13930 264462004074 MreB and similar proteins; Region: MreB_like; cd10225 264462004075 nucleotide binding site [chemical binding]; other site 264462004076 Mg binding site [ion binding]; other site 264462004077 putative protofilament interaction site [polypeptide binding]; other site 264462004078 RodZ interaction site [polypeptide binding]; other site 264462004079 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 264462004080 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264462004081 putative metal binding site; other site 264462004082 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462004083 active site residue [active] 264462004084 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264462004085 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264462004086 dimer interface [polypeptide binding]; other site 264462004087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462004088 catalytic residue [active] 264462004089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462004090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462004091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462004092 dimerization interface [polypeptide binding]; other site 264462004093 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264462004094 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462004095 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 264462004096 Predicted flavoprotein [General function prediction only]; Region: COG0431 264462004097 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264462004098 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 264462004099 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 264462004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462004101 dimer interface [polypeptide binding]; other site 264462004102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004103 ATP binding site [chemical binding]; other site 264462004104 Mg2+ binding site [ion binding]; other site 264462004105 G-X-G motif; other site 264462004106 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 264462004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462004108 active site 264462004109 phosphorylation site [posttranslational modification] 264462004110 intermolecular recognition site; other site 264462004111 dimerization interface [polypeptide binding]; other site 264462004112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462004113 DNA binding site [nucleotide binding] 264462004114 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462004115 Zn2+ binding site [ion binding]; other site 264462004116 Mg2+ binding site [ion binding]; other site 264462004117 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462004118 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264462004119 homotrimer interaction site [polypeptide binding]; other site 264462004120 putative active site [active] 264462004121 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264462004122 putative active site [active] 264462004123 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264462004124 Permease; Region: Permease; pfam02405 264462004125 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264462004126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462004127 Walker A/P-loop; other site 264462004128 ATP binding site [chemical binding]; other site 264462004129 Q-loop/lid; other site 264462004130 ABC transporter signature motif; other site 264462004131 Walker B; other site 264462004132 D-loop; other site 264462004133 H-loop/switch region; other site 264462004134 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 264462004135 mce related protein; Region: MCE; pfam02470 264462004136 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264462004137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004138 substrate binding pocket [chemical binding]; other site 264462004139 membrane-bound complex binding site; other site 264462004140 hinge residues; other site 264462004141 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462004142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004143 substrate binding pocket [chemical binding]; other site 264462004144 membrane-bound complex binding site; other site 264462004145 hinge residues; other site 264462004146 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264462004147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462004148 FtsX-like permease family; Region: FtsX; pfam02687 264462004149 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 264462004150 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 264462004151 trimer interface [polypeptide binding]; other site 264462004152 active site 264462004153 substrate binding site [chemical binding]; other site 264462004154 CoA binding site [chemical binding]; other site 264462004155 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 264462004156 putative active site [active] 264462004157 Zn binding site [ion binding]; other site 264462004158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264462004159 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264462004160 active site 264462004161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264462004162 substrate binding site [chemical binding]; other site 264462004163 catalytic residues [active] 264462004164 dimer interface [polypeptide binding]; other site 264462004165 glutamate racemase; Provisional; Region: PRK00865 264462004166 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 264462004167 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264462004168 active site 264462004169 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264462004170 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 264462004171 NADP binding site [chemical binding]; other site 264462004172 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 264462004173 putative hydrophobic ligand binding site [chemical binding]; other site 264462004174 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264462004175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004176 membrane-bound complex binding site; other site 264462004177 hinge residues; other site 264462004178 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264462004179 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 264462004180 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462004181 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462004182 active site 264462004183 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 264462004184 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264462004185 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462004186 hypothetical protein; Validated; Region: PRK00029 264462004187 Uncharacterized conserved protein [Function unknown]; Region: COG0397 264462004188 MerC mercury resistance protein; Region: MerC; pfam03203 264462004189 High potential iron-sulfur protein; Region: HIPIP; pfam01355 264462004190 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 264462004191 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264462004192 acyl-activating enzyme (AAE) consensus motif; other site 264462004193 putative AMP binding site [chemical binding]; other site 264462004194 putative active site [active] 264462004195 putative CoA binding site [chemical binding]; other site 264462004196 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264462004197 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264462004198 catalytic triad [active] 264462004199 heat shock protein 90; Provisional; Region: PRK05218 264462004200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004201 ATP binding site [chemical binding]; other site 264462004202 Mg2+ binding site [ion binding]; other site 264462004203 G-X-G motif; other site 264462004204 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264462004205 active site 264462004206 dimer interface [polypeptide binding]; other site 264462004207 motif 1; other site 264462004208 motif 2; other site 264462004209 motif 3; other site 264462004210 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 264462004211 anticodon binding site; other site 264462004212 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264462004213 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 264462004214 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 264462004215 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 264462004216 tetramer interface [polypeptide binding]; other site 264462004217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462004218 catalytic residue [active] 264462004219 agmatinase; Region: agmatinase; TIGR01230 264462004220 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 264462004221 putative active site [active] 264462004222 putative metal binding site [ion binding]; other site 264462004223 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 264462004224 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264462004225 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 264462004226 putative ion selectivity filter; other site 264462004227 putative pore gating glutamate residue; other site 264462004228 putative H+/Cl- coupling transport residue; other site 264462004229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462004230 Zn2+ binding site [ion binding]; other site 264462004231 Mg2+ binding site [ion binding]; other site 264462004232 epoxyqueuosine reductase; Region: TIGR00276 264462004233 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264462004234 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 264462004235 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264462004236 active site 264462004237 NTP binding site [chemical binding]; other site 264462004238 metal binding triad [ion binding]; metal-binding site 264462004239 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264462004240 RDD family; Region: RDD; pfam06271 264462004241 HD domain; Region: HD_5; pfam13487 264462004242 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 264462004243 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 264462004244 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264462004245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462004246 active site 264462004247 phosphorylation site [posttranslational modification] 264462004248 intermolecular recognition site; other site 264462004249 dimerization interface [polypeptide binding]; other site 264462004250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462004251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264462004252 DNA binding residues [nucleotide binding] 264462004253 dimerization interface [polypeptide binding]; other site 264462004254 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264462004255 PAS fold; Region: PAS_4; pfam08448 264462004256 PAS domain; Region: PAS_9; pfam13426 264462004257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462004258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462004259 dimer interface [polypeptide binding]; other site 264462004260 phosphorylation site [posttranslational modification] 264462004261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004262 ATP binding site [chemical binding]; other site 264462004263 Mg2+ binding site [ion binding]; other site 264462004264 G-X-G motif; other site 264462004265 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462004266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462004267 active site 264462004268 phosphorylation site [posttranslational modification] 264462004269 intermolecular recognition site; other site 264462004270 dimerization interface [polypeptide binding]; other site 264462004271 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264462004272 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264462004273 HflX GTPase family; Region: HflX; cd01878 264462004274 G1 box; other site 264462004275 GTP/Mg2+ binding site [chemical binding]; other site 264462004276 Switch I region; other site 264462004277 G2 box; other site 264462004278 G3 box; other site 264462004279 Switch II region; other site 264462004280 G4 box; other site 264462004281 G5 box; other site 264462004282 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 264462004283 Chromate transporter; Region: Chromate_transp; pfam02417 264462004284 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 264462004285 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264462004286 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264462004287 putative NAD(P) binding site [chemical binding]; other site 264462004288 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264462004289 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264462004290 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264462004291 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 264462004292 dimer interface [polypeptide binding]; other site 264462004293 active site 264462004294 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 264462004295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264462004296 substrate binding site [chemical binding]; other site 264462004297 oxyanion hole (OAH) forming residues; other site 264462004298 trimer interface [polypeptide binding]; other site 264462004299 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264462004300 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264462004301 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264462004302 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264462004303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264462004304 Coenzyme A binding pocket [chemical binding]; other site 264462004305 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 264462004306 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 264462004307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462004308 putative substrate translocation pore; other site 264462004309 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 264462004310 active site 264462004311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264462004312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264462004313 putative acyl-acceptor binding pocket; other site 264462004314 Bacterial SH3 domain; Region: SH3_3; cl17532 264462004315 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264462004316 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264462004317 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264462004318 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 264462004319 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264462004320 substrate binding site [chemical binding]; other site 264462004321 oxyanion hole (OAH) forming residues; other site 264462004322 trimer interface [polypeptide binding]; other site 264462004323 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 264462004324 B12 binding site [chemical binding]; other site 264462004325 cobalt ligand [ion binding]; other site 264462004326 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264462004327 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 264462004328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462004329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462004330 dimerization interface [polypeptide binding]; other site 264462004331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462004332 dimer interface [polypeptide binding]; other site 264462004333 phosphorylation site [posttranslational modification] 264462004334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004335 ATP binding site [chemical binding]; other site 264462004336 Mg2+ binding site [ion binding]; other site 264462004337 G-X-G motif; other site 264462004338 Predicted membrane protein [Function unknown]; Region: COG2261 264462004339 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264462004340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264462004341 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 264462004342 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 264462004343 active site 264462004344 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 264462004345 FeoA domain; Region: FeoA; pfam04023 264462004346 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264462004347 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264462004348 G1 box; other site 264462004349 GTP/Mg2+ binding site [chemical binding]; other site 264462004350 Switch I region; other site 264462004351 G2 box; other site 264462004352 G3 box; other site 264462004353 Switch II region; other site 264462004354 G4 box; other site 264462004355 G5 box; other site 264462004356 Nucleoside recognition; Region: Gate; pfam07670 264462004357 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264462004358 Nucleoside recognition; Region: Gate; pfam07670 264462004359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264462004360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264462004361 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264462004362 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264462004363 NAD binding site [chemical binding]; other site 264462004364 substrate binding site [chemical binding]; other site 264462004365 homodimer interface [polypeptide binding]; other site 264462004366 active site 264462004367 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264462004368 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264462004369 substrate binding site; other site 264462004370 tetramer interface; other site 264462004371 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264462004372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264462004373 inhibitor-cofactor binding pocket; inhibition site 264462004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462004375 catalytic residue [active] 264462004376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462004377 dimer interface [polypeptide binding]; other site 264462004378 putative CheW interface [polypeptide binding]; other site 264462004379 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462004380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462004381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264462004382 HlyD family secretion protein; Region: HlyD_3; pfam13437 264462004383 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264462004384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264462004385 Walker A/P-loop; other site 264462004386 ATP binding site [chemical binding]; other site 264462004387 Q-loop/lid; other site 264462004388 ABC transporter signature motif; other site 264462004389 Walker B; other site 264462004390 D-loop; other site 264462004391 H-loop/switch region; other site 264462004392 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264462004393 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264462004394 Walker A/P-loop; other site 264462004395 ATP binding site [chemical binding]; other site 264462004396 Q-loop/lid; other site 264462004397 ABC transporter signature motif; other site 264462004398 Walker B; other site 264462004399 D-loop; other site 264462004400 H-loop/switch region; other site 264462004401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264462004402 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 264462004403 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 264462004404 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264462004405 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264462004406 dimer interface [polypeptide binding]; other site 264462004407 TIGR02147 family protein; Region: Fsuc_second 264462004408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462004409 non-specific DNA binding site [nucleotide binding]; other site 264462004410 salt bridge; other site 264462004411 sequence-specific DNA binding site [nucleotide binding]; other site 264462004412 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 264462004413 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264462004414 transmembrane helices; other site 264462004415 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462004416 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462004417 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 264462004418 GAF domain; Region: GAF; pfam01590 264462004419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462004420 Walker A motif; other site 264462004421 ATP binding site [chemical binding]; other site 264462004422 Walker B motif; other site 264462004423 arginine finger; other site 264462004424 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462004425 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462004426 active site 264462004427 substrate binding sites [chemical binding]; other site 264462004428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462004429 dimer interface [polypeptide binding]; other site 264462004430 phosphorylation site [posttranslational modification] 264462004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004432 ATP binding site [chemical binding]; other site 264462004433 Mg2+ binding site [ion binding]; other site 264462004434 G-X-G motif; other site 264462004435 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462004436 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 264462004437 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264462004438 TIGR02147 family protein; Region: Fsuc_second 264462004439 amino acid transporter; Region: 2A0306; TIGR00909 264462004440 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 264462004441 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264462004442 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264462004443 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264462004444 active site 264462004445 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 264462004446 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 264462004447 putative active site [active] 264462004448 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462004449 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462004450 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462004451 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462004452 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462004453 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462004454 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264462004455 hydrophobic ligand binding site; other site 264462004456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264462004457 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 264462004458 NAD(P) binding site [chemical binding]; other site 264462004459 catalytic residues [active] 264462004460 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 264462004461 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264462004462 Ligand Binding Site [chemical binding]; other site 264462004463 FtsH Extracellular; Region: FtsH_ext; pfam06480 264462004464 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264462004465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462004466 Walker A motif; other site 264462004467 ATP binding site [chemical binding]; other site 264462004468 Walker B motif; other site 264462004469 arginine finger; other site 264462004470 Peptidase family M41; Region: Peptidase_M41; pfam01434 264462004471 TIGR00159 family protein; Region: TIGR00159 264462004472 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 264462004473 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 264462004474 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264462004475 active site 264462004476 substrate binding site [chemical binding]; other site 264462004477 metal binding site [ion binding]; metal-binding site 264462004478 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 264462004479 active site 264462004480 hydrophilic channel; other site 264462004481 dimerization interface [polypeptide binding]; other site 264462004482 catalytic residues [active] 264462004483 active site lid [active] 264462004484 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 264462004485 Staphylococcal nuclease homologues; Region: SNc; smart00318 264462004486 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 264462004487 Catalytic site; other site 264462004488 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 264462004489 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264462004490 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 264462004491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462004492 catalytic residue [active] 264462004493 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 264462004494 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264462004495 Ligand Binding Site [chemical binding]; other site 264462004496 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 264462004497 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264462004498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462004499 FeS/SAM binding site; other site 264462004500 ribonuclease III; Reviewed; Region: rnc; PRK00102 264462004501 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264462004502 dimerization interface [polypeptide binding]; other site 264462004503 active site 264462004504 metal binding site [ion binding]; metal-binding site 264462004505 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264462004506 dsRNA binding site [nucleotide binding]; other site 264462004507 GTPase Era; Reviewed; Region: era; PRK00089 264462004508 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264462004509 G1 box; other site 264462004510 GTP/Mg2+ binding site [chemical binding]; other site 264462004511 Switch I region; other site 264462004512 G2 box; other site 264462004513 Switch II region; other site 264462004514 G3 box; other site 264462004515 G4 box; other site 264462004516 G5 box; other site 264462004517 KH domain; Region: KH_2; pfam07650 264462004518 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 264462004519 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264462004520 G1 box; other site 264462004521 GTP/Mg2+ binding site [chemical binding]; other site 264462004522 Switch I region; other site 264462004523 G2 box; other site 264462004524 Switch II region; other site 264462004525 G3 box; other site 264462004526 G4 box; other site 264462004527 G5 box; other site 264462004528 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264462004529 G1 box; other site 264462004530 GTP/Mg2+ binding site [chemical binding]; other site 264462004531 Switch I region; other site 264462004532 G2 box; other site 264462004533 G3 box; other site 264462004534 Switch II region; other site 264462004535 G4 box; other site 264462004536 G5 box; other site 264462004537 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 264462004538 Na2 binding site [ion binding]; other site 264462004539 putative substrate binding site 1 [chemical binding]; other site 264462004540 Na binding site 1 [ion binding]; other site 264462004541 putative substrate binding site 2 [chemical binding]; other site 264462004542 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264462004543 catalytic residues [active] 264462004544 dimer interface [polypeptide binding]; other site 264462004545 adenylosuccinate lyase; Provisional; Region: PRK07492 264462004546 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 264462004547 tetramer interface [polypeptide binding]; other site 264462004548 active site 264462004549 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 264462004550 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264462004551 dimer interface [polypeptide binding]; other site 264462004552 catalytic triad [active] 264462004553 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264462004554 Beta-lactamase; Region: Beta-lactamase; pfam00144 264462004555 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 264462004556 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264462004557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462004558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462004559 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264462004560 putative active site [active] 264462004561 Transposase IS200 like; Region: Y1_Tnp; cl00848 264462004562 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264462004563 MutS domain I; Region: MutS_I; pfam01624 264462004564 MutS domain III; Region: MutS_III; pfam05192 264462004565 MutS domain V; Region: MutS_V; pfam00488 264462004566 Walker A/P-loop; other site 264462004567 ATP binding site [chemical binding]; other site 264462004568 Q-loop/lid; other site 264462004569 ABC transporter signature motif; other site 264462004570 Walker B; other site 264462004571 D-loop; other site 264462004572 H-loop/switch region; other site 264462004573 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264462004574 metal binding triad [ion binding]; metal-binding site 264462004575 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264462004576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 264462004577 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264462004578 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 264462004579 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 264462004580 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 264462004581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264462004582 active site 264462004583 hypothetical protein; Provisional; Region: PRK12378 264462004584 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264462004585 dinuclear metal binding motif [ion binding]; other site 264462004586 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 264462004587 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264462004588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462004589 RNA binding surface [nucleotide binding]; other site 264462004590 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264462004591 active site 264462004592 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 264462004593 active site 264462004594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264462004595 classical (c) SDRs; Region: SDR_c; cd05233 264462004596 NAD(P) binding site [chemical binding]; other site 264462004597 active site 264462004598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462004599 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462004600 ligand binding site [chemical binding]; other site 264462004601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264462004602 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264462004603 peptide binding site [polypeptide binding]; other site 264462004604 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264462004605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264462004606 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 264462004607 FAD binding site [chemical binding]; other site 264462004608 homotetramer interface [polypeptide binding]; other site 264462004609 substrate binding pocket [chemical binding]; other site 264462004610 catalytic base [active] 264462004611 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 264462004612 Peptidase family M50; Region: Peptidase_M50; pfam02163 264462004613 active site 264462004614 putative substrate binding region [chemical binding]; other site 264462004615 ScpA/B protein; Region: ScpA_ScpB; cl00598 264462004616 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 264462004617 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 264462004618 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264462004619 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462004620 catalytic residues [active] 264462004621 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264462004622 dimer interface [polypeptide binding]; other site 264462004623 putative radical transfer pathway; other site 264462004624 diiron center [ion binding]; other site 264462004625 tyrosyl radical; other site 264462004626 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 264462004627 ATP cone domain; Region: ATP-cone; pfam03477 264462004628 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264462004629 active site 264462004630 dimer interface [polypeptide binding]; other site 264462004631 catalytic residues [active] 264462004632 effector binding site; other site 264462004633 R2 peptide binding site; other site 264462004634 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 264462004635 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 264462004636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004637 substrate binding pocket [chemical binding]; other site 264462004638 membrane-bound complex binding site; other site 264462004639 hinge residues; other site 264462004640 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264462004641 active site 264462004642 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 264462004643 GH3 auxin-responsive promoter; Region: GH3; pfam03321 264462004644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462004645 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264462004646 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264462004647 PilZ domain; Region: PilZ; pfam07238 264462004648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264462004649 Predicted flavoprotein [General function prediction only]; Region: COG0431 264462004650 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 264462004651 potassium uptake protein; Region: kup; TIGR00794 264462004652 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264462004653 active site 264462004654 nucleophile elbow; other site 264462004655 YceI-like domain; Region: YceI; pfam04264 264462004656 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 264462004657 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264462004658 Peptidase family M23; Region: Peptidase_M23; pfam01551 264462004659 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264462004660 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264462004661 dimer interface [polypeptide binding]; other site 264462004662 active site 264462004663 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264462004664 folate binding site [chemical binding]; other site 264462004665 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 264462004666 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264462004667 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 264462004668 dimer interface [polypeptide binding]; other site 264462004669 active site 264462004670 acyl carrier protein; Provisional; Region: acpP; PRK00982 264462004671 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264462004672 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264462004673 NAD(P) binding site [chemical binding]; other site 264462004674 homotetramer interface [polypeptide binding]; other site 264462004675 homodimer interface [polypeptide binding]; other site 264462004676 active site 264462004677 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264462004678 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264462004679 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264462004680 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264462004681 dimer interface [polypeptide binding]; other site 264462004682 active site 264462004683 CoA binding pocket [chemical binding]; other site 264462004684 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 264462004685 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 264462004686 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264462004687 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462004688 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 264462004689 putative homodimer interface [polypeptide binding]; other site 264462004690 putative homotetramer interface [polypeptide binding]; other site 264462004691 putative metal binding site [ion binding]; other site 264462004692 putative homodimer-homodimer interface [polypeptide binding]; other site 264462004693 putative allosteric switch controlling residues; other site 264462004694 Ferroportin1 (FPN1); Region: FPN1; pfam06963 264462004695 NMT1/THI5 like; Region: NMT1; pfam09084 264462004696 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264462004697 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264462004698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462004699 dimer interface [polypeptide binding]; other site 264462004700 conserved gate region; other site 264462004701 putative PBP binding loops; other site 264462004702 ABC-ATPase subunit interface; other site 264462004703 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264462004704 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264462004705 Walker A/P-loop; other site 264462004706 ATP binding site [chemical binding]; other site 264462004707 Q-loop/lid; other site 264462004708 ABC transporter signature motif; other site 264462004709 Walker B; other site 264462004710 D-loop; other site 264462004711 H-loop/switch region; other site 264462004712 conserved hypothetical protein; Region: TIGR02466 264462004713 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264462004714 active site 264462004715 catalytic residues [active] 264462004716 DNA binding site [nucleotide binding] 264462004717 Int/Topo IB signature motif; other site 264462004718 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 264462004719 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 264462004720 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 264462004721 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264462004722 active site 264462004723 HIGH motif; other site 264462004724 KMSK motif region; other site 264462004725 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 264462004726 tRNA binding surface [nucleotide binding]; other site 264462004727 anticodon binding site; other site 264462004728 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264462004729 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 264462004730 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 264462004731 NAD binding site [chemical binding]; other site 264462004732 Phe binding site; other site 264462004733 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264462004734 Trp docking motif [polypeptide binding]; other site 264462004735 active site 264462004736 PQQ-like domain; Region: PQQ_2; pfam13360 264462004737 Fic/DOC family; Region: Fic; pfam02661 264462004738 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264462004739 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264462004740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462004741 catalytic residue [active] 264462004742 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 264462004743 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 264462004744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264462004745 Beta-Casp domain; Region: Beta-Casp; smart01027 264462004746 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264462004747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462004748 active site 264462004749 motif I; other site 264462004750 motif II; other site 264462004751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462004753 substrate binding pocket [chemical binding]; other site 264462004754 membrane-bound complex binding site; other site 264462004755 hinge residues; other site 264462004756 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 264462004757 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 264462004758 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 264462004759 Phosphotransferase enzyme family; Region: APH; pfam01636 264462004760 active site 264462004761 substrate binding site [chemical binding]; other site 264462004762 ATP binding site [chemical binding]; other site 264462004763 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 264462004764 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462004765 KH domain; Region: KH_4; pfam13083 264462004766 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462004767 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 264462004768 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462004769 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462004770 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462004771 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462004772 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264462004773 PA_M28_1_3: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 3. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_3; cd04822 264462004774 PA/protease or protease-like domain interface [polypeptide binding]; other site 264462004775 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 264462004776 Peptidase family M28; Region: Peptidase_M28; pfam04389 264462004777 metal binding site [ion binding]; metal-binding site 264462004778 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462004779 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264462004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462004781 S-adenosylmethionine binding site [chemical binding]; other site 264462004782 PilZ domain; Region: PilZ; pfam07238 264462004783 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462004784 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264462004785 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264462004786 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 264462004787 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264462004788 Ligand Binding Site [chemical binding]; other site 264462004789 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 264462004790 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264462004791 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264462004792 C-terminal domain interface [polypeptide binding]; other site 264462004793 GSH binding site (G-site) [chemical binding]; other site 264462004794 dimer interface [polypeptide binding]; other site 264462004795 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 264462004796 dimer interface [polypeptide binding]; other site 264462004797 N-terminal domain interface [polypeptide binding]; other site 264462004798 Peptidase family M48; Region: Peptidase_M48; pfam01435 264462004799 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 264462004800 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264462004801 dimer interface [polypeptide binding]; other site 264462004802 active site 264462004803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462004804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462004805 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264462004806 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 264462004807 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264462004808 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264462004809 ligand binding site [chemical binding]; other site 264462004810 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264462004811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264462004812 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462004813 substrate binding pocket [chemical binding]; other site 264462004814 membrane-bound complex binding site; other site 264462004815 hinge residues; other site 264462004816 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264462004817 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 264462004818 active site 264462004819 PHP Thumb interface [polypeptide binding]; other site 264462004820 metal binding site [ion binding]; metal-binding site 264462004821 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264462004822 generic binding surface II; other site 264462004823 generic binding surface I; other site 264462004824 adenylosuccinate synthase; Region: purA; TIGR00184 264462004825 GMP synthase; Reviewed; Region: guaA; PRK00074 264462004826 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264462004827 AMP/PPi binding site [chemical binding]; other site 264462004828 candidate oxyanion hole; other site 264462004829 catalytic triad [active] 264462004830 potential glutamine specificity residues [chemical binding]; other site 264462004831 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264462004832 ATP Binding subdomain [chemical binding]; other site 264462004833 Ligand Binding sites [chemical binding]; other site 264462004834 Dimerization subdomain; other site 264462004835 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264462004836 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264462004837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 264462004838 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264462004839 active site 264462004840 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264462004841 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264462004842 trimer interface [polypeptide binding]; other site 264462004843 putative metal binding site [ion binding]; other site 264462004844 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264462004845 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264462004846 active site 264462004847 nucleophile elbow; other site 264462004848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264462004849 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264462004850 TrkA-C domain; Region: TrkA_C; pfam02080 264462004851 TrkA-C domain; Region: TrkA_C; pfam02080 264462004852 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 264462004853 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264462004854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462004855 FeS/SAM binding site; other site 264462004856 TRAM domain; Region: TRAM; pfam01938 264462004857 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462004858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462004859 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462004860 substrate binding pocket [chemical binding]; other site 264462004861 membrane-bound complex binding site; other site 264462004862 hinge residues; other site 264462004863 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 264462004864 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 264462004865 putative acyltransferase; Provisional; Region: PRK05790 264462004866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264462004867 dimer interface [polypeptide binding]; other site 264462004868 active site 264462004869 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 264462004870 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 264462004871 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462004872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462004873 ligand binding site [chemical binding]; other site 264462004874 flexible hinge region; other site 264462004875 pyruvate kinase; Provisional; Region: PRK05826 264462004876 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264462004877 domain interfaces; other site 264462004878 active site 264462004879 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264462004880 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462004881 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264462004882 IHF dimer interface [polypeptide binding]; other site 264462004883 IHF - DNA interface [nucleotide binding]; other site 264462004884 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264462004885 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264462004886 Protein of unknown function, DUF399; Region: DUF399; cl01139 264462004887 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 264462004888 putative active site [active] 264462004889 redox center [active] 264462004890 Thioredoxin; Region: Thioredoxin_4; cl17273 264462004891 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264462004892 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264462004893 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264462004894 anti sigma factor interaction site; other site 264462004895 regulatory phosphorylation site [posttranslational modification]; other site 264462004896 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 264462004897 OstA-like protein; Region: OstA; cl00844 264462004898 Organic solvent tolerance protein; Region: OstA_C; pfam04453 264462004899 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 264462004900 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264462004901 RNA/DNA hybrid binding site [nucleotide binding]; other site 264462004902 active site 264462004903 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264462004904 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 264462004905 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264462004906 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264462004907 RimM N-terminal domain; Region: RimM; pfam01782 264462004908 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462004909 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 264462004910 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 264462004911 signal recognition particle protein; Provisional; Region: PRK10867 264462004912 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264462004913 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264462004914 P loop; other site 264462004915 GTP binding site [chemical binding]; other site 264462004916 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264462004917 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 264462004918 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264462004919 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264462004920 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264462004921 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 264462004922 Walker A/P-loop; other site 264462004923 ATP binding site [chemical binding]; other site 264462004924 Q-loop/lid; other site 264462004925 ABC transporter signature motif; other site 264462004926 Walker B; other site 264462004927 D-loop; other site 264462004928 H-loop/switch region; other site 264462004929 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264462004930 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264462004931 G1 box; other site 264462004932 putative GEF interaction site [polypeptide binding]; other site 264462004933 GTP/Mg2+ binding site [chemical binding]; other site 264462004934 Switch I region; other site 264462004935 G2 box; other site 264462004936 G3 box; other site 264462004937 Switch II region; other site 264462004938 G4 box; other site 264462004939 G5 box; other site 264462004940 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264462004941 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 264462004942 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 264462004943 active site residue [active] 264462004944 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 264462004945 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264462004946 SlyX; Region: SlyX; pfam04102 264462004947 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264462004948 RNA/DNA hybrid binding site [nucleotide binding]; other site 264462004949 active site 264462004950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462004951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462004952 active site 264462004953 phosphorylation site [posttranslational modification] 264462004954 intermolecular recognition site; other site 264462004955 dimerization interface [polypeptide binding]; other site 264462004956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264462004957 DNA binding residues [nucleotide binding] 264462004958 dimerization interface [polypeptide binding]; other site 264462004959 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 264462004960 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264462004961 active site 264462004962 catalytic site [active] 264462004963 substrate binding site [chemical binding]; other site 264462004964 GAF domain; Region: GAF; pfam01590 264462004965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462004966 dimer interface [polypeptide binding]; other site 264462004967 phosphorylation site [posttranslational modification] 264462004968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462004969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462004970 ATP binding site [chemical binding]; other site 264462004971 Mg2+ binding site [ion binding]; other site 264462004972 G-X-G motif; other site 264462004973 Response regulator receiver domain; Region: Response_reg; pfam00072 264462004974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462004975 active site 264462004976 phosphorylation site [posttranslational modification] 264462004977 intermolecular recognition site; other site 264462004978 dimerization interface [polypeptide binding]; other site 264462004979 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264462004980 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264462004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462004982 Walker A motif; other site 264462004983 ATP binding site [chemical binding]; other site 264462004984 Walker B motif; other site 264462004985 arginine finger; other site 264462004986 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264462004987 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264462004988 TrkA-C domain; Region: TrkA_C; pfam02080 264462004989 TrkA-C domain; Region: TrkA_C; pfam02080 264462004990 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 264462004991 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264462004992 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 264462004993 dimer interface [polypeptide binding]; other site 264462004994 FMN binding site [chemical binding]; other site 264462004995 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 264462004996 dimer interface [polypeptide binding]; other site 264462004997 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264462004998 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264462004999 fumarate hydratase; Provisional; Region: PRK15389 264462005000 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 264462005001 Fumarase C-terminus; Region: Fumerase_C; pfam05683 264462005002 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 264462005003 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462005004 Ligand Binding Site [chemical binding]; other site 264462005005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462005006 Ligand Binding Site [chemical binding]; other site 264462005007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462005008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264462005009 DNA binding residues [nucleotide binding] 264462005010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462005011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462005012 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264462005013 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264462005014 FMN binding site [chemical binding]; other site 264462005015 substrate binding site [chemical binding]; other site 264462005016 putative catalytic residue [active] 264462005017 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 264462005018 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264462005019 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264462005020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462005021 putative substrate translocation pore; other site 264462005022 hypothetical protein; Provisional; Region: PRK09256 264462005023 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 264462005024 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 264462005025 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 264462005026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462005027 Zn2+ binding site [ion binding]; other site 264462005028 Mg2+ binding site [ion binding]; other site 264462005029 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462005030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462005031 active site 264462005032 phosphorylation site [posttranslational modification] 264462005033 intermolecular recognition site; other site 264462005034 Domain of unknown function DUF21; Region: DUF21; pfam01595 264462005035 FOG: CBS domain [General function prediction only]; Region: COG0517 264462005036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264462005037 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 264462005038 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264462005039 putative Cl- selectivity filter; other site 264462005040 putative pore gating glutamate residue; other site 264462005041 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 264462005042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264462005043 active site 264462005044 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 264462005045 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264462005046 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264462005047 DNA binding site [nucleotide binding] 264462005048 catalytic residue [active] 264462005049 H2TH interface [polypeptide binding]; other site 264462005050 putative catalytic residues [active] 264462005051 turnover-facilitating residue; other site 264462005052 intercalation triad [nucleotide binding]; other site 264462005053 8OG recognition residue [nucleotide binding]; other site 264462005054 putative reading head residues; other site 264462005055 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264462005056 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264462005057 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 264462005058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462005059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462005060 ATP binding site [chemical binding]; other site 264462005061 Mg2+ binding site [ion binding]; other site 264462005062 G-X-G motif; other site 264462005063 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 264462005064 putative inner membrane peptidase; Provisional; Region: PRK11778 264462005065 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264462005066 tandem repeat interface [polypeptide binding]; other site 264462005067 oligomer interface [polypeptide binding]; other site 264462005068 active site residues [active] 264462005069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264462005070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264462005071 Walker A/P-loop; other site 264462005072 ATP binding site [chemical binding]; other site 264462005073 Q-loop/lid; other site 264462005074 ABC transporter signature motif; other site 264462005075 Walker B; other site 264462005076 D-loop; other site 264462005077 H-loop/switch region; other site 264462005078 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264462005079 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264462005080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264462005081 Walker A/P-loop; other site 264462005082 ATP binding site [chemical binding]; other site 264462005083 Q-loop/lid; other site 264462005084 ABC transporter signature motif; other site 264462005085 Walker B; other site 264462005086 D-loop; other site 264462005087 H-loop/switch region; other site 264462005088 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264462005089 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264462005090 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 264462005091 peptide binding site [polypeptide binding]; other site 264462005092 dimer interface [polypeptide binding]; other site 264462005093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264462005094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462005095 dimer interface [polypeptide binding]; other site 264462005096 conserved gate region; other site 264462005097 putative PBP binding loops; other site 264462005098 ABC-ATPase subunit interface; other site 264462005099 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264462005100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264462005101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462005102 dimer interface [polypeptide binding]; other site 264462005103 conserved gate region; other site 264462005104 putative PBP binding loops; other site 264462005105 ABC-ATPase subunit interface; other site 264462005106 conserved hypothetical protein; Region: TIGR02285 264462005107 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 264462005108 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 264462005109 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264462005110 Di-iron ligands [ion binding]; other site 264462005111 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 264462005112 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 264462005113 active site 264462005114 catalytic site [active] 264462005115 metal binding site [ion binding]; metal-binding site 264462005116 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264462005117 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264462005118 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264462005119 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264462005120 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264462005121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264462005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462005123 TIGR01777 family protein; Region: yfcH 264462005124 NAD(P) binding site [chemical binding]; other site 264462005125 active site 264462005126 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 264462005127 putative hydrophobic ligand binding site [chemical binding]; other site 264462005128 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 264462005129 DNA photolyase; Region: DNA_photolyase; pfam00875 264462005130 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264462005131 ABC1 family; Region: ABC1; cl17513 264462005132 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264462005133 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462005134 catalytic residues [active] 264462005135 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 264462005136 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 264462005137 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 264462005138 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 264462005139 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 264462005140 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264462005141 active site 264462005142 8-oxo-dGMP binding site [chemical binding]; other site 264462005143 nudix motif; other site 264462005144 metal binding site [ion binding]; metal-binding site 264462005145 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264462005146 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264462005147 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264462005148 PhoU domain; Region: PhoU; pfam01895 264462005149 PhoU domain; Region: PhoU; pfam01895 264462005150 Protein of unknown function, DUF486; Region: DUF486; cl01236 264462005151 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264462005152 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264462005153 metal-binding site [ion binding] 264462005154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264462005155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462005156 motif II; other site 264462005157 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 264462005158 putative homodimer interface [polypeptide binding]; other site 264462005159 putative homotetramer interface [polypeptide binding]; other site 264462005160 putative allosteric switch controlling residues; other site 264462005161 putative metal binding site [ion binding]; other site 264462005162 putative homodimer-homodimer interface [polypeptide binding]; other site 264462005163 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264462005164 Protein export membrane protein; Region: SecD_SecF; cl14618 264462005165 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264462005166 Domain of unknown function (DUF366); Region: DUF366; pfam04017 264462005167 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264462005168 Ligand Binding Site [chemical binding]; other site 264462005169 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 264462005170 DHH family; Region: DHH; pfam01368 264462005171 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264462005172 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264462005173 Protein export membrane protein; Region: SecD_SecF; pfam02355 264462005174 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 264462005175 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264462005176 Preprotein translocase subunit; Region: YajC; pfam02699 264462005177 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 264462005178 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264462005179 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 264462005180 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 264462005181 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 264462005182 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264462005183 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 264462005184 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264462005185 active site 264462005186 FMN binding site [chemical binding]; other site 264462005187 substrate binding site [chemical binding]; other site 264462005188 3Fe-4S cluster binding site [ion binding]; other site 264462005189 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462005190 OmpA family; Region: OmpA; pfam00691 264462005191 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 264462005192 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264462005193 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264462005194 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 264462005195 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 264462005196 [2Fe-2S] cluster binding site [ion binding]; other site 264462005197 BON domain; Region: BON; pfam04972 264462005198 BON domain; Region: BON; pfam04972 264462005199 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264462005200 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264462005201 inhibitor-cofactor binding pocket; inhibition site 264462005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462005203 catalytic residue [active] 264462005204 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264462005205 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 264462005206 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264462005207 active site 264462005208 DNA binding site [nucleotide binding] 264462005209 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264462005210 DNA binding site [nucleotide binding] 264462005211 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264462005212 nucleotide binding site [chemical binding]; other site 264462005213 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264462005214 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264462005215 putative DNA binding site [nucleotide binding]; other site 264462005216 putative homodimer interface [polypeptide binding]; other site 264462005217 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264462005218 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264462005219 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264462005220 homodimer interaction site [polypeptide binding]; other site 264462005221 cofactor binding site; other site 264462005222 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 264462005223 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264462005224 HIGH motif; other site 264462005225 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264462005226 active site 264462005227 KMSKS motif; other site 264462005228 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 264462005229 tRNA binding surface [nucleotide binding]; other site 264462005230 anticodon binding site; other site 264462005231 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264462005232 active site clefts [active] 264462005233 zinc binding site [ion binding]; other site 264462005234 dimer interface [polypeptide binding]; other site 264462005235 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264462005236 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 264462005237 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264462005238 conserved cys residue [active] 264462005239 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264462005240 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 264462005241 NAD(P) binding site [chemical binding]; other site 264462005242 catalytic residues [active] 264462005243 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264462005244 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264462005245 TrkA-C domain; Region: TrkA_C; pfam02080 264462005246 TrkA-C domain; Region: TrkA_C; pfam02080 264462005247 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 264462005248 active site 264462005249 catalytic residues [active] 264462005250 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 264462005251 PA/protease domain interface [polypeptide binding]; other site 264462005252 putative integrin binding motif; other site 264462005253 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264462005254 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 264462005255 catalytic residues [active] 264462005256 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 264462005257 Ligand binding site; other site 264462005258 Ligand binding site; other site 264462005259 Ligand binding site; other site 264462005260 Putative Catalytic site; other site 264462005261 DXD motif; other site 264462005262 Site-specific recombinase; Region: SpecificRecomb; pfam10136 264462005263 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 264462005264 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462005265 putative catalytic residue [active] 264462005266 YtkA-like; Region: YtkA; pfam13115 264462005267 YtkA-like; Region: YtkA; pfam13115 264462005268 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462005269 KH domain; Region: KH_4; pfam13083 264462005270 HutD; Region: HutD; pfam05962 264462005271 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 264462005272 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 264462005273 Ca binding site [ion binding]; other site 264462005274 active site 264462005275 catalytic site [active] 264462005276 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 264462005277 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 264462005278 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 264462005279 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264462005280 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 264462005281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264462005282 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 264462005283 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 264462005284 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 264462005285 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264462005286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462005287 motif II; other site 264462005288 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264462005289 Methyltransferase domain; Region: Methyltransf_11; pfam08241 264462005290 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 264462005291 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 264462005292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264462005293 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264462005294 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264462005295 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264462005296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462005297 Walker A motif; other site 264462005298 ATP binding site [chemical binding]; other site 264462005299 Walker B motif; other site 264462005300 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264462005301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264462005302 active site 264462005303 Int/Topo IB signature motif; other site 264462005304 DNA binding site [nucleotide binding] 264462005305 Stage II sporulation protein; Region: SpoIID; pfam08486 264462005306 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 264462005307 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264462005308 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264462005309 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 264462005310 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 264462005311 active site residues [active] 264462005312 dimer interface [polypeptide binding]; other site 264462005313 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 264462005314 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 264462005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462005316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264462005317 putative substrate translocation pore; other site 264462005318 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264462005319 MviN-like protein; Region: MVIN; pfam03023 264462005320 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264462005321 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264462005322 GIY-YIG motif/motif A; other site 264462005323 active site 264462005324 catalytic site [active] 264462005325 putative DNA binding site [nucleotide binding]; other site 264462005326 metal binding site [ion binding]; metal-binding site 264462005327 UvrB/uvrC motif; Region: UVR; pfam02151 264462005328 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264462005329 excinuclease ABC subunit B; Provisional; Region: PRK05298 264462005330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462005331 ATP binding site [chemical binding]; other site 264462005332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462005333 nucleotide binding region [chemical binding]; other site 264462005334 ATP-binding site [chemical binding]; other site 264462005335 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264462005336 UvrB/uvrC motif; Region: UVR; pfam02151 264462005337 Penicillin amidase; Region: Penicil_amidase; pfam01804 264462005338 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264462005339 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 264462005340 active site 264462005341 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 264462005342 Domain of unknown function (DUF333); Region: DUF333; pfam03891 264462005343 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264462005344 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264462005345 active site 264462005346 HIGH motif; other site 264462005347 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264462005348 KMSKS motif; other site 264462005349 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264462005350 tRNA binding surface [nucleotide binding]; other site 264462005351 anticodon binding site; other site 264462005352 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264462005353 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264462005354 HIGH motif; other site 264462005355 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264462005356 active site 264462005357 KMSKS motif; other site 264462005358 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 264462005359 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264462005360 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 264462005361 active site 264462005362 catalytic triad [active] 264462005363 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264462005364 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264462005365 ssDNA binding site; other site 264462005366 generic binding surface II; other site 264462005367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462005368 ATP binding site [chemical binding]; other site 264462005369 putative Mg++ binding site [ion binding]; other site 264462005370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462005371 nucleotide binding region [chemical binding]; other site 264462005372 ATP-binding site [chemical binding]; other site 264462005373 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264462005374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462005375 Zn2+ binding site [ion binding]; other site 264462005376 Mg2+ binding site [ion binding]; other site 264462005377 Haem-binding domain; Region: Haem_bd; pfam14376 264462005378 putative protease; Provisional; Region: PRK15452 264462005379 Peptidase family U32; Region: Peptidase_U32; pfam01136 264462005380 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264462005381 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462005382 P-loop; other site 264462005383 Magnesium ion binding site [ion binding]; other site 264462005384 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462005385 Magnesium ion binding site [ion binding]; other site 264462005386 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 264462005387 cleavage site 264462005388 active site 264462005389 substrate binding sites [chemical binding]; other site 264462005390 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 264462005391 Trypsin; Region: Trypsin; pfam00089 264462005392 active site 264462005393 substrate binding sites [chemical binding]; other site 264462005394 MASE1; Region: MASE1; cl17823 264462005395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462005396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462005397 dimer interface [polypeptide binding]; other site 264462005398 phosphorylation site [posttranslational modification] 264462005399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462005400 ATP binding site [chemical binding]; other site 264462005401 Mg2+ binding site [ion binding]; other site 264462005402 G-X-G motif; other site 264462005403 Response regulator receiver domain; Region: Response_reg; pfam00072 264462005404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462005405 active site 264462005406 phosphorylation site [posttranslational modification] 264462005407 intermolecular recognition site; other site 264462005408 dimerization interface [polypeptide binding]; other site 264462005409 Rhodanese Homology Domain; Region: RHOD; smart00450 264462005410 active site residue [active] 264462005411 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462005412 active site residue [active] 264462005413 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264462005414 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264462005415 dimer interface [polypeptide binding]; other site 264462005416 putative anticodon binding site; other site 264462005417 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264462005418 motif 1; other site 264462005419 active site 264462005420 motif 2; other site 264462005421 motif 3; other site 264462005422 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 264462005423 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 264462005424 putative active site; other site 264462005425 catalytic residue [active] 264462005426 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 264462005427 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 264462005428 putative efflux protein, MATE family; Region: matE; TIGR00797 264462005429 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 264462005430 cation binding site [ion binding]; other site 264462005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462005432 metabolite-proton symporter; Region: 2A0106; TIGR00883 264462005433 putative substrate translocation pore; other site 264462005434 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264462005435 ABC1 family; Region: ABC1; cl17513 264462005436 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462005437 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 264462005438 MOSC domain; Region: MOSC; pfam03473 264462005439 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 264462005440 deoxyhypusine synthase; Region: dhys; TIGR00321 264462005441 Deoxyhypusine synthase; Region: DS; cl00826 264462005442 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462005443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462005444 S-adenosylmethionine binding site [chemical binding]; other site 264462005445 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 264462005446 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264462005447 putative ATP binding site [chemical binding]; other site 264462005448 putative substrate interface [chemical binding]; other site 264462005449 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264462005450 active site 264462005451 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264462005452 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 264462005453 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462005454 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462005455 active site 264462005456 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264462005457 putative catalytic site [active] 264462005458 putative metal binding site [ion binding]; other site 264462005459 putative phosphate binding site [ion binding]; other site 264462005460 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264462005461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264462005462 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264462005463 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264462005464 putative active site [active] 264462005465 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 264462005466 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264462005467 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264462005468 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462005469 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264462005470 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264462005471 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264462005472 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264462005473 Cl- selectivity filter; other site 264462005474 Cl- binding residues [ion binding]; other site 264462005475 pore gating glutamate residue; other site 264462005476 dimer interface [polypeptide binding]; other site 264462005477 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 264462005478 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264462005479 putative active site [active] 264462005480 putative metal binding site [ion binding]; other site 264462005481 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264462005482 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264462005483 intersubunit interface [polypeptide binding]; other site 264462005484 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264462005485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264462005486 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264462005487 PLD-like domain; Region: PLDc_2; pfam13091 264462005488 putative active site [active] 264462005489 catalytic site [active] 264462005490 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 264462005491 PLD-like domain; Region: PLDc_2; pfam13091 264462005492 putative active site [active] 264462005493 catalytic site [active] 264462005494 Predicted ATPase [General function prediction only]; Region: COG3911 264462005495 AAA domain; Region: AAA_28; pfam13521 264462005496 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 264462005497 active site 264462005498 catalytic triad [active] 264462005499 oxyanion hole [active] 264462005500 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264462005501 active site 264462005502 NTP binding site [chemical binding]; other site 264462005503 metal binding triad [ion binding]; metal-binding site 264462005504 antibiotic binding site [chemical binding]; other site 264462005505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264462005506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264462005507 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 264462005508 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 264462005509 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 264462005510 thioester formation/cholesterol transfer; other site 264462005511 Response regulator receiver domain; Region: Response_reg; pfam00072 264462005512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462005513 active site 264462005514 phosphorylation site [posttranslational modification] 264462005515 intermolecular recognition site; other site 264462005516 dimerization interface [polypeptide binding]; other site 264462005517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462005518 dimerization interface [polypeptide binding]; other site 264462005519 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264462005520 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264462005521 FecR protein; Region: FecR; pfam04773 264462005522 PAS fold; Region: PAS_4; pfam08448 264462005523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264462005524 putative active site [active] 264462005525 heme pocket [chemical binding]; other site 264462005526 PAS fold; Region: PAS_4; pfam08448 264462005527 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264462005528 putative binding surface; other site 264462005529 active site 264462005530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462005531 ATP binding site [chemical binding]; other site 264462005532 Mg2+ binding site [ion binding]; other site 264462005533 G-X-G motif; other site 264462005534 superoxide dismutase; Provisional; Region: PRK10543 264462005535 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264462005536 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264462005537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264462005538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462005539 non-specific DNA binding site [nucleotide binding]; other site 264462005540 salt bridge; other site 264462005541 sequence-specific DNA binding site [nucleotide binding]; other site 264462005542 Cupin domain; Region: Cupin_2; pfam07883 264462005543 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264462005544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462005545 active site 264462005546 phosphorylation site [posttranslational modification] 264462005547 intermolecular recognition site; other site 264462005548 dimerization interface [polypeptide binding]; other site 264462005549 Protein of unknown function, DUF399; Region: DUF399; pfam04187 264462005550 ribosomal protein L33; Region: rpl33; CHL00104 264462005551 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264462005552 trimer interface [polypeptide binding]; other site 264462005553 active site 264462005554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462005555 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 264462005556 putative active site [active] 264462005557 Zn binding site [ion binding]; other site 264462005558 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 264462005559 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264462005560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462005561 Zn2+ binding site [ion binding]; other site 264462005562 Mg2+ binding site [ion binding]; other site 264462005563 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 264462005564 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462005565 catalytic triad [active] 264462005566 putative active site [active] 264462005567 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 264462005568 active site 264462005569 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264462005570 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 264462005571 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264462005572 active site 264462005573 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 264462005574 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264462005575 FMN reductase; Validated; Region: fre; PRK08051 264462005576 FAD binding pocket [chemical binding]; other site 264462005577 conserved FAD binding motif [chemical binding]; other site 264462005578 phosphate binding motif [ion binding]; other site 264462005579 beta-alpha-beta structure motif; other site 264462005580 NAD binding pocket [chemical binding]; other site 264462005581 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264462005582 EamA-like transporter family; Region: EamA; pfam00892 264462005583 EamA-like transporter family; Region: EamA; pfam00892 264462005584 hypothetical protein; Provisional; Region: PRK14013 264462005585 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264462005586 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264462005587 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264462005588 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264462005589 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264462005590 metal binding site 2 [ion binding]; metal-binding site 264462005591 putative DNA binding helix; other site 264462005592 metal binding site 1 [ion binding]; metal-binding site 264462005593 dimer interface [polypeptide binding]; other site 264462005594 structural Zn2+ binding site [ion binding]; other site 264462005595 putative GTP cyclohydrolase; Provisional; Region: PRK13674 264462005596 Maf-like protein; Region: Maf; pfam02545 264462005597 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264462005598 active site 264462005599 dimer interface [polypeptide binding]; other site 264462005600 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 264462005601 active site 264462005602 catalytic motif [active] 264462005603 Zn binding site [ion binding]; other site 264462005604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462005605 substrate binding pocket [chemical binding]; other site 264462005606 membrane-bound complex binding site; other site 264462005607 hinge residues; other site 264462005608 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264462005609 putative catalytic site [active] 264462005610 putative metal binding site [ion binding]; other site 264462005611 putative phosphate binding site [ion binding]; other site 264462005612 SurA N-terminal domain; Region: SurA_N_3; cl07813 264462005613 rod shape-determining protein MreC; Provisional; Region: PRK13922 264462005614 rod shape-determining protein MreC; Region: MreC; pfam04085 264462005615 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264462005616 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264462005617 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264462005618 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 264462005619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462005620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462005621 catalytic residue [active] 264462005622 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 264462005623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264462005624 catalytic residues [active] 264462005625 Predicted permeases [General function prediction only]; Region: COG0795 264462005626 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264462005627 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 264462005628 DNA protecting protein DprA; Region: dprA; TIGR00732 264462005629 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264462005630 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462005631 Competence protein; Region: Competence; pfam03772 264462005632 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 264462005633 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264462005634 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 264462005635 hexamer interface [polypeptide binding]; other site 264462005636 ligand binding site [chemical binding]; other site 264462005637 putative active site [active] 264462005638 NAD(P) binding site [chemical binding]; other site 264462005639 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 264462005640 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 264462005641 L-asparaginase II; Region: Asparaginase_II; pfam06089 264462005642 Calx-beta domain; Region: Calx-beta; cl02522 264462005643 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462005644 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462005645 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462005646 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462005647 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462005648 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264462005649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462005650 Walker A motif; other site 264462005651 ATP binding site [chemical binding]; other site 264462005652 Walker B motif; other site 264462005653 arginine finger; other site 264462005654 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264462005655 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264462005656 RuvA N terminal domain; Region: RuvA_N; pfam01330 264462005657 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264462005658 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264462005659 active site 264462005660 putative DNA-binding cleft [nucleotide binding]; other site 264462005661 dimer interface [polypeptide binding]; other site 264462005662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462005663 TPR motif; other site 264462005664 binding surface 264462005665 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462005666 elongation factor P; Validated; Region: PRK00529 264462005667 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264462005668 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264462005669 RNA binding site [nucleotide binding]; other site 264462005670 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264462005671 RNA binding site [nucleotide binding]; other site 264462005672 Family of unknown function (DUF490); Region: DUF490; pfam04357 264462005673 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462005674 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 264462005675 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462005676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264462005677 Surface antigen; Region: Bac_surface_Ag; pfam01103 264462005678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264462005679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462005680 non-specific DNA binding site [nucleotide binding]; other site 264462005681 salt bridge; other site 264462005682 sequence-specific DNA binding site [nucleotide binding]; other site 264462005683 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264462005684 active site 264462005685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264462005686 active site 2 [active] 264462005687 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 264462005688 putative heme binding site [chemical binding]; other site 264462005689 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 264462005690 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264462005691 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264462005692 tetramer interface [polypeptide binding]; other site 264462005693 active site 264462005694 Mg2+/Mn2+ binding site [ion binding]; other site 264462005695 Cache domain; Region: Cache_1; pfam02743 264462005696 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462005697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462005698 dimer interface [polypeptide binding]; other site 264462005699 putative CheW interface [polypeptide binding]; other site 264462005700 Cache domain; Region: Cache_1; pfam02743 264462005701 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462005702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462005703 dimer interface [polypeptide binding]; other site 264462005704 putative CheW interface [polypeptide binding]; other site 264462005705 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264462005706 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 264462005707 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264462005708 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 264462005709 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264462005710 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264462005711 active site 264462005712 metal binding site [ion binding]; metal-binding site 264462005713 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 264462005714 citrate synthase; Provisional; Region: PRK14033 264462005715 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 264462005716 dimer interface [polypeptide binding]; other site 264462005717 active site 264462005718 citrylCoA binding site [chemical binding]; other site 264462005719 oxalacetate/citrate binding site [chemical binding]; other site 264462005720 coenzyme A binding site [chemical binding]; other site 264462005721 catalytic triad [active] 264462005722 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264462005723 putative active site [active] 264462005724 putative metal binding site [ion binding]; other site 264462005725 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264462005726 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 264462005727 apolar tunnel; other site 264462005728 heme binding site [chemical binding]; other site 264462005729 dimerization interface [polypeptide binding]; other site 264462005730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462005731 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 264462005732 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264462005733 dimerization interface [polypeptide binding]; other site 264462005734 peroxiredoxin; Region: AhpC; TIGR03137 264462005735 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264462005736 dimer interface [polypeptide binding]; other site 264462005737 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264462005738 catalytic triad [active] 264462005739 peroxidatic and resolving cysteines [active] 264462005740 alkyl hydroperoxide reductase subunit F; Region: AhpF; TIGR03140 264462005741 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 264462005742 catalytic residue [active] 264462005743 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 264462005744 catalytic residues [active] 264462005745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264462005746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462005747 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 264462005748 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264462005749 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264462005750 structural tetrad; other site 264462005751 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462005752 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462005753 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264462005754 active site 264462005755 metal binding site [ion binding]; metal-binding site 264462005756 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 264462005757 aminopeptidase N, Escherichia coli type; Region: pepN_proteo; TIGR02414 264462005758 active site 264462005759 Zn binding site [ion binding]; other site 264462005760 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 264462005761 GTP cyclohydrolase I; Provisional; Region: PLN03044 264462005762 active site 264462005763 PilZ domain; Region: PilZ; pfam07238 264462005764 YceI-like domain; Region: YceI; pfam04264 264462005765 Cytochrome c; Region: Cytochrom_C; pfam00034 264462005766 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462005767 cleavage site 264462005768 active site 264462005769 substrate binding sites [chemical binding]; other site 264462005770 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 264462005771 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 264462005772 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 264462005773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 264462005774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462005775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462005776 ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; Region: ABCC_MRP_domain1; cd03250 264462005777 Walker A/P-loop; other site 264462005778 ATP binding site [chemical binding]; other site 264462005779 Q-loop/lid; other site 264462005780 ABC transporter signature motif; other site 264462005781 Walker B; other site 264462005782 D-loop; other site 264462005783 H-loop/switch region; other site 264462005784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462005785 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462005786 ATP-binding cassette domain 2 of multidrug resistance-associated protein; Region: ABCC_MRP_domain2; cd03244 264462005787 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 264462005788 MgtE intracellular N domain; Region: MgtE_N; pfam03448 264462005789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 264462005790 Divalent cation transporter; Region: MgtE; pfam01769 264462005791 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462005792 catalytic triad [active] 264462005793 putative active site [active] 264462005794 PilZ domain; Region: PilZ; pfam07238 264462005795 Protein of unknown function (DUF502); Region: DUF502; cl01107 264462005796 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462005797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462005798 non-specific DNA binding site [nucleotide binding]; other site 264462005799 salt bridge; other site 264462005800 TIGR02147 family protein; Region: Fsuc_second 264462005801 sequence-specific DNA binding site [nucleotide binding]; other site 264462005802 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264462005803 interface (dimer of trimers) [polypeptide binding]; other site 264462005804 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 264462005805 Substrate-binding/catalytic site; other site 264462005806 Zn-binding sites [ion binding]; other site 264462005807 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264462005808 putative catalytic site [active] 264462005809 putative metal binding site [ion binding]; other site 264462005810 putative phosphate binding site [ion binding]; other site 264462005811 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 264462005812 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264462005813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264462005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462005815 non-specific DNA binding site [nucleotide binding]; other site 264462005816 salt bridge; other site 264462005817 sequence-specific DNA binding site [nucleotide binding]; other site 264462005818 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462005819 Uncharacterized conserved protein [Function unknown]; Region: COG5276 264462005820 Uncharacterized conserved protein [Function unknown]; Region: COG5276 264462005821 LVIVD repeat; Region: LVIVD; pfam08309 264462005822 LVIVD repeat; Region: LVIVD; pfam08309 264462005823 Uncharacterized conserved protein [Function unknown]; Region: COG5276 264462005824 LVIVD repeat; Region: LVIVD; pfam08309 264462005825 LVIVD repeat; Region: LVIVD; pfam08309 264462005826 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462005827 basic region leucin zipper; Region: BRLZ; smart00338 264462005828 pseudoazurin; Region: pseudoazurin; TIGR02375 264462005829 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 264462005830 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 264462005831 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264462005832 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 264462005833 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264462005834 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264462005835 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264462005836 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 264462005837 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264462005838 active site residue [active] 264462005839 AAA domain; Region: AAA_17; pfam13207 264462005840 selenophosphate synthetase; Provisional; Region: PRK00943 264462005841 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 264462005842 dimerization interface [polypeptide binding]; other site 264462005843 putative ATP binding site [chemical binding]; other site 264462005844 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 264462005845 Sulfatase; Region: Sulfatase; cl17466 264462005846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462005847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462005848 active site 264462005849 phosphorylation site [posttranslational modification] 264462005850 intermolecular recognition site; other site 264462005851 dimerization interface [polypeptide binding]; other site 264462005852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462005853 DNA binding site [nucleotide binding] 264462005854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462005855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462005856 dimerization interface [polypeptide binding]; other site 264462005857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462005858 dimer interface [polypeptide binding]; other site 264462005859 phosphorylation site [posttranslational modification] 264462005860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462005861 ATP binding site [chemical binding]; other site 264462005862 Mg2+ binding site [ion binding]; other site 264462005863 G-X-G motif; other site 264462005864 multiple promoter invertase; Provisional; Region: mpi; PRK13413 264462005865 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 264462005866 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 264462005867 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 264462005868 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 264462005869 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462005870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462005871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462005872 ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; Region: ABCC_MRP_domain1; cd03250 264462005873 Walker A/P-loop; other site 264462005874 ATP binding site [chemical binding]; other site 264462005875 Q-loop/lid; other site 264462005876 ABC transporter signature motif; other site 264462005877 Walker B; other site 264462005878 D-loop; other site 264462005879 H-loop/switch region; other site 264462005880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462005881 ATP-binding cassette domain 2 of NFT1, subfamily C; Region: ABCC_NFT1; cd03369 264462005882 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 264462005883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462005884 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264462005885 putative active site [active] 264462005886 heme pocket [chemical binding]; other site 264462005887 PAS fold; Region: PAS_4; pfam08448 264462005888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462005889 putative active site [active] 264462005890 heme pocket [chemical binding]; other site 264462005891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462005892 dimer interface [polypeptide binding]; other site 264462005893 phosphorylation site [posttranslational modification] 264462005894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462005895 ATP binding site [chemical binding]; other site 264462005896 Mg2+ binding site [ion binding]; other site 264462005897 G-X-G motif; other site 264462005898 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 264462005899 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 264462005900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462005901 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 264462005902 ligand binding site [chemical binding]; other site 264462005903 flexible hinge region; other site 264462005904 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264462005905 putative switch regulator; other site 264462005906 non-specific DNA interactions [nucleotide binding]; other site 264462005907 DNA binding site [nucleotide binding] 264462005908 sequence specific DNA binding site [nucleotide binding]; other site 264462005909 putative cAMP binding site [chemical binding]; other site 264462005910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462005911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462005912 ligand binding site [chemical binding]; other site 264462005913 flexible hinge region; other site 264462005914 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 264462005915 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826 264462005916 anaerobic ribonucleoside-triphosphate reductase; Region: RNR_anaer_Bdell; TIGR02827 264462005917 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 264462005918 NnrS protein; Region: NnrS; pfam05940 264462005919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462005920 dimer interface [polypeptide binding]; other site 264462005921 putative CheW interface [polypeptide binding]; other site 264462005922 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 264462005923 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264462005924 metal ion-dependent adhesion site (MIDAS); other site 264462005925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462005926 MoxR-like ATPases [General function prediction only]; Region: COG0714 264462005927 Walker A motif; other site 264462005928 ATP binding site [chemical binding]; other site 264462005929 Walker B motif; other site 264462005930 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 264462005931 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 264462005932 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264462005933 Cytochrome c; Region: Cytochrom_C; pfam00034 264462005934 Cytochrome c; Region: Cytochrom_C; pfam00034 264462005935 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462005936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462005937 ligand binding site [chemical binding]; other site 264462005938 flexible hinge region; other site 264462005939 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264462005940 putative switch regulator; other site 264462005941 non-specific DNA interactions [nucleotide binding]; other site 264462005942 DNA binding site [nucleotide binding] 264462005943 sequence specific DNA binding site [nucleotide binding]; other site 264462005944 putative cAMP binding site [chemical binding]; other site 264462005945 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 264462005946 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264462005947 Cu(I) binding site [ion binding]; other site 264462005948 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264462005949 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264462005950 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 264462005951 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 264462005952 Multicopper oxidase; Region: Cu-oxidase; pfam00394 264462005953 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264462005954 Cytochrome c; Region: Cytochrom_C; pfam00034 264462005955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264462005956 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264462005957 metal-binding site [ion binding] 264462005958 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264462005959 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264462005960 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 264462005961 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 264462005962 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 264462005963 Low-spin heme binding site [chemical binding]; other site 264462005964 Putative water exit pathway; other site 264462005965 Binuclear center (active site) [active] 264462005966 Putative proton exit pathway; other site 264462005967 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 264462005968 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 264462005969 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264462005970 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 264462005971 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264462005972 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264462005973 Family description; Region: DsbD_2; pfam13386 264462005974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462005975 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264462005976 ligand binding site [chemical binding]; other site 264462005977 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264462005978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462005979 S-adenosylmethionine binding site [chemical binding]; other site 264462005980 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 264462005981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462005982 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264462005983 dimerization interface [polypeptide binding]; other site 264462005984 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264462005985 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264462005986 dimerization interface [polypeptide binding]; other site 264462005987 DPS ferroxidase diiron center [ion binding]; other site 264462005988 ion pore; other site 264462005989 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 264462005990 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 264462005991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462005992 dimer interface [polypeptide binding]; other site 264462005993 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264462005994 putative CheW interface [polypeptide binding]; other site 264462005995 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 264462005996 hypothetical protein; Provisional; Region: PRK06762 264462005997 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462005998 KH domain; Region: KH_4; pfam13083 264462005999 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462006000 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 264462006001 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264462006002 iron-sulfur cluster [ion binding]; other site 264462006003 [2Fe-2S] cluster binding site [ion binding]; other site 264462006004 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264462006005 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264462006006 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 264462006007 cleavage site 264462006008 active site 264462006009 substrate binding sites [chemical binding]; other site 264462006010 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264462006011 Carboxylesterase family; Region: COesterase; pfam00135 264462006012 substrate binding pocket [chemical binding]; other site 264462006013 catalytic triad [active] 264462006014 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 264462006015 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264462006016 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 264462006017 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264462006018 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 264462006019 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264462006020 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264462006021 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264462006022 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 264462006023 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264462006024 cryptic adenine deaminase; Provisional; Region: PRK10027 264462006025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462006026 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 264462006027 active site 264462006028 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 264462006029 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 264462006030 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 264462006031 apolar tunnel; other site 264462006032 heme binding site [chemical binding]; other site 264462006033 dimerization interface [polypeptide binding]; other site 264462006034 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 264462006035 CHASE2 domain; Region: CHASE2; pfam05226 264462006036 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264462006037 cyclase homology domain; Region: CHD; cd07302 264462006038 nucleotidyl binding site; other site 264462006039 metal binding site [ion binding]; metal-binding site 264462006040 dimer interface [polypeptide binding]; other site 264462006041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006042 TPR repeat; Region: TPR_11; pfam13414 264462006043 binding surface 264462006044 TPR motif; other site 264462006045 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462006046 FecR protein; Region: FecR; pfam04773 264462006047 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462006048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462006049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462006050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462006051 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 264462006052 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 264462006053 ATP-binding site [chemical binding]; other site 264462006054 Sugar specificity; other site 264462006055 Pyrimidine base specificity; other site 264462006056 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264462006057 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264462006058 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264462006059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264462006060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264462006061 catalytic residue [active] 264462006062 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 264462006063 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264462006064 N-terminal plug; other site 264462006065 ligand-binding site [chemical binding]; other site 264462006066 META domain; Region: META; pfam03724 264462006067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462006068 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462006069 substrate binding pocket [chemical binding]; other site 264462006070 membrane-bound complex binding site; other site 264462006071 hinge residues; other site 264462006072 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 264462006073 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 264462006074 PhnA protein; Region: PhnA; pfam03831 264462006075 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 264462006076 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 264462006077 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 264462006078 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462006079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006080 active site 264462006081 phosphorylation site [posttranslational modification] 264462006082 intermolecular recognition site; other site 264462006083 dimerization interface [polypeptide binding]; other site 264462006084 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264462006085 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 264462006086 putative active site [active] 264462006087 putative FMN binding site [chemical binding]; other site 264462006088 putative substrate binding site [chemical binding]; other site 264462006089 putative catalytic residue [active] 264462006090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 264462006091 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 264462006092 FtsH Extracellular; Region: FtsH_ext; pfam06480 264462006093 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264462006094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006095 Walker A motif; other site 264462006096 ATP binding site [chemical binding]; other site 264462006097 Walker B motif; other site 264462006098 arginine finger; other site 264462006099 Peptidase family M41; Region: Peptidase_M41; pfam01434 264462006100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462006101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264462006102 NAD(P) binding site [chemical binding]; other site 264462006103 active site 264462006104 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264462006105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 264462006106 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 264462006107 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264462006108 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264462006109 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264462006110 AAA ATPase domain; Region: AAA_16; pfam13191 264462006111 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 264462006112 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 264462006113 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264462006114 active site 264462006115 catalytic residues [active] 264462006116 DNA binding site [nucleotide binding] 264462006117 Int/Topo IB signature motif; other site 264462006118 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 264462006119 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 264462006120 putative active site [active] 264462006121 putative NTP binding site [chemical binding]; other site 264462006122 putative nucleic acid binding site [nucleotide binding]; other site 264462006123 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 264462006124 HEAT repeats; Region: HEAT_2; pfam13646 264462006125 HEAT repeats; Region: HEAT_2; pfam13646 264462006126 dihydroorotase; Validated; Region: PRK09060 264462006127 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462006128 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 264462006129 active site 264462006130 Intracellular septation protein A; Region: IspA; cl01098 264462006131 enoyl-CoA hydratase; Provisional; Region: PRK09245 264462006132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264462006133 substrate binding site [chemical binding]; other site 264462006134 oxyanion hole (OAH) forming residues; other site 264462006135 trimer interface [polypeptide binding]; other site 264462006136 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462006137 catalytic triad [active] 264462006138 putative active site [active] 264462006139 Bacitracin resistance protein BacA; Region: BacA; pfam02673 264462006140 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264462006141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264462006142 hypothetical protein; Provisional; Region: PRK12472 264462006143 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264462006144 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264462006145 active site 264462006146 metal binding site [ion binding]; metal-binding site 264462006147 ribonuclease PH; Reviewed; Region: rph; PRK00173 264462006148 Ribonuclease PH; Region: RNase_PH_bact; cd11362 264462006149 hexamer interface [polypeptide binding]; other site 264462006150 active site 264462006151 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264462006152 active site 264462006153 dimerization interface [polypeptide binding]; other site 264462006154 GTPase RsgA; Reviewed; Region: PRK01889 264462006155 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264462006156 RNA binding site [nucleotide binding]; other site 264462006157 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264462006158 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264462006159 GTP/Mg2+ binding site [chemical binding]; other site 264462006160 G4 box; other site 264462006161 G5 box; other site 264462006162 G1 box; other site 264462006163 Switch I region; other site 264462006164 G2 box; other site 264462006165 G3 box; other site 264462006166 Switch II region; other site 264462006167 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264462006168 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264462006169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462006170 active site 264462006171 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 264462006172 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264462006173 5S rRNA interface [nucleotide binding]; other site 264462006174 CTC domain interface [polypeptide binding]; other site 264462006175 L16 interface [polypeptide binding]; other site 264462006176 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264462006177 putative active site [active] 264462006178 catalytic residue [active] 264462006179 GTP-binding protein YchF; Reviewed; Region: PRK09601 264462006180 YchF GTPase; Region: YchF; cd01900 264462006181 G1 box; other site 264462006182 GTP/Mg2+ binding site [chemical binding]; other site 264462006183 Switch I region; other site 264462006184 G2 box; other site 264462006185 Switch II region; other site 264462006186 G3 box; other site 264462006187 G4 box; other site 264462006188 G5 box; other site 264462006189 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264462006190 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264462006191 Amidase; Region: Amidase; pfam01425 264462006192 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 264462006193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462006194 dimer interface [polypeptide binding]; other site 264462006195 conserved gate region; other site 264462006196 putative PBP binding loops; other site 264462006197 ABC-ATPase subunit interface; other site 264462006198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264462006199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462006200 dimer interface [polypeptide binding]; other site 264462006201 conserved gate region; other site 264462006202 putative PBP binding loops; other site 264462006203 ABC-ATPase subunit interface; other site 264462006204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006205 binding surface 264462006206 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462006207 TPR motif; other site 264462006208 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462006209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462006210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462006211 catalytic residue [active] 264462006212 DNA repair protein RadA; Provisional; Region: PRK11823 264462006213 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264462006214 Walker A motif/ATP binding site; other site 264462006215 ATP binding site [chemical binding]; other site 264462006216 Walker B motif; other site 264462006217 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264462006218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462006219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462006220 ligand binding site [chemical binding]; other site 264462006221 flexible hinge region; other site 264462006222 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 264462006223 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264462006224 putative ligand binding site [chemical binding]; other site 264462006225 PilZ domain; Region: PilZ; pfam07238 264462006226 glycerol kinase; Provisional; Region: glpK; PRK00047 264462006227 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 264462006228 N- and C-terminal domain interface [polypeptide binding]; other site 264462006229 active site 264462006230 MgATP binding site [chemical binding]; other site 264462006231 catalytic site [active] 264462006232 metal binding site [ion binding]; metal-binding site 264462006233 glycerol binding site [chemical binding]; other site 264462006234 homotetramer interface [polypeptide binding]; other site 264462006235 homodimer interface [polypeptide binding]; other site 264462006236 FBP binding site [chemical binding]; other site 264462006237 protein IIAGlc interface [polypeptide binding]; other site 264462006238 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264462006239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 264462006240 putative acyl-acceptor binding pocket; other site 264462006241 imidazolonepropionase; Validated; Region: PRK09356 264462006242 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 264462006243 active site 264462006244 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264462006245 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264462006246 putative dimer interface [polypeptide binding]; other site 264462006247 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 264462006248 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264462006249 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264462006250 catalytic core [active] 264462006251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264462006252 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264462006253 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264462006254 TPP-binding site [chemical binding]; other site 264462006255 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 264462006256 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 264462006257 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264462006258 E3 interaction surface; other site 264462006259 lipoyl attachment site [posttranslational modification]; other site 264462006260 e3 binding domain; Region: E3_binding; pfam02817 264462006261 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264462006262 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 264462006263 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 264462006264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264462006265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264462006266 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 264462006267 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264462006268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264462006269 Walker A/P-loop; other site 264462006270 ATP binding site [chemical binding]; other site 264462006271 Q-loop/lid; other site 264462006272 ABC transporter signature motif; other site 264462006273 Walker B; other site 264462006274 D-loop; other site 264462006275 H-loop/switch region; other site 264462006276 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264462006277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462006278 putative PBP binding loops; other site 264462006279 dimer interface [polypeptide binding]; other site 264462006280 ABC-ATPase subunit interface; other site 264462006281 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264462006282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264462006283 urocanate hydratase; Provisional; Region: PRK05414 264462006284 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264462006285 active sites [active] 264462006286 tetramer interface [polypeptide binding]; other site 264462006287 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 264462006288 nudix motif; other site 264462006289 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 264462006290 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264462006291 substrate binding site [chemical binding]; other site 264462006292 hexamer interface [polypeptide binding]; other site 264462006293 metal binding site [ion binding]; metal-binding site 264462006294 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264462006295 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264462006296 putative active site [active] 264462006297 substrate binding site [chemical binding]; other site 264462006298 putative cosubstrate binding site; other site 264462006299 catalytic site [active] 264462006300 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264462006301 substrate binding site [chemical binding]; other site 264462006302 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264462006303 active site 264462006304 catalytic residues [active] 264462006305 metal binding site [ion binding]; metal-binding site 264462006306 Predicted permeases [General function prediction only]; Region: COG0795 264462006307 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264462006308 Response regulator receiver domain; Region: Response_reg; pfam00072 264462006309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006310 active site 264462006311 phosphorylation site [posttranslational modification] 264462006312 intermolecular recognition site; other site 264462006313 dimerization interface [polypeptide binding]; other site 264462006314 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 264462006315 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264462006316 dimerization interface [polypeptide binding]; other site 264462006317 active site 264462006318 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 264462006319 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 264462006320 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 264462006321 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462006322 putative catalytic residue [active] 264462006323 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 264462006324 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 264462006325 Uncharacterized conserved protein [Function unknown]; Region: COG2968 264462006326 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 264462006327 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264462006328 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462006329 ligand binding site [chemical binding]; other site 264462006330 KH domain; Region: KH_4; pfam13083 264462006331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 264462006332 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462006333 HD domain; Region: HD_3; cl17350 264462006334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462006335 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 264462006336 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 264462006337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462006338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462006339 substrate binding pocket [chemical binding]; other site 264462006340 membrane-bound complex binding site; other site 264462006341 hinge residues; other site 264462006342 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 264462006343 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264462006344 substrate binding site [chemical binding]; other site 264462006345 ligand binding site [chemical binding]; other site 264462006346 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 264462006347 substrate binding site [chemical binding]; other site 264462006348 NAD-dependent deacetylase; Provisional; Region: PRK00481 264462006349 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 264462006350 NAD+ binding site [chemical binding]; other site 264462006351 substrate binding site [chemical binding]; other site 264462006352 Zn binding site [ion binding]; other site 264462006353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462006354 salt bridge; other site 264462006355 non-specific DNA binding site [nucleotide binding]; other site 264462006356 sequence-specific DNA binding site [nucleotide binding]; other site 264462006357 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 264462006358 Oxygen tolerance; Region: BatD; pfam13584 264462006359 Oxygen tolerance; Region: BatD; pfam13584 264462006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006361 binding surface 264462006362 TPR motif; other site 264462006363 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462006364 von Willebrand factor type A domain; Region: VWA_2; pfam13519 264462006365 metal ion-dependent adhesion site (MIDAS); other site 264462006366 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 264462006367 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264462006368 metal ion-dependent adhesion site (MIDAS); other site 264462006369 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264462006370 Protein of unknown function DUF58; Region: DUF58; pfam01882 264462006371 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 264462006372 MoxR-like ATPases [General function prediction only]; Region: COG0714 264462006373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006374 Walker A motif; other site 264462006375 ATP binding site [chemical binding]; other site 264462006376 Walker B motif; other site 264462006377 arginine finger; other site 264462006378 Peptidase family M48; Region: Peptidase_M48; cl12018 264462006379 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 264462006380 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264462006381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264462006382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462006383 protein binding site [polypeptide binding]; other site 264462006384 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264462006385 protein binding site [polypeptide binding]; other site 264462006386 regulatory protein SpoVG; Reviewed; Region: PRK13259 264462006387 TPR repeat; Region: TPR_11; pfam13414 264462006388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006389 TPR motif; other site 264462006390 binding surface 264462006391 TPR repeat; Region: TPR_11; pfam13414 264462006392 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462006393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006394 binding surface 264462006395 TPR motif; other site 264462006396 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 264462006397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462006398 motif II; other site 264462006399 Predicted membrane protein [Function unknown]; Region: COG4270 264462006400 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264462006401 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 264462006402 putative NAD(P) binding site [chemical binding]; other site 264462006403 catalytic Zn binding site [ion binding]; other site 264462006404 structural Zn binding site [ion binding]; other site 264462006405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462006406 S-adenosylmethionine binding site [chemical binding]; other site 264462006407 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264462006408 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 264462006409 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264462006410 active site 264462006411 catalytic site [active] 264462006412 metal binding site [ion binding]; metal-binding site 264462006413 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462006414 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462006415 active site 264462006416 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 264462006417 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 264462006418 Cytochrome c552; Region: Cytochrom_C552; pfam02335 264462006419 ResB-like family; Region: ResB; pfam05140 264462006420 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264462006421 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264462006422 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264462006423 CheD chemotactic sensory transduction; Region: CheD; cl00810 264462006424 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264462006425 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264462006426 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264462006427 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264462006428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462006429 putative active site [active] 264462006430 heme pocket [chemical binding]; other site 264462006431 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264462006432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462006433 putative active site [active] 264462006434 heme pocket [chemical binding]; other site 264462006435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462006436 putative active site [active] 264462006437 heme pocket [chemical binding]; other site 264462006438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462006439 dimerization interface [polypeptide binding]; other site 264462006440 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462006441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462006442 dimer interface [polypeptide binding]; other site 264462006443 putative CheW interface [polypeptide binding]; other site 264462006444 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 264462006445 active site 264462006446 catalytic residues [active] 264462006447 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 264462006448 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 264462006449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462006450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006451 ATP binding site [chemical binding]; other site 264462006452 Mg2+ binding site [ion binding]; other site 264462006453 G-X-G motif; other site 264462006454 malate dehydrogenase; Provisional; Region: PRK13529 264462006455 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264462006456 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 264462006457 NAD(P) binding site [chemical binding]; other site 264462006458 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 264462006459 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264462006460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462006461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006462 active site 264462006463 phosphorylation site [posttranslational modification] 264462006464 intermolecular recognition site; other site 264462006465 dimerization interface [polypeptide binding]; other site 264462006466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264462006467 DNA binding residues [nucleotide binding] 264462006468 dimerization interface [polypeptide binding]; other site 264462006469 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462006470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462006471 putative active site [active] 264462006472 heme pocket [chemical binding]; other site 264462006473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006474 ATP binding site [chemical binding]; other site 264462006475 Mg2+ binding site [ion binding]; other site 264462006476 G-X-G motif; other site 264462006477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 264462006478 GAF domain; Region: GAF; pfam01590 264462006479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462006480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462006481 dimer interface [polypeptide binding]; other site 264462006482 phosphorylation site [posttranslational modification] 264462006483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006484 ATP binding site [chemical binding]; other site 264462006485 Mg2+ binding site [ion binding]; other site 264462006486 G-X-G motif; other site 264462006487 Response regulator receiver domain; Region: Response_reg; pfam00072 264462006488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006489 active site 264462006490 phosphorylation site [posttranslational modification] 264462006491 intermolecular recognition site; other site 264462006492 dimerization interface [polypeptide binding]; other site 264462006493 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 264462006494 putative deacylase active site [active] 264462006495 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264462006496 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264462006497 putative active site [active] 264462006498 putative metal binding site [ion binding]; other site 264462006499 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 264462006500 Transglycosylase; Region: Transgly; cl17702 264462006501 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 264462006502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462006503 dimer interface [polypeptide binding]; other site 264462006504 active site 264462006505 metal binding site [ion binding]; metal-binding site 264462006506 glutathione binding site [chemical binding]; other site 264462006507 MASE1; Region: MASE1; pfam05231 264462006508 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 264462006509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462006510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462006511 dimer interface [polypeptide binding]; other site 264462006512 phosphorylation site [posttranslational modification] 264462006513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006514 ATP binding site [chemical binding]; other site 264462006515 Mg2+ binding site [ion binding]; other site 264462006516 G-X-G motif; other site 264462006517 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462006518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006519 active site 264462006520 phosphorylation site [posttranslational modification] 264462006521 intermolecular recognition site; other site 264462006522 dimerization interface [polypeptide binding]; other site 264462006523 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 264462006524 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 264462006525 hypothetical protein; Reviewed; Region: PRK09588 264462006526 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 264462006527 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462006528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462006529 substrate binding pocket [chemical binding]; other site 264462006530 membrane-bound complex binding site; other site 264462006531 hinge residues; other site 264462006532 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264462006533 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 264462006534 Aspartase; Region: Aspartase; cd01357 264462006535 active sites [active] 264462006536 tetramer interface [polypeptide binding]; other site 264462006537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264462006538 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 264462006539 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264462006540 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264462006541 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264462006542 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264462006543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462006544 S-adenosylmethionine binding site [chemical binding]; other site 264462006545 DNA topoisomerase VI subunit A; Provisional; Region: PRK04342 264462006546 Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406 264462006547 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 264462006548 active site 264462006549 metal binding site [ion binding]; metal-binding site 264462006550 interdomain interaction site; other site 264462006551 DNA topoisomerase VI subunit B; Validated; Region: PRK04184 264462006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006553 ATP binding site [chemical binding]; other site 264462006554 Mg2+ binding site [ion binding]; other site 264462006555 G-X-G motif; other site 264462006556 TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823 264462006557 anchoring element; other site 264462006558 dimer interface [polypeptide binding]; other site 264462006559 ATP binding site [chemical binding]; other site 264462006560 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 264462006561 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264462006562 Trp docking motif [polypeptide binding]; other site 264462006563 active site 264462006564 PQQ-like domain; Region: PQQ_2; pfam13360 264462006565 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264462006566 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 264462006567 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 264462006568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264462006569 substrate binding pocket [chemical binding]; other site 264462006570 membrane-bound complex binding site; other site 264462006571 hinge residues; other site 264462006572 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 264462006573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 264462006574 active site 264462006575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462006576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462006577 ligand binding site [chemical binding]; other site 264462006578 flexible hinge region; other site 264462006579 PilZ domain; Region: PilZ; pfam07238 264462006580 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 264462006581 FOG: CBS domain [General function prediction only]; Region: COG0517 264462006582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264462006583 Sulfatase; Region: Sulfatase; pfam00884 264462006584 BolA-like protein; Region: BolA; pfam01722 264462006585 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 264462006586 putative GSH binding site [chemical binding]; other site 264462006587 catalytic residues [active] 264462006588 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264462006589 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264462006590 FAD binding domain; Region: FAD_binding_4; pfam01565 264462006591 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462006592 Interdomain contacts; other site 264462006593 Fibronectin type 3 domain; Region: FN3; smart00060 264462006594 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462006595 Interdomain contacts; other site 264462006596 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462006597 Interdomain contacts; other site 264462006598 Cytokine receptor motif; other site 264462006599 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 264462006600 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 264462006601 ligand binding site [chemical binding]; other site 264462006602 NAD binding site [chemical binding]; other site 264462006603 tetramer interface [polypeptide binding]; other site 264462006604 catalytic site [active] 264462006605 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 264462006606 L-serine binding site [chemical binding]; other site 264462006607 ACT domain interface; other site 264462006608 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462006609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006610 active site 264462006611 phosphorylation site [posttranslational modification] 264462006612 intermolecular recognition site; other site 264462006613 dimerization interface [polypeptide binding]; other site 264462006614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006615 Walker A motif; other site 264462006616 ATP binding site [chemical binding]; other site 264462006617 Walker B motif; other site 264462006618 arginine finger; other site 264462006619 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264462006620 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 264462006621 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264462006622 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264462006623 putative acyl-acceptor binding pocket; other site 264462006624 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264462006625 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 264462006626 Flavodoxin domain; Region: Flavodoxin_5; cl17428 264462006627 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 264462006628 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 264462006629 metal binding site [ion binding]; metal-binding site 264462006630 dimer interface [polypeptide binding]; other site 264462006631 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 264462006632 PKC phosphorylation site [posttranslational modification]; other site 264462006633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462006634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462006635 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264462006636 putative effector binding pocket; other site 264462006637 dimerization interface [polypeptide binding]; other site 264462006638 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264462006639 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 264462006640 NADP binding site [chemical binding]; other site 264462006641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264462006642 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264462006643 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462006644 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 264462006645 LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins; Region: LEM; cl02649 264462006646 polypeptide substrate binding site [polypeptide binding]; other site 264462006647 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 264462006648 Walker A/P-loop; other site 264462006649 ATP binding site [chemical binding]; other site 264462006650 Q-loop/lid; other site 264462006651 ABC transporter signature motif; other site 264462006652 Walker B; other site 264462006653 D-loop; other site 264462006654 H-loop/switch region; other site 264462006655 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 264462006656 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 264462006657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462006658 putative substrate translocation pore; other site 264462006659 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264462006660 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264462006661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264462006662 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 264462006663 dimerization interface [polypeptide binding]; other site 264462006664 putative active cleft [active] 264462006665 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 264462006666 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 264462006667 catalytic triad [active] 264462006668 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264462006669 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462006670 active site 264462006671 substrate binding sites [chemical binding]; other site 264462006672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264462006673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264462006674 active site 264462006675 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 264462006676 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 264462006677 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 264462006678 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 264462006679 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 264462006680 Substrate binding site; other site 264462006681 Cupin domain; Region: Cupin_2; cl17218 264462006682 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264462006683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462006684 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 264462006685 active site 264462006686 motif I; other site 264462006687 motif II; other site 264462006688 TIGR03546 family protein; Region: TIGR03546 264462006689 TIGR03545 family protein; Region: TIGR03545 264462006690 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264462006691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264462006692 catalytic residues [active] 264462006693 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264462006694 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264462006695 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264462006696 alphaNTD homodimer interface [polypeptide binding]; other site 264462006697 alphaNTD - beta interaction site [polypeptide binding]; other site 264462006698 alphaNTD - beta' interaction site [polypeptide binding]; other site 264462006699 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264462006700 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264462006701 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264462006702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462006703 RNA binding surface [nucleotide binding]; other site 264462006704 30S ribosomal protein S11; Validated; Region: PRK05309 264462006705 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264462006706 30S ribosomal protein S13; Region: bact_S13; TIGR03631 264462006707 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 264462006708 adenylate kinase; Reviewed; Region: adk; PRK00279 264462006709 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264462006710 AMP-binding site [chemical binding]; other site 264462006711 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264462006712 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264462006713 SecY translocase; Region: SecY; pfam00344 264462006714 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264462006715 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264462006716 23S rRNA binding site [nucleotide binding]; other site 264462006717 ribosomal protein S5; Validated; Region: rps5; CHL00138 264462006718 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264462006719 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264462006720 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264462006721 23S rRNA interface [nucleotide binding]; other site 264462006722 L21e interface [polypeptide binding]; other site 264462006723 5S rRNA interface [nucleotide binding]; other site 264462006724 L27 interface [polypeptide binding]; other site 264462006725 L5 interface [polypeptide binding]; other site 264462006726 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264462006727 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264462006728 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264462006729 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264462006730 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264462006731 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264462006732 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264462006733 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264462006734 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264462006735 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264462006736 putative translocon interaction site; other site 264462006737 23S rRNA interface [nucleotide binding]; other site 264462006738 signal recognition particle (SRP54) interaction site; other site 264462006739 L23 interface [polypeptide binding]; other site 264462006740 trigger factor interaction site; other site 264462006741 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264462006742 23S rRNA interface [nucleotide binding]; other site 264462006743 5S rRNA interface [nucleotide binding]; other site 264462006744 putative antibiotic binding site [chemical binding]; other site 264462006745 L25 interface [polypeptide binding]; other site 264462006746 L27 interface [polypeptide binding]; other site 264462006747 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264462006748 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264462006749 G-X-X-G motif; other site 264462006750 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264462006751 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264462006752 putative translocon binding site; other site 264462006753 protein-rRNA interface [nucleotide binding]; other site 264462006754 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264462006755 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264462006756 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264462006757 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264462006758 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264462006759 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264462006760 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 264462006761 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264462006762 elongation factor G; Reviewed; Region: PRK00007 264462006763 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264462006764 G1 box; other site 264462006765 putative GEF interaction site [polypeptide binding]; other site 264462006766 GTP/Mg2+ binding site [chemical binding]; other site 264462006767 Switch I region; other site 264462006768 G2 box; other site 264462006769 G3 box; other site 264462006770 Switch II region; other site 264462006771 G4 box; other site 264462006772 G5 box; other site 264462006773 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264462006774 Elongation factor G, domain IV; Region: EFG_IV; smart00889 264462006775 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264462006776 30S ribosomal protein S7; Validated; Region: PRK05302 264462006777 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264462006778 S17 interaction site [polypeptide binding]; other site 264462006779 S8 interaction site; other site 264462006780 16S rRNA interaction site [nucleotide binding]; other site 264462006781 streptomycin interaction site [chemical binding]; other site 264462006782 23S rRNA interaction site [nucleotide binding]; other site 264462006783 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264462006784 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264462006785 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264462006786 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 264462006787 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264462006788 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264462006789 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 264462006790 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264462006791 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264462006792 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264462006793 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264462006794 DNA binding site [nucleotide binding] 264462006795 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264462006796 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 264462006797 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264462006798 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264462006799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264462006800 RPB12 interaction site [polypeptide binding]; other site 264462006801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264462006802 RPB11 interaction site [polypeptide binding]; other site 264462006803 RPB12 interaction site [polypeptide binding]; other site 264462006804 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264462006805 RPB3 interaction site [polypeptide binding]; other site 264462006806 RPB1 interaction site [polypeptide binding]; other site 264462006807 RPB11 interaction site [polypeptide binding]; other site 264462006808 RPB10 interaction site [polypeptide binding]; other site 264462006809 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264462006810 core dimer interface [polypeptide binding]; other site 264462006811 peripheral dimer interface [polypeptide binding]; other site 264462006812 L10 interface [polypeptide binding]; other site 264462006813 L11 interface [polypeptide binding]; other site 264462006814 putative EF-Tu interaction site [polypeptide binding]; other site 264462006815 putative EF-G interaction site [polypeptide binding]; other site 264462006816 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264462006817 23S rRNA interface [nucleotide binding]; other site 264462006818 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264462006819 mRNA/rRNA interface [nucleotide binding]; other site 264462006820 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264462006821 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264462006822 23S rRNA interface [nucleotide binding]; other site 264462006823 L7/L12 interface [polypeptide binding]; other site 264462006824 putative thiostrepton binding site; other site 264462006825 L25 interface [polypeptide binding]; other site 264462006826 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264462006827 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264462006828 putative homodimer interface [polypeptide binding]; other site 264462006829 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264462006830 heterodimer interface [polypeptide binding]; other site 264462006831 homodimer interface [polypeptide binding]; other site 264462006832 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 264462006833 elongation factor Tu; Reviewed; Region: PRK00049 264462006834 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264462006835 G1 box; other site 264462006836 GEF interaction site [polypeptide binding]; other site 264462006837 GTP/Mg2+ binding site [chemical binding]; other site 264462006838 Switch I region; other site 264462006839 G2 box; other site 264462006840 G3 box; other site 264462006841 Switch II region; other site 264462006842 G4 box; other site 264462006843 G5 box; other site 264462006844 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264462006845 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264462006846 Antibiotic Binding Site [chemical binding]; other site 264462006847 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264462006848 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 264462006849 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264462006850 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 264462006851 active site 264462006852 dimer interface [polypeptide binding]; other site 264462006853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264462006854 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264462006855 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264462006856 dimerization interface [polypeptide binding]; other site 264462006857 putative ATP binding site [chemical binding]; other site 264462006858 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264462006859 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264462006860 purine monophosphate binding site [chemical binding]; other site 264462006861 dimer interface [polypeptide binding]; other site 264462006862 putative catalytic residues [active] 264462006863 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 264462006864 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264462006865 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 264462006866 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264462006867 conserved cys residue [active] 264462006868 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 264462006869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264462006870 dimerization interface [polypeptide binding]; other site 264462006871 ATP binding site [chemical binding]; other site 264462006872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264462006873 dimerization interface [polypeptide binding]; other site 264462006874 ATP binding site [chemical binding]; other site 264462006875 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 264462006876 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264462006877 active site 264462006878 substrate binding site [chemical binding]; other site 264462006879 cosubstrate binding site; other site 264462006880 catalytic site [active] 264462006881 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264462006882 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264462006883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264462006884 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264462006885 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 264462006886 ATP binding site [chemical binding]; other site 264462006887 active site 264462006888 substrate binding site [chemical binding]; other site 264462006889 AIR carboxylase; Region: AIRC; cl00310 264462006890 amidophosphoribosyltransferase; Provisional; Region: PRK09246 264462006891 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264462006892 active site 264462006893 tetramer interface [polypeptide binding]; other site 264462006894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462006895 active site 264462006896 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 264462006897 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462006898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462006899 dimerization interface [polypeptide binding]; other site 264462006900 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 264462006901 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264462006902 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 264462006903 FliG C-terminal domain; Region: FliG_C; pfam01706 264462006904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462006905 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462006906 TPR motif; other site 264462006907 binding surface 264462006908 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264462006909 flagellar motor protein MotS; Reviewed; Region: PRK06925 264462006910 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264462006911 ligand binding site [chemical binding]; other site 264462006912 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264462006913 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264462006914 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264462006915 metal ion-dependent adhesion site (MIDAS); other site 264462006916 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264462006917 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462006918 FG-GAP repeat; Region: FG-GAP; cl15299 264462006919 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 264462006920 Family description; Region: VCBS; pfam13517 264462006921 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 264462006922 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 264462006923 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462006924 Interdomain contacts; other site 264462006925 Cytokine receptor motif; other site 264462006926 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 264462006927 Phage-related protein, tail component [Function unknown]; Region: COG4733 264462006928 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264462006929 KH domain; Region: KH_4; pfam13083 264462006930 prolyl-tRNA synthetase; Provisional; Region: PRK08661 264462006931 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 264462006932 dimer interface [polypeptide binding]; other site 264462006933 motif 1; other site 264462006934 active site 264462006935 motif 2; other site 264462006936 motif 3; other site 264462006937 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 264462006938 anticodon binding site; other site 264462006939 zinc-binding site [ion binding]; other site 264462006940 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462006941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462006942 active site 264462006943 phosphorylation site [posttranslational modification] 264462006944 intermolecular recognition site; other site 264462006945 dimerization interface [polypeptide binding]; other site 264462006946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006947 Walker A motif; other site 264462006948 ATP binding site [chemical binding]; other site 264462006949 Walker B motif; other site 264462006950 arginine finger; other site 264462006951 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462006952 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 264462006953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462006954 dimerization interface [polypeptide binding]; other site 264462006955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462006956 putative active site [active] 264462006957 heme pocket [chemical binding]; other site 264462006958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462006959 dimer interface [polypeptide binding]; other site 264462006960 phosphorylation site [posttranslational modification] 264462006961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462006962 ATP binding site [chemical binding]; other site 264462006963 Mg2+ binding site [ion binding]; other site 264462006964 G-X-G motif; other site 264462006965 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264462006966 homopentamer interface [polypeptide binding]; other site 264462006967 active site 264462006968 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264462006969 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264462006970 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 264462006971 dimerization interface [polypeptide binding]; other site 264462006972 active site 264462006973 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264462006974 Lumazine binding domain; Region: Lum_binding; pfam00677 264462006975 Lumazine binding domain; Region: Lum_binding; pfam00677 264462006976 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 264462006977 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264462006978 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264462006979 putative active site [active] 264462006980 putative metal binding site [ion binding]; other site 264462006981 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 264462006982 active site 264462006983 dimer interfaces [polypeptide binding]; other site 264462006984 catalytic residues [active] 264462006985 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264462006986 Clp amino terminal domain; Region: Clp_N; pfam02861 264462006987 Clp amino terminal domain; Region: Clp_N; pfam02861 264462006988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006989 Walker A motif; other site 264462006990 ATP binding site [chemical binding]; other site 264462006991 Walker B motif; other site 264462006992 arginine finger; other site 264462006993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462006994 Walker A motif; other site 264462006995 ATP binding site [chemical binding]; other site 264462006996 Walker B motif; other site 264462006997 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264462006998 flagellin; Provisional; Region: PRK12802 264462006999 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462007000 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462007001 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264462007002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264462007004 active site 264462007005 phosphorylation site [posttranslational modification] 264462007006 intermolecular recognition site; other site 264462007007 dimerization interface [polypeptide binding]; other site 264462007008 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462007009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462007010 ligand binding site [chemical binding]; other site 264462007011 flexible hinge region; other site 264462007012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264462007013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264462007014 putative DNA binding site [nucleotide binding]; other site 264462007015 putative Zn2+ binding site [ion binding]; other site 264462007016 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264462007017 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264462007018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462007019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462007020 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264462007021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462007022 Walker A motif; other site 264462007023 ATP binding site [chemical binding]; other site 264462007024 Walker B motif; other site 264462007025 arginine finger; other site 264462007026 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462007027 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264462007028 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264462007029 active site 264462007030 DNA binding site [nucleotide binding] 264462007031 Int/Topo IB signature motif; other site 264462007032 Recombination protein O N terminal; Region: RecO_N; pfam11967 264462007033 Recombination protein O C terminal; Region: RecO_C; pfam02565 264462007034 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 264462007035 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264462007036 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264462007037 Di-iron ligands [ion binding]; other site 264462007038 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 264462007039 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 264462007040 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 264462007041 Methyltransferase domain; Region: Methyltransf_25; pfam13649 264462007042 S-adenosylmethionine binding site [chemical binding]; other site 264462007043 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 264462007044 cyclase homology domain; Region: CHD; cd07302 264462007045 nucleotidyl binding site; other site 264462007046 metal binding site [ion binding]; metal-binding site 264462007047 dimer interface [polypeptide binding]; other site 264462007048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462007049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462007050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264462007051 dimerization interface [polypeptide binding]; other site 264462007052 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 264462007053 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 264462007054 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264462007055 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264462007056 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 264462007057 4Fe-4S binding domain; Region: Fer4; pfam00037 264462007058 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 264462007059 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264462007060 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264462007061 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264462007062 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264462007063 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264462007064 SLBB domain; Region: SLBB; pfam10531 264462007065 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 264462007066 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264462007067 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264462007068 putative dimer interface [polypeptide binding]; other site 264462007069 [2Fe-2S] cluster binding site [ion binding]; other site 264462007070 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 264462007071 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 264462007072 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 264462007073 NADH dehydrogenase subunit D; Validated; Region: PRK06075 264462007074 NADH dehydrogenase subunit B; Validated; Region: PRK06411 264462007075 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462007076 catalytic triad [active] 264462007077 putative active site [active] 264462007078 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264462007079 hypothetical protein; Provisional; Region: PRK05409 264462007080 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 264462007081 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264462007082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462007083 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462007084 dimer interface [polypeptide binding]; other site 264462007085 putative CheW interface [polypeptide binding]; other site 264462007086 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 264462007087 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264462007088 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264462007089 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264462007090 dinuclear metal binding motif [ion binding]; other site 264462007091 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264462007092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264462007093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264462007094 Walker A/P-loop; other site 264462007095 ATP binding site [chemical binding]; other site 264462007096 Q-loop/lid; other site 264462007097 ABC transporter signature motif; other site 264462007098 Walker B; other site 264462007099 D-loop; other site 264462007100 H-loop/switch region; other site 264462007101 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264462007102 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264462007103 PilZ domain; Region: PilZ; pfam07238 264462007104 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462007105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007106 active site 264462007107 phosphorylation site [posttranslational modification] 264462007108 intermolecular recognition site; other site 264462007109 dimerization interface [polypeptide binding]; other site 264462007110 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 264462007111 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 264462007112 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264462007113 active site 264462007114 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264462007115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264462007116 dimer interface [polypeptide binding]; other site 264462007117 conserved gate region; other site 264462007118 ABC-ATPase subunit interface; other site 264462007119 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 264462007120 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 264462007121 Walker A/P-loop; other site 264462007122 ATP binding site [chemical binding]; other site 264462007123 Q-loop/lid; other site 264462007124 ABC transporter signature motif; other site 264462007125 Walker B; other site 264462007126 D-loop; other site 264462007127 H-loop/switch region; other site 264462007128 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 264462007129 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462007130 substrate binding pocket [chemical binding]; other site 264462007131 membrane-bound complex binding site; other site 264462007132 hinge residues; other site 264462007133 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 264462007134 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264462007135 putative SAM binding site [chemical binding]; other site 264462007136 putative homodimer interface [polypeptide binding]; other site 264462007137 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 264462007138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462007139 ATP binding site [chemical binding]; other site 264462007140 putative Mg++ binding site [ion binding]; other site 264462007141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462007142 nucleotide binding region [chemical binding]; other site 264462007143 ATP-binding site [chemical binding]; other site 264462007144 Helicase associated domain (HA2); Region: HA2; pfam04408 264462007145 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 264462007146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264462007147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264462007148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462007149 RNA binding surface [nucleotide binding]; other site 264462007150 serine O-acetyltransferase; Region: cysE; TIGR01172 264462007151 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264462007152 trimer interface [polypeptide binding]; other site 264462007153 active site 264462007154 substrate binding site [chemical binding]; other site 264462007155 CoA binding site [chemical binding]; other site 264462007156 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 264462007157 generic binding surface II; other site 264462007158 generic binding surface I; other site 264462007159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264462007160 Zn2+ binding site [ion binding]; other site 264462007161 Mg2+ binding site [ion binding]; other site 264462007162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462007163 binding surface 264462007164 TPR motif; other site 264462007165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462007166 binding surface 264462007167 TPR repeat; Region: TPR_11; pfam13414 264462007168 TPR motif; other site 264462007169 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 264462007170 mce related protein; Region: MCE; pfam02470 264462007171 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264462007172 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264462007173 Walker A/P-loop; other site 264462007174 ATP binding site [chemical binding]; other site 264462007175 Q-loop/lid; other site 264462007176 ABC transporter signature motif; other site 264462007177 Walker B; other site 264462007178 D-loop; other site 264462007179 H-loop/switch region; other site 264462007180 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264462007181 Permease; Region: Permease; pfam02405 264462007182 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 264462007183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264462007184 active site 264462007185 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264462007186 dimer interface [polypeptide binding]; other site 264462007187 substrate binding site [chemical binding]; other site 264462007188 catalytic residues [active] 264462007189 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 264462007190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264462007191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264462007192 metal binding site [ion binding]; metal-binding site 264462007193 active site 264462007194 I-site; other site 264462007195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007197 dimer interface [polypeptide binding]; other site 264462007198 phosphorylation site [posttranslational modification] 264462007199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007200 ATP binding site [chemical binding]; other site 264462007201 Mg2+ binding site [ion binding]; other site 264462007202 G-X-G motif; other site 264462007203 L-aspartate oxidase; Provisional; Region: PRK09077 264462007204 L-aspartate oxidase; Provisional; Region: PRK06175 264462007205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264462007206 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264462007207 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462007208 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264462007209 classical (c) SDRs; Region: SDR_c; cd05233 264462007210 NAD(P) binding site [chemical binding]; other site 264462007211 active site 264462007212 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264462007213 RNA/DNA hybrid binding site [nucleotide binding]; other site 264462007214 active site 264462007215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264462007216 dimerization interface [polypeptide binding]; other site 264462007217 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 264462007218 oligomer interface [polypeptide binding]; other site 264462007219 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 264462007220 active site 264462007221 PilZ domain; Region: PilZ; pfam07238 264462007222 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 264462007223 Family description; Region: UvrD_C_2; pfam13538 264462007224 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264462007225 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264462007226 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264462007227 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264462007228 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264462007229 CoA-binding site [chemical binding]; other site 264462007230 ATP-binding [chemical binding]; other site 264462007231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264462007232 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264462007233 active site 264462007234 ATP binding site [chemical binding]; other site 264462007235 substrate binding site [chemical binding]; other site 264462007236 activation loop (A-loop); other site 264462007237 PEGA domain; Region: PEGA; pfam08308 264462007238 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 264462007239 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 264462007240 acyl-activating enzyme (AAE) consensus motif; other site 264462007241 putative AMP binding site [chemical binding]; other site 264462007242 putative active site [active] 264462007243 putative CoA binding site [chemical binding]; other site 264462007244 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 264462007245 active site 264462007246 cosubstrate binding site; other site 264462007247 substrate binding site [chemical binding]; other site 264462007248 catalytic site [active] 264462007249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264462007250 peptide synthase; Provisional; Region: PRK09274 264462007251 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 264462007252 acyl-activating enzyme (AAE) consensus motif; other site 264462007253 putative AMP binding site [chemical binding]; other site 264462007254 putative active site [active] 264462007255 putative CoA binding site [chemical binding]; other site 264462007256 phosphoenolpyruvate synthase; Validated; Region: PRK06241 264462007257 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264462007258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264462007259 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 264462007260 Predicted dehydrogenase [General function prediction only]; Region: COG5322 264462007261 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 264462007262 NAD(P) binding pocket [chemical binding]; other site 264462007263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264462007264 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 264462007265 putative NAD(P) binding site [chemical binding]; other site 264462007266 active site 264462007267 putative substrate binding site [chemical binding]; other site 264462007268 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 264462007269 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 264462007270 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 264462007271 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264462007272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462007273 FtsX-like permease family; Region: FtsX; pfam02687 264462007274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462007275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462007276 Walker A/P-loop; other site 264462007277 ATP binding site [chemical binding]; other site 264462007278 Q-loop/lid; other site 264462007279 ABC transporter signature motif; other site 264462007280 Walker B; other site 264462007281 D-loop; other site 264462007282 H-loop/switch region; other site 264462007283 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264462007284 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264462007285 active site 264462007286 Zn binding site [ion binding]; other site 264462007287 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 264462007288 ATP-NAD kinase; Region: NAD_kinase; pfam01513 264462007289 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264462007290 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264462007291 Walker A/P-loop; other site 264462007292 ATP binding site [chemical binding]; other site 264462007293 Q-loop/lid; other site 264462007294 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264462007295 Q-loop/lid; other site 264462007296 ABC transporter signature motif; other site 264462007297 Walker B; other site 264462007298 D-loop; other site 264462007299 H-loop/switch region; other site 264462007300 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 264462007301 NmrA-like family; Region: NmrA; pfam05368 264462007302 putative NADP binding site [chemical binding]; other site 264462007303 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 264462007304 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462007305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462007306 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462007307 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462007308 dimer interface [polypeptide binding]; other site 264462007309 putative CheW interface [polypeptide binding]; other site 264462007310 aconitate hydratase; Validated; Region: PRK09277 264462007311 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264462007312 substrate binding site [chemical binding]; other site 264462007313 ligand binding site [chemical binding]; other site 264462007314 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264462007315 substrate binding site [chemical binding]; other site 264462007316 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264462007317 dimer interface [polypeptide binding]; other site 264462007318 ADP-ribose binding site [chemical binding]; other site 264462007319 active site 264462007320 nudix motif; other site 264462007321 metal binding site [ion binding]; metal-binding site 264462007322 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462007323 PA14 domain; Region: PA14; cl08459 264462007324 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462007325 Interdomain contacts; other site 264462007326 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 264462007327 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462007328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462007329 S-adenosylmethionine binding site [chemical binding]; other site 264462007330 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264462007331 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264462007332 putative active site [active] 264462007333 putative metal binding site [ion binding]; other site 264462007334 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264462007335 cell division protein FtsZ; Validated; Region: PRK09330 264462007336 nucleotide binding site [chemical binding]; other site 264462007337 SulA interaction site; other site 264462007338 cell division protein FtsA; Region: ftsA; TIGR01174 264462007339 Cell division protein FtsA; Region: FtsA; smart00842 264462007340 Cell division protein FtsA; Region: FtsA; pfam14450 264462007341 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 264462007342 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264462007343 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 264462007344 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 264462007345 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462007346 dimer interface [polypeptide binding]; other site 264462007347 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264462007348 putative CheW interface [polypeptide binding]; other site 264462007349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462007350 Ligand Binding Site [chemical binding]; other site 264462007351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462007352 Ligand Binding Site [chemical binding]; other site 264462007353 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264462007354 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 264462007355 dimerization interface [polypeptide binding]; other site 264462007356 ligand binding site [chemical binding]; other site 264462007357 NADP binding site [chemical binding]; other site 264462007358 catalytic site [active] 264462007359 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264462007360 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264462007361 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462007362 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462007363 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264462007364 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264462007365 homodimer interface [polypeptide binding]; other site 264462007366 active site 264462007367 cell division protein FtsW; Region: ftsW; TIGR02614 264462007368 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 264462007369 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 264462007370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462007371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462007372 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264462007373 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264462007374 Mg++ binding site [ion binding]; other site 264462007375 putative catalytic motif [active] 264462007376 putative substrate binding site [chemical binding]; other site 264462007377 FOG: CBS domain [General function prediction only]; Region: COG0517 264462007378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264462007379 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264462007380 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264462007381 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462007382 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462007383 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264462007384 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264462007385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264462007386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264462007387 Predicted esterase [General function prediction only]; Region: COG0400 264462007388 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462007389 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462007390 ligand binding site [chemical binding]; other site 264462007391 flexible hinge region; other site 264462007392 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264462007393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264462007394 putative active site [active] 264462007395 putative metal binding site [ion binding]; other site 264462007396 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264462007397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462007398 ATP binding site [chemical binding]; other site 264462007399 putative Mg++ binding site [ion binding]; other site 264462007400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462007401 nucleotide binding region [chemical binding]; other site 264462007402 ATP-binding site [chemical binding]; other site 264462007403 HRDC domain; Region: HRDC; pfam00570 264462007404 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 264462007405 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264462007406 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264462007407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264462007408 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 264462007409 MraW methylase family; Region: Methyltransf_5; cl17771 264462007410 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264462007411 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264462007412 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462007413 active site 264462007414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462007415 active site 264462007416 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462007417 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462007418 Predicted membrane protein [Function unknown]; Region: COG2119 264462007419 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264462007420 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264462007421 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 264462007422 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264462007423 Cu(I) binding site [ion binding]; other site 264462007424 Protein of unknown function (DUF461); Region: DUF461; pfam04314 264462007425 Pirin-related protein [General function prediction only]; Region: COG1741 264462007426 Pirin; Region: Pirin; pfam02678 264462007427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462007428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462007429 dimerization interface [polypeptide binding]; other site 264462007430 thymidylate synthase; Reviewed; Region: thyA; PRK01827 264462007431 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264462007432 dimerization interface [polypeptide binding]; other site 264462007433 active site 264462007434 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264462007435 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264462007436 folate binding site [chemical binding]; other site 264462007437 NADP+ binding site [chemical binding]; other site 264462007438 PilZ domain; Region: PilZ; pfam07238 264462007439 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 264462007440 FAD binding domain; Region: FAD_binding_4; pfam01565 264462007441 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264462007442 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 264462007443 putative active site [active] 264462007444 Zn binding site [ion binding]; other site 264462007445 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264462007446 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264462007447 putative C-terminal domain interface [polypeptide binding]; other site 264462007448 putative GSH binding site (G-site) [chemical binding]; other site 264462007449 putative dimer interface [polypeptide binding]; other site 264462007450 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264462007451 putative N-terminal domain interface [polypeptide binding]; other site 264462007452 putative dimer interface [polypeptide binding]; other site 264462007453 putative substrate binding pocket (H-site) [chemical binding]; other site 264462007454 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 264462007455 active site 264462007456 catalytic residues [active] 264462007457 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 264462007458 PA/protease domain interface [polypeptide binding]; other site 264462007459 putative integrin binding motif; other site 264462007460 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 264462007461 catalytic residues [active] 264462007462 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 264462007463 active site 264462007464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462007465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462007466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462007467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462007468 catalytic residue [active] 264462007469 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264462007470 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 264462007471 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 264462007472 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 264462007473 active site 264462007474 HflX GTPase family; Region: HflX; cd01878 264462007475 G1 box; other site 264462007476 GTP/Mg2+ binding site [chemical binding]; other site 264462007477 Switch I region; other site 264462007478 G2 box; other site 264462007479 G3 box; other site 264462007480 Switch II region; other site 264462007481 G4 box; other site 264462007482 G5 box; other site 264462007483 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007484 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007485 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007486 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007487 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007488 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007489 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007490 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007491 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007492 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007493 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 264462007494 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264462007495 active site 264462007496 catalytic site [active] 264462007497 substrate binding site [chemical binding]; other site 264462007498 WYL domain; Region: WYL; pfam13280 264462007499 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264462007500 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264462007501 flagellar motor protein MotA; Validated; Region: PRK09110 264462007502 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 264462007503 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 264462007504 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264462007505 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 264462007506 DsbD alpha interface [polypeptide binding]; other site 264462007507 catalytic residues [active] 264462007508 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 264462007509 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462007510 dimer interface [polypeptide binding]; other site 264462007511 putative CheW interface [polypeptide binding]; other site 264462007512 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 264462007513 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264462007514 metal ion-dependent adhesion site (MIDAS); other site 264462007515 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264462007516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264462007517 RNA binding surface [nucleotide binding]; other site 264462007518 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 264462007519 pseudouridine synthase; Region: TIGR00093 264462007520 active site 264462007521 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264462007522 EamA-like transporter family; Region: EamA; pfam00892 264462007523 EamA-like transporter family; Region: EamA; pfam00892 264462007524 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462007525 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 264462007526 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 264462007527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462007528 S-adenosylmethionine binding site [chemical binding]; other site 264462007529 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 264462007530 RNA methyltransferase, RsmE family; Region: TIGR00046 264462007531 RDD family; Region: RDD; pfam06271 264462007532 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 264462007533 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264462007534 active site 264462007535 nucleotide binding site [chemical binding]; other site 264462007536 HIGH motif; other site 264462007537 KMSKS motif; other site 264462007538 Flagellin N-methylase; Region: FliB; pfam03692 264462007539 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 264462007540 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264462007541 NodB motif; other site 264462007542 active site 264462007543 catalytic site [active] 264462007544 metal binding site [ion binding]; metal-binding site 264462007545 MFS/sugar transport protein; Region: MFS_2; pfam13347 264462007546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462007547 putative substrate translocation pore; other site 264462007548 O-Antigen ligase; Region: Wzy_C; pfam04932 264462007549 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264462007550 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 264462007551 nucleotide binding site [chemical binding]; other site 264462007552 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264462007553 SBD interface [polypeptide binding]; other site 264462007554 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 264462007555 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264462007556 putative active site [active] 264462007557 metal binding site [ion binding]; metal-binding site 264462007558 Predicted esterase [General function prediction only]; Region: COG0400 264462007559 putative hydrolase; Provisional; Region: PRK11460 264462007560 integral membrane protein; Region: integ_memb_HG; TIGR03954 264462007561 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264462007562 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264462007563 putative RNA binding site [nucleotide binding]; other site 264462007564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462007565 S-adenosylmethionine binding site [chemical binding]; other site 264462007566 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 264462007567 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264462007568 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264462007569 iron-sulfur cluster [ion binding]; other site 264462007570 [2Fe-2S] cluster binding site [ion binding]; other site 264462007571 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264462007572 hydrophobic ligand binding site; other site 264462007573 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 264462007574 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264462007575 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264462007576 homodimer interface [polypeptide binding]; other site 264462007577 NADP binding site [chemical binding]; other site 264462007578 substrate binding site [chemical binding]; other site 264462007579 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462007580 active site 264462007581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007582 active site 264462007583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007584 phosphorylation site [posttranslational modification] 264462007585 intermolecular recognition site; other site 264462007586 dimerization interface [polypeptide binding]; other site 264462007587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007588 dimer interface [polypeptide binding]; other site 264462007589 phosphorylation site [posttranslational modification] 264462007590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007591 ATP binding site [chemical binding]; other site 264462007592 Mg2+ binding site [ion binding]; other site 264462007593 G-X-G motif; other site 264462007594 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264462007595 Type II/IV secretion system protein; Region: T2SE; pfam00437 264462007596 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264462007597 Walker A motif; other site 264462007598 hexamer interface [polypeptide binding]; other site 264462007599 ATP binding site [chemical binding]; other site 264462007600 Walker B motif; other site 264462007601 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 264462007602 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 264462007603 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264462007604 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264462007605 dimer interface [polypeptide binding]; other site 264462007606 anticodon binding site; other site 264462007607 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264462007608 homodimer interface [polypeptide binding]; other site 264462007609 motif 1; other site 264462007610 active site 264462007611 motif 2; other site 264462007612 GAD domain; Region: GAD; pfam02938 264462007613 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264462007614 active site 264462007615 motif 3; other site 264462007616 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264462007617 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 264462007618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462007619 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264462007620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462007621 DNA binding residues [nucleotide binding] 264462007622 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 264462007623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264462007624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264462007625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264462007626 DNA binding residues [nucleotide binding] 264462007627 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264462007628 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 264462007629 P-loop; other site 264462007630 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 264462007631 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 264462007632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264462007633 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 264462007634 FHIPEP family; Region: FHIPEP; pfam00771 264462007635 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 264462007636 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 264462007637 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 264462007638 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 264462007639 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 264462007640 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 264462007641 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264462007642 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 264462007643 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 264462007644 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 264462007645 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 264462007646 CsbD-like; Region: CsbD; cl17424 264462007647 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 264462007648 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264462007649 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264462007650 active site 264462007651 dimerization interface [polypeptide binding]; other site 264462007652 Sporulation related domain; Region: SPOR; pfam05036 264462007653 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 264462007654 Part of AAA domain; Region: AAA_19; pfam13245 264462007655 Family description; Region: UvrD_C_2; pfam13538 264462007656 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264462007657 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264462007658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264462007659 dimer interface [polypeptide binding]; other site 264462007660 putative CheW interface [polypeptide binding]; other site 264462007661 flagellin; Provisional; Region: PRK12802 264462007662 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264462007663 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264462007664 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 264462007665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462007666 FeS/SAM binding site; other site 264462007667 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 264462007668 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264462007669 oligomerisation interface [polypeptide binding]; other site 264462007670 mobile loop; other site 264462007671 roof hairpin; other site 264462007672 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264462007673 Transglycosylase; Region: Transgly; pfam00912 264462007674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264462007675 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 264462007676 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 264462007677 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264462007678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462007679 FeS/SAM binding site; other site 264462007680 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264462007681 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 264462007682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007684 dimer interface [polypeptide binding]; other site 264462007685 phosphorylation site [posttranslational modification] 264462007686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007687 ATP binding site [chemical binding]; other site 264462007688 Mg2+ binding site [ion binding]; other site 264462007689 G-X-G motif; other site 264462007690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462007692 active site 264462007693 phosphorylation site [posttranslational modification] 264462007694 intermolecular recognition site; other site 264462007695 dimerization interface [polypeptide binding]; other site 264462007696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462007697 Walker A motif; other site 264462007698 ATP binding site [chemical binding]; other site 264462007699 Walker B motif; other site 264462007700 arginine finger; other site 264462007701 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462007702 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 264462007703 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 264462007704 FAD binding pocket [chemical binding]; other site 264462007705 FAD binding motif [chemical binding]; other site 264462007706 phosphate binding motif [ion binding]; other site 264462007707 NAD binding pocket [chemical binding]; other site 264462007708 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 264462007709 lipoprotein signal peptidase; Provisional; Region: PRK14787 264462007710 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 264462007711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007712 active site 264462007713 phosphorylation site [posttranslational modification] 264462007714 intermolecular recognition site; other site 264462007715 dimerization interface [polypeptide binding]; other site 264462007716 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462007717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007719 ATP binding site [chemical binding]; other site 264462007720 Mg2+ binding site [ion binding]; other site 264462007721 G-X-G motif; other site 264462007722 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264462007723 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264462007724 intersubunit interface [polypeptide binding]; other site 264462007725 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 264462007726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264462007727 Walker A/P-loop; other site 264462007728 ATP binding site [chemical binding]; other site 264462007729 Q-loop/lid; other site 264462007730 ABC transporter signature motif; other site 264462007731 Walker B; other site 264462007732 D-loop; other site 264462007733 H-loop/switch region; other site 264462007734 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462007735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462007736 ligand binding site [chemical binding]; other site 264462007737 flexible hinge region; other site 264462007738 cheY-homologous receiver domain; Region: REC; smart00448 264462007739 active site 264462007740 intermolecular recognition site; other site 264462007741 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264462007742 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264462007743 IHF dimer interface [polypeptide binding]; other site 264462007744 IHF - DNA interface [nucleotide binding]; other site 264462007745 6-phosphofructokinase; Provisional; Region: PRK03202 264462007746 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 264462007747 active site 264462007748 ADP/pyrophosphate binding site [chemical binding]; other site 264462007749 dimerization interface [polypeptide binding]; other site 264462007750 allosteric effector site; other site 264462007751 fructose-1,6-bisphosphate binding site; other site 264462007752 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264462007753 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 264462007754 putative ligand binding site [chemical binding]; other site 264462007755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264462007756 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264462007757 TM-ABC transporter signature motif; other site 264462007758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264462007759 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264462007760 TM-ABC transporter signature motif; other site 264462007761 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264462007762 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264462007763 Walker A/P-loop; other site 264462007764 ATP binding site [chemical binding]; other site 264462007765 Q-loop/lid; other site 264462007766 ABC transporter signature motif; other site 264462007767 Walker B; other site 264462007768 D-loop; other site 264462007769 H-loop/switch region; other site 264462007770 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264462007771 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264462007772 Walker A/P-loop; other site 264462007773 ATP binding site [chemical binding]; other site 264462007774 Q-loop/lid; other site 264462007775 ABC transporter signature motif; other site 264462007776 Walker B; other site 264462007777 D-loop; other site 264462007778 H-loop/switch region; other site 264462007779 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462007780 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462007781 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462007782 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 264462007783 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462007784 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 264462007785 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 264462007786 FecR protein; Region: FecR; pfam04773 264462007787 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264462007788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264462007789 dimerization interface [polypeptide binding]; other site 264462007790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007791 dimer interface [polypeptide binding]; other site 264462007792 phosphorylation site [posttranslational modification] 264462007793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007794 ATP binding site [chemical binding]; other site 264462007795 Mg2+ binding site [ion binding]; other site 264462007796 G-X-G motif; other site 264462007797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462007798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007799 active site 264462007800 phosphorylation site [posttranslational modification] 264462007801 intermolecular recognition site; other site 264462007802 dimerization interface [polypeptide binding]; other site 264462007803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462007804 DNA binding site [nucleotide binding] 264462007805 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 264462007806 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264462007807 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264462007808 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264462007809 flagellar operon protein; Region: flg_new; TIGR02530 264462007810 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 264462007811 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 264462007812 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 264462007813 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264462007814 Uncharacterized conserved protein [Function unknown]; Region: COG3334 264462007815 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 264462007816 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 264462007817 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 264462007818 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264462007819 Walker A motif/ATP binding site; other site 264462007820 Walker B motif; other site 264462007821 Flagellar assembly protein FliH; Region: FliH; pfam02108 264462007822 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 264462007823 MgtE intracellular N domain; Region: MgtE_N; cl15244 264462007824 FliG C-terminal domain; Region: FliG_C; pfam01706 264462007825 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 264462007826 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 264462007827 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 264462007828 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 264462007829 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 264462007830 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264462007831 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 264462007832 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 264462007833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264462007834 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462007835 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264462007836 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462007837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462007838 binding surface 264462007839 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462007840 TPR motif; other site 264462007841 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462007842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462007843 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264462007844 Permease; Region: Permease; pfam02405 264462007845 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264462007846 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264462007847 Walker A/P-loop; other site 264462007848 ATP binding site [chemical binding]; other site 264462007849 Q-loop/lid; other site 264462007850 ABC transporter signature motif; other site 264462007851 Walker B; other site 264462007852 D-loop; other site 264462007853 H-loop/switch region; other site 264462007854 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264462007855 mce related protein; Region: MCE; pfam02470 264462007856 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462007857 active site 264462007858 substrate binding sites [chemical binding]; other site 264462007859 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 264462007860 Protein of unknown function (DUF721); Region: DUF721; pfam05258 264462007861 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 264462007862 Glucose inhibited division protein A; Region: GIDA; pfam01134 264462007863 thymidine kinase; Provisional; Region: PRK04296 264462007864 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 264462007865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462007866 substrate binding pocket [chemical binding]; other site 264462007867 membrane-bound complex binding site; other site 264462007868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462007869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462007870 catalytic residue [active] 264462007871 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 264462007872 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264462007873 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264462007874 glutaminase active site [active] 264462007875 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264462007876 dimer interface [polypeptide binding]; other site 264462007877 active site 264462007878 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264462007879 dimer interface [polypeptide binding]; other site 264462007880 active site 264462007881 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 264462007882 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264462007883 Substrate binding site; other site 264462007884 Mg++ binding site; other site 264462007885 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264462007886 active site 264462007887 substrate binding site [chemical binding]; other site 264462007888 CoA binding site [chemical binding]; other site 264462007889 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 264462007890 putative active site [active] 264462007891 Zn binding site [ion binding]; other site 264462007892 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264462007893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462007894 motif II; other site 264462007895 GAF domain; Region: GAF; cl17456 264462007896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007898 dimer interface [polypeptide binding]; other site 264462007899 phosphorylation site [posttranslational modification] 264462007900 CHASE3 domain; Region: CHASE3; pfam05227 264462007901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462007902 dimer interface [polypeptide binding]; other site 264462007903 phosphorylation site [posttranslational modification] 264462007904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007905 ATP binding site [chemical binding]; other site 264462007906 Mg2+ binding site [ion binding]; other site 264462007907 G-X-G motif; other site 264462007908 Response regulator receiver domain; Region: Response_reg; pfam00072 264462007909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007910 active site 264462007911 phosphorylation site [posttranslational modification] 264462007912 intermolecular recognition site; other site 264462007913 dimerization interface [polypeptide binding]; other site 264462007914 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 264462007915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007916 Response regulator receiver domain; Region: Response_reg; pfam00072 264462007917 active site 264462007918 phosphorylation site [posttranslational modification] 264462007919 intermolecular recognition site; other site 264462007920 dimerization interface [polypeptide binding]; other site 264462007921 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264462007922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007923 active site 264462007924 phosphorylation site [posttranslational modification] 264462007925 intermolecular recognition site; other site 264462007926 dimerization interface [polypeptide binding]; other site 264462007927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462007928 Walker A motif; other site 264462007929 ATP binding site [chemical binding]; other site 264462007930 Walker B motif; other site 264462007931 arginine finger; other site 264462007932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462007933 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 264462007934 agmatinase; Region: agmatinase; TIGR01230 264462007935 oligomer interface [polypeptide binding]; other site 264462007936 putative active site [active] 264462007937 Mn binding site [ion binding]; other site 264462007938 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264462007939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264462007940 minor groove reading motif; other site 264462007941 helix-hairpin-helix signature motif; other site 264462007942 substrate binding pocket [chemical binding]; other site 264462007943 active site 264462007944 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 264462007945 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462007946 Immunoglobulin domain; Region: Ig; cl11960 264462007947 SPRY domain; Region: SPRY; cd11709 264462007948 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 264462007949 dimer interface [polypeptide binding]; other site 264462007950 allosteric magnesium binding site [ion binding]; other site 264462007951 active site 264462007952 aspartate-rich active site metal binding site; other site 264462007953 Schiff base residues; other site 264462007954 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 264462007955 NAD(P) binding pocket [chemical binding]; other site 264462007956 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 264462007957 porphobilinogen deaminase; Provisional; Region: PRK01066 264462007958 domain interfaces; other site 264462007959 active site 264462007960 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264462007961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264462007962 inhibitor-cofactor binding pocket; inhibition site 264462007963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462007964 catalytic residue [active] 264462007965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462007966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462007967 ATP binding site [chemical binding]; other site 264462007968 Mg2+ binding site [ion binding]; other site 264462007969 G-X-G motif; other site 264462007970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462007971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462007972 active site 264462007973 phosphorylation site [posttranslational modification] 264462007974 intermolecular recognition site; other site 264462007975 dimerization interface [polypeptide binding]; other site 264462007976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462007977 DNA binding site [nucleotide binding] 264462007978 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 264462007979 substrate binding site [chemical binding]; other site 264462007980 active site 264462007981 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 264462007982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462007983 FeS/SAM binding site; other site 264462007984 HemN C-terminal domain; Region: HemN_C; pfam06969 264462007985 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 264462007986 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462007987 ferrochelatase; Reviewed; Region: hemH; PRK00035 264462007988 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 264462007989 C-terminal domain interface [polypeptide binding]; other site 264462007990 active site 264462007991 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264462007992 active site 264462007993 N-terminal domain interface [polypeptide binding]; other site 264462007994 LrgB-like family; Region: LrgB; pfam04172 264462007995 LrgA family; Region: LrgA; pfam03788 264462007996 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 264462007997 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 264462007998 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264462007999 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264462008000 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 264462008001 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264462008002 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 264462008003 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264462008004 ATP binding site [chemical binding]; other site 264462008005 Mg++ binding site [ion binding]; other site 264462008006 motif III; other site 264462008007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462008008 nucleotide binding region [chemical binding]; other site 264462008009 ATP-binding site [chemical binding]; other site 264462008010 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264462008011 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264462008012 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264462008013 active site 264462008014 NTP binding site [chemical binding]; other site 264462008015 metal binding triad [ion binding]; metal-binding site 264462008016 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264462008017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008018 active site 264462008019 phosphorylation site [posttranslational modification] 264462008020 intermolecular recognition site; other site 264462008021 dimerization interface [polypeptide binding]; other site 264462008022 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264462008023 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264462008024 ligand binding site [chemical binding]; other site 264462008025 flexible hinge region; other site 264462008026 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 264462008027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462008028 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264462008029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008030 active site 264462008031 phosphorylation site [posttranslational modification] 264462008032 intermolecular recognition site; other site 264462008033 dimerization interface [polypeptide binding]; other site 264462008034 CheB methylesterase; Region: CheB_methylest; pfam01339 264462008035 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264462008036 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264462008037 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264462008038 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264462008039 putative binding surface; other site 264462008040 active site 264462008041 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264462008042 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264462008043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008044 ATP binding site [chemical binding]; other site 264462008045 G-X-G motif; other site 264462008046 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264462008047 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264462008048 Domain of unknown function (DUF333); Region: DUF333; pfam03891 264462008049 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 264462008050 active site 264462008051 transketolase; Reviewed; Region: PRK05899 264462008052 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264462008053 TPP-binding site [chemical binding]; other site 264462008054 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264462008055 PYR/PP interface [polypeptide binding]; other site 264462008056 dimer interface [polypeptide binding]; other site 264462008057 TPP binding site [chemical binding]; other site 264462008058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264462008059 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 264462008060 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264462008061 active site 264462008062 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 264462008063 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264462008064 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 264462008065 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264462008066 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462008067 cleavage site 264462008068 active site 264462008069 substrate binding sites [chemical binding]; other site 264462008070 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264462008071 cleavage site 264462008072 active site 264462008073 substrate binding sites [chemical binding]; other site 264462008074 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 264462008075 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 264462008076 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 264462008077 dimer interface [polypeptide binding]; other site 264462008078 tetramer interface [polypeptide binding]; other site 264462008079 PYR/PP interface [polypeptide binding]; other site 264462008080 TPP binding site [chemical binding]; other site 264462008081 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 264462008082 TPP-binding site; other site 264462008083 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264462008084 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 264462008085 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 264462008086 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264462008087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008088 S-adenosylmethionine binding site [chemical binding]; other site 264462008089 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264462008090 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264462008091 active site 264462008092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462008093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008094 active site 264462008095 phosphorylation site [posttranslational modification] 264462008096 intermolecular recognition site; other site 264462008097 dimerization interface [polypeptide binding]; other site 264462008098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 264462008099 DNA binding site [nucleotide binding] 264462008100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462008101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264462008102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264462008103 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264462008104 substrate binding site [chemical binding]; other site 264462008105 oxyanion hole (OAH) forming residues; other site 264462008106 trimer interface [polypeptide binding]; other site 264462008107 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 264462008108 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264462008109 Tetramer interface [polypeptide binding]; other site 264462008110 active site 264462008111 FMN-binding site [chemical binding]; other site 264462008112 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264462008113 ADP binding site [chemical binding]; other site 264462008114 magnesium binding site [ion binding]; other site 264462008115 putative shikimate binding site; other site 264462008116 Class I aldolases; Region: Aldolase_Class_I; cl17187 264462008117 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264462008118 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264462008119 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 264462008120 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 264462008121 putative active site [active] 264462008122 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264462008123 metal binding site [ion binding]; metal-binding site 264462008124 active site 264462008125 NAD binding site [chemical binding]; other site 264462008126 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264462008127 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264462008128 ligand binding site [chemical binding]; other site 264462008129 active site 264462008130 UGI interface [polypeptide binding]; other site 264462008131 catalytic site [active] 264462008132 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 264462008133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264462008134 active site 264462008135 catalytic tetrad [active] 264462008136 phosphodiesterase YaeI; Provisional; Region: PRK11340 264462008137 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264462008138 putative active site [active] 264462008139 putative metal binding site [ion binding]; other site 264462008140 Endonuclease I; Region: Endonuclease_1; pfam04231 264462008141 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 264462008142 putative active site [active] 264462008143 Zn binding site [ion binding]; other site 264462008144 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264462008145 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264462008146 LexA repressor; Validated; Region: PRK00215 264462008147 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264462008148 Catalytic site [active] 264462008149 Pirin-related protein [General function prediction only]; Region: COG1741 264462008150 Pirin; Region: Pirin; pfam02678 264462008151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462008152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462008153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462008154 dimerization interface [polypeptide binding]; other site 264462008155 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 264462008156 GAF domain; Region: GAF_2; pfam13185 264462008157 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264462008158 Cadherin repeat-like domain; Region: CA_like; cl15786 264462008159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462008160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462008161 Bacterial transcriptional repressor; Region: TetR; pfam13972 264462008162 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264462008163 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 264462008164 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264462008165 putative catalytic site [active] 264462008166 putative metal binding site [ion binding]; other site 264462008167 putative phosphate binding site [ion binding]; other site 264462008168 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264462008169 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264462008170 dimer interface [polypeptide binding]; other site 264462008171 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264462008172 catalytic triad [active] 264462008173 peroxidatic and resolving cysteines [active] 264462008174 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 264462008175 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008177 active site 264462008178 phosphorylation site [posttranslational modification] 264462008179 intermolecular recognition site; other site 264462008180 dimerization interface [polypeptide binding]; other site 264462008181 CHASE3 domain; Region: CHASE3; pfam05227 264462008182 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462008183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462008184 putative active site [active] 264462008185 heme pocket [chemical binding]; other site 264462008186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008187 dimer interface [polypeptide binding]; other site 264462008188 phosphorylation site [posttranslational modification] 264462008189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008190 ATP binding site [chemical binding]; other site 264462008191 Mg2+ binding site [ion binding]; other site 264462008192 G-X-G motif; other site 264462008193 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008195 active site 264462008196 phosphorylation site [posttranslational modification] 264462008197 intermolecular recognition site; other site 264462008198 dimerization interface [polypeptide binding]; other site 264462008199 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264462008200 putative binding surface; other site 264462008201 active site 264462008202 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 264462008203 Uncharacterized conserved protein [Function unknown]; Region: COG0397 264462008204 Hemerythrin; Region: Hemerythrin; cd12107 264462008205 Fe binding site [ion binding]; other site 264462008206 Predicted esterase [General function prediction only]; Region: COG0400 264462008207 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462008208 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264462008209 C-terminal peptidase (prc); Region: prc; TIGR00225 264462008210 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264462008211 protein binding site [polypeptide binding]; other site 264462008212 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264462008213 Catalytic dyad [active] 264462008214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462008215 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 264462008216 NAD(P) binding site [chemical binding]; other site 264462008217 active site 264462008218 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 264462008219 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 264462008220 cofactor binding site; other site 264462008221 metal binding site [ion binding]; metal-binding site 264462008222 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 264462008223 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264462008224 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264462008225 putative active site [active] 264462008226 putative metal binding site [ion binding]; other site 264462008227 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264462008228 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 264462008229 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264462008230 catalytic motif [active] 264462008231 Zn binding site [ion binding]; other site 264462008232 RibD C-terminal domain; Region: RibD_C; cl17279 264462008233 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264462008234 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264462008235 dimer interface [polypeptide binding]; other site 264462008236 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264462008237 active site 264462008238 Fe binding site [ion binding]; other site 264462008239 PIF1-like helicase; Region: PIF1; pfam05970 264462008240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462008241 Walker A motif; other site 264462008242 ATP binding site [chemical binding]; other site 264462008243 Walker B motif; other site 264462008244 Family description; Region: UvrD_C_2; pfam13538 264462008245 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 264462008246 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 264462008247 active site 264462008248 Zn binding site [ion binding]; other site 264462008249 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264462008250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264462008251 active site residue [active] 264462008252 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264462008253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264462008254 motif II; other site 264462008255 short chain dehydrogenase; Provisional; Region: PRK07454 264462008256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462008257 NAD(P) binding site [chemical binding]; other site 264462008258 active site 264462008259 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264462008260 oligomerization interface [polypeptide binding]; other site 264462008261 active site 264462008262 metal binding site [ion binding]; metal-binding site 264462008263 pantoate--beta-alanine ligase; Region: panC; TIGR00018 264462008264 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264462008265 active site 264462008266 ATP-binding site [chemical binding]; other site 264462008267 pantoate-binding site; other site 264462008268 HXXH motif; other site 264462008269 Flavoprotein; Region: Flavoprotein; pfam02441 264462008270 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 264462008271 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 264462008272 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264462008273 nucleotide binding site [chemical binding]; other site 264462008274 Type III pantothenate kinase; Region: Pan_kinase; cl17198 264462008275 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 264462008276 tetramerization interface [polypeptide binding]; other site 264462008277 active site 264462008278 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264462008279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008280 ABC transporter; Region: ABC_tran_2; pfam12848 264462008281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008282 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 264462008283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264462008285 ABC transporter; Region: ABC_tran_2; pfam12848 264462008286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008287 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264462008288 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264462008289 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 264462008290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264462008291 N-terminal plug; other site 264462008292 ligand-binding site [chemical binding]; other site 264462008293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264462008294 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264462008295 substrate binding pocket [chemical binding]; other site 264462008296 membrane-bound complex binding site; other site 264462008297 hinge residues; other site 264462008298 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264462008299 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264462008300 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264462008301 catalytic residue [active] 264462008302 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264462008303 active site 264462008304 catalytic residues [active] 264462008305 metal binding site [ion binding]; metal-binding site 264462008306 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264462008307 carboxyltransferase (CT) interaction site; other site 264462008308 biotinylation site [posttranslational modification]; other site 264462008309 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264462008310 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264462008311 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264462008312 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 264462008313 enoyl-CoA hydratase; Provisional; Region: PRK05995 264462008314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264462008315 substrate binding site [chemical binding]; other site 264462008316 oxyanion hole (OAH) forming residues; other site 264462008317 trimer interface [polypeptide binding]; other site 264462008318 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264462008319 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264462008320 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264462008321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008322 S-adenosylmethionine binding site [chemical binding]; other site 264462008323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264462008324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264462008325 Coenzyme A binding pocket [chemical binding]; other site 264462008326 hypothetical protein; Provisional; Region: PRK05421 264462008327 putative catalytic site [active] 264462008328 putative metal binding site [ion binding]; other site 264462008329 putative phosphate binding site [ion binding]; other site 264462008330 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264462008331 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 264462008332 Walker A/P-loop; other site 264462008333 ATP binding site [chemical binding]; other site 264462008334 Q-loop/lid; other site 264462008335 ABC transporter signature motif; other site 264462008336 Walker B; other site 264462008337 D-loop; other site 264462008338 H-loop/switch region; other site 264462008339 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 264462008340 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 264462008341 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 264462008342 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264462008343 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 264462008344 putative C-terminal domain interface [polypeptide binding]; other site 264462008345 putative GSH binding site (G-site) [chemical binding]; other site 264462008346 putative dimer interface [polypeptide binding]; other site 264462008347 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 264462008348 dimer interface [polypeptide binding]; other site 264462008349 N-terminal domain interface [polypeptide binding]; other site 264462008350 putative substrate binding pocket (H-site) [chemical binding]; other site 264462008351 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264462008352 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264462008353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008354 binding surface 264462008355 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264462008356 TPR motif; other site 264462008357 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 264462008358 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 264462008359 active site 264462008360 Zn binding site [ion binding]; other site 264462008361 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462008362 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264462008363 PLD-like domain; Region: PLDc_2; pfam13091 264462008364 putative active site [active] 264462008365 catalytic site [active] 264462008366 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 264462008367 Surface antigen; Region: Bac_surface_Ag; pfam01103 264462008368 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264462008369 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264462008370 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264462008371 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 264462008372 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264462008373 Interdomain contacts; other site 264462008374 Cytokine receptor motif; other site 264462008375 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 264462008376 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 264462008377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462008378 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462008379 putative active site [active] 264462008380 heme pocket [chemical binding]; other site 264462008381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008382 dimer interface [polypeptide binding]; other site 264462008383 phosphorylation site [posttranslational modification] 264462008384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008385 ATP binding site [chemical binding]; other site 264462008386 Mg2+ binding site [ion binding]; other site 264462008387 G-X-G motif; other site 264462008388 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008390 active site 264462008391 phosphorylation site [posttranslational modification] 264462008392 intermolecular recognition site; other site 264462008393 dimerization interface [polypeptide binding]; other site 264462008394 N-terminal domain of Bd3614-like deaminases; Region: Bd3614-N; pfam14442 264462008395 Bd3614-like deaminase; Region: Bd3614-deam; pfam14439 264462008396 active site 264462008397 Zn binding site [ion binding]; other site 264462008398 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264462008399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008400 S-adenosylmethionine binding site [chemical binding]; other site 264462008401 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 264462008402 spermidine synthase; Provisional; Region: PRK00811 264462008403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008404 S-adenosylmethionine binding site [chemical binding]; other site 264462008405 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264462008406 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264462008407 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264462008408 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264462008409 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264462008410 BON domain; Region: BON; pfam04972 264462008411 BON domain; Region: BON; pfam04972 264462008412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462008413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462008414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462008415 dimerization interface [polypeptide binding]; other site 264462008416 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 264462008417 Peptidase family M28; Region: Peptidase_M28; pfam04389 264462008418 active site 264462008419 metal binding site [ion binding]; metal-binding site 264462008420 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 264462008421 B12 binding domain; Region: B12-binding; pfam02310 264462008422 B12 binding site [chemical binding]; other site 264462008423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462008424 FeS/SAM binding site; other site 264462008425 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 264462008426 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 264462008427 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 264462008428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008429 S-adenosylmethionine binding site [chemical binding]; other site 264462008430 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264462008431 TM2 domain; Region: TM2; cl00984 264462008432 TM2 domain; Region: TM2; cl00984 264462008433 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264462008434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264462008435 NAD(P) binding site [chemical binding]; other site 264462008436 active site 264462008437 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264462008438 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264462008439 putative dimer interface [polypeptide binding]; other site 264462008440 transcription elongation factor GreA; Region: greA; TIGR01462 264462008441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462008442 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 264462008443 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 264462008444 active site 264462008445 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264462008446 hydrophobic ligand binding site; other site 264462008447 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264462008448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008450 ABC transporter; Region: ABC_tran_2; pfam12848 264462008451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264462008452 DTW domain; Region: DTW; cl01221 264462008453 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462008454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 264462008455 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 264462008456 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264462008457 DNA binding site [nucleotide binding] 264462008458 active site 264462008459 AbgT putative transporter family; Region: ABG_transport; cl17431 264462008460 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264462008461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462008462 putative active site [active] 264462008463 heme pocket [chemical binding]; other site 264462008464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008465 dimer interface [polypeptide binding]; other site 264462008466 phosphorylation site [posttranslational modification] 264462008467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008468 ATP binding site [chemical binding]; other site 264462008469 Mg2+ binding site [ion binding]; other site 264462008470 G-X-G motif; other site 264462008471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008472 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008473 active site 264462008474 phosphorylation site [posttranslational modification] 264462008475 intermolecular recognition site; other site 264462008476 dimerization interface [polypeptide binding]; other site 264462008477 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264462008478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008479 active site 264462008480 phosphorylation site [posttranslational modification] 264462008481 intermolecular recognition site; other site 264462008482 dimerization interface [polypeptide binding]; other site 264462008483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462008484 GAF domain; Region: GAF; pfam01590 264462008485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008486 dimer interface [polypeptide binding]; other site 264462008487 phosphorylation site [posttranslational modification] 264462008488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008489 ATP binding site [chemical binding]; other site 264462008490 Mg2+ binding site [ion binding]; other site 264462008491 G-X-G motif; other site 264462008492 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008494 active site 264462008495 phosphorylation site [posttranslational modification] 264462008496 intermolecular recognition site; other site 264462008497 dimerization interface [polypeptide binding]; other site 264462008498 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 264462008499 putative hydrophobic ligand binding site [chemical binding]; other site 264462008500 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 264462008501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 264462008502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462008503 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 264462008504 putative hydrophobic ligand binding site [chemical binding]; other site 264462008505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264462008506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462008507 putative substrate translocation pore; other site 264462008508 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 264462008509 CoA binding domain; Region: CoA_binding; cl17356 264462008510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264462008511 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264462008512 active site 264462008513 metal binding site [ion binding]; metal-binding site 264462008514 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264462008515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264462008516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264462008517 dimerization interface [polypeptide binding]; other site 264462008518 putative DNA binding site [nucleotide binding]; other site 264462008519 putative Zn2+ binding site [ion binding]; other site 264462008520 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 264462008521 putative hydrophobic ligand binding site [chemical binding]; other site 264462008522 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 264462008523 putative hydrophobic ligand binding site [chemical binding]; other site 264462008524 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 264462008525 putative metal binding site [ion binding]; other site 264462008526 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 264462008527 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 264462008528 active site 264462008529 putative catalytic site [active] 264462008530 phosphate binding site A [ion binding]; other site 264462008531 DNA binding site [nucleotide binding] 264462008532 metal binding site A [ion binding]; metal-binding site 264462008533 putative AP binding site [nucleotide binding]; other site 264462008534 putative metal binding site B [ion binding]; other site 264462008535 phosphate binding site B [ion binding]; other site 264462008536 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 264462008537 putative hydrophobic ligand binding site [chemical binding]; other site 264462008538 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 264462008539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264462008540 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 264462008541 putative hydrophobic ligand binding site [chemical binding]; other site 264462008542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462008543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462008544 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 264462008545 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264462008546 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 264462008547 conserved cys residue [active] 264462008548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462008549 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264462008550 putative active site [active] 264462008551 heme pocket [chemical binding]; other site 264462008552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264462008553 putative active site [active] 264462008554 heme pocket [chemical binding]; other site 264462008555 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264462008556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462008557 ATP binding site [chemical binding]; other site 264462008558 putative Mg++ binding site [ion binding]; other site 264462008559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462008560 nucleotide binding region [chemical binding]; other site 264462008561 ATP-binding site [chemical binding]; other site 264462008562 Cupin-like domain; Region: Cupin_8; pfam13621 264462008563 Predicted transcriptional regulators [Transcription]; Region: COG1733 264462008564 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264462008565 Pirin; Region: Pirin; pfam02678 264462008566 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 264462008567 active site 1 [active] 264462008568 dimer interface [polypeptide binding]; other site 264462008569 hexamer interface [polypeptide binding]; other site 264462008570 active site 2 [active] 264462008571 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264462008572 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264462008573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008574 S-adenosylmethionine binding site [chemical binding]; other site 264462008575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462008576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462008577 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264462008578 putative effector binding pocket; other site 264462008579 putative dimerization interface [polypeptide binding]; other site 264462008580 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264462008581 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462008582 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 264462008583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264462008584 putative substrate translocation pore; other site 264462008585 Uncharacterized conserved protein [Function unknown]; Region: COG4925 264462008586 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 264462008587 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264462008588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462008589 ATP binding site [chemical binding]; other site 264462008590 putative Mg++ binding site [ion binding]; other site 264462008591 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264462008592 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 264462008593 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264462008594 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 264462008595 HsdM N-terminal domain; Region: HsdM_N; pfam12161 264462008596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008597 S-adenosylmethionine binding site [chemical binding]; other site 264462008598 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 264462008599 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462008600 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264462008601 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264462008602 active site 264462008603 Protein of unknown function DUF45; Region: DUF45; pfam01863 264462008604 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 264462008605 serine/threonine protein kinase; Provisional; Region: PRK11768 264462008606 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264462008607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264462008608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264462008609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264462008610 dimerization interface [polypeptide binding]; other site 264462008611 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 264462008612 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264462008613 Predicted membrane protein [Function unknown]; Region: COG4270 264462008614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264462008615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264462008616 WHG domain; Region: WHG; pfam13305 264462008617 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462008618 isocitrate dehydrogenase; Validated; Region: PRK08299 264462008619 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 264462008620 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 264462008621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462008622 Walker A motif; other site 264462008623 ATP binding site [chemical binding]; other site 264462008624 Walker B motif; other site 264462008625 arginine finger; other site 264462008626 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264462008627 hypothetical protein; Validated; Region: PRK00153 264462008628 recombination protein RecR; Reviewed; Region: recR; PRK00076 264462008629 RecR protein; Region: RecR; pfam02132 264462008630 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264462008631 putative active site [active] 264462008632 putative metal-binding site [ion binding]; other site 264462008633 tetramer interface [polypeptide binding]; other site 264462008634 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 264462008635 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 264462008636 G1 box; other site 264462008637 GTP/Mg2+ binding site [chemical binding]; other site 264462008638 G2 box; other site 264462008639 Switch I region; other site 264462008640 G3 box; other site 264462008641 Switch II region; other site 264462008642 G4 box; other site 264462008643 G5 box; other site 264462008644 quinolinate synthetase; Provisional; Region: PRK09375 264462008645 Peptidase family M48; Region: Peptidase_M48; cl12018 264462008646 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264462008647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264462008650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264462008651 DNA binding site [nucleotide binding] 264462008652 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 264462008653 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 264462008654 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 264462008655 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264462008656 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264462008657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462008658 Walker A motif; other site 264462008659 ATP binding site [chemical binding]; other site 264462008660 Walker B motif; other site 264462008661 arginine finger; other site 264462008662 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264462008663 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264462008664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264462008665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008666 dimer interface [polypeptide binding]; other site 264462008667 phosphorylation site [posttranslational modification] 264462008668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008669 ATP binding site [chemical binding]; other site 264462008670 Mg2+ binding site [ion binding]; other site 264462008671 G-X-G motif; other site 264462008672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264462008673 Response regulator receiver domain; Region: Response_reg; pfam00072 264462008674 active site 264462008675 phosphorylation site [posttranslational modification] 264462008676 intermolecular recognition site; other site 264462008677 dimerization interface [polypeptide binding]; other site 264462008678 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264462008679 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 264462008680 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 264462008681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462008682 Walker A motif; other site 264462008683 ATP binding site [chemical binding]; other site 264462008684 Walker B motif; other site 264462008685 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264462008686 Clp protease; Region: CLP_protease; pfam00574 264462008687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264462008688 oligomer interface [polypeptide binding]; other site 264462008689 active site residues [active] 264462008690 multifunctional aminopeptidase A; Provisional; Region: PRK00913 264462008691 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264462008692 interface (dimer of trimers) [polypeptide binding]; other site 264462008693 Substrate-binding/catalytic site; other site 264462008694 Zn-binding sites [ion binding]; other site 264462008695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462008696 sequence-specific DNA binding site [nucleotide binding]; other site 264462008697 salt bridge; other site 264462008698 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 264462008699 Glutamate-cysteine ligase; Region: GshA; pfam08886 264462008700 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 264462008701 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 264462008702 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264462008703 P loop; other site 264462008704 Nucleotide binding site [chemical binding]; other site 264462008705 DTAP/Switch II; other site 264462008706 Switch I; other site 264462008707 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264462008708 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264462008709 P loop; other site 264462008710 Nucleotide binding site [chemical binding]; other site 264462008711 DTAP/Switch II; other site 264462008712 Switch I; other site 264462008713 trigger factor; Region: tig; TIGR00115 264462008714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264462008715 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264462008716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008717 binding surface 264462008718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008719 TPR motif; other site 264462008720 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008723 binding surface 264462008724 TPR motif; other site 264462008725 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264462008726 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264462008727 metal binding site [ion binding]; metal-binding site 264462008728 active site 264462008729 I-site; other site 264462008730 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264462008731 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264462008732 Peptidase family M23; Region: Peptidase_M23; pfam01551 264462008733 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264462008734 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 264462008735 active site 264462008736 tetramer interface; other site 264462008737 primosome assembly protein PriA; Validated; Region: PRK05580 264462008738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462008739 ATP binding site [chemical binding]; other site 264462008740 putative Mg++ binding site [ion binding]; other site 264462008741 helicase superfamily c-terminal domain; Region: HELICc; smart00490 264462008742 FAD dependent oxidoreductase; Region: DAO; pfam01266 264462008743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264462008744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264462008745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264462008746 dimer interface [polypeptide binding]; other site 264462008747 phosphorylation site [posttranslational modification] 264462008748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264462008749 ATP binding site [chemical binding]; other site 264462008750 Mg2+ binding site [ion binding]; other site 264462008751 G-X-G motif; other site 264462008752 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264462008753 rRNA interaction site [nucleotide binding]; other site 264462008754 S8 interaction site; other site 264462008755 putative laminin-1 binding site; other site 264462008756 elongation factor Ts; Provisional; Region: tsf; PRK09377 264462008757 UBA/TS-N domain; Region: UBA; pfam00627 264462008758 Elongation factor TS; Region: EF_TS; pfam00889 264462008759 Elongation factor TS; Region: EF_TS; pfam00889 264462008760 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264462008761 putative nucleotide binding site [chemical binding]; other site 264462008762 uridine monophosphate binding site [chemical binding]; other site 264462008763 homohexameric interface [polypeptide binding]; other site 264462008764 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264462008765 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264462008766 hinge region; other site 264462008767 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 264462008768 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 264462008769 catalytic residue [active] 264462008770 putative FPP diphosphate binding site; other site 264462008771 putative FPP binding hydrophobic cleft; other site 264462008772 dimer interface [polypeptide binding]; other site 264462008773 putative IPP diphosphate binding site; other site 264462008774 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 264462008775 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264462008776 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264462008777 active site 264462008778 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264462008779 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264462008780 protein binding site [polypeptide binding]; other site 264462008781 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264462008782 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264462008783 putative substrate binding region [chemical binding]; other site 264462008784 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264462008785 Glycoprotease family; Region: Peptidase_M22; pfam00814 264462008786 AAA domain; Region: AAA_31; pfam13614 264462008787 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 264462008788 P-loop; other site 264462008789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264462008790 DnaJ domain; Region: DnaJ; pfam00226 264462008791 Helix-turn-helix domain; Region: HTH_25; pfam13413 264462008792 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264462008793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264462008794 RNA binding surface [nucleotide binding]; other site 264462008795 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264462008796 active site 264462008797 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 264462008798 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 264462008799 active site 264462008800 DNA binding site [nucleotide binding] 264462008801 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 264462008802 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264462008803 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 264462008804 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264462008805 homodimer interface [polypeptide binding]; other site 264462008806 substrate-cofactor binding pocket; other site 264462008807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462008808 catalytic residue [active] 264462008809 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264462008810 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264462008811 dimer interface [polypeptide binding]; other site 264462008812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264462008813 catalytic residue [active] 264462008814 mce related protein; Region: MCE; pfam02470 264462008815 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264462008816 Permease; Region: Permease; pfam02405 264462008817 Permease; Region: Permease; pfam02405 264462008818 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264462008819 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264462008820 Walker A/P-loop; other site 264462008821 ATP binding site [chemical binding]; other site 264462008822 Q-loop/lid; other site 264462008823 ABC transporter signature motif; other site 264462008824 Walker B; other site 264462008825 D-loop; other site 264462008826 H-loop/switch region; other site 264462008827 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264462008828 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264462008829 Walker A/P-loop; other site 264462008830 ATP binding site [chemical binding]; other site 264462008831 Q-loop/lid; other site 264462008832 ABC transporter signature motif; other site 264462008833 Walker B; other site 264462008834 D-loop; other site 264462008835 H-loop/switch region; other site 264462008836 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264462008837 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 264462008838 CoA-ligase; Region: Ligase_CoA; pfam00549 264462008839 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 264462008840 CoA binding domain; Region: CoA_binding; smart00881 264462008841 CoA-ligase; Region: Ligase_CoA; pfam00549 264462008842 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462008843 Ligand Binding Site [chemical binding]; other site 264462008844 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462008845 Ligand Binding Site [chemical binding]; other site 264462008846 short chain dehydrogenase; Provisional; Region: PRK06172 264462008847 classical (c) SDRs; Region: SDR_c; cd05233 264462008848 NAD(P) binding site [chemical binding]; other site 264462008849 active site 264462008850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462008851 active site 264462008852 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264462008853 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264462008854 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264462008855 Walker A/P-loop; other site 264462008856 ATP binding site [chemical binding]; other site 264462008857 Q-loop/lid; other site 264462008858 ABC transporter signature motif; other site 264462008859 Walker B; other site 264462008860 D-loop; other site 264462008861 H-loop/switch region; other site 264462008862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264462008863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264462008864 FtsX-like permease family; Region: FtsX; pfam02687 264462008865 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264462008866 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264462008867 HlyD family secretion protein; Region: HlyD_3; pfam13437 264462008868 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462008869 Ligand Binding Site [chemical binding]; other site 264462008870 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264462008871 Ligand Binding Site [chemical binding]; other site 264462008872 KH domain; Region: KH_4; pfam13083 264462008873 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 264462008874 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 264462008875 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264462008876 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264462008877 active site 264462008878 multimer interface [polypeptide binding]; other site 264462008879 TRAM domain; Region: TRAM; cl01282 264462008880 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264462008881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462008882 S-adenosylmethionine binding site [chemical binding]; other site 264462008883 TPR repeat; Region: TPR_11; pfam13414 264462008884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008885 binding surface 264462008886 TPR motif; other site 264462008887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264462008888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008889 binding surface 264462008890 TPR motif; other site 264462008891 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264462008892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264462008893 non-specific DNA binding site [nucleotide binding]; other site 264462008894 salt bridge; other site 264462008895 sequence-specific DNA binding site [nucleotide binding]; other site 264462008896 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264462008897 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 264462008898 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264462008899 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264462008900 catalytic loop [active] 264462008901 iron binding site [ion binding]; other site 264462008902 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264462008903 active site 264462008904 catalytic site [active] 264462008905 substrate binding site [chemical binding]; other site 264462008906 NAD synthetase; Provisional; Region: PRK13981 264462008907 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 264462008908 multimer interface [polypeptide binding]; other site 264462008909 active site 264462008910 catalytic triad [active] 264462008911 protein interface 1 [polypeptide binding]; other site 264462008912 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264462008913 homodimer interface [polypeptide binding]; other site 264462008914 NAD binding pocket [chemical binding]; other site 264462008915 ATP binding pocket [chemical binding]; other site 264462008916 Mg binding site [ion binding]; other site 264462008917 active-site loop [active] 264462008918 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 264462008919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008920 binding surface 264462008921 TPR motif; other site 264462008922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264462008923 binding surface 264462008924 TPR motif; other site 264462008925 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 264462008926 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264462008927 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462008928 FeS/SAM binding site; other site 264462008929 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 264462008930 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264462008931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264462008932 active site 264462008933 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264462008934 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264462008935 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264462008936 active site 264462008937 (T/H)XGH motif; other site 264462008938 Oligomerisation domain; Region: Oligomerisation; pfam02410 264462008939 GTPase CgtA; Reviewed; Region: obgE; PRK12299 264462008940 GTP1/OBG; Region: GTP1_OBG; pfam01018 264462008941 Obg GTPase; Region: Obg; cd01898 264462008942 G1 box; other site 264462008943 GTP/Mg2+ binding site [chemical binding]; other site 264462008944 Switch I region; other site 264462008945 G2 box; other site 264462008946 G3 box; other site 264462008947 Switch II region; other site 264462008948 G4 box; other site 264462008949 G5 box; other site 264462008950 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264462008951 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 264462008952 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264462008953 ribonuclease G; Provisional; Region: PRK11712 264462008954 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264462008955 homodimer interface [polypeptide binding]; other site 264462008956 oligonucleotide binding site [chemical binding]; other site 264462008957 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 264462008958 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264462008959 Walker A motif; other site 264462008960 ATP binding site [chemical binding]; other site 264462008961 Walker B motif; other site 264462008962 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 264462008963 intersubunit interface [polypeptide binding]; other site 264462008964 active site 264462008965 catalytic residue [active] 264462008966 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 264462008967 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264462008968 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264462008969 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 264462008970 purine nucleoside phosphorylase; Provisional; Region: PRK08202 264462008971 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 264462008972 catalytic triad [active] 264462008973 putative active site [active] 264462008974 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 264462008975 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264462008976 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264462008977 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264462008978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264462008979 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264462008980 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264462008981 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264462008982 carboxyltransferase (CT) interaction site; other site 264462008983 biotinylation site [posttranslational modification]; other site 264462008984 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 264462008985 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264462008986 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264462008987 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264462008988 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264462008989 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264462008990 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264462008991 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264462008992 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 264462008993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264462008994 FeS/SAM binding site; other site 264462008995 HemN C-terminal domain; Region: HemN_C; pfam06969 264462008996 GrpE; Region: GrpE; pfam01025 264462008997 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264462008998 dimer interface [polypeptide binding]; other site 264462008999 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264462009000 chaperone protein DnaJ; Provisional; Region: PRK10767 264462009001 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264462009002 HSP70 interaction site [polypeptide binding]; other site 264462009003 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264462009004 substrate binding site [polypeptide binding]; other site 264462009005 dimer interface [polypeptide binding]; other site 264462009006 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264462009007 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 264462009008 putative ligand binding site [chemical binding]; other site 264462009009 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264462009010 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264462009011 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264462009012 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264462009013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462009014 Walker A motif; other site 264462009015 ATP binding site [chemical binding]; other site 264462009016 Walker B motif; other site 264462009017 arginine finger; other site 264462009018 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264462009019 HD domain; Region: HD_5; pfam13487 264462009020 Patatin-like phospholipase; Region: Patatin; pfam01734 264462009021 active site 264462009022 nucleophile elbow; other site 264462009023 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 264462009024 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264462009025 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264462009026 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264462009027 Protein of unknown function DUF58; Region: DUF58; pfam01882 264462009028 MoxR-like ATPases [General function prediction only]; Region: COG0714 264462009029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264462009030 Walker A motif; other site 264462009031 ATP binding site [chemical binding]; other site 264462009032 Walker B motif; other site 264462009033 arginine finger; other site 264462009034 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264462009035 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264462009036 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264462009037 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264462009038 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264462009039 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264462009040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264462009041 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 264462009042 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 264462009043 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 264462009044 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 264462009045 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 264462009046 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264462009047 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 264462009048 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264462009049 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 264462009050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264462009051 ATP binding site [chemical binding]; other site 264462009052 putative Mg++ binding site [ion binding]; other site 264462009053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264462009054 nucleotide binding region [chemical binding]; other site 264462009055 ATP-binding site [chemical binding]; other site 264462009056 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 264462009057 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264462009058 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 264462009059 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 264462009060 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264462009061 gamma subunit interface [polypeptide binding]; other site 264462009062 epsilon subunit interface [polypeptide binding]; other site 264462009063 LBP interface [polypeptide binding]; other site 264462009064 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264462009065 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264462009066 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264462009067 alpha subunit interaction interface [polypeptide binding]; other site 264462009068 Walker A motif; other site 264462009069 ATP binding site [chemical binding]; other site 264462009070 Walker B motif; other site 264462009071 inhibitor binding site; inhibition site 264462009072 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264462009073 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264462009074 core domain interface [polypeptide binding]; other site 264462009075 delta subunit interface [polypeptide binding]; other site 264462009076 epsilon subunit interface [polypeptide binding]; other site 264462009077 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264462009078 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264462009079 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264462009080 beta subunit interaction interface [polypeptide binding]; other site 264462009081 Walker A motif; other site 264462009082 ATP binding site [chemical binding]; other site 264462009083 Walker B motif; other site 264462009084 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264462009085 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 264462009086 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264462009087 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264462009088 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 264462009089 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 264462009090 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264462009091 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 264462009092 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 264462009093 ParB-like nuclease domain; Region: ParBc; pfam02195 264462009094 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264462009095 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264462009096 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462009097 P-loop; other site 264462009098 Magnesium ion binding site [ion binding]; other site 264462009099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264462009100 Magnesium ion binding site [ion binding]; other site 264462009101 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264462009102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264462009103 S-adenosylmethionine binding site [chemical binding]; other site 264462009104 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264462009105 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 264462009106 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264462009107 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264462009108 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264462009109 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264462009110 G1 box; other site 264462009111 GTP/Mg2+ binding site [chemical binding]; other site 264462009112 Switch I region; other site 264462009113 G2 box; other site 264462009114 Switch II region; other site 264462009115 G3 box; other site 264462009116 G4 box; other site 264462009117 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264462009118 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 264462009119 G-X-X-G motif; other site 264462009120 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 264462009121 RxxxH motif; other site 264462009122 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 264462009123 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 264462009124 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264462009125 Ribonuclease P; Region: Ribonuclease_P; pfam00825 264462009126 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399