-- dump date   	20140619_001427
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
395963000001	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
395963000002	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
395963000003	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963000004	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395963000005	putative active site [active]
395963000006	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395963000007	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395963000008	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
395963000009	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395963000010	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963000011	Chain length determinant protein; Region: Wzz; cl15801
395963000012	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395963000013	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963000014	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963000015	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
395963000016	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
395963000017	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
395963000018	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395963000019	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
395963000020	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
395963000021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395963000022	P-loop; other site
395963000023	Magnesium ion binding site [ion binding]; other site
395963000024	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
395963000025	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395963000026	Magnesium ion binding site [ion binding]; other site
395963000027	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
395963000028	ParB-like nuclease domain; Region: ParBc; pfam02195
395963000029	Replication initiator protein A; Region: RPA; pfam10134
395963000030	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395963000031	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395963000032	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395963000033	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395963000034	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963000035	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395963000036	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963000037	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395963000038	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395963000039	Walker A/P-loop; other site
395963000040	ATP binding site [chemical binding]; other site
395963000041	Q-loop/lid; other site
395963000042	ABC transporter signature motif; other site
395963000043	Walker B; other site
395963000044	D-loop; other site
395963000045	H-loop/switch region; other site
395963000046	DevC protein; Region: devC; TIGR01185
395963000047	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395963000048	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963000049	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963000050	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
395963000051	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
395963000052	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
395963000053	active site
395963000054	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
395963000055	active site
395963000056	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395963000057	phosphate binding site [ion binding]; other site
395963000058	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395963000059	phosphate binding site [ion binding]; other site
395963000060	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395963000061	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
395963000062	active site
395963000063	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395963000064	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395963000065	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
395963000066	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
395963000067	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
395963000068	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
395963000069	putative NADP binding site [chemical binding]; other site
395963000070	active site
395963000071	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
395963000072	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
395963000073	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395963000074	Beta-lactamase; Region: Beta-lactamase; pfam00144
395963000075	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395963000076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963000077	Walker A motif; other site
395963000078	ATP binding site [chemical binding]; other site
395963000079	Walker B motif; other site
395963000080	arginine finger; other site
395963000081	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963000082	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000083	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000084	oxidoreductase; Provisional; Region: PRK06196
395963000085	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395963000086	putative NAD(P) binding site [chemical binding]; other site
395963000087	active site
395963000088	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
395963000089	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
395963000090	active site
395963000091	oxyanion hole [active]
395963000092	catalytic triad [active]
395963000093	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963000094	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963000095	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963000096	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
395963000097	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963000098	Walker A motif; other site
395963000099	ATP binding site [chemical binding]; other site
395963000100	Walker B motif; other site
395963000101	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963000102	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963000103	AAA-like domain; Region: AAA_10; pfam12846
395963000104	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
395963000105	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
395963000106	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
395963000107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963000108	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
395963000109	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963000110	dimerization interface [polypeptide binding]; other site
395963000111	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395963000112	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395963000113	TrwC relaxase; Region: TrwC; pfam08751
395963000114	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
395963000115	AAA domain; Region: AAA_30; pfam13604
395963000116	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
395963000117	active site
395963000118	catalytic residues [active]
395963000119	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
395963000120	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
395963000121	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
395963000122	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395963000123	putative active site [active]
395963000124	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
395963000125	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963000126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963000127	Walker A/P-loop; other site
395963000128	ATP binding site [chemical binding]; other site
395963000129	Q-loop/lid; other site
395963000130	ABC transporter signature motif; other site
395963000131	Walker B; other site
395963000132	D-loop; other site
395963000133	H-loop/switch region; other site
395963000134	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
395963000135	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963000136	BRO family, N-terminal domain; Region: Bro-N; smart01040
395963000137	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395963000138	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
395963000139	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
395963000140	putative active site [active]
395963000141	Protein of unknown function (DUF736); Region: DUF736; pfam05284
395963000142	Protein of unknown function (DUF736); Region: DUF736; pfam05284
395963000143	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
395963000144	putative active site [active]
395963000145	DNA polymerase II large subunit; Provisional; Region: PRK14714
395963000146	plasmid partitioning protein; Provisional; Region: PRK13832
395963000147	ParB-like nuclease domain; Region: ParB; smart00470
395963000148	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
395963000149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963000150	S-adenosylmethionine binding site [chemical binding]; other site
395963000151	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
395963000152	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395963000153	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
395963000154	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
395963000155	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395963000156	hypothetical protein; Validated; Region: PRK00029
395963000157	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963000158	Walker A motif; other site
395963000159	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
395963000160	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395963000161	Part of AAA domain; Region: AAA_19; pfam13245
395963000162	Family description; Region: UvrD_C_2; pfam13538
395963000163	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
395963000164	Toprim-like; Region: Toprim_2; pfam13155
395963000165	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
395963000166	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395963000167	Catalytic site [active]
395963000168	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
395963000169	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
395963000170	active site
395963000171	DNA binding site [nucleotide binding]
395963000172	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
395963000173	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395963000174	RelB antitoxin; Region: RelB; cl01171
395963000175	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
395963000176	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
395963000177	5' RNA guide strand anchoring site; other site
395963000178	active site
395963000179	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
395963000180	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963000181	ATP binding site [chemical binding]; other site
395963000182	putative Mg++ binding site [ion binding]; other site
395963000183	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
395963000184	putative uracil binding site [chemical binding]; other site
395963000185	putative active site [active]
395963000186	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
395963000187	putative metal binding site [ion binding]; other site
395963000188	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
395963000189	TIR domain; Region: TIR_2; pfam13676
395963000190	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
395963000191	DNA binding site [nucleotide binding]
395963000192	dimer interface [polypeptide binding]; other site
395963000193	active site
395963000194	Int/Topo IB signature motif; other site
395963000195	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
395963000196	putative active site [active]
395963000197	homotetrameric interface [polypeptide binding]; other site
395963000198	metal binding site [ion binding]; metal-binding site
395963000199	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395963000200	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
395963000201	HTH DNA binding domain; Region: HTH_13; pfam11972
395963000202	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
395963000203	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
395963000204	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395963000205	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395963000206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963000207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963000208	active site
395963000209	phosphorylation site [posttranslational modification]
395963000210	intermolecular recognition site; other site
395963000211	dimerization interface [polypeptide binding]; other site
395963000212	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963000213	DNA binding site [nucleotide binding]
395963000214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963000215	ATP binding site [chemical binding]; other site
395963000216	Mg2+ binding site [ion binding]; other site
395963000217	G-X-G motif; other site
395963000218	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
395963000219	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
395963000220	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395963000221	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395963000222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963000223	conserved gate region; other site
395963000224	putative PBP binding loops; other site
395963000225	ABC-ATPase subunit interface; other site
395963000226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395963000227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963000228	dimer interface [polypeptide binding]; other site
395963000229	conserved gate region; other site
395963000230	putative PBP binding loops; other site
395963000231	ABC-ATPase subunit interface; other site
395963000232	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395963000233	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395963000234	Walker A/P-loop; other site
395963000235	ATP binding site [chemical binding]; other site
395963000236	Q-loop/lid; other site
395963000237	ABC transporter signature motif; other site
395963000238	Walker B; other site
395963000239	D-loop; other site
395963000240	H-loop/switch region; other site
395963000241	TOBE domain; Region: TOBE_2; pfam08402
395963000242	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
395963000243	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
395963000244	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
395963000245	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963000246	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
395963000247	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395963000248	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395963000249	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395963000250	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395963000251	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395963000252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
395963000253	Integrase core domain; Region: rve; pfam00665
395963000254	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
395963000255	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395963000256	TPP-binding site [chemical binding]; other site
395963000257	dimer interface [polypeptide binding]; other site
395963000258	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395963000259	PYR/PP interface [polypeptide binding]; other site
395963000260	dimer interface [polypeptide binding]; other site
395963000261	TPP binding site [chemical binding]; other site
395963000262	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395963000263	transaldolase-like protein; Provisional; Region: PTZ00411
395963000264	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
395963000265	active site
395963000266	dimer interface [polypeptide binding]; other site
395963000267	catalytic residue [active]
395963000268	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
395963000269	N- and C-terminal domain interface [polypeptide binding]; other site
395963000270	D-xylulose kinase; Region: XylB; TIGR01312
395963000271	active site
395963000272	MgATP binding site [chemical binding]; other site
395963000273	catalytic site [active]
395963000274	metal binding site [ion binding]; metal-binding site
395963000275	xylulose binding site [chemical binding]; other site
395963000276	homodimer interface [polypeptide binding]; other site
395963000277	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395963000278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963000279	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
395963000280	L-idonate 5-dehydrogenase; Region: PLN02702
395963000281	inhibitor binding site; inhibition site
395963000282	catalytic Zn binding site [ion binding]; other site
395963000283	structural Zn binding site [ion binding]; other site
395963000284	NADP binding site [chemical binding]; other site
395963000285	tetramer interface [polypeptide binding]; other site
395963000286	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963000287	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
395963000288	putative ligand binding site [chemical binding]; other site
395963000289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
395963000290	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395963000291	Transposase; Region: DDE_Tnp_ISL3; pfam01610
395963000292	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395963000293	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395963000294	putative dimer interface [polypeptide binding]; other site
395963000295	Hemerythrin-like domain; Region: Hr-like; cd12108
395963000296	Fe binding site [ion binding]; other site
395963000297	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395963000298	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395963000299	Isochorismatase family; Region: Isochorismatase; pfam00857
395963000300	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395963000301	catalytic triad [active]
395963000302	conserved cis-peptide bond; other site
395963000303	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395963000304	dimerization interface [polypeptide binding]; other site
395963000305	metal binding site [ion binding]; metal-binding site
395963000306	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963000307	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963000308	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
395963000309	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
395963000310	dinuclear metal binding motif [ion binding]; other site
395963000311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
395963000312	Helix-turn-helix domain; Region: HTH_28; pfam13518
395963000313	Homeodomain-like domain; Region: HTH_32; pfam13565
395963000314	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395963000315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395963000316	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395963000317	NADH dehydrogenase subunit D; Validated; Region: PRK06075
395963000318	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395963000319	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
395963000320	CheB methylesterase; Region: CheB_methylest; pfam01339
395963000321	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
395963000322	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
395963000323	PAS domain; Region: PAS_10; pfam13596
395963000324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963000325	putative active site [active]
395963000326	heme pocket [chemical binding]; other site
395963000327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963000328	PAS domain; Region: PAS_9; pfam13426
395963000329	putative active site [active]
395963000330	heme pocket [chemical binding]; other site
395963000331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395963000332	HWE histidine kinase; Region: HWE_HK; pfam07536
395963000333	CheB methylesterase; Region: CheB_methylest; pfam01339
395963000334	VMA21-like domain; Region: VMA21; pfam09446
395963000335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
395963000336	SnoaL-like domain; Region: SnoaL_2; pfam12680
395963000337	recombination and repair protein; Provisional; Region: PRK10869
395963000338	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963000339	non-specific DNA binding site [nucleotide binding]; other site
395963000340	salt bridge; other site
395963000341	sequence-specific DNA binding site [nucleotide binding]; other site
395963000342	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395963000343	Catalytic site [active]
395963000344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000346	Replication protein C N-terminal domain; Region: RP-C; pfam03428
395963000347	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
395963000348	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
395963000349	Staphylococcal nuclease homologues; Region: SNc; smart00318
395963000350	Catalytic site; other site
395963000351	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395963000352	exonuclease subunit SbcC; Provisional; Region: PRK10246
395963000353	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
395963000354	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963000355	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963000356	non-specific DNA binding site [nucleotide binding]; other site
395963000357	salt bridge; other site
395963000358	sequence-specific DNA binding site [nucleotide binding]; other site
395963000359	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
395963000360	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
395963000361	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
395963000362	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
395963000363	AAA-like domain; Region: AAA_10; pfam12846
395963000364	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
395963000365	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395963000366	IHF dimer interface [polypeptide binding]; other site
395963000367	IHF - DNA interface [nucleotide binding]; other site
395963000368	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
395963000369	DnaA N-terminal domain; Region: DnaA_N; pfam11638
395963000370	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
395963000371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963000372	Walker A motif; other site
395963000373	ATP binding site [chemical binding]; other site
395963000374	Walker B motif; other site
395963000375	arginine finger; other site
395963000376	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
395963000377	DnaA box-binding interface [nucleotide binding]; other site
395963000378	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
395963000379	active site
395963000380	putative DNA-binding cleft [nucleotide binding]; other site
395963000381	dimer interface [polypeptide binding]; other site
395963000382	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
395963000383	RuvA N terminal domain; Region: RuvA_N; pfam01330
395963000384	UGMP family protein; Validated; Region: PRK09604
395963000385	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
395963000386	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
395963000387	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
395963000388	domain interfaces; other site
395963000389	active site
395963000390	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
395963000391	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
395963000392	active site
395963000393	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
395963000394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963000395	Walker A/P-loop; other site
395963000396	ATP binding site [chemical binding]; other site
395963000397	Q-loop/lid; other site
395963000398	ABC transporter signature motif; other site
395963000399	Walker B; other site
395963000400	D-loop; other site
395963000401	H-loop/switch region; other site
395963000402	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395963000403	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395963000404	Cytochrome c2 [Energy production and conversion]; Region: COG3474
395963000405	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395963000406	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395963000407	catalytic triad [active]
395963000408	Protein of unknown function; Region: DUF3971; pfam13116
395963000409	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395963000410	Phosphoesterase family; Region: Phosphoesterase; pfam04185
395963000411	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
395963000412	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395963000413	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
395963000414	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
395963000415	NAD(P) binding site [chemical binding]; other site
395963000416	catalytic residues [active]
395963000417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000419	WHG domain; Region: WHG; pfam13305
395963000420	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
395963000421	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
395963000422	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
395963000423	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
395963000424	active site
395963000425	HIGH motif; other site
395963000426	dimer interface [polypeptide binding]; other site
395963000427	KMSKS motif; other site
395963000428	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963000429	RNA binding surface [nucleotide binding]; other site
395963000430	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
395963000431	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963000432	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
395963000433	NAD binding site [chemical binding]; other site
395963000434	putative substrate binding site 2 [chemical binding]; other site
395963000435	putative substrate binding site 1 [chemical binding]; other site
395963000436	active site
395963000437	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963000438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963000439	active site
395963000440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000442	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000443	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395963000444	NAD(P) binding site [chemical binding]; other site
395963000445	active site
395963000446	short chain dehydrogenase; Validated; Region: PRK06182
395963000447	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963000448	NADP binding site [chemical binding]; other site
395963000449	active site
395963000450	steroid binding site; other site
395963000451	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395963000452	Helix-turn-helix domain; Region: HTH_18; pfam12833
395963000453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963000454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000455	NADH(P)-binding; Region: NAD_binding_10; pfam13460
395963000456	NAD(P) binding site [chemical binding]; other site
395963000457	active site
395963000458	short chain dehydrogenase; Provisional; Region: PRK06197
395963000459	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395963000460	putative NAD(P) binding site [chemical binding]; other site
395963000461	active site
395963000462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000464	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963000465	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
395963000466	short chain dehydrogenase; Provisional; Region: PRK08263
395963000467	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963000468	NADP binding site [chemical binding]; other site
395963000469	active site
395963000470	steroid binding site; other site
395963000471	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395963000472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963000473	short chain dehydrogenase; Validated; Region: PRK06182
395963000474	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963000475	NADP binding site [chemical binding]; other site
395963000476	active site
395963000477	steroid binding site; other site
395963000478	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
395963000479	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395963000480	NAD binding site [chemical binding]; other site
395963000481	catalytic residues [active]
395963000482	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395963000483	Helix-turn-helix domain; Region: HTH_18; pfam12833
395963000484	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963000485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000486	active site
395963000487	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395963000488	tetramer interface [polypeptide binding]; other site
395963000489	active site
395963000490	Mg2+/Mn2+ binding site [ion binding]; other site
395963000491	isocitrate lyase; Region: PLN02892
395963000492	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963000493	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963000494	non-specific DNA binding site [nucleotide binding]; other site
395963000495	salt bridge; other site
395963000496	sequence-specific DNA binding site [nucleotide binding]; other site
395963000497	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395963000498	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395963000499	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395963000500	diaminopimelate decarboxylase; Region: lysA; TIGR01048
395963000501	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
395963000502	active site
395963000503	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395963000504	substrate binding site [chemical binding]; other site
395963000505	catalytic residues [active]
395963000506	dimer interface [polypeptide binding]; other site
395963000507	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
395963000508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963000509	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963000510	acetyl-CoA synthetase; Provisional; Region: PRK00174
395963000511	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
395963000512	active site
395963000513	CoA binding site [chemical binding]; other site
395963000514	acyl-activating enzyme (AAE) consensus motif; other site
395963000515	AMP binding site [chemical binding]; other site
395963000516	acetate binding site [chemical binding]; other site
395963000517	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963000518	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963000519	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963000520	putative effector binding pocket; other site
395963000521	dimerization interface [polypeptide binding]; other site
395963000522	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
395963000523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963000524	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963000525	Protein of unknown function (DUF992); Region: DUF992; pfam06186
395963000526	Predicted membrane protein [Function unknown]; Region: COG2246
395963000527	GtrA-like protein; Region: GtrA; pfam04138
395963000528	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
395963000529	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
395963000530	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
395963000531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000533	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963000534	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
395963000535	putative C-terminal domain interface [polypeptide binding]; other site
395963000536	putative GSH binding site (G-site) [chemical binding]; other site
395963000537	putative dimer interface [polypeptide binding]; other site
395963000538	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
395963000539	putative N-terminal domain interface [polypeptide binding]; other site
395963000540	putative dimer interface [polypeptide binding]; other site
395963000541	putative substrate binding pocket (H-site) [chemical binding]; other site
395963000542	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
395963000543	ThiC-associated domain; Region: ThiC-associated; pfam13667
395963000544	ThiC family; Region: ThiC; pfam01964
395963000545	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
395963000546	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
395963000547	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
395963000548	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
395963000549	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
395963000550	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
395963000551	CysD dimerization site [polypeptide binding]; other site
395963000552	G1 box; other site
395963000553	putative GEF interaction site [polypeptide binding]; other site
395963000554	GTP/Mg2+ binding site [chemical binding]; other site
395963000555	Switch I region; other site
395963000556	G2 box; other site
395963000557	G3 box; other site
395963000558	Switch II region; other site
395963000559	G4 box; other site
395963000560	G5 box; other site
395963000561	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
395963000562	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
395963000563	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
395963000564	ligand-binding site [chemical binding]; other site
395963000565	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
395963000566	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395963000567	Active Sites [active]
395963000568	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
395963000569	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
395963000570	Autotransporter beta-domain; Region: Autotransporter; smart00869
395963000571	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963000572	ATP binding site [chemical binding]; other site
395963000573	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395963000574	putative Mg++ binding site [ion binding]; other site
395963000575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963000576	nucleotide binding region [chemical binding]; other site
395963000577	ATP-binding site [chemical binding]; other site
395963000578	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
395963000579	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395963000580	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395963000581	aspartate aminotransferase; Provisional; Region: PRK05764
395963000582	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963000583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963000584	homodimer interface [polypeptide binding]; other site
395963000585	catalytic residue [active]
395963000586	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
395963000587	heme-binding site [chemical binding]; other site
395963000588	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395963000589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395963000590	dimer interface [polypeptide binding]; other site
395963000591	putative CheW interface [polypeptide binding]; other site
395963000592	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
395963000593	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
395963000594	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
395963000595	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
395963000596	dimer interface [polypeptide binding]; other site
395963000597	PYR/PP interface [polypeptide binding]; other site
395963000598	TPP binding site [chemical binding]; other site
395963000599	substrate binding site [chemical binding]; other site
395963000600	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395963000601	TPP-binding site [chemical binding]; other site
395963000602	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
395963000603	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
395963000604	heme-binding site [chemical binding]; other site
395963000605	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
395963000606	TPR repeat; Region: TPR_11; pfam13414
395963000607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963000608	binding surface
395963000609	TPR motif; other site
395963000610	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963000611	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
395963000612	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
395963000613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
395963000614	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395963000615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963000616	S-adenosylmethionine binding site [chemical binding]; other site
395963000617	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963000618	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963000619	active site
395963000620	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395963000621	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395963000622	FMN binding site [chemical binding]; other site
395963000623	active site
395963000624	substrate binding site [chemical binding]; other site
395963000625	catalytic residue [active]
395963000626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000627	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963000628	NAD(P) binding site [chemical binding]; other site
395963000629	active site
395963000630	methionine sulfoxide reductase A; Provisional; Region: PRK00058
395963000631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
395963000632	Intracellular septation protein A; Region: IspA; pfam04279
395963000633	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
395963000634	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963000635	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963000636	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395963000637	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963000638	catalytic residue [active]
395963000639	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
395963000640	putative ABC transporter; Region: ycf24; CHL00085
395963000641	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
395963000642	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
395963000643	Walker A/P-loop; other site
395963000644	ATP binding site [chemical binding]; other site
395963000645	Q-loop/lid; other site
395963000646	ABC transporter signature motif; other site
395963000647	Walker B; other site
395963000648	D-loop; other site
395963000649	H-loop/switch region; other site
395963000650	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
395963000651	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
395963000652	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395963000653	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
395963000654	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963000655	catalytic residue [active]
395963000656	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
395963000657	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395963000658	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
395963000659	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395963000660	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395963000661	shikimate binding site; other site
395963000662	NAD(P) binding site [chemical binding]; other site
395963000663	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
395963000664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963000665	putative substrate translocation pore; other site
395963000666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963000667	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
395963000668	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395963000669	ATP binding site [chemical binding]; other site
395963000670	Mg++ binding site [ion binding]; other site
395963000671	motif III; other site
395963000672	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963000673	nucleotide binding region [chemical binding]; other site
395963000674	ATP-binding site [chemical binding]; other site
395963000675	Iron permease FTR1 family; Region: FTR1; cl00475
395963000676	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395963000677	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395963000678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963000679	putative active site [active]
395963000680	heme pocket [chemical binding]; other site
395963000681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963000682	putative active site [active]
395963000683	heme pocket [chemical binding]; other site
395963000684	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395963000685	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395963000686	dimer interface [polypeptide binding]; other site
395963000687	putative CheW interface [polypeptide binding]; other site
395963000688	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963000689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963000690	protein binding site [polypeptide binding]; other site
395963000691	Cytochrome C' Region: Cytochrom_C_2; pfam01322
395963000692	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395963000693	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963000694	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
395963000695	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395963000696	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
395963000697	putative active site [active]
395963000698	putative metal binding site [ion binding]; other site
395963000699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963000700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963000701	non-specific DNA binding site [nucleotide binding]; other site
395963000702	salt bridge; other site
395963000703	sequence-specific DNA binding site [nucleotide binding]; other site
395963000704	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
395963000705	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963000706	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963000707	catalytic residue [active]
395963000708	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963000709	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
395963000710	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963000711	E3 interaction surface; other site
395963000712	lipoyl attachment site [posttranslational modification]; other site
395963000713	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
395963000714	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395963000715	alpha subunit interface [polypeptide binding]; other site
395963000716	TPP binding site [chemical binding]; other site
395963000717	heterodimer interface [polypeptide binding]; other site
395963000718	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395963000719	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
395963000720	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395963000721	tetramer interface [polypeptide binding]; other site
395963000722	TPP-binding site [chemical binding]; other site
395963000723	heterodimer interface [polypeptide binding]; other site
395963000724	phosphorylation loop region [posttranslational modification]
395963000725	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963000726	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963000727	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963000728	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963000729	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963000730	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395963000731	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
395963000732	dimer interface [polypeptide binding]; other site
395963000733	substrate binding site [chemical binding]; other site
395963000734	ATP binding site [chemical binding]; other site
395963000735	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395963000736	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
395963000737	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
395963000738	nucleotide binding site [chemical binding]; other site
395963000739	NEF interaction site [polypeptide binding]; other site
395963000740	SBD interface [polypeptide binding]; other site
395963000741	chaperone protein DnaJ; Provisional; Region: PRK10767
395963000742	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395963000743	HSP70 interaction site [polypeptide binding]; other site
395963000744	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
395963000745	substrate binding site [polypeptide binding]; other site
395963000746	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
395963000747	Zn binding sites [ion binding]; other site
395963000748	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395963000749	dimer interface [polypeptide binding]; other site
395963000750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963000752	S-adenosylmethionine binding site [chemical binding]; other site
395963000753	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
395963000754	active site
395963000755	dimer interface [polypeptide binding]; other site
395963000756	dihydrodipicolinate reductase; Provisional; Region: PRK00048
395963000757	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395963000758	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
395963000759	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
395963000760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963000761	Walker A motif; other site
395963000762	ATP binding site [chemical binding]; other site
395963000763	Walker B motif; other site
395963000764	arginine finger; other site
395963000765	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
395963000766	Fusaric acid resistance protein family; Region: FUSC; pfam04632
395963000767	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395963000768	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395963000769	MarR family; Region: MarR_2; pfam12802
395963000770	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963000771	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963000772	active site
395963000773	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
395963000774	Caspase domain; Region: Peptidase_C14; pfam00656
395963000775	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
395963000776	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
395963000777	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
395963000778	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395963000779	acyl-activating enzyme (AAE) consensus motif; other site
395963000780	AMP binding site [chemical binding]; other site
395963000781	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395963000782	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395963000783	dimerization interface [polypeptide binding]; other site
395963000784	DPS ferroxidase diiron center [ion binding]; other site
395963000785	ion pore; other site
395963000786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395963000787	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963000788	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963000789	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963000790	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395963000791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963000792	active site
395963000793	phosphorylation site [posttranslational modification]
395963000794	intermolecular recognition site; other site
395963000795	dimerization interface [polypeptide binding]; other site
395963000796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963000797	Walker A motif; other site
395963000798	ATP binding site [chemical binding]; other site
395963000799	Walker B motif; other site
395963000800	arginine finger; other site
395963000801	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963000802	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395963000803	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963000804	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
395963000805	catalytic center binding site [active]
395963000806	ATP binding site [chemical binding]; other site
395963000807	dihydropteroate synthase; Region: DHPS; TIGR01496
395963000808	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
395963000809	substrate binding pocket [chemical binding]; other site
395963000810	dimer interface [polypeptide binding]; other site
395963000811	inhibitor binding site; inhibition site
395963000812	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
395963000813	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
395963000814	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
395963000815	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963000816	inhibitor-cofactor binding pocket; inhibition site
395963000817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963000818	catalytic residue [active]
395963000819	ornithine carbamoyltransferase; Provisional; Region: PRK00779
395963000820	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395963000821	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395963000822	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
395963000823	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
395963000824	dimerization interface [polypeptide binding]; other site
395963000825	domain crossover interface; other site
395963000826	redox-dependent activation switch; other site
395963000827	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
395963000828	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
395963000829	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
395963000830	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
395963000831	[2Fe-2S] cluster binding site [ion binding]; other site
395963000832	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
395963000833	cytochrome b; Provisional; Region: CYTB; MTH00156
395963000834	Qi binding site; other site
395963000835	intrachain domain interface; other site
395963000836	interchain domain interface [polypeptide binding]; other site
395963000837	heme bH binding site [chemical binding]; other site
395963000838	heme bL binding site [chemical binding]; other site
395963000839	Qo binding site; other site
395963000840	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
395963000841	interchain domain interface [polypeptide binding]; other site
395963000842	intrachain domain interface; other site
395963000843	Qi binding site; other site
395963000844	Qo binding site; other site
395963000845	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
395963000846	TMAO/DMSO reductase; Reviewed; Region: PRK05363
395963000847	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395963000848	Moco binding site; other site
395963000849	metal coordination site [ion binding]; other site
395963000850	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
395963000851	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963000852	active site
395963000853	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395963000854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963000855	motif II; other site
395963000856	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
395963000857	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
395963000858	active site
395963000859	metal binding site [ion binding]; metal-binding site
395963000860	DNA binding site [nucleotide binding]
395963000861	AAA domain; Region: AAA_27; pfam13514
395963000862	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395963000863	nucleophile elbow; other site
395963000864	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395963000865	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395963000866	active site
395963000867	Fructosamine kinase; Region: Fructosamin_kin; cl17579
395963000868	Phosphotransferase enzyme family; Region: APH; pfam01636
395963000869	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
395963000870	putative FMN binding site [chemical binding]; other site
395963000871	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
395963000872	putative active site [active]
395963000873	putative catalytic site [active]
395963000874	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
395963000875	putative active site [active]
395963000876	putative catalytic site [active]
395963000877	GTP-binding protein YchF; Reviewed; Region: PRK09601
395963000878	YchF GTPase; Region: YchF; cd01900
395963000879	G1 box; other site
395963000880	GTP/Mg2+ binding site [chemical binding]; other site
395963000881	Switch I region; other site
395963000882	G2 box; other site
395963000883	Switch II region; other site
395963000884	G3 box; other site
395963000885	G4 box; other site
395963000886	G5 box; other site
395963000887	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
395963000888	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963000889	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963000890	membrane-bound complex binding site; other site
395963000891	hinge residues; other site
395963000892	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
395963000893	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
395963000894	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
395963000895	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963000896	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963000897	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395963000898	dimerization interface [polypeptide binding]; other site
395963000899	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
395963000900	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
395963000901	putative active site [active]
395963000902	metal binding site [ion binding]; metal-binding site
395963000903	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
395963000904	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
395963000905	tetrameric interface [polypeptide binding]; other site
395963000906	NAD binding site [chemical binding]; other site
395963000907	catalytic residues [active]
395963000908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963000909	metabolite-proton symporter; Region: 2A0106; TIGR00883
395963000910	putative substrate translocation pore; other site
395963000911	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
395963000912	N- and C-terminal domain interface [polypeptide binding]; other site
395963000913	D-xylulose kinase; Region: XylB; TIGR01312
395963000914	active site
395963000915	MgATP binding site [chemical binding]; other site
395963000916	catalytic site [active]
395963000917	metal binding site [ion binding]; metal-binding site
395963000918	xylulose binding site [chemical binding]; other site
395963000919	homodimer interface [polypeptide binding]; other site
395963000920	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395963000921	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395963000922	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395963000923	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
395963000924	dimer interface [polypeptide binding]; other site
395963000925	putative PBP binding regions; other site
395963000926	ABC-ATPase subunit  interface; other site
395963000927	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
395963000928	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
395963000929	metal binding site [ion binding]; metal-binding site
395963000930	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
395963000931	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963000932	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
395963000933	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395963000934	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395963000935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963000936	dimer interface [polypeptide binding]; other site
395963000937	phosphorylation site [posttranslational modification]
395963000938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963000939	ATP binding site [chemical binding]; other site
395963000940	Mg2+ binding site [ion binding]; other site
395963000941	G-X-G motif; other site
395963000942	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395963000943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963000944	active site
395963000945	phosphorylation site [posttranslational modification]
395963000946	intermolecular recognition site; other site
395963000947	dimerization interface [polypeptide binding]; other site
395963000948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963000949	Walker A motif; other site
395963000950	ATP binding site [chemical binding]; other site
395963000951	Walker B motif; other site
395963000952	arginine finger; other site
395963000953	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963000954	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
395963000955	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963000956	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963000957	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
395963000958	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395963000959	Cl- selectivity filter; other site
395963000960	Cl- binding residues [ion binding]; other site
395963000961	pore gating glutamate residue; other site
395963000962	dimer interface [polypeptide binding]; other site
395963000963	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395963000964	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
395963000965	Outer membrane efflux protein; Region: OEP; pfam02321
395963000966	Outer membrane efflux protein; Region: OEP; pfam02321
395963000967	Fusaric acid resistance protein family; Region: FUSC; pfam04632
395963000968	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395963000969	multidrug resistance protein MdtN; Provisional; Region: PRK10476
395963000970	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963000971	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963000972	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
395963000973	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
395963000974	putative active site [active]
395963000975	metal binding site [ion binding]; metal-binding site
395963000976	Major royal jelly protein; Region: MRJP; pfam03022
395963000977	Acetokinase family; Region: Acetate_kinase; cl17229
395963000978	propionate/acetate kinase; Provisional; Region: PRK12379
395963000979	phosphate acetyltransferase; Provisional; Region: PRK11890
395963000980	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
395963000981	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
395963000982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963000983	NAD(P) binding site [chemical binding]; other site
395963000984	active site
395963000985	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
395963000986	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
395963000987	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
395963000988	homopentamer interface [polypeptide binding]; other site
395963000989	active site
395963000990	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
395963000991	putative RNA binding site [nucleotide binding]; other site
395963000992	thiamine monophosphate kinase; Provisional; Region: PRK05731
395963000993	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
395963000994	ATP binding site [chemical binding]; other site
395963000995	dimerization interface [polypeptide binding]; other site
395963000996	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
395963000997	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
395963000998	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
395963000999	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
395963001000	substrate binding site; other site
395963001001	tetramer interface; other site
395963001002	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
395963001003	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
395963001004	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395963001005	trimer interface [polypeptide binding]; other site
395963001006	active site
395963001007	substrate binding site [chemical binding]; other site
395963001008	CoA binding site [chemical binding]; other site
395963001009	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395963001010	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395963001011	dimer interface [polypeptide binding]; other site
395963001012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963001013	catalytic residue [active]
395963001014	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
395963001015	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395963001016	substrate binding site [chemical binding]; other site
395963001017	ATP binding site [chemical binding]; other site
395963001018	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
395963001019	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
395963001020	substrate binding site [chemical binding]; other site
395963001021	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
395963001022	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
395963001023	gamma subunit interface [polypeptide binding]; other site
395963001024	epsilon subunit interface [polypeptide binding]; other site
395963001025	LBP interface [polypeptide binding]; other site
395963001026	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
395963001027	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395963001028	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
395963001029	alpha subunit interaction interface [polypeptide binding]; other site
395963001030	Walker A motif; other site
395963001031	ATP binding site [chemical binding]; other site
395963001032	Walker B motif; other site
395963001033	inhibitor binding site; inhibition site
395963001034	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395963001035	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
395963001036	core domain interface [polypeptide binding]; other site
395963001037	delta subunit interface [polypeptide binding]; other site
395963001038	epsilon subunit interface [polypeptide binding]; other site
395963001039	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
395963001040	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395963001041	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
395963001042	beta subunit interaction interface [polypeptide binding]; other site
395963001043	Walker A motif; other site
395963001044	ATP binding site [chemical binding]; other site
395963001045	Walker B motif; other site
395963001046	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395963001047	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
395963001048	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
395963001049	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
395963001050	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
395963001051	EF-hand domain pair; Region: EF_hand_5; pfam13499
395963001052	Lipopolysaccharide-assembly; Region: LptE; cl01125
395963001053	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
395963001054	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
395963001055	HIGH motif; other site
395963001056	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395963001057	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395963001058	active site
395963001059	KMSKS motif; other site
395963001060	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
395963001061	tRNA binding surface [nucleotide binding]; other site
395963001062	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
395963001063	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395963001064	catalytic residue [active]
395963001065	TPR repeat; Region: TPR_11; pfam13414
395963001066	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001067	binding surface
395963001068	TPR motif; other site
395963001069	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
395963001070	catalytic motif [active]
395963001071	Catalytic residue [active]
395963001072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
395963001073	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963001074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001075	active site
395963001076	phosphorylation site [posttranslational modification]
395963001077	intermolecular recognition site; other site
395963001078	dimerization interface [polypeptide binding]; other site
395963001079	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963001080	DNA binding site [nucleotide binding]
395963001081	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395963001082	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395963001083	ligand binding site [chemical binding]; other site
395963001084	flexible hinge region; other site
395963001085	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395963001086	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395963001087	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
395963001088	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395963001089	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
395963001090	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
395963001091	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
395963001092	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
395963001093	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
395963001094	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963001095	N-terminal plug; other site
395963001096	ligand-binding site [chemical binding]; other site
395963001097	CsbD-like; Region: CsbD; pfam05532
395963001098	pantothenate kinase; Provisional; Region: PRK05439
395963001099	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
395963001100	ATP-binding site [chemical binding]; other site
395963001101	CoA-binding site [chemical binding]; other site
395963001102	Mg2+-binding site [ion binding]; other site
395963001103	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
395963001104	metal binding site [ion binding]; metal-binding site
395963001105	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
395963001106	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
395963001107	substrate binding site [chemical binding]; other site
395963001108	glutamase interaction surface [polypeptide binding]; other site
395963001109	hypothetical protein; Provisional; Region: PRK14013
395963001110	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
395963001111	hypothetical protein; Provisional; Region: PRK09256
395963001112	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
395963001113	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
395963001114	catalytic residues [active]
395963001115	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
395963001116	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
395963001117	putative active site [active]
395963001118	oxyanion strand; other site
395963001119	catalytic triad [active]
395963001120	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
395963001121	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
395963001122	putative active site pocket [active]
395963001123	4-fold oligomerization interface [polypeptide binding]; other site
395963001124	metal binding residues [ion binding]; metal-binding site
395963001125	3-fold/trimer interface [polypeptide binding]; other site
395963001126	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
395963001127	active site
395963001128	HslU subunit interaction site [polypeptide binding]; other site
395963001129	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
395963001130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963001131	Walker A motif; other site
395963001132	ATP binding site [chemical binding]; other site
395963001133	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
395963001134	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395963001135	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
395963001136	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
395963001137	recombination protein RecR; Reviewed; Region: recR; PRK00076
395963001138	RecR protein; Region: RecR; pfam02132
395963001139	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
395963001140	putative active site [active]
395963001141	putative metal-binding site [ion binding]; other site
395963001142	tetramer interface [polypeptide binding]; other site
395963001143	hypothetical protein; Validated; Region: PRK00153
395963001144	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
395963001145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963001146	Walker A motif; other site
395963001147	ATP binding site [chemical binding]; other site
395963001148	Walker B motif; other site
395963001149	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
395963001150	arginine finger; other site
395963001151	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
395963001152	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
395963001153	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
395963001154	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
395963001155	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
395963001156	putative NADH binding site [chemical binding]; other site
395963001157	putative active site [active]
395963001158	nudix motif; other site
395963001159	putative metal binding site [ion binding]; other site
395963001160	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
395963001161	Ligand Binding Site [chemical binding]; other site
395963001162	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
395963001163	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395963001164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395963001165	ATP binding site [chemical binding]; other site
395963001166	putative Mg++ binding site [ion binding]; other site
395963001167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963001168	nucleotide binding region [chemical binding]; other site
395963001169	ATP-binding site [chemical binding]; other site
395963001170	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
395963001171	RNA binding site [nucleotide binding]; other site
395963001172	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
395963001173	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
395963001174	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
395963001175	GDP-binding site [chemical binding]; other site
395963001176	ACT binding site; other site
395963001177	IMP binding site; other site
395963001178	Predicted transcriptional regulators [Transcription]; Region: COG1733
395963001179	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395963001180	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395963001181	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395963001182	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
395963001183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963001184	substrate binding pocket [chemical binding]; other site
395963001185	membrane-bound complex binding site; other site
395963001186	hinge residues; other site
395963001187	siroheme synthase; Provisional; Region: cysG; PRK10637
395963001188	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
395963001189	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395963001190	active site
395963001191	SAM binding site [chemical binding]; other site
395963001192	homodimer interface [polypeptide binding]; other site
395963001193	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395963001194	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
395963001195	metal-binding site [ion binding]
395963001196	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963001197	translocation protein TolB; Provisional; Region: tolB; PRK05137
395963001198	TolB amino-terminal domain; Region: TolB_N; pfam04052
395963001199	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395963001200	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395963001201	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
395963001202	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395963001203	TolR protein; Region: tolR; TIGR02801
395963001204	TolQ protein; Region: tolQ; TIGR02796
395963001205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963001206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963001207	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963001208	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963001209	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963001210	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395963001211	active site
395963001212	TOBE domain; Region: TOBE; cl01440
395963001213	molybdenum transport protein ModD; Provisional; Region: PRK06096
395963001214	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
395963001215	active site
395963001216	TOBE domain; Region: TOBE; cl01440
395963001217	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
395963001218	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
395963001219	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395963001220	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
395963001221	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395963001222	putative di-iron ligands [ion binding]; other site
395963001223	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
395963001224	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963001225	DXD motif; other site
395963001226	short chain dehydrogenase; Provisional; Region: PRK07024
395963001227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963001228	NAD(P) binding site [chemical binding]; other site
395963001229	active site
395963001230	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
395963001231	active site
395963001232	catalytic site [active]
395963001233	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395963001234	dimanganese center [ion binding]; other site
395963001235	excinuclease ABC subunit B; Provisional; Region: PRK05298
395963001236	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963001237	ATP binding site [chemical binding]; other site
395963001238	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963001239	nucleotide binding region [chemical binding]; other site
395963001240	ATP-binding site [chemical binding]; other site
395963001241	Ultra-violet resistance protein B; Region: UvrB; pfam12344
395963001242	Fic/DOC family; Region: Fic; pfam02661
395963001243	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
395963001244	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395963001245	putative trimer interface [polypeptide binding]; other site
395963001246	putative CoA binding site [chemical binding]; other site
395963001247	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
395963001248	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395963001249	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395963001250	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395963001251	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395963001252	Surface antigen; Region: Bac_surface_Ag; pfam01103
395963001253	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
395963001254	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395963001255	active site
395963001256	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
395963001257	protein binding site [polypeptide binding]; other site
395963001258	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395963001259	putative substrate binding region [chemical binding]; other site
395963001260	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
395963001261	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
395963001262	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
395963001263	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
395963001264	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395963001265	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
395963001266	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
395963001267	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
395963001268	catalytic residue [active]
395963001269	putative FPP diphosphate  binding site; other site
395963001270	putative FPP binding hydrophobic cleft; other site
395963001271	dimer interface [polypeptide binding]; other site
395963001272	putative IPP diphosphate binding site; other site
395963001273	ribosome recycling factor; Reviewed; Region: frr; PRK00083
395963001274	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
395963001275	hinge region; other site
395963001276	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
395963001277	putative nucleotide binding site [chemical binding]; other site
395963001278	uridine monophosphate binding site [chemical binding]; other site
395963001279	homohexameric interface [polypeptide binding]; other site
395963001280	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
395963001281	Histidine kinase; Region: HisKA_3; pfam07730
395963001282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963001283	ATP binding site [chemical binding]; other site
395963001284	Mg2+ binding site [ion binding]; other site
395963001285	G-X-G motif; other site
395963001286	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395963001287	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963001288	Coenzyme A binding pocket [chemical binding]; other site
395963001289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963001290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001291	active site
395963001292	phosphorylation site [posttranslational modification]
395963001293	intermolecular recognition site; other site
395963001294	dimerization interface [polypeptide binding]; other site
395963001295	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963001296	DNA binding residues [nucleotide binding]
395963001297	dimerization interface [polypeptide binding]; other site
395963001298	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963001299	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963001300	hypothetical protein; Provisional; Region: PRK06034
395963001301	Chorismate mutase type II; Region: CM_2; pfam01817
395963001302	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
395963001303	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963001304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963001305	homodimer interface [polypeptide binding]; other site
395963001306	catalytic residue [active]
395963001307	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
395963001308	prephenate dehydrogenase; Validated; Region: PRK08507
395963001309	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963001310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963001311	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963001312	putative effector binding pocket; other site
395963001313	dimerization interface [polypeptide binding]; other site
395963001314	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963001315	Inward rectifier potassium channel; Region: IRK; pfam01007
395963001316	Outer membrane efflux protein; Region: OEP; pfam02321
395963001317	Outer membrane efflux protein; Region: OEP; pfam02321
395963001318	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395963001319	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395963001320	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395963001321	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
395963001322	Fic family protein [Function unknown]; Region: COG3177
395963001323	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395963001324	TPR repeat; Region: TPR_11; pfam13414
395963001325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001326	binding surface
395963001327	TPR motif; other site
395963001328	TPR repeat; Region: TPR_11; pfam13414
395963001329	TPR repeat; Region: TPR_11; pfam13414
395963001330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001331	binding surface
395963001332	TPR motif; other site
395963001333	TPR repeat; Region: TPR_11; pfam13414
395963001334	Predicted transcriptional regulator [Transcription]; Region: COG1959
395963001335	Transcriptional regulator; Region: Rrf2; pfam02082
395963001336	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
395963001337	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
395963001338	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963001339	metal binding site [ion binding]; metal-binding site
395963001340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963001341	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963001342	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
395963001343	GSH binding site [chemical binding]; other site
395963001344	catalytic residues [active]
395963001345	oxidoreductase; Provisional; Region: PRK06196
395963001346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963001347	NAD(P) binding site [chemical binding]; other site
395963001348	active site
395963001349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963001350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963001351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
395963001352	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
395963001353	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963001354	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
395963001355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001356	binding surface
395963001357	TPR motif; other site
395963001358	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
395963001359	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395963001360	NAD binding site [chemical binding]; other site
395963001361	homotetramer interface [polypeptide binding]; other site
395963001362	homodimer interface [polypeptide binding]; other site
395963001363	substrate binding site [chemical binding]; other site
395963001364	active site
395963001365	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
395963001366	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395963001367	dimer interface [polypeptide binding]; other site
395963001368	active site
395963001369	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
395963001370	active site 1 [active]
395963001371	dimer interface [polypeptide binding]; other site
395963001372	active site 2 [active]
395963001373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
395963001374	Bacitracin resistance protein BacA; Region: BacA; pfam02673
395963001375	heat shock protein GrpE; Provisional; Region: PRK14141
395963001376	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
395963001377	dimer interface [polypeptide binding]; other site
395963001378	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395963001379	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395963001380	Putative zinc-finger; Region: zf-HC2; pfam13490
395963001381	RNA polymerase sigma factor; Provisional; Region: PRK11924
395963001382	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963001383	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963001384	DNA binding residues [nucleotide binding]
395963001385	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
395963001386	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395963001387	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395963001388	active site
395963001389	metal binding site [ion binding]; metal-binding site
395963001390	Predicted ATPase [General function prediction only]; Region: COG4637
395963001391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963001392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001393	active site
395963001394	phosphorylation site [posttranslational modification]
395963001395	intermolecular recognition site; other site
395963001396	dimerization interface [polypeptide binding]; other site
395963001397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963001398	DNA binding site [nucleotide binding]
395963001399	hypothetical protein; Validated; Region: PRK00110
395963001400	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395963001401	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395963001402	C-terminal domain interface [polypeptide binding]; other site
395963001403	GSH binding site (G-site) [chemical binding]; other site
395963001404	dimer interface [polypeptide binding]; other site
395963001405	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
395963001406	N-terminal domain interface [polypeptide binding]; other site
395963001407	putative dimer interface [polypeptide binding]; other site
395963001408	active site
395963001409	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
395963001410	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395963001411	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963001412	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963001413	DNA binding residues [nucleotide binding]
395963001414	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395963001415	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963001416	RNA binding surface [nucleotide binding]; other site
395963001417	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395963001418	active site
395963001419	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
395963001420	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963001421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963001422	Walker A/P-loop; other site
395963001423	ATP binding site [chemical binding]; other site
395963001424	Q-loop/lid; other site
395963001425	ABC transporter signature motif; other site
395963001426	Walker B; other site
395963001427	D-loop; other site
395963001428	H-loop/switch region; other site
395963001429	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
395963001430	iron-sulfur cluster [ion binding]; other site
395963001431	[2Fe-2S] cluster binding site [ion binding]; other site
395963001432	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963001433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963001434	active site
395963001435	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963001436	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963001437	active site
395963001438	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
395963001439	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
395963001440	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
395963001441	ADP binding site [chemical binding]; other site
395963001442	magnesium binding site [ion binding]; other site
395963001443	putative shikimate binding site; other site
395963001444	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
395963001445	active site
395963001446	dimer interface [polypeptide binding]; other site
395963001447	metal binding site [ion binding]; metal-binding site
395963001448	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
395963001449	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
395963001450	heme binding site [chemical binding]; other site
395963001451	ferroxidase pore; other site
395963001452	ferroxidase diiron center [ion binding]; other site
395963001453	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395963001454	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395963001455	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395963001456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963001457	acetoin reductases; Region: 23BDH; TIGR02415
395963001458	NAD(P) binding site [chemical binding]; other site
395963001459	active site
395963001460	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395963001461	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963001462	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395963001463	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
395963001464	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
395963001465	active site
395963001466	HIGH motif; other site
395963001467	dimer interface [polypeptide binding]; other site
395963001468	KMSKS motif; other site
395963001469	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395963001470	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
395963001471	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395963001472	P loop; other site
395963001473	GTP binding site [chemical binding]; other site
395963001474	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
395963001475	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395963001476	Walker A/P-loop; other site
395963001477	ATP binding site [chemical binding]; other site
395963001478	Q-loop/lid; other site
395963001479	ABC transporter signature motif; other site
395963001480	Walker B; other site
395963001481	D-loop; other site
395963001482	H-loop/switch region; other site
395963001483	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
395963001484	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395963001485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963001486	putative active site [active]
395963001487	heme pocket [chemical binding]; other site
395963001488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963001489	putative active site [active]
395963001490	heme pocket [chemical binding]; other site
395963001491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963001492	PAS fold; Region: PAS_3; pfam08447
395963001493	putative active site [active]
395963001494	heme pocket [chemical binding]; other site
395963001495	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963001496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963001497	dimer interface [polypeptide binding]; other site
395963001498	phosphorylation site [posttranslational modification]
395963001499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963001500	ATP binding site [chemical binding]; other site
395963001501	Mg2+ binding site [ion binding]; other site
395963001502	G-X-G motif; other site
395963001503	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963001504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001505	active site
395963001506	phosphorylation site [posttranslational modification]
395963001507	intermolecular recognition site; other site
395963001508	dimerization interface [polypeptide binding]; other site
395963001509	NMT1-like family; Region: NMT1_2; pfam13379
395963001510	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963001511	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395963001512	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963001513	N-terminal plug; other site
395963001514	ligand-binding site [chemical binding]; other site
395963001515	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963001516	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963001517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963001518	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963001519	Coenzyme A binding pocket [chemical binding]; other site
395963001520	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963001521	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963001522	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
395963001523	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
395963001524	active site
395963001525	Zn binding site [ion binding]; other site
395963001526	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395963001527	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395963001528	putative NAD(P) binding site [chemical binding]; other site
395963001529	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
395963001530	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963001531	ATP binding site [chemical binding]; other site
395963001532	putative Mg++ binding site [ion binding]; other site
395963001533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963001534	nucleotide binding region [chemical binding]; other site
395963001535	ATP-binding site [chemical binding]; other site
395963001536	DEAD/H associated; Region: DEAD_assoc; pfam08494
395963001537	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
395963001538	putative active site [active]
395963001539	putative metal binding site [ion binding]; other site
395963001540	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
395963001541	Protein of unknown function (DUF535); Region: DUF535; cl01128
395963001542	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395963001543	IHF dimer interface [polypeptide binding]; other site
395963001544	IHF - DNA interface [nucleotide binding]; other site
395963001545	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
395963001546	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
395963001547	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
395963001548	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
395963001549	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
395963001550	amphipathic channel; other site
395963001551	Asn-Pro-Ala signature motifs; other site
395963001552	glycerol kinase; Provisional; Region: glpK; PRK00047
395963001553	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
395963001554	N- and C-terminal domain interface [polypeptide binding]; other site
395963001555	active site
395963001556	MgATP binding site [chemical binding]; other site
395963001557	catalytic site [active]
395963001558	metal binding site [ion binding]; metal-binding site
395963001559	putative homotetramer interface [polypeptide binding]; other site
395963001560	glycerol binding site [chemical binding]; other site
395963001561	homodimer interface [polypeptide binding]; other site
395963001562	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395963001563	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
395963001564	DNA binding site [nucleotide binding]
395963001565	heterodimer interface [polypeptide binding]; other site
395963001566	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395963001567	active site
395963001568	DNA binding site [nucleotide binding]
395963001569	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
395963001570	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395963001571	DNA binding site [nucleotide binding]
395963001572	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395963001573	nucleotide binding site [chemical binding]; other site
395963001574	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395963001575	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395963001576	putative DNA binding site [nucleotide binding]; other site
395963001577	putative homodimer interface [polypeptide binding]; other site
395963001578	Fic/DOC family; Region: Fic; cl00960
395963001579	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
395963001580	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
395963001581	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
395963001582	homodimer interface [polypeptide binding]; other site
395963001583	Walker A motif; other site
395963001584	ATP binding site [chemical binding]; other site
395963001585	hydroxycobalamin binding site [chemical binding]; other site
395963001586	Walker B motif; other site
395963001587	cobyric acid synthase; Provisional; Region: PRK00784
395963001588	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963001589	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
395963001590	catalytic triad [active]
395963001591	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
395963001592	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
395963001593	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963001594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963001595	homodimer interface [polypeptide binding]; other site
395963001596	catalytic residue [active]
395963001597	Fe2+ transport protein; Region: Iron_transport; pfam10634
395963001598	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
395963001599	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
395963001600	4Fe-4S binding domain; Region: Fer4_5; pfam12801
395963001601	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395963001602	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395963001603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963001604	Walker A motif; other site
395963001605	ATP binding site [chemical binding]; other site
395963001606	Walker B motif; other site
395963001607	arginine finger; other site
395963001608	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963001609	hypothetical protein; Provisional; Region: PRK13795
395963001610	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
395963001611	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
395963001612	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963001613	FeS/SAM binding site; other site
395963001614	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
395963001615	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395963001616	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395963001617	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
395963001618	NifZ domain; Region: NifZ; pfam04319
395963001619	NifZ domain; Region: NifZ; pfam04319
395963001620	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
395963001621	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395963001622	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963001623	catalytic residue [active]
395963001624	NifT/FixU protein; Region: NifT; pfam06988
395963001625	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
395963001626	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395963001627	inhibitor-cofactor binding pocket; inhibition site
395963001628	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963001629	catalytic residue [active]
395963001630	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
395963001631	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963001632	SIR2-like domain; Region: SIR2_2; pfam13289
395963001633	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395963001634	apolar tunnel; other site
395963001635	heme binding site [chemical binding]; other site
395963001636	dimerization interface [polypeptide binding]; other site
395963001637	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
395963001638	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
395963001639	active site
395963001640	(T/H)XGH motif; other site
395963001641	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
395963001642	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
395963001643	putative catalytic cysteine [active]
395963001644	gamma-glutamyl kinase; Provisional; Region: PRK05429
395963001645	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
395963001646	nucleotide binding site [chemical binding]; other site
395963001647	homotetrameric interface [polypeptide binding]; other site
395963001648	putative phosphate binding site [ion binding]; other site
395963001649	putative allosteric binding site; other site
395963001650	PUA domain; Region: PUA; pfam01472
395963001651	GTPase CgtA; Reviewed; Region: obgE; PRK12299
395963001652	GTP1/OBG; Region: GTP1_OBG; pfam01018
395963001653	Obg GTPase; Region: Obg; cd01898
395963001654	G1 box; other site
395963001655	GTP/Mg2+ binding site [chemical binding]; other site
395963001656	Switch I region; other site
395963001657	G2 box; other site
395963001658	G3 box; other site
395963001659	Switch II region; other site
395963001660	G4 box; other site
395963001661	G5 box; other site
395963001662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395963001663	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395963001664	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
395963001665	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
395963001666	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
395963001667	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395963001668	Peptidase family M23; Region: Peptidase_M23; pfam01551
395963001669	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
395963001670	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
395963001671	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395963001672	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395963001673	substrate binding pocket [chemical binding]; other site
395963001674	chain length determination region; other site
395963001675	substrate-Mg2+ binding site; other site
395963001676	catalytic residues [active]
395963001677	aspartate-rich region 1; other site
395963001678	active site lid residues [active]
395963001679	aspartate-rich region 2; other site
395963001680	Transglycosylase; Region: Transgly; pfam00912
395963001681	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
395963001682	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
395963001683	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395963001684	homotetramer interface [polypeptide binding]; other site
395963001685	NAD(P) binding site [chemical binding]; other site
395963001686	homodimer interface [polypeptide binding]; other site
395963001687	active site
395963001688	putative acyltransferase; Provisional; Region: PRK05790
395963001689	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395963001690	dimer interface [polypeptide binding]; other site
395963001691	active site
395963001692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
395963001693	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
395963001694	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
395963001695	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
395963001696	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
395963001697	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395963001698	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395963001699	putative hydrolase; Provisional; Region: PRK11460
395963001700	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395963001701	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
395963001702	active site
395963001703	HIGH motif; other site
395963001704	nucleotide binding site [chemical binding]; other site
395963001705	active site
395963001706	KMSKS motif; other site
395963001707	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
395963001708	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395963001709	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395963001710	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
395963001711	active site
395963001712	tetramer interface; other site
395963001713	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963001714	active site
395963001715	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
395963001716	ATP-grasp domain; Region: ATP-grasp; pfam02222
395963001717	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
395963001718	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963001719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001720	binding surface
395963001721	TPR motif; other site
395963001722	TPR repeat; Region: TPR_11; pfam13414
395963001723	TPR repeat; Region: TPR_11; pfam13414
395963001724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963001725	TPR motif; other site
395963001726	binding surface
395963001727	TPR repeat; Region: TPR_11; pfam13414
395963001728	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395963001729	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
395963001730	Protein of unknown function (DUF465); Region: DUF465; cl01070
395963001731	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395963001732	putative catalytic site [active]
395963001733	putative phosphate binding site [ion binding]; other site
395963001734	active site
395963001735	metal binding site A [ion binding]; metal-binding site
395963001736	DNA binding site [nucleotide binding]
395963001737	putative AP binding site [nucleotide binding]; other site
395963001738	putative metal binding site B [ion binding]; other site
395963001739	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
395963001740	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
395963001741	putative hydrolase; Provisional; Region: PRK11460
395963001742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963001743	active site
395963001744	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395963001745	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395963001746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963001747	S-adenosylmethionine binding site [chemical binding]; other site
395963001748	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
395963001749	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395963001750	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
395963001751	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
395963001752	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963001753	active site
395963001754	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395963001755	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
395963001756	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
395963001757	DNA binding site [nucleotide binding]
395963001758	catalytic residue [active]
395963001759	H2TH interface [polypeptide binding]; other site
395963001760	putative catalytic residues [active]
395963001761	turnover-facilitating residue; other site
395963001762	intercalation triad [nucleotide binding]; other site
395963001763	8OG recognition residue [nucleotide binding]; other site
395963001764	putative reading head residues; other site
395963001765	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
395963001766	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
395963001767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963001768	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963001769	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
395963001770	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
395963001771	G1 box; other site
395963001772	putative GEF interaction site [polypeptide binding]; other site
395963001773	GTP/Mg2+ binding site [chemical binding]; other site
395963001774	Switch I region; other site
395963001775	G2 box; other site
395963001776	G3 box; other site
395963001777	Switch II region; other site
395963001778	G4 box; other site
395963001779	G5 box; other site
395963001780	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
395963001781	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
395963001782	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
395963001783	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395963001784	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395963001785	PhoU domain; Region: PhoU; pfam01895
395963001786	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
395963001787	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
395963001788	putative active site [active]
395963001789	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963001790	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
395963001791	active site
395963001792	motif I; other site
395963001793	motif II; other site
395963001794	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395963001795	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
395963001796	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395963001797	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395963001798	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395963001799	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
395963001800	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
395963001801	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395963001802	TPP-binding site [chemical binding]; other site
395963001803	dimer interface [polypeptide binding]; other site
395963001804	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395963001805	PYR/PP interface [polypeptide binding]; other site
395963001806	dimer interface [polypeptide binding]; other site
395963001807	TPP binding site [chemical binding]; other site
395963001808	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395963001809	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
395963001810	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963001811	active site
395963001812	motif I; other site
395963001813	motif II; other site
395963001814	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963001815	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395963001816	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
395963001817	putative N-terminal domain interface [polypeptide binding]; other site
395963001818	putative dimer interface [polypeptide binding]; other site
395963001819	putative substrate binding pocket (H-site) [chemical binding]; other site
395963001820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963001821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963001822	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
395963001823	putative effector binding pocket; other site
395963001824	putative dimerization interface [polypeptide binding]; other site
395963001825	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
395963001826	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
395963001827	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
395963001828	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
395963001829	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
395963001830	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
395963001831	active site residue [active]
395963001832	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395963001833	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
395963001834	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395963001835	NADPH bind site [chemical binding]; other site
395963001836	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395963001837	putative FMN binding site [chemical binding]; other site
395963001838	NADPH bind site [chemical binding]; other site
395963001839	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
395963001840	active site residue [active]
395963001841	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
395963001842	ArsC family; Region: ArsC; pfam03960
395963001843	putative catalytic residues [active]
395963001844	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963001845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001846	active site
395963001847	phosphorylation site [posttranslational modification]
395963001848	intermolecular recognition site; other site
395963001849	dimerization interface [polypeptide binding]; other site
395963001850	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
395963001851	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
395963001852	Nucleotide-binding sites [chemical binding]; other site
395963001853	Walker A motif; other site
395963001854	Switch I region of nucleotide binding site; other site
395963001855	Fe4S4 binding sites [ion binding]; other site
395963001856	Switch II region of nucleotide binding site; other site
395963001857	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
395963001858	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
395963001859	MoFe protein alpha/beta subunit interactions; other site
395963001860	Alpha subunit P cluster binding residues; other site
395963001861	FeMoco binding residues [chemical binding]; other site
395963001862	MoFe protein alpha subunit/Fe protein contacts; other site
395963001863	MoFe protein dimer/ dimer interactions; other site
395963001864	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
395963001865	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
395963001866	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
395963001867	MoFe protein beta/alpha subunit interactions; other site
395963001868	Beta subunit P cluster binding residues; other site
395963001869	MoFe protein beta subunit/Fe protein contacts; other site
395963001870	MoFe protein dimer/ dimer interactions; other site
395963001871	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
395963001872	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
395963001873	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395963001874	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395963001875	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
395963001876	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
395963001877	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
395963001878	probable nitrogen fixation protein; Region: TIGR02935
395963001879	Rop-like; Region: Rop-like; pfam05082
395963001880	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
395963001881	NifQ; Region: NifQ; pfam04891
395963001882	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395963001883	NifU-like domain; Region: NifU; pfam01106
395963001884	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
395963001885	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
395963001886	active site
395963001887	catalytic residues [active]
395963001888	metal binding site [ion binding]; metal-binding site
395963001889	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
395963001890	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395963001891	Ligand binding site [chemical binding]; other site
395963001892	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395963001893	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395963001894	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395963001895	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395963001896	oxidoreductase; Provisional; Region: PRK10015
395963001897	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963001898	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
395963001899	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395963001900	metal binding site 2 [ion binding]; metal-binding site
395963001901	putative DNA binding helix; other site
395963001902	metal binding site 1 [ion binding]; metal-binding site
395963001903	structural Zn2+ binding site [ion binding]; other site
395963001904	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395963001905	catalytic core [active]
395963001906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963001907	Response regulator receiver domain; Region: Response_reg; pfam00072
395963001908	active site
395963001909	phosphorylation site [posttranslational modification]
395963001910	intermolecular recognition site; other site
395963001911	dimerization interface [polypeptide binding]; other site
395963001912	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395963001913	active site
395963001914	catalytic residues [active]
395963001915	metal binding site [ion binding]; metal-binding site
395963001916	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
395963001917	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
395963001918	putative active site [active]
395963001919	substrate binding site [chemical binding]; other site
395963001920	putative cosubstrate binding site; other site
395963001921	catalytic site [active]
395963001922	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
395963001923	substrate binding site [chemical binding]; other site
395963001924	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
395963001925	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
395963001926	dimerization interface 3.5A [polypeptide binding]; other site
395963001927	active site
395963001928	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
395963001929	MAPEG family; Region: MAPEG; cl09190
395963001930	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
395963001931	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
395963001932	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395963001933	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395963001934	ligand binding site [chemical binding]; other site
395963001935	flexible hinge region; other site
395963001936	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
395963001937	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
395963001938	FAD binding pocket [chemical binding]; other site
395963001939	FAD binding motif [chemical binding]; other site
395963001940	phosphate binding motif [ion binding]; other site
395963001941	beta-alpha-beta structure motif; other site
395963001942	NAD binding pocket [chemical binding]; other site
395963001943	Iron coordination center [ion binding]; other site
395963001944	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395963001945	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
395963001946	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
395963001947	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
395963001948	nickel binding site [ion binding]; other site
395963001949	Bacterial SH3 domain; Region: SH3_4; pfam06347
395963001950	Bacterial SH3 domain; Region: SH3_4; pfam06347
395963001951	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395963001952	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
395963001953	dimerization interface [polypeptide binding]; other site
395963001954	ligand binding site [chemical binding]; other site
395963001955	NADP binding site [chemical binding]; other site
395963001956	catalytic site [active]
395963001957	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395963001958	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395963001959	putative dimer interface [polypeptide binding]; other site
395963001960	Uncharacterized small protein [Function unknown]; Region: COG5568
395963001961	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
395963001962	tetramerization interface [polypeptide binding]; other site
395963001963	active site
395963001964	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395963001965	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963001966	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963001967	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963001968	active site
395963001969	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963001970	Protein of unknown function (DUF707); Region: DUF707; pfam05212
395963001971	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395963001972	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395963001973	active site
395963001974	catalytic residues [active]
395963001975	metal binding site [ion binding]; metal-binding site
395963001976	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395963001977	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180
395963001978	putative ligand binding site [chemical binding]; other site
395963001979	putative NAD binding site [chemical binding]; other site
395963001980	catalytic site [active]
395963001981	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395963001982	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
395963001983	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
395963001984	active site
395963001985	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963001986	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395963001987	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963001988	membrane-bound complex binding site; other site
395963001989	hinge residues; other site
395963001990	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963001991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963001992	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963001993	dimerization interface [polypeptide binding]; other site
395963001994	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963001995	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963001996	substrate binding pocket [chemical binding]; other site
395963001997	membrane-bound complex binding site; other site
395963001998	hinge residues; other site
395963001999	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395963002000	TolR protein; Region: tolR; TIGR02801
395963002001	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
395963002002	Gram-negative bacterial tonB protein; Region: TonB; cl10048
395963002003	hypothetical protein; Provisional; Region: PRK02268
395963002004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963002005	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
395963002006	putative dimer interface [polypeptide binding]; other site
395963002007	Predicted transcriptional regulator [Transcription]; Region: COG2378
395963002008	HTH domain; Region: HTH_11; pfam08279
395963002009	WYL domain; Region: WYL; pfam13280
395963002010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002011	S-adenosylmethionine binding site [chemical binding]; other site
395963002012	biotin synthase; Region: bioB; TIGR00433
395963002013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963002014	FeS/SAM binding site; other site
395963002015	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
395963002016	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
395963002017	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
395963002018	primosome assembly protein PriA; Validated; Region: PRK05580
395963002019	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963002020	ATP binding site [chemical binding]; other site
395963002021	putative Mg++ binding site [ion binding]; other site
395963002022	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395963002023	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963002024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
395963002025	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
395963002026	Peptidase family M50; Region: Peptidase_M50; pfam02163
395963002027	active site
395963002028	putative substrate binding region [chemical binding]; other site
395963002029	FOG: CBS domain [General function prediction only]; Region: COG0517
395963002030	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395963002031	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
395963002032	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
395963002033	active site
395963002034	Zn binding site [ion binding]; other site
395963002035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
395963002036	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395963002037	elongation factor G; Reviewed; Region: PRK12740
395963002038	G1 box; other site
395963002039	GTP/Mg2+ binding site [chemical binding]; other site
395963002040	G2 box; other site
395963002041	Switch I region; other site
395963002042	G3 box; other site
395963002043	Switch II region; other site
395963002044	G4 box; other site
395963002045	G5 box; other site
395963002046	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
395963002047	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395963002048	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395963002049	hypothetical protein; Provisional; Region: PRK07236
395963002050	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
395963002051	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
395963002052	30S subunit binding site; other site
395963002053	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963002054	DNA-binding site [nucleotide binding]; DNA binding site
395963002055	RNA-binding motif; other site
395963002056	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963002057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002058	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
395963002059	putative effector binding pocket; other site
395963002060	putative dimerization interface [polypeptide binding]; other site
395963002061	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
395963002062	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
395963002063	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
395963002064	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
395963002065	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395963002066	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963002067	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963002068	N-terminal plug; other site
395963002069	ligand-binding site [chemical binding]; other site
395963002070	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395963002071	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963002072	Walker A/P-loop; other site
395963002073	ATP binding site [chemical binding]; other site
395963002074	Q-loop/lid; other site
395963002075	ABC transporter signature motif; other site
395963002076	Walker B; other site
395963002077	D-loop; other site
395963002078	H-loop/switch region; other site
395963002079	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963002080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963002081	ABC-ATPase subunit interface; other site
395963002082	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963002083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963002084	dimer interface [polypeptide binding]; other site
395963002085	conserved gate region; other site
395963002086	putative PBP binding loops; other site
395963002087	ABC-ATPase subunit interface; other site
395963002088	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395963002089	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395963002090	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
395963002091	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
395963002092	active site
395963002093	iron coordination sites [ion binding]; other site
395963002094	substrate binding pocket [chemical binding]; other site
395963002095	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395963002096	Sulfatase; Region: Sulfatase; pfam00884
395963002097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963002098	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963002099	putative substrate translocation pore; other site
395963002100	Predicted methyltransferase [General function prediction only]; Region: COG3897
395963002101	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
395963002102	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
395963002103	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
395963002104	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
395963002105	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
395963002106	Cysteine-rich domain; Region: CCG; pfam02754
395963002107	Cysteine-rich domain; Region: CCG; pfam02754
395963002108	L-lactate permease; Region: Lactate_perm; cl00701
395963002109	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
395963002110	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
395963002111	maleylacetoacetate isomerase; Region: maiA; TIGR01262
395963002112	C-terminal domain interface [polypeptide binding]; other site
395963002113	GSH binding site (G-site) [chemical binding]; other site
395963002114	putative dimer interface [polypeptide binding]; other site
395963002115	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395963002116	substrate binding pocket (H-site) [chemical binding]; other site
395963002117	N-terminal domain interface [polypeptide binding]; other site
395963002118	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
395963002119	homodimer interaction site [polypeptide binding]; other site
395963002120	cofactor binding site; other site
395963002121	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
395963002122	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
395963002123	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395963002124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963002125	Walker A motif; other site
395963002126	ATP binding site [chemical binding]; other site
395963002127	Walker B motif; other site
395963002128	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
395963002129	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395963002130	iron-sulfur cluster [ion binding]; other site
395963002131	[2Fe-2S] cluster binding site [ion binding]; other site
395963002132	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
395963002133	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963002134	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
395963002135	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
395963002136	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
395963002137	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
395963002138	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
395963002139	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
395963002140	Walker A/P-loop; other site
395963002141	ATP binding site [chemical binding]; other site
395963002142	Q-loop/lid; other site
395963002143	ABC transporter signature motif; other site
395963002144	Walker B; other site
395963002145	D-loop; other site
395963002146	H-loop/switch region; other site
395963002147	OstA-like protein; Region: OstA; pfam03968
395963002148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
395963002149	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395963002150	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395963002151	catalytic site [active]
395963002152	putative active site [active]
395963002153	putative substrate binding site [chemical binding]; other site
395963002154	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
395963002155	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
395963002156	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395963002157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002158	S-adenosylmethionine binding site [chemical binding]; other site
395963002159	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395963002160	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395963002161	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963002162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963002163	Walker A/P-loop; other site
395963002164	ATP binding site [chemical binding]; other site
395963002165	Q-loop/lid; other site
395963002166	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963002167	ABC transporter signature motif; other site
395963002168	Walker B; other site
395963002169	D-loop; other site
395963002170	ABC transporter; Region: ABC_tran_2; pfam12848
395963002171	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963002172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963002173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002174	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
395963002175	putative effector binding pocket; other site
395963002176	putative dimerization interface [polypeptide binding]; other site
395963002177	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963002178	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963002179	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002180	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
395963002181	putative effector binding pocket; other site
395963002182	putative dimerization interface [polypeptide binding]; other site
395963002183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963002184	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395963002185	NAD(P) binding site [chemical binding]; other site
395963002186	active site
395963002187	short chain dehydrogenase; Provisional; Region: PRK12939
395963002188	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963002189	NADP binding site [chemical binding]; other site
395963002190	active site
395963002191	steroid binding site; other site
395963002192	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395963002193	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
395963002194	dimer interface [polypeptide binding]; other site
395963002195	substrate binding site [chemical binding]; other site
395963002196	metal binding sites [ion binding]; metal-binding site
395963002197	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395963002198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963002199	Coenzyme A binding pocket [chemical binding]; other site
395963002200	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395963002201	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
395963002202	Substrate binding site; other site
395963002203	metal-binding site
395963002204	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
395963002205	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
395963002206	Phosphotransferase enzyme family; Region: APH; pfam01636
395963002207	PAS fold; Region: PAS_7; pfam12860
395963002208	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395963002209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963002210	dimer interface [polypeptide binding]; other site
395963002211	phosphorylation site [posttranslational modification]
395963002212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963002213	ATP binding site [chemical binding]; other site
395963002214	Mg2+ binding site [ion binding]; other site
395963002215	G-X-G motif; other site
395963002216	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
395963002217	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
395963002218	homotetramer interface [polypeptide binding]; other site
395963002219	ligand binding site [chemical binding]; other site
395963002220	catalytic site [active]
395963002221	NAD binding site [chemical binding]; other site
395963002222	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963002223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963002224	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395963002225	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963002226	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963002227	active site
395963002228	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
395963002229	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395963002230	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395963002231	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395963002232	Walker A/P-loop; other site
395963002233	ATP binding site [chemical binding]; other site
395963002234	Q-loop/lid; other site
395963002235	ABC transporter signature motif; other site
395963002236	Walker B; other site
395963002237	D-loop; other site
395963002238	H-loop/switch region; other site
395963002239	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395963002240	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395963002241	2-isopropylmalate synthase; Validated; Region: PRK00915
395963002242	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
395963002243	active site
395963002244	catalytic residues [active]
395963002245	metal binding site [ion binding]; metal-binding site
395963002246	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395963002247	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395963002248	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395963002249	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
395963002250	putative binding site; other site
395963002251	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
395963002252	MG2 domain; Region: A2M_N; pfam01835
395963002253	Alpha-2-macroglobulin family; Region: A2M; pfam00207
395963002254	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
395963002255	surface patch; other site
395963002256	thioester region; other site
395963002257	specificity defining residues; other site
395963002258	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
395963002259	Transglycosylase; Region: Transgly; pfam00912
395963002260	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395963002261	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
395963002262	HTH-like domain; Region: HTH_21; pfam13276
395963002263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
395963002264	Integrase core domain; Region: rve; pfam00665
395963002265	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395963002266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963002267	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395963002268	active site clefts [active]
395963002269	zinc binding site [ion binding]; other site
395963002270	dimer interface [polypeptide binding]; other site
395963002271	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
395963002272	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395963002273	acyl-activating enzyme (AAE) consensus motif; other site
395963002274	AMP binding site [chemical binding]; other site
395963002275	active site
395963002276	CoA binding site [chemical binding]; other site
395963002277	enoyl-CoA hydratase; Provisional; Region: PRK05862
395963002278	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963002279	substrate binding site [chemical binding]; other site
395963002280	oxyanion hole (OAH) forming residues; other site
395963002281	trimer interface [polypeptide binding]; other site
395963002282	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395963002283	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
395963002284	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
395963002285	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963002286	substrate binding site [chemical binding]; other site
395963002287	oxyanion hole (OAH) forming residues; other site
395963002288	trimer interface [polypeptide binding]; other site
395963002289	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
395963002290	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395963002291	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
395963002292	substrate binding pocket [chemical binding]; other site
395963002293	FAD binding site [chemical binding]; other site
395963002294	catalytic base [active]
395963002295	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
395963002296	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
395963002297	tetrameric interface [polypeptide binding]; other site
395963002298	NAD binding site [chemical binding]; other site
395963002299	catalytic residues [active]
395963002300	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963002301	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002302	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963002303	dimerization interface [polypeptide binding]; other site
395963002304	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
395963002305	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
395963002306	NADP binding site [chemical binding]; other site
395963002307	homodimer interface [polypeptide binding]; other site
395963002308	active site
395963002309	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395963002310	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
395963002311	putative ligand binding site [chemical binding]; other site
395963002312	NAD binding site [chemical binding]; other site
395963002313	catalytic site [active]
395963002314	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395963002315	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395963002316	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395963002317	DNA binding site [nucleotide binding]
395963002318	domain linker motif; other site
395963002319	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
395963002320	putative ligand binding site [chemical binding]; other site
395963002321	putative dimerization interface [polypeptide binding]; other site
395963002322	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395963002323	ATP-binding site [chemical binding]; other site
395963002324	Gluconate-6-phosphate binding site [chemical binding]; other site
395963002325	Shikimate kinase; Region: SKI; pfam01202
395963002326	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963002327	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963002328	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395963002329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963002330	metabolite-proton symporter; Region: 2A0106; TIGR00883
395963002331	putative substrate translocation pore; other site
395963002332	Porin subfamily; Region: Porin_2; pfam02530
395963002333	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
395963002334	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395963002335	active site
395963002336	intersubunit interface [polypeptide binding]; other site
395963002337	catalytic residue [active]
395963002338	pyruvate kinase; Provisional; Region: PRK06247
395963002339	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395963002340	domain interfaces; other site
395963002341	active site
395963002342	Terminase-like family; Region: Terminase_6; pfam03237
395963002343	Phage terminase large subunit; Region: Terminase_3; cl12054
395963002344	Uncharacterized conserved protein [Function unknown]; Region: COG5323
395963002345	Phage-related protein [Function unknown]; Region: COG4695; cl01923
395963002346	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
395963002347	PLD-like domain; Region: PLDc_2; pfam13091
395963002348	putative active site [active]
395963002349	catalytic site [active]
395963002350	Chromate transporter; Region: Chromate_transp; pfam02417
395963002351	Chromate transporter; Region: Chromate_transp; pfam02417
395963002352	DNA polymerase III subunit chi; Validated; Region: PRK05728
395963002353	multifunctional aminopeptidase A; Provisional; Region: PRK00913
395963002354	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395963002355	interface (dimer of trimers) [polypeptide binding]; other site
395963002356	Substrate-binding/catalytic site; other site
395963002357	Zn-binding sites [ion binding]; other site
395963002358	Predicted permeases [General function prediction only]; Region: COG0795
395963002359	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395963002360	OstA-like protein; Region: OstA; cl00844
395963002361	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
395963002362	Organic solvent tolerance protein; Region: OstA_C; pfam04453
395963002363	SurA N-terminal domain; Region: SurA_N_3; cl07813
395963002364	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
395963002365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002366	S-adenosylmethionine binding site [chemical binding]; other site
395963002367	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395963002368	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
395963002369	active site
395963002370	FMN binding site [chemical binding]; other site
395963002371	substrate binding site [chemical binding]; other site
395963002372	homotetramer interface [polypeptide binding]; other site
395963002373	catalytic residue [active]
395963002374	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
395963002375	MgtC family; Region: MgtC; pfam02308
395963002376	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395963002377	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395963002378	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
395963002379	B1 nucleotide binding pocket [chemical binding]; other site
395963002380	B2 nucleotide binding pocket [chemical binding]; other site
395963002381	CAS motifs; other site
395963002382	active site
395963002383	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
395963002384	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963002385	DNA-binding site [nucleotide binding]; DNA binding site
395963002386	RNA-binding motif; other site
395963002387	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
395963002388	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
395963002389	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395963002390	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395963002391	active site
395963002392	hypothetical protein; Provisional; Region: PRK02853
395963002393	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
395963002394	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
395963002395	NAD binding site [chemical binding]; other site
395963002396	dimerization interface [polypeptide binding]; other site
395963002397	product binding site; other site
395963002398	substrate binding site [chemical binding]; other site
395963002399	zinc binding site [ion binding]; other site
395963002400	catalytic residues [active]
395963002401	The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874
395963002402	NUDIX domain; Region: NUDIX; pfam00293
395963002403	nudix motif; other site
395963002404	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395963002405	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963002406	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963002407	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963002408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002409	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963002410	dimerization interface [polypeptide binding]; other site
395963002411	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
395963002412	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395963002413	NADP binding site [chemical binding]; other site
395963002414	dimer interface [polypeptide binding]; other site
395963002415	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963002416	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963002417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963002418	dimer interface [polypeptide binding]; other site
395963002419	conserved gate region; other site
395963002420	ABC-ATPase subunit interface; other site
395963002421	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395963002422	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963002423	Walker A/P-loop; other site
395963002424	ATP binding site [chemical binding]; other site
395963002425	Q-loop/lid; other site
395963002426	ABC transporter signature motif; other site
395963002427	Walker B; other site
395963002428	D-loop; other site
395963002429	H-loop/switch region; other site
395963002430	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395963002431	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395963002432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963002433	putative active site [active]
395963002434	heme pocket [chemical binding]; other site
395963002435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963002436	dimer interface [polypeptide binding]; other site
395963002437	phosphorylation site [posttranslational modification]
395963002438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963002439	ATP binding site [chemical binding]; other site
395963002440	Mg2+ binding site [ion binding]; other site
395963002441	G-X-G motif; other site
395963002442	cell division protein MraZ; Reviewed; Region: PRK00326
395963002443	MraZ protein; Region: MraZ; pfam02381
395963002444	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
395963002445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002446	S-adenosylmethionine binding site [chemical binding]; other site
395963002447	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
395963002448	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
395963002449	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
395963002450	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395963002451	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
395963002452	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395963002453	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395963002454	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395963002455	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
395963002456	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395963002457	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395963002458	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395963002459	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
395963002460	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
395963002461	Mg++ binding site [ion binding]; other site
395963002462	putative catalytic motif [active]
395963002463	putative substrate binding site [chemical binding]; other site
395963002464	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
395963002465	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395963002466	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395963002467	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395963002468	cell division protein FtsW; Region: ftsW; TIGR02614
395963002469	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
395963002470	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
395963002471	active site
395963002472	homodimer interface [polypeptide binding]; other site
395963002473	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
395963002474	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395963002475	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395963002476	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395963002477	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
395963002478	FAD binding domain; Region: FAD_binding_4; pfam01565
395963002479	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
395963002480	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
395963002481	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
395963002482	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395963002483	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
395963002484	Cell division protein FtsQ; Region: FtsQ; pfam03799
395963002485	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
395963002486	Cell division protein FtsA; Region: FtsA; smart00842
395963002487	Cell division protein FtsA; Region: FtsA; pfam14450
395963002488	cell division protein FtsZ; Validated; Region: PRK09330
395963002489	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
395963002490	nucleotide binding site [chemical binding]; other site
395963002491	SulA interaction site; other site
395963002492	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
395963002493	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
395963002494	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
395963002495	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395963002496	Walker A/P-loop; other site
395963002497	ATP binding site [chemical binding]; other site
395963002498	Q-loop/lid; other site
395963002499	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395963002500	ABC transporter signature motif; other site
395963002501	Walker B; other site
395963002502	D-loop; other site
395963002503	H-loop/switch region; other site
395963002504	Cupin domain; Region: Cupin_2; cl17218
395963002505	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963002506	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963002507	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963002508	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963002509	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963002510	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
395963002511	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
395963002512	nucleotide binding pocket [chemical binding]; other site
395963002513	K-X-D-G motif; other site
395963002514	catalytic site [active]
395963002515	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
395963002516	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
395963002517	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
395963002518	Dimer interface [polypeptide binding]; other site
395963002519	BRCT sequence motif; other site
395963002520	CheB methylesterase; Region: CheB_methylest; pfam01339
395963002521	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395963002522	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
395963002523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002524	S-adenosylmethionine binding site [chemical binding]; other site
395963002525	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
395963002526	PAS domain; Region: PAS_10; pfam13596
395963002527	PAS domain S-box; Region: sensory_box; TIGR00229
395963002528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963002529	putative active site [active]
395963002530	heme pocket [chemical binding]; other site
395963002531	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395963002532	HWE histidine kinase; Region: HWE_HK; smart00911
395963002533	Response regulator receiver domain; Region: Response_reg; pfam00072
395963002534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963002535	active site
395963002536	phosphorylation site [posttranslational modification]
395963002537	intermolecular recognition site; other site
395963002538	dimerization interface [polypeptide binding]; other site
395963002539	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
395963002540	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395963002541	catalytic residues [active]
395963002542	central insert; other site
395963002543	heme exporter protein CcmC; Region: ccmC; TIGR01191
395963002544	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
395963002545	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
395963002546	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395963002547	dihydroorotase; Validated; Region: PRK09060
395963002548	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395963002549	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
395963002550	active site
395963002551	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
395963002552	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395963002553	nudix motif; other site
395963002554	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
395963002555	hypothetical protein; Validated; Region: PRK00228
395963002556	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
395963002557	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
395963002558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963002559	PAS fold; Region: PAS_3; pfam08447
395963002560	putative active site [active]
395963002561	heme pocket [chemical binding]; other site
395963002562	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395963002563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395963002564	metal binding site [ion binding]; metal-binding site
395963002565	active site
395963002566	I-site; other site
395963002567	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395963002568	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395963002569	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395963002570	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395963002571	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395963002572	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395963002573	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
395963002574	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
395963002575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963002576	catalytic residue [active]
395963002577	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
395963002578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395963002579	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
395963002580	Subunit III/VIIa interface [polypeptide binding]; other site
395963002581	Phospholipid binding site [chemical binding]; other site
395963002582	Subunit I/III interface [polypeptide binding]; other site
395963002583	Subunit III/VIb interface [polypeptide binding]; other site
395963002584	Subunit III/VIa interface; other site
395963002585	Subunit III/Vb interface [polypeptide binding]; other site
395963002586	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
395963002587	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
395963002588	UbiA prenyltransferase family; Region: UbiA; pfam01040
395963002589	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395963002590	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
395963002591	Subunit I/III interface [polypeptide binding]; other site
395963002592	D-pathway; other site
395963002593	Subunit I/VIIc interface [polypeptide binding]; other site
395963002594	Subunit I/IV interface [polypeptide binding]; other site
395963002595	Subunit I/II interface [polypeptide binding]; other site
395963002596	Low-spin heme (heme a) binding site [chemical binding]; other site
395963002597	Subunit I/VIIa interface [polypeptide binding]; other site
395963002598	Subunit I/VIa interface [polypeptide binding]; other site
395963002599	Dimer interface; other site
395963002600	Putative water exit pathway; other site
395963002601	Binuclear center (heme a3/CuB) [ion binding]; other site
395963002602	K-pathway; other site
395963002603	Subunit I/Vb interface [polypeptide binding]; other site
395963002604	Putative proton exit pathway; other site
395963002605	Subunit I/VIb interface; other site
395963002606	Subunit I/VIc interface [polypeptide binding]; other site
395963002607	Electron transfer pathway; other site
395963002608	Subunit I/VIIIb interface [polypeptide binding]; other site
395963002609	Subunit I/VIIb interface [polypeptide binding]; other site
395963002610	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
395963002611	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
395963002612	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395963002613	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
395963002614	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
395963002615	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395963002616	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
395963002617	lipoyl attachment site [posttranslational modification]; other site
395963002618	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
395963002619	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395963002620	tetramer interface [polypeptide binding]; other site
395963002621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963002622	catalytic residue [active]
395963002623	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395963002624	tetramer interface [polypeptide binding]; other site
395963002625	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963002626	catalytic residue [active]
395963002627	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
395963002628	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395963002629	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
395963002630	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395963002631	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
395963002632	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
395963002633	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
395963002634	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
395963002635	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395963002636	AAA domain; Region: AAA_23; pfam13476
395963002637	Walker A/P-loop; other site
395963002638	ATP binding site [chemical binding]; other site
395963002639	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395963002640	ABC transporter signature motif; other site
395963002641	Walker B; other site
395963002642	D-loop; other site
395963002643	H-loop/switch region; other site
395963002644	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
395963002645	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
395963002646	catalytic residues [active]
395963002647	Protein of unknown function (DUF721); Region: DUF721; cl02324
395963002648	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
395963002649	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395963002650	minor groove reading motif; other site
395963002651	helix-hairpin-helix signature motif; other site
395963002652	substrate binding pocket [chemical binding]; other site
395963002653	active site
395963002654	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
395963002655	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
395963002656	DNA binding and oxoG recognition site [nucleotide binding]
395963002657	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
395963002658	DNA methylase; Region: N6_N4_Mtase; pfam01555
395963002659	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
395963002660	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
395963002661	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
395963002662	putative active site [active]
395963002663	metal binding site [ion binding]; metal-binding site
395963002664	NAD synthetase; Provisional; Region: PRK13981
395963002665	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
395963002666	multimer interface [polypeptide binding]; other site
395963002667	active site
395963002668	catalytic triad [active]
395963002669	protein interface 1 [polypeptide binding]; other site
395963002670	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395963002671	homodimer interface [polypeptide binding]; other site
395963002672	NAD binding pocket [chemical binding]; other site
395963002673	ATP binding pocket [chemical binding]; other site
395963002674	Mg binding site [ion binding]; other site
395963002675	active-site loop [active]
395963002676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395963002677	binding surface
395963002678	TPR motif; other site
395963002679	TPR repeat; Region: TPR_11; pfam13414
395963002680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002681	binding surface
395963002682	TPR motif; other site
395963002683	TPR repeat; Region: TPR_11; pfam13414
395963002684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002685	binding surface
395963002686	TPR motif; other site
395963002687	TPR repeat; Region: TPR_11; pfam13414
395963002688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002689	binding surface
395963002690	TPR motif; other site
395963002691	TPR repeat; Region: TPR_11; pfam13414
395963002692	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963002693	Predicted membrane protein [Function unknown]; Region: COG1238
395963002694	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395963002695	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
395963002696	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
395963002697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963002698	FeS/SAM binding site; other site
395963002699	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
395963002700	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
395963002701	additional DNA contacts [nucleotide binding]; other site
395963002702	mismatch recognition site; other site
395963002703	active site
395963002704	zinc binding site [ion binding]; other site
395963002705	DNA intercalation site [nucleotide binding]; other site
395963002706	Uncharacterized conserved protein [Function unknown]; Region: COG4938
395963002707	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
395963002708	Protein of unknown function DUF262; Region: DUF262; pfam03235
395963002709	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
395963002710	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395963002711	cofactor binding site; other site
395963002712	DNA binding site [nucleotide binding]
395963002713	substrate interaction site [chemical binding]; other site
395963002714	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395963002715	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
395963002716	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
395963002717	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
395963002718	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395963002719	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395963002720	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
395963002721	CAAX protease self-immunity; Region: Abi; pfam02517
395963002722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
395963002723	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
395963002724	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
395963002725	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395963002726	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
395963002727	NAD binding site [chemical binding]; other site
395963002728	substrate binding site [chemical binding]; other site
395963002729	catalytic Zn binding site [ion binding]; other site
395963002730	tetramer interface [polypeptide binding]; other site
395963002731	structural Zn binding site [ion binding]; other site
395963002732	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395963002733	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
395963002734	NAD(P) binding site [chemical binding]; other site
395963002735	catalytic residues [active]
395963002736	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
395963002737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002738	S-adenosylmethionine binding site [chemical binding]; other site
395963002739	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
395963002740	ribonuclease PH; Reviewed; Region: rph; PRK00173
395963002741	Ribonuclease PH; Region: RNase_PH_bact; cd11362
395963002742	hexamer interface [polypeptide binding]; other site
395963002743	active site
395963002744	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
395963002745	active site
395963002746	dimerization interface [polypeptide binding]; other site
395963002747	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395963002748	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
395963002749	Part of AAA domain; Region: AAA_19; pfam13245
395963002750	Family description; Region: UvrD_C_2; pfam13538
395963002751	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963002752	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963002753	active site
395963002754	catalytic tetrad [active]
395963002755	transcriptional activator TtdR; Provisional; Region: PRK09801
395963002756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963002757	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963002758	putative effector binding pocket; other site
395963002759	dimerization interface [polypeptide binding]; other site
395963002760	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
395963002761	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
395963002762	NAD(P) binding site [chemical binding]; other site
395963002763	active site
395963002764	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
395963002765	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395963002766	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395963002767	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395963002768	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963002769	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
395963002770	putative NAD(P) binding site [chemical binding]; other site
395963002771	active site
395963002772	putative substrate binding site [chemical binding]; other site
395963002773	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395963002774	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963002775	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
395963002776	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
395963002777	Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341
395963002778	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
395963002779	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
395963002780	active site
395963002781	catalytic residues [active]
395963002782	Predicted acetyltransferase [General function prediction only]; Region: COG2388
395963002783	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
395963002784	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
395963002785	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
395963002786	homodimer interface [polypeptide binding]; other site
395963002787	NADP binding site [chemical binding]; other site
395963002788	substrate binding site [chemical binding]; other site
395963002789	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
395963002790	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
395963002791	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
395963002792	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
395963002793	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395963002794	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963002795	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963002796	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395963002797	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395963002798	Walker A/P-loop; other site
395963002799	ATP binding site [chemical binding]; other site
395963002800	Q-loop/lid; other site
395963002801	ABC transporter signature motif; other site
395963002802	Walker B; other site
395963002803	D-loop; other site
395963002804	H-loop/switch region; other site
395963002805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963002806	Walker A/P-loop; other site
395963002807	ATP binding site [chemical binding]; other site
395963002808	Q-loop/lid; other site
395963002809	ABC transporter signature motif; other site
395963002810	Walker B; other site
395963002811	D-loop; other site
395963002812	H-loop/switch region; other site
395963002813	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395963002814	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395963002815	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395963002816	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395963002817	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
395963002818	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395963002819	homodimer interface [polypeptide binding]; other site
395963002820	substrate-cofactor binding pocket; other site
395963002821	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963002822	catalytic residue [active]
395963002823	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
395963002824	AAA domain; Region: AAA_26; pfam13500
395963002825	hypothetical protein; Provisional; Region: PRK07505
395963002826	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
395963002827	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963002828	catalytic residue [active]
395963002829	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
395963002830	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963002831	inhibitor-cofactor binding pocket; inhibition site
395963002832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963002833	catalytic residue [active]
395963002834	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
395963002835	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395963002836	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
395963002837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963002838	Mg2+ binding site [ion binding]; other site
395963002839	G-X-G motif; other site
395963002840	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395963002841	anchoring element; other site
395963002842	dimer interface [polypeptide binding]; other site
395963002843	ATP binding site [chemical binding]; other site
395963002844	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
395963002845	active site
395963002846	putative metal-binding site [ion binding]; other site
395963002847	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395963002848	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
395963002849	Clp amino terminal domain; Region: Clp_N; pfam02861
395963002850	Clp amino terminal domain; Region: Clp_N; pfam02861
395963002851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963002852	Walker A motif; other site
395963002853	ATP binding site [chemical binding]; other site
395963002854	Walker B motif; other site
395963002855	arginine finger; other site
395963002856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963002857	Walker A motif; other site
395963002858	ATP binding site [chemical binding]; other site
395963002859	Walker B motif; other site
395963002860	arginine finger; other site
395963002861	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395963002862	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
395963002863	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
395963002864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963002865	S-adenosylmethionine binding site [chemical binding]; other site
395963002866	heat shock protein 90; Provisional; Region: PRK05218
395963002867	ATP binding site [chemical binding]; other site
395963002868	Mg2+ binding site [ion binding]; other site
395963002869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
395963002870	G-X-G motif; other site
395963002871	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
395963002872	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
395963002873	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
395963002874	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
395963002875	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395963002876	FtsX-like permease family; Region: FtsX; pfam02687
395963002877	FtsX-like permease family; Region: FtsX; pfam02687
395963002878	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
395963002879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395963002880	Walker A/P-loop; other site
395963002881	ATP binding site [chemical binding]; other site
395963002882	Q-loop/lid; other site
395963002883	ABC transporter signature motif; other site
395963002884	Walker B; other site
395963002885	D-loop; other site
395963002886	H-loop/switch region; other site
395963002887	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
395963002888	active site
395963002889	catalytic triad [active]
395963002890	oxyanion hole [active]
395963002891	switch loop; other site
395963002892	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
395963002893	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395963002894	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395963002895	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395963002896	Cytochrome P450; Region: p450; pfam00067
395963002897	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
395963002898	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
395963002899	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395963002900	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963002901	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
395963002902	putative ADP-binding pocket [chemical binding]; other site
395963002903	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
395963002904	Chain length determinant protein; Region: Wzz; cl15801
395963002905	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
395963002906	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
395963002907	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395963002908	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963002909	active site
395963002910	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963002911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963002912	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963002913	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963002914	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963002915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963002916	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963002917	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
395963002918	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963002919	active site
395963002920	Condensation domain; Region: Condensation; pfam00668
395963002921	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
395963002922	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395963002923	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
395963002924	acyl-activating enzyme (AAE) consensus motif; other site
395963002925	AMP binding site [chemical binding]; other site
395963002926	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395963002927	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
395963002928	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395963002929	active site
395963002930	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395963002931	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395963002932	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395963002933	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
395963002934	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963002935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963002936	catalytic residue [active]
395963002937	Condensation domain; Region: Condensation; pfam00668
395963002938	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
395963002939	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395963002940	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
395963002941	acyl-activating enzyme (AAE) consensus motif; other site
395963002942	AMP binding site [chemical binding]; other site
395963002943	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395963002944	Condensation domain; Region: Condensation; pfam00668
395963002945	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
395963002946	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395963002947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395963002948	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395963002949	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
395963002950	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395963002951	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
395963002952	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
395963002953	aminopeptidase N; Provisional; Region: pepN; PRK14015
395963002954	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
395963002955	active site
395963002956	Zn binding site [ion binding]; other site
395963002957	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395963002958	putative hydrophobic ligand binding site [chemical binding]; other site
395963002959	protein interface [polypeptide binding]; other site
395963002960	gate; other site
395963002961	lysophospholipid transporter LplT; Provisional; Region: PRK11195
395963002962	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395963002963	Cation efflux family; Region: Cation_efflux; cl00316
395963002964	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395963002965	dimer interface [polypeptide binding]; other site
395963002966	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963002967	active site
395963002968	metal binding site [ion binding]; metal-binding site
395963002969	glutathione binding site [chemical binding]; other site
395963002970	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395963002971	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395963002972	substrate binding pocket [chemical binding]; other site
395963002973	chain length determination region; other site
395963002974	substrate-Mg2+ binding site; other site
395963002975	catalytic residues [active]
395963002976	aspartate-rich region 1; other site
395963002977	active site lid residues [active]
395963002978	aspartate-rich region 2; other site
395963002979	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
395963002980	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
395963002981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002982	TPR motif; other site
395963002983	binding surface
395963002984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002985	binding surface
395963002986	TPR motif; other site
395963002987	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395963002988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002989	TPR motif; other site
395963002990	binding surface
395963002991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963002992	binding surface
395963002993	TPR motif; other site
395963002994	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
395963002995	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395963002996	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963002997	N-terminal plug; other site
395963002998	ligand-binding site [chemical binding]; other site
395963002999	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395963003000	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395963003001	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
395963003002	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
395963003003	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395963003004	dimer interface [polypeptide binding]; other site
395963003005	ADP-ribose binding site [chemical binding]; other site
395963003006	active site
395963003007	nudix motif; other site
395963003008	metal binding site [ion binding]; metal-binding site
395963003009	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395963003010	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
395963003011	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395963003012	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395963003013	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
395963003014	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
395963003015	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
395963003016	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
395963003017	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395963003018	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
395963003019	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395963003020	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395963003021	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
395963003022	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395963003023	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395963003024	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
395963003025	IMP binding site; other site
395963003026	dimer interface [polypeptide binding]; other site
395963003027	EcsC protein family; Region: EcsC; pfam12787
395963003028	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
395963003029	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963003030	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963003031	active site
395963003032	catalytic tetrad [active]
395963003033	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
395963003034	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
395963003035	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
395963003036	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395963003037	classical (c) SDRs; Region: SDR_c; cd05233
395963003038	NAD(P) binding site [chemical binding]; other site
395963003039	active site
395963003040	phosphoglycolate phosphatase; Provisional; Region: PRK13222
395963003041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963003042	motif II; other site
395963003043	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
395963003044	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395963003045	active site
395963003046	dimer interface [polypeptide binding]; other site
395963003047	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
395963003048	glutathione reductase; Validated; Region: PRK06116
395963003049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963003050	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963003051	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395963003052	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963003053	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395963003054	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395963003055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395963003056	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963003057	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963003058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395963003059	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395963003060	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395963003061	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
395963003062	substrate binding site [chemical binding]; other site
395963003063	peptide chain release factor 1; Validated; Region: prfA; PRK00591
395963003064	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395963003065	RF-1 domain; Region: RF-1; pfam00472
395963003066	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
395963003067	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395963003068	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
395963003069	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395963003070	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395963003071	aspartate kinase; Reviewed; Region: PRK06635
395963003072	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
395963003073	putative nucleotide binding site [chemical binding]; other site
395963003074	putative catalytic residues [active]
395963003075	putative Mg ion binding site [ion binding]; other site
395963003076	putative aspartate binding site [chemical binding]; other site
395963003077	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
395963003078	putative allosteric regulatory site; other site
395963003079	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
395963003080	Predicted membrane protein [Function unknown]; Region: COG2261
395963003081	Uncharacterized conserved protein [Function unknown]; Region: COG2938
395963003082	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
395963003083	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
395963003084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963003085	ATP binding site [chemical binding]; other site
395963003086	putative Mg++ binding site [ion binding]; other site
395963003087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963003088	nucleotide binding region [chemical binding]; other site
395963003089	ATP-binding site [chemical binding]; other site
395963003090	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
395963003091	AAA domain; Region: AAA_21; pfam13304
395963003092	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
395963003093	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395963003094	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
395963003095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963003096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963003097	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395963003098	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963003099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963003100	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963003101	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395963003102	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963003103	membrane-bound complex binding site; other site
395963003104	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395963003105	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395963003106	FMN binding site [chemical binding]; other site
395963003107	active site
395963003108	substrate binding site [chemical binding]; other site
395963003109	catalytic residue [active]
395963003110	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963003111	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963003112	active site
395963003113	non-prolyl cis peptide bond; other site
395963003114	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
395963003115	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395963003116	aconitate hydratase; Validated; Region: PRK07229
395963003117	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
395963003118	substrate binding site [chemical binding]; other site
395963003119	ligand binding site [chemical binding]; other site
395963003120	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
395963003121	substrate binding site [chemical binding]; other site
395963003122	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395963003123	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
395963003124	putative NAD(P) binding site [chemical binding]; other site
395963003125	putative substrate binding site [chemical binding]; other site
395963003126	catalytic Zn binding site [ion binding]; other site
395963003127	structural Zn binding site [ion binding]; other site
395963003128	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
395963003129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963003130	putative substrate translocation pore; other site
395963003131	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963003132	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963003133	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963003134	active site
395963003135	catalytic tetrad [active]
395963003136	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963003137	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963003138	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963003139	active site
395963003140	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395963003141	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395963003142	active site
395963003143	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
395963003144	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
395963003145	Autoinducer synthetase; Region: Autoind_synth; cl17404
395963003146	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395963003147	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963003148	DNA binding residues [nucleotide binding]
395963003149	dimerization interface [polypeptide binding]; other site
395963003150	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
395963003151	RNA/DNA hybrid binding site [nucleotide binding]; other site
395963003152	active site
395963003153	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
395963003154	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963003155	FeS/SAM binding site; other site
395963003156	salicylate hydroxylase; Provisional; Region: PRK08163
395963003157	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395963003158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
395963003159	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963003160	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963003161	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395963003162	serine acetyltransferase; Provisional; Region: cysE; PRK11132
395963003163	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
395963003164	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395963003165	trimer interface [polypeptide binding]; other site
395963003166	active site
395963003167	substrate binding site [chemical binding]; other site
395963003168	CoA binding site [chemical binding]; other site
395963003169	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
395963003170	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
395963003171	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
395963003172	ornithine decarboxylase; Provisional; Region: PRK13578
395963003173	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963003174	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963003175	catalytic residue [active]
395963003176	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
395963003177	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395963003178	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963003179	Coenzyme A binding pocket [chemical binding]; other site
395963003180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
395963003181	PAS domain; Region: PAS_5; pfam07310
395963003182	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
395963003183	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395963003184	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
395963003185	AMIN domain; Region: AMIN; pfam11741
395963003186	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395963003187	active site
395963003188	metal binding site [ion binding]; metal-binding site
395963003189	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
395963003190	Transglycosylase; Region: Transgly; pfam00912
395963003191	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395963003192	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
395963003193	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963003194	motif II; other site
395963003195	Protein of unknown function, DUF399; Region: DUF399; cl01139
395963003196	Erythromycin esterase; Region: Erythro_esteras; pfam05139
395963003197	peptide chain release factor 2; Validated; Region: prfB; PRK00578
395963003198	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395963003199	RF-1 domain; Region: RF-1; pfam00472
395963003200	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
395963003201	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
395963003202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963003203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963003204	Walker A/P-loop; other site
395963003205	ATP binding site [chemical binding]; other site
395963003206	Q-loop/lid; other site
395963003207	ABC transporter signature motif; other site
395963003208	Walker B; other site
395963003209	D-loop; other site
395963003210	H-loop/switch region; other site
395963003211	Predicted periplasmic protein [Function unknown]; Region: COG3698
395963003212	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
395963003213	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963003214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963003215	non-specific DNA binding site [nucleotide binding]; other site
395963003216	salt bridge; other site
395963003217	sequence-specific DNA binding site [nucleotide binding]; other site
395963003218	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
395963003219	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395963003220	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
395963003221	dimerization interface [polypeptide binding]; other site
395963003222	active site
395963003223	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
395963003224	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395963003225	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
395963003226	putative active site [active]
395963003227	Zn binding site [ion binding]; other site
395963003228	phosphodiesterase YaeI; Provisional; Region: PRK11340
395963003229	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
395963003230	putative active site [active]
395963003231	putative metal binding site [ion binding]; other site
395963003232	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
395963003233	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
395963003234	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
395963003235	NADP binding site [chemical binding]; other site
395963003236	dimer interface [polypeptide binding]; other site
395963003237	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
395963003238	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
395963003239	putative NAD(P) binding site [chemical binding]; other site
395963003240	dimer interface [polypeptide binding]; other site
395963003241	Predicted transcriptional regulators [Transcription]; Region: COG1733
395963003242	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395963003243	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963003244	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963003245	dimerization interface [polypeptide binding]; other site
395963003246	putative DNA binding site [nucleotide binding]; other site
395963003247	putative Zn2+ binding site [ion binding]; other site
395963003248	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395963003249	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
395963003250	putative ion selectivity filter; other site
395963003251	putative pore gating glutamate residue; other site
395963003252	putative H+/Cl- coupling transport residue; other site
395963003253	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963003254	active site
395963003255	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395963003256	Protein of unknown function DUF72; Region: DUF72; pfam01904
395963003257	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395963003258	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395963003259	FMN binding site [chemical binding]; other site
395963003260	active site
395963003261	substrate binding site [chemical binding]; other site
395963003262	catalytic residue [active]
395963003263	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963003264	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963003265	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963003266	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963003267	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963003268	Ligand Binding Site [chemical binding]; other site
395963003269	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963003270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963003271	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963003272	putative effector binding pocket; other site
395963003273	dimerization interface [polypeptide binding]; other site
395963003274	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395963003275	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395963003276	Trp docking motif [polypeptide binding]; other site
395963003277	active site
395963003278	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395963003279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963003280	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963003281	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
395963003282	active site
395963003283	catalytic site [active]
395963003284	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
395963003285	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
395963003286	dimer interface [polypeptide binding]; other site
395963003287	active site
395963003288	heme binding site [chemical binding]; other site
395963003289	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
395963003290	Response regulator receiver domain; Region: Response_reg; pfam00072
395963003291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963003292	active site
395963003293	phosphorylation site [posttranslational modification]
395963003294	intermolecular recognition site; other site
395963003295	dimerization interface [polypeptide binding]; other site
395963003296	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963003297	DNA binding residues [nucleotide binding]
395963003298	dimerization interface [polypeptide binding]; other site
395963003299	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395963003300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963003301	dimer interface [polypeptide binding]; other site
395963003302	phosphorylation site [posttranslational modification]
395963003303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963003304	ATP binding site [chemical binding]; other site
395963003305	Mg2+ binding site [ion binding]; other site
395963003306	G-X-G motif; other site
395963003307	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963003308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963003309	active site
395963003310	phosphorylation site [posttranslational modification]
395963003311	intermolecular recognition site; other site
395963003312	dimerization interface [polypeptide binding]; other site
395963003313	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395963003314	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
395963003315	putative ligand binding site [chemical binding]; other site
395963003316	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395963003317	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395963003318	TM-ABC transporter signature motif; other site
395963003319	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395963003320	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395963003321	TM-ABC transporter signature motif; other site
395963003322	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
395963003323	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395963003324	Walker A/P-loop; other site
395963003325	ATP binding site [chemical binding]; other site
395963003326	Q-loop/lid; other site
395963003327	ABC transporter signature motif; other site
395963003328	Walker B; other site
395963003329	D-loop; other site
395963003330	H-loop/switch region; other site
395963003331	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395963003332	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395963003333	Walker A/P-loop; other site
395963003334	ATP binding site [chemical binding]; other site
395963003335	Q-loop/lid; other site
395963003336	ABC transporter signature motif; other site
395963003337	Walker B; other site
395963003338	D-loop; other site
395963003339	H-loop/switch region; other site
395963003340	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
395963003341	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
395963003342	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963003343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963003344	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963003345	dimerization interface [polypeptide binding]; other site
395963003346	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
395963003347	Cupin; Region: Cupin_1; smart00835
395963003348	Cupin; Region: Cupin_1; smart00835
395963003349	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963003350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963003351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963003352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963003353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395963003354	dimerization interface [polypeptide binding]; other site
395963003355	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
395963003356	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
395963003357	putative dimer interface [polypeptide binding]; other site
395963003358	[2Fe-2S] cluster binding site [ion binding]; other site
395963003359	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
395963003360	putative dimer interface [polypeptide binding]; other site
395963003361	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
395963003362	SLBB domain; Region: SLBB; pfam10531
395963003363	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395963003364	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
395963003365	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963003366	catalytic loop [active]
395963003367	iron binding site [ion binding]; other site
395963003368	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395963003369	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
395963003370	[4Fe-4S] binding site [ion binding]; other site
395963003371	molybdopterin cofactor binding site; other site
395963003372	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
395963003373	molybdopterin cofactor binding site; other site
395963003374	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
395963003375	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395963003376	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395963003377	dimer interface [polypeptide binding]; other site
395963003378	putative functional site; other site
395963003379	putative MPT binding site; other site
395963003380	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
395963003381	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
395963003382	GTP binding site; other site
395963003383	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
395963003384	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963003385	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395963003386	active site
395963003387	metal binding site [ion binding]; metal-binding site
395963003388	hypothetical protein; Validated; Region: PRK00029
395963003389	Uncharacterized conserved protein [Function unknown]; Region: COG0397
395963003390	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
395963003391	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395963003392	FMN binding site [chemical binding]; other site
395963003393	active site
395963003394	catalytic residues [active]
395963003395	substrate binding site [chemical binding]; other site
395963003396	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
395963003397	Protein of unknown function (DUF815); Region: DUF815; pfam05673
395963003398	Preprotein translocase subunit; Region: YajC; pfam02699
395963003399	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
395963003400	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395963003401	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
395963003402	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
395963003403	Protein export membrane protein; Region: SecD_SecF; pfam02355
395963003404	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
395963003405	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
395963003406	substrate binding pocket [chemical binding]; other site
395963003407	substrate-Mg2+ binding site; other site
395963003408	aspartate-rich region 1; other site
395963003409	aspartate-rich region 2; other site
395963003410	AAA ATPase domain; Region: AAA_16; pfam13191
395963003411	Archaeal ATPase; Region: Arch_ATPase; pfam01637
395963003412	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
395963003413	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395963003414	active site
395963003415	HIGH motif; other site
395963003416	nucleotide binding site [chemical binding]; other site
395963003417	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395963003418	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
395963003419	active site
395963003420	KMSKS motif; other site
395963003421	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
395963003422	tRNA binding surface [nucleotide binding]; other site
395963003423	anticodon binding site; other site
395963003424	lipoprotein signal peptidase; Provisional; Region: PRK14796
395963003425	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395963003426	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395963003427	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395963003428	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395963003429	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395963003430	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
395963003431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963003432	ATP binding site [chemical binding]; other site
395963003433	Mg2+ binding site [ion binding]; other site
395963003434	G-X-G motif; other site
395963003435	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
395963003436	ATP binding site [chemical binding]; other site
395963003437	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
395963003438	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
395963003439	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
395963003440	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395963003441	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
395963003442	Predicted transcriptional regulators [Transcription]; Region: COG1733
395963003443	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963003444	putative DNA binding site [nucleotide binding]; other site
395963003445	putative Zn2+ binding site [ion binding]; other site
395963003446	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
395963003447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963003448	NAD(P) binding site [chemical binding]; other site
395963003449	active site
395963003450	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
395963003451	ArsC family; Region: ArsC; pfam03960
395963003452	putative catalytic residues [active]
395963003453	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395963003454	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395963003455	putative dimer interface [polypeptide binding]; other site
395963003456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
395963003457	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395963003458	active site
395963003459	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
395963003460	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
395963003461	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
395963003462	substrate binding site [chemical binding]; other site
395963003463	hexamer interface [polypeptide binding]; other site
395963003464	metal binding site [ion binding]; metal-binding site
395963003465	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
395963003466	short chain dehydrogenase; Provisional; Region: PRK07102
395963003467	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395963003468	NAD(P) binding site [chemical binding]; other site
395963003469	active site
395963003470	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395963003471	FAD binding domain; Region: FAD_binding_4; pfam01565
395963003472	GtrA-like protein; Region: GtrA; pfam04138
395963003473	hypothetical protein; Validated; Region: PRK08238
395963003474	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395963003475	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
395963003476	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
395963003477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963003478	active site
395963003479	motif I; other site
395963003480	motif II; other site
395963003481	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
395963003482	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
395963003483	putative ribose interaction site [chemical binding]; other site
395963003484	putative ADP binding site [chemical binding]; other site
395963003485	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
395963003486	active site
395963003487	HIGH motif; other site
395963003488	nucleotide binding site [chemical binding]; other site
395963003489	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
395963003490	dimerization interface [polypeptide binding]; other site
395963003491	putative active cleft [active]
395963003492	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
395963003493	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395963003494	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395963003495	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395963003496	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
395963003497	intersubunit interface [polypeptide binding]; other site
395963003498	active site
395963003499	Zn2+ binding site [ion binding]; other site
395963003500	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
395963003501	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
395963003502	trimer interface [polypeptide binding]; other site
395963003503	active site
395963003504	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
395963003505	trimer interface [polypeptide binding]; other site
395963003506	active site
395963003507	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
395963003508	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395963003509	homodimer interface [polypeptide binding]; other site
395963003510	substrate-cofactor binding pocket; other site
395963003511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963003512	catalytic residue [active]
395963003513	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
395963003514	acetylornithine deacetylase; Provisional; Region: PRK07522
395963003515	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
395963003516	metal binding site [ion binding]; metal-binding site
395963003517	putative dimer interface [polypeptide binding]; other site
395963003518	urease subunit alpha; Reviewed; Region: ureC; PRK13207
395963003519	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
395963003520	subunit interactions [polypeptide binding]; other site
395963003521	active site
395963003522	flap region; other site
395963003523	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
395963003524	PemK-like protein; Region: PemK; pfam02452
395963003525	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395963003526	active site
395963003527	NTP binding site [chemical binding]; other site
395963003528	metal binding triad [ion binding]; metal-binding site
395963003529	antibiotic binding site [chemical binding]; other site
395963003530	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
395963003531	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
395963003532	RNA binding site [nucleotide binding]; other site
395963003533	active site
395963003534	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
395963003535	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
395963003536	translation initiation factor IF-2; Validated; Region: infB; PRK05306
395963003537	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
395963003538	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
395963003539	G1 box; other site
395963003540	putative GEF interaction site [polypeptide binding]; other site
395963003541	GTP/Mg2+ binding site [chemical binding]; other site
395963003542	Switch I region; other site
395963003543	G2 box; other site
395963003544	G3 box; other site
395963003545	Switch II region; other site
395963003546	G4 box; other site
395963003547	G5 box; other site
395963003548	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
395963003549	Translation-initiation factor 2; Region: IF-2; pfam11987
395963003550	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
395963003551	hypothetical protein; Provisional; Region: PRK09190
395963003552	Protein of unknown function (DUF448); Region: DUF448; pfam04296
395963003553	putative RNA binding cleft [nucleotide binding]; other site
395963003554	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
395963003555	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
395963003556	NusA N-terminal domain; Region: NusA_N; pfam08529
395963003557	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
395963003558	RNA binding site [nucleotide binding]; other site
395963003559	homodimer interface [polypeptide binding]; other site
395963003560	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395963003561	G-X-X-G motif; other site
395963003562	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395963003563	G-X-X-G motif; other site
395963003564	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
395963003565	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
395963003566	Sm and related proteins; Region: Sm_like; cl00259
395963003567	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
395963003568	putative oligomer interface [polypeptide binding]; other site
395963003569	putative RNA binding site [nucleotide binding]; other site
395963003570	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
395963003571	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
395963003572	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
395963003573	Glycoprotease family; Region: Peptidase_M22; pfam00814
395963003574	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395963003575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963003576	Coenzyme A binding pocket [chemical binding]; other site
395963003577	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395963003578	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395963003579	catalytic triad [active]
395963003580	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
395963003581	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395963003582	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963003583	FeS/SAM binding site; other site
395963003584	TRAM domain; Region: TRAM; cl01282
395963003585	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
395963003586	PhoH-like protein; Region: PhoH; pfam02562
395963003587	metal-binding heat shock protein; Provisional; Region: PRK00016
395963003588	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
395963003589	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395963003590	Transporter associated domain; Region: CorC_HlyC; smart01091
395963003591	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
395963003592	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
395963003593	putative active site [active]
395963003594	catalytic triad [active]
395963003595	putative dimer interface [polypeptide binding]; other site
395963003596	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963003597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963003598	non-specific DNA binding site [nucleotide binding]; other site
395963003599	salt bridge; other site
395963003600	sequence-specific DNA binding site [nucleotide binding]; other site
395963003601	S-adenosylmethionine synthetase; Validated; Region: PRK05250
395963003602	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
395963003603	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
395963003604	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
395963003605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963003606	S-adenosylmethionine binding site [chemical binding]; other site
395963003607	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
395963003608	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963003609	DXD motif; other site
395963003610	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
395963003611	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395963003612	active site
395963003613	nucleotide binding site [chemical binding]; other site
395963003614	HIGH motif; other site
395963003615	KMSKS motif; other site
395963003616	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
395963003617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
395963003618	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
395963003619	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
395963003620	quinone interaction residues [chemical binding]; other site
395963003621	active site
395963003622	catalytic residues [active]
395963003623	FMN binding site [chemical binding]; other site
395963003624	substrate binding site [chemical binding]; other site
395963003625	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
395963003626	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
395963003627	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
395963003628	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
395963003629	active site
395963003630	DNA binding site [nucleotide binding]
395963003631	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
395963003632	DNA binding site [nucleotide binding]
395963003633	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
395963003634	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963003635	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
395963003636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395963003637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963003638	S-adenosylmethionine binding site [chemical binding]; other site
395963003639	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395963003640	ABC1 family; Region: ABC1; cl17513
395963003641	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
395963003642	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
395963003643	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963003644	Coenzyme A binding pocket [chemical binding]; other site
395963003645	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
395963003646	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
395963003647	active site
395963003648	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395963003649	dimer interface [polypeptide binding]; other site
395963003650	catalytic residues [active]
395963003651	substrate binding site [chemical binding]; other site
395963003652	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
395963003653	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395963003654	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395963003655	Creatinine amidohydrolase; Region: Creatininase; pfam02633
395963003656	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
395963003657	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
395963003658	NMT1/THI5 like; Region: NMT1; pfam09084
395963003659	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395963003660	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963003661	Walker A/P-loop; other site
395963003662	ATP binding site [chemical binding]; other site
395963003663	Q-loop/lid; other site
395963003664	ABC transporter signature motif; other site
395963003665	Walker B; other site
395963003666	D-loop; other site
395963003667	H-loop/switch region; other site
395963003668	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963003669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395963003670	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
395963003671	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395963003672	putative ligand binding site [chemical binding]; other site
395963003673	NAD binding site [chemical binding]; other site
395963003674	catalytic site [active]
395963003675	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
395963003676	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395963003677	DNA binding residues [nucleotide binding]
395963003678	putative dimer interface [polypeptide binding]; other site
395963003679	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395963003680	Sel1-like repeats; Region: SEL1; smart00671
395963003681	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
395963003682	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
395963003683	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963003684	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395963003685	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
395963003686	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
395963003687	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
395963003688	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
395963003689	Ligand Binding Site [chemical binding]; other site
395963003690	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395963003691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963003692	dimer interface [polypeptide binding]; other site
395963003693	phosphorylation site [posttranslational modification]
395963003694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963003695	ATP binding site [chemical binding]; other site
395963003696	Mg2+ binding site [ion binding]; other site
395963003697	G-X-G motif; other site
395963003698	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
395963003699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963003700	active site
395963003701	phosphorylation site [posttranslational modification]
395963003702	intermolecular recognition site; other site
395963003703	dimerization interface [polypeptide binding]; other site
395963003704	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963003705	DNA binding site [nucleotide binding]
395963003706	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395963003707	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
395963003708	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395963003709	acyl-activating enzyme (AAE) consensus motif; other site
395963003710	AMP binding site [chemical binding]; other site
395963003711	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395963003712	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
395963003713	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395963003714	putative trimer interface [polypeptide binding]; other site
395963003715	putative CoA binding site [chemical binding]; other site
395963003716	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395963003717	putative trimer interface [polypeptide binding]; other site
395963003718	putative CoA binding site [chemical binding]; other site
395963003719	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395963003720	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
395963003721	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395963003722	NAD binding site [chemical binding]; other site
395963003723	homotetramer interface [polypeptide binding]; other site
395963003724	homodimer interface [polypeptide binding]; other site
395963003725	substrate binding site [chemical binding]; other site
395963003726	active site
395963003727	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
395963003728	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
395963003729	DNA binding residues [nucleotide binding]
395963003730	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395963003731	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
395963003732	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395963003733	HSP70 interaction site [polypeptide binding]; other site
395963003734	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395963003735	substrate binding site [polypeptide binding]; other site
395963003736	dimer interface [polypeptide binding]; other site
395963003737	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
395963003738	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395963003739	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
395963003740	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395963003741	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395963003742	substrate-cofactor binding pocket; other site
395963003743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963003744	catalytic residue [active]
395963003745	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
395963003746	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395963003747	active site
395963003748	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395963003749	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
395963003750	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
395963003751	Enoylreductase; Region: PKS_ER; smart00829
395963003752	NAD(P) binding site [chemical binding]; other site
395963003753	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
395963003754	KR domain; Region: KR; pfam08659
395963003755	putative NADP binding site [chemical binding]; other site
395963003756	active site
395963003757	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
395963003758	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963003759	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395963003760	C-terminal domain interface [polypeptide binding]; other site
395963003761	GSH binding site (G-site) [chemical binding]; other site
395963003762	dimer interface [polypeptide binding]; other site
395963003763	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
395963003764	N-terminal domain interface [polypeptide binding]; other site
395963003765	dimer interface [polypeptide binding]; other site
395963003766	substrate binding pocket (H-site) [chemical binding]; other site
395963003767	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
395963003768	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
395963003769	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
395963003770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963003771	Walker A/P-loop; other site
395963003772	ATP binding site [chemical binding]; other site
395963003773	Q-loop/lid; other site
395963003774	ABC transporter signature motif; other site
395963003775	Walker B; other site
395963003776	D-loop; other site
395963003777	H-loop/switch region; other site
395963003778	ABC transporter; Region: ABC_tran_2; pfam12848
395963003779	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963003780	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395963003781	active site
395963003782	oxyanion hole [active]
395963003783	catalytic triad [active]
395963003784	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
395963003785	active site
395963003786	SUMO-1 interface [polypeptide binding]; other site
395963003787	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963003788	putative DNA binding site [nucleotide binding]; other site
395963003789	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395963003790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963003791	S-adenosylmethionine binding site [chemical binding]; other site
395963003792	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
395963003793	FAD binding site [chemical binding]; other site
395963003794	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
395963003795	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
395963003796	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
395963003797	substrate binding pocket [chemical binding]; other site
395963003798	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
395963003799	B12 binding site [chemical binding]; other site
395963003800	cobalt ligand [ion binding]; other site
395963003801	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
395963003802	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
395963003803	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395963003804	classical (c) SDRs; Region: SDR_c; cd05233
395963003805	NAD(P) binding site [chemical binding]; other site
395963003806	active site
395963003807	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
395963003808	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
395963003809	putative MPT binding site; other site
395963003810	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963003811	active site
395963003812	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
395963003813	isocitrate dehydrogenase; Validated; Region: PRK08299
395963003814	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395963003815	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395963003816	active site
395963003817	metal binding site [ion binding]; metal-binding site
395963003818	Chain length determinant protein; Region: Wzz; cl15801
395963003819	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395963003820	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
395963003821	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963003822	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963003823	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
395963003824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963003825	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
395963003826	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395963003827	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395963003828	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
395963003829	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395963003830	glutamine binding [chemical binding]; other site
395963003831	catalytic triad [active]
395963003832	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
395963003833	substrate-cofactor binding pocket; other site
395963003834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963003835	homodimer interface [polypeptide binding]; other site
395963003836	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395963003837	catalytic residue [active]
395963003838	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
395963003839	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963003840	active site
395963003841	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
395963003842	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
395963003843	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395963003844	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
395963003845	putative NAD(P) binding site [chemical binding]; other site
395963003846	putative substrate binding site [chemical binding]; other site
395963003847	catalytic Zn binding site [ion binding]; other site
395963003848	structural Zn binding site [ion binding]; other site
395963003849	dimer interface [polypeptide binding]; other site
395963003850	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395963003851	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963003852	putative active site [active]
395963003853	heme pocket [chemical binding]; other site
395963003854	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395963003855	dimer interface [polypeptide binding]; other site
395963003856	phosphorylation site [posttranslational modification]
395963003857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963003858	ATP binding site [chemical binding]; other site
395963003859	Mg2+ binding site [ion binding]; other site
395963003860	G-X-G motif; other site
395963003861	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395963003862	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
395963003863	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
395963003864	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
395963003865	Acylphosphatase; Region: Acylphosphatase; pfam00708
395963003866	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
395963003867	HypF finger; Region: zf-HYPF; pfam07503
395963003868	HypF finger; Region: zf-HYPF; pfam07503
395963003869	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
395963003870	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
395963003871	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
395963003872	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395963003873	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
395963003874	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
395963003875	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395963003876	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
395963003877	putative substrate-binding site; other site
395963003878	nickel binding site [ion binding]; other site
395963003879	HupF/HypC family; Region: HupF_HypC; pfam01455
395963003880	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
395963003881	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
395963003882	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
395963003883	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
395963003884	Rubredoxin; Region: Rubredoxin; pfam00301
395963003885	iron binding site [ion binding]; other site
395963003886	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
395963003887	coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295
395963003888	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
395963003889	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
395963003890	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963003891	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395963003892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963003893	active site
395963003894	phosphorylation site [posttranslational modification]
395963003895	intermolecular recognition site; other site
395963003896	dimerization interface [polypeptide binding]; other site
395963003897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963003898	Walker A motif; other site
395963003899	ATP binding site [chemical binding]; other site
395963003900	Walker B motif; other site
395963003901	arginine finger; other site
395963003902	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963003903	HupF/HypC family; Region: HupF_HypC; cl00394
395963003904	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
395963003905	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
395963003906	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
395963003907	dimerization interface [polypeptide binding]; other site
395963003908	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
395963003909	ATP binding site [chemical binding]; other site
395963003910	Phosphoesterase family; Region: Phosphoesterase; pfam04185
395963003911	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963003912	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963003913	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
395963003914	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
395963003915	Protein export membrane protein; Region: SecD_SecF; cl14618
395963003916	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
395963003917	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963003918	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963003919	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395963003920	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395963003921	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
395963003922	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963003923	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963003924	active site
395963003925	non-prolyl cis peptide bond; other site
395963003926	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
395963003927	HD domain; Region: HD_3; cl17350
395963003928	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395963003929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963003930	Walker A motif; other site
395963003931	ATP binding site [chemical binding]; other site
395963003932	Walker B motif; other site
395963003933	arginine finger; other site
395963003934	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
395963003935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963003936	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963003937	putative substrate translocation pore; other site
395963003938	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395963003939	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395963003940	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395963003941	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395963003942	ligand binding site [chemical binding]; other site
395963003943	flexible hinge region; other site
395963003944	heme exporter protein CcmB; Region: ccmB; TIGR01190
395963003945	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
395963003946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963003947	Walker A/P-loop; other site
395963003948	ATP binding site [chemical binding]; other site
395963003949	Q-loop/lid; other site
395963003950	ABC transporter signature motif; other site
395963003951	Walker B; other site
395963003952	D-loop; other site
395963003953	H-loop/switch region; other site
395963003954	aconitate hydratase; Validated; Region: PRK09277
395963003955	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
395963003956	substrate binding site [chemical binding]; other site
395963003957	ligand binding site [chemical binding]; other site
395963003958	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
395963003959	substrate binding site [chemical binding]; other site
395963003960	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
395963003961	tartrate dehydrogenase; Region: TTC; TIGR02089
395963003962	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395963003963	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963003964	N-terminal plug; other site
395963003965	ligand-binding site [chemical binding]; other site
395963003966	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
395963003967	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395963003968	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395963003969	active site clefts [active]
395963003970	zinc binding site [ion binding]; other site
395963003971	dimer interface [polypeptide binding]; other site
395963003972	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395963003973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
395963003974	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
395963003975	HemY protein N-terminus; Region: HemY_N; pfam07219
395963003976	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
395963003977	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
395963003978	Substrate binding site; other site
395963003979	Cupin domain; Region: Cupin_2; cl17218
395963003980	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
395963003981	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
395963003982	G1 box; other site
395963003983	putative GEF interaction site [polypeptide binding]; other site
395963003984	GTP/Mg2+ binding site [chemical binding]; other site
395963003985	Switch I region; other site
395963003986	G2 box; other site
395963003987	G3 box; other site
395963003988	Switch II region; other site
395963003989	G4 box; other site
395963003990	G5 box; other site
395963003991	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
395963003992	Predicted integral membrane protein [Function unknown]; Region: COG5473
395963003993	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
395963003994	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
395963003995	BON domain; Region: BON; pfam04972
395963003996	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395963003997	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395963003998	ligand binding site [chemical binding]; other site
395963003999	Uncharacterized conserved protein [Function unknown]; Region: COG3743
395963004000	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963004001	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963004002	active site
395963004003	catalytic tetrad [active]
395963004004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004006	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963004007	dimerization interface [polypeptide binding]; other site
395963004008	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395963004009	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395963004010	Trp docking motif [polypeptide binding]; other site
395963004011	active site
395963004012	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963004013	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963004014	active site
395963004015	nucleophile elbow; other site
395963004016	Domain of unknown function (DUF378); Region: DUF378; pfam04070
395963004017	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
395963004018	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
395963004019	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
395963004020	RDD family; Region: RDD; pfam06271
395963004021	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
395963004022	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
395963004023	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
395963004024	dimer interface [polypeptide binding]; other site
395963004025	allosteric magnesium binding site [ion binding]; other site
395963004026	active site
395963004027	aspartate-rich active site metal binding site; other site
395963004028	Schiff base residues; other site
395963004029	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
395963004030	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395963004031	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395963004032	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395963004033	putative dimer interface [polypeptide binding]; other site
395963004034	N-terminal domain interface [polypeptide binding]; other site
395963004035	putative substrate binding pocket (H-site) [chemical binding]; other site
395963004036	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
395963004037	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963004038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004039	active site
395963004040	phosphorylation site [posttranslational modification]
395963004041	intermolecular recognition site; other site
395963004042	dimerization interface [polypeptide binding]; other site
395963004043	response regulator PleD; Reviewed; Region: pleD; PRK09581
395963004044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004045	active site
395963004046	phosphorylation site [posttranslational modification]
395963004047	intermolecular recognition site; other site
395963004048	dimerization interface [polypeptide binding]; other site
395963004049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004050	active site
395963004051	phosphorylation site [posttranslational modification]
395963004052	intermolecular recognition site; other site
395963004053	dimerization interface [polypeptide binding]; other site
395963004054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395963004055	metal binding site [ion binding]; metal-binding site
395963004056	active site
395963004057	I-site; other site
395963004058	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395963004059	Beta-lactamase; Region: Beta-lactamase; pfam00144
395963004060	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
395963004061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963004062	Mg2+ binding site [ion binding]; other site
395963004063	G-X-G motif; other site
395963004064	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395963004065	anchoring element; other site
395963004066	dimer interface [polypeptide binding]; other site
395963004067	ATP binding site [chemical binding]; other site
395963004068	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
395963004069	active site
395963004070	metal binding site [ion binding]; metal-binding site
395963004071	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395963004072	glutamine synthetase; Provisional; Region: glnA; PRK09469
395963004073	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395963004074	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395963004075	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395963004076	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395963004077	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
395963004078	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395963004079	active site residue [active]
395963004080	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395963004081	active site residue [active]
395963004082	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395963004083	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395963004084	dimer interface [polypeptide binding]; other site
395963004085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963004086	catalytic residue [active]
395963004087	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
395963004088	30S subunit binding site; other site
395963004089	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395963004090	RNA binding site [nucleotide binding]; other site
395963004091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963004092	short chain dehydrogenase; Provisional; Region: PRK07024
395963004093	NAD(P) binding site [chemical binding]; other site
395963004094	active site
395963004095	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963004096	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963004097	active site
395963004098	non-prolyl cis peptide bond; other site
395963004099	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
395963004100	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
395963004101	dimer interface [polypeptide binding]; other site
395963004102	active site
395963004103	glycine-pyridoxal phosphate binding site [chemical binding]; other site
395963004104	folate binding site [chemical binding]; other site
395963004105	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
395963004106	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
395963004107	catalytic motif [active]
395963004108	Zn binding site [ion binding]; other site
395963004109	RibD C-terminal domain; Region: RibD_C; cl17279
395963004110	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
395963004111	Lumazine binding domain; Region: Lum_binding; pfam00677
395963004112	Lumazine binding domain; Region: Lum_binding; pfam00677
395963004113	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
395963004114	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
395963004115	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
395963004116	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
395963004117	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
395963004118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963004119	putative ADP-binding pocket [chemical binding]; other site
395963004120	FtsH Extracellular; Region: FtsH_ext; pfam06480
395963004121	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
395963004122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963004123	Walker A motif; other site
395963004124	ATP binding site [chemical binding]; other site
395963004125	Walker B motif; other site
395963004126	arginine finger; other site
395963004127	Peptidase family M41; Region: Peptidase_M41; pfam01434
395963004128	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395963004129	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
395963004130	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963004131	catalytic residue [active]
395963004132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963004133	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963004134	putative substrate translocation pore; other site
395963004135	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395963004136	MarR family; Region: MarR; pfam01047
395963004137	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
395963004138	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
395963004139	generic binding surface II; other site
395963004140	generic binding surface I; other site
395963004141	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395963004142	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395963004143	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
395963004144	TrkA-N domain; Region: TrkA_N; pfam02254
395963004145	NnrU protein; Region: NnrU; pfam07298
395963004146	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
395963004147	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
395963004148	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963004149	inhibitor-cofactor binding pocket; inhibition site
395963004150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963004151	catalytic residue [active]
395963004152	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
395963004153	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
395963004154	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
395963004155	NAD(P) binding site [chemical binding]; other site
395963004156	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395963004157	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
395963004158	conserved cys residue [active]
395963004159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963004160	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
395963004161	Isochorismatase family; Region: Isochorismatase; pfam00857
395963004162	catalytic triad [active]
395963004163	conserved cis-peptide bond; other site
395963004164	AAA ATPase domain; Region: AAA_16; pfam13191
395963004165	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395963004166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395963004167	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963004168	binding surface
395963004169	TPR motif; other site
395963004170	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395963004171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963004172	binding surface
395963004173	TPR motif; other site
395963004174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
395963004175	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
395963004176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963004177	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963004178	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395963004179	META domain; Region: META; pfam03724
395963004180	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
395963004181	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
395963004182	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963004183	RNA binding surface [nucleotide binding]; other site
395963004184	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963004185	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963004186	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
395963004187	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395963004188	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
395963004189	Protein of unknown function DUF45; Region: DUF45; pfam01863
395963004190	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
395963004191	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963004192	ATP binding site [chemical binding]; other site
395963004193	putative Mg++ binding site [ion binding]; other site
395963004194	nucleotide binding region [chemical binding]; other site
395963004195	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395963004196	Helicase associated domain (HA2); Region: HA2; pfam04408
395963004197	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
395963004198	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395963004199	potassium uptake protein; Region: kup; TIGR00794
395963004200	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
395963004201	MutS domain I; Region: MutS_I; pfam01624
395963004202	MutS domain II; Region: MutS_II; pfam05188
395963004203	MutS domain III; Region: MutS_III; pfam05192
395963004204	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
395963004205	Walker A/P-loop; other site
395963004206	ATP binding site [chemical binding]; other site
395963004207	Q-loop/lid; other site
395963004208	ABC transporter signature motif; other site
395963004209	Walker B; other site
395963004210	D-loop; other site
395963004211	H-loop/switch region; other site
395963004212	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395963004213	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395963004214	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395963004215	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395963004216	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395963004217	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
395963004218	Response regulator receiver domain; Region: Response_reg; pfam00072
395963004219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004220	active site
395963004221	phosphorylation site [posttranslational modification]
395963004222	intermolecular recognition site; other site
395963004223	dimerization interface [polypeptide binding]; other site
395963004224	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
395963004225	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
395963004226	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395963004227	ligand binding site [chemical binding]; other site
395963004228	NAD binding site [chemical binding]; other site
395963004229	dimerization interface [polypeptide binding]; other site
395963004230	catalytic site [active]
395963004231	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
395963004232	putative L-serine binding site [chemical binding]; other site
395963004233	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
395963004234	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963004235	catalytic residue [active]
395963004236	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
395963004237	putative heme binding pocket [chemical binding]; other site
395963004238	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395963004239	argininosuccinate synthase; Provisional; Region: PRK13820
395963004240	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
395963004241	ANP binding site [chemical binding]; other site
395963004242	Substrate Binding Site II [chemical binding]; other site
395963004243	Substrate Binding Site I [chemical binding]; other site
395963004244	SWI complex, BAF60b domains; Region: SWIB; smart00151
395963004245	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963004246	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963004247	active site
395963004248	catalytic tetrad [active]
395963004249	short chain dehydrogenase; Provisional; Region: PRK06500
395963004250	classical (c) SDRs; Region: SDR_c; cd05233
395963004251	NAD(P) binding site [chemical binding]; other site
395963004252	active site
395963004253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004255	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963004256	putative effector binding pocket; other site
395963004257	dimerization interface [polypeptide binding]; other site
395963004258	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963004259	dimerization interface [polypeptide binding]; other site
395963004260	putative Zn2+ binding site [ion binding]; other site
395963004261	putative DNA binding site [nucleotide binding]; other site
395963004262	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395963004263	active site residue [active]
395963004264	Short C-terminal domain; Region: SHOCT; pfam09851
395963004265	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
395963004266	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
395963004267	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
395963004268	catalytic residues [active]
395963004269	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
395963004270	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
395963004271	trmE is a tRNA modification GTPase; Region: trmE; cd04164
395963004272	G1 box; other site
395963004273	GTP/Mg2+ binding site [chemical binding]; other site
395963004274	Switch I region; other site
395963004275	G2 box; other site
395963004276	Switch II region; other site
395963004277	G3 box; other site
395963004278	G4 box; other site
395963004279	G5 box; other site
395963004280	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
395963004281	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
395963004282	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395963004283	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
395963004284	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
395963004285	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
395963004286	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
395963004287	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
395963004288	purine monophosphate binding site [chemical binding]; other site
395963004289	dimer interface [polypeptide binding]; other site
395963004290	putative catalytic residues [active]
395963004291	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
395963004292	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
395963004293	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
395963004294	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
395963004295	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
395963004296	catalytic site [active]
395963004297	G-X2-G-X-G-K; other site
395963004298	hypothetical protein; Provisional; Region: PRK11820
395963004299	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
395963004300	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
395963004301	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
395963004302	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
395963004303	active site
395963004304	cosubstrate binding site; other site
395963004305	substrate binding site [chemical binding]; other site
395963004306	catalytic site [active]
395963004307	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
395963004308	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
395963004309	dimerization interface [polypeptide binding]; other site
395963004310	putative ATP binding site [chemical binding]; other site
395963004311	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004313	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963004314	putative effector binding pocket; other site
395963004315	dimerization interface [polypeptide binding]; other site
395963004316	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
395963004317	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395963004318	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395963004319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395963004320	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
395963004321	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
395963004322	hypothetical protein; Validated; Region: PRK07581
395963004323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963004324	S-adenosylmethionine binding site [chemical binding]; other site
395963004325	amidase; Provisional; Region: PRK06170
395963004326	Amidase; Region: Amidase; cl11426
395963004327	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963004328	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
395963004329	active site
395963004330	metal binding site [ion binding]; metal-binding site
395963004331	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395963004332	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
395963004333	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395963004334	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
395963004335	putative NAD(P) binding site [chemical binding]; other site
395963004336	active site
395963004337	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
395963004338	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963004339	motif II; other site
395963004340	camphor resistance protein CrcB; Provisional; Region: PRK14198
395963004341	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395963004342	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963004343	RNA binding surface [nucleotide binding]; other site
395963004344	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395963004345	active site
395963004346	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395963004347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963004348	motif II; other site
395963004349	ATP12 chaperone protein; Region: ATP12; cl02228
395963004350	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
395963004351	catalytic residues [active]
395963004352	dimer interface [polypeptide binding]; other site
395963004353	putative acetyltransferase YhhY; Provisional; Region: PRK10140
395963004354	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395963004355	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
395963004356	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395963004357	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
395963004358	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
395963004359	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395963004360	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395963004361	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395963004362	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395963004363	carboxyltransferase (CT) interaction site; other site
395963004364	biotinylation site [posttranslational modification]; other site
395963004365	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
395963004366	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
395963004367	substrate binding [chemical binding]; other site
395963004368	active site
395963004369	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
395963004370	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
395963004371	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
395963004372	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
395963004373	generic binding surface II; other site
395963004374	ssDNA binding site; other site
395963004375	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963004376	ATP binding site [chemical binding]; other site
395963004377	putative Mg++ binding site [ion binding]; other site
395963004378	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963004379	nucleotide binding region [chemical binding]; other site
395963004380	ATP-binding site [chemical binding]; other site
395963004381	pantoate--beta-alanine ligase; Region: panC; TIGR00018
395963004382	Pantoate-beta-alanine ligase; Region: PanC; cd00560
395963004383	active site
395963004384	ATP-binding site [chemical binding]; other site
395963004385	pantoate-binding site; other site
395963004386	HXXH motif; other site
395963004387	Acylphosphatase; Region: Acylphosphatase; pfam00708
395963004388	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395963004389	EamA-like transporter family; Region: EamA; cl17759
395963004390	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
395963004391	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
395963004392	glutamate racemase; Provisional; Region: PRK00865
395963004393	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
395963004394	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
395963004395	active site
395963004396	Riboflavin kinase; Region: Flavokinase; smart00904
395963004397	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
395963004398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963004399	active site
395963004400	motif I; other site
395963004401	motif II; other site
395963004402	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395963004403	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395963004404	active site residue [active]
395963004405	Transcriptional activator [Transcription]; Region: ChrR; COG3806
395963004406	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395963004407	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395963004408	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395963004409	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395963004410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963004411	putative substrate translocation pore; other site
395963004412	Protein of unknown function (DUF461); Region: DUF461; pfam04314
395963004413	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
395963004414	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
395963004415	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395963004416	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395963004417	GAF domain; Region: GAF; pfam01590
395963004418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395963004419	HWE histidine kinase; Region: HWE_HK; smart00911
395963004420	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395963004421	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395963004422	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395963004423	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395963004424	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
395963004425	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395963004426	carboxyltransferase (CT) interaction site; other site
395963004427	biotinylation site [posttranslational modification]; other site
395963004428	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
395963004429	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
395963004430	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
395963004431	putative homodimer interface [polypeptide binding]; other site
395963004432	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
395963004433	heterodimer interface [polypeptide binding]; other site
395963004434	homodimer interface [polypeptide binding]; other site
395963004435	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
395963004436	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
395963004437	23S rRNA interface [nucleotide binding]; other site
395963004438	L7/L12 interface [polypeptide binding]; other site
395963004439	putative thiostrepton binding site; other site
395963004440	L25 interface [polypeptide binding]; other site
395963004441	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
395963004442	mRNA/rRNA interface [nucleotide binding]; other site
395963004443	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
395963004444	23S rRNA interface [nucleotide binding]; other site
395963004445	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
395963004446	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
395963004447	L11 interface [polypeptide binding]; other site
395963004448	putative EF-Tu interaction site [polypeptide binding]; other site
395963004449	putative EF-G interaction site [polypeptide binding]; other site
395963004450	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
395963004451	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
395963004452	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
395963004453	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395963004454	RPB11 interaction site [polypeptide binding]; other site
395963004455	RPB12 interaction site [polypeptide binding]; other site
395963004456	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395963004457	RPB3 interaction site [polypeptide binding]; other site
395963004458	RPB1 interaction site [polypeptide binding]; other site
395963004459	RPB11 interaction site [polypeptide binding]; other site
395963004460	RPB10 interaction site [polypeptide binding]; other site
395963004461	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
395963004462	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
395963004463	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
395963004464	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
395963004465	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
395963004466	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395963004467	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
395963004468	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395963004469	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
395963004470	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
395963004471	DNA binding site [nucleotide binding]
395963004472	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
395963004473	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
395963004474	S17 interaction site [polypeptide binding]; other site
395963004475	S8 interaction site; other site
395963004476	16S rRNA interaction site [nucleotide binding]; other site
395963004477	streptomycin interaction site [chemical binding]; other site
395963004478	23S rRNA interaction site [nucleotide binding]; other site
395963004479	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
395963004480	30S ribosomal protein S7; Validated; Region: PRK05302
395963004481	elongation factor G; Reviewed; Region: PRK00007
395963004482	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
395963004483	G1 box; other site
395963004484	putative GEF interaction site [polypeptide binding]; other site
395963004485	GTP/Mg2+ binding site [chemical binding]; other site
395963004486	Switch I region; other site
395963004487	G2 box; other site
395963004488	G3 box; other site
395963004489	Switch II region; other site
395963004490	G4 box; other site
395963004491	G5 box; other site
395963004492	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
395963004493	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395963004494	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395963004495	elongation factor Tu; Reviewed; Region: PRK00049
395963004496	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395963004497	G1 box; other site
395963004498	GEF interaction site [polypeptide binding]; other site
395963004499	GTP/Mg2+ binding site [chemical binding]; other site
395963004500	Switch I region; other site
395963004501	G2 box; other site
395963004502	G3 box; other site
395963004503	Switch II region; other site
395963004504	G4 box; other site
395963004505	G5 box; other site
395963004506	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395963004507	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395963004508	Antibiotic Binding Site [chemical binding]; other site
395963004509	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
395963004510	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
395963004511	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
395963004512	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
395963004513	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
395963004514	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
395963004515	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
395963004516	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
395963004517	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
395963004518	putative translocon binding site; other site
395963004519	protein-rRNA interface [nucleotide binding]; other site
395963004520	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
395963004521	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
395963004522	G-X-X-G motif; other site
395963004523	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
395963004524	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
395963004525	5S rRNA interface [nucleotide binding]; other site
395963004526	23S rRNA interface [nucleotide binding]; other site
395963004527	putative antibiotic binding site [chemical binding]; other site
395963004528	L25 interface [polypeptide binding]; other site
395963004529	L27 interface [polypeptide binding]; other site
395963004530	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
395963004531	putative translocon interaction site; other site
395963004532	signal recognition particle (SRP54) interaction site; other site
395963004533	L23 interface [polypeptide binding]; other site
395963004534	trigger factor interaction site; other site
395963004535	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
395963004536	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
395963004537	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
395963004538	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
395963004539	RNA binding site [nucleotide binding]; other site
395963004540	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
395963004541	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
395963004542	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
395963004543	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
395963004544	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
395963004545	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
395963004546	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395963004547	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395963004548	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
395963004549	5S rRNA interface [nucleotide binding]; other site
395963004550	23S rRNA interface [nucleotide binding]; other site
395963004551	L5 interface [polypeptide binding]; other site
395963004552	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
395963004553	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
395963004554	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
395963004555	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
395963004556	23S rRNA binding site [nucleotide binding]; other site
395963004557	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
395963004558	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
395963004559	SecY translocase; Region: SecY; pfam00344
395963004560	adenylate kinase; Reviewed; Region: adk; PRK00279
395963004561	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
395963004562	AMP-binding site [chemical binding]; other site
395963004563	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
395963004564	Predicted transcriptional regulator [Transcription]; Region: COG1959
395963004565	Transcriptional regulator; Region: Rrf2; pfam02082
395963004566	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
395963004567	23S rRNA interface [nucleotide binding]; other site
395963004568	L3 interface [polypeptide binding]; other site
395963004569	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
395963004570	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
395963004571	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395963004572	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395963004573	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395963004574	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
395963004575	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
395963004576	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395963004577	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395963004578	putative hydrophobic ligand binding site [chemical binding]; other site
395963004579	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
395963004580	Isochorismatase family; Region: Isochorismatase; pfam00857
395963004581	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395963004582	catalytic triad [active]
395963004583	conserved cis-peptide bond; other site
395963004584	homoserine dehydrogenase; Provisional; Region: PRK06349
395963004585	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
395963004586	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
395963004587	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
395963004588	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
395963004589	putative active site [active]
395963004590	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
395963004591	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395963004592	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395963004593	catalytic site [active]
395963004594	putative active site [active]
395963004595	putative substrate binding site [chemical binding]; other site
395963004596	HRDC domain; Region: HRDC; pfam00570
395963004597	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395963004598	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963004599	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963004600	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963004601	YCII-related domain; Region: YCII; cl00999
395963004602	Citrate transporter; Region: CitMHS; pfam03600
395963004603	fructuronate transporter; Provisional; Region: PRK10034; cl15264
395963004604	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
395963004605	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
395963004606	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
395963004607	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
395963004608	dimer interface [polypeptide binding]; other site
395963004609	anticodon binding site; other site
395963004610	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
395963004611	homodimer interface [polypeptide binding]; other site
395963004612	motif 1; other site
395963004613	active site
395963004614	motif 2; other site
395963004615	GAD domain; Region: GAD; pfam02938
395963004616	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395963004617	active site
395963004618	motif 3; other site
395963004619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963004620	non-specific DNA binding site [nucleotide binding]; other site
395963004621	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
395963004622	salt bridge; other site
395963004623	sequence-specific DNA binding site [nucleotide binding]; other site
395963004624	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395963004625	Catalytic site [active]
395963004626	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
395963004627	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963004628	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963004629	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
395963004630	Fusaric acid resistance protein family; Region: FUSC; pfam04632
395963004631	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
395963004632	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
395963004633	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395963004634	putative catalytic site [active]
395963004635	putative phosphate binding site [ion binding]; other site
395963004636	active site
395963004637	metal binding site A [ion binding]; metal-binding site
395963004638	DNA binding site [nucleotide binding]
395963004639	putative AP binding site [nucleotide binding]; other site
395963004640	putative metal binding site B [ion binding]; other site
395963004641	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
395963004642	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395963004643	EamA-like transporter family; Region: EamA; pfam00892
395963004644	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
395963004645	EamA-like transporter family; Region: EamA; pfam00892
395963004646	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
395963004647	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395963004648	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004650	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963004651	putative effector binding pocket; other site
395963004652	dimerization interface [polypeptide binding]; other site
395963004653	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
395963004654	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
395963004655	dimer interface [polypeptide binding]; other site
395963004656	active site
395963004657	citrylCoA binding site [chemical binding]; other site
395963004658	NADH binding [chemical binding]; other site
395963004659	cationic pore residues; other site
395963004660	oxalacetate/citrate binding site [chemical binding]; other site
395963004661	coenzyme A binding site [chemical binding]; other site
395963004662	catalytic triad [active]
395963004663	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
395963004664	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395963004665	active site
395963004666	HIGH motif; other site
395963004667	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395963004668	active site
395963004669	KMSKS motif; other site
395963004670	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
395963004671	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
395963004672	Competence protein; Region: Competence; pfam03772
395963004673	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395963004674	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395963004675	catalytic triad [active]
395963004676	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395963004677	catalytic core [active]
395963004678	Predicted transcriptional regulators [Transcription]; Region: COG1695
395963004679	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395963004680	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395963004681	active site
395963004682	ribulose/triose binding site [chemical binding]; other site
395963004683	phosphate binding site [ion binding]; other site
395963004684	substrate (anthranilate) binding pocket [chemical binding]; other site
395963004685	product (indole) binding pocket [chemical binding]; other site
395963004686	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
395963004687	trimer interface [polypeptide binding]; other site
395963004688	dimer interface [polypeptide binding]; other site
395963004689	putative active site [active]
395963004690	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395963004691	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395963004692	dimer interface [polypeptide binding]; other site
395963004693	putative functional site; other site
395963004694	putative MPT binding site; other site
395963004695	LexA repressor; Validated; Region: PRK00215
395963004696	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
395963004697	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395963004698	Catalytic site [active]
395963004699	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395963004700	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395963004701	P-loop; other site
395963004702	Magnesium ion binding site [ion binding]; other site
395963004703	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395963004704	Magnesium ion binding site [ion binding]; other site
395963004705	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
395963004706	synthetase active site [active]
395963004707	NTP binding site [chemical binding]; other site
395963004708	metal binding site [ion binding]; metal-binding site
395963004709	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
395963004710	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395963004711	active site
395963004712	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395963004713	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395963004714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004715	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395963004716	dimerization interface [polypeptide binding]; other site
395963004717	substrate binding pocket [chemical binding]; other site
395963004718	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963004719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963004720	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
395963004721	hypothetical protein; Provisional; Region: PRK05409
395963004722	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
395963004723	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963004724	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
395963004725	DNA binding residues [nucleotide binding]
395963004726	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
395963004727	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395963004728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004730	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963004731	putative effector binding pocket; other site
395963004732	dimerization interface [polypeptide binding]; other site
395963004733	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395963004734	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
395963004735	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
395963004736	RES domain; Region: RES; cl02411
395963004737	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395963004738	B12 binding site [chemical binding]; other site
395963004739	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
395963004740	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395963004741	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
395963004742	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395963004743	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395963004744	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395963004745	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
395963004746	glutamine binding [chemical binding]; other site
395963004747	catalytic triad [active]
395963004748	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
395963004749	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
395963004750	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
395963004751	active site
395963004752	anthranilate synthase component I; Provisional; Region: PRK13573
395963004753	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395963004754	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395963004755	SurA N-terminal domain; Region: SurA_N_3; cl07813
395963004756	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
395963004757	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
395963004758	substrate binding site [chemical binding]; other site
395963004759	dimer interface [polypeptide binding]; other site
395963004760	catalytic triad [active]
395963004761	CTP synthetase; Validated; Region: pyrG; PRK05380
395963004762	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
395963004763	Catalytic site [active]
395963004764	active site
395963004765	UTP binding site [chemical binding]; other site
395963004766	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
395963004767	active site
395963004768	putative oxyanion hole; other site
395963004769	catalytic triad [active]
395963004770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004772	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
395963004773	putative effector binding pocket; other site
395963004774	putative dimerization interface [polypeptide binding]; other site
395963004775	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395963004776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963004777	NAD(P) binding site [chemical binding]; other site
395963004778	active site
395963004779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963004780	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963004781	NAD(P) binding site [chemical binding]; other site
395963004782	active site
395963004783	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004785	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963004786	dimerization interface [polypeptide binding]; other site
395963004787	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
395963004788	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
395963004789	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963004790	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963004791	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395963004792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963004793	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963004794	catalytic residue [active]
395963004795	enolase; Provisional; Region: eno; PRK00077
395963004796	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
395963004797	dimer interface [polypeptide binding]; other site
395963004798	metal binding site [ion binding]; metal-binding site
395963004799	substrate binding pocket [chemical binding]; other site
395963004800	short chain dehydrogenase; Provisional; Region: PRK06180
395963004801	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963004802	NADP binding site [chemical binding]; other site
395963004803	active site
395963004804	steroid binding site; other site
395963004805	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
395963004806	short chain dehydrogenase; Provisional; Region: PRK09291
395963004807	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963004808	NADP binding site [chemical binding]; other site
395963004809	active site
395963004810	steroid binding site; other site
395963004811	Domain of unknown function (DUF336); Region: DUF336; cl01249
395963004812	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963004813	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963004814	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395963004815	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
395963004816	conserved cys residue [active]
395963004817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
395963004818	SnoaL-like domain; Region: SnoaL_2; pfam12680
395963004819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963004820	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395963004821	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395963004822	NADP binding site [chemical binding]; other site
395963004823	dimer interface [polypeptide binding]; other site
395963004824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963004825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963004826	short chain dehydrogenase; Provisional; Region: PRK06500
395963004827	classical (c) SDRs; Region: SDR_c; cd05233
395963004828	NAD(P) binding site [chemical binding]; other site
395963004829	active site
395963004830	LysR family transcriptional regulator; Provisional; Region: PRK14997
395963004831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004832	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
395963004833	putative effector binding pocket; other site
395963004834	putative dimerization interface [polypeptide binding]; other site
395963004835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
395963004836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963004837	NAD(P) binding site [chemical binding]; other site
395963004838	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963004839	active site
395963004840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963004841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963004842	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
395963004843	substrate binding pocket [chemical binding]; other site
395963004844	dimerization interface [polypeptide binding]; other site
395963004845	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
395963004846	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963004847	putative NAD(P) binding site [chemical binding]; other site
395963004848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963004849	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963004850	salt bridge; other site
395963004851	non-specific DNA binding site [nucleotide binding]; other site
395963004852	sequence-specific DNA binding site [nucleotide binding]; other site
395963004853	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
395963004854	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395963004855	SnoaL-like domain; Region: SnoaL_2; pfam12680
395963004856	Predicted transcriptional regulators [Transcription]; Region: COG1733
395963004857	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395963004858	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395963004859	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963004860	putative DNA binding site [nucleotide binding]; other site
395963004861	putative Zn2+ binding site [ion binding]; other site
395963004862	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
395963004863	Predicted transcriptional regulator [Transcription]; Region: COG2944
395963004864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963004865	non-specific DNA binding site [nucleotide binding]; other site
395963004866	salt bridge; other site
395963004867	sequence-specific DNA binding site [nucleotide binding]; other site
395963004868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963004869	AAA domain; Region: AAA_23; pfam13476
395963004870	Walker A/P-loop; other site
395963004871	ATP binding site [chemical binding]; other site
395963004872	Bacterial type III secretion protein (HrpB7); Region: HrpB7; pfam09486
395963004873	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
395963004874	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
395963004875	HSP70 interaction site [polypeptide binding]; other site
395963004876	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
395963004877	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
395963004878	putative active site [active]
395963004879	putative metal binding site [ion binding]; other site
395963004880	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395963004881	Septum formation initiator; Region: DivIC; cl17659
395963004882	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
395963004883	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395963004884	tetramer interface [polypeptide binding]; other site
395963004885	TPP-binding site [chemical binding]; other site
395963004886	heterodimer interface [polypeptide binding]; other site
395963004887	phosphorylation loop region [posttranslational modification]
395963004888	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
395963004889	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963004890	E3 interaction surface; other site
395963004891	lipoyl attachment site [posttranslational modification]; other site
395963004892	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395963004893	alpha subunit interface [polypeptide binding]; other site
395963004894	TPP binding site [chemical binding]; other site
395963004895	heterodimer interface [polypeptide binding]; other site
395963004896	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395963004897	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963004898	E3 interaction surface; other site
395963004899	lipoyl attachment site [posttranslational modification]; other site
395963004900	e3 binding domain; Region: E3_binding; pfam02817
395963004901	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
395963004902	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395963004903	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
395963004904	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
395963004905	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963004906	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395963004907	lipoyl synthase; Provisional; Region: PRK05481
395963004908	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963004909	FeS/SAM binding site; other site
395963004910	RES domain; Region: RES; pfam08808
395963004911	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
395963004912	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
395963004913	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
395963004914	putative coenzyme Q binding site [chemical binding]; other site
395963004915	major facilitator superfamily transporter; Provisional; Region: PRK05122
395963004916	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
395963004917	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395963004918	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395963004919	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
395963004920	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
395963004921	substrate binding site; other site
395963004922	dimer interface; other site
395963004923	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
395963004924	homotrimer interaction site [polypeptide binding]; other site
395963004925	zinc binding site [ion binding]; other site
395963004926	CDP-binding sites; other site
395963004927	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
395963004928	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395963004929	FMN binding site [chemical binding]; other site
395963004930	active site
395963004931	catalytic residues [active]
395963004932	substrate binding site [chemical binding]; other site
395963004933	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395963004934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963004935	dimer interface [polypeptide binding]; other site
395963004936	phosphorylation site [posttranslational modification]
395963004937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963004938	ATP binding site [chemical binding]; other site
395963004939	Mg2+ binding site [ion binding]; other site
395963004940	G-X-G motif; other site
395963004941	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
395963004942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004943	active site
395963004944	phosphorylation site [posttranslational modification]
395963004945	intermolecular recognition site; other site
395963004946	dimerization interface [polypeptide binding]; other site
395963004947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963004948	Walker A motif; other site
395963004949	ATP binding site [chemical binding]; other site
395963004950	Walker B motif; other site
395963004951	arginine finger; other site
395963004952	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
395963004953	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
395963004954	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
395963004955	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395963004956	dimerization interface [polypeptide binding]; other site
395963004957	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963004958	dimer interface [polypeptide binding]; other site
395963004959	phosphorylation site [posttranslational modification]
395963004960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963004961	ATP binding site [chemical binding]; other site
395963004962	Mg2+ binding site [ion binding]; other site
395963004963	G-X-G motif; other site
395963004964	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395963004965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963004966	active site
395963004967	phosphorylation site [posttranslational modification]
395963004968	intermolecular recognition site; other site
395963004969	dimerization interface [polypeptide binding]; other site
395963004970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963004971	Walker A motif; other site
395963004972	ATP binding site [chemical binding]; other site
395963004973	Walker B motif; other site
395963004974	arginine finger; other site
395963004975	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963004976	Chromate transporter; Region: Chromate_transp; pfam02417
395963004977	Chromate transporter; Region: Chromate_transp; pfam02417
395963004978	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395963004979	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
395963004980	homodimer interface [polypeptide binding]; other site
395963004981	substrate-cofactor binding pocket; other site
395963004982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963004983	catalytic residue [active]
395963004984	bacterial Hfq-like; Region: Hfq; cd01716
395963004985	hexamer interface [polypeptide binding]; other site
395963004986	Sm1 motif; other site
395963004987	RNA binding site [nucleotide binding]; other site
395963004988	Sm2 motif; other site
395963004989	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
395963004990	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
395963004991	HflX GTPase family; Region: HflX; cd01878
395963004992	G1 box; other site
395963004993	GTP/Mg2+ binding site [chemical binding]; other site
395963004994	Switch I region; other site
395963004995	G2 box; other site
395963004996	G3 box; other site
395963004997	Switch II region; other site
395963004998	G4 box; other site
395963004999	G5 box; other site
395963005000	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
395963005001	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
395963005002	homodimer interface [polypeptide binding]; other site
395963005003	metal binding site [ion binding]; metal-binding site
395963005004	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
395963005005	homodimer interface [polypeptide binding]; other site
395963005006	active site
395963005007	putative chemical substrate binding site [chemical binding]; other site
395963005008	metal binding site [ion binding]; metal-binding site
395963005009	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963005010	DNA-binding site [nucleotide binding]; DNA binding site
395963005011	RNA-binding motif; other site
395963005012	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963005013	DNA-binding site [nucleotide binding]; DNA binding site
395963005014	RNA-binding motif; other site
395963005015	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
395963005016	dimer interface [polypeptide binding]; other site
395963005017	TPP-binding site [chemical binding]; other site
395963005018	PYR/PP interface [polypeptide binding]; other site
395963005019	dimer interface [polypeptide binding]; other site
395963005020	TPP binding site [chemical binding]; other site
395963005021	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
395963005022	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395963005023	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963005024	putative DNA binding site [nucleotide binding]; other site
395963005025	putative Zn2+ binding site [ion binding]; other site
395963005026	AsnC family; Region: AsnC_trans_reg; pfam01037
395963005027	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
395963005028	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963005029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963005030	Walker A/P-loop; other site
395963005031	ATP binding site [chemical binding]; other site
395963005032	Q-loop/lid; other site
395963005033	ABC transporter signature motif; other site
395963005034	Walker B; other site
395963005035	D-loop; other site
395963005036	H-loop/switch region; other site
395963005037	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
395963005038	putative hydrolase; Provisional; Region: PRK02113
395963005039	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
395963005040	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
395963005041	active site
395963005042	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
395963005043	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
395963005044	active site
395963005045	HIGH motif; other site
395963005046	KMSKS motif; other site
395963005047	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
395963005048	tRNA binding surface [nucleotide binding]; other site
395963005049	anticodon binding site; other site
395963005050	DNA polymerase III subunit delta'; Validated; Region: PRK07471
395963005051	AAA ATPase domain; Region: AAA_16; pfam13191
395963005052	DNA polymerase III subunit delta'; Validated; Region: PRK08485
395963005053	thymidylate kinase; Validated; Region: tmk; PRK00698
395963005054	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
395963005055	TMP-binding site; other site
395963005056	ATP-binding site [chemical binding]; other site
395963005057	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
395963005058	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
395963005059	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395963005060	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
395963005061	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
395963005062	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395963005063	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395963005064	dimer interface [polypeptide binding]; other site
395963005065	[2Fe-2S] cluster binding site [ion binding]; other site
395963005066	H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase; Region: HMD; pfam03201
395963005067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395963005068	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
395963005069	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
395963005070	dimerization interface [polypeptide binding]; other site
395963005071	active site
395963005072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
395963005073	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395963005074	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963005075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963005076	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
395963005077	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
395963005078	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963005079	DNA-binding site [nucleotide binding]; DNA binding site
395963005080	RNA-binding motif; other site
395963005081	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963005082	DNA-binding site [nucleotide binding]; DNA binding site
395963005083	RNA-binding motif; other site
395963005084	NAD-dependent deacetylase; Provisional; Region: PRK00481
395963005085	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
395963005086	hypothetical protein; Validated; Region: PRK07586
395963005087	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395963005088	PYR/PP interface [polypeptide binding]; other site
395963005089	dimer interface [polypeptide binding]; other site
395963005090	TPP binding site [chemical binding]; other site
395963005091	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
395963005092	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
395963005093	TPP-binding site [chemical binding]; other site
395963005094	dimer interface [polypeptide binding]; other site
395963005095	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395963005096	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395963005097	oxyanion hole [active]
395963005098	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
395963005099	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
395963005100	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
395963005101	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395963005102	active site
395963005103	ribulose/triose binding site [chemical binding]; other site
395963005104	phosphate binding site [ion binding]; other site
395963005105	substrate (anthranilate) binding pocket [chemical binding]; other site
395963005106	product (indole) binding pocket [chemical binding]; other site
395963005107	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
395963005108	E-class dimer interface [polypeptide binding]; other site
395963005109	P-class dimer interface [polypeptide binding]; other site
395963005110	active site
395963005111	Cu2+ binding site [ion binding]; other site
395963005112	Zn2+ binding site [ion binding]; other site
395963005113	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
395963005114	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
395963005115	DHH family; Region: DHH; pfam01368
395963005116	DHHA1 domain; Region: DHHA1; pfam02272
395963005117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963005118	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963005119	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
395963005120	uridine kinase; Validated; Region: PRK06696
395963005121	exopolyphosphatase; Region: exo_poly_only; TIGR03706
395963005122	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395963005123	polyphosphate kinase; Provisional; Region: PRK05443
395963005124	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395963005125	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395963005126	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395963005127	putative domain interface [polypeptide binding]; other site
395963005128	putative active site [active]
395963005129	catalytic site [active]
395963005130	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395963005131	putative domain interface [polypeptide binding]; other site
395963005132	putative active site [active]
395963005133	catalytic site [active]
395963005134	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395963005135	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
395963005136	AsnC family; Region: AsnC_trans_reg; pfam01037
395963005137	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
395963005138	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
395963005139	hexamer interface [polypeptide binding]; other site
395963005140	ligand binding site [chemical binding]; other site
395963005141	putative active site [active]
395963005142	NAD(P) binding site [chemical binding]; other site
395963005143	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
395963005144	putative FMN binding site [chemical binding]; other site
395963005145	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
395963005146	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395963005147	hypothetical protein; Validated; Region: PRK00041
395963005148	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
395963005149	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
395963005150	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395963005151	trimerization site [polypeptide binding]; other site
395963005152	active site
395963005153	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
395963005154	GTP cyclohydrolase I; Provisional; Region: PLN03044
395963005155	active site
395963005156	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
395963005157	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
395963005158	FOG: CBS domain [General function prediction only]; Region: COG0517
395963005159	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
395963005160	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
395963005161	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
395963005162	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395963005163	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395963005164	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
395963005165	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
395963005166	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
395963005167	Walker A motif; other site
395963005168	ATP binding site [chemical binding]; other site
395963005169	Walker B motif; other site
395963005170	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
395963005171	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395963005172	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
395963005173	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
395963005174	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
395963005175	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
395963005176	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
395963005177	Isochorismatase family; Region: Isochorismatase; pfam00857
395963005178	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
395963005179	catalytic triad [active]
395963005180	metal binding site [ion binding]; metal-binding site
395963005181	conserved cis-peptide bond; other site
395963005182	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
395963005183	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
395963005184	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963005185	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
395963005186	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
395963005187	putative active site [active]
395963005188	putative PHP Thumb interface [polypeptide binding]; other site
395963005189	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395963005190	generic binding surface II; other site
395963005191	generic binding surface I; other site
395963005192	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395963005193	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395963005194	Walker A/P-loop; other site
395963005195	ATP binding site [chemical binding]; other site
395963005196	Q-loop/lid; other site
395963005197	ABC transporter signature motif; other site
395963005198	Walker B; other site
395963005199	D-loop; other site
395963005200	H-loop/switch region; other site
395963005201	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395963005202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963005203	dimer interface [polypeptide binding]; other site
395963005204	conserved gate region; other site
395963005205	putative PBP binding loops; other site
395963005206	ABC-ATPase subunit interface; other site
395963005207	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
395963005208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395963005209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963005210	dimer interface [polypeptide binding]; other site
395963005211	ABC-ATPase subunit interface; other site
395963005212	putative PBP binding loops; other site
395963005213	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
395963005214	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963005215	substrate binding pocket [chemical binding]; other site
395963005216	membrane-bound complex binding site; other site
395963005217	hinge residues; other site
395963005218	haemagglutination activity domain; Region: Haemagg_act; smart00912
395963005219	cystathionine beta-lyase; Provisional; Region: PRK05967
395963005220	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963005221	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963005222	catalytic residue [active]
395963005223	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395963005224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395963005225	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
395963005226	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
395963005227	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
395963005228	MoFe protein beta/alpha subunit interactions; other site
395963005229	Beta subunit P cluster binding residues; other site
395963005230	MoFe protein beta subunit/Fe protein contacts; other site
395963005231	MoFe protein dimer/ dimer interactions; other site
395963005232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395963005233	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
395963005234	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
395963005235	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
395963005236	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963005237	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963005238	active site
395963005239	nucleophile elbow; other site
395963005240	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
395963005241	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
395963005242	active site
395963005243	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
395963005244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963005245	dimer interface [polypeptide binding]; other site
395963005246	conserved gate region; other site
395963005247	putative PBP binding loops; other site
395963005248	ABC-ATPase subunit interface; other site
395963005249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963005250	putative PBP binding loops; other site
395963005251	dimer interface [polypeptide binding]; other site
395963005252	ABC-ATPase subunit interface; other site
395963005253	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395963005254	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963005255	Walker A/P-loop; other site
395963005256	ATP binding site [chemical binding]; other site
395963005257	Q-loop/lid; other site
395963005258	ABC transporter signature motif; other site
395963005259	Walker B; other site
395963005260	D-loop; other site
395963005261	H-loop/switch region; other site
395963005262	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
395963005263	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395963005264	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395963005265	active site
395963005266	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
395963005267	MgtE intracellular N domain; Region: MgtE_N; smart00924
395963005268	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
395963005269	Divalent cation transporter; Region: MgtE; cl00786
395963005270	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395963005271	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
395963005272	NodB motif; other site
395963005273	active site
395963005274	catalytic site [active]
395963005275	metal binding site [ion binding]; metal-binding site
395963005276	lipoate-protein ligase B; Provisional; Region: PRK14341
395963005277	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395963005278	MarR family; Region: MarR_2; pfam12802
395963005279	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963005280	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395963005281	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395963005282	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963005283	hypothetical protein; Provisional; Region: PRK05170
395963005284	Transglycosylase; Region: Transgly; pfam00912
395963005285	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395963005286	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395963005287	hypothetical protein; Provisional; Region: PRK13687
395963005288	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395963005289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963005290	Coenzyme A binding pocket [chemical binding]; other site
395963005291	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
395963005292	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
395963005293	hinge; other site
395963005294	active site
395963005295	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395963005296	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395963005297	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
395963005298	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395963005299	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395963005300	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
395963005301	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
395963005302	Predicted integral membrane protein [Function unknown]; Region: COG5436
395963005303	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
395963005304	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395963005305	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395963005306	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963005307	PAS fold; Region: PAS; pfam00989
395963005308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963005309	putative active site [active]
395963005310	heme pocket [chemical binding]; other site
395963005311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963005312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963005313	dimer interface [polypeptide binding]; other site
395963005314	phosphorylation site [posttranslational modification]
395963005315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963005316	ATP binding site [chemical binding]; other site
395963005317	Mg2+ binding site [ion binding]; other site
395963005318	G-X-G motif; other site
395963005319	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
395963005320	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
395963005321	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395963005322	SelR domain; Region: SelR; pfam01641
395963005323	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
395963005324	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963005325	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395963005326	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
395963005327	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395963005328	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
395963005329	putative active site [active]
395963005330	YdjC motif; other site
395963005331	Mg binding site [ion binding]; other site
395963005332	putative homodimer interface [polypeptide binding]; other site
395963005333	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963005334	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963005335	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963005336	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395963005337	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395963005338	Ligand binding site; other site
395963005339	Putative Catalytic site; other site
395963005340	DXD motif; other site
395963005341	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
395963005342	MviN-like protein; Region: MVIN; pfam03023
395963005343	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395963005344	active site
395963005345	NTP binding site [chemical binding]; other site
395963005346	metal binding triad [ion binding]; metal-binding site
395963005347	antibiotic binding site [chemical binding]; other site
395963005348	Uncharacterized conserved protein [Function unknown]; Region: COG2361
395963005349	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
395963005350	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
395963005351	Potassium binding sites [ion binding]; other site
395963005352	Cesium cation binding sites [ion binding]; other site
395963005353	hypothetical protein; Validated; Region: PRK09104
395963005354	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
395963005355	metal binding site [ion binding]; metal-binding site
395963005356	putative dimer interface [polypeptide binding]; other site
395963005357	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
395963005358	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
395963005359	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
395963005360	putative substrate binding pocket [chemical binding]; other site
395963005361	AC domain interface; other site
395963005362	catalytic triad [active]
395963005363	AB domain interface; other site
395963005364	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395963005365	putative hydrophobic ligand binding site [chemical binding]; other site
395963005366	protein interface [polypeptide binding]; other site
395963005367	gate; other site
395963005368	aspartate aminotransferase; Provisional; Region: PRK05764
395963005369	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963005370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963005371	homodimer interface [polypeptide binding]; other site
395963005372	catalytic residue [active]
395963005373	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
395963005374	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
395963005375	catalytic residues [active]
395963005376	amino acid transporter; Region: 2A0306; TIGR00909
395963005377	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
395963005378	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
395963005379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963005380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
395963005381	Protein of unknown function, DUF482; Region: DUF482; pfam04339
395963005382	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
395963005383	HIT family signature motif; other site
395963005384	catalytic residue [active]
395963005385	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
395963005386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963005387	Walker A motif; other site
395963005388	ATP binding site [chemical binding]; other site
395963005389	Walker B motif; other site
395963005390	arginine finger; other site
395963005391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963005392	Walker A motif; other site
395963005393	ATP binding site [chemical binding]; other site
395963005394	Walker B motif; other site
395963005395	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395963005396	Uncharacterized conserved protein [Function unknown]; Region: COG2127
395963005397	Phasin protein; Region: Phasin_2; pfam09361
395963005398	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395963005399	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395963005400	Sporulation related domain; Region: SPOR; pfam05036
395963005401	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395963005402	HSP70 interaction site [polypeptide binding]; other site
395963005403	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
395963005404	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963005405	putative C-terminal domain interface [polypeptide binding]; other site
395963005406	putative GSH binding site (G-site) [chemical binding]; other site
395963005407	putative dimer interface [polypeptide binding]; other site
395963005408	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
395963005409	putative N-terminal domain interface [polypeptide binding]; other site
395963005410	putative dimer interface [polypeptide binding]; other site
395963005411	putative substrate binding pocket (H-site) [chemical binding]; other site
395963005412	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395963005413	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395963005414	putative active site [active]
395963005415	Domain of unknown function (DUF329); Region: DUF329; cl01144
395963005416	Maf-like protein; Region: Maf; pfam02545
395963005417	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
395963005418	active site
395963005419	dimer interface [polypeptide binding]; other site
395963005420	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
395963005421	rRNA binding site [nucleotide binding]; other site
395963005422	predicted 30S ribosome binding site; other site
395963005423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963005424	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
395963005425	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
395963005426	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395963005427	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
395963005428	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
395963005429	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963005430	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963005431	salt bridge; other site
395963005432	non-specific DNA binding site [nucleotide binding]; other site
395963005433	sequence-specific DNA binding site [nucleotide binding]; other site
395963005434	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395963005435	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395963005436	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395963005437	HSP70 interaction site [polypeptide binding]; other site
395963005438	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
395963005439	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395963005440	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395963005441	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395963005442	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395963005443	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395963005444	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395963005445	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395963005446	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963005447	OsmC-like protein; Region: OsmC; cl00767
395963005448	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
395963005449	putative nucleotide binding site [chemical binding]; other site
395963005450	putative substrate binding site [chemical binding]; other site
395963005451	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
395963005452	nucleotide binding site [chemical binding]; other site
395963005453	substrate binding site [chemical binding]; other site
395963005454	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
395963005455	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963005456	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
395963005457	B1 nucleotide binding pocket [chemical binding]; other site
395963005458	B2 nucleotide binding pocket [chemical binding]; other site
395963005459	CAS motifs; other site
395963005460	active site
395963005461	HdeA/HdeB family; Region: HdeA; cl05752
395963005462	HdeA/HdeB family; Region: HdeA; pfam06411
395963005463	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
395963005464	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
395963005465	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
395963005466	Switch I; other site
395963005467	Switch II; other site
395963005468	septum formation inhibitor; Reviewed; Region: minC; PRK05177
395963005469	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
395963005470	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
395963005471	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395963005472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963005473	putative substrate translocation pore; other site
395963005474	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
395963005475	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
395963005476	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
395963005477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963005478	active site
395963005479	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395963005480	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
395963005481	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
395963005482	GIY-YIG motif/motif A; other site
395963005483	active site
395963005484	catalytic site [active]
395963005485	putative DNA binding site [nucleotide binding]; other site
395963005486	metal binding site [ion binding]; metal-binding site
395963005487	UvrB/uvrC motif; Region: UVR; pfam02151
395963005488	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
395963005489	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
395963005490	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
395963005491	MoaE interaction surface [polypeptide binding]; other site
395963005492	MoeB interaction surface [polypeptide binding]; other site
395963005493	thiocarboxylated glycine; other site
395963005494	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
395963005495	MoaE homodimer interface [polypeptide binding]; other site
395963005496	MoaD interaction [polypeptide binding]; other site
395963005497	active site residues [active]
395963005498	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
395963005499	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395963005500	Surface antigen; Region: Bac_surface_Ag; pfam01103
395963005501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
395963005502	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395963005503	Family of unknown function (DUF490); Region: DUF490; pfam04357
395963005504	topology modulation protein; Reviewed; Region: PRK08118
395963005505	AAA domain; Region: AAA_17; pfam13207
395963005506	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
395963005507	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963005508	DNA-binding site [nucleotide binding]; DNA binding site
395963005509	FCD domain; Region: FCD; pfam07729
395963005510	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
395963005511	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
395963005512	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
395963005513	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
395963005514	MOFRL family; Region: MOFRL; pfam05161
395963005515	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
395963005516	active site
395963005517	catalytic triad [active]
395963005518	oxyanion hole [active]
395963005519	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
395963005520	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395963005521	HIGH motif; other site
395963005522	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395963005523	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395963005524	active site
395963005525	KMSKS motif; other site
395963005526	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
395963005527	tRNA binding surface [nucleotide binding]; other site
395963005528	anticodon binding site; other site
395963005529	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
395963005530	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
395963005531	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
395963005532	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395963005533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963005534	S-adenosylmethionine binding site [chemical binding]; other site
395963005535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963005536	Coenzyme A binding pocket [chemical binding]; other site
395963005537	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395963005538	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
395963005539	folate binding site [chemical binding]; other site
395963005540	NADP+ binding site [chemical binding]; other site
395963005541	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
395963005542	HflK protein; Region: hflK; TIGR01933
395963005543	HflC protein; Region: hflC; TIGR01932
395963005544	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
395963005545	hypothetical protein; Provisional; Region: PRK10316
395963005546	YfdX protein; Region: YfdX; pfam10938
395963005547	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395963005548	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963005549	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963005550	protein binding site [polypeptide binding]; other site
395963005551	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963005552	protein binding site [polypeptide binding]; other site
395963005553	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963005554	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963005555	active site
395963005556	nucleophile elbow; other site
395963005557	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963005558	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963005559	catalytic loop [active]
395963005560	iron binding site [ion binding]; other site
395963005561	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395963005562	cyclase homology domain; Region: CHD; cd07302
395963005563	nucleotidyl binding site; other site
395963005564	metal binding site [ion binding]; metal-binding site
395963005565	dimer interface [polypeptide binding]; other site
395963005566	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395963005567	oligomerisation interface [polypeptide binding]; other site
395963005568	mobile loop; other site
395963005569	roof hairpin; other site
395963005570	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395963005571	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395963005572	ring oligomerisation interface [polypeptide binding]; other site
395963005573	ATP/Mg binding site [chemical binding]; other site
395963005574	stacking interactions; other site
395963005575	hinge regions; other site
395963005576	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395963005577	IHF - DNA interface [nucleotide binding]; other site
395963005578	IHF dimer interface [polypeptide binding]; other site
395963005579	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395963005580	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395963005581	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
395963005582	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395963005583	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395963005584	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395963005585	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395963005586	Walker A/P-loop; other site
395963005587	ATP binding site [chemical binding]; other site
395963005588	Q-loop/lid; other site
395963005589	ABC transporter signature motif; other site
395963005590	Walker B; other site
395963005591	D-loop; other site
395963005592	H-loop/switch region; other site
395963005593	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395963005594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963005595	Walker A/P-loop; other site
395963005596	ATP binding site [chemical binding]; other site
395963005597	Q-loop/lid; other site
395963005598	ABC transporter signature motif; other site
395963005599	Walker B; other site
395963005600	D-loop; other site
395963005601	H-loop/switch region; other site
395963005602	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395963005603	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395963005604	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
395963005605	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395963005606	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963005607	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963005608	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
395963005609	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963005610	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963005611	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395963005612	enoyl-CoA hydratase; Provisional; Region: PRK06688
395963005613	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963005614	substrate binding site [chemical binding]; other site
395963005615	oxyanion hole (OAH) forming residues; other site
395963005616	trimer interface [polypeptide binding]; other site
395963005617	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
395963005618	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395963005619	FMN binding site [chemical binding]; other site
395963005620	substrate binding site [chemical binding]; other site
395963005621	putative catalytic residue [active]
395963005622	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395963005623	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963005624	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
395963005625	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
395963005626	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395963005627	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395963005628	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395963005629	Ligand binding site [chemical binding]; other site
395963005630	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395963005631	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395963005632	active site
395963005633	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
395963005634	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
395963005635	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395963005636	active site
395963005637	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
395963005638	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
395963005639	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395963005640	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395963005641	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395963005642	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963005643	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395963005644	substrate binding site [chemical binding]; other site
395963005645	oxyanion hole (OAH) forming residues; other site
395963005646	trimer interface [polypeptide binding]; other site
395963005647	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395963005648	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
395963005649	dimer interface [polypeptide binding]; other site
395963005650	active site
395963005651	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
395963005652	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
395963005653	acyl-activating enzyme (AAE) consensus motif; other site
395963005654	putative AMP binding site [chemical binding]; other site
395963005655	putative active site [active]
395963005656	putative CoA binding site [chemical binding]; other site
395963005657	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
395963005658	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395963005659	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963005660	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963005661	short chain dehydrogenase; Provisional; Region: PRK06172
395963005662	classical (c) SDRs; Region: SDR_c; cd05233
395963005663	NAD(P) binding site [chemical binding]; other site
395963005664	active site
395963005665	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395963005666	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395963005667	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963005668	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395963005669	iron-sulfur cluster [ion binding]; other site
395963005670	[2Fe-2S] cluster binding site [ion binding]; other site
395963005671	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963005672	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963005673	active site
395963005674	catalytic tetrad [active]
395963005675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
395963005676	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
395963005677	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963005678	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395963005679	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
395963005680	putative NAD(P) binding site [chemical binding]; other site
395963005681	putative substrate binding site [chemical binding]; other site
395963005682	catalytic Zn binding site [ion binding]; other site
395963005683	structural Zn binding site [ion binding]; other site
395963005684	dimer interface [polypeptide binding]; other site
395963005685	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963005686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963005687	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395963005688	putative effector binding pocket; other site
395963005689	putative dimerization interface [polypeptide binding]; other site
395963005690	TIR domain; Region: TIR_2; cl17458
395963005691	AAA ATPase domain; Region: AAA_16; pfam13191
395963005692	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
395963005693	dimerization interface [polypeptide binding]; other site
395963005694	putative active cleft [active]
395963005695	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
395963005696	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
395963005697	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
395963005698	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395963005699	dimer interface [polypeptide binding]; other site
395963005700	active site
395963005701	motif 2; other site
395963005702	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395963005703	active site
395963005704	motif 3; other site
395963005705	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
395963005706	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
395963005707	dimer interface [polypeptide binding]; other site
395963005708	motif 1; other site
395963005709	active site
395963005710	motif 2; other site
395963005711	motif 3; other site
395963005712	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
395963005713	anticodon binding site; other site
395963005714	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
395963005715	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
395963005716	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395963005717	ATP binding site [chemical binding]; other site
395963005718	Mg++ binding site [ion binding]; other site
395963005719	motif III; other site
395963005720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963005721	nucleotide binding region [chemical binding]; other site
395963005722	ATP-binding site [chemical binding]; other site
395963005723	Flagellin N-methylase; Region: FliB; pfam03692
395963005724	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
395963005725	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
395963005726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963005727	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963005728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
395963005729	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
395963005730	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963005731	FeS/SAM binding site; other site
395963005732	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
395963005733	Domain of unknown function DUF59; Region: DUF59; pfam01883
395963005734	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
395963005735	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
395963005736	Walker A motif; other site
395963005737	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
395963005738	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963005739	substrate binding pocket [chemical binding]; other site
395963005740	membrane-bound complex binding site; other site
395963005741	hinge residues; other site
395963005742	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395963005743	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395963005744	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
395963005745	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963005746	substrate binding site [chemical binding]; other site
395963005747	oxyanion hole (OAH) forming residues; other site
395963005748	trimer interface [polypeptide binding]; other site
395963005749	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
395963005750	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
395963005751	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395963005752	homotrimer interaction site [polypeptide binding]; other site
395963005753	putative active site [active]
395963005754	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
395963005755	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395963005756	active site
395963005757	catalytic site [active]
395963005758	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
395963005759	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
395963005760	dimer interface [polypeptide binding]; other site
395963005761	PYR/PP interface [polypeptide binding]; other site
395963005762	TPP binding site [chemical binding]; other site
395963005763	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395963005764	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
395963005765	TPP-binding site [chemical binding]; other site
395963005766	dimer interface [polypeptide binding]; other site
395963005767	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395963005768	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395963005769	Walker A/P-loop; other site
395963005770	ATP binding site [chemical binding]; other site
395963005771	Q-loop/lid; other site
395963005772	ABC transporter signature motif; other site
395963005773	Walker B; other site
395963005774	D-loop; other site
395963005775	H-loop/switch region; other site
395963005776	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
395963005777	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395963005778	FtsX-like permease family; Region: FtsX; pfam02687
395963005779	prolyl-tRNA synthetase; Provisional; Region: PRK12325
395963005780	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
395963005781	dimer interface [polypeptide binding]; other site
395963005782	motif 1; other site
395963005783	active site
395963005784	motif 2; other site
395963005785	motif 3; other site
395963005786	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
395963005787	anticodon binding site; other site
395963005788	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
395963005789	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395963005790	dimerization interface [polypeptide binding]; other site
395963005791	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395963005792	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395963005793	dimer interface [polypeptide binding]; other site
395963005794	putative CheW interface [polypeptide binding]; other site
395963005795	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395963005796	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395963005797	active site
395963005798	TDP-binding site; other site
395963005799	acceptor substrate-binding pocket; other site
395963005800	homodimer interface [polypeptide binding]; other site
395963005801	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
395963005802	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
395963005803	glutaminase active site [active]
395963005804	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395963005805	dimer interface [polypeptide binding]; other site
395963005806	active site
395963005807	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395963005808	dimer interface [polypeptide binding]; other site
395963005809	active site
395963005810	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
395963005811	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
395963005812	Substrate binding site; other site
395963005813	Mg++ binding site; other site
395963005814	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
395963005815	active site
395963005816	substrate binding site [chemical binding]; other site
395963005817	CoA binding site [chemical binding]; other site
395963005818	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
395963005819	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395963005820	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
395963005821	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
395963005822	Ligand binding site; other site
395963005823	DXD motif; other site
395963005824	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
395963005825	Cytochrome P450; Region: p450; cl12078
395963005826	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395963005827	Ion channel; Region: Ion_trans_2; pfam07885
395963005828	pyruvate phosphate dikinase; Provisional; Region: PRK09279
395963005829	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395963005830	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395963005831	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395963005832	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
395963005833	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
395963005834	TPP-binding site; other site
395963005835	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395963005836	PYR/PP interface [polypeptide binding]; other site
395963005837	dimer interface [polypeptide binding]; other site
395963005838	TPP binding site [chemical binding]; other site
395963005839	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395963005840	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
395963005841	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963005842	RNA binding surface [nucleotide binding]; other site
395963005843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963005844	S-adenosylmethionine binding site [chemical binding]; other site
395963005845	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
395963005846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963005847	S-adenosylmethionine binding site [chemical binding]; other site
395963005848	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395963005849	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
395963005850	putative FMN binding site [chemical binding]; other site
395963005851	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395963005852	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
395963005853	NAD(P) binding site [chemical binding]; other site
395963005854	catalytic residues [active]
395963005855	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963005856	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395963005857	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
395963005858	N-terminal domain interface [polypeptide binding]; other site
395963005859	short chain dehydrogenase; Provisional; Region: PRK06482
395963005860	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963005861	NADP binding site [chemical binding]; other site
395963005862	active site
395963005863	steroid binding site; other site
395963005864	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963005865	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395963005866	MarR family; Region: MarR_2; cl17246
395963005867	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395963005868	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395963005869	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
395963005870	putative NADP binding site [chemical binding]; other site
395963005871	Cupin; Region: Cupin_6; pfam12852
395963005872	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395963005873	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963005874	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963005875	short chain dehydrogenase; Provisional; Region: PRK06180
395963005876	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395963005877	NADP binding site [chemical binding]; other site
395963005878	active site
395963005879	steroid binding site; other site
395963005880	Uncharacterized conserved protein [Function unknown]; Region: COG5361
395963005881	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
395963005882	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
395963005883	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963005884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963005885	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963005886	putative effector binding pocket; other site
395963005887	dimerization interface [polypeptide binding]; other site
395963005888	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395963005889	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395963005890	FMN binding site [chemical binding]; other site
395963005891	active site
395963005892	substrate binding site [chemical binding]; other site
395963005893	catalytic residue [active]
395963005894	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
395963005895	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395963005896	putative NAD(P) binding site [chemical binding]; other site
395963005897	YHS domain; Region: YHS; pfam04945
395963005898	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
395963005899	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963005900	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
395963005901	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
395963005902	Phosphoesterase family; Region: Phosphoesterase; pfam04185
395963005903	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963005904	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963005905	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395963005906	putative catalytic residues [active]
395963005907	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
395963005908	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395963005909	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395963005910	catalytic triad [active]
395963005911	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395963005912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963005913	S-adenosylmethionine binding site [chemical binding]; other site
395963005914	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395963005915	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963005916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963005917	active site
395963005918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963005919	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963005920	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963005921	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395963005922	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
395963005923	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
395963005924	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
395963005925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963005926	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963005927	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963005928	active site
395963005929	non-prolyl cis peptide bond; other site
395963005930	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
395963005931	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963005932	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963005933	active site
395963005934	non-prolyl cis peptide bond; other site
395963005935	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
395963005936	dimer interface [polypeptide binding]; other site
395963005937	FMN binding site [chemical binding]; other site
395963005938	NADPH bind site [chemical binding]; other site
395963005939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395963005940	active site
395963005941	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395963005942	active site
395963005943	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
395963005944	dimer interface [polypeptide binding]; other site
395963005945	non-prolyl cis peptide bond; other site
395963005946	insertion regions; other site
395963005947	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
395963005948	polypeptide substrate binding site [polypeptide binding]; other site
395963005949	active site
395963005950	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963005951	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963005952	nucleophile elbow; other site
395963005953	Patatin phospholipase; Region: DUF3734; pfam12536
395963005954	putative cation:proton antiport protein; Provisional; Region: PRK10669
395963005955	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
395963005956	TrkA-N domain; Region: TrkA_N; pfam02254
395963005957	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963005958	Ligand Binding Site [chemical binding]; other site
395963005959	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963005960	Ligand Binding Site [chemical binding]; other site
395963005961	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395963005962	Sel1-like repeats; Region: SEL1; smart00671
395963005963	Sel1-like repeats; Region: SEL1; smart00671
395963005964	pyruvate kinase; Provisional; Region: PRK06247
395963005965	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395963005966	domain interfaces; other site
395963005967	active site
395963005968	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395963005969	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395963005970	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395963005971	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395963005972	NAD binding site [chemical binding]; other site
395963005973	homodimer interface [polypeptide binding]; other site
395963005974	active site
395963005975	substrate binding site [chemical binding]; other site
395963005976	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
395963005977	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
395963005978	Tetramer interface [polypeptide binding]; other site
395963005979	active site
395963005980	FMN-binding site [chemical binding]; other site
395963005981	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
395963005982	SmpB-tmRNA interface; other site
395963005983	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395963005984	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
395963005985	dimer interface [polypeptide binding]; other site
395963005986	active site
395963005987	catalytic residue [active]
395963005988	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395963005989	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963005990	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963005991	catalytic residue [active]
395963005992	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963005993	Porin subfamily; Region: Porin_2; pfam02530
395963005994	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395963005995	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
395963005996	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
395963005997	GatB domain; Region: GatB_Yqey; smart00845
395963005998	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
395963005999	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
395963006000	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
395963006001	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
395963006002	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
395963006003	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
395963006004	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
395963006005	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
395963006006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963006007	PAS fold; Region: PAS_3; pfam08447
395963006008	putative active site [active]
395963006009	heme pocket [chemical binding]; other site
395963006010	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006011	dimer interface [polypeptide binding]; other site
395963006012	phosphorylation site [posttranslational modification]
395963006013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006014	ATP binding site [chemical binding]; other site
395963006015	Mg2+ binding site [ion binding]; other site
395963006016	G-X-G motif; other site
395963006017	Response regulator receiver domain; Region: Response_reg; pfam00072
395963006018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006019	active site
395963006020	phosphorylation site [posttranslational modification]
395963006021	intermolecular recognition site; other site
395963006022	dimerization interface [polypeptide binding]; other site
395963006023	Response regulator receiver domain; Region: Response_reg; pfam00072
395963006024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006025	active site
395963006026	phosphorylation site [posttranslational modification]
395963006027	intermolecular recognition site; other site
395963006028	dimerization interface [polypeptide binding]; other site
395963006029	Response regulator receiver domain; Region: Response_reg; pfam00072
395963006030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006031	active site
395963006032	phosphorylation site [posttranslational modification]
395963006033	intermolecular recognition site; other site
395963006034	dimerization interface [polypeptide binding]; other site
395963006035	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963006036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006037	dimer interface [polypeptide binding]; other site
395963006038	phosphorylation site [posttranslational modification]
395963006039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006040	ATP binding site [chemical binding]; other site
395963006041	Mg2+ binding site [ion binding]; other site
395963006042	G-X-G motif; other site
395963006043	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
395963006044	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
395963006045	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963006046	dimerization interface [polypeptide binding]; other site
395963006047	putative DNA binding site [nucleotide binding]; other site
395963006048	putative Zn2+ binding site [ion binding]; other site
395963006049	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
395963006050	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
395963006051	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
395963006052	active site clefts [active]
395963006053	zinc binding site [ion binding]; other site
395963006054	dimer interface [polypeptide binding]; other site
395963006055	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963006056	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395963006057	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
395963006058	NADP binding site [chemical binding]; other site
395963006059	Phosphopantetheine attachment site; Region: PP-binding; cl09936
395963006060	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
395963006061	acyl-CoA synthetase; Validated; Region: PRK09192
395963006062	acyl-activating enzyme (AAE) consensus motif; other site
395963006063	active site
395963006064	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395963006065	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395963006066	putative acyl-acceptor binding pocket; other site
395963006067	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
395963006068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006069	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963006070	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
395963006071	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395963006072	malate synthase G; Provisional; Region: PRK02999
395963006073	active site
395963006074	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
395963006075	FAD binding domain; Region: FAD_binding_4; pfam01565
395963006076	FAD binding domain; Region: FAD_binding_4; pfam01565
395963006077	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
395963006078	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
395963006079	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395963006080	Cysteine-rich domain; Region: CCG; pfam02754
395963006081	Cysteine-rich domain; Region: CCG; pfam02754
395963006082	Protein of unknown function (DUF535); Region: DUF535; cl01128
395963006083	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395963006084	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
395963006085	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
395963006086	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963006087	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963006088	catalytic loop [active]
395963006089	iron binding site [ion binding]; other site
395963006090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
395963006091	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963006092	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395963006093	nucleoside/Zn binding site; other site
395963006094	dimer interface [polypeptide binding]; other site
395963006095	catalytic motif [active]
395963006096	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963006097	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
395963006098	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
395963006099	Walker A/P-loop; other site
395963006100	ATP binding site [chemical binding]; other site
395963006101	Q-loop/lid; other site
395963006102	ABC transporter signature motif; other site
395963006103	Walker B; other site
395963006104	D-loop; other site
395963006105	H-loop/switch region; other site
395963006106	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
395963006107	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395963006108	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
395963006109	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
395963006110	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
395963006111	active site
395963006112	catalytic residues [active]
395963006113	metal binding site [ion binding]; metal-binding site
395963006114	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395963006115	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395963006116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963006117	Coenzyme A binding pocket [chemical binding]; other site
395963006118	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
395963006119	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395963006120	active site
395963006121	HIGH motif; other site
395963006122	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395963006123	KMSKS motif; other site
395963006124	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
395963006125	tRNA binding surface [nucleotide binding]; other site
395963006126	anticodon binding site; other site
395963006127	YaaC-like Protein; Region: YaaC; pfam14175
395963006128	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
395963006129	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
395963006130	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
395963006131	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395963006132	MAPEG family; Region: MAPEG; cl09190
395963006133	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
395963006134	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395963006135	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
395963006136	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
395963006137	active site
395963006138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006139	putative transporter; Provisional; Region: PRK10504
395963006140	putative substrate translocation pore; other site
395963006141	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963006142	Ligand Binding Site [chemical binding]; other site
395963006143	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
395963006144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963006145	S-adenosylmethionine binding site [chemical binding]; other site
395963006146	exopolyphosphatase; Region: exo_poly_only; TIGR03706
395963006147	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395963006148	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
395963006149	ligand binding site [chemical binding]; other site
395963006150	active site
395963006151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963006152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006153	dimer interface [polypeptide binding]; other site
395963006154	phosphorylation site [posttranslational modification]
395963006155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006156	ATP binding site [chemical binding]; other site
395963006157	Mg2+ binding site [ion binding]; other site
395963006158	G-X-G motif; other site
395963006159	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
395963006160	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
395963006161	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
395963006162	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395963006163	Uncharacterized conserved protein [Function unknown]; Region: COG2353
395963006164	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395963006165	YceI-like domain; Region: YceI; pfam04264
395963006166	Pirin-related protein [General function prediction only]; Region: COG1741
395963006167	Pirin; Region: Pirin; pfam02678
395963006168	acetoacetate decarboxylase; Provisional; Region: PRK02265
395963006169	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
395963006170	peroxiredoxin; Provisional; Region: PRK13189
395963006171	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
395963006172	dimer interface [polypeptide binding]; other site
395963006173	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395963006174	catalytic triad [active]
395963006175	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
395963006176	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963006177	dimerization interface [polypeptide binding]; other site
395963006178	putative DNA binding site [nucleotide binding]; other site
395963006179	putative Zn2+ binding site [ion binding]; other site
395963006180	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395963006181	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
395963006182	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395963006183	CAP-like domain; other site
395963006184	active site
395963006185	primary dimer interface [polypeptide binding]; other site
395963006186	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
395963006187	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
395963006188	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963006189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963006190	TPR motif; other site
395963006191	binding surface
395963006192	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963006193	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963006194	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963006195	TPR motif; other site
395963006196	binding surface
395963006197	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395963006198	Sulfatase; Region: Sulfatase; pfam00884
395963006199	elongation factor Tu; Reviewed; Region: PRK00049
395963006200	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395963006201	G1 box; other site
395963006202	GEF interaction site [polypeptide binding]; other site
395963006203	GTP/Mg2+ binding site [chemical binding]; other site
395963006204	Switch I region; other site
395963006205	G2 box; other site
395963006206	G3 box; other site
395963006207	Switch II region; other site
395963006208	G4 box; other site
395963006209	G5 box; other site
395963006210	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395963006211	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395963006212	Antibiotic Binding Site [chemical binding]; other site
395963006213	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
395963006214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
395963006215	NADH dehydrogenase; Validated; Region: PRK08183
395963006216	LrgA family; Region: LrgA; pfam03788
395963006217	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
395963006218	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
395963006219	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
395963006220	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395963006221	Transcriptional regulator; Region: Transcrip_reg; cl00361
395963006222	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
395963006223	active site
395963006224	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395963006225	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395963006226	TSCPD domain; Region: TSCPD; pfam12637
395963006227	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
395963006228	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395963006229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963006230	PAS fold; Region: PAS_3; pfam08447
395963006231	putative active site [active]
395963006232	heme pocket [chemical binding]; other site
395963006233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006234	dimer interface [polypeptide binding]; other site
395963006235	phosphorylation site [posttranslational modification]
395963006236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006237	ATP binding site [chemical binding]; other site
395963006238	Mg2+ binding site [ion binding]; other site
395963006239	G-X-G motif; other site
395963006240	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963006241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006242	active site
395963006243	phosphorylation site [posttranslational modification]
395963006244	intermolecular recognition site; other site
395963006245	dimerization interface [polypeptide binding]; other site
395963006246	Response regulator receiver domain; Region: Response_reg; pfam00072
395963006247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006248	active site
395963006249	phosphorylation site [posttranslational modification]
395963006250	intermolecular recognition site; other site
395963006251	dimerization interface [polypeptide binding]; other site
395963006252	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395963006253	putative binding surface; other site
395963006254	active site
395963006255	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
395963006256	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963006257	putative C-terminal domain interface [polypeptide binding]; other site
395963006258	putative GSH binding site (G-site) [chemical binding]; other site
395963006259	putative dimer interface [polypeptide binding]; other site
395963006260	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
395963006261	putative N-terminal domain interface [polypeptide binding]; other site
395963006262	putative dimer interface [polypeptide binding]; other site
395963006263	putative substrate binding pocket (H-site) [chemical binding]; other site
395963006264	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
395963006265	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395963006266	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963006267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006268	active site
395963006269	phosphorylation site [posttranslational modification]
395963006270	intermolecular recognition site; other site
395963006271	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
395963006272	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
395963006273	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
395963006274	NAD(P) binding site [chemical binding]; other site
395963006275	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
395963006276	glutathione s-transferase; Provisional; Region: PTZ00057
395963006277	GSH binding site (G-site) [chemical binding]; other site
395963006278	C-terminal domain interface [polypeptide binding]; other site
395963006279	dimer interface [polypeptide binding]; other site
395963006280	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
395963006281	dimer interface [polypeptide binding]; other site
395963006282	N-terminal domain interface [polypeptide binding]; other site
395963006283	substrate binding pocket (H-site) [chemical binding]; other site
395963006284	Amidinotransferase; Region: Amidinotransf; cl12043
395963006285	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
395963006286	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
395963006287	Walker A motif; other site
395963006288	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395963006289	NMT1-like family; Region: NMT1_2; pfam13379
395963006290	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
395963006291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006292	active site
395963006293	phosphorylation site [posttranslational modification]
395963006294	intermolecular recognition site; other site
395963006295	ANTAR domain; Region: ANTAR; pfam03861
395963006296	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
395963006297	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
395963006298	molybdopterin cofactor binding site; other site
395963006299	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
395963006300	molybdopterin cofactor binding site; other site
395963006301	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
395963006302	Flavodoxin; Region: Flavodoxin_1; pfam00258
395963006303	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
395963006304	FAD binding pocket [chemical binding]; other site
395963006305	FAD binding motif [chemical binding]; other site
395963006306	catalytic residues [active]
395963006307	NAD binding pocket [chemical binding]; other site
395963006308	phosphate binding motif [ion binding]; other site
395963006309	beta-alpha-beta structure motif; other site
395963006310	nitrite reductase subunit NirD; Provisional; Region: PRK14989
395963006311	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963006312	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395963006313	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395963006314	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
395963006315	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
395963006316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006317	putative substrate translocation pore; other site
395963006318	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
395963006319	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
395963006320	heme-binding site [chemical binding]; other site
395963006321	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
395963006322	FAD binding pocket [chemical binding]; other site
395963006323	FAD binding motif [chemical binding]; other site
395963006324	phosphate binding motif [ion binding]; other site
395963006325	beta-alpha-beta structure motif; other site
395963006326	NAD binding pocket [chemical binding]; other site
395963006327	Heme binding  pocket [chemical binding]; other site
395963006328	Predicted transcriptional regulator [Transcription]; Region: COG1959
395963006329	Transcriptional regulator; Region: Rrf2; cl17282
395963006330	Part of AAA domain; Region: AAA_19; pfam13245
395963006331	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395963006332	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395963006333	AAA domain; Region: AAA_12; pfam13087
395963006334	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
395963006335	putative active site [active]
395963006336	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395963006337	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
395963006338	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
395963006339	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
395963006340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963006341	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
395963006342	dimer interface [polypeptide binding]; other site
395963006343	motif 1; other site
395963006344	active site
395963006345	motif 2; other site
395963006346	motif 3; other site
395963006347	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
395963006348	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395963006349	AsnC family; Region: AsnC_trans_reg; pfam01037
395963006350	PAS fold; Region: PAS_4; pfam08448
395963006351	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395963006352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006353	dimer interface [polypeptide binding]; other site
395963006354	phosphorylation site [posttranslational modification]
395963006355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006356	ATP binding site [chemical binding]; other site
395963006357	Mg2+ binding site [ion binding]; other site
395963006358	G-X-G motif; other site
395963006359	Response regulator receiver domain; Region: Response_reg; pfam00072
395963006360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006361	active site
395963006362	phosphorylation site [posttranslational modification]
395963006363	intermolecular recognition site; other site
395963006364	dimerization interface [polypeptide binding]; other site
395963006365	transport protein TonB; Provisional; Region: PRK10819
395963006366	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
395963006367	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395963006368	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
395963006369	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395963006370	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
395963006371	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
395963006372	substrate binding site [chemical binding]; other site
395963006373	active site
395963006374	catalytic residues [active]
395963006375	heterodimer interface [polypeptide binding]; other site
395963006376	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
395963006377	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
395963006378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963006379	catalytic residue [active]
395963006380	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963006381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963006382	DNA binding residues [nucleotide binding]
395963006383	dimerization interface [polypeptide binding]; other site
395963006384	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963006385	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963006386	DNA binding residues [nucleotide binding]
395963006387	dimerization interface [polypeptide binding]; other site
395963006388	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963006389	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963006390	DNA binding residues [nucleotide binding]
395963006391	dimerization interface [polypeptide binding]; other site
395963006392	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
395963006393	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
395963006394	MgtC family; Region: MgtC; pfam02308
395963006395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963006396	Coenzyme A binding pocket [chemical binding]; other site
395963006397	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890
395963006398	AAA domain; Region: AAA_22; pfam13401
395963006399	Uncharacterized conserved protein [Function unknown]; Region: COG4933
395963006400	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
395963006401	active site clefts [active]
395963006402	zinc binding site [ion binding]; other site
395963006403	dimer interface [polypeptide binding]; other site
395963006404	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395963006405	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395963006406	intersubunit interface [polypeptide binding]; other site
395963006407	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395963006408	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395963006409	ABC-ATPase subunit  interface; other site
395963006410	dimer interface [polypeptide binding]; other site
395963006411	putative PBP binding regions; other site
395963006412	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395963006413	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395963006414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006415	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963006416	putative substrate translocation pore; other site
395963006417	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395963006418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006419	putative substrate translocation pore; other site
395963006420	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
395963006421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963006422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963006423	S-adenosylmethionine binding site [chemical binding]; other site
395963006424	Putative integral membrane protein DUF46; Region: DUF46; cl17511
395963006425	comF family protein; Region: comF; TIGR00201
395963006426	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963006427	active site
395963006428	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395963006429	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
395963006430	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395963006431	FAD binding domain; Region: FAD_binding_4; pfam01565
395963006432	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
395963006433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963006434	S-adenosylmethionine binding site [chemical binding]; other site
395963006435	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395963006436	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395963006437	dimer interface [polypeptide binding]; other site
395963006438	hexamer interface [polypeptide binding]; other site
395963006439	active site 2 [active]
395963006440	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
395963006441	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
395963006442	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
395963006443	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
395963006444	substrate binding [chemical binding]; other site
395963006445	active site
395963006446	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
395963006447	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
395963006448	active site
395963006449	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
395963006450	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
395963006451	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
395963006452	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395963006453	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395963006454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006455	putative substrate translocation pore; other site
395963006456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006457	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
395963006458	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963006459	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963006460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963006461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963006462	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395963006463	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395963006464	Fe-S cluster binding site [ion binding]; other site
395963006465	active site
395963006466	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
395963006467	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
395963006468	putative dimer interface [polypeptide binding]; other site
395963006469	active site pocket [active]
395963006470	putative cataytic base [active]
395963006471	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963006472	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963006473	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963006474	substrate binding pocket [chemical binding]; other site
395963006475	membrane-bound complex binding site; other site
395963006476	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
395963006477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395963006478	PAS fold; Region: PAS_3; pfam08447
395963006479	putative active site [active]
395963006480	heme pocket [chemical binding]; other site
395963006481	PAS fold; Region: PAS_7; pfam12860
395963006482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963006483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006484	dimer interface [polypeptide binding]; other site
395963006485	phosphorylation site [posttranslational modification]
395963006486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006487	ATP binding site [chemical binding]; other site
395963006488	Mg2+ binding site [ion binding]; other site
395963006489	G-X-G motif; other site
395963006490	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
395963006491	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
395963006492	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395963006493	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395963006494	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
395963006495	30S ribosomal protein S13; Region: bact_S13; TIGR03631
395963006496	30S ribosomal protein S11; Validated; Region: PRK05309
395963006497	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
395963006498	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
395963006499	alphaNTD - beta interaction site [polypeptide binding]; other site
395963006500	alphaNTD homodimer interface [polypeptide binding]; other site
395963006501	alphaNTD - beta' interaction site [polypeptide binding]; other site
395963006502	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
395963006503	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
395963006504	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395963006505	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963006506	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963006507	protein binding site [polypeptide binding]; other site
395963006508	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963006509	protein binding site [polypeptide binding]; other site
395963006510	recombination factor protein RarA; Reviewed; Region: PRK13342
395963006511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963006512	Walker A motif; other site
395963006513	ATP binding site [chemical binding]; other site
395963006514	Walker B motif; other site
395963006515	arginine finger; other site
395963006516	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
395963006517	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963006518	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395963006519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963006520	active site
395963006521	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395963006522	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395963006523	ligand binding site [chemical binding]; other site
395963006524	flexible hinge region; other site
395963006525	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395963006526	putative switch regulator; other site
395963006527	non-specific DNA interactions [nucleotide binding]; other site
395963006528	DNA binding site [nucleotide binding]
395963006529	sequence specific DNA binding site [nucleotide binding]; other site
395963006530	putative cAMP binding site [chemical binding]; other site
395963006531	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395963006532	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395963006533	active site
395963006534	magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021
395963006535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395963006536	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395963006537	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
395963006538	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395963006539	active site
395963006540	dimer interface [polypeptide binding]; other site
395963006541	non-prolyl cis peptide bond; other site
395963006542	insertion regions; other site
395963006543	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963006544	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963006545	active site
395963006546	non-prolyl cis peptide bond; other site
395963006547	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395963006548	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
395963006549	Flavin binding site [chemical binding]; other site
395963006550	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395963006551	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395963006552	active site
395963006553	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395963006554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963006555	putative DNA binding site [nucleotide binding]; other site
395963006556	putative Zn2+ binding site [ion binding]; other site
395963006557	AsnC family; Region: AsnC_trans_reg; pfam01037
395963006558	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
395963006559	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395963006560	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963006561	Walker A/P-loop; other site
395963006562	ATP binding site [chemical binding]; other site
395963006563	Q-loop/lid; other site
395963006564	ABC transporter signature motif; other site
395963006565	Walker B; other site
395963006566	D-loop; other site
395963006567	H-loop/switch region; other site
395963006568	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963006569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963006570	dimer interface [polypeptide binding]; other site
395963006571	conserved gate region; other site
395963006572	putative PBP binding loops; other site
395963006573	ABC-ATPase subunit interface; other site
395963006574	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
395963006575	malic enzyme; Reviewed; Region: PRK12862
395963006576	Malic enzyme, N-terminal domain; Region: malic; pfam00390
395963006577	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
395963006578	putative NAD(P) binding site [chemical binding]; other site
395963006579	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
395963006580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
395963006581	DinB superfamily; Region: DinB_2; pfam12867
395963006582	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
395963006583	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963006584	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
395963006585	dimerization interface [polypeptide binding]; other site
395963006586	substrate binding pocket [chemical binding]; other site
395963006587	DNA gyrase, A subunit; Region: gyrA; TIGR01063
395963006588	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395963006589	CAP-like domain; other site
395963006590	active site
395963006591	primary dimer interface [polypeptide binding]; other site
395963006592	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395963006593	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395963006594	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395963006595	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395963006596	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395963006597	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
395963006598	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
395963006599	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395963006600	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395963006601	dimer interface [polypeptide binding]; other site
395963006602	ssDNA binding site [nucleotide binding]; other site
395963006603	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395963006604	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
395963006605	16S rRNA methyltransferase B; Provisional; Region: PRK10901
395963006606	NusB family; Region: NusB; pfam01029
395963006607	putative RNA binding site [nucleotide binding]; other site
395963006608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963006609	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
395963006610	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
395963006611	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963006612	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963006613	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
395963006614	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395963006615	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395963006616	intersubunit interface [polypeptide binding]; other site
395963006617	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395963006618	Predicted transporter component [General function prediction only]; Region: COG2391
395963006619	Predicted transporter component [General function prediction only]; Region: COG2391
395963006620	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395963006621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963006622	DNA-binding site [nucleotide binding]; DNA binding site
395963006623	FCD domain; Region: FCD; pfam07729
395963006624	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963006625	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
395963006626	putative NAD(P) binding site [chemical binding]; other site
395963006627	active site
395963006628	putative substrate binding site [chemical binding]; other site
395963006629	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395963006630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006631	putative substrate translocation pore; other site
395963006632	putative aldolase; Validated; Region: PRK08130
395963006633	intersubunit interface [polypeptide binding]; other site
395963006634	active site
395963006635	Zn2+ binding site [ion binding]; other site
395963006636	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395963006637	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395963006638	DNA binding site [nucleotide binding]
395963006639	domain linker motif; other site
395963006640	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
395963006641	putative dimerization interface [polypeptide binding]; other site
395963006642	putative ligand binding site [chemical binding]; other site
395963006643	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395963006644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006645	putative substrate translocation pore; other site
395963006646	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395963006647	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395963006648	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
395963006649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
395963006650	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963006651	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963006652	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963006653	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
395963006654	putative effector binding pocket; other site
395963006655	putative dimerization interface [polypeptide binding]; other site
395963006656	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395963006657	classical (c) SDRs; Region: SDR_c; cd05233
395963006658	NAD(P) binding site [chemical binding]; other site
395963006659	active site
395963006660	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
395963006661	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395963006662	FMN binding site [chemical binding]; other site
395963006663	substrate binding site [chemical binding]; other site
395963006664	putative catalytic residue [active]
395963006665	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
395963006666	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963006667	N-terminal plug; other site
395963006668	ligand-binding site [chemical binding]; other site
395963006669	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
395963006670	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
395963006671	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
395963006672	trimer interface [polypeptide binding]; other site
395963006673	putative metal binding site [ion binding]; other site
395963006674	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
395963006675	active site
395963006676	DNA polymerase IV; Validated; Region: PRK02406
395963006677	DNA binding site [nucleotide binding]
395963006678	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
395963006679	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395963006680	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395963006681	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395963006682	IucA / IucC family; Region: IucA_IucC; pfam04183
395963006683	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
395963006684	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
395963006685	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
395963006686	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
395963006687	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
395963006688	substrate binding site [chemical binding]; other site
395963006689	ligand binding site [chemical binding]; other site
395963006690	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395963006691	putative dimer interface [polypeptide binding]; other site
395963006692	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963006693	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
395963006694	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
395963006695	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963006696	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963006697	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
395963006698	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
395963006699	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
395963006700	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395963006701	catalytic residues [active]
395963006702	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
395963006703	active site
395963006704	catalytic residues [active]
395963006705	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
395963006706	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963006707	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963006708	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395963006709	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395963006710	Walker A/P-loop; other site
395963006711	ATP binding site [chemical binding]; other site
395963006712	Q-loop/lid; other site
395963006713	ABC transporter signature motif; other site
395963006714	Walker B; other site
395963006715	D-loop; other site
395963006716	H-loop/switch region; other site
395963006717	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395963006718	FtsX-like permease family; Region: FtsX; pfam02687
395963006719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963006720	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963006721	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395963006722	Pirin-related protein [General function prediction only]; Region: COG1741
395963006723	Pirin; Region: Pirin; pfam02678
395963006724	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
395963006725	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
395963006726	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
395963006727	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963006728	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
395963006729	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395963006730	DNA binding site [nucleotide binding]
395963006731	active site
395963006732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006733	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963006734	putative substrate translocation pore; other site
395963006735	Domain of unknown function (DUF336); Region: DUF336; pfam03928
395963006736	Major royal jelly protein; Region: MRJP; pfam03022
395963006737	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963006738	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
395963006739	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
395963006740	active site
395963006741	catalytic residue [active]
395963006742	dimer interface [polypeptide binding]; other site
395963006743	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
395963006744	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
395963006745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006746	putative substrate translocation pore; other site
395963006747	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
395963006748	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395963006749	active site
395963006750	oxyanion hole [active]
395963006751	catalytic triad [active]
395963006752	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395963006753	active site
395963006754	catalytic triad [active]
395963006755	oxyanion hole [active]
395963006756	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
395963006757	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395963006758	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395963006759	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
395963006760	arsenical-resistance protein; Region: acr3; TIGR00832
395963006761	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395963006762	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395963006763	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
395963006764	active site
395963006765	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963006766	dimerization interface [polypeptide binding]; other site
395963006767	putative Zn2+ binding site [ion binding]; other site
395963006768	putative DNA binding site [nucleotide binding]; other site
395963006769	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
395963006770	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395963006771	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963006772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963006773	motif II; other site
395963006774	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395963006775	CCC1; Region: CCC1; cd02435
395963006776	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
395963006777	active site
395963006778	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
395963006779	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395963006780	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395963006781	TolR protein; Region: tolR; TIGR02801
395963006782	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
395963006783	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963006784	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963006785	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395963006786	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963006787	Outer membrane efflux protein; Region: OEP; pfam02321
395963006788	Outer membrane efflux protein; Region: OEP; pfam02321
395963006789	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963006790	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963006791	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
395963006792	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963006793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963006794	active site
395963006795	phosphorylation site [posttranslational modification]
395963006796	intermolecular recognition site; other site
395963006797	dimerization interface [polypeptide binding]; other site
395963006798	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963006799	DNA binding site [nucleotide binding]
395963006800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963006801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963006802	dimer interface [polypeptide binding]; other site
395963006803	phosphorylation site [posttranslational modification]
395963006804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963006805	ATP binding site [chemical binding]; other site
395963006806	Mg2+ binding site [ion binding]; other site
395963006807	G-X-G motif; other site
395963006808	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395963006809	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
395963006810	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
395963006811	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
395963006812	dimer interface [polypeptide binding]; other site
395963006813	motif 1; other site
395963006814	active site
395963006815	motif 2; other site
395963006816	motif 3; other site
395963006817	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
395963006818	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395963006819	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395963006820	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
395963006821	active site
395963006822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963006823	FeS/SAM binding site; other site
395963006824	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395963006825	thiamine phosphate binding site [chemical binding]; other site
395963006826	active site
395963006827	pyrophosphate binding site [ion binding]; other site
395963006828	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
395963006829	ThiS interaction site; other site
395963006830	putative active site [active]
395963006831	tetramer interface [polypeptide binding]; other site
395963006832	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
395963006833	thiS-thiF/thiG interaction site; other site
395963006834	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
395963006835	putative glutathione S-transferase; Provisional; Region: PRK10357
395963006836	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
395963006837	putative C-terminal domain interface [polypeptide binding]; other site
395963006838	putative GSH binding site (G-site) [chemical binding]; other site
395963006839	putative dimer interface [polypeptide binding]; other site
395963006840	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
395963006841	dimer interface [polypeptide binding]; other site
395963006842	N-terminal domain interface [polypeptide binding]; other site
395963006843	putative substrate binding pocket (H-site) [chemical binding]; other site
395963006844	AAA domain; Region: AAA_23; pfam13476
395963006845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963006846	Walker A/P-loop; other site
395963006847	ATP binding site [chemical binding]; other site
395963006848	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
395963006849	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963006850	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963006851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963006852	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395963006853	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
395963006854	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
395963006855	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
395963006856	Family description; Region: UvrD_C_2; pfam13538
395963006857	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
395963006858	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395963006859	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395963006860	catalytic residues [active]
395963006861	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
395963006862	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963006863	FeS/SAM binding site; other site
395963006864	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
395963006865	active site
395963006866	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963006867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963006868	Isochorismatase family; Region: Isochorismatase; pfam00857
395963006869	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395963006870	catalytic triad [active]
395963006871	conserved cis-peptide bond; other site
395963006872	Putative ammonia monooxygenase; Region: AmoA; pfam05145
395963006873	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395963006874	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395963006875	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
395963006876	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395963006877	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395963006878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963006879	Walker A motif; other site
395963006880	ATP binding site [chemical binding]; other site
395963006881	Walker B motif; other site
395963006882	arginine finger; other site
395963006883	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
395963006884	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
395963006885	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
395963006886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963006887	Walker A motif; other site
395963006888	ATP binding site [chemical binding]; other site
395963006889	Walker B motif; other site
395963006890	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395963006891	Clp protease; Region: CLP_protease; pfam00574
395963006892	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395963006893	oligomer interface [polypeptide binding]; other site
395963006894	active site residues [active]
395963006895	trigger factor; Provisional; Region: tig; PRK01490
395963006896	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395963006897	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
395963006898	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395963006899	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395963006900	Multicopper oxidase; Region: Cu-oxidase; pfam00394
395963006901	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395963006902	Putative ParB-like nuclease; Region: ParBc_2; cl17538
395963006903	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395963006904	EamA-like transporter family; Region: EamA; pfam00892
395963006905	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395963006906	active site
395963006907	oxyanion hole [active]
395963006908	catalytic triad [active]
395963006909	OpgC protein; Region: OpgC_C; pfam10129
395963006910	putative carbohydrate kinase; Provisional; Region: PRK10565
395963006911	Uncharacterized conserved protein [Function unknown]; Region: COG0062
395963006912	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
395963006913	putative substrate binding site [chemical binding]; other site
395963006914	putative ATP binding site [chemical binding]; other site
395963006915	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
395963006916	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395963006917	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395963006918	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395963006919	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
395963006920	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
395963006921	catalytic residues [active]
395963006922	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
395963006923	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395963006924	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963006925	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
395963006926	dimer interface [polypeptide binding]; other site
395963006927	substrate binding site [chemical binding]; other site
395963006928	metal binding site [ion binding]; metal-binding site
395963006929	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
395963006930	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
395963006931	active site
395963006932	substrate binding site [chemical binding]; other site
395963006933	coenzyme B12 binding site [chemical binding]; other site
395963006934	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
395963006935	B12 binding site [chemical binding]; other site
395963006936	cobalt ligand [ion binding]; other site
395963006937	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
395963006938	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
395963006939	heterodimer interface [polypeptide binding]; other site
395963006940	substrate interaction site [chemical binding]; other site
395963006941	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
395963006942	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395963006943	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395963006944	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
395963006945	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
395963006946	dimer interaction site [polypeptide binding]; other site
395963006947	substrate-binding tunnel; other site
395963006948	active site
395963006949	catalytic site [active]
395963006950	substrate binding site [chemical binding]; other site
395963006951	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
395963006952	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
395963006953	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
395963006954	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963006955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
395963006956	motif II; other site
395963006957	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395963006958	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395963006959	putative phosphoketolase; Provisional; Region: PRK05261
395963006960	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
395963006961	TPP-binding site; other site
395963006962	XFP C-terminal domain; Region: XFP_C; pfam09363
395963006963	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
395963006964	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
395963006965	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
395963006966	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
395963006967	RNA binding site [nucleotide binding]; other site
395963006968	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395963006969	Sulfatase; Region: Sulfatase; pfam00884
395963006970	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395963006971	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963006972	DNA-binding site [nucleotide binding]; DNA binding site
395963006973	FCD domain; Region: FCD; pfam07729
395963006974	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
395963006975	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
395963006976	MOFRL family; Region: MOFRL; pfam05161
395963006977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963006978	D-galactonate transporter; Region: 2A0114; TIGR00893
395963006979	putative substrate translocation pore; other site
395963006980	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
395963006981	CoA-transferase family III; Region: CoA_transf_3; pfam02515
395963006982	enoyl-CoA hydratase; Provisional; Region: PRK06144
395963006983	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963006984	substrate binding site [chemical binding]; other site
395963006985	oxyanion hole (OAH) forming residues; other site
395963006986	trimer interface [polypeptide binding]; other site
395963006987	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
395963006988	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395963006989	MarR family; Region: MarR_2; pfam12802
395963006990	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
395963006991	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395963006992	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
395963006993	putative NAD(P) binding site [chemical binding]; other site
395963006994	catalytic Zn binding site [ion binding]; other site
395963006995	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395963006996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963006997	Walker A motif; other site
395963006998	ATP binding site [chemical binding]; other site
395963006999	Walker B motif; other site
395963007000	arginine finger; other site
395963007001	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963007002	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
395963007003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963007004	active site
395963007005	motif I; other site
395963007006	motif II; other site
395963007007	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395963007008	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963007009	Ligand Binding Site [chemical binding]; other site
395963007010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
395963007011	Predicted kinase [General function prediction only]; Region: COG0645
395963007012	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395963007013	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
395963007014	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
395963007015	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
395963007016	rRNA interaction site [nucleotide binding]; other site
395963007017	S8 interaction site; other site
395963007018	putative laminin-1 binding site; other site
395963007019	Uncharacterized conserved protein [Function unknown]; Region: COG3743
395963007020	elongation factor Ts; Provisional; Region: tsf; PRK09377
395963007021	UBA/TS-N domain; Region: UBA; pfam00627
395963007022	Elongation factor TS; Region: EF_TS; pfam00889
395963007023	Elongation factor TS; Region: EF_TS; pfam00889
395963007024	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
395963007025	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395963007026	nucleotide binding site [chemical binding]; other site
395963007027	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
395963007028	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963007029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963007030	active site
395963007031	phosphorylation site [posttranslational modification]
395963007032	intermolecular recognition site; other site
395963007033	dimerization interface [polypeptide binding]; other site
395963007034	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963007035	DNA binding site [nucleotide binding]
395963007036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963007037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963007038	ATP binding site [chemical binding]; other site
395963007039	Mg2+ binding site [ion binding]; other site
395963007040	G-X-G motif; other site
395963007041	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
395963007042	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
395963007043	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
395963007044	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
395963007045	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
395963007046	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395963007047	Domain of unknown function DUF21; Region: DUF21; pfam01595
395963007048	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395963007049	Transporter associated domain; Region: CorC_HlyC; smart01091
395963007050	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395963007051	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963007052	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963007053	protein binding site [polypeptide binding]; other site
395963007054	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395963007055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963007056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963007057	active site
395963007058	phosphorylation site [posttranslational modification]
395963007059	intermolecular recognition site; other site
395963007060	dimerization interface [polypeptide binding]; other site
395963007061	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963007062	DNA binding site [nucleotide binding]
395963007063	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963007064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395963007065	dimerization interface [polypeptide binding]; other site
395963007066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963007067	dimer interface [polypeptide binding]; other site
395963007068	phosphorylation site [posttranslational modification]
395963007069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963007070	ATP binding site [chemical binding]; other site
395963007071	Mg2+ binding site [ion binding]; other site
395963007072	G-X-G motif; other site
395963007073	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
395963007074	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395963007075	metal binding triad; other site
395963007076	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395963007077	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395963007078	metal binding triad; other site
395963007079	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
395963007080	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395963007081	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
395963007082	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395963007083	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395963007084	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
395963007085	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395963007086	Glucose inhibited division protein A; Region: GIDA; pfam01134
395963007087	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
395963007088	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
395963007089	UbiA prenyltransferase family; Region: UbiA; pfam01040
395963007090	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
395963007091	Porin subfamily; Region: Porin_2; pfam02530
395963007092	glutamate--cysteine ligase; Region: PLN02611
395963007093	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
395963007094	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395963007095	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
395963007096	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395963007097	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
395963007098	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395963007099	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
395963007100	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
395963007101	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
395963007102	Walker A/P-loop; other site
395963007103	ATP binding site [chemical binding]; other site
395963007104	Q-loop/lid; other site
395963007105	ABC transporter signature motif; other site
395963007106	Walker B; other site
395963007107	D-loop; other site
395963007108	H-loop/switch region; other site
395963007109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007110	dimer interface [polypeptide binding]; other site
395963007111	conserved gate region; other site
395963007112	putative PBP binding loops; other site
395963007113	ABC-ATPase subunit interface; other site
395963007114	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395963007115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007116	dimer interface [polypeptide binding]; other site
395963007117	conserved gate region; other site
395963007118	putative PBP binding loops; other site
395963007119	ABC-ATPase subunit interface; other site
395963007120	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
395963007121	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
395963007122	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395963007123	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395963007124	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
395963007125	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395963007126	Active Sites [active]
395963007127	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
395963007128	Predicted metalloprotease [General function prediction only]; Region: COG2321
395963007129	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
395963007130	Cupin domain; Region: Cupin_2; cl17218
395963007131	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395963007132	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395963007133	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395963007134	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395963007135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
395963007136	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
395963007137	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963007138	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395963007139	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395963007140	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
395963007141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963007143	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007144	Protein of unknown function (DUF422); Region: DUF422; cl00991
395963007145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
395963007146	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
395963007147	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963007148	Serine hydrolase; Region: Ser_hydrolase; cl17834
395963007149	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963007150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963007151	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395963007152	Coenzyme A binding pocket [chemical binding]; other site
395963007153	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395963007154	putative hydrophobic ligand binding site [chemical binding]; other site
395963007155	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
395963007156	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
395963007157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963007158	Walker A/P-loop; other site
395963007159	ATP binding site [chemical binding]; other site
395963007160	Q-loop/lid; other site
395963007161	ABC transporter signature motif; other site
395963007162	Walker B; other site
395963007163	D-loop; other site
395963007164	H-loop/switch region; other site
395963007165	TOBE domain; Region: TOBE; cl01440
395963007166	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395963007167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007168	dimer interface [polypeptide binding]; other site
395963007169	conserved gate region; other site
395963007170	putative PBP binding loops; other site
395963007171	ABC-ATPase subunit interface; other site
395963007172	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395963007173	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395963007174	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395963007175	dimerization interface [polypeptide binding]; other site
395963007176	metal binding site [ion binding]; metal-binding site
395963007177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
395963007178	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395963007179	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395963007180	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395963007181	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
395963007182	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395963007183	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963007184	FeS/SAM binding site; other site
395963007185	YceG-like family; Region: YceG; pfam02618
395963007186	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
395963007187	dimerization interface [polypeptide binding]; other site
395963007188	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
395963007189	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395963007190	dimer interface [polypeptide binding]; other site
395963007191	active site
395963007192	acyl carrier protein; Provisional; Region: acpP; PRK00982
395963007193	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395963007194	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
395963007195	NAD(P) binding site [chemical binding]; other site
395963007196	homotetramer interface [polypeptide binding]; other site
395963007197	homodimer interface [polypeptide binding]; other site
395963007198	active site
395963007199	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
395963007200	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395963007201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007202	putative substrate translocation pore; other site
395963007203	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395963007204	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
395963007205	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
395963007206	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
395963007207	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
395963007208	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
395963007209	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
395963007210	replicative DNA helicase; Provisional; Region: PRK09165
395963007211	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
395963007212	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
395963007213	Walker A motif; other site
395963007214	ATP binding site [chemical binding]; other site
395963007215	Walker B motif; other site
395963007216	DNA binding loops [nucleotide binding]
395963007217	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
395963007218	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
395963007219	active site
395963007220	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395963007221	dimer interface [polypeptide binding]; other site
395963007222	substrate binding site [chemical binding]; other site
395963007223	catalytic residues [active]
395963007224	DNA repair protein RadA; Provisional; Region: PRK11823
395963007225	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963007226	Walker A motif; other site
395963007227	ATP binding site [chemical binding]; other site
395963007228	Walker B motif; other site
395963007229	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395963007230	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
395963007231	Colicin V production protein; Region: Colicin_V; pfam02674
395963007232	amidophosphoribosyltransferase; Provisional; Region: PRK09123
395963007233	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
395963007234	active site
395963007235	tetramer interface [polypeptide binding]; other site
395963007236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395963007237	active site
395963007238	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
395963007239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963007240	NAD(P) binding site [chemical binding]; other site
395963007241	active site
395963007242	Divergent AAA domain; Region: AAA_4; pfam04326
395963007243	GTP-binding protein Der; Reviewed; Region: PRK00093
395963007244	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
395963007245	G1 box; other site
395963007246	GTP/Mg2+ binding site [chemical binding]; other site
395963007247	Switch I region; other site
395963007248	G2 box; other site
395963007249	Switch II region; other site
395963007250	G3 box; other site
395963007251	G4 box; other site
395963007252	G5 box; other site
395963007253	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
395963007254	G1 box; other site
395963007255	GTP/Mg2+ binding site [chemical binding]; other site
395963007256	Switch I region; other site
395963007257	G2 box; other site
395963007258	G3 box; other site
395963007259	Switch II region; other site
395963007260	G4 box; other site
395963007261	G5 box; other site
395963007262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
395963007263	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395963007264	MarR family; Region: MarR_2; pfam12802
395963007265	Fusaric acid resistance protein family; Region: FUSC; pfam04632
395963007266	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395963007267	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
395963007268	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
395963007269	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963007270	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963007271	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
395963007272	SnoaL-like domain; Region: SnoaL_3; pfam13474
395963007273	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
395963007274	amphipathic channel; other site
395963007275	Asn-Pro-Ala signature motifs; other site
395963007276	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395963007277	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395963007278	intersubunit interface [polypeptide binding]; other site
395963007279	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
395963007280	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963007281	N-terminal plug; other site
395963007282	ligand-binding site [chemical binding]; other site
395963007283	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
395963007284	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395963007285	Walker A/P-loop; other site
395963007286	ATP binding site [chemical binding]; other site
395963007287	Q-loop/lid; other site
395963007288	ABC transporter signature motif; other site
395963007289	Walker B; other site
395963007290	D-loop; other site
395963007291	H-loop/switch region; other site
395963007292	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395963007293	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395963007294	ABC-ATPase subunit  interface; other site
395963007295	dimer interface [polypeptide binding]; other site
395963007296	putative PBP binding regions; other site
395963007297	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395963007298	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395963007299	intersubunit interface [polypeptide binding]; other site
395963007300	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395963007301	apolar tunnel; other site
395963007302	heme binding site [chemical binding]; other site
395963007303	dimerization interface [polypeptide binding]; other site
395963007304	Uncharacterized conserved protein [Function unknown]; Region: COG1359
395963007305	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
395963007306	RNA/DNA hybrid binding site [nucleotide binding]; other site
395963007307	active site
395963007308	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
395963007309	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
395963007310	putative active site [active]
395963007311	putative substrate binding site [chemical binding]; other site
395963007312	ATP binding site [chemical binding]; other site
395963007313	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
395963007314	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
395963007315	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
395963007316	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
395963007317	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395963007318	active site
395963007319	short chain dehydrogenase; Provisional; Region: PRK06523
395963007320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963007321	NAD(P) binding site [chemical binding]; other site
395963007322	active site
395963007323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963007324	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963007325	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963007326	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963007327	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
395963007328	putative ligand binding site [chemical binding]; other site
395963007329	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
395963007330	L-idonate 5-dehydrogenase; Region: PLN02702
395963007331	inhibitor binding site; inhibition site
395963007332	catalytic Zn binding site [ion binding]; other site
395963007333	structural Zn binding site [ion binding]; other site
395963007334	NADP binding site [chemical binding]; other site
395963007335	tetramer interface [polypeptide binding]; other site
395963007336	Domain of unknown function (DUF336); Region: DUF336; cl01249
395963007337	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395963007338	active site
395963007339	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
395963007340	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964
395963007341	active site
395963007342	(T/H)XGH motif; other site
395963007343	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395963007344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963007345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963007346	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963007347	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963007348	catalytic loop [active]
395963007349	iron binding site [ion binding]; other site
395963007350	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
395963007351	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
395963007352	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395963007353	amidase catalytic site [active]
395963007354	Zn binding residues [ion binding]; other site
395963007355	substrate binding site [chemical binding]; other site
395963007356	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963007357	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963007359	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395963007360	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395963007361	C-terminal domain interface [polypeptide binding]; other site
395963007362	GSH binding site (G-site) [chemical binding]; other site
395963007363	dimer interface [polypeptide binding]; other site
395963007364	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
395963007365	N-terminal domain interface [polypeptide binding]; other site
395963007366	putative dimer interface [polypeptide binding]; other site
395963007367	active site
395963007368	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
395963007369	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963007370	putative C-terminal domain interface [polypeptide binding]; other site
395963007371	putative GSH binding site (G-site) [chemical binding]; other site
395963007372	putative dimer interface [polypeptide binding]; other site
395963007373	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
395963007374	putative N-terminal domain interface [polypeptide binding]; other site
395963007375	putative dimer interface [polypeptide binding]; other site
395963007376	putative substrate binding pocket (H-site) [chemical binding]; other site
395963007377	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
395963007378	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
395963007379	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395963007380	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
395963007381	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
395963007382	Na binding site [ion binding]; other site
395963007383	putative acetyltransferase YhhY; Provisional; Region: PRK10140
395963007384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963007385	Coenzyme A binding pocket [chemical binding]; other site
395963007386	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963007387	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963007388	substrate binding pocket [chemical binding]; other site
395963007389	membrane-bound complex binding site; other site
395963007390	hinge residues; other site
395963007391	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395963007392	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
395963007393	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
395963007394	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395963007395	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
395963007396	active site
395963007397	dimer interface [polypeptide binding]; other site
395963007398	motif 1; other site
395963007399	motif 2; other site
395963007400	motif 3; other site
395963007401	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
395963007402	anticodon binding site; other site
395963007403	Uncharacterized conserved protein [Function unknown]; Region: COG3025
395963007404	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
395963007405	putative active site [active]
395963007406	putative metal binding residues [ion binding]; other site
395963007407	signature motif; other site
395963007408	putative triphosphate binding site [ion binding]; other site
395963007409	CHAD domain; Region: CHAD; pfam05235
395963007410	BA14K-like protein; Region: BA14K; pfam07886
395963007411	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
395963007412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007413	putative substrate translocation pore; other site
395963007414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007415	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395963007416	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963007417	RNA binding surface [nucleotide binding]; other site
395963007418	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
395963007419	active site
395963007420	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395963007421	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395963007422	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
395963007423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963007424	S-adenosylmethionine binding site [chemical binding]; other site
395963007425	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395963007426	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963007427	N-terminal plug; other site
395963007428	ligand-binding site [chemical binding]; other site
395963007429	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
395963007430	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
395963007431	Cu(I) binding site [ion binding]; other site
395963007432	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
395963007433	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963007434	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
395963007435	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
395963007436	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
395963007437	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
395963007438	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
395963007439	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395963007440	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
395963007441	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395963007442	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
395963007443	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
395963007444	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395963007445	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
395963007446	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
395963007447	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
395963007448	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
395963007449	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
395963007450	4Fe-4S binding domain; Region: Fer4; pfam00037
395963007451	4Fe-4S binding domain; Region: Fer4; pfam00037
395963007452	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
395963007453	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
395963007454	NADH dehydrogenase subunit G; Validated; Region: PRK09130
395963007455	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963007456	catalytic loop [active]
395963007457	iron binding site [ion binding]; other site
395963007458	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395963007459	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
395963007460	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
395963007461	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
395963007462	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
395963007463	SLBB domain; Region: SLBB; pfam10531
395963007464	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395963007465	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
395963007466	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
395963007467	putative dimer interface [polypeptide binding]; other site
395963007468	[2Fe-2S] cluster binding site [ion binding]; other site
395963007469	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395963007470	NADH dehydrogenase subunit D; Validated; Region: PRK06075
395963007471	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
395963007472	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
395963007473	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
395963007474	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
395963007475	Predicted periplasmic protein [Function unknown]; Region: COG3904
395963007476	recombinase A; Provisional; Region: recA; PRK09354
395963007477	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
395963007478	hexamer interface [polypeptide binding]; other site
395963007479	Walker A motif; other site
395963007480	ATP binding site [chemical binding]; other site
395963007481	Walker B motif; other site
395963007482	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395963007483	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
395963007484	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
395963007485	motif 1; other site
395963007486	active site
395963007487	motif 2; other site
395963007488	motif 3; other site
395963007489	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395963007490	Phasin protein; Region: Phasin_2; pfam09361
395963007491	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
395963007492	catalytic core [active]
395963007493	YcjX-like family, DUF463; Region: DUF463; pfam04317
395963007494	hypothetical protein; Provisional; Region: PRK05415
395963007495	Domain of unknown function (DUF697); Region: DUF697; cl12064
395963007496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963007497	non-specific DNA binding site [nucleotide binding]; other site
395963007498	salt bridge; other site
395963007499	sequence-specific DNA binding site [nucleotide binding]; other site
395963007500	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
395963007501	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
395963007502	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
395963007503	Cl binding site [ion binding]; other site
395963007504	oligomer interface [polypeptide binding]; other site
395963007505	ketol-acid reductoisomerase; Provisional; Region: PRK05479
395963007506	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
395963007507	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
395963007508	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
395963007509	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
395963007510	putative valine binding site [chemical binding]; other site
395963007511	dimer interface [polypeptide binding]; other site
395963007512	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
395963007513	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
395963007514	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395963007515	PYR/PP interface [polypeptide binding]; other site
395963007516	dimer interface [polypeptide binding]; other site
395963007517	TPP binding site [chemical binding]; other site
395963007518	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395963007519	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
395963007520	TPP-binding site [chemical binding]; other site
395963007521	dimer interface [polypeptide binding]; other site
395963007522	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963007523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963007524	non-specific DNA binding site [nucleotide binding]; other site
395963007525	salt bridge; other site
395963007526	sequence-specific DNA binding site [nucleotide binding]; other site
395963007527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963007528	S-adenosylmethionine binding site [chemical binding]; other site
395963007529	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
395963007530	putative deacylase active site [active]
395963007531	manganese transport regulator MntR; Provisional; Region: PRK11050
395963007532	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963007533	DNA-binding site [nucleotide binding]; DNA binding site
395963007534	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
395963007535	manganese transport protein MntH; Reviewed; Region: PRK00701
395963007536	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
395963007537	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395963007538	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963007539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963007540	ABC transporter; Region: ABC_tran_2; pfam12848
395963007541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963007542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
395963007543	Putative glucoamylase; Region: Glycoamylase; pfam10091
395963007544	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395963007545	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
395963007546	dimer interface [polypeptide binding]; other site
395963007547	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395963007548	catalytic triad [active]
395963007549	peroxidatic and resolving cysteines [active]
395963007550	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
395963007551	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395963007552	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
395963007553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963007554	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
395963007555	dimerization interface [polypeptide binding]; other site
395963007556	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
395963007557	active site
395963007558	multimer interface [polypeptide binding]; other site
395963007559	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395963007560	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
395963007561	active site
395963007562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007563	D-galactonate transporter; Region: 2A0114; TIGR00893
395963007564	putative substrate translocation pore; other site
395963007565	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395963007566	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395963007567	Walker A/P-loop; other site
395963007568	ATP binding site [chemical binding]; other site
395963007569	Q-loop/lid; other site
395963007570	ABC transporter signature motif; other site
395963007571	Walker B; other site
395963007572	D-loop; other site
395963007573	H-loop/switch region; other site
395963007574	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395963007575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007576	dimer interface [polypeptide binding]; other site
395963007577	conserved gate region; other site
395963007578	putative PBP binding loops; other site
395963007579	ABC-ATPase subunit interface; other site
395963007580	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963007581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963007582	substrate binding pocket [chemical binding]; other site
395963007583	membrane-bound complex binding site; other site
395963007584	hinge residues; other site
395963007585	FOG: CBS domain [General function prediction only]; Region: COG0517
395963007586	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
395963007587	GTPase Era; Reviewed; Region: era; PRK00089
395963007588	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
395963007589	G1 box; other site
395963007590	GTP/Mg2+ binding site [chemical binding]; other site
395963007591	Switch I region; other site
395963007592	G2 box; other site
395963007593	Switch II region; other site
395963007594	G3 box; other site
395963007595	G4 box; other site
395963007596	G5 box; other site
395963007597	KH domain; Region: KH_2; pfam07650
395963007598	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
395963007599	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
395963007600	dimerization interface [polypeptide binding]; other site
395963007601	active site
395963007602	metal binding site [ion binding]; metal-binding site
395963007603	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
395963007604	dsRNA binding site [nucleotide binding]; other site
395963007605	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
395963007606	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395963007607	Catalytic site [active]
395963007608	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395963007609	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
395963007610	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
395963007611	active site
395963007612	hydrophilic channel; other site
395963007613	dimerization interface [polypeptide binding]; other site
395963007614	catalytic residues [active]
395963007615	active site lid [active]
395963007616	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395963007617	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395963007618	Zn2+ binding site [ion binding]; other site
395963007619	Mg2+ binding site [ion binding]; other site
395963007620	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
395963007621	synthetase active site [active]
395963007622	NTP binding site [chemical binding]; other site
395963007623	metal binding site [ion binding]; metal-binding site
395963007624	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
395963007625	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
395963007626	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
395963007627	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395963007628	LabA_like proteins; Region: LabA; cd10911
395963007629	putative metal binding site [ion binding]; other site
395963007630	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
395963007631	Fe-S cluster binding site [ion binding]; other site
395963007632	DNA binding site [nucleotide binding]
395963007633	active site
395963007634	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963007635	Protein export membrane protein; Region: SecD_SecF; cl14618
395963007636	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963007637	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963007638	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963007639	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
395963007640	phosphate acetyltransferase; Provisional; Region: PRK11890
395963007641	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
395963007642	Peptidase family M48; Region: Peptidase_M48; pfam01435
395963007643	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
395963007644	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
395963007645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007646	dimer interface [polypeptide binding]; other site
395963007647	conserved gate region; other site
395963007648	ABC-ATPase subunit interface; other site
395963007649	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
395963007650	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
395963007651	Walker A/P-loop; other site
395963007652	ATP binding site [chemical binding]; other site
395963007653	Q-loop/lid; other site
395963007654	ABC transporter signature motif; other site
395963007655	Walker B; other site
395963007656	D-loop; other site
395963007657	H-loop/switch region; other site
395963007658	NIL domain; Region: NIL; pfam09383
395963007659	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
395963007660	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
395963007661	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
395963007662	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
395963007663	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
395963007664	Walker A/P-loop; other site
395963007665	ATP binding site [chemical binding]; other site
395963007666	Q-loop/lid; other site
395963007667	ABC transporter signature motif; other site
395963007668	Walker B; other site
395963007669	D-loop; other site
395963007670	H-loop/switch region; other site
395963007671	TOBE domain; Region: TOBE_2; pfam08402
395963007672	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
395963007673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007674	dimer interface [polypeptide binding]; other site
395963007675	conserved gate region; other site
395963007676	putative PBP binding loops; other site
395963007677	ABC-ATPase subunit interface; other site
395963007678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007679	dimer interface [polypeptide binding]; other site
395963007680	conserved gate region; other site
395963007681	putative PBP binding loops; other site
395963007682	ABC-ATPase subunit interface; other site
395963007683	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
395963007684	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
395963007685	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
395963007686	N- and C-terminal domain interface [polypeptide binding]; other site
395963007687	D-xylulose kinase; Region: XylB; TIGR01312
395963007688	active site
395963007689	MgATP binding site [chemical binding]; other site
395963007690	catalytic site [active]
395963007691	metal binding site [ion binding]; metal-binding site
395963007692	xylulose binding site [chemical binding]; other site
395963007693	homodimer interface [polypeptide binding]; other site
395963007694	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395963007695	putative active site pocket [active]
395963007696	dimerization interface [polypeptide binding]; other site
395963007697	putative catalytic residue [active]
395963007698	Rdx family; Region: Rdx; cl01407
395963007699	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395963007700	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395963007701	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395963007702	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395963007703	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395963007704	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395963007705	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
395963007706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
395963007707	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
395963007708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963007709	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
395963007710	putative dimerization interface [polypeptide binding]; other site
395963007711	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
395963007712	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
395963007713	gating phenylalanine in ion channel; other site
395963007714	hydrogenase 4 subunit B; Validated; Region: PRK06521
395963007715	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395963007716	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
395963007717	NADH dehydrogenase; Region: NADHdh; cl00469
395963007718	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
395963007719	hydrogenase 4 subunit F; Validated; Region: PRK06458
395963007720	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395963007721	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
395963007722	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
395963007723	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
395963007724	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
395963007725	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
395963007726	DNA binding site [nucleotide binding]
395963007727	dimer interface [polypeptide binding]; other site
395963007728	Int/Topo IB signature motif; other site
395963007729	active site
395963007730	Transcriptional regulators [Transcription]; Region: PurR; COG1609
395963007731	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395963007732	DNA binding site [nucleotide binding]
395963007733	domain linker motif; other site
395963007734	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
395963007735	dimerization interface [polypeptide binding]; other site
395963007736	ligand binding site [chemical binding]; other site
395963007737	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395963007738	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395963007739	substrate binding site [chemical binding]; other site
395963007740	ATP binding site [chemical binding]; other site
395963007741	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
395963007742	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395963007743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963007744	motif II; other site
395963007745	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
395963007746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007747	putative substrate translocation pore; other site
395963007748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007749	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
395963007750	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963007751	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395963007752	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395963007753	putative ligand binding site [chemical binding]; other site
395963007754	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
395963007755	[2Fe-2S] cluster binding site [ion binding]; other site
395963007756	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395963007757	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395963007758	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963007759	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395963007760	DNA binding site [nucleotide binding]
395963007761	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
395963007762	putative ligand binding site [chemical binding]; other site
395963007763	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
395963007764	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963007765	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395963007766	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963007767	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
395963007768	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
395963007769	substrate binding site [chemical binding]; other site
395963007770	catalytic Zn binding site [ion binding]; other site
395963007771	NAD binding site [chemical binding]; other site
395963007772	structural Zn binding site [ion binding]; other site
395963007773	dimer interface [polypeptide binding]; other site
395963007774	S-formylglutathione hydrolase; Region: PLN02442
395963007775	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
395963007776	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
395963007777	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395963007778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963007779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963007780	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
395963007781	putative substrate binding pocket [chemical binding]; other site
395963007782	putative dimerization interface [polypeptide binding]; other site
395963007783	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395963007784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007785	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395963007786	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963007787	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963007788	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395963007789	Predicted transcriptional regulators [Transcription]; Region: COG1695
395963007790	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395963007791	RNA polymerase factor sigma-70; Validated; Region: PRK08241
395963007792	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963007793	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963007794	DNA binding residues [nucleotide binding]
395963007795	SnoaL-like domain; Region: SnoaL_2; pfam12680
395963007796	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395963007797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963007798	NAD(P) binding site [chemical binding]; other site
395963007799	active site
395963007800	chaperone protein HchA; Provisional; Region: PRK04155
395963007801	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
395963007802	conserved cys residue [active]
395963007803	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
395963007804	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395963007805	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963007806	DNA binding residues [nucleotide binding]
395963007807	dimerization interface [polypeptide binding]; other site
395963007808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963007809	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
395963007810	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395963007811	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
395963007812	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
395963007813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963007815	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963007816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963007817	NAD(P) binding site [chemical binding]; other site
395963007818	active site
395963007819	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395963007820	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
395963007821	Walker A/P-loop; other site
395963007822	ATP binding site [chemical binding]; other site
395963007823	Q-loop/lid; other site
395963007824	ABC transporter signature motif; other site
395963007825	Walker B; other site
395963007826	D-loop; other site
395963007827	H-loop/switch region; other site
395963007828	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
395963007829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007830	dimer interface [polypeptide binding]; other site
395963007831	conserved gate region; other site
395963007832	putative PBP binding loops; other site
395963007833	ABC-ATPase subunit interface; other site
395963007834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007835	dimer interface [polypeptide binding]; other site
395963007836	conserved gate region; other site
395963007837	putative PBP binding loops; other site
395963007838	ABC-ATPase subunit interface; other site
395963007839	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395963007840	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395963007841	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
395963007842	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
395963007843	Chromate transporter; Region: Chromate_transp; pfam02417
395963007844	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
395963007845	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
395963007846	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
395963007847	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
395963007848	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395963007849	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395963007850	amino acid transporter; Region: 2A0306; TIGR00909
395963007851	Spore germination protein; Region: Spore_permease; cl17796
395963007852	IucA / IucC family; Region: IucA_IucC; pfam04183
395963007853	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
395963007854	High-affinity nickel-transport protein; Region: NicO; cl00964
395963007855	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
395963007856	putative active site [active]
395963007857	putative catalytic site [active]
395963007858	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395963007859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007860	metabolite-proton symporter; Region: 2A0106; TIGR00883
395963007861	putative substrate translocation pore; other site
395963007862	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
395963007863	CoA-transferase family III; Region: CoA_transf_3; pfam02515
395963007864	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963007865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963007866	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
395963007867	putative dimerization interface [polypeptide binding]; other site
395963007868	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395963007869	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395963007870	oligomeric interface; other site
395963007871	putative active site [active]
395963007872	homodimer interface [polypeptide binding]; other site
395963007873	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963007874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963007875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963007876	dimerization interface [polypeptide binding]; other site
395963007877	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
395963007878	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395963007879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007880	putative substrate translocation pore; other site
395963007881	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
395963007882	Porin subfamily; Region: Porin_2; pfam02530
395963007883	isocitrate dehydrogenase; Validated; Region: PRK08299
395963007884	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395963007885	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
395963007886	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
395963007887	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
395963007888	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
395963007889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007890	dimer interface [polypeptide binding]; other site
395963007891	conserved gate region; other site
395963007892	putative PBP binding loops; other site
395963007893	ABC-ATPase subunit interface; other site
395963007894	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
395963007895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963007896	dimer interface [polypeptide binding]; other site
395963007897	conserved gate region; other site
395963007898	putative PBP binding loops; other site
395963007899	ABC-ATPase subunit interface; other site
395963007900	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
395963007901	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
395963007902	Flavin binding site [chemical binding]; other site
395963007903	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395963007904	active site residue [active]
395963007905	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395963007906	active site residue [active]
395963007907	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395963007908	active site residue [active]
395963007909	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
395963007910	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963007911	Walker A/P-loop; other site
395963007912	ATP binding site [chemical binding]; other site
395963007913	Q-loop/lid; other site
395963007914	ABC transporter signature motif; other site
395963007915	Walker B; other site
395963007916	D-loop; other site
395963007917	H-loop/switch region; other site
395963007918	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395963007919	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
395963007920	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963007921	Walker A/P-loop; other site
395963007922	ATP binding site [chemical binding]; other site
395963007923	Q-loop/lid; other site
395963007924	ABC transporter signature motif; other site
395963007925	Walker B; other site
395963007926	D-loop; other site
395963007927	H-loop/switch region; other site
395963007928	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
395963007929	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963007930	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963007931	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963007932	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963007933	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963007934	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963007935	active site
395963007936	non-prolyl cis peptide bond; other site
395963007937	Winged helix-turn helix; Region: HTH_29; pfam13551
395963007938	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963007940	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
395963007941	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395963007942	dimer interface [polypeptide binding]; other site
395963007943	active site
395963007944	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963007945	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963007946	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963007947	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963007948	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963007949	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963007950	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963007951	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
395963007952	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
395963007953	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
395963007954	active site
395963007955	non-prolyl cis peptide bond; other site
395963007956	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963007957	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963007958	active site
395963007959	catalytic tetrad [active]
395963007960	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
395963007961	Transposase; Region: DEDD_Tnp_IS110; pfam01548
395963007962	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
395963007963	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
395963007964	benzoate transport; Region: 2A0115; TIGR00895
395963007965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963007966	putative substrate translocation pore; other site
395963007967	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395963007968	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
395963007969	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
395963007970	Putative cyclase; Region: Cyclase; cl00814
395963007971	Putative cyclase; Region: Cyclase; cl00814
395963007972	Helix-turn-helix domain; Region: HTH_17; pfam12728
395963007973	Citrate synthase; Region: Citrate_synt; pfam00285
395963007974	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
395963007975	dimer interface [polypeptide binding]; other site
395963007976	active site
395963007977	oxalacetate/citrate binding site [chemical binding]; other site
395963007978	citrylCoA binding site [chemical binding]; other site
395963007979	coenzyme A binding site [chemical binding]; other site
395963007980	catalytic triad [active]
395963007981	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
395963007982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
395963007983	short chain dehydrogenase; Provisional; Region: PRK09072
395963007984	classical (c) SDRs; Region: SDR_c; cd05233
395963007985	NAD(P) binding site [chemical binding]; other site
395963007986	active site
395963007987	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
395963007988	heme binding pocket [chemical binding]; other site
395963007989	heme ligand [chemical binding]; other site
395963007990	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395963007991	AMP-binding enzyme; Region: AMP-binding; pfam00501
395963007992	acyl-activating enzyme (AAE) consensus motif; other site
395963007993	AMP binding site [chemical binding]; other site
395963007994	active site
395963007995	CoA binding site [chemical binding]; other site
395963007996	Thermostable hemolysin; Region: T_hemolysin; pfam12261
395963007997	osmolarity response regulator; Provisional; Region: ompR; PRK09468
395963007998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963007999	active site
395963008000	phosphorylation site [posttranslational modification]
395963008001	intermolecular recognition site; other site
395963008002	dimerization interface [polypeptide binding]; other site
395963008003	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963008004	DNA binding site [nucleotide binding]
395963008005	HAMP domain; Region: HAMP; pfam00672
395963008006	dimerization interface [polypeptide binding]; other site
395963008007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963008008	dimer interface [polypeptide binding]; other site
395963008009	phosphorylation site [posttranslational modification]
395963008010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963008011	ATP binding site [chemical binding]; other site
395963008012	Mg2+ binding site [ion binding]; other site
395963008013	G-X-G motif; other site
395963008014	VacJ like lipoprotein; Region: VacJ; cl01073
395963008015	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395963008016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963008017	TPR motif; other site
395963008018	binding surface
395963008019	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395963008020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963008021	S-adenosylmethionine binding site [chemical binding]; other site
395963008022	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
395963008023	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
395963008024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963008025	TPR motif; other site
395963008026	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395963008027	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963008028	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
395963008029	inhibitor-cofactor binding pocket; inhibition site
395963008030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963008031	catalytic residue [active]
395963008032	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
395963008033	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
395963008034	malonyl-CoA binding site [chemical binding]; other site
395963008035	dimer interface [polypeptide binding]; other site
395963008036	active site
395963008037	product binding site; other site
395963008038	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395963008039	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395963008040	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963008041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963008042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963008043	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
395963008044	catalytic core [active]
395963008045	Cupin; Region: Cupin_6; pfam12852
395963008046	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963008047	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963008048	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963008049	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
395963008050	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395963008051	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963008052	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963008053	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963008054	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963008055	active site
395963008056	catalytic tetrad [active]
395963008057	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
395963008058	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963008059	putative NAD(P) binding site [chemical binding]; other site
395963008060	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
395963008061	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963008062	putative NAD(P) binding site [chemical binding]; other site
395963008063	Predicted acyl esterases [General function prediction only]; Region: COG2936
395963008064	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
395963008065	Winged helix-turn helix; Region: HTH_29; pfam13551
395963008066	Winged helix-turn helix; Region: HTH_33; pfam13592
395963008067	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395963008068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395963008069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963008070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963008071	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
395963008072	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395963008073	phosphate binding site [ion binding]; other site
395963008074	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
395963008075	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
395963008076	proposed catalytic triad [active]
395963008077	conserved cys residue [active]
395963008078	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395963008079	active site
395963008080	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395963008081	dimer interface [polypeptide binding]; other site
395963008082	non-prolyl cis peptide bond; other site
395963008083	insertion regions; other site
395963008084	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
395963008085	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395963008086	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395963008087	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
395963008088	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395963008089	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395963008090	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395963008091	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395963008092	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395963008093	putative NAD(P) binding site [chemical binding]; other site
395963008094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963008095	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963008096	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008098	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
395963008099	putative substrate binding pocket [chemical binding]; other site
395963008100	putative dimerization interface [polypeptide binding]; other site
395963008101	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
395963008102	active site
395963008103	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
395963008104	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395963008105	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395963008106	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
395963008107	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
395963008108	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
395963008109	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395963008110	TOBE domain; Region: TOBE; cl01440
395963008111	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
395963008112	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
395963008113	Substrate binding site; other site
395963008114	Cupin domain; Region: Cupin_2; cl17218
395963008115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963008116	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963008117	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
395963008118	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395963008119	Chain length determinant protein; Region: Wzz; pfam02706
395963008120	Chain length determinant protein; Region: Wzz; cl15801
395963008121	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
395963008122	Nucleotide binding site [chemical binding]; other site
395963008123	P loop; other site
395963008124	DTAP/Switch II; other site
395963008125	Switch I; other site
395963008126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963008127	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963008128	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
395963008129	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
395963008130	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963008131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963008132	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963008133	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395963008134	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395963008135	Acyltransferase family; Region: Acyl_transf_3; pfam01757
395963008136	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
395963008137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008138	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963008139	NAD(P) binding site [chemical binding]; other site
395963008140	active site
395963008141	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
395963008142	Int/Topo IB signature motif; other site
395963008143	YcfA-like protein; Region: YcfA; pfam07927
395963008144	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
395963008145	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
395963008146	Helix-turn-helix domain; Region: HTH_17; cl17695
395963008147	AAA domain; Region: AAA_25; pfam13481
395963008148	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963008149	Walker A motif; other site
395963008150	ATP binding site [chemical binding]; other site
395963008151	Walker B motif; other site
395963008152	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
395963008153	HsdM N-terminal domain; Region: HsdM_N; pfam12161
395963008154	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395963008155	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395963008156	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395963008157	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395963008158	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
395963008159	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
395963008160	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963008161	ATP binding site [chemical binding]; other site
395963008162	putative Mg++ binding site [ion binding]; other site
395963008163	Protein of unknown function DUF45; Region: DUF45; pfam01863
395963008164	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
395963008165	active site
395963008166	catalytic triad [active]
395963008167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963008168	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395963008169	Walker A motif; other site
395963008170	ATP binding site [chemical binding]; other site
395963008171	Walker B motif; other site
395963008172	arginine finger; other site
395963008173	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395963008174	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395963008175	metal-binding site [ion binding]
395963008176	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395963008177	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395963008178	metal-binding site [ion binding]
395963008179	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963008180	Serine hydrolase; Region: Ser_hydrolase; pfam06821
395963008181	adenylosuccinate lyase; Provisional; Region: PRK07492
395963008182	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
395963008183	tetramer interface [polypeptide binding]; other site
395963008184	active site
395963008185	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
395963008186	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
395963008187	putative active site pocket [active]
395963008188	cleavage site
395963008189	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395963008190	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963008191	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963008192	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
395963008193	chemotaxis protein; Reviewed; Region: PRK12798
395963008194	flagellar motor protein MotB; Validated; Region: motB; PRK05996
395963008195	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
395963008196	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395963008197	ligand binding site [chemical binding]; other site
395963008198	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
395963008199	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
395963008200	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
395963008201	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395963008202	flagellin; Reviewed; Region: PRK12687
395963008203	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395963008204	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395963008205	active site residue [active]
395963008206	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
395963008207	active site residue [active]
395963008208	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
395963008209	active site residue [active]
395963008210	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395963008211	active site
395963008212	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
395963008213	dimer interface [polypeptide binding]; other site
395963008214	non-prolyl cis peptide bond; other site
395963008215	insertion regions; other site
395963008216	hypothetical protein; Provisional; Region: PRK06208
395963008217	intersubunit interface [polypeptide binding]; other site
395963008218	active site
395963008219	Zn2+ binding site [ion binding]; other site
395963008220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
395963008221	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963008222	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963008223	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963008224	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963008225	nucleophile elbow; other site
395963008226	Patatin phospholipase; Region: DUF3734; pfam12536
395963008227	acetoacetate decarboxylase; Provisional; Region: PRK02265
395963008228	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008229	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
395963008230	NAD(P) binding site [chemical binding]; other site
395963008231	active site
395963008232	cobalamin synthase; Reviewed; Region: cobS; PRK00235
395963008233	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
395963008234	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395963008235	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395963008236	Peptidase family M23; Region: Peptidase_M23; pfam01551
395963008237	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
395963008238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963008239	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
395963008240	seryl-tRNA synthetase; Provisional; Region: PRK05431
395963008241	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
395963008242	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
395963008243	dimer interface [polypeptide binding]; other site
395963008244	active site
395963008245	motif 1; other site
395963008246	motif 2; other site
395963008247	motif 3; other site
395963008248	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
395963008249	sec-independent translocase; Provisional; Region: PRK00708
395963008250	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
395963008251	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
395963008252	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
395963008253	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
395963008254	Sporulation related domain; Region: SPOR; pfam05036
395963008255	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
395963008256	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
395963008257	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
395963008258	active site
395963008259	HIGH motif; other site
395963008260	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395963008261	KMSK motif region; other site
395963008262	tRNA binding surface [nucleotide binding]; other site
395963008263	DALR anticodon binding domain; Region: DALR_1; smart00836
395963008264	anticodon binding site; other site
395963008265	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
395963008266	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
395963008267	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395963008268	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
395963008269	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
395963008270	Protein required for attachment to host cells; Region: Host_attach; pfam10116
395963008271	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
395963008272	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
395963008273	hinge; other site
395963008274	active site
395963008275	major tropism determinant; Region: mtd; PHA00653
395963008276	Putative phage tail protein; Region: Phage-tail_3; pfam13550
395963008277	NlpC/P60 family; Region: NLPC_P60; cl17555
395963008278	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
395963008279	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
395963008280	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
395963008281	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
395963008282	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
395963008283	Protein of unknown function (DUF763); Region: DUF763; pfam05559
395963008284	Uncharacterized conserved protein [Function unknown]; Region: COG2835
395963008285	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
395963008286	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
395963008287	active site
395963008288	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
395963008289	catalytic triad [active]
395963008290	dimer interface [polypeptide binding]; other site
395963008291	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395963008292	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395963008293	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
395963008294	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
395963008295	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
395963008296	active site
395963008297	dimer interface [polypeptide binding]; other site
395963008298	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
395963008299	dimer interface [polypeptide binding]; other site
395963008300	active site
395963008301	Suppression of tumorigenicity 7; Region: ST7; cd11557
395963008302	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
395963008303	dimerization domain swap beta strand [polypeptide binding]; other site
395963008304	regulatory protein interface [polypeptide binding]; other site
395963008305	active site
395963008306	regulatory phosphorylation site [posttranslational modification]; other site
395963008307	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
395963008308	active pocket/dimerization site; other site
395963008309	active site
395963008310	phosphorylation site [posttranslational modification]
395963008311	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
395963008312	Hpr binding site; other site
395963008313	active site
395963008314	homohexamer subunit interaction site [polypeptide binding]; other site
395963008315	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
395963008316	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
395963008317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963008318	HAMP domain; Region: HAMP; pfam00672
395963008319	dimerization interface [polypeptide binding]; other site
395963008320	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963008321	dimer interface [polypeptide binding]; other site
395963008322	phosphorylation site [posttranslational modification]
395963008323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963008324	ATP binding site [chemical binding]; other site
395963008325	Mg2+ binding site [ion binding]; other site
395963008326	G-X-G motif; other site
395963008327	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963008328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963008329	active site
395963008330	phosphorylation site [posttranslational modification]
395963008331	intermolecular recognition site; other site
395963008332	dimerization interface [polypeptide binding]; other site
395963008333	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963008334	DNA binding site [nucleotide binding]
395963008335	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
395963008336	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
395963008337	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
395963008338	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
395963008339	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395963008340	transmembrane helices; other site
395963008341	5'-3' exonuclease; Region: 53EXOc; smart00475
395963008342	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
395963008343	active site
395963008344	metal binding site 1 [ion binding]; metal-binding site
395963008345	putative 5' ssDNA interaction site; other site
395963008346	metal binding site 3; metal-binding site
395963008347	metal binding site 2 [ion binding]; metal-binding site
395963008348	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
395963008349	putative DNA binding site [nucleotide binding]; other site
395963008350	putative metal binding site [ion binding]; other site
395963008351	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
395963008352	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
395963008353	active site
395963008354	catalytic site [active]
395963008355	substrate binding site [chemical binding]; other site
395963008356	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
395963008357	active site
395963008358	DNA binding site [nucleotide binding]
395963008359	catalytic site [active]
395963008360	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
395963008361	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395963008362	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963008363	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963008364	catalytic residue [active]
395963008365	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
395963008366	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395963008367	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
395963008368	L-aspartate oxidase; Provisional; Region: PRK06175
395963008369	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395963008370	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
395963008371	putative SdhC subunit interface [polypeptide binding]; other site
395963008372	putative proximal heme binding site [chemical binding]; other site
395963008373	putative Iron-sulfur protein interface [polypeptide binding]; other site
395963008374	putative proximal quinone binding site; other site
395963008375	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
395963008376	Iron-sulfur protein interface; other site
395963008377	proximal quinone binding site [chemical binding]; other site
395963008378	SdhD (CybS) interface [polypeptide binding]; other site
395963008379	proximal heme binding site [chemical binding]; other site
395963008380	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
395963008381	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395963008382	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
395963008383	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
395963008384	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
395963008385	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
395963008386	CARDB; Region: CARDB; pfam07705
395963008387	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395963008388	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395963008389	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
395963008390	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
395963008391	Chain length determinant protein; Region: Wzz; cl15801
395963008392	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395963008393	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963008394	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
395963008395	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395963008396	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963008397	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963008398	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395963008399	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963008400	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
395963008401	DNA binding site [nucleotide binding]
395963008402	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
395963008403	putative ligand binding site [chemical binding]; other site
395963008404	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
395963008405	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
395963008406	putative di-iron ligands [ion binding]; other site
395963008407	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
395963008408	[2Fe-2S] cluster binding site [ion binding]; other site
395963008409	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963008410	active site
395963008411	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963008412	catalytic tetrad [active]
395963008413	Creatinine amidohydrolase; Region: Creatininase; pfam02633
395963008414	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963008415	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395963008416	putative ligand binding site [chemical binding]; other site
395963008417	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395963008418	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
395963008419	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395963008420	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
395963008421	alpha subunit interaction interface [polypeptide binding]; other site
395963008422	Walker A motif; other site
395963008423	ATP binding site [chemical binding]; other site
395963008424	Walker B motif; other site
395963008425	inhibitor binding site; inhibition site
395963008426	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395963008427	F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447
395963008428	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
395963008429	gamma subunit interface [polypeptide binding]; other site
395963008430	epsilon subunit interface [polypeptide binding]; other site
395963008431	LBP interface [polypeptide binding]; other site
395963008432	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
395963008433	F0F1 ATP synthase subunit A; Provisional; Region: PRK13421
395963008434	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
395963008435	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
395963008436	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395963008437	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
395963008438	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
395963008439	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395963008440	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963008441	Walker A motif; other site
395963008442	ATP binding site [chemical binding]; other site
395963008443	Walker B motif; other site
395963008444	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395963008445	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
395963008446	core domain interface [polypeptide binding]; other site
395963008447	delta subunit interface [polypeptide binding]; other site
395963008448	epsilon subunit interface [polypeptide binding]; other site
395963008449	short chain dehydrogenase; Provisional; Region: PRK06500
395963008450	classical (c) SDRs; Region: SDR_c; cd05233
395963008451	NAD(P) binding site [chemical binding]; other site
395963008452	active site
395963008453	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008455	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963008456	putative effector binding pocket; other site
395963008457	dimerization interface [polypeptide binding]; other site
395963008458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008460	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963008461	putative effector binding pocket; other site
395963008462	dimerization interface [polypeptide binding]; other site
395963008463	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395963008464	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395963008465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963008466	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395963008467	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395963008468	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395963008469	Predicted transcriptional regulator [Transcription]; Region: COG1959
395963008470	Transcriptional regulator; Region: Rrf2; pfam02082
395963008471	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
395963008472	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
395963008473	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
395963008474	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395963008475	oligomeric interface; other site
395963008476	putative active site [active]
395963008477	homodimer interface [polypeptide binding]; other site
395963008478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963008479	AAA domain; Region: AAA_22; pfam13401
395963008480	Walker A motif; other site
395963008481	ATP binding site [chemical binding]; other site
395963008482	Walker B motif; other site
395963008483	arginine finger; other site
395963008484	stage V sporulation protein K; Region: spore_V_K; TIGR02881
395963008485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963008486	Walker A motif; other site
395963008487	ATP binding site [chemical binding]; other site
395963008488	Walker B motif; other site
395963008489	arginine finger; other site
395963008490	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395963008491	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963008492	Uncharacterized conserved protein [Function unknown]; Region: COG4544
395963008493	DNA Polymerase Y-family; Region: PolY_like; cd03468
395963008494	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
395963008495	DNA binding site [nucleotide binding]
395963008496	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
395963008497	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
395963008498	putative active site [active]
395963008499	putative PHP Thumb interface [polypeptide binding]; other site
395963008500	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395963008501	generic binding surface I; other site
395963008502	generic binding surface II; other site
395963008503	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
395963008504	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
395963008505	flagellar motor protein MotA; Validated; Region: PRK09110
395963008506	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
395963008507	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
395963008508	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
395963008509	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
395963008510	FliG C-terminal domain; Region: FliG_C; pfam01706
395963008511	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
395963008512	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
395963008513	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395963008514	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395963008515	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
395963008516	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
395963008517	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
395963008518	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963008519	Walker A motif; other site
395963008520	ATP binding site [chemical binding]; other site
395963008521	Walker B motif; other site
395963008522	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
395963008523	Proline dehydrogenase; Region: Pro_dh; pfam01619
395963008524	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
395963008525	Glutamate binding site [chemical binding]; other site
395963008526	NAD binding site [chemical binding]; other site
395963008527	catalytic residues [active]
395963008528	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
395963008529	active site
395963008530	Mn binding site [ion binding]; other site
395963008531	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
395963008532	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963008533	inhibitor-cofactor binding pocket; inhibition site
395963008534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963008535	catalytic residue [active]
395963008536	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395963008537	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395963008538	putative DNA binding site [nucleotide binding]; other site
395963008539	putative Zn2+ binding site [ion binding]; other site
395963008540	AsnC family; Region: AsnC_trans_reg; pfam01037
395963008541	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
395963008542	short chain dehydrogenase; Provisional; Region: PRK12744
395963008543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008544	NAD(P) binding site [chemical binding]; other site
395963008545	active site
395963008546	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008547	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008548	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
395963008549	putative effector binding pocket; other site
395963008550	putative dimerization interface [polypeptide binding]; other site
395963008551	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395963008552	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395963008553	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963008554	motif II; other site
395963008555	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
395963008556	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395963008557	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395963008558	TM-ABC transporter signature motif; other site
395963008559	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395963008560	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395963008561	Walker A/P-loop; other site
395963008562	ATP binding site [chemical binding]; other site
395963008563	Q-loop/lid; other site
395963008564	ABC transporter signature motif; other site
395963008565	Walker B; other site
395963008566	D-loop; other site
395963008567	H-loop/switch region; other site
395963008568	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395963008569	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
395963008570	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395963008571	putative ligand binding site [chemical binding]; other site
395963008572	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963008573	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963008574	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395963008575	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395963008576	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
395963008577	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963008578	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963008579	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395963008580	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963008581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963008582	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
395963008583	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395963008584	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395963008585	ligand binding site [chemical binding]; other site
395963008586	NAD binding site [chemical binding]; other site
395963008587	dimerization interface [polypeptide binding]; other site
395963008588	catalytic site [active]
395963008589	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
395963008590	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395963008591	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395963008592	tetramerization interface [polypeptide binding]; other site
395963008593	NAD(P) binding site [chemical binding]; other site
395963008594	catalytic residues [active]
395963008595	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395963008596	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
395963008597	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
395963008598	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
395963008599	putative active site [active]
395963008600	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
395963008601	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395963008602	dimer interface [polypeptide binding]; other site
395963008603	PYR/PP interface [polypeptide binding]; other site
395963008604	TPP binding site [chemical binding]; other site
395963008605	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395963008606	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395963008607	TPP-binding site [chemical binding]; other site
395963008608	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
395963008609	short chain dehydrogenase; Provisional; Region: PRK06198
395963008610	classical (c) SDRs; Region: SDR_c; cd05233
395963008611	NAD(P) binding site [chemical binding]; other site
395963008612	active site
395963008613	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
395963008614	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395963008615	putative ligand binding site [chemical binding]; other site
395963008616	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395963008617	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
395963008618	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
395963008619	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
395963008620	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
395963008621	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395963008622	Protein of unknown function DUF58; Region: DUF58; pfam01882
395963008623	MoxR-like ATPases [General function prediction only]; Region: COG0714
395963008624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395963008625	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
395963008626	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
395963008627	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
395963008628	active site
395963008629	NTP binding site [chemical binding]; other site
395963008630	metal binding triad [ion binding]; metal-binding site
395963008631	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
395963008632	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
395963008633	Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474
395963008634	[2Fe-2S] cluster binding site [ion binding]; other site
395963008635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963008636	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395963008637	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
395963008638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963008639	Protein of unknown function (DUF779); Region: DUF779; pfam05610
395963008640	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
395963008641	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395963008642	NAD(P) binding site [chemical binding]; other site
395963008643	catalytic residues [active]
395963008644	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
395963008645	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
395963008646	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395963008647	Gram-negative bacterial tonB protein; Region: TonB; cl10048
395963008648	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
395963008649	active site
395963008650	catalytic residues [active]
395963008651	pyruvate kinase; Provisional; Region: PRK06247
395963008652	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395963008653	domain interfaces; other site
395963008654	active site
395963008655	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
395963008656	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395963008657	tetrameric interface [polypeptide binding]; other site
395963008658	activator binding site; other site
395963008659	NADP binding site [chemical binding]; other site
395963008660	substrate binding site [chemical binding]; other site
395963008661	catalytic residues [active]
395963008662	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395963008663	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
395963008664	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
395963008665	putative ligand binding site [chemical binding]; other site
395963008666	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395963008667	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395963008668	TM-ABC transporter signature motif; other site
395963008669	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395963008670	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395963008671	Walker A/P-loop; other site
395963008672	ATP binding site [chemical binding]; other site
395963008673	Q-loop/lid; other site
395963008674	ABC transporter signature motif; other site
395963008675	Walker B; other site
395963008676	D-loop; other site
395963008677	H-loop/switch region; other site
395963008678	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395963008679	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395963008680	DNA binding site [nucleotide binding]
395963008681	sequence specific DNA binding site [nucleotide binding]; other site
395963008682	putative cAMP binding site [chemical binding]; other site
395963008683	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395963008684	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
395963008685	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
395963008686	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395963008687	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
395963008688	putative substrate binding site [chemical binding]; other site
395963008689	putative ATP binding site [chemical binding]; other site
395963008690	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
395963008691	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395963008692	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395963008693	phosphogluconate dehydratase; Validated; Region: PRK09054
395963008694	6-phosphogluconate dehydratase; Region: edd; TIGR01196
395963008695	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
395963008696	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395963008697	active site
395963008698	intersubunit interface [polypeptide binding]; other site
395963008699	catalytic residue [active]
395963008700	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
395963008701	heme-binding site [chemical binding]; other site
395963008702	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
395963008703	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395963008704	active site
395963008705	intersubunit interface [polypeptide binding]; other site
395963008706	catalytic residue [active]
395963008707	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
395963008708	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
395963008709	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395963008710	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
395963008711	Bacterial transcriptional regulator; Region: IclR; pfam01614
395963008712	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
395963008713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963008714	putative substrate translocation pore; other site
395963008715	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
395963008716	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
395963008717	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
395963008718	substrate binding site [chemical binding]; other site
395963008719	ATP binding site [chemical binding]; other site
395963008720	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963008721	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
395963008722	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963008723	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395963008724	YGGT family; Region: YGGT; pfam02325
395963008725	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963008726	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963008727	Transposase; Region: HTH_Tnp_1; pfam01527
395963008728	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
395963008729	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
395963008730	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
395963008731	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
395963008732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008733	NAD(P) binding site [chemical binding]; other site
395963008734	active site
395963008735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963008736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963008737	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
395963008738	GMP synthase; Reviewed; Region: guaA; PRK00074
395963008739	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
395963008740	AMP/PPi binding site [chemical binding]; other site
395963008741	candidate oxyanion hole; other site
395963008742	catalytic triad [active]
395963008743	potential glutamine specificity residues [chemical binding]; other site
395963008744	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
395963008745	ATP Binding subdomain [chemical binding]; other site
395963008746	Ligand Binding sites [chemical binding]; other site
395963008747	Dimerization subdomain; other site
395963008748	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395963008749	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
395963008750	active site
395963008751	hypothetical protein; Reviewed; Region: PRK00024
395963008752	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
395963008753	MPN+ (JAMM) motif; other site
395963008754	Zinc-binding site [ion binding]; other site
395963008755	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395963008756	Usg-like family; Region: Usg; pfam06233
395963008757	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
395963008758	Ligand binding site; other site
395963008759	metal-binding site
395963008760	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
395963008761	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395963008762	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395963008763	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
395963008764	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395963008765	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395963008766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008767	short chain dehydrogenase; Provisional; Region: PRK09134
395963008768	NAD(P) binding site [chemical binding]; other site
395963008769	active site
395963008770	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
395963008771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963008772	S-adenosylmethionine binding site [chemical binding]; other site
395963008773	ABC1 family; Region: ABC1; cl17513
395963008774	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
395963008775	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
395963008776	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
395963008777	Flavoprotein; Region: Flavoprotein; pfam02441
395963008778	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
395963008779	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
395963008780	trimer interface [polypeptide binding]; other site
395963008781	active site
395963008782	Predicted transcriptional regulator [Transcription]; Region: COG1959
395963008783	Transcriptional regulator; Region: Rrf2; pfam02082
395963008784	Transcriptional regulator; Region: Rrf2; cl17282
395963008785	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
395963008786	active site
395963008787	phosphorylation site [posttranslational modification]
395963008788	Glucokinase; Region: Glucokinase; pfam02685
395963008789	glucokinase, proteobacterial type; Region: glk; TIGR00749
395963008790	fumarate hydratase; Provisional; Region: PRK15389
395963008791	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
395963008792	Fumarase C-terminus; Region: Fumerase_C; pfam05683
395963008793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
395963008794	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
395963008795	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
395963008796	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395963008797	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395963008798	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395963008799	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395963008800	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395963008801	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963008802	catalytic loop [active]
395963008803	iron binding site [ion binding]; other site
395963008804	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395963008805	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395963008806	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
395963008807	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963008808	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963008809	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
395963008810	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
395963008811	Protein export membrane protein; Region: SecD_SecF; cl14618
395963008812	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
395963008813	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
395963008814	active site
395963008815	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
395963008816	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395963008817	IHF dimer interface [polypeptide binding]; other site
395963008818	IHF - DNA interface [nucleotide binding]; other site
395963008819	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
395963008820	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
395963008821	tandem repeat interface [polypeptide binding]; other site
395963008822	oligomer interface [polypeptide binding]; other site
395963008823	active site residues [active]
395963008824	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
395963008825	putative active site [active]
395963008826	Ap4A binding site [chemical binding]; other site
395963008827	nudix motif; other site
395963008828	putative metal binding site [ion binding]; other site
395963008829	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
395963008830	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395963008831	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395963008832	protein binding site [polypeptide binding]; other site
395963008833	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395963008834	Catalytic dyad [active]
395963008835	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
395963008836	Peptidase family M23; Region: Peptidase_M23; pfam01551
395963008837	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
395963008838	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
395963008839	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
395963008840	nucleotide binding site [chemical binding]; other site
395963008841	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395963008842	SBD interface [polypeptide binding]; other site
395963008843	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
395963008844	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
395963008845	RNA binding site [nucleotide binding]; other site
395963008846	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
395963008847	RNA binding site [nucleotide binding]; other site
395963008848	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
395963008849	RNA binding site [nucleotide binding]; other site
395963008850	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395963008851	RNA binding site [nucleotide binding]; other site
395963008852	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
395963008853	RNA binding site [nucleotide binding]; other site
395963008854	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
395963008855	RNA binding site [nucleotide binding]; other site
395963008856	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395963008857	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395963008858	cytidylate kinase; Provisional; Region: cmk; PRK00023
395963008859	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
395963008860	CMP-binding site; other site
395963008861	The sites determining sugar specificity; other site
395963008862	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
395963008863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
395963008864	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
395963008865	Helix-turn-helix domain; Region: HTH_18; pfam12833
395963008866	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial  homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613
395963008867	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395963008868	putative active site [active]
395963008869	catalytic site [active]
395963008870	putative metal binding site [ion binding]; other site
395963008871	Predicted transcriptional regulator [Transcription]; Region: COG2378
395963008872	HTH domain; Region: HTH_11; pfam08279
395963008873	WYL domain; Region: WYL; pfam13280
395963008874	Cupin domain; Region: Cupin_2; cl17218
395963008875	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
395963008876	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395963008877	active site
395963008878	DNA binding site [nucleotide binding]
395963008879	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395963008880	putative hydrophobic ligand binding site [chemical binding]; other site
395963008881	protein interface [polypeptide binding]; other site
395963008882	gate; other site
395963008883	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
395963008884	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395963008885	MarR family; Region: MarR; pfam01047
395963008886	Isochorismatase family; Region: Isochorismatase; pfam00857
395963008887	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395963008888	catalytic triad [active]
395963008889	conserved cis-peptide bond; other site
395963008890	H+ Antiporter protein; Region: 2A0121; TIGR00900
395963008891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963008892	putative substrate translocation pore; other site
395963008893	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963008894	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963008895	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963008896	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395963008897	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395963008898	conserved cys residue [active]
395963008899	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
395963008900	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008901	NAD(P) binding site [chemical binding]; other site
395963008902	active site
395963008903	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395963008904	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395963008905	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
395963008906	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
395963008907	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395963008908	putative NAD(P) binding site [chemical binding]; other site
395963008909	substrate binding site [chemical binding]; other site
395963008910	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008912	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963008913	dimerization interface [polypeptide binding]; other site
395963008914	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963008915	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963008916	active site
395963008917	catalytic tetrad [active]
395963008918	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395963008919	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
395963008920	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008921	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395963008922	dimerization interface [polypeptide binding]; other site
395963008923	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
395963008924	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
395963008925	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
395963008926	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
395963008927	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963008928	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963008929	N-terminal plug; other site
395963008930	ligand-binding site [chemical binding]; other site
395963008931	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395963008932	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
395963008933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
395963008934	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
395963008935	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395963008936	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963008937	DNA binding residues [nucleotide binding]
395963008938	dimerization interface [polypeptide binding]; other site
395963008939	Autoinducer synthetase; Region: Autoind_synth; cl17404
395963008940	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
395963008941	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395963008942	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963008943	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963008944	DNA binding residues [nucleotide binding]
395963008945	dimerization interface [polypeptide binding]; other site
395963008946	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
395963008947	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
395963008948	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963008949	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963008950	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963008951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963008952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963008953	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
395963008954	dimerization interface [polypeptide binding]; other site
395963008955	substrate binding pocket [chemical binding]; other site
395963008956	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963008957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963008958	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
395963008959	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395963008960	dimerization interface [polypeptide binding]; other site
395963008961	metal binding site [ion binding]; metal-binding site
395963008962	Isochorismatase family; Region: Isochorismatase; pfam00857
395963008963	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395963008964	catalytic triad [active]
395963008965	conserved cis-peptide bond; other site
395963008966	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
395963008967	dimer interface [polypeptide binding]; other site
395963008968	substrate binding site [chemical binding]; other site
395963008969	metal binding sites [ion binding]; metal-binding site
395963008970	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395963008971	short chain dehydrogenase; Provisional; Region: PRK07109
395963008972	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
395963008973	putative NAD(P) binding site [chemical binding]; other site
395963008974	active site
395963008975	short chain dehydrogenase; Provisional; Region: PRK06701
395963008976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963008977	NAD(P) binding site [chemical binding]; other site
395963008978	active site
395963008979	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
395963008980	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
395963008981	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395963008982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963008983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963008984	dimer interface [polypeptide binding]; other site
395963008985	phosphorylation site [posttranslational modification]
395963008986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963008987	ATP binding site [chemical binding]; other site
395963008988	Mg2+ binding site [ion binding]; other site
395963008989	G-X-G motif; other site
395963008990	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395963008991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963008992	active site
395963008993	phosphorylation site [posttranslational modification]
395963008994	intermolecular recognition site; other site
395963008995	dimerization interface [polypeptide binding]; other site
395963008996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963008997	Walker A motif; other site
395963008998	ATP binding site [chemical binding]; other site
395963008999	Walker B motif; other site
395963009000	arginine finger; other site
395963009001	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963009002	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
395963009003	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
395963009004	transmembrane helices; other site
395963009005	Protein of unknown function, DUF606; Region: DUF606; pfam04657
395963009006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963009007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
395963009008	Helix-turn-helix domain; Region: HTH_28; pfam13518
395963009009	Homeodomain-like domain; Region: HTH_32; pfam13565
395963009010	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395963009011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395963009012	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395963009013	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395963009014	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395963009015	active site
395963009016	nucleophile elbow; other site
395963009017	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
395963009018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963009019	NAD(P) binding site [chemical binding]; other site
395963009020	active site
395963009021	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
395963009022	metal binding site 2 [ion binding]; metal-binding site
395963009023	putative DNA binding helix; other site
395963009024	metal binding site 1 [ion binding]; metal-binding site
395963009025	dimer interface [polypeptide binding]; other site
395963009026	structural Zn2+ binding site [ion binding]; other site
395963009027	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395963009028	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
395963009029	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395963009030	catalytic residue [active]
395963009031	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
395963009032	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
395963009033	active site
395963009034	homotetramer interface [polypeptide binding]; other site
395963009035	trehalose synthase; Region: treS_nterm; TIGR02456
395963009036	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
395963009037	active site
395963009038	catalytic site [active]
395963009039	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
395963009040	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
395963009041	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
395963009042	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963009043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963009044	dimer interface [polypeptide binding]; other site
395963009045	phosphorylation site [posttranslational modification]
395963009046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963009047	ATP binding site [chemical binding]; other site
395963009048	Mg2+ binding site [ion binding]; other site
395963009049	G-X-G motif; other site
395963009050	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963009051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963009052	active site
395963009053	phosphorylation site [posttranslational modification]
395963009054	intermolecular recognition site; other site
395963009055	dimerization interface [polypeptide binding]; other site
395963009056	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395963009057	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395963009058	dimer interface [polypeptide binding]; other site
395963009059	active site
395963009060	CoA binding pocket [chemical binding]; other site
395963009061	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395963009062	Ligand Binding Site [chemical binding]; other site
395963009063	PRC-barrel domain; Region: PRC; pfam05239
395963009064	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395963009065	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395963009066	putative dimer interface [polypeptide binding]; other site
395963009067	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
395963009068	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
395963009069	Protein of unknown function (DUF983); Region: DUF983; cl02211
395963009070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963009071	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395963009072	putative substrate translocation pore; other site
395963009073	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
395963009074	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
395963009075	Recombination protein O N terminal; Region: RecO_N; pfam11967
395963009076	Recombination protein O C terminal; Region: RecO_C; pfam02565
395963009077	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
395963009078	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395963009079	NADP binding site [chemical binding]; other site
395963009080	dimer interface [polypeptide binding]; other site
395963009081	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
395963009082	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
395963009083	tetramer interface [polypeptide binding]; other site
395963009084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963009085	catalytic residue [active]
395963009086	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
395963009087	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
395963009088	active site
395963009089	dimer interface [polypeptide binding]; other site
395963009090	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
395963009091	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395963009092	active site
395963009093	FMN binding site [chemical binding]; other site
395963009094	substrate binding site [chemical binding]; other site
395963009095	3Fe-4S cluster binding site [ion binding]; other site
395963009096	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
395963009097	domain interface; other site
395963009098	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
395963009099	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963009100	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
395963009101	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
395963009102	Probable Catalytic site; other site
395963009103	metal-binding site
395963009104	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963009105	DNA-binding site [nucleotide binding]; DNA binding site
395963009106	RNA-binding motif; other site
395963009107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963009108	S-adenosylmethionine binding site [chemical binding]; other site
395963009109	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
395963009110	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
395963009111	Ligand Binding Site [chemical binding]; other site
395963009112	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
395963009113	Predicted integral membrane protein [Function unknown]; Region: COG0392
395963009114	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395963009115	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
395963009116	interface (dimer of trimers) [polypeptide binding]; other site
395963009117	Substrate-binding/catalytic site; other site
395963009118	Zn-binding sites [ion binding]; other site
395963009119	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
395963009120	NlpC/P60 family; Region: NLPC_P60; cl17555
395963009121	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
395963009122	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
395963009123	23S rRNA binding site [nucleotide binding]; other site
395963009124	L21 binding site [polypeptide binding]; other site
395963009125	L13 binding site [polypeptide binding]; other site
395963009126	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395963009127	AAA domain; Region: AAA_33; pfam13671
395963009128	ATP-binding site [chemical binding]; other site
395963009129	Gluconate-6-phosphate binding site [chemical binding]; other site
395963009130	Transglycosylase; Region: Transgly; pfam00912
395963009131	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395963009132	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395963009133	DNA polymerase III subunit beta; Validated; Region: PRK05643
395963009134	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
395963009135	putative DNA binding surface [nucleotide binding]; other site
395963009136	dimer interface [polypeptide binding]; other site
395963009137	beta-clamp/clamp loader binding surface; other site
395963009138	beta-clamp/translesion DNA polymerase binding surface; other site
395963009139	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395963009140	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
395963009141	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395963009142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963009143	S-adenosylmethionine binding site [chemical binding]; other site
395963009144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395963009145	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395963009146	Uncharacterized conserved protein [Function unknown]; Region: COG2308
395963009147	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
395963009148	Fasciclin domain; Region: Fasciclin; pfam02469
395963009149	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
395963009150	active site
395963009151	oxyanion hole [active]
395963009152	catalytic triad [active]
395963009153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395963009154	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395963009155	Predicted membrane protein [Function unknown]; Region: COG2259
395963009156	putative acyltransferase; Provisional; Region: PRK05790
395963009157	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395963009158	dimer interface [polypeptide binding]; other site
395963009159	active site
395963009160	haemagglutination activity domain; Region: Haemagg_act; pfam05860
395963009161	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
395963009162	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
395963009163	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
395963009164	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
395963009165	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395963009166	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
395963009167	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395963009168	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395963009169	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
395963009170	TPR repeat; Region: TPR_11; pfam13414
395963009171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009172	binding surface
395963009173	TPR motif; other site
395963009174	TPR repeat; Region: TPR_11; pfam13414
395963009175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009176	binding surface
395963009177	TPR motif; other site
395963009178	TPR repeat; Region: TPR_11; pfam13414
395963009179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009180	binding surface
395963009181	TPR motif; other site
395963009182	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
395963009183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009184	TPR motif; other site
395963009185	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963009186	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395963009187	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395963009188	type II secretion system protein D; Region: type_II_gspD; TIGR02517
395963009189	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395963009190	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
395963009191	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395963009192	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
395963009193	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
395963009194	putative ligand binding site [chemical binding]; other site
395963009195	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395963009196	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395963009197	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
395963009198	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395963009199	TM-ABC transporter signature motif; other site
395963009200	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
395963009201	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
395963009202	Walker A/P-loop; other site
395963009203	ATP binding site [chemical binding]; other site
395963009204	Q-loop/lid; other site
395963009205	ABC transporter signature motif; other site
395963009206	Walker B; other site
395963009207	D-loop; other site
395963009208	H-loop/switch region; other site
395963009209	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
395963009210	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
395963009211	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
395963009212	putative ligand binding site [chemical binding]; other site
395963009213	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
395963009214	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
395963009215	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
395963009216	active site
395963009217	catalytic residues [active]
395963009218	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
395963009219	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395963009220	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
395963009221	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
395963009222	dimer interface [polypeptide binding]; other site
395963009223	NADP binding site [chemical binding]; other site
395963009224	catalytic residues [active]
395963009225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963009226	D-galactonate transporter; Region: 2A0114; TIGR00893
395963009227	putative substrate translocation pore; other site
395963009228	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395963009229	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
395963009230	inhibitor site; inhibition site
395963009231	active site
395963009232	dimer interface [polypeptide binding]; other site
395963009233	catalytic residue [active]
395963009234	dihydroxy-acid dehydratase; Validated; Region: PRK06131
395963009235	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395963009236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963009237	DNA-binding site [nucleotide binding]; DNA binding site
395963009238	FCD domain; Region: FCD; pfam07729
395963009239	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
395963009240	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395963009241	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
395963009242	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395963009243	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
395963009244	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
395963009245	substrate binding pocket [chemical binding]; other site
395963009246	active site
395963009247	iron coordination sites [ion binding]; other site
395963009248	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395963009249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963009250	membrane-bound complex binding site; other site
395963009251	hinge residues; other site
395963009252	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963009253	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395963009254	N-terminal plug; other site
395963009255	ligand-binding site [chemical binding]; other site
395963009256	Protein of unknown function (DUF938); Region: DUF938; pfam06080
395963009257	PAS domain; Region: PAS; smart00091
395963009258	PAS fold; Region: PAS_4; pfam08448
395963009259	PAS domain; Region: PAS_9; pfam13426
395963009260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395963009261	HWE histidine kinase; Region: HWE_HK; pfam07536
395963009262	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395963009263	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395963009264	HlyD family secretion protein; Region: HlyD_3; pfam13437
395963009265	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395963009266	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395963009267	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963009268	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963009269	catalytic residue [active]
395963009270	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395963009271	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963009272	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395963009273	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395963009274	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
395963009275	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395963009276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963009277	Walker A motif; other site
395963009278	ATP binding site [chemical binding]; other site
395963009279	Walker B motif; other site
395963009280	arginine finger; other site
395963009281	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963009282	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395963009283	DNA-binding site [nucleotide binding]; DNA binding site
395963009284	RNA-binding motif; other site
395963009285	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
395963009286	active site
395963009287	catalytic motif [active]
395963009288	Zn binding site [ion binding]; other site
395963009289	General stress protein [General function prediction only]; Region: GsiB; COG3729
395963009290	General stress protein [General function prediction only]; Region: GsiB; COG3729
395963009291	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
395963009292	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395963009293	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395963009294	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395963009295	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395963009296	active site
395963009297	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
395963009298	Phosphoesterase family; Region: Phosphoesterase; pfam04185
395963009299	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963009300	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963009301	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
395963009302	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395963009303	minor groove reading motif; other site
395963009304	helix-hairpin-helix signature motif; other site
395963009305	substrate binding pocket [chemical binding]; other site
395963009306	active site
395963009307	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
395963009308	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
395963009309	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
395963009310	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
395963009311	active site
395963009312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395963009313	dimer interface [polypeptide binding]; other site
395963009314	substrate binding site [chemical binding]; other site
395963009315	catalytic residues [active]
395963009316	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
395963009317	Tim44-like domain; Region: Tim44; pfam04280
395963009318	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
395963009319	MltA specific insert domain; Region: MltA; smart00925
395963009320	3D domain; Region: 3D; pfam06725
395963009321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
395963009322	Smr domain; Region: Smr; pfam01713
395963009323	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963009324	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963009325	non-specific DNA binding site [nucleotide binding]; other site
395963009326	salt bridge; other site
395963009327	sequence-specific DNA binding site [nucleotide binding]; other site
395963009328	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
395963009329	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395963009330	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395963009331	structural tetrad; other site
395963009332	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
395963009333	putative GSH binding site [chemical binding]; other site
395963009334	catalytic residues [active]
395963009335	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395963009336	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
395963009337	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
395963009338	dimerization interface [polypeptide binding]; other site
395963009339	ATP binding site [chemical binding]; other site
395963009340	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
395963009341	dimerization interface [polypeptide binding]; other site
395963009342	ATP binding site [chemical binding]; other site
395963009343	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
395963009344	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
395963009345	putative active site [active]
395963009346	catalytic triad [active]
395963009347	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
395963009348	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
395963009349	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
395963009350	ATP binding site [chemical binding]; other site
395963009351	active site
395963009352	substrate binding site [chemical binding]; other site
395963009353	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
395963009354	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
395963009355	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395963009356	active site
395963009357	DNA binding site [nucleotide binding]
395963009358	Int/Topo IB signature motif; other site
395963009359	GTP-binding protein LepA; Provisional; Region: PRK05433
395963009360	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
395963009361	G1 box; other site
395963009362	putative GEF interaction site [polypeptide binding]; other site
395963009363	GTP/Mg2+ binding site [chemical binding]; other site
395963009364	Switch I region; other site
395963009365	G2 box; other site
395963009366	G3 box; other site
395963009367	Switch II region; other site
395963009368	G4 box; other site
395963009369	G5 box; other site
395963009370	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
395963009371	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
395963009372	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
395963009373	glutathione synthetase; Provisional; Region: PRK05246
395963009374	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
395963009375	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
395963009376	PII uridylyl-transferase; Provisional; Region: PRK05092
395963009377	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395963009378	metal binding triad; other site
395963009379	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395963009380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395963009381	Zn2+ binding site [ion binding]; other site
395963009382	Mg2+ binding site [ion binding]; other site
395963009383	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
395963009384	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
395963009385	Predicted membrane protein [Function unknown]; Region: COG2259
395963009386	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
395963009387	hypothetical protein; Provisional; Region: PRK05409
395963009388	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
395963009389	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
395963009390	RNA polymerase sigma factor; Provisional; Region: PRK12512
395963009391	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963009392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963009393	DNA binding residues [nucleotide binding]
395963009394	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
395963009395	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395963009396	RNA binding surface [nucleotide binding]; other site
395963009397	Ferredoxin [Energy production and conversion]; Region: COG1146
395963009398	4Fe-4S binding domain; Region: Fer4; pfam00037
395963009399	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
395963009400	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
395963009401	phosphoserine phosphatase SerB; Region: serB; TIGR00338
395963009402	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395963009403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963009404	motif II; other site
395963009405	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
395963009406	putative active site [active]
395963009407	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
395963009408	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395963009409	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
395963009410	recombination protein F; Reviewed; Region: recF; PRK00064
395963009411	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963009412	Walker A/P-loop; other site
395963009413	ATP binding site [chemical binding]; other site
395963009414	Q-loop/lid; other site
395963009415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963009416	ABC transporter signature motif; other site
395963009417	Walker B; other site
395963009418	D-loop; other site
395963009419	H-loop/switch region; other site
395963009420	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395963009421	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395963009422	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395963009423	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963009424	catalytic loop [active]
395963009425	iron binding site [ion binding]; other site
395963009426	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
395963009427	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395963009428	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
395963009429	Walker A/P-loop; other site
395963009430	ATP binding site [chemical binding]; other site
395963009431	Q-loop/lid; other site
395963009432	ABC transporter signature motif; other site
395963009433	Walker B; other site
395963009434	D-loop; other site
395963009435	H-loop/switch region; other site
395963009436	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
395963009437	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
395963009438	putative NADP binding site [chemical binding]; other site
395963009439	putative substrate binding site [chemical binding]; other site
395963009440	active site
395963009441	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395963009442	active site lid residues [active]
395963009443	substrate binding pocket [chemical binding]; other site
395963009444	catalytic residues [active]
395963009445	substrate-Mg2+ binding site; other site
395963009446	aspartate-rich region 1; other site
395963009447	aspartate-rich region 2; other site
395963009448	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395963009449	active site lid residues [active]
395963009450	substrate binding pocket [chemical binding]; other site
395963009451	catalytic residues [active]
395963009452	substrate-Mg2+ binding site; other site
395963009453	aspartate-rich region 1; other site
395963009454	aspartate-rich region 2; other site
395963009455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395963009456	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
395963009457	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
395963009458	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
395963009459	Active site cavity [active]
395963009460	catalytic acid [active]
395963009461	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
395963009462	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
395963009463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963009464	FeS/SAM binding site; other site
395963009465	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
395963009466	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
395963009467	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
395963009468	Peptidase family M48; Region: Peptidase_M48; cl12018
395963009469	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
395963009470	Catalytic site; other site
395963009471	Helix-turn-helix domain; Region: HTH_17; cl17695
395963009472	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
395963009473	generic binding surface II; other site
395963009474	generic binding surface I; other site
395963009475	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395963009476	Walker A motif; other site
395963009477	ATP binding site [chemical binding]; other site
395963009478	Walker B motif; other site
395963009479	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
395963009480	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
395963009481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963009482	non-specific DNA binding site [nucleotide binding]; other site
395963009483	salt bridge; other site
395963009484	sequence-specific DNA binding site [nucleotide binding]; other site
395963009485	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
395963009486	Protein of unknown function (DUF497); Region: DUF497; cl01108
395963009487	Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097
395963009488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963009489	non-specific DNA binding site [nucleotide binding]; other site
395963009490	salt bridge; other site
395963009491	sequence-specific DNA binding site [nucleotide binding]; other site
395963009492	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395963009493	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
395963009494	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
395963009495	RNase E interface [polypeptide binding]; other site
395963009496	trimer interface [polypeptide binding]; other site
395963009497	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
395963009498	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
395963009499	RNase E interface [polypeptide binding]; other site
395963009500	trimer interface [polypeptide binding]; other site
395963009501	active site
395963009502	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
395963009503	putative nucleic acid binding region [nucleotide binding]; other site
395963009504	G-X-X-G motif; other site
395963009505	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
395963009506	RNA binding site [nucleotide binding]; other site
395963009507	domain interface; other site
395963009508	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
395963009509	16S/18S rRNA binding site [nucleotide binding]; other site
395963009510	S13e-L30e interaction site [polypeptide binding]; other site
395963009511	25S rRNA binding site [nucleotide binding]; other site
395963009512	Predicted integral membrane protein [Function unknown]; Region: COG0392
395963009513	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395963009514	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395963009515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963009516	dimer interface [polypeptide binding]; other site
395963009517	phosphorylation site [posttranslational modification]
395963009518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963009519	ATP binding site [chemical binding]; other site
395963009520	Mg2+ binding site [ion binding]; other site
395963009521	G-X-G motif; other site
395963009522	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
395963009523	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
395963009524	CoA-binding site [chemical binding]; other site
395963009525	ATP-binding [chemical binding]; other site
395963009526	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
395963009527	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
395963009528	active site
395963009529	catalytic site [active]
395963009530	substrate binding site [chemical binding]; other site
395963009531	Helix-turn-helix domain; Region: HTH_17; pfam12728
395963009532	preprotein translocase subunit SecB; Validated; Region: PRK05751
395963009533	SecA binding site; other site
395963009534	Preprotein binding site; other site
395963009535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009536	TPR motif; other site
395963009537	binding surface
395963009538	TPR repeat; Region: TPR_11; pfam13414
395963009539	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009540	binding surface
395963009541	TPR motif; other site
395963009542	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395963009543	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009544	binding surface
395963009545	TPR motif; other site
395963009546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009547	binding surface
395963009548	TPR motif; other site
395963009549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963009550	binding surface
395963009551	TPR motif; other site
395963009552	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395963009553	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
395963009554	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395963009555	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395963009556	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
395963009557	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395963009558	dimer interface [polypeptide binding]; other site
395963009559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395963009560	active site
395963009561	metal binding site [ion binding]; metal-binding site
395963009562	glutathione binding site [chemical binding]; other site
395963009563	Cytochrome c; Region: Cytochrom_C; cl11414
395963009564	BON domain; Region: BON; pfam04972
395963009565	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
395963009566	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
395963009567	aspartate aminotransferase; Provisional; Region: PRK06108
395963009568	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963009569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963009570	homodimer interface [polypeptide binding]; other site
395963009571	catalytic residue [active]
395963009572	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395963009573	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395963009574	substrate-cofactor binding pocket; other site
395963009575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963009576	catalytic residue [active]
395963009577	LTXXQ motif family protein; Region: LTXXQ; pfam07813
395963009578	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395963009579	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
395963009580	inhibitor-cofactor binding pocket; inhibition site
395963009581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963009582	catalytic residue [active]
395963009583	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395963009584	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395963009585	active site
395963009586	dimerization interface [polypeptide binding]; other site
395963009587	elongation factor P; Validated; Region: PRK00529
395963009588	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395963009589	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395963009590	RNA binding site [nucleotide binding]; other site
395963009591	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395963009592	RNA binding site [nucleotide binding]; other site
395963009593	EVE domain; Region: EVE; pfam01878
395963009594	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
395963009595	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395963009596	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
395963009597	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
395963009598	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
395963009599	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
395963009600	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
395963009601	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395963009602	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
395963009603	lysine-2,3-aminomutase-related protein; Region: AblA_like_2; TIGR03822
395963009604	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395963009605	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
395963009606	motif 1; other site
395963009607	dimer interface [polypeptide binding]; other site
395963009608	active site
395963009609	motif 2; other site
395963009610	motif 3; other site
395963009611	elongation factor P; Validated; Region: PRK00529
395963009612	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395963009613	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395963009614	RNA binding site [nucleotide binding]; other site
395963009615	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395963009616	RNA binding site [nucleotide binding]; other site
395963009617	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
395963009618	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395963009619	tetramer interface [polypeptide binding]; other site
395963009620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963009621	catalytic residue [active]
395963009622	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
395963009623	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395963009624	dimer interface [polypeptide binding]; other site
395963009625	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
395963009626	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
395963009627	Predicted transcriptional regulators [Transcription]; Region: COG1733
395963009628	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395963009629	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
395963009630	N-formylglutamate amidohydrolase; Region: FGase; cl01522
395963009631	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
395963009632	transaldolase-like protein; Provisional; Region: PTZ00411
395963009633	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
395963009634	active site
395963009635	dimer interface [polypeptide binding]; other site
395963009636	catalytic residue [active]
395963009637	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
395963009638	dimer interface [polypeptide binding]; other site
395963009639	phosphorylation site [posttranslational modification]
395963009640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963009641	ATP binding site [chemical binding]; other site
395963009642	Mg2+ binding site [ion binding]; other site
395963009643	G-X-G motif; other site
395963009644	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963009645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963009646	active site
395963009647	phosphorylation site [posttranslational modification]
395963009648	intermolecular recognition site; other site
395963009649	dimerization interface [polypeptide binding]; other site
395963009650	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
395963009651	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
395963009652	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
395963009653	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
395963009654	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395963009655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963009656	active site
395963009657	phosphorylation site [posttranslational modification]
395963009658	intermolecular recognition site; other site
395963009659	dimerization interface [polypeptide binding]; other site
395963009660	RNA polymerase sigma factor; Provisional; Region: PRK12547
395963009661	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963009662	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963009663	DNA binding residues [nucleotide binding]
395963009664	fumarate hydratase; Reviewed; Region: fumC; PRK00485
395963009665	Class II fumarases; Region: Fumarase_classII; cd01362
395963009666	active site
395963009667	tetramer interface [polypeptide binding]; other site
395963009668	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395963009669	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395963009670	catalytic triad [active]
395963009671	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395963009672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963009673	NAD(P) binding site [chemical binding]; other site
395963009674	active site
395963009675	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
395963009676	putative metal binding site [ion binding]; other site
395963009677	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
395963009678	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
395963009679	putative tRNA-binding site [nucleotide binding]; other site
395963009680	B3/4 domain; Region: B3_4; pfam03483
395963009681	tRNA synthetase B5 domain; Region: B5; pfam03484
395963009682	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
395963009683	dimer interface [polypeptide binding]; other site
395963009684	motif 1; other site
395963009685	motif 3; other site
395963009686	motif 2; other site
395963009687	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
395963009688	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
395963009689	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
395963009690	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
395963009691	RmuC family; Region: RmuC; pfam02646
395963009692	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395963009693	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
395963009694	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
395963009695	SEC-C motif; Region: SEC-C; pfam02810
395963009696	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
395963009697	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
395963009698	Short C-terminal domain; Region: SHOCT; pfam09851
395963009699	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963009700	Uncharacterized conserved protein [Function unknown]; Region: COG3189
395963009701	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
395963009702	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
395963009703	active site
395963009704	Zn binding site [ion binding]; other site
395963009705	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
395963009706	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
395963009707	dimer interface [polypeptide binding]; other site
395963009708	catalytic residues [active]
395963009709	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
395963009710	UreF; Region: UreF; pfam01730
395963009711	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
395963009712	G1 box; other site
395963009713	GTP/Mg2+ binding site [chemical binding]; other site
395963009714	Switch I region; other site
395963009715	G3 box; other site
395963009716	Switch II region; other site
395963009717	G4 box; other site
395963009718	G5 box; other site
395963009719	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395963009720	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395963009721	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
395963009722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395963009723	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
395963009724	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
395963009725	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395963009726	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
395963009727	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395963009728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963009729	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395963009730	putative effector binding pocket; other site
395963009731	dimerization interface [polypeptide binding]; other site
395963009732	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395963009733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963009734	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
395963009735	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395963009736	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
395963009737	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395963009738	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395963009739	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395963009740	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395963009741	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963009742	substrate binding site [chemical binding]; other site
395963009743	oxyanion hole (OAH) forming residues; other site
395963009744	trimer interface [polypeptide binding]; other site
395963009745	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
395963009746	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
395963009747	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395963009748	active site
395963009749	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
395963009750	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395963009751	Ligand binding site [chemical binding]; other site
395963009752	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395963009753	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395963009754	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395963009755	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395963009756	Coenzyme A transferase; Region: CoA_trans; cl17247
395963009757	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
395963009758	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395963009759	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395963009760	substrate binding site [chemical binding]; other site
395963009761	oxyanion hole (OAH) forming residues; other site
395963009762	trimer interface [polypeptide binding]; other site
395963009763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395963009764	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395963009765	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395963009766	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395963009767	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395963009768	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
395963009769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395963009770	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395963009771	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
395963009772	MPT binding site; other site
395963009773	trimer interface [polypeptide binding]; other site
395963009774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
395963009775	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395963009776	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
395963009777	putative ligand binding site [chemical binding]; other site
395963009778	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
395963009779	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
395963009780	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
395963009781	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
395963009782	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
395963009783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963009784	putative substrate translocation pore; other site
395963009785	glucokinase, proteobacterial type; Region: glk; TIGR00749
395963009786	Glucokinase; Region: Glucokinase; pfam02685
395963009787	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
395963009788	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395963009789	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395963009790	shikimate binding site; other site
395963009791	NAD(P) binding site [chemical binding]; other site
395963009792	MarR family; Region: MarR_2; pfam12802
395963009793	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
395963009794	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395963009795	Yqey-like protein; Region: YqeY; pfam09424
395963009796	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
395963009797	oligomerization interface [polypeptide binding]; other site
395963009798	active site
395963009799	metal binding site [ion binding]; metal-binding site
395963009800	DNA primase, catalytic core; Region: dnaG; TIGR01391
395963009801	CHC2 zinc finger; Region: zf-CHC2; pfam01807
395963009802	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
395963009803	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
395963009804	active site
395963009805	metal binding site [ion binding]; metal-binding site
395963009806	interdomain interaction site; other site
395963009807	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
395963009808	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
395963009809	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
395963009810	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395963009811	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
395963009812	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395963009813	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395963009814	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395963009815	DNA binding residues [nucleotide binding]
395963009816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
395963009817	Helix-turn-helix domain; Region: HTH_28; pfam13518
395963009818	DDE superfamily endonuclease; Region: DDE_3; pfam13358
395963009819	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
395963009820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963009821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395963009822	dimerization interface [polypeptide binding]; other site
395963009823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963009824	dimer interface [polypeptide binding]; other site
395963009825	phosphorylation site [posttranslational modification]
395963009826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963009827	ATP binding site [chemical binding]; other site
395963009828	Mg2+ binding site [ion binding]; other site
395963009829	G-X-G motif; other site
395963009830	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
395963009831	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963009832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963009833	active site
395963009834	phosphorylation site [posttranslational modification]
395963009835	intermolecular recognition site; other site
395963009836	dimerization interface [polypeptide binding]; other site
395963009837	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963009838	DNA binding site [nucleotide binding]
395963009839	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
395963009840	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395963009841	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963009842	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
395963009843	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
395963009844	alpha-gamma subunit interface [polypeptide binding]; other site
395963009845	beta-gamma subunit interface [polypeptide binding]; other site
395963009846	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
395963009847	gamma-beta subunit interface [polypeptide binding]; other site
395963009848	alpha-beta subunit interface [polypeptide binding]; other site
395963009849	UreD urease accessory protein; Region: UreD; pfam01774
395963009850	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
395963009851	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
395963009852	GSH binding site [chemical binding]; other site
395963009853	catalytic residues [active]
395963009854	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
395963009855	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
395963009856	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395963009857	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395963009858	C-terminal domain interface [polypeptide binding]; other site
395963009859	GSH binding site (G-site) [chemical binding]; other site
395963009860	dimer interface [polypeptide binding]; other site
395963009861	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395963009862	N-terminal domain interface [polypeptide binding]; other site
395963009863	dimer interface [polypeptide binding]; other site
395963009864	substrate binding pocket (H-site) [chemical binding]; other site
395963009865	epoxyqueuosine reductase; Region: TIGR00276
395963009866	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
395963009867	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395963009868	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
395963009869	putative NAD(P) binding site [chemical binding]; other site
395963009870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
395963009871	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395963009872	phosphate binding site [ion binding]; other site
395963009873	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
395963009874	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
395963009875	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
395963009876	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963009877	FeS/SAM binding site; other site
395963009878	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
395963009879	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
395963009880	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
395963009881	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
395963009882	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
395963009883	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
395963009884	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395963009885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963009886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395963009887	dimer interface [polypeptide binding]; other site
395963009888	phosphorylation site [posttranslational modification]
395963009889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963009890	ATP binding site [chemical binding]; other site
395963009891	Mg2+ binding site [ion binding]; other site
395963009892	G-X-G motif; other site
395963009893	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
395963009894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963009895	active site
395963009896	phosphorylation site [posttranslational modification]
395963009897	intermolecular recognition site; other site
395963009898	dimerization interface [polypeptide binding]; other site
395963009899	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
395963009900	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
395963009901	Ribonuclease P; Region: Ribonuclease_P; cl00457
395963009902	membrane protein insertase; Provisional; Region: PRK01318
395963009903	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
395963009904	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
395963009905	G1 box; other site
395963009906	GTP/Mg2+ binding site [chemical binding]; other site
395963009907	Switch I region; other site
395963009908	G2 box; other site
395963009909	G3 box; other site
395963009910	Switch II region; other site
395963009911	G4 box; other site
395963009912	G5 box; other site
395963009913	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
395963009914	feedback inhibition sensing region; other site
395963009915	homohexameric interface [polypeptide binding]; other site
395963009916	nucleotide binding site [chemical binding]; other site
395963009917	N-acetyl-L-glutamate binding site [chemical binding]; other site
395963009918	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
395963009919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395963009920	motif II; other site
395963009921	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
395963009922	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
395963009923	trimer interface [polypeptide binding]; other site
395963009924	active site
395963009925	substrate binding site [chemical binding]; other site
395963009926	CoA binding site [chemical binding]; other site
395963009927	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395963009928	Fe-S cluster binding site [ion binding]; other site
395963009929	active site
395963009930	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
395963009931	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
395963009932	metal binding site [ion binding]; metal-binding site
395963009933	dimer interface [polypeptide binding]; other site
395963009934	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395963009935	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
395963009936	dimer interface [polypeptide binding]; other site
395963009937	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395963009938	catalytic triad [active]
395963009939	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963009940	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963009941	active site
395963009942	catalytic tetrad [active]
395963009943	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
395963009944	succinic semialdehyde dehydrogenase; Region: PLN02278
395963009945	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
395963009946	tetramerization interface [polypeptide binding]; other site
395963009947	NAD(P) binding site [chemical binding]; other site
395963009948	catalytic residues [active]
395963009949	hypothetical protein; Validated; Region: PRK09039
395963009950	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395963009951	ligand binding site [chemical binding]; other site
395963009952	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395963009953	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
395963009954	inner membrane protein; Provisional; Region: PRK10995
395963009955	signal recognition particle protein; Provisional; Region: PRK10867
395963009956	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395963009957	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395963009958	P loop; other site
395963009959	GTP binding site [chemical binding]; other site
395963009960	Signal peptide binding domain; Region: SRP_SPB; pfam02978
395963009961	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
395963009962	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
395963009963	RimM N-terminal domain; Region: RimM; pfam01782
395963009964	PRC-barrel domain; Region: PRC; pfam05239
395963009965	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
395963009966	prephenate dehydratase; Provisional; Region: PRK11899
395963009967	Prephenate dehydratase; Region: PDT; pfam00800
395963009968	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
395963009969	putative L-Phe binding site [chemical binding]; other site
395963009970	Cytochrome c2 [Energy production and conversion]; Region: COG3474
395963009971	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395963009972	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395963009973	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
395963009974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963009975	dimer interface [polypeptide binding]; other site
395963009976	conserved gate region; other site
395963009977	putative PBP binding loops; other site
395963009978	ABC-ATPase subunit interface; other site
395963009979	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
395963009980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963009981	dimer interface [polypeptide binding]; other site
395963009982	conserved gate region; other site
395963009983	ABC-ATPase subunit interface; other site
395963009984	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395963009985	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963009986	Walker A/P-loop; other site
395963009987	ATP binding site [chemical binding]; other site
395963009988	Q-loop/lid; other site
395963009989	ABC transporter signature motif; other site
395963009990	Walker B; other site
395963009991	D-loop; other site
395963009992	H-loop/switch region; other site
395963009993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963009994	Walker A/P-loop; other site
395963009995	ATP binding site [chemical binding]; other site
395963009996	Q-loop/lid; other site
395963009997	ABC transporter signature motif; other site
395963009998	Walker B; other site
395963009999	D-loop; other site
395963010000	H-loop/switch region; other site
395963010001	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
395963010002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010003	active site
395963010004	phosphorylation site [posttranslational modification]
395963010005	intermolecular recognition site; other site
395963010006	dimerization interface [polypeptide binding]; other site
395963010007	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
395963010008	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395963010009	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395963010010	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963010011	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963010012	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395963010013	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395963010014	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395963010015	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395963010016	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395963010017	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
395963010018	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963010019	catalytic loop [active]
395963010020	iron binding site [ion binding]; other site
395963010021	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395963010022	Cytochrome c; Region: Cytochrom_C; pfam00034
395963010023	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395963010024	Cytochrome c; Region: Cytochrom_C; pfam00034
395963010025	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395963010026	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395963010027	active site
395963010028	oxyanion hole [active]
395963010029	catalytic triad [active]
395963010030	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
395963010031	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
395963010032	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
395963010033	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395963010034	DNA binding residues [nucleotide binding]
395963010035	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395963010036	IHF dimer interface [polypeptide binding]; other site
395963010037	IHF - DNA interface [nucleotide binding]; other site
395963010038	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395963010039	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395963010040	dimer interface [polypeptide binding]; other site
395963010041	active site
395963010042	CoA binding pocket [chemical binding]; other site
395963010043	putative phosphate acyltransferase; Provisional; Region: PRK05331
395963010044	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
395963010045	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
395963010046	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
395963010047	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
395963010048	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395963010049	putative catalytic site [active]
395963010050	putative metal binding site [ion binding]; other site
395963010051	putative catalytic site [active]
395963010052	putative phosphate binding site [ion binding]; other site
395963010053	putative phosphate binding site [ion binding]; other site
395963010054	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
395963010055	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395963010056	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
395963010057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395963010058	active site
395963010059	dimerization interface [polypeptide binding]; other site
395963010060	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963010061	DNA binding site [nucleotide binding]
395963010062	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
395963010063	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
395963010064	dimer interface [polypeptide binding]; other site
395963010065	PYR/PP interface [polypeptide binding]; other site
395963010066	TPP binding site [chemical binding]; other site
395963010067	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395963010068	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
395963010069	TPP-binding site [chemical binding]; other site
395963010070	dimer interface [polypeptide binding]; other site
395963010071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963010072	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
395963010073	putative substrate translocation pore; other site
395963010074	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
395963010075	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395963010076	GAF domain; Region: GAF; pfam01590
395963010077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963010078	Walker A motif; other site
395963010079	ATP binding site [chemical binding]; other site
395963010080	Walker B motif; other site
395963010081	arginine finger; other site
395963010082	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395963010083	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395963010084	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
395963010085	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
395963010086	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
395963010087	dimerization interface [polypeptide binding]; other site
395963010088	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
395963010089	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395963010090	catalytic loop [active]
395963010091	iron binding site [ion binding]; other site
395963010092	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
395963010093	FAD binding pocket [chemical binding]; other site
395963010094	FAD binding motif [chemical binding]; other site
395963010095	phosphate binding motif [ion binding]; other site
395963010096	beta-alpha-beta structure motif; other site
395963010097	NAD binding pocket [chemical binding]; other site
395963010098	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
395963010099	dimerization interface [polypeptide binding]; other site
395963010100	putative path to active site cavity [active]
395963010101	diiron center [ion binding]; other site
395963010102	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
395963010103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963010104	FeS/SAM binding site; other site
395963010105	HemN C-terminal domain; Region: HemN_C; pfam06969
395963010106	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
395963010107	ArsC family; Region: ArsC; pfam03960
395963010108	catalytic residues [active]
395963010109	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395963010110	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395963010111	ligand binding site [chemical binding]; other site
395963010112	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
395963010113	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395963010114	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
395963010115	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395963010116	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
395963010117	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395963010118	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395963010119	FeS/SAM binding site; other site
395963010120	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
395963010121	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395963010122	active site
395963010123	DNA binding site [nucleotide binding]
395963010124	Int/Topo IB signature motif; other site
395963010125	PBP superfamily domain; Region: PBP_like_2; cl17296
395963010126	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
395963010127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963010128	dimer interface [polypeptide binding]; other site
395963010129	conserved gate region; other site
395963010130	putative PBP binding loops; other site
395963010131	ABC-ATPase subunit interface; other site
395963010132	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
395963010133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963010134	dimer interface [polypeptide binding]; other site
395963010135	conserved gate region; other site
395963010136	ABC-ATPase subunit interface; other site
395963010137	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
395963010138	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395963010139	Walker A/P-loop; other site
395963010140	ATP binding site [chemical binding]; other site
395963010141	Q-loop/lid; other site
395963010142	ABC transporter signature motif; other site
395963010143	Walker B; other site
395963010144	D-loop; other site
395963010145	H-loop/switch region; other site
395963010146	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
395963010147	PhoU domain; Region: PhoU; pfam01895
395963010148	PhoU domain; Region: PhoU; pfam01895
395963010149	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
395963010150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010151	active site
395963010152	phosphorylation site [posttranslational modification]
395963010153	intermolecular recognition site; other site
395963010154	dimerization interface [polypeptide binding]; other site
395963010155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963010156	DNA binding site [nucleotide binding]
395963010157	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
395963010158	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
395963010159	active site
395963010160	ribonuclease R; Region: RNase_R; TIGR02063
395963010161	RNB domain; Region: RNB; pfam00773
395963010162	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
395963010163	RNA binding site [nucleotide binding]; other site
395963010164	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
395963010165	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
395963010166	active site
395963010167	interdomain interaction site; other site
395963010168	putative metal-binding site [ion binding]; other site
395963010169	nucleotide binding site [chemical binding]; other site
395963010170	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
395963010171	domain I; other site
395963010172	DNA binding groove [nucleotide binding]
395963010173	phosphate binding site [ion binding]; other site
395963010174	domain II; other site
395963010175	domain III; other site
395963010176	nucleotide binding site [chemical binding]; other site
395963010177	catalytic site [active]
395963010178	domain IV; other site
395963010179	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
395963010180	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395963010181	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395963010182	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395963010183	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395963010184	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
395963010185	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395963010186	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395963010187	dihydroorotase; Validated; Region: PRK09059
395963010188	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395963010189	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
395963010190	active site
395963010191	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
395963010192	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
395963010193	DNA protecting protein DprA; Region: dprA; TIGR00732
395963010194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395963010195	Coenzyme A binding pocket [chemical binding]; other site
395963010196	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395963010197	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
395963010198	Cl binding site [ion binding]; other site
395963010199	oligomer interface [polypeptide binding]; other site
395963010200	PRC-barrel domain; Region: PRC; pfam05239
395963010201	PRC-barrel domain; Region: PRC; pfam05239
395963010202	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
395963010203	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
395963010204	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
395963010205	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
395963010206	metal ion-dependent adhesion site (MIDAS); other site
395963010207	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
395963010208	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
395963010209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395963010210	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395963010211	HSP70 interaction site [polypeptide binding]; other site
395963010212	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395963010213	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395963010214	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
395963010215	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
395963010216	Domain interface; other site
395963010217	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
395963010218	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395963010219	FMN-binding domain; Region: FMN_bind; pfam04205
395963010220	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
395963010221	ApbE family; Region: ApbE; pfam02424
395963010222	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
395963010223	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
395963010224	acyl-activating enzyme (AAE) consensus motif; other site
395963010225	putative AMP binding site [chemical binding]; other site
395963010226	putative active site [active]
395963010227	putative CoA binding site [chemical binding]; other site
395963010228	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
395963010229	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395963010230	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
395963010231	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395963010232	Bacterial transcriptional regulator; Region: IclR; pfam01614
395963010233	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
395963010234	putative active site [active]
395963010235	putative metal binding site [ion binding]; other site
395963010236	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395963010237	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395963010238	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
395963010239	diiron binding motif [ion binding]; other site
395963010240	Uncharacterized conserved protein [Function unknown]; Region: COG1633
395963010241	CCC1-related family of proteins; Region: CCC1_like; cl00278
395963010242	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395963010243	nudix motif; other site
395963010244	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963010245	HAMP domain; Region: HAMP; pfam00672
395963010246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
395963010247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963010248	ATP binding site [chemical binding]; other site
395963010249	Mg2+ binding site [ion binding]; other site
395963010250	G-X-G motif; other site
395963010251	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963010252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010253	active site
395963010254	phosphorylation site [posttranslational modification]
395963010255	intermolecular recognition site; other site
395963010256	dimerization interface [polypeptide binding]; other site
395963010257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963010258	DNA binding site [nucleotide binding]
395963010259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
395963010260	Peptidase M15; Region: Peptidase_M15_3; cl01194
395963010261	D-lactate dehydrogenase; Provisional; Region: PRK11183
395963010262	FAD binding domain; Region: FAD_binding_4; pfam01565
395963010263	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
395963010264	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
395963010265	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
395963010266	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
395963010267	cell density-dependent motility repressor; Provisional; Region: PRK10082
395963010268	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395963010269	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395963010270	dimerization interface [polypeptide binding]; other site
395963010271	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
395963010272	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
395963010273	substrate binding site [chemical binding]; other site
395963010274	ligand binding site [chemical binding]; other site
395963010275	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
395963010276	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
395963010277	substrate binding site [chemical binding]; other site
395963010278	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
395963010279	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
395963010280	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395963010281	nitrilase; Region: PLN02798
395963010282	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
395963010283	putative active site [active]
395963010284	catalytic triad [active]
395963010285	dimer interface [polypeptide binding]; other site
395963010286	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
395963010287	peptide binding site [polypeptide binding]; other site
395963010288	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395963010289	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
395963010290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963010291	dimer interface [polypeptide binding]; other site
395963010292	conserved gate region; other site
395963010293	putative PBP binding loops; other site
395963010294	ABC-ATPase subunit interface; other site
395963010295	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
395963010296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395963010297	dimer interface [polypeptide binding]; other site
395963010298	conserved gate region; other site
395963010299	putative PBP binding loops; other site
395963010300	ABC-ATPase subunit interface; other site
395963010301	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395963010302	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963010303	Walker A/P-loop; other site
395963010304	ATP binding site [chemical binding]; other site
395963010305	Q-loop/lid; other site
395963010306	ABC transporter signature motif; other site
395963010307	Walker B; other site
395963010308	D-loop; other site
395963010309	H-loop/switch region; other site
395963010310	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395963010311	Walker A/P-loop; other site
395963010312	ATP binding site [chemical binding]; other site
395963010313	Q-loop/lid; other site
395963010314	ABC transporter signature motif; other site
395963010315	Walker B; other site
395963010316	D-loop; other site
395963010317	H-loop/switch region; other site
395963010318	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395963010319	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
395963010320	active site
395963010321	intersubunit interface [polypeptide binding]; other site
395963010322	catalytic residue [active]
395963010323	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
395963010324	Phosphoglycerate kinase; Region: PGK; pfam00162
395963010325	substrate binding site [chemical binding]; other site
395963010326	hinge regions; other site
395963010327	ADP binding site [chemical binding]; other site
395963010328	catalytic site [active]
395963010329	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
395963010330	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
395963010331	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395963010332	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
395963010333	Cell division protein ZapA; Region: ZapA; pfam05164
395963010334	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
395963010335	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
395963010336	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
395963010337	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395963010338	putative active site [active]
395963010339	metal binding site [ion binding]; metal-binding site
395963010340	homodimer binding site [polypeptide binding]; other site
395963010341	CopC domain; Region: CopC; pfam04234
395963010342	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
395963010343	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
395963010344	ferrochelatase; Reviewed; Region: hemH; PRK00035
395963010345	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
395963010346	C-terminal domain interface [polypeptide binding]; other site
395963010347	active site
395963010348	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
395963010349	active site
395963010350	N-terminal domain interface [polypeptide binding]; other site
395963010351	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395963010352	active site
395963010353	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
395963010354	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395963010355	active site
395963010356	metal binding site [ion binding]; metal-binding site
395963010357	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
395963010358	Predicted membrane protein [Function unknown]; Region: COG3762
395963010359	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
395963010360	Repair protein; Region: Repair_PSII; pfam04536
395963010361	LemA family; Region: LemA; pfam04011
395963010362	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
395963010363	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
395963010364	amphipathic channel; other site
395963010365	Asn-Pro-Ala signature motifs; other site
395963010366	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
395963010367	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395963010368	dimer interface [polypeptide binding]; other site
395963010369	active site
395963010370	Phosphopantetheine attachment site; Region: PP-binding; cl09936
395963010371	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
395963010372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963010373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963010374	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
395963010375	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395963010376	ATP binding site [chemical binding]; other site
395963010377	putative Mg++ binding site [ion binding]; other site
395963010378	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395963010379	nucleotide binding region [chemical binding]; other site
395963010380	ATP-binding site [chemical binding]; other site
395963010381	RQC domain; Region: RQC; pfam09382
395963010382	HRDC domain; Region: HRDC; pfam00570
395963010383	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
395963010384	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
395963010385	dimerization interface [polypeptide binding]; other site
395963010386	active site
395963010387	L-aspartate oxidase; Provisional; Region: PRK07512
395963010388	L-aspartate oxidase; Provisional; Region: PRK06175
395963010389	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395963010390	quinolinate synthetase; Provisional; Region: PRK09375
395963010391	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
395963010392	hypothetical protein; Provisional; Region: PRK14679
395963010393	Predicted methyltransferases [General function prediction only]; Region: COG0313
395963010394	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
395963010395	putative SAM binding site [chemical binding]; other site
395963010396	putative homodimer interface [polypeptide binding]; other site
395963010397	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
395963010398	mce related protein; Region: MCE; pfam02470
395963010399	Protein of unknown function (DUF330); Region: DUF330; cl01135
395963010400	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
395963010401	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
395963010402	Walker A/P-loop; other site
395963010403	ATP binding site [chemical binding]; other site
395963010404	Q-loop/lid; other site
395963010405	ABC transporter signature motif; other site
395963010406	Walker B; other site
395963010407	D-loop; other site
395963010408	H-loop/switch region; other site
395963010409	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
395963010410	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395963010411	Permease; Region: Permease; pfam02405
395963010412	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
395963010413	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395963010414	NADP binding site [chemical binding]; other site
395963010415	active site
395963010416	putative substrate binding site [chemical binding]; other site
395963010417	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
395963010418	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
395963010419	NAD binding site [chemical binding]; other site
395963010420	substrate binding site [chemical binding]; other site
395963010421	homodimer interface [polypeptide binding]; other site
395963010422	active site
395963010423	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
395963010424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963010425	Walker A motif; other site
395963010426	ATP binding site [chemical binding]; other site
395963010427	Walker B motif; other site
395963010428	Family description; Region: UvrD_C_2; pfam13538
395963010429	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
395963010430	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395963010431	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395963010432	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
395963010433	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395963010434	precorrin-3B synthase; Region: CobG; TIGR02435
395963010435	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
395963010436	Precorrin-8X methylmutase; Region: CbiC; pfam02570
395963010437	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
395963010438	homodimer interface [polypeptide binding]; other site
395963010439	active site
395963010440	SAM binding site [chemical binding]; other site
395963010441	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
395963010442	active site
395963010443	SAM binding site [chemical binding]; other site
395963010444	homodimer interface [polypeptide binding]; other site
395963010445	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
395963010446	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
395963010447	active site
395963010448	putative homodimer interface [polypeptide binding]; other site
395963010449	SAM binding site [chemical binding]; other site
395963010450	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
395963010451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395963010452	S-adenosylmethionine binding site [chemical binding]; other site
395963010453	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
395963010454	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
395963010455	active site
395963010456	SAM binding site [chemical binding]; other site
395963010457	homodimer interface [polypeptide binding]; other site
395963010458	Fic/DOC family; Region: Fic; pfam02661
395963010459	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
395963010460	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
395963010461	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395963010462	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
395963010463	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395963010464	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395963010465	active site
395963010466	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395963010467	Sel1-like repeats; Region: SEL1; smart00671
395963010468	Sel1-like repeats; Region: SEL1; smart00671
395963010469	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395963010470	thiamine phosphate binding site [chemical binding]; other site
395963010471	active site
395963010472	pyrophosphate binding site [ion binding]; other site
395963010473	Transcriptional regulators [Transcription]; Region: FadR; COG2186
395963010474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395963010475	DNA-binding site [nucleotide binding]; DNA binding site
395963010476	FCD domain; Region: FCD; pfam07729
395963010477	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
395963010478	homodimer interface [polypeptide binding]; other site
395963010479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963010480	catalytic residue [active]
395963010481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395963010482	D-galactonate transporter; Region: 2A0114; TIGR00893
395963010483	putative substrate translocation pore; other site
395963010484	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395963010485	oligomeric interface; other site
395963010486	putative active site [active]
395963010487	homodimer interface [polypeptide binding]; other site
395963010488	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395963010489	Cupin; Region: Cupin_6; pfam12852
395963010490	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963010491	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395963010492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395963010493	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395963010494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963010495	ATP binding site [chemical binding]; other site
395963010496	Mg2+ binding site [ion binding]; other site
395963010497	G-X-G motif; other site
395963010498	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
395963010499	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
395963010500	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
395963010501	catalytic site [active]
395963010502	subunit interface [polypeptide binding]; other site
395963010503	Methyltransferase domain; Region: Methyltransf_12; pfam08242
395963010504	S-adenosylmethionine binding site [chemical binding]; other site
395963010505	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
395963010506	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
395963010507	Uncharacterized conserved protein [Function unknown]; Region: COG1565
395963010508	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
395963010509	Membrane fusogenic activity; Region: BMFP; pfam04380
395963010510	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
395963010511	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
395963010512	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
395963010513	ligand binding site [chemical binding]; other site
395963010514	homodimer interface [polypeptide binding]; other site
395963010515	NAD(P) binding site [chemical binding]; other site
395963010516	trimer interface B [polypeptide binding]; other site
395963010517	trimer interface A [polypeptide binding]; other site
395963010518	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
395963010519	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
395963010520	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
395963010521	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
395963010522	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
395963010523	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395963010524	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
395963010525	homodimer interface [polypeptide binding]; other site
395963010526	substrate-cofactor binding pocket; other site
395963010527	catalytic residue [active]
395963010528	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395963010529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010530	active site
395963010531	phosphorylation site [posttranslational modification]
395963010532	intermolecular recognition site; other site
395963010533	dimerization interface [polypeptide binding]; other site
395963010534	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395963010535	DNA binding site [nucleotide binding]
395963010536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395963010537	HAMP domain; Region: HAMP; pfam00672
395963010538	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
395963010539	dimer interface [polypeptide binding]; other site
395963010540	phosphorylation site [posttranslational modification]
395963010541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963010542	ATP binding site [chemical binding]; other site
395963010543	Mg2+ binding site [ion binding]; other site
395963010544	G-X-G motif; other site
395963010545	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
395963010546	CPxP  motif; other site
395963010547	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395963010548	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
395963010549	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
395963010550	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
395963010551	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
395963010552	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
395963010553	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
395963010554	Flagellar protein FlaF; Region: FlaF; pfam07309
395963010555	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
395963010556	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395963010557	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395963010558	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
395963010559	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395963010560	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
395963010561	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395963010562	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
395963010563	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395963010564	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395963010565	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
395963010566	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395963010567	putative active site pocket [active]
395963010568	dimerization interface [polypeptide binding]; other site
395963010569	putative catalytic residue [active]
395963010570	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395963010571	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395963010572	putative acyl-acceptor binding pocket; other site
395963010573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963010574	non-specific DNA binding site [nucleotide binding]; other site
395963010575	salt bridge; other site
395963010576	sequence-specific DNA binding site [nucleotide binding]; other site
395963010577	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
395963010578	putative heme binding pocket [chemical binding]; other site
395963010579	transcription termination factor Rho; Provisional; Region: rho; PRK09376
395963010580	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
395963010581	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
395963010582	RNA binding site [nucleotide binding]; other site
395963010583	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
395963010584	multimer interface [polypeptide binding]; other site
395963010585	Walker A motif; other site
395963010586	ATP binding site [chemical binding]; other site
395963010587	Walker B motif; other site
395963010588	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
395963010589	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
395963010590	substrate binding site [chemical binding]; other site
395963010591	active site
395963010592	PEP synthetase regulatory protein; Provisional; Region: PRK05339
395963010593	Maf-like protein; Region: Maf; pfam02545
395963010594	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
395963010595	putative active site [active]
395963010596	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
395963010597	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395963010598	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395963010599	shikimate binding site; other site
395963010600	NAD(P) binding site [chemical binding]; other site
395963010601	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395963010602	dimer interface [polypeptide binding]; other site
395963010603	[2Fe-2S] cluster binding site [ion binding]; other site
395963010604	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963010605	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
395963010606	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
395963010607	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395963010608	Protein of unknown function (DUF556); Region: DUF556; cl00822
395963010609	Dihydroneopterin aldolase; Region: FolB; pfam02152
395963010610	active site
395963010611	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
395963010612	aromatic arch; other site
395963010613	DCoH dimer interaction site [polypeptide binding]; other site
395963010614	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
395963010615	DCoH tetramer interaction site [polypeptide binding]; other site
395963010616	substrate binding site [chemical binding]; other site
395963010617	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
395963010618	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
395963010619	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
395963010620	active site
395963010621	substrate binding site [chemical binding]; other site
395963010622	metal binding site [ion binding]; metal-binding site
395963010623	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
395963010624	putative active site [active]
395963010625	catalytic residue [active]
395963010626	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
395963010627	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
395963010628	5S rRNA interface [nucleotide binding]; other site
395963010629	CTC domain interface [polypeptide binding]; other site
395963010630	L16 interface [polypeptide binding]; other site
395963010631	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395963010632	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395963010633	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
395963010634	Rod binding protein; Region: Rod-binding; pfam10135
395963010635	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
395963010636	FHIPEP family; Region: FHIPEP; pfam00771
395963010637	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
395963010638	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
395963010639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395963010640	NAD(P) binding site [chemical binding]; other site
395963010641	active site
395963010642	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
395963010643	Cupin domain; Region: Cupin_2; cl17218
395963010644	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395963010645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395963010646	Walker A/P-loop; other site
395963010647	ATP binding site [chemical binding]; other site
395963010648	ABC transporter signature motif; other site
395963010649	Walker B; other site
395963010650	D-loop; other site
395963010651	H-loop/switch region; other site
395963010652	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
395963010653	Walker A/P-loop; other site
395963010654	ATP binding site [chemical binding]; other site
395963010655	Q-loop/lid; other site
395963010656	ABC transporter signature motif; other site
395963010657	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395963010658	Walker B; other site
395963010659	D-loop; other site
395963010660	H-loop/switch region; other site
395963010661	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
395963010662	homotrimer interface [polypeptide binding]; other site
395963010663	Walker A motif; other site
395963010664	GTP binding site [chemical binding]; other site
395963010665	Walker B motif; other site
395963010666	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395963010667	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395963010668	non-specific DNA binding site [nucleotide binding]; other site
395963010669	salt bridge; other site
395963010670	sequence-specific DNA binding site [nucleotide binding]; other site
395963010671	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395963010672	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395963010673	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395963010674	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395963010675	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395963010676	DNA binding residues [nucleotide binding]
395963010677	dimerization interface [polypeptide binding]; other site
395963010678	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
395963010679	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395963010680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395963010681	homodimer interface [polypeptide binding]; other site
395963010682	catalytic residue [active]
395963010683	Predicted ATPase [General function prediction only]; Region: COG1485
395963010684	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395963010685	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395963010686	malate dehydrogenase; Reviewed; Region: PRK06223
395963010687	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
395963010688	NAD(P) binding site [chemical binding]; other site
395963010689	dimer interface [polypeptide binding]; other site
395963010690	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395963010691	substrate binding site [chemical binding]; other site
395963010692	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
395963010693	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
395963010694	CoA-ligase; Region: Ligase_CoA; pfam00549
395963010695	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
395963010696	CoA binding domain; Region: CoA_binding; pfam02629
395963010697	CoA-ligase; Region: Ligase_CoA; pfam00549
395963010698	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
395963010699	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
395963010700	TPP-binding site [chemical binding]; other site
395963010701	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
395963010702	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
395963010703	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395963010704	E3 interaction surface; other site
395963010705	lipoyl attachment site [posttranslational modification]; other site
395963010706	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395963010707	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
395963010708	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395963010709	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395963010710	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395963010711	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
395963010712	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
395963010713	putative active site [active]
395963010714	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963010715	TPR motif; other site
395963010716	TPR repeat; Region: TPR_11; pfam13414
395963010717	binding surface
395963010718	TPR repeat; Region: TPR_11; pfam13414
395963010719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963010720	binding surface
395963010721	TPR motif; other site
395963010722	TPR repeat; Region: TPR_11; pfam13414
395963010723	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395963010724	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395963010725	RecX family; Region: RecX; pfam02631
395963010726	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
395963010727	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395963010728	catalytic residues [active]
395963010729	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
395963010730	Phosphoesterase family; Region: Phosphoesterase; pfam04185
395963010731	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963010732	Domain of unknown function (DUF756); Region: DUF756; pfam05506
395963010733	Predicted membrane protein [Function unknown]; Region: COG4803
395963010734	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395963010735	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395963010736	CHASE3 domain; Region: CHASE3; cl05000
395963010737	HAMP domain; Region: HAMP; pfam00672
395963010738	dimerization interface [polypeptide binding]; other site
395963010739	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395963010740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395963010741	dimer interface [polypeptide binding]; other site
395963010742	putative CheW interface [polypeptide binding]; other site
395963010743	STAS domain; Region: STAS_2; pfam13466
395963010744	Response regulator receiver domain; Region: Response_reg; pfam00072
395963010745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010746	active site
395963010747	phosphorylation site [posttranslational modification]
395963010748	intermolecular recognition site; other site
395963010749	dimerization interface [polypeptide binding]; other site
395963010750	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395963010751	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395963010752	putative binding surface; other site
395963010753	active site
395963010754	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395963010755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395963010756	ATP binding site [chemical binding]; other site
395963010757	Mg2+ binding site [ion binding]; other site
395963010758	G-X-G motif; other site
395963010759	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
395963010760	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
395963010761	putative CheA interaction surface; other site
395963010762	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
395963010763	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395963010764	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
395963010765	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
395963010766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010767	active site
395963010768	phosphorylation site [posttranslational modification]
395963010769	intermolecular recognition site; other site
395963010770	dimerization interface [polypeptide binding]; other site
395963010771	CheB methylesterase; Region: CheB_methylest; pfam01339
395963010772	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
395963010773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010774	active site
395963010775	phosphorylation site [posttranslational modification]
395963010776	intermolecular recognition site; other site
395963010777	dimerization interface [polypeptide binding]; other site
395963010778	CheD chemotactic sensory transduction; Region: CheD; cl00810
395963010779	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395963010780	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395963010781	putative acyl-acceptor binding pocket; other site
395963010782	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
395963010783	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
395963010784	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
395963010785	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
395963010786	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
395963010787	ATP binding site [chemical binding]; other site
395963010788	substrate interface [chemical binding]; other site
395963010789	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
395963010790	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
395963010791	active site
395963010792	substrate binding site [chemical binding]; other site
395963010793	metal binding site [ion binding]; metal-binding site
395963010794	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
395963010795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395963010796	binding surface
395963010797	TPR motif; other site
395963010798	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
395963010799	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
395963010800	Ligand Binding Site [chemical binding]; other site
395963010801	FtsH Extracellular; Region: FtsH_ext; pfam06480
395963010802	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
395963010803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395963010804	Walker A motif; other site
395963010805	ATP binding site [chemical binding]; other site
395963010806	Walker B motif; other site
395963010807	arginine finger; other site
395963010808	Peptidase family M41; Region: Peptidase_M41; pfam01434
395963010809	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395963010810	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
395963010811	dimer interface [polypeptide binding]; other site
395963010812	Trp docking motif [polypeptide binding]; other site
395963010813	active site
395963010814	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395963010815	membrane-bound complex binding site; other site
395963010816	hinge residues; other site
395963010817	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395963010818	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395963010819	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395963010820	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395963010821	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
395963010822	active site
395963010823	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
395963010824	Response regulator receiver domain; Region: Response_reg; pfam00072
395963010825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395963010826	active site
395963010827	phosphorylation site [posttranslational modification]
395963010828	intermolecular recognition site; other site
395963010829	dimerization interface [polypeptide binding]; other site
395963010830	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395963010831	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395963010832	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395963010833	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395963010834	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395963010835	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
395963010836	FliP family; Region: FliP; cl00593
395963010837	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
395963010838	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
395963010839	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
395963010840	Uncharacterized conserved protein [Function unknown]; Region: COG3334
395963010841	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
395963010842	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
395963010843	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
395963010844	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
395963010845	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
395963010846	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
395963010847	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395963010848	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
395963010849	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
395963010850	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395963010851	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395963010852	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
395963010853	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
395963010854	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395963010855	catalytic Zn binding site [ion binding]; other site
395963010856	structural Zn binding site [ion binding]; other site
395963010857	NAD(P) binding site [chemical binding]; other site
395963010858	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
395963010859	active site
395963010860	8-oxo-dGMP binding site [chemical binding]; other site
395963010861	nudix motif; other site
395963010862	metal binding site [ion binding]; metal-binding site
395963010863	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
395963010864	heterotetramer interface [polypeptide binding]; other site
395963010865	active site pocket [active]
395963010866	cleavage site
395963010867	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
395963010868	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395963010869	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395963010870	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
395963010871	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395963010872	Cu(I) binding site [ion binding]; other site
395963010873	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395963010874	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
395963010875	P-loop, Walker A motif; other site
395963010876	Base recognition motif; other site
395963010877	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395963010878	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395963010879	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395963010880	active site
395963010881	catalytic tetrad [active]
395963010882	GcrA cell cycle regulator; Region: GcrA; cl11564
395963010883	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395963010884	Permease; Region: Permease; pfam02405
395963010885	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
395963010886	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
395963010887	Walker A/P-loop; other site
395963010888	ATP binding site [chemical binding]; other site
395963010889	Q-loop/lid; other site
395963010890	ABC transporter signature motif; other site
395963010891	Walker B; other site
395963010892	D-loop; other site
395963010893	H-loop/switch region; other site
395963010894	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
395963010895	mce related protein; Region: MCE; pfam02470
395963010896	Protein of unknown function (DUF330); Region: DUF330; cl01135
395963010897	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
395963010898	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395963010899	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
395963010900	ligand binding site; other site
395963010901	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395963010902	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395963010903	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
395963010904	active site
395963010905	HIGH motif; other site
395963010906	nucleotide binding site [chemical binding]; other site
395963010907	active site
395963010908	KMSKS motif; other site
395963010909	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
395963010910	hypothetical protein; Provisional; Region: PRK10756
395963010911	CreA protein; Region: CreA; pfam05981