-- dump date 20140619_001511 -- class Genbank::misc_feature -- table misc_feature_note -- id note 866536000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 866536000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 866536000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536000004 Walker A motif; other site 866536000005 ATP binding site [chemical binding]; other site 866536000006 Walker B motif; other site 866536000007 arginine finger; other site 866536000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 866536000009 DnaA box-binding interface [nucleotide binding]; other site 866536000010 membrane ATPase/protein kinase; Provisional; Region: PRK09435 866536000011 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 866536000012 Walker A; other site 866536000013 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 866536000014 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 866536000015 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 866536000016 Cu(I) binding site [ion binding]; other site 866536000017 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 866536000018 Cytochrome c; Region: Cytochrom_C; pfam00034 866536000019 MerC mercury resistance protein; Region: MerC; pfam03203 866536000020 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 866536000021 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 866536000022 homodimer interface [polypeptide binding]; other site 866536000023 substrate-cofactor binding pocket; other site 866536000024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000025 catalytic residue [active] 866536000026 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 866536000027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536000028 FtsX-like permease family; Region: FtsX; pfam02687 866536000029 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866536000030 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866536000031 Walker A/P-loop; other site 866536000032 ATP binding site [chemical binding]; other site 866536000033 Q-loop/lid; other site 866536000034 ABC transporter signature motif; other site 866536000035 Walker B; other site 866536000036 D-loop; other site 866536000037 H-loop/switch region; other site 866536000038 Response regulator receiver domain; Region: Response_reg; pfam00072 866536000039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536000040 active site 866536000041 phosphorylation site [posttranslational modification] 866536000042 intermolecular recognition site; other site 866536000043 dimerization interface [polypeptide binding]; other site 866536000044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536000045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536000046 dimer interface [polypeptide binding]; other site 866536000047 phosphorylation site [posttranslational modification] 866536000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536000049 ATP binding site [chemical binding]; other site 866536000050 Mg2+ binding site [ion binding]; other site 866536000051 G-X-G motif; other site 866536000052 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536000053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536000054 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 866536000055 putative active site [active] 866536000056 heme pocket [chemical binding]; other site 866536000057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536000058 dimer interface [polypeptide binding]; other site 866536000059 phosphorylation site [posttranslational modification] 866536000060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536000061 ATP binding site [chemical binding]; other site 866536000062 Mg2+ binding site [ion binding]; other site 866536000063 G-X-G motif; other site 866536000064 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 866536000065 CoA binding domain; Region: CoA_binding; smart00881 866536000066 CoA-ligase; Region: Ligase_CoA; pfam00549 866536000067 tubulin beta chain; Provisional; Region: PTZ00010 866536000068 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 866536000069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536000070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536000071 ABC transporter; Region: ABC_tran_2; pfam12848 866536000072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536000073 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536000074 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536000075 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 866536000076 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 866536000077 putative metal binding site [ion binding]; other site 866536000078 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 866536000079 phosphodiesterase; Provisional; Region: PRK12704 866536000080 KH domain; Region: KH_1; pfam00013 866536000081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866536000082 Zn2+ binding site [ion binding]; other site 866536000083 Mg2+ binding site [ion binding]; other site 866536000084 Cell division protein ZapA; Region: ZapA; pfam05164 866536000085 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 866536000086 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 866536000087 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 866536000088 putative tRNA-binding site [nucleotide binding]; other site 866536000089 B3/4 domain; Region: B3_4; pfam03483 866536000090 tRNA synthetase B5 domain; Region: B5; pfam03484 866536000091 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 866536000092 dimer interface [polypeptide binding]; other site 866536000093 motif 1; other site 866536000094 motif 3; other site 866536000095 motif 2; other site 866536000096 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 866536000097 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 866536000098 hypothetical protein; Reviewed; Region: PRK00024 866536000099 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 866536000100 MPN+ (JAMM) motif; other site 866536000101 Zinc-binding site [ion binding]; other site 866536000102 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 866536000103 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 866536000104 Zn binding site [ion binding]; other site 866536000105 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 866536000106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866536000107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000108 homodimer interface [polypeptide binding]; other site 866536000109 catalytic residue [active] 866536000110 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 866536000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536000112 Walker A/P-loop; other site 866536000113 ATP binding site [chemical binding]; other site 866536000114 Q-loop/lid; other site 866536000115 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536000116 ABC transporter; Region: ABC_tran_2; pfam12848 866536000117 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536000118 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536000119 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536000120 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 866536000121 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 866536000122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536000123 active site 866536000124 phosphorylation site [posttranslational modification] 866536000125 intermolecular recognition site; other site 866536000126 dimerization interface [polypeptide binding]; other site 866536000127 LytTr DNA-binding domain; Region: LytTR; pfam04397 866536000128 Histidine kinase; Region: His_kinase; pfam06580 866536000129 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 866536000130 ATP binding site [chemical binding]; other site 866536000131 Mg2+ binding site [ion binding]; other site 866536000132 G-X-G motif; other site 866536000133 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 866536000134 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 866536000135 substrate binding site; other site 866536000136 dimer interface; other site 866536000137 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 866536000138 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 866536000139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536000140 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 866536000141 FtsX-like permease family; Region: FtsX; pfam02687 866536000142 recombinase A; Provisional; Region: recA; PRK09354 866536000143 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 866536000144 hexamer interface [polypeptide binding]; other site 866536000145 Walker A motif; other site 866536000146 ATP binding site [chemical binding]; other site 866536000147 Walker B motif; other site 866536000148 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 866536000149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866536000150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536000151 active site 866536000152 phosphorylation site [posttranslational modification] 866536000153 intermolecular recognition site; other site 866536000154 dimerization interface [polypeptide binding]; other site 866536000155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866536000156 DNA binding site [nucleotide binding] 866536000157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536000158 dimer interface [polypeptide binding]; other site 866536000159 phosphorylation site [posttranslational modification] 866536000160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536000161 ATP binding site [chemical binding]; other site 866536000162 Mg2+ binding site [ion binding]; other site 866536000163 G-X-G motif; other site 866536000164 FOG: CBS domain [General function prediction only]; Region: COG0517 866536000165 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 866536000166 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 866536000167 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 866536000168 active site 866536000169 dimer interface [polypeptide binding]; other site 866536000170 catalytic nucleophile [active] 866536000171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000172 TPR repeat; Region: TPR_11; pfam13414 866536000173 binding surface 866536000174 TPR motif; other site 866536000175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000176 binding surface 866536000177 TPR motif; other site 866536000178 TPR repeat; Region: TPR_11; pfam13414 866536000179 PspC domain; Region: PspC; cl00864 866536000180 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 866536000181 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 866536000182 Probable Catalytic site; other site 866536000183 metal-binding site 866536000184 hypothetical protein; Validated; Region: PRK00153 866536000185 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 866536000186 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 866536000187 dimer interface [polypeptide binding]; other site 866536000188 motif 1; other site 866536000189 active site 866536000190 motif 2; other site 866536000191 motif 3; other site 866536000192 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 866536000193 anticodon binding site; other site 866536000194 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 866536000195 active site 866536000196 metal binding site [ion binding]; metal-binding site 866536000197 homotetramer interface [polypeptide binding]; other site 866536000198 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536000199 active site residue [active] 866536000200 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 866536000201 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 866536000202 alpha subunit interface [polypeptide binding]; other site 866536000203 TPP binding site [chemical binding]; other site 866536000204 heterodimer interface [polypeptide binding]; other site 866536000205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866536000206 Putative addiction module component; Region: Unstab_antitox; cl09921 866536000207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000208 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536000209 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536000210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 866536000211 Histidine kinase; Region: His_kinase; pfam06580 866536000212 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536000213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536000214 active site 866536000215 phosphorylation site [posttranslational modification] 866536000216 intermolecular recognition site; other site 866536000217 dimerization interface [polypeptide binding]; other site 866536000218 LytTr DNA-binding domain; Region: LytTR; smart00850 866536000219 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 866536000220 nucleoside/Zn binding site; other site 866536000221 dimer interface [polypeptide binding]; other site 866536000222 catalytic motif [active] 866536000223 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 866536000224 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000225 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 866536000226 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536000227 N-terminal plug; other site 866536000228 ligand-binding site [chemical binding]; other site 866536000229 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 866536000230 ZIP Zinc transporter; Region: Zip; pfam02535 866536000231 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 866536000232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536000233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536000234 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 866536000235 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 866536000236 NAD(P) binding site [chemical binding]; other site 866536000237 catalytic residues [active] 866536000238 Protein of unknown function (DUF779); Region: DUF779; pfam05610 866536000239 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 866536000240 VIT family; Region: VIT1; pfam01988 866536000241 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 866536000242 Domain of unknown function DUF77; Region: DUF77; pfam01910 866536000243 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536000244 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536000245 ligand binding site [chemical binding]; other site 866536000246 glutaminase A; Region: Gln_ase; TIGR03814 866536000247 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 866536000248 Predicted transcriptional regulators [Transcription]; Region: COG1695 866536000249 Transcriptional regulator PadR-like family; Region: PadR; cl17335 866536000250 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 866536000251 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 866536000252 G1 box; other site 866536000253 putative GEF interaction site [polypeptide binding]; other site 866536000254 GTP/Mg2+ binding site [chemical binding]; other site 866536000255 Switch I region; other site 866536000256 G2 box; other site 866536000257 G3 box; other site 866536000258 Switch II region; other site 866536000259 G4 box; other site 866536000260 G5 box; other site 866536000261 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 866536000262 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 866536000263 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 866536000264 AAA domain; Region: AAA_14; pfam13173 866536000265 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536000266 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536000267 Pleckstrin homology-like domain; Region: PH-like; cl17171 866536000268 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 866536000269 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 866536000270 nudix motif; other site 866536000271 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 866536000272 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866536000273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536000274 ATP binding site [chemical binding]; other site 866536000275 putative Mg++ binding site [ion binding]; other site 866536000276 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 866536000277 Virulence protein [General function prediction only]; Region: COG3943 866536000278 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 866536000279 AAA ATPase domain; Region: AAA_15; pfam13175 866536000280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536000281 Walker A/P-loop; other site 866536000282 ATP binding site [chemical binding]; other site 866536000283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536000284 Walker B; other site 866536000285 D-loop; other site 866536000286 H-loop/switch region; other site 866536000287 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866536000288 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536000289 GxxExxY protein; Region: GxxExxY; TIGR04256 866536000290 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866536000291 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866536000292 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866536000293 isocitrate dehydrogenase; Validated; Region: PRK09222 866536000294 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 866536000295 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 866536000296 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 866536000297 substrate binding site [chemical binding]; other site 866536000298 oxyanion hole (OAH) forming residues; other site 866536000299 trimer interface [polypeptide binding]; other site 866536000300 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 866536000301 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 866536000302 trimer interface [polypeptide binding]; other site 866536000303 active site 866536000304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000305 binding surface 866536000306 Tetratricopeptide repeat; Region: TPR_16; pfam13432 866536000307 TPR motif; other site 866536000308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000309 binding surface 866536000310 TPR motif; other site 866536000311 TPR repeat; Region: TPR_11; pfam13414 866536000312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000313 binding surface 866536000314 TPR motif; other site 866536000315 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 866536000316 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 866536000317 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536000318 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 866536000319 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 866536000320 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 866536000321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866536000322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866536000323 catalytic residue [active] 866536000324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536000325 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536000326 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 866536000327 Malic enzyme, N-terminal domain; Region: malic; pfam00390 866536000328 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 866536000329 putative NAD(P) binding site [chemical binding]; other site 866536000330 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 866536000331 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 866536000332 RuvA N terminal domain; Region: RuvA_N; pfam01330 866536000333 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 866536000334 cell surface protein SprA; Region: surface_SprA; TIGR04189 866536000335 Motility related/secretion protein; Region: SprA_N; pfam14349 866536000336 Motility related/secretion protein; Region: SprA_N; pfam14349 866536000337 Motility related/secretion protein; Region: SprA_N; pfam14349 866536000338 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 866536000339 lipoyl attachment site [posttranslational modification]; other site 866536000340 Predicted integral membrane protein [Function unknown]; Region: COG5652 866536000341 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 866536000342 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536000343 hypothetical protein; Provisional; Region: PRK11820 866536000344 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 866536000345 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 866536000346 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 866536000347 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 866536000348 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536000349 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 866536000350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536000351 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 866536000352 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 866536000353 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 866536000354 active site 866536000355 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 866536000356 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536000357 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536000358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536000359 active site 866536000360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 866536000361 WxcM-like, C-terminal; Region: FdtA; pfam05523 866536000362 Uncharacterized conserved protein [Function unknown]; Region: COG1739 866536000363 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 866536000364 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 866536000365 catalytic site [active] 866536000366 putative active site [active] 866536000367 putative substrate binding site [chemical binding]; other site 866536000368 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 866536000369 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 866536000370 hydroxyglutarate oxidase; Provisional; Region: PRK11728 866536000371 Protein of unknown function (DUF962); Region: DUF962; cl01879 866536000372 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 866536000373 putative cation:proton antiport protein; Provisional; Region: PRK10669 866536000374 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 866536000375 TrkA-N domain; Region: TrkA_N; pfam02254 866536000376 TrkA-C domain; Region: TrkA_C; pfam02080 866536000377 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 866536000378 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 866536000379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536000380 putative active site [active] 866536000381 heme pocket [chemical binding]; other site 866536000382 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536000383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 866536000384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 866536000385 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 866536000386 dimerization interface [polypeptide binding]; other site 866536000387 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 866536000388 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 866536000389 NAD(P) binding site [chemical binding]; other site 866536000390 substrate binding site [chemical binding]; other site 866536000391 homotetramer interface [polypeptide binding]; other site 866536000392 active site 866536000393 homodimer interface [polypeptide binding]; other site 866536000394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 866536000395 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 866536000396 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 866536000397 homotetramer interface [polypeptide binding]; other site 866536000398 ligand binding site [chemical binding]; other site 866536000399 catalytic site [active] 866536000400 NAD binding site [chemical binding]; other site 866536000401 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 866536000402 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 866536000403 Oligomerisation domain; Region: Oligomerisation; pfam02410 866536000404 FtsH Extracellular; Region: FtsH_ext; pfam06480 866536000405 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 866536000406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536000407 Walker A motif; other site 866536000408 ATP binding site [chemical binding]; other site 866536000409 Walker B motif; other site 866536000410 arginine finger; other site 866536000411 Peptidase family M41; Region: Peptidase_M41; pfam01434 866536000412 hypothetical protein; Provisional; Region: PRK13665 866536000413 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 866536000414 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 866536000415 prolyl-tRNA synthetase; Provisional; Region: PRK08661 866536000416 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 866536000417 dimer interface [polypeptide binding]; other site 866536000418 motif 1; other site 866536000419 active site 866536000420 motif 2; other site 866536000421 motif 3; other site 866536000422 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 866536000423 anticodon binding site; other site 866536000424 zinc-binding site [ion binding]; other site 866536000425 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 866536000426 shikimate kinase; Reviewed; Region: aroK; PRK00131 866536000427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 866536000428 ADP binding site [chemical binding]; other site 866536000429 magnesium binding site [ion binding]; other site 866536000430 putative shikimate binding site; other site 866536000431 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 866536000432 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 866536000433 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 866536000434 dihydropteroate synthase; Region: DHPS; TIGR01496 866536000435 substrate binding pocket [chemical binding]; other site 866536000436 dimer interface [polypeptide binding]; other site 866536000437 inhibitor binding site; inhibition site 866536000438 Uncharacterized conserved protein [Function unknown]; Region: COG1624 866536000439 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 866536000440 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 866536000441 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 866536000442 substrate-cofactor binding pocket; other site 866536000443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000444 catalytic residue [active] 866536000445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536000446 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 866536000447 NAD(P) binding site [chemical binding]; other site 866536000448 active site 866536000449 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536000450 MULE transposase domain; Region: MULE; pfam10551 866536000451 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536000452 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536000453 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536000454 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536000455 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536000456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 866536000457 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 866536000458 active site 866536000459 ATP binding site [chemical binding]; other site 866536000460 substrate binding site [chemical binding]; other site 866536000461 activation loop (A-loop); other site 866536000462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 866536000463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536000464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536000465 Transposase; Region: HTH_Tnp_1; cl17663 866536000466 SdpI/YhfL protein family; Region: SdpI; pfam13630 866536000467 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536000468 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536000469 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536000470 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536000471 GLPGLI family protein; Region: GLPGLI; TIGR01200 866536000472 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000473 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 866536000474 putative catalytic residues [active] 866536000475 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 866536000476 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866536000477 inhibitor-cofactor binding pocket; inhibition site 866536000478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000479 catalytic residue [active] 866536000480 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 866536000481 ligand binding site [chemical binding]; other site 866536000482 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 866536000483 GMP synthase; Reviewed; Region: guaA; PRK00074 866536000484 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 866536000485 AMP/PPi binding site [chemical binding]; other site 866536000486 candidate oxyanion hole; other site 866536000487 catalytic triad [active] 866536000488 potential glutamine specificity residues [chemical binding]; other site 866536000489 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 866536000490 ATP Binding subdomain [chemical binding]; other site 866536000491 Ligand Binding sites [chemical binding]; other site 866536000492 Dimerization subdomain; other site 866536000493 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 866536000494 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536000495 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 866536000496 aldose dehydrogenase; Validated; Region: PRK06398 866536000497 classical (c) SDRs; Region: SDR_c; cd05233 866536000498 NAD(P) binding site [chemical binding]; other site 866536000499 active site 866536000500 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 866536000501 GTP cyclohydrolase I; Provisional; Region: PLN03044 866536000502 active site 866536000503 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 866536000504 active site 866536000505 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 866536000506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 866536000507 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 866536000508 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 866536000509 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 866536000510 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 866536000511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536000512 active site 866536000513 motif I; other site 866536000514 motif II; other site 866536000515 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 866536000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536000517 Coenzyme A binding pocket [chemical binding]; other site 866536000518 Predicted amidohydrolase [General function prediction only]; Region: COG0388 866536000519 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 866536000520 putative active site [active] 866536000521 catalytic triad [active] 866536000522 putative dimer interface [polypeptide binding]; other site 866536000523 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 866536000524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536000525 active site 866536000526 HIGH motif; other site 866536000527 nucleotide binding site [chemical binding]; other site 866536000528 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536000529 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 866536000530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536000531 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536000532 active site 866536000533 KMSKS motif; other site 866536000534 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 866536000535 tRNA binding surface [nucleotide binding]; other site 866536000536 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 866536000537 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 866536000538 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 866536000539 substrate binding site [chemical binding]; other site 866536000540 ATP binding site [chemical binding]; other site 866536000541 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 866536000542 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 866536000543 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 866536000544 active site 866536000545 catalytic site [active] 866536000546 metal binding site [ion binding]; metal-binding site 866536000547 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 866536000548 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866536000549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536000550 FeS/SAM binding site; other site 866536000551 TRAM domain; Region: TRAM; pfam01938 866536000552 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 866536000553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536000554 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 866536000555 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 866536000556 tetramer interface [polypeptide binding]; other site 866536000557 TPP-binding site [chemical binding]; other site 866536000558 heterodimer interface [polypeptide binding]; other site 866536000559 phosphorylation loop region [posttranslational modification] 866536000560 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 866536000561 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 866536000562 alpha subunit interface [polypeptide binding]; other site 866536000563 TPP binding site [chemical binding]; other site 866536000564 heterodimer interface [polypeptide binding]; other site 866536000565 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866536000566 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 866536000567 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 866536000568 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 866536000569 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 866536000570 ribosomal protein L33; Region: rpl33; CHL00104 866536000571 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 866536000572 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 866536000573 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866536000574 inhibitor-cofactor binding pocket; inhibition site 866536000575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000576 catalytic residue [active] 866536000577 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 866536000578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536000579 motif II; other site 866536000580 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 866536000581 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 866536000582 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536000583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536000584 catalytic residues [active] 866536000585 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 866536000586 dimer interface [polypeptide binding]; other site 866536000587 allosteric magnesium binding site [ion binding]; other site 866536000588 active site 866536000589 aspartate-rich active site metal binding site; other site 866536000590 Schiff base residues; other site 866536000591 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 866536000592 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 866536000593 nucleotide binding site [chemical binding]; other site 866536000594 NEF interaction site [polypeptide binding]; other site 866536000595 SBD interface [polypeptide binding]; other site 866536000596 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 866536000597 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 866536000598 MOSC domain; Region: MOSC; pfam03473 866536000599 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 866536000600 substrate binding site [chemical binding]; other site 866536000601 active site 866536000602 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 866536000603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866536000604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536000605 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 866536000606 Walker A/P-loop; other site 866536000607 ATP binding site [chemical binding]; other site 866536000608 Q-loop/lid; other site 866536000609 ABC transporter signature motif; other site 866536000610 Walker B; other site 866536000611 D-loop; other site 866536000612 H-loop/switch region; other site 866536000613 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 866536000614 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 866536000615 dimerization interface 3.5A [polypeptide binding]; other site 866536000616 active site 866536000617 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 866536000618 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 866536000619 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866536000620 homodimer interface [polypeptide binding]; other site 866536000621 substrate-cofactor binding pocket; other site 866536000622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536000623 catalytic residue [active] 866536000624 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 866536000625 active site 866536000626 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536000627 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536000628 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536000629 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000630 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536000631 TPR repeat; Region: TPR_11; pfam13414 866536000632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000633 binding surface 866536000634 TPR motif; other site 866536000635 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536000636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536000637 ligand binding site [chemical binding]; other site 866536000638 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 866536000639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536000640 FeS/SAM binding site; other site 866536000641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536000642 Coenzyme A binding pocket [chemical binding]; other site 866536000643 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 866536000644 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 866536000645 DNA binding site [nucleotide binding] 866536000646 active site 866536000647 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 866536000648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536000649 non-specific DNA binding site [nucleotide binding]; other site 866536000650 salt bridge; other site 866536000651 sequence-specific DNA binding site [nucleotide binding]; other site 866536000652 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 866536000653 Catalytic site [active] 866536000654 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 866536000655 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 866536000656 active site 866536000657 DNA binding site [nucleotide binding] 866536000658 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 866536000659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 866536000660 DNA-binding site [nucleotide binding]; DNA binding site 866536000661 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 866536000662 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536000663 Walker A/P-loop; other site 866536000664 ATP binding site [chemical binding]; other site 866536000665 Q-loop/lid; other site 866536000666 ABC transporter signature motif; other site 866536000667 Walker B; other site 866536000668 D-loop; other site 866536000669 H-loop/switch region; other site 866536000670 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 866536000671 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866536000672 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866536000673 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 866536000674 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 866536000675 active site 866536000676 PHP Thumb interface [polypeptide binding]; other site 866536000677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 866536000678 generic binding surface I; other site 866536000679 generic binding surface II; other site 866536000680 Transposase IS200 like; Region: Y1_Tnp; cl00848 866536000681 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 866536000682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866536000683 substrate binding pocket [chemical binding]; other site 866536000684 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 866536000685 putative active site [active] 866536000686 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 866536000687 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 866536000688 heme-binding site [chemical binding]; other site 866536000689 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 866536000690 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 866536000691 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 866536000692 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536000693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536000694 Walker A motif; other site 866536000695 ATP binding site [chemical binding]; other site 866536000696 Walker B motif; other site 866536000697 arginine finger; other site 866536000698 AAA-like domain; Region: AAA_10; pfam12846 866536000699 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 866536000700 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536000701 MULE transposase domain; Region: MULE; pfam10551 866536000702 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 866536000703 Outer membrane efflux protein; Region: OEP; pfam02321 866536000704 Outer membrane efflux protein; Region: OEP; pfam02321 866536000705 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536000706 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536000707 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536000708 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 866536000709 Nitrogen regulatory protein P-II; Region: P-II; smart00938 866536000710 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 866536000711 dimerization interface [polypeptide binding]; other site 866536000712 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 866536000713 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 866536000714 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 866536000715 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536000716 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866536000717 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000718 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536000719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536000720 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 866536000721 RteC protein; Region: RteC; pfam09357 866536000722 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 866536000723 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 866536000724 active site 866536000725 putative interdomain interaction site [polypeptide binding]; other site 866536000726 putative metal-binding site [ion binding]; other site 866536000727 putative nucleotide binding site [chemical binding]; other site 866536000728 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 866536000729 domain I; other site 866536000730 DNA binding groove [nucleotide binding] 866536000731 phosphate binding site [ion binding]; other site 866536000732 domain II; other site 866536000733 domain III; other site 866536000734 nucleotide binding site [chemical binding]; other site 866536000735 catalytic site [active] 866536000736 domain IV; other site 866536000737 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 866536000738 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 866536000739 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 866536000740 putative transposase OrfB; Reviewed; Region: PHA02517 866536000741 HTH-like domain; Region: HTH_21; pfam13276 866536000742 Integrase core domain; Region: rve; pfam00665 866536000743 Integrase core domain; Region: rve_3; pfam13683 866536000744 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 866536000745 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536000746 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536000747 RteC protein; Region: RteC; pfam09357 866536000748 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536000749 catalytic residues [active] 866536000750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536000751 putative substrate translocation pore; other site 866536000752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536000753 Sulphur transport; Region: Sulf_transp; pfam04143 866536000754 Predicted transporter component [General function prediction only]; Region: COG2391 866536000755 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 866536000756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536000757 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536000758 active site residue [active] 866536000759 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536000760 active site residue [active] 866536000761 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536000762 catalytic residues [active] 866536000763 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 866536000764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536000765 Methyltransferase domain; Region: Methyltransf_31; pfam13847 866536000766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 866536000767 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 866536000768 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 866536000769 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 866536000770 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 866536000771 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 866536000772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536000773 Walker A motif; other site 866536000774 ATP binding site [chemical binding]; other site 866536000775 Walker B motif; other site 866536000776 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 866536000777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866536000778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536000779 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 866536000780 Walker A/P-loop; other site 866536000781 ATP binding site [chemical binding]; other site 866536000782 Q-loop/lid; other site 866536000783 ABC transporter signature motif; other site 866536000784 Walker B; other site 866536000785 D-loop; other site 866536000786 H-loop/switch region; other site 866536000787 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 866536000788 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 866536000789 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 866536000790 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 866536000791 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 866536000792 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 866536000793 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 866536000794 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536000795 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 866536000796 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 866536000797 domain interfaces; other site 866536000798 active site 866536000799 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 866536000800 active site 866536000801 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 866536000802 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 866536000803 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 866536000804 NADP binding site [chemical binding]; other site 866536000805 active site 866536000806 putative substrate binding site [chemical binding]; other site 866536000807 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 866536000808 Na2 binding site [ion binding]; other site 866536000809 putative substrate binding site 1 [chemical binding]; other site 866536000810 Na binding site 1 [ion binding]; other site 866536000811 putative substrate binding site 2 [chemical binding]; other site 866536000812 Response regulator receiver domain; Region: Response_reg; pfam00072 866536000813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536000814 active site 866536000815 phosphorylation site [posttranslational modification] 866536000816 intermolecular recognition site; other site 866536000817 dimerization interface [polypeptide binding]; other site 866536000818 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536000819 galactokinase; Provisional; Region: PRK05322 866536000820 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 866536000821 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 866536000822 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 866536000823 active site 866536000824 catalytic residues [active] 866536000825 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536000826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536000827 DNA binding site [nucleotide binding] 866536000828 domain linker motif; other site 866536000829 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536000830 dimerization interface [polypeptide binding]; other site 866536000831 ligand binding site [chemical binding]; other site 866536000832 M28 Zn-Peptidases; Region: M28_like_6; cd08656 866536000833 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536000834 metal binding site [ion binding]; metal-binding site 866536000835 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 866536000836 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 866536000837 active site 866536000838 HIGH motif; other site 866536000839 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 866536000840 KMSKS motif; other site 866536000841 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 866536000842 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 866536000843 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 866536000844 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 866536000845 purine monophosphate binding site [chemical binding]; other site 866536000846 dimer interface [polypeptide binding]; other site 866536000847 putative catalytic residues [active] 866536000848 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 866536000849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 866536000850 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 866536000851 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 866536000852 active site 866536000853 substrate binding site [chemical binding]; other site 866536000854 cosubstrate binding site; other site 866536000855 catalytic site [active] 866536000856 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 866536000857 SPFH domain / Band 7 family; Region: Band_7; pfam01145 866536000858 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 866536000859 UbiA prenyltransferase family; Region: UbiA; pfam01040 866536000860 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 866536000861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536000862 ATP binding site [chemical binding]; other site 866536000863 putative Mg++ binding site [ion binding]; other site 866536000864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536000865 nucleotide binding region [chemical binding]; other site 866536000866 ATP-binding site [chemical binding]; other site 866536000867 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 866536000868 HRDC domain; Region: HRDC; pfam00570 866536000869 CsbD-like; Region: CsbD; pfam05532 866536000870 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 866536000871 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 866536000872 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 866536000873 active site 866536000874 metal binding site [ion binding]; metal-binding site 866536000875 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 866536000876 nucleotide binding site [chemical binding]; other site 866536000877 WYL domain; Region: WYL; pfam13280 866536000878 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 866536000879 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866536000880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536000881 ATP binding site [chemical binding]; other site 866536000882 putative Mg++ binding site [ion binding]; other site 866536000883 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 866536000884 nucleoside/Zn binding site; other site 866536000885 catalytic motif [active] 866536000886 dimer interface [polypeptide binding]; other site 866536000887 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 866536000888 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 866536000889 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866536000890 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536000891 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866536000892 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 866536000893 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 866536000894 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 866536000895 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866536000896 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536000897 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536000898 Integrase core domain; Region: rve; pfam00665 866536000899 Integrase core domain; Region: rve_3; pfam13683 866536000900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536000901 Transposase; Region: HTH_Tnp_1; cl17663 866536000902 Transposase; Region: HTH_Tnp_1; cl17663 866536000903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536000904 Integrase core domain; Region: rve; pfam00665 866536000905 Integrase core domain; Region: rve_3; pfam13683 866536000906 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 866536000907 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 866536000908 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 866536000909 proline aminopeptidase P II; Provisional; Region: PRK10879 866536000910 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 866536000911 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 866536000912 active site 866536000913 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536000914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536000915 dimerization interface [polypeptide binding]; other site 866536000916 putative DNA binding site [nucleotide binding]; other site 866536000917 putative Zn2+ binding site [ion binding]; other site 866536000918 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 866536000919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536000920 motif II; other site 866536000921 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 866536000922 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 866536000923 Glutamate binding site [chemical binding]; other site 866536000924 NAD binding site [chemical binding]; other site 866536000925 catalytic residues [active] 866536000926 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536000927 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 866536000928 Amidase; Region: Amidase; pfam01425 866536000929 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 866536000930 NIPSNAP; Region: NIPSNAP; pfam07978 866536000931 NIPSNAP; Region: NIPSNAP; pfam07978 866536000932 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536000933 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 866536000934 Phosphoglycerate kinase; Region: PGK; pfam00162 866536000935 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 866536000936 substrate binding site [chemical binding]; other site 866536000937 hinge regions; other site 866536000938 ADP binding site [chemical binding]; other site 866536000939 catalytic site [active] 866536000940 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 866536000941 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 866536000942 TPR repeat; Region: TPR_11; pfam13414 866536000943 TPR repeat; Region: TPR_11; pfam13414 866536000944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000945 TPR motif; other site 866536000946 binding surface 866536000947 TPR repeat; Region: TPR_11; pfam13414 866536000948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536000949 binding surface 866536000950 TPR motif; other site 866536000951 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 866536000952 active site 866536000953 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 866536000954 nudix motif; other site 866536000955 DEAD-like helicases superfamily; Region: DEXDc; smart00487 866536000956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536000957 ATP binding site [chemical binding]; other site 866536000958 putative Mg++ binding site [ion binding]; other site 866536000959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536000960 nucleotide binding region [chemical binding]; other site 866536000961 ATP-binding site [chemical binding]; other site 866536000962 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 866536000963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 866536000964 substrate binding site [chemical binding]; other site 866536000965 oxyanion hole (OAH) forming residues; other site 866536000966 trimer interface [polypeptide binding]; other site 866536000967 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 866536000968 Competence protein; Region: Competence; pfam03772 866536000969 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 866536000970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536000971 Coenzyme A binding pocket [chemical binding]; other site 866536000972 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 866536000973 PhoH-like protein; Region: PhoH; pfam02562 866536000974 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 866536000975 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 866536000976 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866536000977 DNA methylase; Region: N6_N4_Mtase; pfam01555 866536000978 DNA methylase; Region: N6_N4_Mtase; cl17433 866536000979 PAS domain S-box; Region: sensory_box; TIGR00229 866536000980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536000981 putative active site [active] 866536000982 heme pocket [chemical binding]; other site 866536000983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536000984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536000985 ATP binding site [chemical binding]; other site 866536000986 Mg2+ binding site [ion binding]; other site 866536000987 G-X-G motif; other site 866536000988 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866536000989 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866536000990 malate dehydrogenase; Reviewed; Region: PRK06223 866536000991 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 866536000992 dimer interface [polypeptide binding]; other site 866536000993 NAD(P) binding site [chemical binding]; other site 866536000994 tetramer (dimer of dimers) interface [polypeptide binding]; other site 866536000995 substrate binding site [chemical binding]; other site 866536000996 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536000997 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536000998 ligand binding site [chemical binding]; other site 866536000999 flexible hinge region; other site 866536001000 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 866536001001 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 866536001002 Ligand Binding Site [chemical binding]; other site 866536001003 TilS substrate C-terminal domain; Region: TilS_C; smart00977 866536001004 OstA-like protein; Region: OstA_2; pfam13100 866536001005 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536001006 Outer membrane lipoprotein; Region: YfiO; pfam13525 866536001007 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 866536001008 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 866536001009 Flavoprotein; Region: Flavoprotein; pfam02441 866536001010 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 866536001011 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 866536001012 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 866536001013 Walker A/P-loop; other site 866536001014 ATP binding site [chemical binding]; other site 866536001015 Q-loop/lid; other site 866536001016 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 866536001017 Q-loop/lid; other site 866536001018 ABC transporter signature motif; other site 866536001019 Walker B; other site 866536001020 D-loop; other site 866536001021 H-loop/switch region; other site 866536001022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536001023 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 866536001024 NAD(P) binding site [chemical binding]; other site 866536001025 active site 866536001026 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536001027 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001028 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001029 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 866536001030 putative active site [active] 866536001031 redox center [active] 866536001032 Thioredoxin; Region: Thioredoxin_4; cl17273 866536001033 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536001034 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536001035 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536001036 N-terminal plug; other site 866536001037 ligand-binding site [chemical binding]; other site 866536001038 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 866536001039 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536001040 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 866536001041 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 866536001042 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 866536001043 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 866536001044 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 866536001045 active site 866536001046 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 866536001047 tartrate dehydrogenase; Region: TTC; TIGR02089 866536001048 (R)-citramalate synthase; Provisional; Region: PRK09389 866536001049 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 866536001050 active site 866536001051 catalytic residues [active] 866536001052 metal binding site [ion binding]; metal-binding site 866536001053 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 866536001054 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 866536001055 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 866536001056 substrate binding site [chemical binding]; other site 866536001057 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 866536001058 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 866536001059 substrate binding site [chemical binding]; other site 866536001060 ligand binding site [chemical binding]; other site 866536001061 2-isopropylmalate synthase; Validated; Region: PRK00915 866536001062 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 866536001063 active site 866536001064 catalytic residues [active] 866536001065 metal binding site [ion binding]; metal-binding site 866536001066 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 866536001067 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 866536001068 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 866536001069 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 866536001070 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 866536001071 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 866536001072 putative valine binding site [chemical binding]; other site 866536001073 dimer interface [polypeptide binding]; other site 866536001074 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 866536001075 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 866536001076 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 866536001077 PYR/PP interface [polypeptide binding]; other site 866536001078 dimer interface [polypeptide binding]; other site 866536001079 TPP binding site [chemical binding]; other site 866536001080 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 866536001081 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 866536001082 TPP-binding site [chemical binding]; other site 866536001083 dimer interface [polypeptide binding]; other site 866536001084 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 866536001085 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 866536001086 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 866536001087 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 866536001088 EamA-like transporter family; Region: EamA; pfam00892 866536001089 Predicted permeases [General function prediction only]; Region: COG0795 866536001090 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 866536001091 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 866536001092 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 866536001093 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 866536001094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536001095 active site 866536001096 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 866536001097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536001098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536001099 DNA binding residues [nucleotide binding] 866536001100 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 866536001101 putative active site [active] 866536001102 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 866536001103 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 866536001104 active site 866536001105 (T/H)XGH motif; other site 866536001106 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 866536001107 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 866536001108 catalytic site [active] 866536001109 G-X2-G-X-G-K; other site 866536001110 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 866536001111 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 866536001112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536001113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536001114 DNA binding residues [nucleotide binding] 866536001115 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 866536001116 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 866536001117 putative acyl-acceptor binding pocket; other site 866536001118 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 866536001119 Part of AAA domain; Region: AAA_19; pfam13245 866536001120 Family description; Region: UvrD_C_2; pfam13538 866536001121 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 866536001122 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 866536001123 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 866536001124 hinge; other site 866536001125 active site 866536001126 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536001127 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536001128 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 866536001129 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 866536001130 metal binding site [ion binding]; metal-binding site 866536001131 dimer interface [polypeptide binding]; other site 866536001132 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 866536001133 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 866536001134 active site 866536001135 catalytic site [active] 866536001136 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 866536001137 AAA domain; Region: AAA_14; pfam13173 866536001138 DNA polymerase III subunit beta; Validated; Region: PRK05643 866536001139 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 866536001140 putative DNA binding surface [nucleotide binding]; other site 866536001141 dimer interface [polypeptide binding]; other site 866536001142 beta-clamp/clamp loader binding surface; other site 866536001143 beta-clamp/translesion DNA polymerase binding surface; other site 866536001144 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 866536001145 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 866536001146 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 866536001147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536001148 Walker A/P-loop; other site 866536001149 ATP binding site [chemical binding]; other site 866536001150 Q-loop/lid; other site 866536001151 ABC transporter signature motif; other site 866536001152 Walker B; other site 866536001153 D-loop; other site 866536001154 H-loop/switch region; other site 866536001155 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536001156 purine nucleoside phosphorylase; Provisional; Region: PRK08202 866536001157 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 866536001158 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 866536001159 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 866536001160 active site 866536001161 Family description; Region: VCBS; pfam13517 866536001162 Family description; Region: VCBS; pfam13517 866536001163 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 866536001164 Family description; Region: VCBS; pfam13517 866536001165 Family description; Region: VCBS; pfam13517 866536001166 Family description; Region: VCBS; pfam13517 866536001167 Family description; Region: VCBS; pfam13517 866536001168 Family description; Region: VCBS; pfam13517 866536001169 Family description; Region: VCBS; pfam13517 866536001170 Family description; Region: VCBS; pfam13517 866536001171 Family description; Region: VCBS; pfam13517 866536001172 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 866536001173 Family description; Region: VCBS; pfam13517 866536001174 Family description; Region: VCBS; pfam13517 866536001175 Family description; Region: VCBS; pfam13517 866536001176 Family description; Region: VCBS; pfam13517 866536001177 Family description; Region: VCBS; pfam13517 866536001178 Family description; Region: VCBS; pfam13517 866536001179 starch binding outer membrane protein SusD; Region: SusD; cl17845 866536001180 SusD family; Region: SusD; pfam07980 866536001181 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536001182 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536001183 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536001184 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536001185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001186 ATP binding site [chemical binding]; other site 866536001187 Mg2+ binding site [ion binding]; other site 866536001188 G-X-G motif; other site 866536001189 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 866536001190 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 866536001191 dimerization interface [polypeptide binding]; other site 866536001192 DPS ferroxidase diiron center [ion binding]; other site 866536001193 ion pore; other site 866536001194 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 866536001195 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 866536001196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536001197 Walker A/P-loop; other site 866536001198 ATP binding site [chemical binding]; other site 866536001199 Q-loop/lid; other site 866536001200 ABC transporter signature motif; other site 866536001201 Walker B; other site 866536001202 D-loop; other site 866536001203 H-loop/switch region; other site 866536001204 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 866536001205 chaperone protein DnaJ; Provisional; Region: PRK14289 866536001206 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 866536001207 HSP70 interaction site [polypeptide binding]; other site 866536001208 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 866536001209 substrate binding site [polypeptide binding]; other site 866536001210 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 866536001211 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 866536001212 dimer interface [polypeptide binding]; other site 866536001213 heat shock protein GrpE; Provisional; Region: PRK14140 866536001214 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 866536001215 dimer interface [polypeptide binding]; other site 866536001216 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 866536001217 GTPase CgtA; Reviewed; Region: obgE; PRK12299 866536001218 GTP1/OBG; Region: GTP1_OBG; pfam01018 866536001219 Obg GTPase; Region: Obg; cd01898 866536001220 G1 box; other site 866536001221 GTP/Mg2+ binding site [chemical binding]; other site 866536001222 Switch I region; other site 866536001223 G2 box; other site 866536001224 G3 box; other site 866536001225 Switch II region; other site 866536001226 G4 box; other site 866536001227 G5 box; other site 866536001228 adenylate kinase; Reviewed; Region: adk; PRK00279 866536001229 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 866536001230 AMP-binding site [chemical binding]; other site 866536001231 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 866536001232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536001233 active site 866536001234 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 866536001235 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536001236 metal binding site [ion binding]; metal-binding site 866536001237 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536001238 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536001239 ligand binding site [chemical binding]; other site 866536001240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536001241 active site 866536001242 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 866536001243 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 866536001244 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 866536001245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536001246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866536001247 binding surface 866536001248 TPR motif; other site 866536001249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536001250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536001251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536001252 binding surface 866536001253 TPR motif; other site 866536001254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 866536001255 Histidine kinase; Region: HisKA_2; pfam07568 866536001256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001257 ATP binding site [chemical binding]; other site 866536001258 Mg2+ binding site [ion binding]; other site 866536001259 G-X-G motif; other site 866536001260 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536001261 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536001262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536001263 active site 866536001264 phosphorylation site [posttranslational modification] 866536001265 intermolecular recognition site; other site 866536001266 dimerization interface [polypeptide binding]; other site 866536001267 LytTr DNA-binding domain; Region: LytTR; smart00850 866536001268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001269 non-specific DNA binding site [nucleotide binding]; other site 866536001270 salt bridge; other site 866536001271 sequence-specific DNA binding site [nucleotide binding]; other site 866536001272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 866536001273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001274 non-specific DNA binding site [nucleotide binding]; other site 866536001275 salt bridge; other site 866536001276 sequence-specific DNA binding site [nucleotide binding]; other site 866536001277 Helix-turn-helix; Region: HTH_3; pfam01381 866536001278 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 866536001279 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 866536001280 Uncharacterized conserved protein [Function unknown]; Region: COG0393 866536001281 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 866536001282 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 866536001283 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 866536001284 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 866536001285 Fic family protein [Function unknown]; Region: COG3177 866536001286 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 866536001287 Fic/DOC family; Region: Fic; pfam02661 866536001288 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 866536001289 Fic family protein [Function unknown]; Region: COG3177 866536001290 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 866536001291 Fic/DOC family; Region: Fic; pfam02661 866536001292 WYL domain; Region: WYL; pfam13280 866536001293 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 866536001294 nucleotide binding site [chemical binding]; other site 866536001295 Protein of unknown function DUF262; Region: DUF262; pfam03235 866536001296 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866536001297 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866536001298 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 866536001299 Dehydroquinase class II; Region: DHquinase_II; pfam01220 866536001300 active site 866536001301 trimer interface [polypeptide binding]; other site 866536001302 dimer interface [polypeptide binding]; other site 866536001303 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 866536001304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536001305 catalytic residue [active] 866536001306 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 866536001307 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 866536001308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536001309 Walker A/P-loop; other site 866536001310 ATP binding site [chemical binding]; other site 866536001311 Q-loop/lid; other site 866536001312 ABC transporter signature motif; other site 866536001313 Walker B; other site 866536001314 D-loop; other site 866536001315 H-loop/switch region; other site 866536001316 ABC transporter; Region: ABC_tran_2; pfam12848 866536001317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536001318 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 866536001319 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 866536001320 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 866536001321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866536001322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536001323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536001324 Walker A/P-loop; other site 866536001325 ATP binding site [chemical binding]; other site 866536001326 Q-loop/lid; other site 866536001327 ABC transporter signature motif; other site 866536001328 Walker B; other site 866536001329 D-loop; other site 866536001330 H-loop/switch region; other site 866536001331 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 866536001332 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 866536001333 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 866536001334 NAD binding site [chemical binding]; other site 866536001335 Phe binding site; other site 866536001336 transcription antitermination factor NusB; Region: nusB; TIGR01951 866536001337 YtxH-like protein; Region: YtxH; pfam12732 866536001338 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 866536001339 Preprotein translocase subunit; Region: YajC; pfam02699 866536001340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 866536001341 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 866536001342 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 866536001343 CoA-binding site [chemical binding]; other site 866536001344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536001345 binding surface 866536001346 TPR repeat; Region: TPR_11; pfam13414 866536001347 TPR motif; other site 866536001348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536001349 NlpC/P60 family; Region: NLPC_P60; pfam00877 866536001350 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 866536001351 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 866536001352 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 866536001353 alpha subunit interaction interface [polypeptide binding]; other site 866536001354 Walker A motif; other site 866536001355 ATP binding site [chemical binding]; other site 866536001356 Walker B motif; other site 866536001357 inhibitor binding site; inhibition site 866536001358 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 866536001359 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 866536001360 gamma subunit interface [polypeptide binding]; other site 866536001361 LBP interface [polypeptide binding]; other site 866536001362 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 866536001363 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536001364 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 866536001365 active site 866536001366 DNA binding site [nucleotide binding] 866536001367 Int/Topo IB signature motif; other site 866536001368 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 866536001369 30S subunit binding site; other site 866536001370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536001371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536001372 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536001373 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 866536001374 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 866536001375 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536001377 Walker A motif; other site 866536001378 ATP binding site [chemical binding]; other site 866536001379 Walker B motif; other site 866536001380 arginine finger; other site 866536001381 Homeodomain-like domain; Region: HTH_23; pfam13384 866536001382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536001383 Integrase core domain; Region: rve; pfam00665 866536001384 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001385 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536001387 Walker A motif; other site 866536001388 ATP binding site [chemical binding]; other site 866536001389 Walker B motif; other site 866536001390 arginine finger; other site 866536001391 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536001392 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 866536001393 Chromate transporter; Region: Chromate_transp; pfam02417 866536001394 Chromate transporter; Region: Chromate_transp; pfam02417 866536001395 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 866536001396 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 866536001397 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 866536001398 seryl-tRNA synthetase; Provisional; Region: PRK05431 866536001399 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 866536001400 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 866536001401 dimer interface [polypeptide binding]; other site 866536001402 active site 866536001403 motif 1; other site 866536001404 motif 2; other site 866536001405 motif 3; other site 866536001406 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 866536001407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866536001408 RNA binding surface [nucleotide binding]; other site 866536001409 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 866536001410 active site 866536001411 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 866536001412 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 866536001413 putative active site [active] 866536001414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 866536001415 nucleotide binding site [chemical binding]; other site 866536001416 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 866536001417 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 866536001418 putative active site [active] 866536001419 putative metal binding site [ion binding]; other site 866536001420 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 866536001421 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536001422 catalytic loop [active] 866536001423 iron binding site [ion binding]; other site 866536001424 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 866536001425 FAD binding pocket [chemical binding]; other site 866536001426 FAD binding motif [chemical binding]; other site 866536001427 phosphate binding motif [ion binding]; other site 866536001428 beta-alpha-beta structure motif; other site 866536001429 NAD binding pocket [chemical binding]; other site 866536001430 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 866536001431 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 866536001432 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 866536001433 Carbon starvation protein CstA; Region: CstA; pfam02554 866536001434 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 866536001435 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 866536001436 translation initiation factor IF-2; Region: IF-2; TIGR00487 866536001437 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 866536001438 G1 box; other site 866536001439 putative GEF interaction site [polypeptide binding]; other site 866536001440 GTP/Mg2+ binding site [chemical binding]; other site 866536001441 Switch I region; other site 866536001442 G2 box; other site 866536001443 G3 box; other site 866536001444 Switch II region; other site 866536001445 G4 box; other site 866536001446 G5 box; other site 866536001447 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 866536001448 Translation-initiation factor 2; Region: IF-2; pfam11987 866536001449 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 866536001450 transcription termination factor NusA; Region: NusA; TIGR01953 866536001451 NusA N-terminal domain; Region: NusA_N; pfam08529 866536001452 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 866536001453 RNA binding site [nucleotide binding]; other site 866536001454 homodimer interface [polypeptide binding]; other site 866536001455 NusA-like KH domain; Region: KH_5; pfam13184 866536001456 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 866536001457 G-X-X-G motif; other site 866536001458 Sm and related proteins; Region: Sm_like; cl00259 866536001459 ribosome maturation protein RimP; Reviewed; Region: PRK00092 866536001460 Sm1 motif; other site 866536001461 rod shape-determining protein MreB; Provisional; Region: PRK13927 866536001462 MreB and similar proteins; Region: MreB_like; cd10225 866536001463 nucleotide binding site [chemical binding]; other site 866536001464 Mg binding site [ion binding]; other site 866536001465 putative protofilament interaction site [polypeptide binding]; other site 866536001466 RodZ interaction site [polypeptide binding]; other site 866536001467 rod shape-determining protein MreC; Provisional; Region: PRK13922 866536001468 rod shape-determining protein MreC; Region: MreC; pfam04085 866536001469 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 866536001470 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 866536001471 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 866536001472 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 866536001473 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536001474 active site 866536001475 Zn binding site [ion binding]; other site 866536001476 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 866536001477 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 866536001478 catalytic loop [active] 866536001479 iron binding site [ion binding]; other site 866536001480 thymidine kinase; Provisional; Region: PRK04296 866536001481 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536001482 Recombination protein O N terminal; Region: RecO_N; pfam11967 866536001483 Recombination protein O C terminal; Region: RecO_C; pfam02565 866536001484 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 866536001485 transcription termination factor Rho; Provisional; Region: PRK12608 866536001486 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 866536001487 RNA binding site [nucleotide binding]; other site 866536001488 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 866536001489 multimer interface [polypeptide binding]; other site 866536001490 Walker A motif; other site 866536001491 ATP binding site [chemical binding]; other site 866536001492 Walker B motif; other site 866536001493 Domain of unknown function DUF11; Region: DUF11; pfam01345 866536001494 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536001495 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536001496 MULE transposase domain; Region: MULE; pfam10551 866536001497 putative transposase OrfB; Reviewed; Region: PHA02517 866536001498 HTH-like domain; Region: HTH_21; pfam13276 866536001499 Integrase core domain; Region: rve; pfam00665 866536001500 Integrase core domain; Region: rve_3; pfam13683 866536001501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001502 non-specific DNA binding site [nucleotide binding]; other site 866536001503 salt bridge; other site 866536001504 sequence-specific DNA binding site [nucleotide binding]; other site 866536001505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001506 non-specific DNA binding site [nucleotide binding]; other site 866536001507 salt bridge; other site 866536001508 sequence-specific DNA binding site [nucleotide binding]; other site 866536001509 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 866536001510 ADP-ribose binding site [chemical binding]; other site 866536001511 FOG: WD40 repeat [General function prediction only]; Region: COG2319 866536001512 Caspase domain; Region: Peptidase_C14; pfam00656 866536001513 Caspase domain; Region: Peptidase_C14; pfam00656 866536001514 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001515 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001516 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001517 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001518 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 866536001519 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 866536001520 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536001521 Ligand Binding Site [chemical binding]; other site 866536001522 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536001523 Ligand Binding Site [chemical binding]; other site 866536001524 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536001525 Type III pantothenate kinase; Region: Pan_kinase; cl17198 866536001526 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 866536001527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 866536001528 classical (c) SDRs; Region: SDR_c; cd05233 866536001529 NAD(P) binding site [chemical binding]; other site 866536001530 active site 866536001531 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536001532 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536001533 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536001534 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 866536001535 Fatty acid desaturase; Region: FA_desaturase; pfam00487 866536001536 putative di-iron ligands [ion binding]; other site 866536001537 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 866536001538 AAA domain; Region: AAA_28; pfam13521 866536001539 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 866536001540 lipoprotein signal peptidase; Provisional; Region: PRK14787 866536001541 lipoprotein signal peptidase; Provisional; Region: PRK14788 866536001542 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 866536001543 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536001544 active site 866536001545 HIGH motif; other site 866536001546 nucleotide binding site [chemical binding]; other site 866536001547 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 866536001548 active site 866536001549 KMSKS motif; other site 866536001550 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 866536001551 tRNA binding surface [nucleotide binding]; other site 866536001552 anticodon binding site; other site 866536001553 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 866536001554 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 866536001555 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 866536001556 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 866536001557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536001558 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 866536001559 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 866536001560 catalytic motif [active] 866536001561 Zn binding site [ion binding]; other site 866536001562 RibD C-terminal domain; Region: RibD_C; cl17279 866536001563 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 866536001564 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 866536001565 GAF domain; Region: GAF_2; pfam13185 866536001566 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 866536001567 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 866536001568 active site 866536001569 dimerization interface [polypeptide binding]; other site 866536001570 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 866536001571 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 866536001572 ATP-binding site [chemical binding]; other site 866536001573 Sugar specificity; other site 866536001574 Pyrimidine base specificity; other site 866536001575 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 866536001576 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 866536001577 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 866536001578 Protein export membrane protein; Region: SecD_SecF; pfam02355 866536001579 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001580 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001581 Transposase IS200 like; Region: Y1_Tnp; pfam01797 866536001582 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536001583 MULE transposase domain; Region: MULE; pfam10551 866536001584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 866536001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001586 ATP binding site [chemical binding]; other site 866536001587 Mg2+ binding site [ion binding]; other site 866536001588 G-X-G motif; other site 866536001589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 866536001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536001591 active site 866536001592 phosphorylation site [posttranslational modification] 866536001593 intermolecular recognition site; other site 866536001594 dimerization interface [polypeptide binding]; other site 866536001595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 866536001596 DNA binding residues [nucleotide binding] 866536001597 dimerization interface [polypeptide binding]; other site 866536001598 putative oxidoreductase; Provisional; Region: PRK11579 866536001599 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536001600 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 866536001601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001602 non-specific DNA binding site [nucleotide binding]; other site 866536001603 salt bridge; other site 866536001604 sequence-specific DNA binding site [nucleotide binding]; other site 866536001605 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 866536001606 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 866536001607 putative SAM binding site [chemical binding]; other site 866536001608 homodimer interface [polypeptide binding]; other site 866536001609 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 866536001610 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 866536001611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536001612 catalytic residue [active] 866536001613 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 866536001614 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 866536001615 active site 866536001616 substrate binding site [chemical binding]; other site 866536001617 metal binding site [ion binding]; metal-binding site 866536001618 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 866536001619 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 866536001620 homodimer interface [polypeptide binding]; other site 866536001621 metal binding site [ion binding]; metal-binding site 866536001622 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 866536001623 homodimer interface [polypeptide binding]; other site 866536001624 active site 866536001625 putative chemical substrate binding site [chemical binding]; other site 866536001626 metal binding site [ion binding]; metal-binding site 866536001627 YceI-like domain; Region: YceI; pfam04264 866536001628 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 866536001629 core domain interface [polypeptide binding]; other site 866536001630 delta subunit interface [polypeptide binding]; other site 866536001631 epsilon subunit interface [polypeptide binding]; other site 866536001632 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 866536001633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 866536001634 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 866536001635 beta subunit interaction interface [polypeptide binding]; other site 866536001636 Walker A motif; other site 866536001637 ATP binding site [chemical binding]; other site 866536001638 Walker B motif; other site 866536001639 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 866536001640 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 866536001641 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 866536001642 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 866536001643 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 866536001644 ATP synthase subunit C; Region: ATP-synt_C; cl00466 866536001645 ATP synthase A chain; Region: ATP-synt_A; cl00413 866536001646 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 866536001647 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866536001648 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536001649 ArsC family; Region: ArsC; pfam03960 866536001650 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 866536001651 Transglycosylase; Region: Transgly; pfam00912 866536001652 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 866536001653 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 866536001654 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 866536001655 GIY-YIG motif/motif A; other site 866536001656 active site 866536001657 catalytic site [active] 866536001658 putative DNA binding site [nucleotide binding]; other site 866536001659 metal binding site [ion binding]; metal-binding site 866536001660 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 866536001661 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 866536001662 DNA binding site [nucleotide binding] 866536001663 gliding motility associated protien GldN; Region: GldN; TIGR03523 866536001664 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 866536001665 GldM N-terminal domain; Region: GldM_N; pfam12081 866536001666 GldM C-terminal domain; Region: GldM_C; pfam12080 866536001667 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 866536001668 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 866536001669 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 866536001670 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 866536001671 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 866536001672 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 866536001673 active site 866536001674 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 866536001675 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536001676 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 866536001677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536001678 FeS/SAM binding site; other site 866536001679 HemN C-terminal domain; Region: HemN_C; pfam06969 866536001680 Protein of unknown function (DUF721); Region: DUF721; pfam05258 866536001681 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 866536001682 GAF domain; Region: GAF_3; pfam13492 866536001683 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 866536001684 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 866536001685 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 866536001686 anti sigma factor interaction site; other site 866536001687 regulatory phosphorylation site [posttranslational modification]; other site 866536001688 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 866536001689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 866536001690 ATP binding site [chemical binding]; other site 866536001691 Mg2+ binding site [ion binding]; other site 866536001692 G-X-G motif; other site 866536001693 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866536001694 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866536001695 SurA N-terminal domain; Region: SurA_N; pfam09312 866536001696 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866536001697 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866536001698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866536001699 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 866536001700 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536001701 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 866536001702 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 866536001703 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866536001704 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 866536001705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536001706 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 866536001707 active site 866536001708 catalytic residues [active] 866536001709 metal binding site [ion binding]; metal-binding site 866536001710 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 866536001711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536001712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536001713 DNA binding residues [nucleotide binding] 866536001714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536001715 salt bridge; other site 866536001716 non-specific DNA binding site [nucleotide binding]; other site 866536001717 sequence-specific DNA binding site [nucleotide binding]; other site 866536001718 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 866536001719 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 866536001720 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 866536001721 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 866536001722 active site 866536001723 SAM binding site [chemical binding]; other site 866536001724 homodimer interface [polypeptide binding]; other site 866536001725 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 866536001726 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 866536001727 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 866536001728 HEPN domain; Region: HEPN; pfam05168 866536001729 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 866536001730 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 866536001731 CysD dimerization site [polypeptide binding]; other site 866536001732 G1 box; other site 866536001733 putative GEF interaction site [polypeptide binding]; other site 866536001734 GTP/Mg2+ binding site [chemical binding]; other site 866536001735 Switch I region; other site 866536001736 G2 box; other site 866536001737 G3 box; other site 866536001738 Switch II region; other site 866536001739 G4 box; other site 866536001740 G5 box; other site 866536001741 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 866536001742 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 866536001743 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 866536001744 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 866536001745 Active Sites [active] 866536001746 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 866536001747 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 866536001748 Active Sites [active] 866536001749 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 866536001750 Rrf2 family protein; Region: rrf2_super; TIGR00738 866536001751 Transcriptional regulator; Region: Rrf2; pfam02082 866536001752 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 866536001753 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 866536001754 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 866536001755 Pirin-related protein [General function prediction only]; Region: COG1741 866536001756 Pirin; Region: Pirin; pfam02678 866536001757 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 866536001758 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 866536001759 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 866536001760 homodimer interface [polypeptide binding]; other site 866536001761 putative substrate binding pocket [chemical binding]; other site 866536001762 diiron center [ion binding]; other site 866536001763 Uncharacterized conserved protein [Function unknown]; Region: COG3391 866536001764 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 866536001765 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 866536001766 active site 866536001767 dimer interface [polypeptide binding]; other site 866536001768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 866536001769 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 866536001770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536001771 dimer interface [polypeptide binding]; other site 866536001772 phosphorylation site [posttranslational modification] 866536001773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001774 ATP binding site [chemical binding]; other site 866536001775 Mg2+ binding site [ion binding]; other site 866536001776 G-X-G motif; other site 866536001777 Response regulator receiver domain; Region: Response_reg; pfam00072 866536001778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536001779 active site 866536001780 phosphorylation site [posttranslational modification] 866536001781 intermolecular recognition site; other site 866536001782 dimerization interface [polypeptide binding]; other site 866536001783 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 866536001784 putative binding surface; other site 866536001785 active site 866536001786 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 866536001787 Clp amino terminal domain; Region: Clp_N; pfam02861 866536001788 Clp amino terminal domain; Region: Clp_N; pfam02861 866536001789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536001790 Walker A motif; other site 866536001791 ATP binding site [chemical binding]; other site 866536001792 Walker B motif; other site 866536001793 arginine finger; other site 866536001794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536001795 Walker A motif; other site 866536001796 ATP binding site [chemical binding]; other site 866536001797 Walker B motif; other site 866536001798 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 866536001799 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 866536001800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536001801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536001802 DNA binding residues [nucleotide binding] 866536001803 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 866536001804 hydroxyglutarate oxidase; Provisional; Region: PRK11728 866536001805 AAA domain; Region: AAA_14; pfam13173 866536001806 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536001807 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 866536001808 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 866536001809 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 866536001810 CcmE; Region: CcmE; cl00994 866536001811 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 866536001812 CcmB protein; Region: CcmB; cl17444 866536001813 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 866536001814 heat shock protein 90; Provisional; Region: PRK05218 866536001815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001816 ATP binding site [chemical binding]; other site 866536001817 Mg2+ binding site [ion binding]; other site 866536001818 G-X-G motif; other site 866536001819 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 866536001820 dimer interface [polypeptide binding]; other site 866536001821 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536001822 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 866536001823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536001824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536001825 DNA binding residues [nucleotide binding] 866536001826 Trehalose utilisation; Region: ThuA; pfam06283 866536001827 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 866536001828 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 866536001829 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 866536001830 putative NAD(P) binding site [chemical binding]; other site 866536001831 homotetramer interface [polypeptide binding]; other site 866536001832 homodimer interface [polypeptide binding]; other site 866536001833 active site 866536001834 Trehalase; Region: Trehalase; cl17346 866536001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536001836 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 866536001837 putative substrate translocation pore; other site 866536001838 SprT-like family; Region: SprT-like; pfam10263 866536001839 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 866536001840 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 866536001841 Bacterial Ig-like domain; Region: Big_5; pfam13205 866536001842 Lamin Tail Domain; Region: LTD; pfam00932 866536001843 Lamin Tail Domain; Region: LTD; pfam00932 866536001844 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 866536001845 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 866536001846 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 866536001847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536001848 S-adenosylmethionine binding site [chemical binding]; other site 866536001849 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 866536001850 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 866536001851 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 866536001852 dimer interface [polypeptide binding]; other site 866536001853 motif 1; other site 866536001854 active site 866536001855 motif 2; other site 866536001856 motif 3; other site 866536001857 16S rRNA methyltransferase B; Provisional; Region: PRK14902 866536001858 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 866536001859 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 866536001860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536001861 S-adenosylmethionine binding site [chemical binding]; other site 866536001862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866536001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536001864 active site 866536001865 phosphorylation site [posttranslational modification] 866536001866 intermolecular recognition site; other site 866536001867 dimerization interface [polypeptide binding]; other site 866536001868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866536001869 DNA binding site [nucleotide binding] 866536001870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536001871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536001872 dimer interface [polypeptide binding]; other site 866536001873 phosphorylation site [posttranslational modification] 866536001874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536001875 ATP binding site [chemical binding]; other site 866536001876 Mg2+ binding site [ion binding]; other site 866536001877 G-X-G motif; other site 866536001878 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 866536001879 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536001880 active site 866536001881 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 866536001882 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866536001883 kynureninase; Region: kynureninase; TIGR01814 866536001884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536001885 catalytic residue [active] 866536001886 hypothetical protein; Provisional; Region: PRK06753 866536001887 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 866536001888 Ribosome-binding factor A; Region: RBFA; pfam02033 866536001889 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 866536001890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536001891 FtsX-like permease family; Region: FtsX; pfam02687 866536001892 GH3 auxin-responsive promoter; Region: GH3; pfam03321 866536001893 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 866536001894 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 866536001895 Walker A/P-loop; other site 866536001896 ATP binding site [chemical binding]; other site 866536001897 Q-loop/lid; other site 866536001898 ABC transporter signature motif; other site 866536001899 Walker B; other site 866536001900 D-loop; other site 866536001901 H-loop/switch region; other site 866536001902 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 866536001903 DHH family; Region: DHH; pfam01368 866536001904 DHHA1 domain; Region: DHHA1; pfam02272 866536001905 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 866536001906 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 866536001907 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 866536001908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536001909 N-terminal plug; other site 866536001910 ligand-binding site [chemical binding]; other site 866536001911 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 866536001912 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 866536001913 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 866536001914 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 866536001915 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 866536001916 Walker A/P-loop; other site 866536001917 ATP binding site [chemical binding]; other site 866536001918 Q-loop/lid; other site 866536001919 ABC transporter signature motif; other site 866536001920 Walker B; other site 866536001921 D-loop; other site 866536001922 H-loop/switch region; other site 866536001923 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 866536001924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 866536001925 dimer interface [polypeptide binding]; other site 866536001926 putative PBP binding regions; other site 866536001927 ABC-ATPase subunit interface; other site 866536001928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 866536001929 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 866536001930 intersubunit interface [polypeptide binding]; other site 866536001931 Ion transport protein; Region: Ion_trans; pfam00520 866536001932 Ion channel; Region: Ion_trans_2; pfam07885 866536001933 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 866536001934 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 866536001935 MutS domain I; Region: MutS_I; pfam01624 866536001936 MutS domain II; Region: MutS_II; pfam05188 866536001937 MutS domain III; Region: MutS_III; pfam05192 866536001938 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 866536001939 Walker A/P-loop; other site 866536001940 ATP binding site [chemical binding]; other site 866536001941 Q-loop/lid; other site 866536001942 ABC transporter signature motif; other site 866536001943 Walker B; other site 866536001944 D-loop; other site 866536001945 H-loop/switch region; other site 866536001946 PAS fold; Region: PAS_3; pfam08447 866536001947 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 866536001948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 866536001949 DNA binding residues [nucleotide binding] 866536001950 dimerization interface [polypeptide binding]; other site 866536001951 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536001952 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536001953 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 866536001954 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 866536001955 active site clefts [active] 866536001956 zinc binding site [ion binding]; other site 866536001957 dimer interface [polypeptide binding]; other site 866536001958 DinB family; Region: DinB; cl17821 866536001959 DinB superfamily; Region: DinB_2; pfam12867 866536001960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536001961 dimerization interface [polypeptide binding]; other site 866536001962 putative DNA binding site [nucleotide binding]; other site 866536001963 putative Zn2+ binding site [ion binding]; other site 866536001964 Low molecular weight phosphatase family; Region: LMWPc; cl00105 866536001965 active site 866536001966 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 866536001967 Sodium Bile acid symporter family; Region: SBF; cl17470 866536001968 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 866536001969 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 866536001970 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536001971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536001972 active site 866536001973 phosphorylation site [posttranslational modification] 866536001974 intermolecular recognition site; other site 866536001975 dimerization interface [polypeptide binding]; other site 866536001976 LytTr DNA-binding domain; Region: LytTR; smart00850 866536001977 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536001978 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536001979 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536001980 MoxR-like ATPases [General function prediction only]; Region: COG0714 866536001981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536001982 Walker A motif; other site 866536001983 ATP binding site [chemical binding]; other site 866536001984 Walker B motif; other site 866536001985 arginine finger; other site 866536001986 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 866536001987 pseudouridine synthase; Region: TIGR00093 866536001988 active site 866536001989 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 866536001990 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 866536001991 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 866536001992 oligomeric interface; other site 866536001993 putative active site [active] 866536001994 homodimer interface [polypeptide binding]; other site 866536001995 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 866536001996 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 866536001997 generic binding surface II; other site 866536001998 ssDNA binding site; other site 866536001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536002000 ATP binding site [chemical binding]; other site 866536002001 putative Mg++ binding site [ion binding]; other site 866536002002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536002003 nucleotide binding region [chemical binding]; other site 866536002004 ATP-binding site [chemical binding]; other site 866536002005 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 866536002006 active site 866536002007 Zn binding site [ion binding]; other site 866536002008 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 866536002009 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 866536002010 metal binding site [ion binding]; metal-binding site 866536002011 dimer interface [polypeptide binding]; other site 866536002012 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 866536002013 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 866536002014 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 866536002015 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 866536002016 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 866536002017 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 866536002018 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 866536002019 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 866536002020 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 866536002021 metal binding site [ion binding]; metal-binding site 866536002022 Fatty acid desaturase; Region: FA_desaturase; pfam00487 866536002023 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 866536002024 putative di-iron ligands [ion binding]; other site 866536002025 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 866536002026 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 866536002027 active site 866536002028 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536002029 dimer interface [polypeptide binding]; other site 866536002030 substrate binding site [chemical binding]; other site 866536002031 catalytic residues [active] 866536002032 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 866536002033 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 866536002034 metal binding site [ion binding]; metal-binding site 866536002035 putative dimer interface [polypeptide binding]; other site 866536002036 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 866536002037 Amidase; Region: Amidase; pfam01425 866536002038 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 866536002039 Phosphotransferase enzyme family; Region: APH; pfam01636 866536002040 active site 866536002041 ATP binding site [chemical binding]; other site 866536002042 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 866536002043 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 866536002044 Na binding site [ion binding]; other site 866536002045 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 866536002046 DinB family; Region: DinB; cl17821 866536002047 DinB superfamily; Region: DinB_2; pfam12867 866536002048 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 866536002049 FMN binding site [chemical binding]; other site 866536002050 dimer interface [polypeptide binding]; other site 866536002051 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 866536002052 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536002053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536002054 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 866536002055 Zn binding site [ion binding]; other site 866536002056 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 866536002057 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 866536002058 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 866536002059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536002060 Ligand Binding Site [chemical binding]; other site 866536002061 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536002062 Ligand Binding Site [chemical binding]; other site 866536002063 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 866536002064 Bacterial sugar transferase; Region: Bac_transf; pfam02397 866536002065 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536002066 Methyltransferase domain; Region: Methyltransf_31; pfam13847 866536002067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002068 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 866536002069 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 866536002070 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 866536002071 active site 866536002072 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 866536002073 homodimer interface [polypeptide binding]; other site 866536002074 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 866536002075 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536002076 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536002077 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536002078 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536002079 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 866536002080 Fatty acid desaturase; Region: FA_desaturase; pfam00487 866536002081 putative di-iron ligands [ion binding]; other site 866536002082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 866536002083 LytB protein; Region: LYTB; cl00507 866536002084 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 866536002085 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 866536002086 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 866536002087 active site lid residues [active] 866536002088 substrate binding pocket [chemical binding]; other site 866536002089 catalytic residues [active] 866536002090 substrate-Mg2+ binding site; other site 866536002091 aspartate-rich region 1; other site 866536002092 aspartate-rich region 2; other site 866536002093 phytoene desaturase; Region: crtI_fam; TIGR02734 866536002094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 866536002095 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 866536002096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536002097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536002098 DNA binding residues [nucleotide binding] 866536002099 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 866536002100 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 866536002101 DNA binding residues [nucleotide binding] 866536002102 B12 binding domain; Region: B12-binding_2; pfam02607 866536002103 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 866536002104 beta-carotene hydroxylase; Region: PLN02601 866536002105 Protein of unknown function (DUF422); Region: DUF422; cl00991 866536002106 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 866536002107 TspO/MBR family; Region: TspO_MBR; pfam03073 866536002108 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 866536002109 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 866536002110 iron-sulfur cluster [ion binding]; other site 866536002111 [2Fe-2S] cluster binding site [ion binding]; other site 866536002112 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 866536002113 dimer interface [polypeptide binding]; other site 866536002114 putative tRNA-binding site [nucleotide binding]; other site 866536002115 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 866536002116 Fasciclin domain; Region: Fasciclin; pfam02469 866536002117 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536002118 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536002119 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 866536002120 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 866536002121 putative ATP binding site [chemical binding]; other site 866536002122 putative substrate interface [chemical binding]; other site 866536002123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536002124 active site 866536002125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536002126 Transposase; Region: HTH_Tnp_1; cl17663 866536002127 Integrase core domain; Region: rve; pfam00665 866536002128 Integrase core domain; Region: rve_3; pfam13683 866536002129 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536002130 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 866536002131 cofactor binding site; other site 866536002132 DNA binding site [nucleotide binding] 866536002133 substrate interaction site [chemical binding]; other site 866536002134 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 866536002135 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 866536002136 DNA binding residues [nucleotide binding] 866536002137 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536002138 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 866536002139 cofactor binding site; other site 866536002140 DNA binding site [nucleotide binding] 866536002141 substrate interaction site [chemical binding]; other site 866536002142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536002143 non-specific DNA binding site [nucleotide binding]; other site 866536002144 salt bridge; other site 866536002145 sequence-specific DNA binding site [nucleotide binding]; other site 866536002146 Fic family protein [Function unknown]; Region: COG3177 866536002147 Fic/DOC family; Region: Fic; pfam02661 866536002148 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 866536002149 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 866536002150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536002151 ATP binding site [chemical binding]; other site 866536002152 putative Mg++ binding site [ion binding]; other site 866536002153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536002154 nucleotide binding region [chemical binding]; other site 866536002155 ATP-binding site [chemical binding]; other site 866536002156 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 866536002157 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 866536002158 NAD(P) binding site [chemical binding]; other site 866536002159 hypothetical protein; Provisional; Region: PRK08201 866536002160 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 866536002161 metal binding site [ion binding]; metal-binding site 866536002162 putative dimer interface [polypeptide binding]; other site 866536002163 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 866536002164 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 866536002165 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 866536002166 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536002167 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 866536002168 Fasciclin domain; Region: Fasciclin; pfam02469 866536002169 Fasciclin domain; Region: Fasciclin; pfam02469 866536002170 Fasciclin domain; Region: Fasciclin; pfam02469 866536002171 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 866536002172 Fasciclin domain; Region: Fasciclin; pfam02469 866536002173 Fasciclin domain; Region: Fasciclin; pfam02469 866536002174 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 866536002175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536002176 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 866536002177 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 866536002178 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 866536002179 active site 866536002180 dimer interface [polypeptide binding]; other site 866536002181 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 866536002182 Ligand Binding Site [chemical binding]; other site 866536002183 Molecular Tunnel; other site 866536002184 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 866536002185 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 866536002186 minor groove reading motif; other site 866536002187 helix-hairpin-helix signature motif; other site 866536002188 substrate binding pocket [chemical binding]; other site 866536002189 active site 866536002190 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 866536002191 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 866536002192 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536002193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536002194 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 866536002195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536002196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536002197 DNA binding residues [nucleotide binding] 866536002198 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 866536002199 AIR carboxylase; Region: AIRC; pfam00731 866536002200 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 866536002201 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 866536002202 NAD binding site [chemical binding]; other site 866536002203 ATP-grasp domain; Region: ATP-grasp; pfam02222 866536002204 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 866536002205 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 866536002206 dimer interface [polypeptide binding]; other site 866536002207 active site 866536002208 heme binding site [chemical binding]; other site 866536002209 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 866536002210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002211 Walker A/P-loop; other site 866536002212 ATP binding site [chemical binding]; other site 866536002213 Q-loop/lid; other site 866536002214 ABC transporter signature motif; other site 866536002215 Walker B; other site 866536002216 D-loop; other site 866536002217 H-loop/switch region; other site 866536002218 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 866536002219 dimerization interface [polypeptide binding]; other site 866536002220 ATP binding site [chemical binding]; other site 866536002221 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 866536002222 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 866536002223 HflX GTPase family; Region: HflX; cd01878 866536002224 G1 box; other site 866536002225 GTP/Mg2+ binding site [chemical binding]; other site 866536002226 Switch I region; other site 866536002227 G2 box; other site 866536002228 G3 box; other site 866536002229 Switch II region; other site 866536002230 G4 box; other site 866536002231 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 866536002232 PHP domain; Region: PHP; pfam02811 866536002233 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 866536002234 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 866536002235 putative NADP binding site [chemical binding]; other site 866536002236 putative substrate binding site [chemical binding]; other site 866536002237 active site 866536002238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002239 binding surface 866536002240 TPR motif; other site 866536002241 TPR repeat; Region: TPR_11; pfam13414 866536002242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002243 binding surface 866536002244 TPR motif; other site 866536002245 TPR repeat; Region: TPR_11; pfam13414 866536002246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002247 binding surface 866536002248 TPR motif; other site 866536002249 TPR repeat; Region: TPR_11; pfam13414 866536002250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002251 binding surface 866536002252 TPR motif; other site 866536002253 TPR repeat; Region: TPR_11; pfam13414 866536002254 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 866536002255 Domain of unknown function (DUF368); Region: DUF368; pfam04018 866536002256 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 866536002257 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 866536002258 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 866536002259 shikimate binding site; other site 866536002260 NAD(P) binding site [chemical binding]; other site 866536002261 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866536002262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536002263 catalytic residue [active] 866536002264 Radical SAM superfamily; Region: Radical_SAM; pfam04055 866536002265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536002266 FeS/SAM binding site; other site 866536002267 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 866536002268 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 866536002269 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 866536002270 SLBB domain; Region: SLBB; pfam10531 866536002271 SLBB domain; Region: SLBB; pfam10531 866536002272 SLBB domain; Region: SLBB; pfam10531 866536002273 SLBB domain; Region: SLBB; pfam10531 866536002274 SLBB domain; Region: SLBB; pfam10531 866536002275 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 866536002276 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 866536002277 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536002278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002279 S-adenosylmethionine binding site [chemical binding]; other site 866536002280 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 866536002281 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 866536002282 Probable Catalytic site; other site 866536002283 metal-binding site 866536002284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 866536002285 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536002286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002287 S-adenosylmethionine binding site [chemical binding]; other site 866536002288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 866536002289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536002290 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 866536002291 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 866536002292 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 866536002293 trimer interface [polypeptide binding]; other site 866536002294 active site 866536002295 substrate binding site [chemical binding]; other site 866536002296 CoA binding site [chemical binding]; other site 866536002297 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002299 S-adenosylmethionine binding site [chemical binding]; other site 866536002300 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 866536002301 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 866536002302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536002303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536002304 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 866536002305 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 866536002306 homotrimer interaction site [polypeptide binding]; other site 866536002307 putative active site [active] 866536002308 fumarate hydratase; Reviewed; Region: fumC; PRK00485 866536002309 Class II fumarases; Region: Fumarase_classII; cd01362 866536002310 active site 866536002311 tetramer interface [polypeptide binding]; other site 866536002312 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 866536002313 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536002314 Response regulator receiver domain; Region: Response_reg; pfam00072 866536002315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536002316 active site 866536002317 phosphorylation site [posttranslational modification] 866536002318 intermolecular recognition site; other site 866536002319 dimerization interface [polypeptide binding]; other site 866536002320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536002321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536002322 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 866536002323 Transglycosylase; Region: Transgly; cl17702 866536002324 hypothetical protein; Provisional; Region: PRK08317 866536002325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002326 S-adenosylmethionine binding site [chemical binding]; other site 866536002327 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 866536002328 putative active site [active] 866536002329 putative catalytic site [active] 866536002330 phytoene desaturase; Region: crtI_fam; TIGR02734 866536002331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 866536002332 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536002333 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536002334 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 866536002335 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 866536002336 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 866536002337 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 866536002338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536002339 catalytic residue [active] 866536002340 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 866536002341 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 866536002342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002343 Walker A/P-loop; other site 866536002344 ATP binding site [chemical binding]; other site 866536002345 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 866536002346 putative active site [active] 866536002347 catalytic site [active] 866536002348 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 866536002349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536002350 ATP binding site [chemical binding]; other site 866536002351 putative Mg++ binding site [ion binding]; other site 866536002352 helicase superfamily c-terminal domain; Region: HELICc; smart00490 866536002353 ATP-binding site [chemical binding]; other site 866536002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536002355 ATP binding site [chemical binding]; other site 866536002356 Mg2+ binding site [ion binding]; other site 866536002357 G-X-G motif; other site 866536002358 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 866536002359 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 866536002360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002361 Walker A/P-loop; other site 866536002362 ATP binding site [chemical binding]; other site 866536002363 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 866536002364 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 866536002365 Active Sites [active] 866536002366 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 866536002367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536002368 salt bridge; other site 866536002369 non-specific DNA binding site [nucleotide binding]; other site 866536002370 sequence-specific DNA binding site [nucleotide binding]; other site 866536002371 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536002372 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536002373 catalytic residues [active] 866536002374 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536002375 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536002376 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536002377 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536002378 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536002379 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536002380 Transposase; Region: HTH_Tnp_1; cl17663 866536002381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536002382 Integrase core domain; Region: rve; pfam00665 866536002383 Integrase core domain; Region: rve_3; pfam13683 866536002384 Cupin domain; Region: Cupin_2; cl17218 866536002385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536002386 Integrase core domain; Region: rve; pfam00665 866536002387 Integrase core domain; Region: rve_3; pfam13683 866536002388 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 866536002389 DNA-binding interface [nucleotide binding]; DNA binding site 866536002390 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002391 Histidine kinase; Region: His_kinase; pfam06580 866536002392 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866536002393 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536002394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536002395 Coenzyme A binding pocket [chemical binding]; other site 866536002396 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 866536002397 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536002398 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 866536002399 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 866536002400 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 866536002401 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 866536002402 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 866536002403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536002404 ATP binding site [chemical binding]; other site 866536002405 putative Mg++ binding site [ion binding]; other site 866536002406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536002407 nucleotide binding region [chemical binding]; other site 866536002408 ATP-binding site [chemical binding]; other site 866536002409 TRCF domain; Region: TRCF; pfam03461 866536002410 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 866536002411 Subunit I/III interface [polypeptide binding]; other site 866536002412 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 866536002413 HflK protein; Region: hflK; TIGR01933 866536002414 HflC protein; Region: hflC; TIGR01932 866536002415 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 866536002416 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 866536002417 hydrophobic ligand binding site; other site 866536002418 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 866536002419 metal binding site 2 [ion binding]; metal-binding site 866536002420 putative DNA binding helix; other site 866536002421 metal binding site 1 [ion binding]; metal-binding site 866536002422 dimer interface [polypeptide binding]; other site 866536002423 structural Zn2+ binding site [ion binding]; other site 866536002424 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 866536002425 catalytic motif [active] 866536002426 Catalytic residue [active] 866536002427 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 866536002428 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 866536002429 protein binding site [polypeptide binding]; other site 866536002430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536002431 PAS fold; Region: PAS_3; pfam08447 866536002432 putative active site [active] 866536002433 heme pocket [chemical binding]; other site 866536002434 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 866536002435 GAF domain; Region: GAF_3; pfam13492 866536002436 PAS fold; Region: PAS_4; pfam08448 866536002437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536002438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536002439 dimer interface [polypeptide binding]; other site 866536002440 phosphorylation site [posttranslational modification] 866536002441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536002442 ATP binding site [chemical binding]; other site 866536002443 Mg2+ binding site [ion binding]; other site 866536002444 G-X-G motif; other site 866536002445 LemA family; Region: LemA; pfam04011 866536002446 Repair protein; Region: Repair_PSII; pfam04536 866536002447 Repair protein; Region: Repair_PSII; pfam04536 866536002448 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 866536002449 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 866536002450 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536002451 active site 866536002452 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 866536002453 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 866536002454 putative active site [active] 866536002455 putative catalytic site [active] 866536002456 putative DNA binding site [nucleotide binding]; other site 866536002457 putative phosphate binding site [ion binding]; other site 866536002458 metal binding site A [ion binding]; metal-binding site 866536002459 putative AP binding site [nucleotide binding]; other site 866536002460 putative metal binding site B [ion binding]; other site 866536002461 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 866536002462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 866536002463 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 866536002464 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 866536002465 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 866536002466 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 866536002467 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536002468 Methyltransferase domain; Region: Methyltransf_12; pfam08242 866536002469 Bacterial Ig-like domain; Region: Big_5; pfam13205 866536002470 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 866536002471 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 866536002472 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 866536002473 acyl-activating enzyme (AAE) consensus motif; other site 866536002474 putative AMP binding site [chemical binding]; other site 866536002475 putative active site [active] 866536002476 putative CoA binding site [chemical binding]; other site 866536002477 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 866536002478 MarR family; Region: MarR; pfam01047 866536002479 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 866536002480 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 866536002481 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 866536002482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 866536002483 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 866536002484 substrate binding site [chemical binding]; other site 866536002485 oxyanion hole (OAH) forming residues; other site 866536002486 trimer interface [polypeptide binding]; other site 866536002487 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 866536002488 four helix bundle protein; Region: TIGR02436 866536002489 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 866536002490 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 866536002491 dimer interface [polypeptide binding]; other site 866536002492 active site 866536002493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536002494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536002495 active site 866536002496 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 866536002497 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536002498 active site 866536002499 DNA binding site [nucleotide binding] 866536002500 Int/Topo IB signature motif; other site 866536002501 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 866536002502 active site 866536002503 catalytic triad [active] 866536002504 oxyanion hole [active] 866536002505 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 866536002506 Divergent AAA domain; Region: AAA_4; pfam04326 866536002507 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 866536002508 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 866536002509 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866536002510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536002511 ATP binding site [chemical binding]; other site 866536002512 putative Mg++ binding site [ion binding]; other site 866536002513 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866536002514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002515 S-adenosylmethionine binding site [chemical binding]; other site 866536002516 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536002517 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866536002518 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536002519 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 866536002520 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 866536002521 AAA domain; Region: AAA_21; pfam13304 866536002522 AAA domain; Region: AAA_21; pfam13304 866536002523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002524 ABC transporter signature motif; other site 866536002525 Walker B; other site 866536002526 D-loop; other site 866536002527 H-loop/switch region; other site 866536002528 TIGR02646 family protein; Region: TIGR02646 866536002529 PLD-like domain; Region: PLDc_2; pfam13091 866536002530 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 866536002531 putative active site [active] 866536002532 catalytic site [active] 866536002533 Helix-turn-helix domain; Region: HTH_18; pfam12833 866536002534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536002535 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 866536002536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536002537 NAD(P) binding site [chemical binding]; other site 866536002538 active site 866536002539 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536002540 MULE transposase domain; Region: MULE; pfam10551 866536002541 SWIM zinc finger; Region: SWIM; pfam04434 866536002542 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 866536002543 Putative transposase; Region: Y2_Tnp; pfam04986 866536002544 Predicted transcriptional regulators [Transcription]; Region: COG1733 866536002545 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 866536002546 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 866536002547 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 866536002548 NADP binding site [chemical binding]; other site 866536002549 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 866536002550 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 866536002551 putative active site [active] 866536002552 metal binding site [ion binding]; metal-binding site 866536002553 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866536002554 Protein of unknown function DUF262; Region: DUF262; pfam03235 866536002555 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866536002556 PIN domain; Region: PIN_3; pfam13470 866536002557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536002558 non-specific DNA binding site [nucleotide binding]; other site 866536002559 salt bridge; other site 866536002560 sequence-specific DNA binding site [nucleotide binding]; other site 866536002561 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 866536002562 putative hydrophobic ligand binding site [chemical binding]; other site 866536002563 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 866536002564 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 866536002565 active site 866536002566 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 866536002567 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 866536002568 putative active site [active] 866536002569 PhoH-like protein; Region: PhoH; pfam02562 866536002570 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866536002571 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536002573 active site 866536002574 phosphorylation site [posttranslational modification] 866536002575 intermolecular recognition site; other site 866536002576 dimerization interface [polypeptide binding]; other site 866536002577 LytTr DNA-binding domain; Region: LytTR; smart00850 866536002578 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 866536002579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536002580 active site 866536002581 phosphorylation site [posttranslational modification] 866536002582 intermolecular recognition site; other site 866536002583 dimerization interface [polypeptide binding]; other site 866536002584 LytTr DNA-binding domain; Region: LytTR; smart00850 866536002585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 866536002586 Histidine kinase; Region: His_kinase; pfam06580 866536002587 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 866536002588 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866536002589 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866536002590 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 866536002591 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 866536002592 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866536002593 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866536002594 catalytic residue [active] 866536002595 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 866536002596 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 866536002597 PcrB family; Region: PcrB; pfam01884 866536002598 phosphate binding site [ion binding]; other site 866536002599 Helix-turn-helix domain; Region: HTH_18; pfam12833 866536002600 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536002601 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 866536002602 FAD binding site [chemical binding]; other site 866536002603 homotetramer interface [polypeptide binding]; other site 866536002604 substrate binding pocket [chemical binding]; other site 866536002605 catalytic base [active] 866536002606 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 866536002607 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 866536002608 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 866536002609 tetramerization interface [polypeptide binding]; other site 866536002610 active site 866536002611 pantoate--beta-alanine ligase; Region: panC; TIGR00018 866536002612 Pantoate-beta-alanine ligase; Region: PanC; cd00560 866536002613 active site 866536002614 ATP-binding site [chemical binding]; other site 866536002615 pantoate-binding site; other site 866536002616 HXXH motif; other site 866536002617 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 866536002618 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 866536002619 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 866536002620 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 866536002621 glutaminase active site [active] 866536002622 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 866536002623 dimer interface [polypeptide binding]; other site 866536002624 active site 866536002625 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 866536002626 dimer interface [polypeptide binding]; other site 866536002627 active site 866536002628 RecX family; Region: RecX; pfam02631 866536002629 triosephosphate isomerase; Provisional; Region: PRK14567 866536002630 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 866536002631 substrate binding site [chemical binding]; other site 866536002632 dimer interface [polypeptide binding]; other site 866536002633 catalytic triad [active] 866536002634 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 866536002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536002636 S-adenosylmethionine binding site [chemical binding]; other site 866536002637 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 866536002638 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 866536002639 Cl- selectivity filter; other site 866536002640 Cl- binding residues [ion binding]; other site 866536002641 pore gating glutamate residue; other site 866536002642 dimer interface [polypeptide binding]; other site 866536002643 FOG: CBS domain [General function prediction only]; Region: COG0517 866536002644 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 866536002645 M28 Zn-Peptidases; Region: M28_like_2; cd05662 866536002646 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536002647 metal binding site [ion binding]; metal-binding site 866536002648 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 866536002649 RNase_H superfamily; Region: RNase_H_2; pfam13482 866536002650 Part of AAA domain; Region: AAA_19; pfam13245 866536002651 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 866536002652 AAA domain; Region: AAA_12; pfam13087 866536002653 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 866536002654 DNA-binding interface [nucleotide binding]; DNA binding site 866536002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536002656 Integrase core domain; Region: rve; pfam00665 866536002657 Integrase core domain; Region: rve_3; pfam13683 866536002658 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536002659 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536002660 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 866536002661 ligand binding site [chemical binding]; other site 866536002662 flexible hinge region; other site 866536002663 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 866536002664 substrate binding pocket [chemical binding]; other site 866536002665 substrate-Mg2+ binding site; other site 866536002666 aspartate-rich region 1; other site 866536002667 aspartate-rich region 2; other site 866536002668 RteC protein; Region: RteC; pfam09357 866536002669 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 866536002670 PQQ-like domain; Region: PQQ_2; pfam13360 866536002671 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 866536002672 PQQ-like domain; Region: PQQ_2; pfam13360 866536002673 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536002674 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536002675 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536002676 MULE transposase domain; Region: MULE; pfam10551 866536002677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536002678 Integrase core domain; Region: rve; pfam00665 866536002679 Integrase core domain; Region: rve_3; pfam13683 866536002680 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 866536002681 DNA-binding interface [nucleotide binding]; DNA binding site 866536002682 Integrase core domain; Region: rve; pfam00665 866536002683 Integrase core domain; Region: rve_3; pfam13683 866536002684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866536002685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536002686 ATP-binding site [chemical binding]; other site 866536002687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536002688 Walker A motif; other site 866536002689 ATP binding site [chemical binding]; other site 866536002690 Walker B motif; other site 866536002691 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 866536002692 Peptidase family M41; Region: Peptidase_M41; pfam01434 866536002693 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536002694 catalytic residues [active] 866536002695 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 866536002696 hypothetical protein; Provisional; Region: PRK12378 866536002697 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 866536002698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 866536002699 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536002700 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 866536002701 putative active site pocket [active] 866536002702 dimerization interface [polypeptide binding]; other site 866536002703 putative catalytic residue [active] 866536002704 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 866536002705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866536002706 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 866536002707 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 866536002708 active site 866536002709 dimer interface [polypeptide binding]; other site 866536002710 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 866536002711 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 866536002712 active site 866536002713 FMN binding site [chemical binding]; other site 866536002714 substrate binding site [chemical binding]; other site 866536002715 3Fe-4S cluster binding site [ion binding]; other site 866536002716 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 866536002717 domain interface; other site 866536002718 gliding motility-associated protein GldE; Region: GldE; TIGR03520 866536002719 Domain of unknown function DUF21; Region: DUF21; pfam01595 866536002720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 866536002721 Transporter associated domain; Region: CorC_HlyC; smart01091 866536002722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 866536002723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 866536002724 dimer interface [polypeptide binding]; other site 866536002725 ssDNA binding site [nucleotide binding]; other site 866536002726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 866536002727 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 866536002728 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 866536002729 minor groove reading motif; other site 866536002730 helix-hairpin-helix signature motif; other site 866536002731 substrate binding pocket [chemical binding]; other site 866536002732 active site 866536002733 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 866536002734 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 866536002735 DNA binding and oxoG recognition site [nucleotide binding] 866536002736 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 866536002737 IHF - DNA interface [nucleotide binding]; other site 866536002738 IHF dimer interface [polypeptide binding]; other site 866536002739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002740 TPR motif; other site 866536002741 binding surface 866536002742 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 866536002743 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 866536002744 homodimer interface [polypeptide binding]; other site 866536002745 oligonucleotide binding site [chemical binding]; other site 866536002746 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 866536002747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536002748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536002749 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536002750 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002751 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 866536002753 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 866536002754 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 866536002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 866536002756 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 866536002757 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 866536002758 Protein of unknown function, DUF608; Region: DUF608; pfam04685 866536002759 Fic family protein [Function unknown]; Region: COG3177 866536002760 Fic/DOC family; Region: Fic; pfam02661 866536002761 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 866536002762 DNA photolyase; Region: DNA_photolyase; pfam00875 866536002763 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 866536002764 HicB family; Region: HicB; pfam05534 866536002765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866536002766 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 866536002767 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 866536002768 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 866536002769 TPP-binding site; other site 866536002770 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 866536002771 PYR/PP interface [polypeptide binding]; other site 866536002772 dimer interface [polypeptide binding]; other site 866536002773 TPP binding site [chemical binding]; other site 866536002774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866536002775 ScpA/B protein; Region: ScpA_ScpB; cl00598 866536002776 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 866536002777 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 866536002778 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866536002779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536002780 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 866536002781 active site 866536002782 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536002783 dimer interface [polypeptide binding]; other site 866536002784 substrate binding site [chemical binding]; other site 866536002785 catalytic residues [active] 866536002786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536002787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536002788 putative substrate translocation pore; other site 866536002789 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536002790 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536002791 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002792 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002793 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002794 AAA domain; Region: AAA_14; pfam13173 866536002795 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536002796 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 866536002797 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 866536002798 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 866536002799 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 866536002800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536002801 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 866536002802 Walker A/P-loop; other site 866536002803 ATP binding site [chemical binding]; other site 866536002804 Q-loop/lid; other site 866536002805 ABC transporter signature motif; other site 866536002806 Walker B; other site 866536002807 D-loop; other site 866536002808 H-loop/switch region; other site 866536002809 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 866536002810 active site 866536002811 NTP binding site [chemical binding]; other site 866536002812 metal binding triad [ion binding]; metal-binding site 866536002813 antibiotic binding site [chemical binding]; other site 866536002814 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 866536002815 putative active site [active] 866536002816 Zn binding site [ion binding]; other site 866536002817 aspartate kinase III; Validated; Region: PRK09084 866536002818 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 866536002819 nucleotide binding site [chemical binding]; other site 866536002820 substrate binding site [chemical binding]; other site 866536002821 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 866536002822 dimer interface [polypeptide binding]; other site 866536002823 allosteric regulatory binding pocket; other site 866536002824 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 866536002825 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 866536002826 homopentamer interface [polypeptide binding]; other site 866536002827 active site 866536002828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536002829 binding surface 866536002830 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 866536002831 TPR motif; other site 866536002832 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 866536002833 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 866536002834 tetramer interface [polypeptide binding]; other site 866536002835 TPP-binding site [chemical binding]; other site 866536002836 heterodimer interface [polypeptide binding]; other site 866536002837 phosphorylation loop region [posttranslational modification] 866536002838 recombination protein F; Reviewed; Region: recF; PRK00064 866536002839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002840 Walker A/P-loop; other site 866536002841 ATP binding site [chemical binding]; other site 866536002842 Q-loop/lid; other site 866536002843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536002844 ABC transporter signature motif; other site 866536002845 Walker B; other site 866536002846 D-loop; other site 866536002847 Predicted membrane protein [Function unknown]; Region: COG2259 866536002848 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536002849 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536002850 catalytic residues [active] 866536002851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536002852 active site 866536002853 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 866536002854 Nitrogen regulatory protein P-II; Region: P-II; smart00938 866536002855 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 866536002856 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 866536002857 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 866536002858 dimerization interface [polypeptide binding]; other site 866536002859 active site 866536002860 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 866536002861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536002862 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 866536002863 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 866536002864 phosphoglyceromutase; Provisional; Region: PRK05434 866536002865 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 866536002866 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 866536002867 transmembrane helices; other site 866536002868 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 866536002869 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 866536002870 NAD(P) binding pocket [chemical binding]; other site 866536002871 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 866536002872 Type III pantothenate kinase; Region: Pan_kinase; cl17198 866536002873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 866536002874 Domain of unknown function DUF21; Region: DUF21; pfam01595 866536002875 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 866536002876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 866536002877 Transporter associated domain; Region: CorC_HlyC; smart01091 866536002878 SurA N-terminal domain; Region: SurA_N_3; cl07813 866536002879 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 866536002880 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 866536002881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536002882 Integrase core domain; Region: rve; pfam00665 866536002883 Integrase core domain; Region: rve_3; cl15866 866536002884 Protein of unknown function (DUF493); Region: DUF493; pfam04359 866536002885 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 866536002886 aromatic arch; other site 866536002887 DCoH dimer interaction site [polypeptide binding]; other site 866536002888 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 866536002889 DCoH tetramer interaction site [polypeptide binding]; other site 866536002890 substrate binding site [chemical binding]; other site 866536002891 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 866536002892 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 866536002893 putative SAM binding site [chemical binding]; other site 866536002894 putative homodimer interface [polypeptide binding]; other site 866536002895 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 866536002896 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 866536002897 active site 866536002898 dimerization interface [polypeptide binding]; other site 866536002899 AsmA family; Region: AsmA; pfam05170 866536002900 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 866536002901 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 866536002902 Transposase domain (DUF772); Region: DUF772; pfam05598 866536002903 Membrane transport protein; Region: Mem_trans; cl09117 866536002904 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536002905 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 866536002906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536002907 N-terminal plug; other site 866536002908 ligand-binding site [chemical binding]; other site 866536002909 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536002910 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 866536002911 active site 866536002912 catalytic triad [active] 866536002913 oxyanion hole [active] 866536002914 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 866536002915 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 866536002916 dimer interface [polypeptide binding]; other site 866536002917 active site 866536002918 glycine-pyridoxal phosphate binding site [chemical binding]; other site 866536002919 folate binding site [chemical binding]; other site 866536002920 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 866536002921 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 866536002922 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 866536002923 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 866536002924 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 866536002925 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 866536002926 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 866536002927 Tetramer interface [polypeptide binding]; other site 866536002928 active site 866536002929 FMN-binding site [chemical binding]; other site 866536002930 Oxygen tolerance; Region: BatD; pfam13584 866536002931 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 866536002932 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 866536002933 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 866536002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536002935 Walker A motif; other site 866536002936 ATP binding site [chemical binding]; other site 866536002937 Walker B motif; other site 866536002938 arginine finger; other site 866536002939 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 866536002940 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 866536002941 ApbE family; Region: ApbE; pfam02424 866536002942 ZIP Zinc transporter; Region: Zip; pfam02535 866536002943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 866536002944 Homeodomain-like domain; Region: HTH_23; pfam13384 866536002945 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 866536002946 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 866536002947 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 866536002948 Na binding site [ion binding]; other site 866536002949 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 866536002950 Na binding site [ion binding]; other site 866536002951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536002952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536002953 dimer interface [polypeptide binding]; other site 866536002954 phosphorylation site [posttranslational modification] 866536002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536002956 ATP binding site [chemical binding]; other site 866536002957 Mg2+ binding site [ion binding]; other site 866536002958 G-X-G motif; other site 866536002959 Response regulator receiver domain; Region: Response_reg; pfam00072 866536002960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536002961 active site 866536002962 phosphorylation site [posttranslational modification] 866536002963 intermolecular recognition site; other site 866536002964 dimerization interface [polypeptide binding]; other site 866536002965 acetyl-CoA synthetase; Provisional; Region: PRK00174 866536002966 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 866536002967 active site 866536002968 CoA binding site [chemical binding]; other site 866536002969 acyl-activating enzyme (AAE) consensus motif; other site 866536002970 AMP binding site [chemical binding]; other site 866536002971 acetate binding site [chemical binding]; other site 866536002972 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 866536002973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536002974 ligand binding site [chemical binding]; other site 866536002975 flexible hinge region; other site 866536002976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 866536002977 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 866536002978 metal binding triad; other site 866536002979 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 866536002980 active site 866536002981 catalytic site [active] 866536002982 substrate binding site [chemical binding]; other site 866536002983 glycyl-tRNA synthetase; Provisional; Region: PRK04173 866536002984 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 866536002985 motif 1; other site 866536002986 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 866536002987 active site 866536002988 motif 2; other site 866536002989 motif 3; other site 866536002990 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 866536002991 anticodon binding site; other site 866536002992 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 866536002993 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 866536002994 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 866536002995 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 866536002996 active site 866536002997 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536002998 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866536002999 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536003000 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536003001 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536003002 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 866536003003 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 866536003004 Fasciclin domain; Region: Fasciclin; pfam02469 866536003005 YcxB-like protein; Region: YcxB; pfam14317 866536003006 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 866536003007 metal binding site 2 [ion binding]; metal-binding site 866536003008 putative DNA binding helix; other site 866536003009 metal binding site 1 [ion binding]; metal-binding site 866536003010 dimer interface [polypeptide binding]; other site 866536003011 structural Zn2+ binding site [ion binding]; other site 866536003012 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 866536003013 active site 866536003014 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 866536003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 866536003016 Conserved TM helix; Region: TM_helix; pfam05552 866536003017 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866536003018 S-adenosylmethionine synthetase; Validated; Region: PRK05250 866536003019 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 866536003020 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 866536003021 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 866536003022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536003023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536003024 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536003025 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 866536003026 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 866536003027 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 866536003028 RimM N-terminal domain; Region: RimM; pfam01782 866536003029 PRC-barrel domain; Region: PRC; pfam05239 866536003030 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 866536003031 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 866536003032 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 866536003033 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 866536003034 HIGH motif; other site 866536003035 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 866536003036 active site 866536003037 KMSKS motif; other site 866536003038 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536003039 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 866536003040 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 866536003041 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 866536003042 EamA-like transporter family; Region: EamA; pfam00892 866536003043 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 866536003044 EamA-like transporter family; Region: EamA; pfam00892 866536003045 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 866536003046 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 866536003047 FMN binding site [chemical binding]; other site 866536003048 active site 866536003049 catalytic residues [active] 866536003050 substrate binding site [chemical binding]; other site 866536003051 CAAX protease self-immunity; Region: Abi; pfam02517 866536003052 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 866536003053 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 866536003054 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 866536003055 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 866536003056 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 866536003057 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 866536003058 NAD(P) binding site [chemical binding]; other site 866536003059 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 866536003060 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 866536003061 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536003062 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536003063 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536003064 starch binding outer membrane protein SusD; Region: SusD; cl17845 866536003065 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 866536003066 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 866536003067 active site 866536003068 Fic family protein [Function unknown]; Region: COG3177 866536003069 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 866536003070 Fic/DOC family; Region: Fic; pfam02661 866536003071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536003072 hypothetical protein; Validated; Region: PRK08116 866536003073 Walker A/P-loop; other site 866536003074 ATP binding site [chemical binding]; other site 866536003075 Helix-turn-helix domain; Region: HTH_36; pfam13730 866536003076 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536003077 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 866536003078 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536003079 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866536003080 hypothetical protein; Provisional; Region: PRK02237 866536003081 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 866536003082 metal binding site 2 [ion binding]; metal-binding site 866536003083 putative DNA binding helix; other site 866536003084 metal binding site 1 [ion binding]; metal-binding site 866536003085 dimer interface [polypeptide binding]; other site 866536003086 structural Zn2+ binding site [ion binding]; other site 866536003087 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 866536003088 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536003089 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 866536003090 Outer membrane efflux protein; Region: OEP; pfam02321 866536003091 Outer membrane efflux protein; Region: OEP; pfam02321 866536003092 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 866536003093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536003094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536003095 motif II; other site 866536003096 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536003097 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 866536003098 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 866536003099 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 866536003100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 866536003101 Multicopper oxidase; Region: Cu-oxidase; pfam00394 866536003102 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 866536003103 Methyltransferase domain; Region: Methyltransf_12; pfam08242 866536003104 SnoaL-like domain; Region: SnoaL_3; pfam13474 866536003105 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 866536003106 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 866536003107 SPFH domain / Band 7 family; Region: Band_7; pfam01145 866536003108 Divergent AAA domain; Region: AAA_4; pfam04326 866536003109 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 866536003110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536003111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536003112 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536003113 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 866536003114 Outer membrane efflux protein; Region: OEP; pfam02321 866536003115 Outer membrane efflux protein; Region: OEP; pfam02321 866536003116 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 866536003117 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 866536003118 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 866536003119 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 866536003120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536003121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536003122 peptide chain release factor 1; Provisional; Region: PRK04011 866536003123 MerT mercuric transport protein; Region: MerT; cl03578 866536003124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536003125 metal-binding site [ion binding] 866536003126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536003127 putative DNA binding site [nucleotide binding]; other site 866536003128 putative Zn2+ binding site [ion binding]; other site 866536003129 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536003130 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 866536003131 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 866536003132 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 866536003133 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 866536003134 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 866536003135 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 866536003136 4Fe-4S binding domain; Region: Fer4_6; pfam12837 866536003137 Haem-binding domain; Region: Haem_bd; pfam14376 866536003138 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 866536003139 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 866536003140 active site 866536003141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536003142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536003143 SnoaL-like domain; Region: SnoaL_3; pfam13474 866536003144 Homeodomain-like domain; Region: HTH_23; pfam13384 866536003145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536003146 Integrase core domain; Region: rve; pfam00665 866536003147 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536003148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536003149 Walker A motif; other site 866536003150 ATP binding site [chemical binding]; other site 866536003151 Walker B motif; other site 866536003152 arginine finger; other site 866536003153 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 866536003154 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 866536003155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536003156 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 866536003157 homotrimer interaction site [polypeptide binding]; other site 866536003158 putative active site [active] 866536003159 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536003160 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 866536003161 excinuclease ABC subunit B; Provisional; Region: PRK05298 866536003162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536003163 ATP binding site [chemical binding]; other site 866536003164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536003165 nucleotide binding region [chemical binding]; other site 866536003166 ATP-binding site [chemical binding]; other site 866536003167 Ultra-violet resistance protein B; Region: UvrB; pfam12344 866536003168 UvrB/uvrC motif; Region: UVR; pfam02151 866536003169 Divergent AAA domain; Region: AAA_4; pfam04326 866536003170 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 866536003171 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 866536003172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536003173 catalytic residue [active] 866536003174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866536003175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866536003176 RNA binding surface [nucleotide binding]; other site 866536003177 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866536003178 active site 866536003179 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 866536003180 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 866536003181 homodimer interface [polypeptide binding]; other site 866536003182 active site 866536003183 TDP-binding site; other site 866536003184 acceptor substrate-binding pocket; other site 866536003185 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 866536003186 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 866536003187 homotrimer interaction site [polypeptide binding]; other site 866536003188 zinc binding site [ion binding]; other site 866536003189 CDP-binding sites; other site 866536003190 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536003191 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866536003192 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536003193 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 866536003194 metal-binding site [ion binding] 866536003195 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 866536003196 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536003197 metal-binding site [ion binding] 866536003198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536003199 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866536003200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 866536003201 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 866536003202 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 866536003203 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 866536003204 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536003205 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536003206 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536003207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536003208 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536003209 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536003210 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536003211 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536003212 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536003213 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 866536003214 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 866536003215 TPP-binding site [chemical binding]; other site 866536003216 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 866536003217 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 866536003218 E3 interaction surface; other site 866536003219 lipoyl attachment site [posttranslational modification]; other site 866536003220 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 866536003221 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 866536003222 E3 interaction surface; other site 866536003223 lipoyl attachment site [posttranslational modification]; other site 866536003224 e3 binding domain; Region: E3_binding; pfam02817 866536003225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 866536003226 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 866536003227 four helix bundle protein; Region: TIGR02436 866536003228 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 866536003229 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 866536003230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536003231 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 866536003232 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536003233 threonine synthase; Validated; Region: PRK09225 866536003234 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 866536003235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536003236 catalytic residue [active] 866536003237 homoserine kinase; Provisional; Region: PRK01212 866536003238 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 866536003239 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 866536003240 putative catalytic residues [active] 866536003241 putative nucleotide binding site [chemical binding]; other site 866536003242 putative aspartate binding site [chemical binding]; other site 866536003243 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 866536003244 dimer interface [polypeptide binding]; other site 866536003245 putative threonine allosteric regulatory site; other site 866536003246 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 866536003247 putative threonine allosteric regulatory site; other site 866536003248 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 866536003249 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 866536003250 META domain; Region: META; pfam03724 866536003251 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 866536003252 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 866536003253 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 866536003254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536003255 NAD(P) binding site [chemical binding]; other site 866536003256 active site 866536003257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866536003258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866536003259 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 866536003260 DNA binding site [nucleotide binding] 866536003261 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 866536003262 active site 866536003263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536003264 non-specific DNA binding site [nucleotide binding]; other site 866536003265 salt bridge; other site 866536003266 sequence-specific DNA binding site [nucleotide binding]; other site 866536003267 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 866536003268 Na binding site [ion binding]; other site 866536003269 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 866536003270 recombination protein RecR; Reviewed; Region: recR; PRK00076 866536003271 RecR protein; Region: RecR; pfam02132 866536003272 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 866536003273 putative active site [active] 866536003274 putative metal-binding site [ion binding]; other site 866536003275 tetramer interface [polypeptide binding]; other site 866536003276 putative transposase OrfB; Reviewed; Region: PHA02517 866536003277 HTH-like domain; Region: HTH_21; pfam13276 866536003278 Integrase core domain; Region: rve; pfam00665 866536003279 Integrase core domain; Region: rve_3; pfam13683 866536003280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536003281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536003282 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536003283 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 866536003284 GIY-YIG motif/motif A; other site 866536003285 putative active site [active] 866536003286 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 866536003287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 866536003288 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 866536003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536003290 AAA domain; Region: AAA_22; pfam13401 866536003291 Walker A motif; other site 866536003292 ATP binding site [chemical binding]; other site 866536003293 Walker B motif; other site 866536003294 arginine finger; other site 866536003295 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536003296 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 866536003297 heterotetramer interface [polypeptide binding]; other site 866536003298 active site pocket [active] 866536003299 cleavage site 866536003300 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 866536003301 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 866536003302 acetylornithine aminotransferase; Provisional; Region: PRK02627 866536003303 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866536003304 inhibitor-cofactor binding pocket; inhibition site 866536003305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536003306 catalytic residue [active] 866536003307 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 866536003308 carbamate kinase; Reviewed; Region: PRK12686 866536003309 nucleotide binding site [chemical binding]; other site 866536003310 N-acetyl-L-glutamate binding site [chemical binding]; other site 866536003311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 866536003312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536003313 active site 866536003314 phosphorylation site [posttranslational modification] 866536003315 intermolecular recognition site; other site 866536003316 dimerization interface [polypeptide binding]; other site 866536003317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 866536003318 DNA binding site [nucleotide binding] 866536003319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536003320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536003321 dimer interface [polypeptide binding]; other site 866536003322 phosphorylation site [posttranslational modification] 866536003323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536003324 ATP binding site [chemical binding]; other site 866536003325 Mg2+ binding site [ion binding]; other site 866536003326 G-X-G motif; other site 866536003327 diaminopimelate decarboxylase; Region: lysA; TIGR01048 866536003328 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 866536003329 active site 866536003330 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536003331 substrate binding site [chemical binding]; other site 866536003332 catalytic residues [active] 866536003333 dimer interface [polypeptide binding]; other site 866536003334 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 866536003335 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 866536003336 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 866536003337 FOG: PKD repeat [General function prediction only]; Region: COG3291 866536003338 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 866536003339 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 866536003340 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 866536003341 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 866536003342 dimerization interface [polypeptide binding]; other site 866536003343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536003344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536003345 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536003346 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 866536003347 homodimer interface [polypeptide binding]; other site 866536003348 homotetramer interface [polypeptide binding]; other site 866536003349 active site pocket [active] 866536003350 cleavage site 866536003351 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 866536003352 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 866536003353 NAD(P) binding site [chemical binding]; other site 866536003354 catalytic residues [active] 866536003355 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 866536003356 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536003357 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536003358 ligand binding site [chemical binding]; other site 866536003359 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536003360 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536003361 ligand binding site [chemical binding]; other site 866536003362 putative peptidase; Provisional; Region: PRK11649 866536003363 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536003364 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 866536003365 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 866536003366 dimer interface [polypeptide binding]; other site 866536003367 anticodon binding site; other site 866536003368 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 866536003369 homodimer interface [polypeptide binding]; other site 866536003370 motif 1; other site 866536003371 active site 866536003372 motif 2; other site 866536003373 GAD domain; Region: GAD; pfam02938 866536003374 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 866536003375 motif 3; other site 866536003376 YhhN-like protein; Region: YhhN; pfam07947 866536003377 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536003378 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 866536003379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866536003380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536003381 catalytic residue [active] 866536003382 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 866536003383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536003384 ferrochelatase; Reviewed; Region: hemH; PRK00035 866536003385 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 866536003386 C-terminal domain interface [polypeptide binding]; other site 866536003387 active site 866536003388 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 866536003389 active site 866536003390 N-terminal domain interface [polypeptide binding]; other site 866536003391 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 866536003392 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 866536003393 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 866536003394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536003395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536003396 DNA binding residues [nucleotide binding] 866536003397 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 866536003398 4Fe-4S binding domain; Region: Fer4; cl02805 866536003399 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 866536003400 4Fe-4S binding domain; Region: Fer4; pfam00037 866536003401 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 866536003402 Cysteine-rich domain; Region: CCG; pfam02754 866536003403 Cysteine-rich domain; Region: CCG; pfam02754 866536003404 AAA domain; Region: AAA_14; pfam13173 866536003405 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536003406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536003407 binding surface 866536003408 TPR motif; other site 866536003409 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 866536003410 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536003411 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536003412 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536003413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536003414 ligand binding site [chemical binding]; other site 866536003415 Methyltransferase domain; Region: Methyltransf_31; pfam13847 866536003416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536003417 S-adenosylmethionine binding site [chemical binding]; other site 866536003418 hypothetical protein; Provisional; Region: PRK10279 866536003419 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 866536003420 active site 866536003421 nucleophile elbow; other site 866536003422 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 866536003423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536003424 putative metal binding site [ion binding]; other site 866536003425 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 866536003426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866536003427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536003428 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536003429 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536003430 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536003431 Outer membrane efflux protein; Region: OEP; pfam02321 866536003432 Outer membrane efflux protein; Region: OEP; pfam02321 866536003433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 866536003434 substrate binding pocket [chemical binding]; other site 866536003435 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 866536003436 membrane-bound complex binding site; other site 866536003437 hinge residues; other site 866536003438 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 866536003439 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866536003440 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866536003441 catalytic residue [active] 866536003442 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 866536003443 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 866536003444 MarR family; Region: MarR; pfam01047 866536003445 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 866536003446 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 866536003447 Walker A/P-loop; other site 866536003448 ATP binding site [chemical binding]; other site 866536003449 Q-loop/lid; other site 866536003450 ABC transporter signature motif; other site 866536003451 Walker B; other site 866536003452 D-loop; other site 866536003453 H-loop/switch region; other site 866536003454 TOBE domain; Region: TOBE_2; pfam08402 866536003455 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 866536003456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 866536003457 dimer interface [polypeptide binding]; other site 866536003458 conserved gate region; other site 866536003459 putative PBP binding loops; other site 866536003460 ABC-ATPase subunit interface; other site 866536003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 866536003462 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 866536003463 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 866536003464 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 866536003465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 866536003466 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 866536003467 dimerization interface [polypeptide binding]; other site 866536003468 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 866536003470 AAA domain; Region: AAA_22; pfam13401 866536003471 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 866536003472 DNA repair protein RadA; Provisional; Region: PRK11823 866536003473 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 866536003474 Walker A motif/ATP binding site; other site 866536003475 ATP binding site [chemical binding]; other site 866536003476 Walker B motif; other site 866536003477 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 866536003478 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 866536003479 active site 866536003480 NTP binding site [chemical binding]; other site 866536003481 metal binding triad [ion binding]; metal-binding site 866536003482 antibiotic binding site [chemical binding]; other site 866536003483 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 866536003484 DNA polymerase I; Provisional; Region: PRK05755 866536003485 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 866536003486 active site 866536003487 metal binding site 1 [ion binding]; metal-binding site 866536003488 putative 5' ssDNA interaction site; other site 866536003489 metal binding site 3; metal-binding site 866536003490 metal binding site 2 [ion binding]; metal-binding site 866536003491 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 866536003492 putative DNA binding site [nucleotide binding]; other site 866536003493 putative metal binding site [ion binding]; other site 866536003494 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 866536003495 active site 866536003496 catalytic site [active] 866536003497 substrate binding site [chemical binding]; other site 866536003498 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 866536003499 active site 866536003500 DNA binding site [nucleotide binding] 866536003501 catalytic site [active] 866536003502 Class I aldolases; Region: Aldolase_Class_I; cl17187 866536003503 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 866536003504 putative active site [active] 866536003505 Zn binding site [ion binding]; other site 866536003506 hypothetical protein; Provisional; Region: PRK04164 866536003507 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 866536003508 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 866536003509 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 866536003510 catalytic residues [active] 866536003511 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 866536003512 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 866536003513 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 866536003514 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 866536003515 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536003516 methionine gamma-lyase; Validated; Region: PRK07049 866536003517 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866536003518 homodimer interface [polypeptide binding]; other site 866536003519 substrate-cofactor binding pocket; other site 866536003520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536003521 catalytic residue [active] 866536003522 DNA binding domain, excisionase family; Region: excise; TIGR01764 866536003523 PIN domain; Region: PIN_3; pfam13470 866536003524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 866536003525 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 866536003526 Coenzyme A binding pocket [chemical binding]; other site 866536003527 peptide chain release factor 1; Validated; Region: prfA; PRK00591 866536003528 This domain is found in peptide chain release factors; Region: PCRF; smart00937 866536003529 RF-1 domain; Region: RF-1; pfam00472 866536003530 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 866536003531 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866536003532 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 866536003533 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 866536003534 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 866536003535 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536003536 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536003537 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536003538 catalytic residues [active] 866536003539 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536003540 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536003541 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536003542 catalytic residues [active] 866536003543 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536003544 active site 866536003545 Zn binding site [ion binding]; other site 866536003546 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536003547 active site 866536003548 Zn binding site [ion binding]; other site 866536003549 serine racemase; Region: PLN02970 866536003550 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 866536003551 tetramer interface [polypeptide binding]; other site 866536003552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536003553 catalytic residue [active] 866536003554 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536003555 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536003556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536003557 Integrase core domain; Region: rve; pfam00665 866536003558 Integrase core domain; Region: rve_3; pfam13683 866536003559 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 866536003560 DNA-binding interface [nucleotide binding]; DNA binding site 866536003561 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 866536003562 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 866536003563 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 866536003564 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866536003565 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866536003566 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 866536003567 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536003568 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 866536003569 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 866536003570 catalytic residue [active] 866536003571 putative FPP diphosphate binding site; other site 866536003572 putative FPP binding hydrophobic cleft; other site 866536003573 dimer interface [polypeptide binding]; other site 866536003574 putative IPP diphosphate binding site; other site 866536003575 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 866536003576 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 866536003577 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 866536003578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 866536003579 FOG: CBS domain [General function prediction only]; Region: COG0517 866536003580 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 866536003581 Glutamine amidotransferase class-I; Region: GATase; pfam00117 866536003582 glutamine binding [chemical binding]; other site 866536003583 catalytic triad [active] 866536003584 Colicin V production protein; Region: Colicin_V; pfam02674 866536003585 Yqey-like protein; Region: YqeY; cl17540 866536003586 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 866536003587 active site 866536003588 hydrophilic channel; other site 866536003589 dimerization interface [polypeptide binding]; other site 866536003590 catalytic residues [active] 866536003591 active site lid [active] 866536003592 acyl-CoA esterase; Provisional; Region: PRK10673 866536003593 PGAP1-like protein; Region: PGAP1; pfam07819 866536003594 Predicted membrane protein [Function unknown]; Region: COG2860 866536003595 UPF0126 domain; Region: UPF0126; pfam03458 866536003596 UPF0126 domain; Region: UPF0126; pfam03458 866536003597 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 866536003598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 866536003599 metal ion-dependent adhesion site (MIDAS); other site 866536003600 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 866536003601 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 866536003602 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 866536003603 active site 866536003604 multimer interface [polypeptide binding]; other site 866536003605 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 866536003606 DHH family; Region: DHH; pfam01368 866536003607 DHHA1 domain; Region: DHHA1; pfam02272 866536003608 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536003609 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 866536003610 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536003611 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536003612 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 866536003613 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 866536003614 active site 866536003615 ligand binding site [chemical binding]; other site 866536003616 NAD(P) binding site [chemical binding]; other site 866536003617 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 866536003618 intersubunit interface [polypeptide binding]; other site 866536003619 active site 866536003620 catalytic residue [active] 866536003621 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 866536003622 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 866536003623 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 866536003624 nucleoside/Zn binding site; other site 866536003625 dimer interface [polypeptide binding]; other site 866536003626 catalytic motif [active] 866536003627 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 866536003628 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 866536003629 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 866536003630 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 866536003631 active site 866536003632 catalytic triad [active] 866536003633 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536003634 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 866536003635 putative active site [active] 866536003636 Zn binding site [ion binding]; other site 866536003637 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 866536003638 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 866536003639 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 866536003640 TIGR01777 family protein; Region: yfcH 866536003641 putative NAD(P) binding site [chemical binding]; other site 866536003642 putative active site [active] 866536003643 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 866536003644 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 866536003645 putative Cl- selectivity filter; other site 866536003646 putative pore gating glutamate residue; other site 866536003647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536003648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536003649 putative substrate translocation pore; other site 866536003650 Methyltransferase domain; Region: Methyltransf_23; pfam13489 866536003651 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 866536003652 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 866536003653 Sulfate transporter family; Region: Sulfate_transp; pfam00916 866536003654 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 866536003655 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 866536003656 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536003657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 866536003658 active site 866536003659 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 866536003660 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 866536003661 active site 866536003662 Int/Topo IB signature motif; other site 866536003663 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 866536003664 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 866536003665 quinone interaction residues [chemical binding]; other site 866536003666 active site 866536003667 catalytic residues [active] 866536003668 FMN binding site [chemical binding]; other site 866536003669 substrate binding site [chemical binding]; other site 866536003670 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 866536003671 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 866536003672 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 866536003673 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 866536003674 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 866536003675 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 866536003676 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 866536003677 active site 866536003678 dimer interface [polypeptide binding]; other site 866536003679 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 866536003680 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 866536003681 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 866536003682 putative trimer interface [polypeptide binding]; other site 866536003683 putative CoA binding site [chemical binding]; other site 866536003684 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 866536003685 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 866536003686 active site residue [active] 866536003687 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 866536003688 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 866536003689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 866536003690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536003691 active site 866536003692 phosphorylation site [posttranslational modification] 866536003693 intermolecular recognition site; other site 866536003694 dimerization interface [polypeptide binding]; other site 866536003695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 866536003696 DNA binding residues [nucleotide binding] 866536003697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 866536003698 Histidine kinase; Region: HisKA_3; pfam07730 866536003699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536003700 ATP binding site [chemical binding]; other site 866536003701 Mg2+ binding site [ion binding]; other site 866536003702 G-X-G motif; other site 866536003703 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536003704 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536003705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536003706 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 866536003707 RNA/DNA hybrid binding site [nucleotide binding]; other site 866536003708 active site 866536003709 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 866536003710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536003711 S-adenosylmethionine binding site [chemical binding]; other site 866536003712 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 866536003713 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536003714 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 866536003715 active site 866536003716 catalytic motif [active] 866536003717 Zn binding site [ion binding]; other site 866536003718 Serine hydrolase (FSH1); Region: FSH1; pfam03959 866536003719 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536003720 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 866536003721 lipoyl synthase; Provisional; Region: PRK05481 866536003722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536003723 FeS/SAM binding site; other site 866536003724 OsmC-like protein; Region: OsmC; pfam02566 866536003725 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 866536003726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536003727 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536003728 DNA binding residues [nucleotide binding] 866536003729 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536003730 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536003731 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 866536003732 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 866536003733 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 866536003734 GTPase Era; Reviewed; Region: era; PRK00089 866536003735 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 866536003736 G1 box; other site 866536003737 GTP/Mg2+ binding site [chemical binding]; other site 866536003738 Switch I region; other site 866536003739 G2 box; other site 866536003740 Switch II region; other site 866536003741 G3 box; other site 866536003742 G4 box; other site 866536003743 G5 box; other site 866536003744 KH domain; Region: KH_2; pfam07650 866536003745 GTP-binding protein Der; Reviewed; Region: PRK00093 866536003746 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 866536003747 G1 box; other site 866536003748 GTP/Mg2+ binding site [chemical binding]; other site 866536003749 Switch I region; other site 866536003750 G2 box; other site 866536003751 Switch II region; other site 866536003752 G3 box; other site 866536003753 G4 box; other site 866536003754 G5 box; other site 866536003755 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 866536003756 G1 box; other site 866536003757 GTP/Mg2+ binding site [chemical binding]; other site 866536003758 Switch I region; other site 866536003759 G2 box; other site 866536003760 G3 box; other site 866536003761 Switch II region; other site 866536003762 G4 box; other site 866536003763 G5 box; other site 866536003764 glycine dehydrogenase; Provisional; Region: PRK05367 866536003765 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 866536003766 tetramer interface [polypeptide binding]; other site 866536003767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536003768 catalytic residue [active] 866536003769 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 866536003770 tetramer interface [polypeptide binding]; other site 866536003771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536003772 catalytic residue [active] 866536003773 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536003774 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 866536003775 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536003776 metal binding site [ion binding]; metal-binding site 866536003777 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536003778 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866536003779 DEAD-like helicases superfamily; Region: DEXDc; smart00487 866536003780 ATP binding site [chemical binding]; other site 866536003781 Mg++ binding site [ion binding]; other site 866536003782 motif III; other site 866536003783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536003784 nucleotide binding region [chemical binding]; other site 866536003785 ATP-binding site [chemical binding]; other site 866536003786 dihydroorotase; Reviewed; Region: PRK09236 866536003787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536003788 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 866536003789 active site 866536003790 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 866536003791 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 866536003792 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 866536003793 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 866536003794 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 866536003795 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 866536003796 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 866536003797 putative active site [active] 866536003798 catalytic site [active] 866536003799 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 866536003800 homotrimer interaction site [polypeptide binding]; other site 866536003801 putative active site [active] 866536003802 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536003803 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536003804 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536003805 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536003807 Walker A motif; other site 866536003808 ATP binding site [chemical binding]; other site 866536003809 Walker B motif; other site 866536003810 arginine finger; other site 866536003811 Homeodomain-like domain; Region: HTH_23; pfam13384 866536003812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536003813 Integrase core domain; Region: rve; pfam00665 866536003814 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536003815 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536003816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536003817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536003818 dimer interface [polypeptide binding]; other site 866536003819 phosphorylation site [posttranslational modification] 866536003820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536003821 ATP binding site [chemical binding]; other site 866536003822 Mg2+ binding site [ion binding]; other site 866536003823 G-X-G motif; other site 866536003824 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536003825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536003826 active site 866536003827 phosphorylation site [posttranslational modification] 866536003828 intermolecular recognition site; other site 866536003829 dimerization interface [polypeptide binding]; other site 866536003830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536003831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536003832 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 866536003833 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536003834 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536003835 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536003836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536003837 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536003838 SusE outer membrane protein; Region: SusE; pfam14292 866536003839 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 866536003840 starch binding site [chemical binding]; other site 866536003841 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 866536003842 starch binding site [chemical binding]; other site 866536003843 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536003844 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536003845 Winged helix-turn helix; Region: HTH_29; pfam13551 866536003846 Homeodomain-like domain; Region: HTH_23; pfam13384 866536003847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536003848 Integrase core domain; Region: rve; pfam00665 866536003849 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536003850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536003851 Walker A motif; other site 866536003852 ATP binding site [chemical binding]; other site 866536003853 Walker B motif; other site 866536003854 arginine finger; other site 866536003855 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 866536003856 catalytic residue [active] 866536003857 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 866536003858 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 866536003859 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866536003860 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536003861 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866536003862 potential frameshift: common BLAST hit: gi|313675686|ref|YP_004053682.1| fg-gap repeat protein 866536003863 Family description; Region: VCBS; pfam13517 866536003864 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536003865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 866536003866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536003867 active site 866536003868 phosphorylation site [posttranslational modification] 866536003869 intermolecular recognition site; other site 866536003870 dimerization interface [polypeptide binding]; other site 866536003871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 866536003872 DNA binding residues [nucleotide binding] 866536003873 dimerization interface [polypeptide binding]; other site 866536003874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536003875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866536003876 binding surface 866536003877 TPR motif; other site 866536003878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536003879 binding surface 866536003880 TPR motif; other site 866536003881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536003882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536003883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536003884 binding surface 866536003885 TPR motif; other site 866536003886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 866536003887 Histidine kinase; Region: HisKA_3; pfam07730 866536003888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536003889 ATP binding site [chemical binding]; other site 866536003890 Mg2+ binding site [ion binding]; other site 866536003891 G-X-G motif; other site 866536003892 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 866536003893 oligomerization interface [polypeptide binding]; other site 866536003894 active site 866536003895 metal binding site [ion binding]; metal-binding site 866536003896 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 866536003897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536003898 active site 866536003899 GTPase RsgA; Reviewed; Region: PRK00098 866536003900 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 866536003901 RNA binding site [nucleotide binding]; other site 866536003902 homodimer interface [polypeptide binding]; other site 866536003903 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 866536003904 GTPase/Zn-binding domain interface [polypeptide binding]; other site 866536003905 GTP/Mg2+ binding site [chemical binding]; other site 866536003906 G4 box; other site 866536003907 G5 box; other site 866536003908 G1 box; other site 866536003909 Switch I region; other site 866536003910 G2 box; other site 866536003911 G3 box; other site 866536003912 Switch II region; other site 866536003913 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 866536003914 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 866536003915 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 866536003916 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 866536003917 dimer interface [polypeptide binding]; other site 866536003918 decamer (pentamer of dimers) interface [polypeptide binding]; other site 866536003919 catalytic triad [active] 866536003920 peroxidatic and resolving cysteines [active] 866536003921 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 866536003922 Low molecular weight phosphatase family; Region: LMWPc; cd00115 866536003923 active site 866536003924 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 866536003925 Phosphotransferase enzyme family; Region: APH; pfam01636 866536003926 active site 866536003927 ATP binding site [chemical binding]; other site 866536003928 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 866536003929 substrate binding site [chemical binding]; other site 866536003930 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 866536003931 nucleotide binding site [chemical binding]; other site 866536003932 substrate binding site [chemical binding]; other site 866536003933 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 866536003934 AMP binding site [chemical binding]; other site 866536003935 metal binding site [ion binding]; metal-binding site 866536003936 active site 866536003937 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 866536003938 G1 box; other site 866536003939 GTP/Mg2+ binding site [chemical binding]; other site 866536003940 Switch I region; other site 866536003941 G2 box; other site 866536003942 G3 box; other site 866536003943 Switch II region; other site 866536003944 G4 box; other site 866536003945 G5 box; other site 866536003946 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 866536003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536003948 S-adenosylmethionine binding site [chemical binding]; other site 866536003949 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536003950 Uncharacterized conserved protein [Function unknown]; Region: COG4850 866536003951 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 866536003952 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 866536003953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536003954 FeS/SAM binding site; other site 866536003955 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 866536003956 Rhomboid family; Region: Rhomboid; pfam01694 866536003957 Rhomboid family; Region: Rhomboid; pfam01694 866536003958 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 866536003959 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 866536003960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536003961 ATP binding site [chemical binding]; other site 866536003962 Mg2+ binding site [ion binding]; other site 866536003963 G-X-G motif; other site 866536003964 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 866536003965 ATP binding site [chemical binding]; other site 866536003966 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 866536003967 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 866536003968 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 866536003969 Beta-lactamase; Region: Beta-lactamase; cl17358 866536003970 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 866536003971 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 866536003972 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 866536003973 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 866536003974 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 866536003975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536003976 NAD(P) binding site [chemical binding]; other site 866536003977 active site 866536003978 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 866536003979 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 866536003980 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 866536003981 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 866536003982 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 866536003983 Penicillinase repressor; Region: Pencillinase_R; pfam03965 866536003984 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 866536003985 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 866536003986 FMN binding site [chemical binding]; other site 866536003987 active site 866536003988 substrate binding site [chemical binding]; other site 866536003989 catalytic residue [active] 866536003990 NRDE protein; Region: NRDE; cl01315 866536003991 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 866536003992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 866536003993 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 866536003994 amino acid transporter; Region: 2A0306; TIGR00909 866536003995 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 866536003996 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 866536003997 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 866536003998 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 866536003999 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 866536004000 putative acyl-acceptor binding pocket; other site 866536004001 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 866536004002 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 866536004003 substrate binding pocket [chemical binding]; other site 866536004004 chain length determination region; other site 866536004005 substrate-Mg2+ binding site; other site 866536004006 catalytic residues [active] 866536004007 aspartate-rich region 1; other site 866536004008 active site lid residues [active] 866536004009 aspartate-rich region 2; other site 866536004010 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536004011 MG2 domain; Region: A2M_N; pfam01835 866536004012 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536004013 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536004014 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536004015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536004016 catalytic residues [active] 866536004017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 866536004018 MraZ protein; Region: MraZ; pfam02381 866536004019 MraZ protein; Region: MraZ; pfam02381 866536004020 MraW methylase family; Region: Methyltransf_5; cl17771 866536004021 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 866536004022 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 866536004023 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 866536004024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 866536004025 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 866536004026 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 866536004027 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866536004028 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536004029 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866536004030 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 866536004031 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 866536004032 Mg++ binding site [ion binding]; other site 866536004033 putative catalytic motif [active] 866536004034 putative substrate binding site [chemical binding]; other site 866536004035 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 866536004036 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536004037 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866536004038 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 866536004039 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 866536004040 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 866536004041 active site 866536004042 homodimer interface [polypeptide binding]; other site 866536004043 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 866536004044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866536004045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536004046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 866536004047 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 866536004048 cell division protein FtsA; Region: ftsA; TIGR01174 866536004049 Cell division protein FtsA; Region: FtsA; smart00842 866536004050 Cell division protein FtsA; Region: FtsA; pfam14450 866536004051 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 866536004052 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 866536004053 nucleotide binding site [chemical binding]; other site 866536004054 SulA interaction site; other site 866536004055 Predicted flavoprotein [General function prediction only]; Region: COG0431 866536004056 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 866536004057 purine nucleoside phosphorylase; Provisional; Region: PRK08202 866536004058 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 866536004059 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 866536004060 active site 866536004061 catalytic site [active] 866536004062 substrate binding site [chemical binding]; other site 866536004063 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 866536004064 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 866536004065 active site 866536004066 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 866536004067 generic binding surface II; other site 866536004068 generic binding surface I; other site 866536004069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 866536004070 catalytic residues [active] 866536004071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 866536004072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 866536004073 Protein of unknown function (DUF502); Region: DUF502; pfam04367 866536004074 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 866536004075 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 866536004076 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 866536004077 FMN-binding domain; Region: FMN_bind; cl01081 866536004078 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 866536004079 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 866536004080 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 866536004081 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 866536004082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 866536004083 LytB protein; Region: LYTB; cl00507 866536004084 cytidylate kinase; Provisional; Region: cmk; PRK00023 866536004085 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 866536004086 CMP-binding site; other site 866536004087 The sites determining sugar specificity; other site 866536004088 adenine deaminase; Region: ade; TIGR01178 866536004089 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 866536004090 active site 866536004091 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 866536004092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536004093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536004094 active site 866536004095 AAA domain; Region: AAA_14; pfam13173 866536004096 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536004097 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536004098 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536004099 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 866536004100 amphipathic channel; other site 866536004101 Asn-Pro-Ala signature motifs; other site 866536004102 glycerol kinase; Provisional; Region: glpK; PRK00047 866536004103 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 866536004104 N- and C-terminal domain interface [polypeptide binding]; other site 866536004105 active site 866536004106 MgATP binding site [chemical binding]; other site 866536004107 catalytic site [active] 866536004108 metal binding site [ion binding]; metal-binding site 866536004109 glycerol binding site [chemical binding]; other site 866536004110 homotetramer interface [polypeptide binding]; other site 866536004111 homodimer interface [polypeptide binding]; other site 866536004112 FBP binding site [chemical binding]; other site 866536004113 protein IIAGlc interface [polypeptide binding]; other site 866536004114 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 866536004115 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 866536004116 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 866536004117 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 866536004118 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 866536004119 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 866536004120 catalytic core [active] 866536004121 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866536004122 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866536004123 active site 866536004124 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 866536004125 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 866536004126 G1 box; other site 866536004127 putative GEF interaction site [polypeptide binding]; other site 866536004128 GTP/Mg2+ binding site [chemical binding]; other site 866536004129 Switch I region; other site 866536004130 G2 box; other site 866536004131 G3 box; other site 866536004132 Switch II region; other site 866536004133 G4 box; other site 866536004134 G5 box; other site 866536004135 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 866536004136 ribosome recycling factor; Reviewed; Region: frr; PRK00083 866536004137 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 866536004138 hinge region; other site 866536004139 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 866536004140 putative nucleotide binding site [chemical binding]; other site 866536004141 uridine monophosphate binding site [chemical binding]; other site 866536004142 homohexameric interface [polypeptide binding]; other site 866536004143 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 866536004144 carboxyltransferase (CT) interaction site; other site 866536004145 biotinylation site [posttranslational modification]; other site 866536004146 Peptidase family M1; Region: Peptidase_M1; pfam01433 866536004147 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 866536004148 Zn binding site [ion binding]; other site 866536004149 elongation factor Tu; Reviewed; Region: PRK12735 866536004150 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 866536004151 G1 box; other site 866536004152 GEF interaction site [polypeptide binding]; other site 866536004153 GTP/Mg2+ binding site [chemical binding]; other site 866536004154 Switch I region; other site 866536004155 G2 box; other site 866536004156 G3 box; other site 866536004157 Switch II region; other site 866536004158 G4 box; other site 866536004159 G5 box; other site 866536004160 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 866536004161 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 866536004162 Antibiotic Binding Site [chemical binding]; other site 866536004163 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 866536004164 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 866536004165 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 866536004166 putative homodimer interface [polypeptide binding]; other site 866536004167 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 866536004168 heterodimer interface [polypeptide binding]; other site 866536004169 homodimer interface [polypeptide binding]; other site 866536004170 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 866536004171 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 866536004172 23S rRNA interface [nucleotide binding]; other site 866536004173 L7/L12 interface [polypeptide binding]; other site 866536004174 putative thiostrepton binding site; other site 866536004175 L25 interface [polypeptide binding]; other site 866536004176 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 866536004177 mRNA/rRNA interface [nucleotide binding]; other site 866536004178 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 866536004179 23S rRNA interface [nucleotide binding]; other site 866536004180 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 866536004181 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 866536004182 core dimer interface [polypeptide binding]; other site 866536004183 peripheral dimer interface [polypeptide binding]; other site 866536004184 L10 interface [polypeptide binding]; other site 866536004185 L11 interface [polypeptide binding]; other site 866536004186 putative EF-Tu interaction site [polypeptide binding]; other site 866536004187 putative EF-G interaction site [polypeptide binding]; other site 866536004188 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 866536004189 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 866536004190 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 866536004191 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 866536004192 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 866536004193 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 866536004194 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 866536004195 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 866536004196 RPB3 interaction site [polypeptide binding]; other site 866536004197 RPB1 interaction site [polypeptide binding]; other site 866536004198 RPB11 interaction site [polypeptide binding]; other site 866536004199 RPB10 interaction site [polypeptide binding]; other site 866536004200 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 866536004201 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 866536004202 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 866536004203 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 866536004204 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 866536004205 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 866536004206 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 866536004207 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 866536004208 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 866536004209 DNA binding site [nucleotide binding] 866536004210 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 866536004211 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 866536004212 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 866536004213 S17 interaction site [polypeptide binding]; other site 866536004214 S8 interaction site; other site 866536004215 16S rRNA interaction site [nucleotide binding]; other site 866536004216 streptomycin interaction site [chemical binding]; other site 866536004217 23S rRNA interaction site [nucleotide binding]; other site 866536004218 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 866536004219 30S ribosomal protein S7; Validated; Region: PRK05302 866536004220 elongation factor G; Reviewed; Region: PRK12739 866536004221 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 866536004222 G1 box; other site 866536004223 putative GEF interaction site [polypeptide binding]; other site 866536004224 GTP/Mg2+ binding site [chemical binding]; other site 866536004225 Switch I region; other site 866536004226 G2 box; other site 866536004227 G3 box; other site 866536004228 Switch II region; other site 866536004229 G4 box; other site 866536004230 G5 box; other site 866536004231 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 866536004232 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 866536004233 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 866536004234 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 866536004235 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 866536004236 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 866536004237 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 866536004238 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 866536004239 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 866536004240 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 866536004241 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 866536004242 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 866536004243 putative translocon binding site; other site 866536004244 protein-rRNA interface [nucleotide binding]; other site 866536004245 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 866536004246 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 866536004247 G-X-X-G motif; other site 866536004248 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 866536004249 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 866536004250 23S rRNA interface [nucleotide binding]; other site 866536004251 5S rRNA interface [nucleotide binding]; other site 866536004252 putative antibiotic binding site [chemical binding]; other site 866536004253 L25 interface [polypeptide binding]; other site 866536004254 L27 interface [polypeptide binding]; other site 866536004255 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 866536004256 putative translocon interaction site; other site 866536004257 23S rRNA interface [nucleotide binding]; other site 866536004258 signal recognition particle (SRP54) interaction site; other site 866536004259 L23 interface [polypeptide binding]; other site 866536004260 trigger factor interaction site; other site 866536004261 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 866536004262 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 866536004263 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 866536004264 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 866536004265 RNA binding site [nucleotide binding]; other site 866536004266 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 866536004267 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 866536004268 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 866536004269 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 866536004270 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 866536004271 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 866536004272 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 866536004273 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 866536004274 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 866536004275 5S rRNA interface [nucleotide binding]; other site 866536004276 23S rRNA interface [nucleotide binding]; other site 866536004277 L5 interface [polypeptide binding]; other site 866536004278 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 866536004279 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 866536004280 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 866536004281 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 866536004282 23S rRNA binding site [nucleotide binding]; other site 866536004283 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 866536004284 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 866536004285 SecY translocase; Region: SecY; pfam00344 866536004286 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 866536004287 active site 866536004288 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 866536004289 rRNA binding site [nucleotide binding]; other site 866536004290 predicted 30S ribosome binding site; other site 866536004291 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 866536004292 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 866536004293 30S ribosomal protein S13; Region: bact_S13; TIGR03631 866536004294 30S ribosomal protein S11; Validated; Region: PRK05309 866536004295 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 866536004296 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 866536004297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866536004298 RNA binding surface [nucleotide binding]; other site 866536004299 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 866536004300 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 866536004301 alphaNTD - beta interaction site [polypeptide binding]; other site 866536004302 alphaNTD homodimer interface [polypeptide binding]; other site 866536004303 alphaNTD - beta' interaction site [polypeptide binding]; other site 866536004304 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 866536004305 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 866536004306 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 866536004307 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 866536004308 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 866536004309 catalytic site [active] 866536004310 subunit interface [polypeptide binding]; other site 866536004311 enolase; Provisional; Region: eno; PRK00077 866536004312 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 866536004313 dimer interface [polypeptide binding]; other site 866536004314 metal binding site [ion binding]; metal-binding site 866536004315 substrate binding pocket [chemical binding]; other site 866536004316 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 866536004317 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 866536004318 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 866536004319 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 866536004320 protein binding site [polypeptide binding]; other site 866536004321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 866536004322 protein binding site [polypeptide binding]; other site 866536004323 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 866536004324 Mechanosensitive ion channel; Region: MS_channel; pfam00924 866536004325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 866536004326 MarR family; Region: MarR_2; pfam12802 866536004327 Uncharacterized conserved protein [Function unknown]; Region: COG2353 866536004328 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 866536004329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536004330 Zn binding site [ion binding]; other site 866536004331 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 866536004332 Zn binding site [ion binding]; other site 866536004333 putative hydrolase; Provisional; Region: PRK11460 866536004334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536004335 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536004336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 866536004337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536004338 active site 866536004339 L-arabinose isomerase; Provisional; Region: PRK02929 866536004340 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 866536004341 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 866536004342 trimer interface [polypeptide binding]; other site 866536004343 putative substrate binding site [chemical binding]; other site 866536004344 putative metal binding site [ion binding]; other site 866536004345 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 866536004346 Na binding site [ion binding]; other site 866536004347 substrate binding site [chemical binding]; other site 866536004348 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 866536004349 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 866536004350 nudix motif; other site 866536004351 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 866536004352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 866536004353 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 866536004354 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 866536004355 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 866536004356 ribulokinase; Provisional; Region: PRK04123 866536004357 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 866536004358 N- and C-terminal domain interface [polypeptide binding]; other site 866536004359 active site 866536004360 MgATP binding site [chemical binding]; other site 866536004361 catalytic site [active] 866536004362 metal binding site [ion binding]; metal-binding site 866536004363 carbohydrate binding site [chemical binding]; other site 866536004364 homodimer interface [polypeptide binding]; other site 866536004365 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 866536004366 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 866536004367 intersubunit interface [polypeptide binding]; other site 866536004368 active site 866536004369 Zn2+ binding site [ion binding]; other site 866536004370 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 866536004371 active site 866536004372 catalytic residues [active] 866536004373 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 866536004374 substrate binding site [chemical binding]; other site 866536004375 active site 866536004376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536004377 Archaeal ATPase; Region: Arch_ATPase; pfam01637 866536004378 Walker A motif; other site 866536004379 ATP binding site [chemical binding]; other site 866536004380 Walker B motif; other site 866536004381 arginine finger; other site 866536004382 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536004383 Nuclease-related domain; Region: NERD; pfam08378 866536004384 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 866536004385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536004386 Walker A/P-loop; other site 866536004387 ATP binding site [chemical binding]; other site 866536004388 Q-loop/lid; other site 866536004389 ABC transporter signature motif; other site 866536004390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536004391 ABC transporter signature motif; other site 866536004392 Walker B; other site 866536004393 D-loop; other site 866536004394 H-loop/switch region; other site 866536004395 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 866536004396 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 866536004397 active site 866536004398 metal binding site [ion binding]; metal-binding site 866536004399 DNA binding site [nucleotide binding] 866536004400 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 866536004401 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 866536004402 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536004403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536004404 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536004405 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536004406 Protein export membrane protein; Region: SecD_SecF; cl14618 866536004407 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536004408 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 866536004409 putative active site [active] 866536004410 Peptidase family M48; Region: Peptidase_M48; pfam01435 866536004411 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 866536004412 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 866536004413 hypothetical protein; Validated; Region: PRK02101 866536004414 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 866536004415 Septum formation initiator; Region: DivIC; cl17659 866536004416 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 866536004417 serine O-acetyltransferase; Region: cysE; TIGR01172 866536004418 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 866536004419 trimer interface [polypeptide binding]; other site 866536004420 active site 866536004421 substrate binding site [chemical binding]; other site 866536004422 CoA binding site [chemical binding]; other site 866536004423 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 866536004424 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 866536004425 dimer interface [polypeptide binding]; other site 866536004426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536004427 catalytic residue [active] 866536004428 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 866536004429 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 866536004430 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536004431 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536004432 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 866536004433 exopolyphosphatase; Region: exo_poly_only; TIGR03706 866536004434 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 866536004435 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 866536004436 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 866536004437 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 866536004438 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 866536004439 four helix bundle protein; Region: TIGR02436 866536004440 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 866536004441 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 866536004442 oligomer interface [polypeptide binding]; other site 866536004443 active site 866536004444 metal binding site [ion binding]; metal-binding site 866536004445 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 866536004446 Catalytic domain of Protein Kinases; Region: PKc; cd00180 866536004447 active site 866536004448 ATP binding site [chemical binding]; other site 866536004449 substrate binding site [chemical binding]; other site 866536004450 activation loop (A-loop); other site 866536004451 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536004452 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536004453 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866536004454 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536004455 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536004456 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866536004457 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536004458 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 866536004459 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 866536004460 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 866536004461 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 866536004462 ribonuclease P; Reviewed; Region: rnpA; PRK01903 866536004463 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 866536004464 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536004465 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 866536004466 protein binding site [polypeptide binding]; other site 866536004467 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 866536004468 Catalytic dyad [active] 866536004469 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 866536004470 Glycoprotease family; Region: Peptidase_M22; pfam00814 866536004471 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 866536004472 AAA domain; Region: AAA_30; pfam13604 866536004473 AAA domain; Region: AAA_22; pfam13401 866536004474 Family description; Region: UvrD_C_2; pfam13538 866536004475 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 866536004476 classical (c) SDRs; Region: SDR_c; cd05233 866536004477 NAD(P) binding site [chemical binding]; other site 866536004478 active site 866536004479 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 866536004480 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 866536004481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 866536004482 Protein of unknown function (DUF419); Region: DUF419; pfam04237 866536004483 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 866536004484 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 866536004485 Walker A/P-loop; other site 866536004486 ATP binding site [chemical binding]; other site 866536004487 Q-loop/lid; other site 866536004488 ABC transporter signature motif; other site 866536004489 Walker B; other site 866536004490 D-loop; other site 866536004491 H-loop/switch region; other site 866536004492 TOBE domain; Region: TOBE_2; pfam08402 866536004493 helicase 45; Provisional; Region: PTZ00424 866536004494 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866536004495 ATP binding site [chemical binding]; other site 866536004496 Mg++ binding site [ion binding]; other site 866536004497 motif III; other site 866536004498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536004499 nucleotide binding region [chemical binding]; other site 866536004500 ATP-binding site [chemical binding]; other site 866536004501 dihydroorotase; Validated; Region: pyrC; PRK09357 866536004502 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 866536004503 active site 866536004504 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 866536004505 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 866536004506 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536004507 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 866536004508 Ligand binding site; other site 866536004509 Putative Catalytic site; other site 866536004510 DXD motif; other site 866536004511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536004512 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 866536004513 active site 866536004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536004515 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536004516 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536004517 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536004518 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 866536004519 FtsX-like permease family; Region: FtsX; pfam02687 866536004520 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 866536004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 866536004522 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 866536004523 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 866536004524 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 866536004525 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 866536004526 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 866536004527 NAD(P) binding site [chemical binding]; other site 866536004528 homotetramer interface [polypeptide binding]; other site 866536004529 homodimer interface [polypeptide binding]; other site 866536004530 active site 866536004531 GxxExxY protein; Region: GxxExxY; TIGR04256 866536004532 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 866536004533 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 866536004534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536004535 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 866536004536 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 866536004537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536004538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536004539 DNA binding residues [nucleotide binding] 866536004540 Anti-sigma-K factor rskA; Region: RskA; pfam10099 866536004541 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 866536004542 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 866536004543 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 866536004544 putative active site [active] 866536004545 catalytic site [active] 866536004546 putative metal binding site [ion binding]; other site 866536004547 oligomer interface [polypeptide binding]; other site 866536004548 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 866536004549 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 866536004550 tetramer interface [polypeptide binding]; other site 866536004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536004552 catalytic residue [active] 866536004553 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 866536004554 recombination factor protein RarA; Reviewed; Region: PRK13342 866536004555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536004556 Walker A motif; other site 866536004557 ATP binding site [chemical binding]; other site 866536004558 Walker B motif; other site 866536004559 arginine finger; other site 866536004560 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 866536004561 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 866536004562 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536004563 Walker A/P-loop; other site 866536004564 ATP binding site [chemical binding]; other site 866536004565 Q-loop/lid; other site 866536004566 ABC transporter signature motif; other site 866536004567 Walker B; other site 866536004568 D-loop; other site 866536004569 H-loop/switch region; other site 866536004570 Protein of unknown function, DUF481; Region: DUF481; cl01213 866536004571 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 866536004572 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 866536004573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 866536004574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 866536004575 catalytic residue [active] 866536004576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536004577 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536004578 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 866536004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536004580 S-adenosylmethionine binding site [chemical binding]; other site 866536004581 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 866536004582 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 866536004583 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 866536004584 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 866536004585 proline aminopeptidase P II; Provisional; Region: PRK10879 866536004586 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 866536004587 active site 866536004588 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536004589 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536004590 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 866536004591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536004592 non-specific DNA binding site [nucleotide binding]; other site 866536004593 salt bridge; other site 866536004594 sequence-specific DNA binding site [nucleotide binding]; other site 866536004595 elongation factor Ts; Provisional; Region: tsf; PRK09377 866536004596 UBA/TS-N domain; Region: UBA; pfam00627 866536004597 Elongation factor TS; Region: EF_TS; pfam00889 866536004598 Elongation factor TS; Region: EF_TS; pfam00889 866536004599 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 866536004600 rRNA interaction site [nucleotide binding]; other site 866536004601 S8 interaction site; other site 866536004602 putative laminin-1 binding site; other site 866536004603 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 866536004604 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 866536004605 23S rRNA interface [nucleotide binding]; other site 866536004606 L3 interface [polypeptide binding]; other site 866536004607 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866536004608 active site 866536004609 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 866536004610 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 866536004611 putative catalytic site [active] 866536004612 putative metal binding site [ion binding]; other site 866536004613 putative phosphate binding site [ion binding]; other site 866536004614 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 866536004615 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 866536004616 tandem repeat interface [polypeptide binding]; other site 866536004617 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 866536004618 oligomer interface [polypeptide binding]; other site 866536004619 active site residues [active] 866536004620 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 866536004621 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 866536004622 tandem repeat interface [polypeptide binding]; other site 866536004623 oligomer interface [polypeptide binding]; other site 866536004624 active site residues [active] 866536004625 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 866536004626 catalytic center binding site [active] 866536004627 ATP binding site [chemical binding]; other site 866536004628 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 866536004629 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 866536004630 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 866536004631 active site clefts [active] 866536004632 zinc binding site [ion binding]; other site 866536004633 dimer interface [polypeptide binding]; other site 866536004634 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 866536004635 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 866536004636 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 866536004637 putative Iron-sulfur protein interface [polypeptide binding]; other site 866536004638 proximal heme binding site [chemical binding]; other site 866536004639 distal heme binding site [chemical binding]; other site 866536004640 putative dimer interface [polypeptide binding]; other site 866536004641 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 866536004642 L-aspartate oxidase; Provisional; Region: PRK06175 866536004643 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 866536004644 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 866536004645 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 866536004646 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 866536004647 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 866536004648 Na binding site [ion binding]; other site 866536004649 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 866536004650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536004651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 866536004652 Coenzyme A binding pocket [chemical binding]; other site 866536004653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 866536004654 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 866536004655 dimer interface [polypeptide binding]; other site 866536004656 active site 866536004657 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536004658 substrate binding site [chemical binding]; other site 866536004659 catalytic residue [active] 866536004660 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536004661 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 866536004662 active site 866536004663 putative DNA-binding cleft [nucleotide binding]; other site 866536004664 dimer interface [polypeptide binding]; other site 866536004665 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536004666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536004667 active site 866536004668 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 866536004669 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 866536004670 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 866536004671 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 866536004672 NodB motif; other site 866536004673 active site 866536004674 catalytic site [active] 866536004675 metal binding site [ion binding]; metal-binding site 866536004676 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 866536004677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536004678 active site 866536004679 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 866536004680 active site 866536004681 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 866536004682 active site 866536004683 homodimer interface [polypeptide binding]; other site 866536004684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536004685 non-specific DNA binding site [nucleotide binding]; other site 866536004686 salt bridge; other site 866536004687 sequence-specific DNA binding site [nucleotide binding]; other site 866536004688 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 866536004689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536004690 Putative transposase; Region: Y2_Tnp; pfam04986 866536004691 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 866536004692 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 866536004693 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 866536004694 putative carbohydrate kinase; Provisional; Region: PRK10565 866536004695 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 866536004696 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 866536004697 putative substrate binding site [chemical binding]; other site 866536004698 putative ATP binding site [chemical binding]; other site 866536004699 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 866536004700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536004701 putative substrate translocation pore; other site 866536004702 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 866536004703 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 866536004704 putative dimer interface [polypeptide binding]; other site 866536004705 putative anticodon binding site; other site 866536004706 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 866536004707 homodimer interface [polypeptide binding]; other site 866536004708 motif 1; other site 866536004709 motif 2; other site 866536004710 active site 866536004711 motif 3; other site 866536004712 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 866536004713 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 866536004714 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 866536004715 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 866536004716 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 866536004717 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536004718 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 866536004719 dimer interface [polypeptide binding]; other site 866536004720 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 866536004721 active site 866536004722 heme binding site [chemical binding]; other site 866536004723 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 866536004724 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 866536004725 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 866536004726 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 866536004727 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 866536004728 active site 866536004729 catalytic triad [active] 866536004730 oxyanion hole [active] 866536004731 switch loop; other site 866536004732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866536004733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866536004734 Walker A/P-loop; other site 866536004735 ATP binding site [chemical binding]; other site 866536004736 Q-loop/lid; other site 866536004737 ABC transporter signature motif; other site 866536004738 Walker B; other site 866536004739 D-loop; other site 866536004740 H-loop/switch region; other site 866536004741 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 866536004742 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536004743 FtsX-like permease family; Region: FtsX; pfam02687 866536004744 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 866536004745 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 866536004746 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 866536004747 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 866536004748 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 866536004749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536004750 Walker A motif; other site 866536004751 ATP binding site [chemical binding]; other site 866536004752 Walker B motif; other site 866536004753 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 866536004754 Clp protease; Region: CLP_protease; pfam00574 866536004755 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 866536004756 oligomer interface [polypeptide binding]; other site 866536004757 active site residues [active] 866536004758 trigger factor; Region: tig; TIGR00115 866536004759 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 866536004760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866536004761 Zn2+ binding site [ion binding]; other site 866536004762 Mg2+ binding site [ion binding]; other site 866536004763 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 866536004764 synthetase active site [active] 866536004765 NTP binding site [chemical binding]; other site 866536004766 metal binding site [ion binding]; metal-binding site 866536004767 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 866536004768 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 866536004769 ferric uptake regulator; Provisional; Region: fur; PRK09462 866536004770 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 866536004771 metal binding site 2 [ion binding]; metal-binding site 866536004772 putative DNA binding helix; other site 866536004773 metal binding site 1 [ion binding]; metal-binding site 866536004774 dimer interface [polypeptide binding]; other site 866536004775 structural Zn2+ binding site [ion binding]; other site 866536004776 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 866536004777 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 866536004778 anti sigma factor interaction site; other site 866536004779 regulatory phosphorylation site [posttranslational modification]; other site 866536004780 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 866536004781 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 866536004782 GDP-binding site [chemical binding]; other site 866536004783 ACT binding site; other site 866536004784 IMP binding site; other site 866536004785 legume lectins; Region: lectin_L-type; cl14058 866536004786 homodimer interaction site [polypeptide binding]; other site 866536004787 homotetramer interaction site [polypeptide binding]; other site 866536004788 carbohydrate binding site [chemical binding]; other site 866536004789 metal binding site [ion binding]; metal-binding site 866536004790 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 866536004791 FOG: PKD repeat [General function prediction only]; Region: COG3291 866536004792 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 866536004793 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 866536004794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536004795 active site 866536004796 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 866536004797 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 866536004798 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 866536004799 hypothetical protein; Provisional; Region: PRK08609 866536004800 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 866536004801 metal binding triad [ion binding]; metal-binding site 866536004802 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 866536004803 active site 866536004804 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 866536004805 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536004806 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536004807 Fic/DOC family; Region: Fic; pfam02661 866536004808 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 866536004809 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 866536004810 dimer interface [polypeptide binding]; other site 866536004811 active site residues [active] 866536004812 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 866536004813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536004814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536004815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536004816 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 866536004817 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 866536004818 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 866536004819 active site 866536004820 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536004821 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 866536004822 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866536004823 homodimer interface [polypeptide binding]; other site 866536004824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536004825 substrate-cofactor binding pocket; other site 866536004826 catalytic residue [active] 866536004827 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 866536004828 putative active site [active] 866536004829 catalytic residue [active] 866536004830 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 866536004831 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 866536004832 5S rRNA interface [nucleotide binding]; other site 866536004833 CTC domain interface [polypeptide binding]; other site 866536004834 L16 interface [polypeptide binding]; other site 866536004835 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 866536004836 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 866536004837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536004838 active site 866536004839 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 866536004840 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 866536004841 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 866536004842 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 866536004843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536004844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536004845 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536004846 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 866536004847 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 866536004848 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 866536004849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536004850 Walker A/P-loop; other site 866536004851 ATP binding site [chemical binding]; other site 866536004852 Q-loop/lid; other site 866536004853 ABC transporter signature motif; other site 866536004854 Walker B; other site 866536004855 D-loop; other site 866536004856 H-loop/switch region; other site 866536004857 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 866536004858 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 866536004859 NosL; Region: NosL; cl01769 866536004860 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 866536004861 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 866536004862 Cytochrome c; Region: Cytochrom_C; pfam00034 866536004863 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 866536004864 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 866536004865 Hemerythrin-like domain; Region: Hr-like; cd12108 866536004866 Predicted transcriptional regulator [Transcription]; Region: COG1959 866536004867 Transcriptional regulator; Region: Rrf2; pfam02082 866536004868 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 866536004869 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 866536004870 dimer interface [polypeptide binding]; other site 866536004871 FMN binding site [chemical binding]; other site 866536004872 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 866536004873 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 866536004874 trimer interface [polypeptide binding]; other site 866536004875 dimer interface [polypeptide binding]; other site 866536004876 putative active site [active] 866536004877 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 866536004878 MPT binding site; other site 866536004879 trimer interface [polypeptide binding]; other site 866536004880 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 866536004881 MoaE homodimer interface [polypeptide binding]; other site 866536004882 MoaD interaction [polypeptide binding]; other site 866536004883 active site residues [active] 866536004884 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 866536004885 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 866536004886 ATP binding site [chemical binding]; other site 866536004887 substrate interface [chemical binding]; other site 866536004888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536004889 active site residue [active] 866536004890 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 866536004891 MoaE interaction surface [polypeptide binding]; other site 866536004892 MoeB interaction surface [polypeptide binding]; other site 866536004893 thiocarboxylated glycine; other site 866536004894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536004895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536004896 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 866536004897 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 866536004898 GTP binding site; other site 866536004899 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 866536004900 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 866536004901 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 866536004902 dimer interface [polypeptide binding]; other site 866536004903 putative functional site; other site 866536004904 putative MPT binding site; other site 866536004905 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 866536004906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536004907 FeS/SAM binding site; other site 866536004908 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 866536004909 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 866536004910 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 866536004911 iron-sulfur cluster [ion binding]; other site 866536004912 [2Fe-2S] cluster binding site [ion binding]; other site 866536004913 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 866536004914 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 866536004915 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 866536004916 [4Fe-4S] binding site [ion binding]; other site 866536004917 molybdopterin cofactor binding site; other site 866536004918 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 866536004919 molybdopterin cofactor binding site; other site 866536004920 CitB domain protein; Region: CitB; TIGR02484 866536004921 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 866536004922 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 866536004923 active site 866536004924 HPP family; Region: HPP; pfam04982 866536004925 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 866536004926 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 866536004927 Cu(I) binding site [ion binding]; other site 866536004928 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 866536004929 Uncharacterized conserved protein [Function unknown]; Region: COG1262 866536004930 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 866536004931 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 866536004932 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 866536004933 Cytochrome c; Region: Cytochrom_C; pfam00034 866536004934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536004935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536004936 ligand binding site [chemical binding]; other site 866536004937 flexible hinge region; other site 866536004938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 866536004939 non-specific DNA interactions [nucleotide binding]; other site 866536004940 DNA binding site [nucleotide binding] 866536004941 sequence specific DNA binding site [nucleotide binding]; other site 866536004942 putative cAMP binding site [chemical binding]; other site 866536004943 Cytochrome c; Region: Cytochrom_C; pfam00034 866536004944 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 866536004945 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 866536004946 Binuclear center (active site) [active] 866536004947 K-pathway; other site 866536004948 Putative proton exit pathway; other site 866536004949 MoxR-like ATPases [General function prediction only]; Region: COG0714 866536004950 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 866536004951 Walker A motif; other site 866536004952 ATP binding site [chemical binding]; other site 866536004953 Walker B motif; other site 866536004954 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 866536004955 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 866536004956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 866536004957 metal ion-dependent adhesion site (MIDAS); other site 866536004958 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 866536004959 Subunit I/III interface [polypeptide binding]; other site 866536004960 GxxExxY protein; Region: GxxExxY; TIGR04256 866536004961 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 866536004962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536004963 FeS/SAM binding site; other site 866536004964 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 866536004965 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 866536004966 ATP cone domain; Region: ATP-cone; pfam03477 866536004967 Class III ribonucleotide reductase; Region: RNR_III; cd01675 866536004968 effector binding site; other site 866536004969 active site 866536004970 Zn binding site [ion binding]; other site 866536004971 Predicted transcriptional regulator [Transcription]; Region: COG1959 866536004972 Transcriptional regulator; Region: Rrf2; pfam02082 866536004973 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 866536004974 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 866536004975 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 866536004976 Fasciclin domain; Region: Fasciclin; pfam02469 866536004977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536004978 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 866536004979 dimer interface [polypeptide binding]; other site 866536004980 substrate binding site [chemical binding]; other site 866536004981 metal binding site [ion binding]; metal-binding site 866536004982 thiamine monophosphate kinase; Provisional; Region: PRK05731 866536004983 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 866536004984 ATP binding site [chemical binding]; other site 866536004985 dimerization interface [polypeptide binding]; other site 866536004986 ERCC4-type nuclease [DNA replication, recombination, and repair]; Region: MUS81; COG1948 866536004987 ERCC4 domain; Region: ERCC4; smart00891 866536004988 TRAM domain; Region: TRAM; pfam01938 866536004989 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 866536004990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536004991 S-adenosylmethionine binding site [chemical binding]; other site 866536004992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536004993 short chain dehydrogenase; Provisional; Region: PRK06181 866536004994 NAD(P) binding site [chemical binding]; other site 866536004995 active site 866536004996 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 866536004997 AAA domain; Region: AAA_11; pfam13086 866536004998 Part of AAA domain; Region: AAA_19; pfam13245 866536004999 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 866536005000 AAA domain; Region: AAA_12; pfam13087 866536005001 GldH lipoprotein; Region: GldH_lipo; cl11905 866536005002 PSP1 C-terminal conserved region; Region: PSP1; cl00770 866536005003 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 866536005004 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 866536005005 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 866536005006 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 866536005007 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 866536005008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536005009 ATP binding site [chemical binding]; other site 866536005010 putative Mg++ binding site [ion binding]; other site 866536005011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536005012 nucleotide binding region [chemical binding]; other site 866536005013 ATP-binding site [chemical binding]; other site 866536005014 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 866536005015 HRDC domain; Region: HRDC; pfam00570 866536005016 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 866536005017 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 866536005018 putative active site [active] 866536005019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 866536005020 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 866536005021 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 866536005022 Substrate binding site; other site 866536005023 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 866536005024 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 866536005025 active site 866536005026 metal binding site [ion binding]; metal-binding site 866536005027 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 866536005028 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 866536005029 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 866536005030 active site 866536005031 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 866536005032 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536005033 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536005034 ligand binding site [chemical binding]; other site 866536005035 flexible hinge region; other site 866536005036 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 866536005037 putative switch regulator; other site 866536005038 non-specific DNA interactions [nucleotide binding]; other site 866536005039 DNA binding site [nucleotide binding] 866536005040 sequence specific DNA binding site [nucleotide binding]; other site 866536005041 putative cAMP binding site [chemical binding]; other site 866536005042 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536005043 active site residue [active] 866536005044 Protein of unknown function, DUF547; Region: DUF547; pfam04784 866536005045 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 866536005046 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536005047 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 866536005048 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 866536005049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536005050 active site 866536005051 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 866536005052 Ligand binding site; other site 866536005053 Putative Catalytic site; other site 866536005054 DXD motif; other site 866536005055 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 866536005056 Haem-binding domain; Region: Haem_bd; pfam14376 866536005057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536005058 Transposase; Region: HTH_Tnp_1; cl17663 866536005059 Integrase core domain; Region: rve; pfam00665 866536005060 Integrase core domain; Region: rve_3; pfam13683 866536005061 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866536005062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 866536005063 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 866536005064 putative transposase OrfB; Reviewed; Region: PHA02517 866536005065 HTH-like domain; Region: HTH_21; pfam13276 866536005066 Integrase core domain; Region: rve; pfam00665 866536005067 Integrase core domain; Region: rve_3; pfam13683 866536005068 PIN domain; Region: PIN_3; cl17397 866536005069 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 866536005070 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 866536005071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536005072 MULE transposase domain; Region: MULE; pfam10551 866536005073 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 866536005074 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 866536005075 DNA-binding interface [nucleotide binding]; DNA binding site 866536005076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 866536005077 Integrase core domain; Region: rve; pfam00665 866536005078 Integrase core domain; Region: rve_3; pfam13683 866536005079 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 866536005080 Protein of unknown function, DUF399; Region: DUF399; pfam04187 866536005081 Dihydroneopterin aldolase; Region: FolB; pfam02152 866536005082 active site 866536005083 DivIVA protein; Region: DivIVA; pfam05103 866536005084 DivIVA domain; Region: DivI1A_domain; TIGR03544 866536005085 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 866536005086 FOG: WD40 repeat [General function prediction only]; Region: COG2319 866536005087 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 866536005088 structural tetrad; other site 866536005089 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 866536005090 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 866536005091 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 866536005092 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536005093 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 866536005094 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 866536005095 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 866536005096 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 866536005097 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 866536005098 active site 866536005099 metal binding site [ion binding]; metal-binding site 866536005100 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 866536005101 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 866536005102 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 866536005103 substrate binding site; other site 866536005104 tetramer interface; other site 866536005105 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 866536005106 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 866536005107 Mg++ binding site [ion binding]; other site 866536005108 putative catalytic motif [active] 866536005109 substrate binding site [chemical binding]; other site 866536005110 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 866536005111 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 866536005112 inhibitor-cofactor binding pocket; inhibition site 866536005113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536005114 catalytic residue [active] 866536005115 Bacterial sugar transferase; Region: Bac_transf; pfam02397 866536005116 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 866536005117 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 866536005118 putative trimer interface [polypeptide binding]; other site 866536005119 putative CoA binding site [chemical binding]; other site 866536005120 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 866536005121 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 866536005122 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 866536005123 NAD(P) binding site [chemical binding]; other site 866536005124 homodimer interface [polypeptide binding]; other site 866536005125 substrate binding site [chemical binding]; other site 866536005126 active site 866536005127 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 866536005128 methionine sulfoxide reductase A; Provisional; Region: PRK13014 866536005129 methionine sulfoxide reductase B; Provisional; Region: PRK00222 866536005130 SelR domain; Region: SelR; pfam01641 866536005131 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536005132 active site 866536005133 Zn binding site [ion binding]; other site 866536005134 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 866536005135 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536005136 ligand binding site [chemical binding]; other site 866536005137 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536005138 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 866536005139 DNA binding residues [nucleotide binding] 866536005140 dimerization interface [polypeptide binding]; other site 866536005141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 866536005142 active site 866536005143 Ion channel; Region: Ion_trans_2; pfam07885 866536005144 TrkA-N domain; Region: TrkA_N; pfam02254 866536005145 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 866536005146 TrkA-C domain; Region: TrkA_C; pfam02080 866536005147 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 866536005148 TrkA-N domain; Region: TrkA_N; pfam02254 866536005149 TrkA-C domain; Region: TrkA_C; pfam02080 866536005150 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 866536005151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536005152 putative ADP-binding pocket [chemical binding]; other site 866536005153 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 866536005154 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 866536005155 putative NAD(P) binding site [chemical binding]; other site 866536005156 active site 866536005157 putative substrate binding site [chemical binding]; other site 866536005158 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 866536005159 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 866536005160 NAD binding site [chemical binding]; other site 866536005161 substrate binding site [chemical binding]; other site 866536005162 homodimer interface [polypeptide binding]; other site 866536005163 active site 866536005164 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 866536005165 VPS10 domain; Region: VPS10; smart00602 866536005166 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 866536005167 Zn binding site [ion binding]; other site 866536005168 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 866536005169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 866536005170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536005171 catalytic residue [active] 866536005172 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 866536005173 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866536005174 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 866536005175 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 866536005176 Uncharacterized conserved protein [Function unknown]; Region: COG4198 866536005177 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 866536005178 Maf-like protein; Region: Maf; pfam02545 866536005179 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 866536005180 active site 866536005181 dimer interface [polypeptide binding]; other site 866536005182 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536005183 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536005184 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536005185 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536005186 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 866536005187 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 866536005188 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 866536005189 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 866536005190 putative L-serine binding site [chemical binding]; other site 866536005191 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 866536005192 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 866536005193 homodimer interface [polypeptide binding]; other site 866536005194 substrate-cofactor binding pocket; other site 866536005195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536005196 catalytic residue [active] 866536005197 thymidylate synthase; Reviewed; Region: thyA; PRK01827 866536005198 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 866536005199 dimerization interface [polypeptide binding]; other site 866536005200 active site 866536005201 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 866536005202 Protein export membrane protein; Region: SecD_SecF; cl14618 866536005203 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536005204 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 866536005205 cofactor binding site; other site 866536005206 DNA binding site [nucleotide binding] 866536005207 substrate interaction site [chemical binding]; other site 866536005208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536005209 non-specific DNA binding site [nucleotide binding]; other site 866536005210 salt bridge; other site 866536005211 sequence-specific DNA binding site [nucleotide binding]; other site 866536005212 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 866536005213 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 866536005214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536005215 FtsX-like permease family; Region: FtsX; pfam02687 866536005216 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 866536005217 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 866536005218 Ligand binding site; other site 866536005219 Putative Catalytic site; other site 866536005220 DXD motif; other site 866536005221 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 866536005222 SIR2-like domain; Region: SIR2_2; pfam13289 866536005223 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 866536005224 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866536005225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536005226 ATP binding site [chemical binding]; other site 866536005227 putative Mg++ binding site [ion binding]; other site 866536005228 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 866536005229 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 866536005230 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 866536005231 Domain of unknown function DUF87; Region: DUF87; pfam01935 866536005232 HerA helicase [Replication, recombination, and repair]; Region: COG0433 866536005233 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 866536005234 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536005235 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866536005236 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866536005237 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866536005238 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536005239 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536005240 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536005241 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536005242 Integrase core domain; Region: rve; pfam00665 866536005243 Integrase core domain; Region: rve_3; pfam13683 866536005244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536005245 Transposase; Region: HTH_Tnp_1; cl17663 866536005246 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 866536005247 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536005248 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536005249 active site 866536005250 DNA binding site [nucleotide binding] 866536005251 Int/Topo IB signature motif; other site 866536005252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 866536005253 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 866536005254 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 866536005255 active site 866536005256 Domain of unknown function (DUF303); Region: DUF303; pfam03629 866536005257 Domain of unknown function (DUF303); Region: DUF303; pfam03629 866536005258 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536005259 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536005260 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536005261 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536005262 starch binding outer membrane protein SusD; Region: SusD; cl17845 866536005263 SusD family; Region: SusD; pfam07980 866536005264 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536005265 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536005266 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536005267 starch binding outer membrane protein SusD; Region: SusD; cl17845 866536005268 SusD family; Region: SusD; pfam07980 866536005269 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 866536005270 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 866536005271 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 866536005272 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 866536005273 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 866536005274 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 866536005275 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 866536005276 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 866536005277 active site 866536005278 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 866536005279 substrate binding site [chemical binding]; other site 866536005280 active site 866536005281 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 866536005282 metal binding site [ion binding]; metal-binding site 866536005283 ligand binding site [chemical binding]; other site 866536005284 Domain of unknown function (DUF303); Region: DUF303; pfam03629 866536005285 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 866536005286 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 866536005287 inhibitor binding site; inhibition site 866536005288 active site 866536005289 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536005290 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 866536005291 active site 866536005292 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 866536005293 metal binding site [ion binding]; metal-binding site 866536005294 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 866536005295 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 866536005296 substrate binding site [chemical binding]; other site 866536005297 active site 866536005298 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 866536005299 metal binding site [ion binding]; metal-binding site 866536005300 ligand binding site [chemical binding]; other site 866536005301 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 866536005302 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536005303 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536005304 Putative esterase; Region: Esterase; pfam00756 866536005305 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 866536005306 HipA N-terminal domain; Region: Couple_hipA; pfam13657 866536005307 HipA-like N-terminal domain; Region: HipA_N; pfam07805 866536005308 HipA-like C-terminal domain; Region: HipA_C; pfam07804 866536005309 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 866536005310 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 866536005311 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 866536005312 Protein of unknown function (DUF904); Region: DUF904; pfam06005 866536005313 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536005314 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 866536005315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 866536005316 classical (c) SDRs; Region: SDR_c; cd05233 866536005317 NAD(P) binding site [chemical binding]; other site 866536005318 active site 866536005319 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 866536005320 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 866536005321 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 866536005322 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536005323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536005324 DNA binding site [nucleotide binding] 866536005325 domain linker motif; other site 866536005326 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536005327 dimerization interface [polypeptide binding]; other site 866536005328 ligand binding site [chemical binding]; other site 866536005329 mannonate dehydratase; Provisional; Region: PRK03906 866536005330 mannonate dehydratase; Region: uxuA; TIGR00695 866536005331 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 866536005332 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 866536005333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 866536005334 nucleotide binding site [chemical binding]; other site 866536005335 xylose isomerase; Provisional; Region: PRK05474 866536005336 xylose isomerase; Region: xylose_isom_A; TIGR02630 866536005337 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 866536005338 substrate binding site [chemical binding]; other site 866536005339 active site 866536005340 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 866536005341 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 866536005342 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 866536005343 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 866536005344 D-mannonate oxidoreductase; Provisional; Region: PRK08277 866536005345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536005346 NAD(P) binding site [chemical binding]; other site 866536005347 active site 866536005348 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536005349 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536005350 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536005351 MULE transposase domain; Region: MULE; pfam10551 866536005352 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536005353 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 866536005354 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 866536005355 Clp amino terminal domain; Region: Clp_N; pfam02861 866536005356 Clp amino terminal domain; Region: Clp_N; pfam02861 866536005357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536005358 Walker A motif; other site 866536005359 ATP binding site [chemical binding]; other site 866536005360 Walker B motif; other site 866536005361 arginine finger; other site 866536005362 UvrB/uvrC motif; Region: UVR; pfam02151 866536005363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536005364 Walker A motif; other site 866536005365 ATP binding site [chemical binding]; other site 866536005366 Walker B motif; other site 866536005367 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 866536005368 WbqC-like protein family; Region: WbqC; pfam08889 866536005369 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 866536005370 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 866536005371 active site 866536005372 8-oxo-dGMP binding site [chemical binding]; other site 866536005373 nudix motif; other site 866536005374 metal binding site [ion binding]; metal-binding site 866536005375 YceG-like family; Region: YceG; pfam02618 866536005376 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 866536005377 dimerization interface [polypeptide binding]; other site 866536005378 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 866536005379 active site 866536005380 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 866536005381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005382 TPR motif; other site 866536005383 TPR repeat; Region: TPR_11; pfam13414 866536005384 binding surface 866536005385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005386 binding surface 866536005387 TPR motif; other site 866536005388 TPR repeat; Region: TPR_11; pfam13414 866536005389 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 866536005390 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 866536005391 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536005392 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536005393 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 866536005394 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 866536005395 putative active site [active] 866536005396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536005397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536005398 Walker A/P-loop; other site 866536005399 ATP binding site [chemical binding]; other site 866536005400 Q-loop/lid; other site 866536005401 ABC transporter signature motif; other site 866536005402 Walker B; other site 866536005403 D-loop; other site 866536005404 H-loop/switch region; other site 866536005405 HTH domain; Region: HTH_11; cl17392 866536005406 CAAX protease self-immunity; Region: Abi; pfam02517 866536005407 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 866536005408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536005409 active site 866536005410 motif I; other site 866536005411 motif II; other site 866536005412 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 866536005413 putative active site pocket [active] 866536005414 4-fold oligomerization interface [polypeptide binding]; other site 866536005415 metal binding residues [ion binding]; metal-binding site 866536005416 3-fold/trimer interface [polypeptide binding]; other site 866536005417 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 866536005418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866536005419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536005420 homodimer interface [polypeptide binding]; other site 866536005421 catalytic residue [active] 866536005422 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 866536005423 histidinol dehydrogenase; Region: hisD; TIGR00069 866536005424 NAD binding site [chemical binding]; other site 866536005425 dimerization interface [polypeptide binding]; other site 866536005426 product binding site; other site 866536005427 substrate binding site [chemical binding]; other site 866536005428 zinc binding site [ion binding]; other site 866536005429 catalytic residues [active] 866536005430 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 866536005431 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 866536005432 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 866536005433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536005434 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 866536005435 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 866536005436 active site 866536005437 catalytic triad [active] 866536005438 oxyanion hole [active] 866536005439 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 866536005440 putative rRNA binding site [nucleotide binding]; other site 866536005441 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536005442 Ligand Binding Site [chemical binding]; other site 866536005443 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536005444 Ligand Binding Site [chemical binding]; other site 866536005445 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 866536005446 UbiA prenyltransferase family; Region: UbiA; pfam01040 866536005447 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 866536005448 catalytic residues [active] 866536005449 dimer interface [polypeptide binding]; other site 866536005450 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 866536005451 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 866536005452 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 866536005453 active site 866536005454 HIGH motif; other site 866536005455 KMSK motif region; other site 866536005456 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 866536005457 tRNA binding surface [nucleotide binding]; other site 866536005458 anticodon binding site; other site 866536005459 Arginase family; Region: Arginase; cd09989 866536005460 active site 866536005461 Mn binding site [ion binding]; other site 866536005462 oligomer interface [polypeptide binding]; other site 866536005463 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 866536005464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 866536005465 dimer interface [polypeptide binding]; other site 866536005466 active site 866536005467 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536005468 catalytic residues [active] 866536005469 substrate binding site [chemical binding]; other site 866536005470 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 866536005471 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 866536005472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 866536005473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536005474 catalytic residue [active] 866536005475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536005476 non-specific DNA binding site [nucleotide binding]; other site 866536005477 salt bridge; other site 866536005478 sequence-specific DNA binding site [nucleotide binding]; other site 866536005479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536005481 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 866536005482 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 866536005483 dimer interface [polypeptide binding]; other site 866536005484 tetramer interface [polypeptide binding]; other site 866536005485 PYR/PP interface [polypeptide binding]; other site 866536005486 TPP binding site [chemical binding]; other site 866536005487 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 866536005488 TPP-binding site; other site 866536005489 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 866536005490 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 866536005491 CoenzymeA binding site [chemical binding]; other site 866536005492 subunit interaction site [polypeptide binding]; other site 866536005493 PHB binding site; other site 866536005494 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 866536005495 catalytic core [active] 866536005496 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 866536005497 Putative zinc ribbon domain; Region: DUF164; pfam02591 866536005498 Uncharacterized conserved protein [Function unknown]; Region: COG0327 866536005499 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 866536005500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 866536005501 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 866536005502 Uncharacterized conserved protein [Function unknown]; Region: COG0327 866536005503 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 866536005504 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 866536005505 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 866536005506 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 866536005507 active site 866536005508 dinuclear metal binding site [ion binding]; other site 866536005509 dimerization interface [polypeptide binding]; other site 866536005510 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 866536005511 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 866536005512 FtsX-like permease family; Region: FtsX; pfam02687 866536005513 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866536005514 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 866536005515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536005516 FeS/SAM binding site; other site 866536005517 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 866536005518 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 866536005519 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 866536005520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536005521 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536005522 DNA binding site [nucleotide binding] 866536005523 domain linker motif; other site 866536005524 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536005525 ligand binding site [chemical binding]; other site 866536005526 dimerization interface [polypeptide binding]; other site 866536005527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536005528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536005529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536005530 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 866536005531 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 866536005532 dimer interface [polypeptide binding]; other site 866536005533 active site 866536005534 CoA binding pocket [chemical binding]; other site 866536005535 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 866536005536 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 866536005537 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 866536005538 E3 interaction surface; other site 866536005539 lipoyl attachment site [posttranslational modification]; other site 866536005540 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 866536005541 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 866536005542 E3 interaction surface; other site 866536005543 lipoyl attachment site [posttranslational modification]; other site 866536005544 e3 binding domain; Region: E3_binding; pfam02817 866536005545 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 866536005546 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 866536005547 active site 866536005548 HslU subunit interaction site [polypeptide binding]; other site 866536005549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536005550 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 866536005551 ABC1 family; Region: ABC1; cl17513 866536005552 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 866536005553 active site 866536005554 ATP binding site [chemical binding]; other site 866536005555 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536005556 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 866536005557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536005558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536005559 ABC transporter; Region: ABC_tran_2; pfam12848 866536005560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536005561 Amidinotransferase; Region: Amidinotransf; cl12043 866536005562 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 866536005563 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 866536005564 dimer interface [polypeptide binding]; other site 866536005565 putative anticodon binding site; other site 866536005566 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 866536005567 motif 1; other site 866536005568 active site 866536005569 motif 2; other site 866536005570 motif 3; other site 866536005571 proline dehydrogenase; Region: PLN02681 866536005572 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 866536005573 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 866536005574 Chorismate mutase type II; Region: CM_2; smart00830 866536005575 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 866536005576 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 866536005577 Chorismate mutase type II; Region: CM_2; smart00830 866536005578 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 866536005579 active site 866536005580 dimer interface [polypeptide binding]; other site 866536005581 metal binding site [ion binding]; metal-binding site 866536005582 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 866536005583 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 866536005584 hinge; other site 866536005585 active site 866536005586 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 866536005587 Prephenate dehydratase; Region: PDT; pfam00800 866536005588 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 866536005589 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 866536005590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866536005591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536005592 homodimer interface [polypeptide binding]; other site 866536005593 catalytic residue [active] 866536005594 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 866536005595 prephenate dehydrogenase; Validated; Region: PRK08507 866536005596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536005597 sequence-specific DNA binding site [nucleotide binding]; other site 866536005598 salt bridge; other site 866536005599 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 866536005600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 866536005601 Beta-lactamase; Region: Beta-lactamase; pfam00144 866536005602 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 866536005603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536005604 active site 866536005605 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 866536005606 active site 866536005607 Ap6A binding site [chemical binding]; other site 866536005608 nudix motif; other site 866536005609 metal binding site [ion binding]; metal-binding site 866536005610 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 866536005611 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 866536005612 active site 866536005613 (T/H)XGH motif; other site 866536005614 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 866536005615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 866536005616 nudix motif; other site 866536005617 AAA domain; Region: AAA_30; pfam13604 866536005618 Family description; Region: UvrD_C_2; pfam13538 866536005619 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 866536005620 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 866536005621 active site 866536005622 NTP binding site [chemical binding]; other site 866536005623 metal binding triad [ion binding]; metal-binding site 866536005624 antibiotic binding site [chemical binding]; other site 866536005625 Protein of unknown function DUF86; Region: DUF86; cl01031 866536005626 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 866536005627 active site 866536005628 catalytic triad [active] 866536005629 oxyanion hole [active] 866536005630 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 866536005631 dimer interface [polypeptide binding]; other site 866536005632 catalytic triad [active] 866536005633 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 866536005634 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 866536005635 Protein of unknown function (DUF423); Region: DUF423; pfam04241 866536005636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 866536005637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 866536005638 catalytic residue [active] 866536005639 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 866536005640 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 866536005641 hexamer interface [polypeptide binding]; other site 866536005642 ligand binding site [chemical binding]; other site 866536005643 putative active site [active] 866536005644 NAD(P) binding site [chemical binding]; other site 866536005645 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 866536005646 tetramer interface [polypeptide binding]; other site 866536005647 TPP-binding site [chemical binding]; other site 866536005648 heterodimer interface [polypeptide binding]; other site 866536005649 phosphorylation loop region [posttranslational modification] 866536005650 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 866536005651 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 866536005652 PYR/PP interface [polypeptide binding]; other site 866536005653 dimer interface [polypeptide binding]; other site 866536005654 TPP binding site [chemical binding]; other site 866536005655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866536005656 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 866536005657 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 866536005658 dimerization interface [polypeptide binding]; other site 866536005659 ATP binding site [chemical binding]; other site 866536005660 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 866536005661 dimerization interface [polypeptide binding]; other site 866536005662 ATP binding site [chemical binding]; other site 866536005663 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 866536005664 putative active site [active] 866536005665 catalytic triad [active] 866536005666 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 866536005667 catalytic triad [active] 866536005668 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 866536005669 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 866536005670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536005671 ATP binding site [chemical binding]; other site 866536005672 putative Mg++ binding site [ion binding]; other site 866536005673 Uncharacterized conserved protein [Function unknown]; Region: COG5483 866536005674 Protein of unknown function, DUF488; Region: DUF488; pfam04343 866536005675 Protein of unknown function (DUF433); Region: DUF433; cl01030 866536005676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 866536005677 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536005678 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 866536005679 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536005680 Protein of unknown function DUF262; Region: DUF262; pfam03235 866536005681 Uncharacterized conserved protein [Function unknown]; Region: COG1479 866536005682 Protein of unknown function DUF262; Region: DUF262; pfam03235 866536005683 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 866536005684 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 866536005685 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866536005686 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866536005687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536005688 primosomal protein N' Region: priA; TIGR00595 866536005689 ATP binding site [chemical binding]; other site 866536005690 putative Mg++ binding site [ion binding]; other site 866536005691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536005692 ATP-binding site [chemical binding]; other site 866536005693 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536005694 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536005695 catalytic residues [active] 866536005696 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 866536005697 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 866536005698 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 866536005699 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 866536005700 RNA binding site [nucleotide binding]; other site 866536005701 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 866536005702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536005703 non-specific DNA binding site [nucleotide binding]; other site 866536005704 salt bridge; other site 866536005705 sequence-specific DNA binding site [nucleotide binding]; other site 866536005706 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 866536005707 Catalytic site [active] 866536005708 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536005709 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536005710 ligand binding site [chemical binding]; other site 866536005711 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 866536005712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866536005713 RNA binding surface [nucleotide binding]; other site 866536005714 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 866536005715 probable active site [active] 866536005716 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 866536005717 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 866536005718 AMP binding site [chemical binding]; other site 866536005719 active site 866536005720 acyl-activating enzyme (AAE) consensus motif; other site 866536005721 CoA binding site [chemical binding]; other site 866536005722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 866536005723 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 866536005724 substrate binding site [chemical binding]; other site 866536005725 oxyanion hole (OAH) forming residues; other site 866536005726 trimer interface [polypeptide binding]; other site 866536005727 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 866536005728 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 866536005729 PAS domain; Region: PAS_9; pfam13426 866536005730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536005731 Ligand Binding Site [chemical binding]; other site 866536005732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536005733 S-adenosylmethionine binding site [chemical binding]; other site 866536005734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536005735 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536005736 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 866536005737 active site residue [active] 866536005738 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 866536005739 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 866536005740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536005741 active site residue [active] 866536005742 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 866536005743 DNA photolyase; Region: DNA_photolyase; pfam00875 866536005744 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 866536005745 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 866536005746 putative active site [active] 866536005747 Penicillin amidase; Region: Penicil_amidase; pfam01804 866536005748 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536005749 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536005750 active site 866536005751 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536005752 Putative esterase; Region: Esterase; pfam00756 866536005753 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 866536005754 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 866536005755 YCII-related domain; Region: YCII; cl00999 866536005756 Domain of unknown function (DUF389); Region: DUF389; pfam04087 866536005757 Response regulator receiver domain; Region: Response_reg; pfam00072 866536005758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536005759 active site 866536005760 phosphorylation site [posttranslational modification] 866536005761 intermolecular recognition site; other site 866536005762 dimerization interface [polypeptide binding]; other site 866536005763 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 866536005764 Permease; Region: Permease; pfam02405 866536005765 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 866536005766 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 866536005767 Walker A/P-loop; other site 866536005768 ATP binding site [chemical binding]; other site 866536005769 Q-loop/lid; other site 866536005770 ABC transporter signature motif; other site 866536005771 Walker B; other site 866536005772 D-loop; other site 866536005773 H-loop/switch region; other site 866536005774 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 866536005775 mce related protein; Region: MCE; pfam02470 866536005776 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 866536005777 putative catalytic site [active] 866536005778 putative metal binding site [ion binding]; other site 866536005779 putative phosphate binding site [ion binding]; other site 866536005780 aconitate hydratase; Validated; Region: PRK09277 866536005781 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 866536005782 substrate binding site [chemical binding]; other site 866536005783 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 866536005784 ligand binding site [chemical binding]; other site 866536005785 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 866536005786 substrate binding site [chemical binding]; other site 866536005787 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 866536005788 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536005789 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 866536005790 active site 866536005791 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 866536005792 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 866536005793 active site 866536005794 dimer interface [polypeptide binding]; other site 866536005795 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 866536005796 dimer interface [polypeptide binding]; other site 866536005797 active site 866536005798 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536005799 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 866536005800 structural tetrad; other site 866536005801 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 866536005802 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536005803 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 866536005804 protein binding site [polypeptide binding]; other site 866536005805 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 866536005806 Domain interface; other site 866536005807 Peptide binding site; other site 866536005808 Active site tetrad [active] 866536005809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 866536005810 dimerization interface [polypeptide binding]; other site 866536005811 putative DNA binding site [nucleotide binding]; other site 866536005812 putative Zn2+ binding site [ion binding]; other site 866536005813 GxxExxY protein; Region: GxxExxY; TIGR04256 866536005814 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 866536005815 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 866536005816 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 866536005817 SLBB domain; Region: SLBB; pfam10531 866536005818 SLBB domain; Region: SLBB; pfam10531 866536005819 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 866536005820 SLBB domain; Region: SLBB; pfam10531 866536005821 GxxExxY protein; Region: GxxExxY; TIGR04256 866536005822 Chain length determinant protein; Region: Wzz; pfam02706 866536005823 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 866536005824 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 866536005825 four helix bundle protein; Region: TIGR02436 866536005826 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 866536005827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 866536005828 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 866536005829 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 866536005830 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 866536005831 Putative addiction module component; Region: Unstab_antitox; pfam09720 866536005832 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 866536005833 PemK-like protein; Region: PemK; pfam02452 866536005834 PIN domain; Region: PIN_2; cl17859 866536005835 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 866536005836 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 866536005837 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 866536005838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536005839 AAA domain; Region: AAA_23; pfam13476 866536005840 Walker A/P-loop; other site 866536005841 ATP binding site [chemical binding]; other site 866536005842 Macrophage colony stimulating factor-1 (CSF-1); Region: CSF-1; pfam05337 866536005843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536005844 ABC transporter signature motif; other site 866536005845 Walker B; other site 866536005846 D-loop; other site 866536005847 H-loop/switch region; other site 866536005848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536005849 active site 866536005850 HIGH motif; other site 866536005851 nucleotide binding site [chemical binding]; other site 866536005852 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 866536005853 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 866536005854 NADP binding site [chemical binding]; other site 866536005855 active site 866536005856 putative substrate binding site [chemical binding]; other site 866536005857 GxxExxY protein; Region: GxxExxY; TIGR04256 866536005858 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 866536005859 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 866536005860 NADP-binding site; other site 866536005861 homotetramer interface [polypeptide binding]; other site 866536005862 substrate binding site [chemical binding]; other site 866536005863 homodimer interface [polypeptide binding]; other site 866536005864 active site 866536005865 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 866536005866 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 866536005867 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 866536005868 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536005869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 866536005870 active site 866536005871 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 866536005872 metal-binding site 866536005873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536005874 active site 866536005875 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536005876 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 866536005877 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 866536005878 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 866536005879 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 866536005880 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 866536005881 Cupin domain; Region: Cupin_2; cl17218 866536005882 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536005883 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536005884 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 866536005885 GTP-binding protein YchF; Reviewed; Region: PRK09601 866536005886 YchF GTPase; Region: YchF; cd01900 866536005887 G1 box; other site 866536005888 GTP/Mg2+ binding site [chemical binding]; other site 866536005889 Switch I region; other site 866536005890 G2 box; other site 866536005891 Switch II region; other site 866536005892 G3 box; other site 866536005893 G4 box; other site 866536005894 G5 box; other site 866536005895 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 866536005896 Domain of unknown function DUF20; Region: UPF0118; pfam01594 866536005897 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 866536005898 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 866536005899 4Fe-4S binding domain; Region: Fer4; cl02805 866536005900 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 866536005901 NAD(P) binding site [chemical binding]; other site 866536005902 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 866536005903 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 866536005904 substrate binding site [chemical binding]; other site 866536005905 ligand binding site [chemical binding]; other site 866536005906 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 866536005907 substrate binding site [chemical binding]; other site 866536005908 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 866536005909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536005910 putative active site [active] 866536005911 heme pocket [chemical binding]; other site 866536005912 PAS domain S-box; Region: sensory_box; TIGR00229 866536005913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536005914 putative active site [active] 866536005915 heme pocket [chemical binding]; other site 866536005916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536005917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536005918 dimer interface [polypeptide binding]; other site 866536005919 phosphorylation site [posttranslational modification] 866536005920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536005921 ATP binding site [chemical binding]; other site 866536005922 Mg2+ binding site [ion binding]; other site 866536005923 G-X-G motif; other site 866536005924 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536005925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536005926 active site 866536005927 phosphorylation site [posttranslational modification] 866536005928 intermolecular recognition site; other site 866536005929 dimerization interface [polypeptide binding]; other site 866536005930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005931 TPR repeat; Region: TPR_11; pfam13414 866536005932 binding surface 866536005933 TPR motif; other site 866536005934 TPR repeat; Region: TPR_11; pfam13414 866536005935 TPR repeat; Region: TPR_11; pfam13414 866536005936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005937 binding surface 866536005938 TPR motif; other site 866536005939 TPR repeat; Region: TPR_11; pfam13414 866536005940 TPR repeat; Region: TPR_11; pfam13414 866536005941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005942 binding surface 866536005943 TPR motif; other site 866536005944 TPR repeat; Region: TPR_11; pfam13414 866536005945 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 866536005946 Domain of unknown function DUF20; Region: UPF0118; pfam01594 866536005947 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 866536005948 Cation efflux family; Region: Cation_efflux; pfam01545 866536005949 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 866536005950 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 866536005951 active site 866536005952 Zn binding site [ion binding]; other site 866536005953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 866536005954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536005955 putative DNA binding site [nucleotide binding]; other site 866536005956 putative Zn2+ binding site [ion binding]; other site 866536005957 AsnC family; Region: AsnC_trans_reg; pfam01037 866536005958 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 866536005959 ADP-ribose binding site [chemical binding]; other site 866536005960 dimer interface [polypeptide binding]; other site 866536005961 active site 866536005962 nudix motif; other site 866536005963 metal binding site [ion binding]; metal-binding site 866536005964 multidrug efflux protein; Reviewed; Region: PRK01766 866536005965 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 866536005966 cation binding site [ion binding]; other site 866536005967 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 866536005968 YhhN-like protein; Region: YhhN; pfam07947 866536005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536005970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536005971 putative substrate translocation pore; other site 866536005972 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 866536005973 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 866536005974 homodimer interface [polypeptide binding]; other site 866536005975 substrate-cofactor binding pocket; other site 866536005976 catalytic residue [active] 866536005977 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 866536005978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866536005979 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866536005980 Walker A/P-loop; other site 866536005981 ATP binding site [chemical binding]; other site 866536005982 Q-loop/lid; other site 866536005983 ABC transporter signature motif; other site 866536005984 Walker B; other site 866536005985 D-loop; other site 866536005986 H-loop/switch region; other site 866536005987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536005988 TPR motif; other site 866536005989 binding surface 866536005990 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 866536005991 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866536005992 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 866536005993 putative acyl-acceptor binding pocket; other site 866536005994 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 866536005995 apolar tunnel; other site 866536005996 heme binding site [chemical binding]; other site 866536005997 dimerization interface [polypeptide binding]; other site 866536005998 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 866536005999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 866536006000 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 866536006001 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 866536006002 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 866536006003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 866536006004 carboxyltransferase (CT) interaction site; other site 866536006005 biotinylation site [posttranslational modification]; other site 866536006006 elongation factor P; Validated; Region: PRK00529 866536006007 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 866536006008 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 866536006009 RNA binding site [nucleotide binding]; other site 866536006010 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 866536006011 RNA binding site [nucleotide binding]; other site 866536006012 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 866536006013 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 866536006014 dimer interface [polypeptide binding]; other site 866536006015 active site 866536006016 CoA binding pocket [chemical binding]; other site 866536006017 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 866536006018 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 866536006019 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 866536006020 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 866536006021 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 866536006022 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 866536006023 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 866536006024 MgtE intracellular N domain; Region: MgtE_N; pfam03448 866536006025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 866536006026 Divalent cation transporter; Region: MgtE; pfam01769 866536006027 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 866536006028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536006029 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 866536006030 active site 866536006031 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 866536006032 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 866536006033 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 866536006034 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536006035 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 866536006036 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 866536006037 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 866536006038 NAD(P) binding site [chemical binding]; other site 866536006039 Beta-lactamase; Region: Beta-lactamase; pfam00144 866536006040 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 866536006041 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 866536006042 active site 866536006043 catalytic site [active] 866536006044 substrate binding site [chemical binding]; other site 866536006045 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 866536006046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536006047 replicative DNA helicase; Region: DnaB; TIGR00665 866536006048 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 866536006049 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 866536006050 Walker A motif; other site 866536006051 ATP binding site [chemical binding]; other site 866536006052 Walker B motif; other site 866536006053 DNA binding loops [nucleotide binding] 866536006054 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 866536006055 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 866536006056 NAD(P) binding site [chemical binding]; other site 866536006057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866536006058 TPR motif; other site 866536006059 binding surface 866536006060 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 866536006061 Ligand binding site [chemical binding]; other site 866536006062 Electron transfer flavoprotein domain; Region: ETF; pfam01012 866536006063 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 866536006064 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 866536006065 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 866536006066 Bifunctional nuclease; Region: DNase-RNase; pfam02577 866536006067 UvrB/uvrC motif; Region: UVR; pfam02151 866536006068 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 866536006069 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 866536006070 Nucleoside recognition; Region: Gate; pfam07670 866536006071 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 866536006072 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 866536006073 active site 866536006074 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 866536006075 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 866536006076 active site 866536006077 substrate-binding site [chemical binding]; other site 866536006078 metal-binding site [ion binding] 866536006079 ATP binding site [chemical binding]; other site 866536006080 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 866536006081 POT family; Region: PTR2; cl17359 866536006082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006083 active site 866536006084 phosphorylation site [posttranslational modification] 866536006085 intermolecular recognition site; other site 866536006086 dimerization interface [polypeptide binding]; other site 866536006087 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 866536006088 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 866536006089 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536006090 Ligand Binding Site [chemical binding]; other site 866536006091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536006092 Ligand Binding Site [chemical binding]; other site 866536006093 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 866536006094 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 866536006095 CoA-ligase; Region: Ligase_CoA; pfam00549 866536006096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866536006097 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 866536006098 Walker A/P-loop; other site 866536006099 ATP binding site [chemical binding]; other site 866536006100 Q-loop/lid; other site 866536006101 ABC transporter signature motif; other site 866536006102 Walker B; other site 866536006103 D-loop; other site 866536006104 H-loop/switch region; other site 866536006105 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 866536006106 EamA-like transporter family; Region: EamA; pfam00892 866536006107 CHAT domain; Region: CHAT; pfam12770 866536006108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866536006109 TPR motif; other site 866536006110 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 866536006111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536006112 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 866536006113 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 866536006114 EamA-like transporter family; Region: EamA; pfam00892 866536006115 EamA-like transporter family; Region: EamA; cl17759 866536006116 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 866536006117 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 866536006118 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 866536006119 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 866536006120 glycerol kinase; Provisional; Region: glpK; PRK00047 866536006121 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 866536006122 N- and C-terminal domain interface [polypeptide binding]; other site 866536006123 active site 866536006124 MgATP binding site [chemical binding]; other site 866536006125 catalytic site [active] 866536006126 metal binding site [ion binding]; metal-binding site 866536006127 glycerol binding site [chemical binding]; other site 866536006128 homotetramer interface [polypeptide binding]; other site 866536006129 homodimer interface [polypeptide binding]; other site 866536006130 FBP binding site [chemical binding]; other site 866536006131 protein IIAGlc interface [polypeptide binding]; other site 866536006132 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 866536006133 amphipathic channel; other site 866536006134 Asn-Pro-Ala signature motifs; other site 866536006135 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 866536006136 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 866536006137 active site 866536006138 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 866536006139 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 866536006140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 866536006141 active site 866536006142 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 866536006143 Isochorismatase family; Region: Isochorismatase; pfam00857 866536006144 catalytic triad [active] 866536006145 metal binding site [ion binding]; metal-binding site 866536006146 conserved cis-peptide bond; other site 866536006147 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 866536006148 altronate oxidoreductase; Provisional; Region: PRK03643 866536006149 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 866536006150 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 866536006151 Glucuronate isomerase; Region: UxaC; pfam02614 866536006152 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 866536006153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536006154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536006155 DNA binding site [nucleotide binding] 866536006156 domain linker motif; other site 866536006157 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536006158 dimerization interface [polypeptide binding]; other site 866536006159 ligand binding site [chemical binding]; other site 866536006160 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 866536006161 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 866536006162 NADP binding site [chemical binding]; other site 866536006163 homodimer interface [polypeptide binding]; other site 866536006164 active site 866536006165 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 866536006166 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 866536006167 Pectinesterase; Region: Pectinesterase; pfam01095 866536006168 putative pectinesterase; Region: PLN02432; cl01911 866536006169 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 866536006170 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 866536006171 active site 866536006172 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 866536006173 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 866536006174 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 866536006175 active site 866536006176 catalytic triad [active] 866536006177 Pectate lyase; Region: Pec_lyase_C; cl01593 866536006178 Pectate lyase; Region: Pec_lyase_C; cl01593 866536006179 AAA domain; Region: AAA_14; pfam13173 866536006180 AAA domain; Region: AAA_22; pfam13401 866536006181 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 866536006182 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 866536006183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 866536006184 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 866536006185 toxin interface [polypeptide binding]; other site 866536006186 Zn binding site [ion binding]; other site 866536006187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536006188 dimerization interface [polypeptide binding]; other site 866536006189 putative DNA binding site [nucleotide binding]; other site 866536006190 putative Zn2+ binding site [ion binding]; other site 866536006191 WbqC-like protein family; Region: WbqC; pfam08889 866536006192 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 866536006193 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 866536006194 putative trimer interface [polypeptide binding]; other site 866536006195 putative CoA binding site [chemical binding]; other site 866536006196 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 866536006197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536006198 active site 866536006199 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 866536006200 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 866536006201 inhibitor-cofactor binding pocket; inhibition site 866536006202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536006203 catalytic residue [active] 866536006204 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 866536006205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536006206 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 866536006207 Integrase core domain; Region: rve; pfam00665 866536006208 Integrase core domain; Region: rve_3; pfam13683 866536006209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536006210 Transposase; Region: HTH_Tnp_1; cl17663 866536006211 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 866536006212 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 866536006213 Walker A/P-loop; other site 866536006214 ATP binding site [chemical binding]; other site 866536006215 Q-loop/lid; other site 866536006216 ABC transporter signature motif; other site 866536006217 Walker B; other site 866536006218 D-loop; other site 866536006219 H-loop/switch region; other site 866536006220 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 866536006221 trimer interface [polypeptide binding]; other site 866536006222 active site 866536006223 substrate binding site [chemical binding]; other site 866536006224 CoA binding site [chemical binding]; other site 866536006225 Methyltransferase domain; Region: Methyltransf_24; pfam13578 866536006226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536006227 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 866536006228 active site 866536006229 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 866536006230 Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572 866536006231 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 866536006232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536006233 active site 866536006234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536006235 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 866536006236 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 866536006237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 866536006238 active site 866536006239 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 866536006240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536006241 active site 866536006242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536006243 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 866536006244 putative ADP-binding pocket [chemical binding]; other site 866536006245 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 866536006246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536006247 Coenzyme A binding pocket [chemical binding]; other site 866536006248 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 866536006249 active site 866536006250 NTP binding site [chemical binding]; other site 866536006251 metal binding triad [ion binding]; metal-binding site 866536006252 antibiotic binding site [chemical binding]; other site 866536006253 Protein of unknown function DUF86; Region: DUF86; cl01031 866536006254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536006255 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 866536006256 putative ADP-binding pocket [chemical binding]; other site 866536006257 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536006258 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536006259 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 866536006260 active site 866536006261 catalytic triad [active] 866536006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536006263 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 866536006264 Walker A motif; other site 866536006265 ATP binding site [chemical binding]; other site 866536006266 Walker B motif; other site 866536006267 arginine finger; other site 866536006268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 866536006269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536006270 non-specific DNA binding site [nucleotide binding]; other site 866536006271 salt bridge; other site 866536006272 sequence-specific DNA binding site [nucleotide binding]; other site 866536006273 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536006274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006275 active site 866536006276 phosphorylation site [posttranslational modification] 866536006277 intermolecular recognition site; other site 866536006278 dimerization interface [polypeptide binding]; other site 866536006279 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536006280 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536006281 Transposase; Region: HTH_Tnp_1; cl17663 866536006282 Integrase core domain; Region: rve; pfam00665 866536006283 Integrase core domain; Region: rve_3; pfam13683 866536006284 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536006285 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536006286 catalytic residues [active] 866536006287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536006288 non-specific DNA binding site [nucleotide binding]; other site 866536006289 salt bridge; other site 866536006290 sequence-specific DNA binding site [nucleotide binding]; other site 866536006291 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 866536006292 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 866536006293 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536006294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536006295 Walker A motif; other site 866536006296 ATP binding site [chemical binding]; other site 866536006297 Walker B motif; other site 866536006298 arginine finger; other site 866536006299 Homeodomain-like domain; Region: HTH_23; pfam13384 866536006300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536006301 Integrase core domain; Region: rve; pfam00665 866536006302 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 866536006303 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536006304 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 866536006305 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 866536006306 active site 866536006307 interdomain interaction site; other site 866536006308 putative metal-binding site [ion binding]; other site 866536006309 nucleotide binding site [chemical binding]; other site 866536006310 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 866536006311 domain I; other site 866536006312 DNA binding groove [nucleotide binding] 866536006313 phosphate binding site [ion binding]; other site 866536006314 domain II; other site 866536006315 domain III; other site 866536006316 nucleotide binding site [chemical binding]; other site 866536006317 catalytic site [active] 866536006318 domain IV; other site 866536006319 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 866536006320 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 866536006321 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 866536006322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 866536006323 catalytic core [active] 866536006324 agmatinase; Region: agmatinase; TIGR01230 866536006325 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 866536006326 putative active site [active] 866536006327 Mn binding site [ion binding]; other site 866536006328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 866536006329 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 866536006330 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 866536006331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 866536006332 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 866536006333 active site 866536006334 catalytic tetrad [active] 866536006335 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 866536006336 catalytic site [active] 866536006337 SnoaL-like domain; Region: SnoaL_3; pfam13474 866536006338 Helix-turn-helix domain; Region: HTH_18; pfam12833 866536006339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536006340 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 866536006341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536006342 catalytic loop [active] 866536006343 iron binding site [ion binding]; other site 866536006344 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 866536006345 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 866536006346 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 866536006347 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536006348 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536006349 FeoA domain; Region: FeoA; pfam04023 866536006350 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 866536006351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 866536006352 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 866536006353 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866536006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006355 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536006356 active site 866536006357 phosphorylation site [posttranslational modification] 866536006358 intermolecular recognition site; other site 866536006359 dimerization interface [polypeptide binding]; other site 866536006360 Response regulator receiver domain; Region: Response_reg; pfam00072 866536006361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006362 active site 866536006363 phosphorylation site [posttranslational modification] 866536006364 intermolecular recognition site; other site 866536006365 dimerization interface [polypeptide binding]; other site 866536006366 PAS domain S-box; Region: sensory_box; TIGR00229 866536006367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006368 putative active site [active] 866536006369 heme pocket [chemical binding]; other site 866536006370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006371 phosphorylation site [posttranslational modification] 866536006372 dimer interface [polypeptide binding]; other site 866536006373 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536006374 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536006375 Response regulator receiver domain; Region: Response_reg; pfam00072 866536006376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006377 active site 866536006378 phosphorylation site [posttranslational modification] 866536006379 intermolecular recognition site; other site 866536006380 dimerization interface [polypeptide binding]; other site 866536006381 Response regulator receiver domain; Region: Response_reg; pfam00072 866536006382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006383 active site 866536006384 phosphorylation site [posttranslational modification] 866536006385 intermolecular recognition site; other site 866536006386 dimerization interface [polypeptide binding]; other site 866536006387 Response regulator receiver domain; Region: Response_reg; pfam00072 866536006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536006389 active site 866536006390 phosphorylation site [posttranslational modification] 866536006391 intermolecular recognition site; other site 866536006392 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536006393 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536006394 PAS fold; Region: PAS_3; pfam08447 866536006395 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 866536006396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006397 PAS domain; Region: PAS_9; pfam13426 866536006398 putative active site [active] 866536006399 heme pocket [chemical binding]; other site 866536006400 PAS fold; Region: PAS_4; pfam08448 866536006401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006402 putative active site [active] 866536006403 heme pocket [chemical binding]; other site 866536006404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006405 dimer interface [polypeptide binding]; other site 866536006406 phosphorylation site [posttranslational modification] 866536006407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006408 ATP binding site [chemical binding]; other site 866536006409 Mg2+ binding site [ion binding]; other site 866536006410 G-X-G motif; other site 866536006411 PAS domain; Region: PAS_9; pfam13426 866536006412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006413 putative active site [active] 866536006414 heme pocket [chemical binding]; other site 866536006415 PAS domain; Region: PAS; smart00091 866536006416 putative active site [active] 866536006417 PAS fold; Region: PAS_3; pfam08447 866536006418 PAS fold; Region: PAS_4; pfam08448 866536006419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 866536006420 putative active site [active] 866536006421 heme pocket [chemical binding]; other site 866536006422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006423 PAS fold; Region: PAS_3; pfam08447 866536006424 putative active site [active] 866536006425 heme pocket [chemical binding]; other site 866536006426 PAS domain S-box; Region: sensory_box; TIGR00229 866536006427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006428 putative active site [active] 866536006429 heme pocket [chemical binding]; other site 866536006430 PAS domain S-box; Region: sensory_box; TIGR00229 866536006431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006432 putative active site [active] 866536006433 heme pocket [chemical binding]; other site 866536006434 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 866536006435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006436 putative active site [active] 866536006437 heme pocket [chemical binding]; other site 866536006438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006439 dimer interface [polypeptide binding]; other site 866536006440 phosphorylation site [posttranslational modification] 866536006441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006442 ATP binding site [chemical binding]; other site 866536006443 Mg2+ binding site [ion binding]; other site 866536006444 G-X-G motif; other site 866536006445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006446 dimer interface [polypeptide binding]; other site 866536006447 phosphorylation site [posttranslational modification] 866536006448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006449 ATP binding site [chemical binding]; other site 866536006450 Mg2+ binding site [ion binding]; other site 866536006451 G-X-G motif; other site 866536006452 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 866536006453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 866536006454 PAS fold; Region: PAS_3; pfam08447 866536006455 putative active site [active] 866536006456 heme pocket [chemical binding]; other site 866536006457 PAS domain S-box; Region: sensory_box; TIGR00229 866536006458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006459 dimer interface [polypeptide binding]; other site 866536006460 phosphorylation site [posttranslational modification] 866536006461 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 866536006462 CheB methylesterase; Region: CheB_methylest; pfam01339 866536006463 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 866536006464 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 866536006465 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 866536006466 PAS domain; Region: PAS_9; pfam13426 866536006467 PAS domain S-box; Region: sensory_box; TIGR00229 866536006468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006469 putative active site [active] 866536006470 heme pocket [chemical binding]; other site 866536006471 PAS fold; Region: PAS_3; pfam08447 866536006472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006473 putative active site [active] 866536006474 heme pocket [chemical binding]; other site 866536006475 PAS domain S-box; Region: sensory_box; TIGR00229 866536006476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006477 putative active site [active] 866536006478 heme pocket [chemical binding]; other site 866536006479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006480 putative active site [active] 866536006481 PAS fold; Region: PAS_3; pfam08447 866536006482 heme pocket [chemical binding]; other site 866536006483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006484 dimer interface [polypeptide binding]; other site 866536006485 phosphorylation site [posttranslational modification] 866536006486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006487 ATP binding site [chemical binding]; other site 866536006488 Mg2+ binding site [ion binding]; other site 866536006489 G-X-G motif; other site 866536006490 PAS fold; Region: PAS_3; pfam08447 866536006491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006492 PAS fold; Region: PAS_3; pfam08447 866536006493 putative active site [active] 866536006494 heme pocket [chemical binding]; other site 866536006495 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 866536006496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006497 putative active site [active] 866536006498 heme pocket [chemical binding]; other site 866536006499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 866536006500 GAF domain; Region: GAF; pfam01590 866536006501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006502 dimer interface [polypeptide binding]; other site 866536006503 phosphorylation site [posttranslational modification] 866536006504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006505 ATP binding site [chemical binding]; other site 866536006506 Mg2+ binding site [ion binding]; other site 866536006507 G-X-G motif; other site 866536006508 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536006509 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536006510 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536006511 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 866536006512 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 866536006513 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 866536006514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 866536006515 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 866536006516 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 866536006517 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 866536006518 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 866536006519 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 866536006520 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 866536006521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536006522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 866536006523 dimer interface [polypeptide binding]; other site 866536006524 phosphorylation site [posttranslational modification] 866536006525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006526 ATP binding site [chemical binding]; other site 866536006527 Mg2+ binding site [ion binding]; other site 866536006528 G-X-G motif; other site 866536006529 PAS fold; Region: PAS_3; pfam08447 866536006530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006531 putative active site [active] 866536006532 heme pocket [chemical binding]; other site 866536006533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006534 PAS fold; Region: PAS_3; pfam08447 866536006535 putative active site [active] 866536006536 heme pocket [chemical binding]; other site 866536006537 GAF domain; Region: GAF_2; pfam13185 866536006538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536006539 PAS fold; Region: PAS_3; pfam08447 866536006540 putative active site [active] 866536006541 heme pocket [chemical binding]; other site 866536006542 PAS fold; Region: PAS_3; pfam08447 866536006543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536006544 dimer interface [polypeptide binding]; other site 866536006545 phosphorylation site [posttranslational modification] 866536006546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006547 ATP binding site [chemical binding]; other site 866536006548 Mg2+ binding site [ion binding]; other site 866536006549 G-X-G motif; other site 866536006550 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536006551 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 866536006552 apical/protease domain interface [polypeptide binding]; other site 866536006553 substrate binding [chemical binding]; other site 866536006554 dimer interface [polypeptide binding]; other site 866536006555 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 866536006556 dimer interface [polypeptide binding]; other site 866536006557 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536006558 active site 866536006559 metal binding site [ion binding]; metal-binding site 866536006560 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 866536006561 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 866536006562 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 866536006563 active site 866536006564 ADP/pyrophosphate binding site [chemical binding]; other site 866536006565 dimerization interface [polypeptide binding]; other site 866536006566 allosteric effector site; other site 866536006567 fructose-1,6-bisphosphate binding site; other site 866536006568 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 866536006569 Esterase/lipase [General function prediction only]; Region: COG1647 866536006570 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 866536006571 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536006572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 866536006573 ligand binding site [chemical binding]; other site 866536006574 flexible hinge region; other site 866536006575 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 866536006576 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536006577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536006578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866536006579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536006580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536006581 Walker A/P-loop; other site 866536006582 ATP binding site [chemical binding]; other site 866536006583 Q-loop/lid; other site 866536006584 ABC transporter signature motif; other site 866536006585 Walker B; other site 866536006586 D-loop; other site 866536006587 H-loop/switch region; other site 866536006588 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 866536006589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536006590 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536006591 Outer membrane efflux protein; Region: OEP; pfam02321 866536006592 Outer membrane efflux protein; Region: OEP; pfam02321 866536006593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536006594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536006595 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 866536006596 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 866536006597 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 866536006598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536006599 Coenzyme A binding pocket [chemical binding]; other site 866536006600 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536006601 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 866536006602 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 866536006603 Catalytic dyad [active] 866536006604 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 866536006605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536006606 Walker A/P-loop; other site 866536006607 ATP binding site [chemical binding]; other site 866536006608 Q-loop/lid; other site 866536006609 ABC transporter signature motif; other site 866536006610 Walker B; other site 866536006611 D-loop; other site 866536006612 H-loop/switch region; other site 866536006613 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 866536006614 active site 866536006615 intersubunit interactions; other site 866536006616 catalytic residue [active] 866536006617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 866536006618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 866536006619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536006620 Walker A/P-loop; other site 866536006621 ATP binding site [chemical binding]; other site 866536006622 Q-loop/lid; other site 866536006623 ABC transporter signature motif; other site 866536006624 Walker B; other site 866536006625 D-loop; other site 866536006626 H-loop/switch region; other site 866536006627 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866536006628 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536006629 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 866536006630 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 866536006631 motif 1; other site 866536006632 active site 866536006633 motif 2; other site 866536006634 motif 3; other site 866536006635 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 866536006636 DHHA1 domain; Region: DHHA1; pfam02272 866536006637 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 866536006638 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 866536006639 GatB domain; Region: GatB_Yqey; smart00845 866536006640 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 866536006641 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536006642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536006643 catalytic residues [active] 866536006644 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 866536006645 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 866536006646 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 866536006647 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 866536006648 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 866536006649 integral membrane protein; Region: integ_memb_HG; TIGR03954 866536006650 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 866536006651 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 866536006652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536006653 S-adenosylmethionine binding site [chemical binding]; other site 866536006654 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 866536006655 Lumazine binding domain; Region: Lum_binding; pfam00677 866536006656 Lumazine binding domain; Region: Lum_binding; pfam00677 866536006657 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 866536006658 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 866536006659 active site 866536006660 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 866536006661 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 866536006662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 866536006663 phosphate binding site [ion binding]; other site 866536006664 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 866536006665 active site 866536006666 catalytic triad [active] 866536006667 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536006668 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 866536006669 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 866536006670 substrate binding site [chemical binding]; other site 866536006671 hexamer interface [polypeptide binding]; other site 866536006672 metal binding site [ion binding]; metal-binding site 866536006673 26S proteasome subunit P45 family; Region: 26Sp45; TIGR01242 866536006674 DNA gyrase subunit A; Validated; Region: PRK05560 866536006675 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 866536006676 CAP-like domain; other site 866536006677 active site 866536006678 primary dimer interface [polypeptide binding]; other site 866536006679 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006680 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006681 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006682 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006683 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006684 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 866536006685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536006686 TPR motif; other site 866536006687 binding surface 866536006688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536006689 Tetratricopeptide repeat; Region: TPR_16; pfam13432 866536006690 TPR motif; other site 866536006691 binding surface 866536006692 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 866536006693 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 866536006694 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 866536006695 Na binding site [ion binding]; other site 866536006696 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 866536006697 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536006698 putative metal binding site [ion binding]; other site 866536006699 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 866536006700 Interdomain contacts; other site 866536006701 DinB superfamily; Region: DinB_2; pfam12867 866536006702 YceI-like domain; Region: YceI; pfam04264 866536006703 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 866536006704 Lyase; Region: Lyase_1; pfam00206 866536006705 active sites [active] 866536006706 tetramer interface [polypeptide binding]; other site 866536006707 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 866536006708 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 866536006709 metal binding site [ion binding]; metal-binding site 866536006710 dimer interface [polypeptide binding]; other site 866536006711 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 866536006712 nucleotide binding site [chemical binding]; other site 866536006713 N-acetyl-L-glutamate binding site [chemical binding]; other site 866536006714 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 866536006715 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 866536006716 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 866536006717 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 866536006718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866536006719 inhibitor-cofactor binding pocket; inhibition site 866536006720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536006721 catalytic residue [active] 866536006722 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 866536006723 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 866536006724 argininosuccinate synthase; Provisional; Region: PRK13820 866536006725 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 866536006726 Ligand Binding Site [chemical binding]; other site 866536006727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 866536006728 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 866536006729 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 866536006730 catalytic residues [active] 866536006731 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 866536006732 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 866536006733 THF binding site; other site 866536006734 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 866536006735 substrate binding site [chemical binding]; other site 866536006736 THF binding site; other site 866536006737 zinc-binding site [ion binding]; other site 866536006738 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 866536006739 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 866536006740 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 866536006741 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 866536006742 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 866536006743 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 866536006744 Uncharacterized conserved protein [Function unknown]; Region: COG3595 866536006745 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 866536006746 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536006747 cofactor binding site; other site 866536006748 DNA binding site [nucleotide binding] 866536006749 substrate interaction site [chemical binding]; other site 866536006750 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536006751 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 866536006752 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 866536006753 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 866536006754 SelR domain; Region: SelR; pfam01641 866536006755 Penicillin amidase; Region: Penicil_amidase; pfam01804 866536006756 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536006757 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 866536006758 active site 866536006759 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 866536006760 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 866536006761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 866536006762 inhibitor-cofactor binding pocket; inhibition site 866536006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536006764 catalytic residue [active] 866536006765 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 866536006766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536006767 S-adenosylmethionine binding site [chemical binding]; other site 866536006768 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 866536006769 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536006770 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536006771 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 866536006772 short chain dehydrogenase; Provisional; Region: PRK06197 866536006773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536006774 NAD(P) binding site [chemical binding]; other site 866536006775 active site 866536006776 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 866536006777 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866536006778 putative acyl-acceptor binding pocket; other site 866536006779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 866536006780 CoA binding domain; Region: CoA_binding_2; pfam13380 866536006781 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 866536006782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536006783 ATP binding site [chemical binding]; other site 866536006784 Mg2+ binding site [ion binding]; other site 866536006785 G-X-G motif; other site 866536006786 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 866536006787 anchoring element; other site 866536006788 dimer interface [polypeptide binding]; other site 866536006789 ATP binding site [chemical binding]; other site 866536006790 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 866536006791 active site 866536006792 putative metal-binding site [ion binding]; other site 866536006793 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 866536006794 polyphosphate kinase; Provisional; Region: PRK05443 866536006795 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 866536006796 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 866536006797 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 866536006798 putative domain interface [polypeptide binding]; other site 866536006799 putative active site [active] 866536006800 catalytic site [active] 866536006801 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 866536006802 putative domain interface [polypeptide binding]; other site 866536006803 putative active site [active] 866536006804 catalytic site [active] 866536006805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 866536006806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 866536006807 Domain of unknown function (DUF202); Region: DUF202; pfam02656 866536006808 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 866536006809 catalytic motif [active] 866536006810 Zn binding site [ion binding]; other site 866536006811 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 866536006812 FAD binding domain; Region: FAD_binding_4; pfam01565 866536006813 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 866536006814 Predicted deacylase [General function prediction only]; Region: COG3608 866536006815 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 866536006816 putative active site [active] 866536006817 Zn binding site [ion binding]; other site 866536006818 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 866536006819 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536006820 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 866536006821 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 866536006822 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 866536006823 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 866536006824 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 866536006825 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 866536006826 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 866536006827 active site 866536006828 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 866536006829 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 866536006830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 866536006831 FeS/SAM binding site; other site 866536006832 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 866536006833 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 866536006834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 866536006835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536006836 S-adenosylmethionine binding site [chemical binding]; other site 866536006837 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 866536006838 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 866536006839 Probable Catalytic site; other site 866536006840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536006841 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 866536006842 active site 866536006843 metal binding site [ion binding]; metal-binding site 866536006844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 866536006845 active site 866536006846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536006847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536006848 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536006849 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 866536006850 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 866536006851 metal binding site [ion binding]; metal-binding site 866536006852 putative dimer interface [polypeptide binding]; other site 866536006853 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 866536006854 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 866536006855 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 866536006856 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866536006857 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 866536006858 Uncharacterized conserved protein [Function unknown]; Region: COG1359 866536006859 Predicted dehydrogenase [General function prediction only]; Region: COG0579 866536006860 hydroxyglutarate oxidase; Provisional; Region: PRK11728 866536006861 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 866536006862 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 866536006863 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 866536006864 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 866536006865 active site 866536006866 dimer interface [polypeptide binding]; other site 866536006867 motif 1; other site 866536006868 motif 2; other site 866536006869 motif 3; other site 866536006870 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 866536006871 anticodon binding site; other site 866536006872 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 866536006873 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 866536006874 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 866536006875 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 866536006876 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 866536006877 23S rRNA binding site [nucleotide binding]; other site 866536006878 L21 binding site [polypeptide binding]; other site 866536006879 L13 binding site [polypeptide binding]; other site 866536006880 Predicted permeases [General function prediction only]; Region: COG0795 866536006881 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 866536006882 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 866536006883 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 866536006884 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 866536006885 16S/18S rRNA binding site [nucleotide binding]; other site 866536006886 S13e-L30e interaction site [polypeptide binding]; other site 866536006887 25S rRNA binding site [nucleotide binding]; other site 866536006888 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 866536006889 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 866536006890 RNase E interface [polypeptide binding]; other site 866536006891 trimer interface [polypeptide binding]; other site 866536006892 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 866536006893 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 866536006894 RNase E interface [polypeptide binding]; other site 866536006895 trimer interface [polypeptide binding]; other site 866536006896 active site 866536006897 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 866536006898 putative nucleic acid binding region [nucleotide binding]; other site 866536006899 G-X-X-G motif; other site 866536006900 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 866536006901 RNA binding site [nucleotide binding]; other site 866536006902 domain interface; other site 866536006903 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 866536006904 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 866536006905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536006906 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 866536006907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536006908 DNA binding residues [nucleotide binding] 866536006909 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 866536006910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866536006911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536006912 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866536006913 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536006914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 866536006915 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 866536006916 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 866536006917 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 866536006918 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 866536006919 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 866536006920 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536006921 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536006922 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536006923 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536006924 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 866536006925 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 866536006926 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 866536006927 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 866536006928 NADH(P)-binding; Region: NAD_binding_10; pfam13460 866536006929 NAD binding site [chemical binding]; other site 866536006930 substrate binding site [chemical binding]; other site 866536006931 putative active site [active] 866536006932 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 866536006933 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 866536006934 NADP binding site [chemical binding]; other site 866536006935 DoxX-like family; Region: DoxX_2; pfam13564 866536006936 Predicted transcriptional regulators [Transcription]; Region: COG1733 866536006937 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 866536006938 Restriction endonuclease; Region: Mrr_cat; pfam04471 866536006939 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536006940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536006941 Walker A motif; other site 866536006942 ATP binding site [chemical binding]; other site 866536006943 Walker B motif; other site 866536006944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536006945 Integrase core domain; Region: rve; pfam00665 866536006946 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 866536006947 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 866536006948 NADP binding site [chemical binding]; other site 866536006949 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 866536006950 Putative transposase; Region: Y2_Tnp; pfam04986 866536006951 SnoaL-like domain; Region: SnoaL_2; pfam12680 866536006952 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 866536006953 DoxX-like family; Region: DoxX_2; pfam13564 866536006954 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 866536006955 NADH(P)-binding; Region: NAD_binding_10; pfam13460 866536006956 NAD binding site [chemical binding]; other site 866536006957 substrate binding site [chemical binding]; other site 866536006958 putative active site [active] 866536006959 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 866536006960 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 866536006961 putative active site [active] 866536006962 metal binding site [ion binding]; metal-binding site 866536006963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 866536006964 CoenzymeA binding site [chemical binding]; other site 866536006965 subunit interaction site [polypeptide binding]; other site 866536006966 PHB binding site; other site 866536006967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536006968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 866536006969 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536006970 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536006971 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536006972 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536006973 Protein export membrane protein; Region: SecD_SecF; cl14618 866536006974 Protein export membrane protein; Region: SecD_SecF; cl14618 866536006975 Outer membrane efflux protein; Region: OEP; pfam02321 866536006976 Outer membrane efflux protein; Region: OEP; pfam02321 866536006977 hypothetical protein; Provisional; Region: PRK10279 866536006978 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 866536006979 active site 866536006980 nucleophile elbow; other site 866536006981 putative transposase OrfB; Reviewed; Region: PHA02517 866536006982 HTH-like domain; Region: HTH_21; pfam13276 866536006983 Integrase core domain; Region: rve; pfam00665 866536006984 Integrase core domain; Region: rve_3; pfam13683 866536006985 Transposase; Region: HTH_Tnp_1; cl17663 866536006986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536006987 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 866536006988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536006989 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 866536006990 active site 866536006991 DNA binding site [nucleotide binding] 866536006992 Int/Topo IB signature motif; other site 866536006993 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536006994 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 866536006995 DNA-binding site [nucleotide binding]; DNA binding site 866536006996 RNA-binding motif; other site 866536006997 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 866536006998 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 866536006999 XdhC Rossmann domain; Region: XdhC_C; pfam13478 866536007000 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 866536007001 Ligand binding site; other site 866536007002 metal-binding site 866536007003 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 866536007004 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 866536007005 putative active site [active] 866536007006 Zn binding site [ion binding]; other site 866536007007 B12 binding domain; Region: B12-binding; pfam02310 866536007008 B12 binding site [chemical binding]; other site 866536007009 Radical SAM superfamily; Region: Radical_SAM; pfam04055 866536007010 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 866536007011 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 866536007012 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 866536007013 flavoprotein, HI0933 family; Region: TIGR00275 866536007014 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 866536007015 Zonular occludens toxin (Zot); Region: Zot; cl17485 866536007016 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 866536007017 Tetratricopeptide repeat; Region: TPR_16; pfam13432 866536007018 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 866536007019 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 866536007020 Zn binding sites [ion binding]; other site 866536007021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007022 binding surface 866536007023 Tetratricopeptide repeat; Region: TPR_16; pfam13432 866536007024 TPR motif; other site 866536007025 TPR repeat; Region: TPR_11; pfam13414 866536007026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007027 binding surface 866536007028 TPR motif; other site 866536007029 TPR repeat; Region: TPR_11; pfam13414 866536007030 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 866536007031 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 866536007032 trimer interface [polypeptide binding]; other site 866536007033 active site 866536007034 substrate binding site [chemical binding]; other site 866536007035 CoA binding site [chemical binding]; other site 866536007036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536007037 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 866536007038 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 866536007039 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 866536007040 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 866536007041 FeoA domain; Region: FeoA; pfam04023 866536007042 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 866536007043 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 866536007044 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 866536007045 trmE is a tRNA modification GTPase; Region: trmE; cd04164 866536007046 G1 box; other site 866536007047 GTP/Mg2+ binding site [chemical binding]; other site 866536007048 Switch I region; other site 866536007049 G2 box; other site 866536007050 Switch II region; other site 866536007051 G3 box; other site 866536007052 G4 box; other site 866536007053 G5 box; other site 866536007054 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 866536007055 DNA binding domain, excisionase family; Region: excise; TIGR01764 866536007056 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 866536007057 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 866536007058 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 866536007059 Int/Topo IB signature motif; other site 866536007060 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536007061 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536007062 VirE N-terminal domain; Region: VirE_N; pfam08800 866536007063 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 866536007064 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 866536007065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536007066 non-specific DNA binding site [nucleotide binding]; other site 866536007067 salt bridge; other site 866536007068 sequence-specific DNA binding site [nucleotide binding]; other site 866536007069 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 866536007070 DNA methylase; Region: N6_N4_Mtase; cl17433 866536007071 DNA methylase; Region: N6_N4_Mtase; cl17433 866536007072 Fic/DOC family; Region: Fic; cl00960 866536007073 DEAD-like helicases superfamily; Region: DEXDc; smart00487 866536007074 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 866536007075 5' RNA guide strand anchoring site; other site 866536007076 active site 866536007077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 866536007078 metal binding site 2 [ion binding]; metal-binding site 866536007079 putative DNA binding helix; other site 866536007080 metal binding site 1 [ion binding]; metal-binding site 866536007081 dimer interface [polypeptide binding]; other site 866536007082 structural Zn2+ binding site [ion binding]; other site 866536007083 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 866536007084 Outer membrane efflux protein; Region: OEP; pfam02321 866536007085 Outer membrane efflux protein; Region: OEP; pfam02321 866536007086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536007087 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 866536007088 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536007089 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 866536007090 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 866536007091 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 866536007092 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 866536007093 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 866536007094 putative homotetramer interface [polypeptide binding]; other site 866536007095 putative homodimer interface [polypeptide binding]; other site 866536007096 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 866536007097 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 866536007098 dimerization interface [polypeptide binding]; other site 866536007099 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007100 metal-binding site [ion binding] 866536007101 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 866536007102 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007103 metal-binding site [ion binding] 866536007104 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536007105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536007106 motif II; other site 866536007107 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007108 metal-binding site [ion binding] 866536007109 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007110 metal-binding site [ion binding] 866536007111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536007112 dimerization interface [polypeptide binding]; other site 866536007113 putative DNA binding site [nucleotide binding]; other site 866536007114 putative Zn2+ binding site [ion binding]; other site 866536007115 MerT mercuric transport protein; Region: MerT; cl03578 866536007116 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007117 metal-binding site [ion binding] 866536007118 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007119 metal-binding site [ion binding] 866536007120 Alkylmercury lyase; Region: MerB; pfam03243 866536007121 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 866536007122 metal-binding site [ion binding] 866536007123 mercuric reductase; Region: MerA; TIGR02053 866536007124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536007125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 866536007126 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007128 binding surface 866536007129 TPR motif; other site 866536007130 TPR repeat; Region: TPR_11; pfam13414 866536007131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536007133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536007134 dimer interface [polypeptide binding]; other site 866536007135 phosphorylation site [posttranslational modification] 866536007136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007137 ATP binding site [chemical binding]; other site 866536007138 Mg2+ binding site [ion binding]; other site 866536007139 G-X-G motif; other site 866536007140 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 866536007141 CHY zinc finger; Region: zf-CHY; pfam05495 866536007142 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 866536007143 Na2 binding site [ion binding]; other site 866536007144 substrate binding site 1 [chemical binding]; other site 866536007145 Na binding site 1 [ion binding]; other site 866536007146 substrate binding site 2 [chemical binding]; other site 866536007147 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 866536007148 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536007149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536007150 active site 866536007151 phosphorylation site [posttranslational modification] 866536007152 intermolecular recognition site; other site 866536007153 dimerization interface [polypeptide binding]; other site 866536007154 LytTr DNA-binding domain; Region: LytTR; smart00850 866536007155 Two component regulator propeller; Region: Reg_prop; pfam07494 866536007156 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536007157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536007158 Histidine kinase; Region: His_kinase; pfam06580 866536007159 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 866536007160 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 866536007161 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 866536007162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536007163 Coenzyme A binding pocket [chemical binding]; other site 866536007164 Uncharacterized conserved protein [Function unknown]; Region: COG0397 866536007165 hypothetical protein; Validated; Region: PRK00029 866536007166 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 866536007167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866536007168 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 866536007169 active site 866536007170 metal binding site [ion binding]; metal-binding site 866536007171 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 866536007172 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 866536007173 nucleotide binding site [chemical binding]; other site 866536007174 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536007175 active site 866536007176 Zn binding site [ion binding]; other site 866536007177 hypothetical protein; Provisional; Region: PRK09256 866536007178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 866536007179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536007180 Coenzyme A binding pocket [chemical binding]; other site 866536007181 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536007182 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536007183 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536007184 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536007185 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 866536007186 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 866536007187 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 866536007188 active site 866536007189 catalytic site [active] 866536007190 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 866536007191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536007192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536007193 DNA binding site [nucleotide binding] 866536007194 domain linker motif; other site 866536007195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536007196 dimerization interface [polypeptide binding]; other site 866536007197 ligand binding site [chemical binding]; other site 866536007198 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 866536007199 putative active site [active] 866536007200 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 866536007201 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 866536007202 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 866536007203 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 866536007204 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536007205 Predicted transcriptional regulator [Transcription]; Region: COG2378 866536007206 HTH domain; Region: HTH_11; pfam08279 866536007207 WYL domain; Region: WYL; pfam13280 866536007208 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 866536007209 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 866536007210 Walker A/P-loop; other site 866536007211 ATP binding site [chemical binding]; other site 866536007212 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 866536007213 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 866536007214 ABC transporter signature motif; other site 866536007215 Walker B; other site 866536007216 D-loop; other site 866536007217 H-loop/switch region; other site 866536007218 Cupin domain; Region: Cupin_2; cl17218 866536007219 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 866536007220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 866536007221 catalytic residues [active] 866536007222 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 866536007223 Sodium Bile acid symporter family; Region: SBF; cl17470 866536007224 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 866536007225 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866536007226 putative acyl-acceptor binding pocket; other site 866536007227 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 866536007228 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 866536007229 dimer interface [polypeptide binding]; other site 866536007230 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 866536007231 active site 866536007232 Fe binding site [ion binding]; other site 866536007233 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 866536007234 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 866536007235 active site 866536007236 substrate binding site [chemical binding]; other site 866536007237 metal binding site [ion binding]; metal-binding site 866536007238 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 866536007239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 866536007240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 866536007241 active site 866536007242 catalytic tetrad [active] 866536007243 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 866536007244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536007245 NAD(P) binding site [chemical binding]; other site 866536007246 active site 866536007247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 866536007248 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 866536007249 Beta-lactamase; Region: Beta-lactamase; pfam00144 866536007250 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 866536007251 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 866536007252 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 866536007253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536007254 catalytic residue [active] 866536007255 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 866536007256 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536007257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 866536007258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536007259 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536007260 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 866536007261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536007262 catalytic loop [active] 866536007263 iron binding site [ion binding]; other site 866536007264 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 866536007265 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536007266 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536007267 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 866536007268 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536007269 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 866536007270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536007271 ATP binding site [chemical binding]; other site 866536007272 putative Mg++ binding site [ion binding]; other site 866536007273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536007274 nucleotide binding region [chemical binding]; other site 866536007275 ATP-binding site [chemical binding]; other site 866536007276 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 866536007277 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 866536007278 Predicted acyl esterases [General function prediction only]; Region: COG2936 866536007279 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 866536007280 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 866536007281 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 866536007282 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 866536007283 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 866536007284 CAP-like domain; other site 866536007285 active site 866536007286 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 866536007287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007288 ATP binding site [chemical binding]; other site 866536007289 Mg2+ binding site [ion binding]; other site 866536007290 G-X-G motif; other site 866536007291 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 866536007292 ATP binding site [chemical binding]; other site 866536007293 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 866536007294 active site 866536007295 putative metal-binding site [ion binding]; other site 866536007296 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 866536007297 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 866536007298 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 866536007299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 866536007300 nucleotide binding site [chemical binding]; other site 866536007301 Flagellin N-methylase; Region: FliB; pfam03692 866536007302 ArsC family; Region: ArsC; pfam03960 866536007303 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 866536007304 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 866536007305 S1 domain; Region: S1_2; pfam13509 866536007306 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866536007307 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 866536007308 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 866536007309 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 866536007310 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 866536007311 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 866536007312 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 866536007313 Substrate-binding site [chemical binding]; other site 866536007314 Substrate specificity [chemical binding]; other site 866536007315 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 866536007316 Rhomboid family; Region: Rhomboid; cl11446 866536007317 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 866536007318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866536007319 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536007320 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 866536007321 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 866536007322 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 866536007323 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536007324 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 866536007325 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 866536007326 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 866536007327 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 866536007328 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 866536007329 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 866536007330 active site 866536007331 catalytic triad [active] 866536007332 calcium binding site 1 [ion binding]; other site 866536007333 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536007334 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 866536007335 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536007336 ATP-dependent DNA ligase; Validated; Region: PRK09247 866536007337 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 866536007338 active site 866536007339 DNA binding site [nucleotide binding] 866536007340 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 866536007341 DNA binding site [nucleotide binding] 866536007342 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 866536007343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866536007344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536007345 ATP binding site [chemical binding]; other site 866536007346 putative Mg++ binding site [ion binding]; other site 866536007347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536007348 nucleotide binding region [chemical binding]; other site 866536007349 ATP-binding site [chemical binding]; other site 866536007350 DEAD/H associated; Region: DEAD_assoc; pfam08494 866536007351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007353 binding surface 866536007354 TPR motif; other site 866536007355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536007356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536007357 dimer interface [polypeptide binding]; other site 866536007358 phosphorylation site [posttranslational modification] 866536007359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007360 ATP binding site [chemical binding]; other site 866536007361 Mg2+ binding site [ion binding]; other site 866536007362 G-X-G motif; other site 866536007363 Cation transport protein; Region: TrkH; cl17365 866536007364 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 866536007365 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 866536007366 TrkA-N domain; Region: TrkA_N; pfam02254 866536007367 TrkA-C domain; Region: TrkA_C; pfam02080 866536007368 TrkA-N domain; Region: TrkA_N; pfam02254 866536007369 TrkA-C domain; Region: TrkA_C; pfam02080 866536007370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007371 binding surface 866536007372 TPR repeat; Region: TPR_11; pfam13414 866536007373 TPR motif; other site 866536007374 RmuC family; Region: RmuC; pfam02646 866536007375 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 866536007376 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 866536007377 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 866536007378 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 866536007379 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 866536007380 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 866536007381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536007382 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 866536007383 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 866536007384 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 866536007385 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 866536007386 PLD-like domain; Region: PLDc_2; pfam13091 866536007387 putative active site [active] 866536007388 catalytic site [active] 866536007389 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 866536007390 oligomeric interface; other site 866536007391 putative active site [active] 866536007392 homodimer interface [polypeptide binding]; other site 866536007393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 866536007394 Putative transposase; Region: Y2_Tnp; pfam04986 866536007395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536007396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536007397 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536007398 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 866536007399 Putative transposase; Region: Y2_Tnp; pfam04986 866536007400 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536007401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536007402 Walker A motif; other site 866536007403 ATP binding site [chemical binding]; other site 866536007404 Walker B motif; other site 866536007405 arginine finger; other site 866536007406 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536007407 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 866536007408 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536007409 Walker A/P-loop; other site 866536007410 ATP binding site [chemical binding]; other site 866536007411 Q-loop/lid; other site 866536007412 ABC transporter signature motif; other site 866536007413 Walker B; other site 866536007414 D-loop; other site 866536007415 H-loop/switch region; other site 866536007416 Integrase core domain; Region: rve; pfam00665 866536007417 Integrase core domain; Region: rve_3; pfam13683 866536007418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536007419 Transposase; Region: HTH_Tnp_1; cl17663 866536007420 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 866536007421 Putative transposase; Region: Y2_Tnp; pfam04986 866536007422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 866536007423 active site 866536007424 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 866536007425 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 866536007426 Uncharacterized conserved protein [Function unknown]; Region: COG1262 866536007427 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 866536007428 Histidine kinase; Region: His_kinase; pfam06580 866536007429 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 866536007430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536007431 active site 866536007432 phosphorylation site [posttranslational modification] 866536007433 intermolecular recognition site; other site 866536007434 dimerization interface [polypeptide binding]; other site 866536007435 LytTr DNA-binding domain; Region: LytTR; smart00850 866536007436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 866536007437 Domain of unknown function DUF20; Region: UPF0118; pfam01594 866536007438 helicase 45; Provisional; Region: PTZ00424 866536007439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866536007440 ATP binding site [chemical binding]; other site 866536007441 Mg++ binding site [ion binding]; other site 866536007442 motif III; other site 866536007443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536007444 nucleotide binding region [chemical binding]; other site 866536007445 ATP-binding site [chemical binding]; other site 866536007446 Predicted membrane protein [Function unknown]; Region: COG4270 866536007447 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 866536007448 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 866536007449 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 866536007450 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 866536007451 active site 866536007452 HIGH motif; other site 866536007453 dimer interface [polypeptide binding]; other site 866536007454 KMSKS motif; other site 866536007455 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 866536007456 RNA binding surface [nucleotide binding]; other site 866536007457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536007458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 866536007459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 866536007460 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 866536007461 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 866536007462 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536007463 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 866536007464 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 866536007465 NADP binding site [chemical binding]; other site 866536007466 dimer interface [polypeptide binding]; other site 866536007467 short chain dehydrogenase; Provisional; Region: PRK07035 866536007468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536007469 NAD(P) binding site [chemical binding]; other site 866536007470 active site 866536007471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536007472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536007473 active site 866536007474 Transposase [DNA replication, recombination, and repair]; Region: COG5421 866536007475 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 866536007476 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 866536007477 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 866536007478 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 866536007479 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536007480 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536007481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007482 ATP binding site [chemical binding]; other site 866536007483 Mg2+ binding site [ion binding]; other site 866536007484 G-X-G motif; other site 866536007485 Response regulator receiver domain; Region: Response_reg; pfam00072 866536007486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536007487 active site 866536007488 phosphorylation site [posttranslational modification] 866536007489 intermolecular recognition site; other site 866536007490 dimerization interface [polypeptide binding]; other site 866536007491 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 866536007492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 866536007493 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 866536007494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 866536007495 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 866536007496 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 866536007497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536007498 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 866536007499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007500 binding surface 866536007501 TPR motif; other site 866536007502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007503 binding surface 866536007504 TPR motif; other site 866536007505 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 866536007506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 866536007507 TPR motif; other site 866536007508 binding surface 866536007509 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 866536007510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007511 binding surface 866536007512 TPR motif; other site 866536007513 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 866536007514 DNA polymerase III, delta subunit; Region: holA; TIGR01128 866536007515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007516 TPR motif; other site 866536007517 TPR repeat; Region: TPR_11; pfam13414 866536007518 binding surface 866536007519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007520 TPR motif; other site 866536007521 binding surface 866536007522 TPR repeat; Region: TPR_11; pfam13414 866536007523 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536007524 Ligand Binding Site [chemical binding]; other site 866536007525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536007526 Ligand Binding Site [chemical binding]; other site 866536007527 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 866536007528 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 866536007529 putative ligand binding site [chemical binding]; other site 866536007530 NAD binding site [chemical binding]; other site 866536007531 dimerization interface [polypeptide binding]; other site 866536007532 catalytic site [active] 866536007533 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536007534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007535 TPR motif; other site 866536007536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007537 binding surface 866536007538 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 866536007539 nudix motif; other site 866536007540 phosphoserine phosphatase SerB; Region: serB; TIGR00338 866536007541 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 866536007542 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 866536007543 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 866536007544 ligand binding site [chemical binding]; other site 866536007545 NAD binding site [chemical binding]; other site 866536007546 tetramer interface [polypeptide binding]; other site 866536007547 catalytic site [active] 866536007548 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 866536007549 L-serine binding site [chemical binding]; other site 866536007550 ACT domain interface; other site 866536007551 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 866536007552 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 866536007553 active site 866536007554 catalytic site [active] 866536007555 substrate binding site [chemical binding]; other site 866536007556 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 866536007557 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 866536007558 GIY-YIG motif/motif A; other site 866536007559 active site 866536007560 catalytic site [active] 866536007561 putative DNA binding site [nucleotide binding]; other site 866536007562 metal binding site [ion binding]; metal-binding site 866536007563 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 866536007564 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536007565 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536007566 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536007567 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536007568 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 866536007569 protein binding site [polypeptide binding]; other site 866536007570 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 866536007571 Domain interface; other site 866536007572 Peptide binding site; other site 866536007573 Active site tetrad [active] 866536007574 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 866536007575 ligand binding site [chemical binding]; other site 866536007576 putative catalytic site [active] 866536007577 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 866536007578 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 866536007579 PYR/PP interface [polypeptide binding]; other site 866536007580 dimer interface [polypeptide binding]; other site 866536007581 TPP binding site [chemical binding]; other site 866536007582 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 866536007583 transketolase; Reviewed; Region: PRK05899 866536007584 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 866536007585 TPP-binding site [chemical binding]; other site 866536007586 dimer interface [polypeptide binding]; other site 866536007587 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 866536007588 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 866536007589 catalytic triad [active] 866536007590 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 866536007591 Peptidase family M23; Region: Peptidase_M23; pfam01551 866536007592 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 866536007593 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 866536007594 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 866536007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866536007596 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 866536007597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536007598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536007599 active site 866536007600 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 866536007601 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 866536007602 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 866536007603 active site 866536007604 HIGH motif; other site 866536007605 dimer interface [polypeptide binding]; other site 866536007606 KMSKS motif; other site 866536007607 Fasciclin domain; Region: Fasciclin; cl02663 866536007608 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 866536007609 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 866536007610 acyl-activating enzyme (AAE) consensus motif; other site 866536007611 putative AMP binding site [chemical binding]; other site 866536007612 putative active site [active] 866536007613 putative CoA binding site [chemical binding]; other site 866536007614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 866536007615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536007616 active site 866536007617 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536007618 M28 Zn-Peptidases; Region: M28_like_4; cd08015 866536007619 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536007620 metal binding site [ion binding]; metal-binding site 866536007621 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 866536007622 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 866536007623 active site 866536007624 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536007625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536007626 ligand binding site [chemical binding]; other site 866536007627 Deoxyhypusine synthase; Region: DS; cl00826 866536007628 deoxyhypusine synthase; Region: dhys; TIGR00321 866536007629 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 866536007630 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 866536007631 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 866536007632 putative active site [active] 866536007633 Zn binding site [ion binding]; other site 866536007634 Divergent AAA domain; Region: AAA_4; pfam04326 866536007635 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 866536007636 Fatty acid desaturase; Region: FA_desaturase; pfam00487 866536007637 Di-iron ligands [ion binding]; other site 866536007638 Penicillinase repressor; Region: Pencillinase_R; pfam03965 866536007639 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 866536007640 Gram-negative bacterial tonB protein; Region: TonB; cl10048 866536007641 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536007642 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 866536007643 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 866536007644 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536007645 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 866536007646 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536007647 Homeodomain-like domain; Region: HTH_23; pfam13384 866536007648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536007649 Integrase core domain; Region: rve; pfam00665 866536007650 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536007651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536007652 Walker A motif; other site 866536007653 ATP binding site [chemical binding]; other site 866536007654 Walker B motif; other site 866536007655 arginine finger; other site 866536007656 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 866536007657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536007658 Walker A/P-loop; other site 866536007659 ATP binding site [chemical binding]; other site 866536007660 Q-loop/lid; other site 866536007661 ABC transporter signature motif; other site 866536007662 Walker B; other site 866536007663 D-loop; other site 866536007664 H-loop/switch region; other site 866536007665 ABC transporter; Region: ABC_tran_2; pfam12848 866536007666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 866536007667 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 866536007668 Na binding site [ion binding]; other site 866536007669 putative glycosylation site [posttranslational modification]; other site 866536007670 putative glycosylation site [posttranslational modification]; other site 866536007671 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 866536007672 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 866536007673 putative RNA binding site [nucleotide binding]; other site 866536007674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536007675 S-adenosylmethionine binding site [chemical binding]; other site 866536007676 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 866536007677 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536007678 Walker A/P-loop; other site 866536007679 ATP binding site [chemical binding]; other site 866536007680 Q-loop/lid; other site 866536007681 ABC transporter signature motif; other site 866536007682 Walker B; other site 866536007683 D-loop; other site 866536007684 H-loop/switch region; other site 866536007685 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 866536007686 DctM-like transporters; Region: DctM; pfam06808 866536007687 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 866536007688 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 866536007689 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 866536007690 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 866536007691 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 866536007692 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 866536007693 active site 866536007694 intersubunit interface [polypeptide binding]; other site 866536007695 catalytic residue [active] 866536007696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 866536007697 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 866536007698 substrate binding site [chemical binding]; other site 866536007699 ATP binding site [chemical binding]; other site 866536007700 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 866536007701 galactarate dehydratase; Region: galactar-dH20; TIGR03248 866536007702 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 866536007703 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 866536007704 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 866536007705 Uncharacterized conserved protein [Function unknown]; Region: COG5470 866536007706 Peptidase family M48; Region: Peptidase_M48; pfam01435 866536007707 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 866536007708 active site 2 [active] 866536007709 active site 1 [active] 866536007710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536007711 active site 866536007712 HIGH motif; other site 866536007713 nucleotide binding site [chemical binding]; other site 866536007714 active site 866536007715 KMSKS motif; other site 866536007716 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 866536007717 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 866536007718 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 866536007719 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 866536007720 TrkA-C domain; Region: TrkA_C; pfam02080 866536007721 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 866536007722 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 866536007723 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866536007724 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 866536007725 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 866536007726 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 866536007727 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 866536007728 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 866536007729 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 866536007730 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 866536007731 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 866536007732 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 866536007733 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 866536007734 DNA-binding site [nucleotide binding]; DNA binding site 866536007735 RNA-binding motif; other site 866536007736 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 866536007737 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 866536007738 active site 866536007739 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 866536007740 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 866536007741 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 866536007742 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 866536007743 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 866536007744 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 866536007745 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 866536007746 PhnA protein; Region: PhnA; pfam03831 866536007747 TPR motif; other site 866536007748 binding surface 866536007749 Tetratricopeptide repeat; Region: TPR_1; pfam00515 866536007750 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 866536007751 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 866536007752 active site 866536007753 NTP binding site [chemical binding]; other site 866536007754 metal binding triad [ion binding]; metal-binding site 866536007755 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 866536007756 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866536007757 Zn2+ binding site [ion binding]; other site 866536007758 Mg2+ binding site [ion binding]; other site 866536007759 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 866536007760 aspartate racemase; Region: asp_race; TIGR00035 866536007761 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 866536007762 CTP synthetase; Validated; Region: pyrG; PRK05380 866536007763 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 866536007764 Catalytic site [active] 866536007765 active site 866536007766 UTP binding site [chemical binding]; other site 866536007767 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 866536007768 active site 866536007769 putative oxyanion hole; other site 866536007770 catalytic triad [active] 866536007771 membrane protein insertase; Provisional; Region: PRK01318 866536007772 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 866536007773 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 866536007774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 866536007775 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 866536007776 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 866536007777 P-loop; other site 866536007778 Magnesium ion binding site [ion binding]; other site 866536007779 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 866536007780 Magnesium ion binding site [ion binding]; other site 866536007781 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 866536007782 ParB-like nuclease domain; Region: ParBc; pfam02195 866536007783 dihydrodipicolinate reductase; Provisional; Region: PRK00048 866536007784 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 866536007785 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 866536007786 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 866536007787 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 866536007788 Catalytic site [active] 866536007789 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 866536007790 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 866536007791 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 866536007792 active site 866536007793 HIGH motif; other site 866536007794 KMSKS motif; other site 866536007795 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 866536007796 tRNA binding surface [nucleotide binding]; other site 866536007797 anticodon binding site; other site 866536007798 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 866536007799 dimer interface [polypeptide binding]; other site 866536007800 putative tRNA-binding site [nucleotide binding]; other site 866536007801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536007802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 866536007803 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 866536007804 Virulence protein [General function prediction only]; Region: COG3943 866536007805 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 866536007806 DEAD-like helicases superfamily; Region: DEXDc; smart00487 866536007807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536007808 ATP binding site [chemical binding]; other site 866536007809 putative Mg++ binding site [ion binding]; other site 866536007810 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 866536007811 Ligase N family; Region: LIGANc; smart00532 866536007812 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 866536007813 nucleotide binding pocket [chemical binding]; other site 866536007814 K-X-D-G motif; other site 866536007815 catalytic site [active] 866536007816 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 866536007817 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 866536007818 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 866536007819 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 866536007820 Dimer interface [polypeptide binding]; other site 866536007821 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 866536007822 dihydrodipicolinate synthase; Region: dapA; TIGR00674 866536007823 dimer interface [polypeptide binding]; other site 866536007824 active site 866536007825 catalytic residue [active] 866536007826 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 866536007827 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 866536007828 generic binding surface II; other site 866536007829 generic binding surface I; other site 866536007830 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 866536007831 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 866536007832 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 866536007833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536007834 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536007835 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536007836 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536007837 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 866536007838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 866536007839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 866536007840 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 866536007841 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 866536007842 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 866536007843 ligand binding site [chemical binding]; other site 866536007844 active site 866536007845 UGI interface [polypeptide binding]; other site 866536007846 catalytic site [active] 866536007847 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 866536007848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536007849 S-adenosylmethionine binding site [chemical binding]; other site 866536007850 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 866536007851 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 866536007852 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 866536007853 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 866536007854 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 866536007855 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 866536007856 Haemolysin-III related; Region: HlyIII; cl03831 866536007857 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 866536007858 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536007859 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536007860 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 866536007861 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 866536007862 dimer interface [polypeptide binding]; other site 866536007863 substrate binding site [chemical binding]; other site 866536007864 ATP binding site [chemical binding]; other site 866536007865 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 866536007866 thiamine phosphate binding site [chemical binding]; other site 866536007867 active site 866536007868 pyrophosphate binding site [ion binding]; other site 866536007869 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 866536007870 substrate binding site [chemical binding]; other site 866536007871 multimerization interface [polypeptide binding]; other site 866536007872 ATP binding site [chemical binding]; other site 866536007873 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 866536007874 putative catalytic site [active] 866536007875 putative metal binding site [ion binding]; other site 866536007876 putative phosphate binding site [ion binding]; other site 866536007877 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536007878 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866536007879 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 866536007880 putative acyl-acceptor binding pocket; other site 866536007881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 866536007882 GAF domain; Region: GAF; pfam01590 866536007883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536007884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536007885 dimer interface [polypeptide binding]; other site 866536007886 phosphorylation site [posttranslational modification] 866536007887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007888 ATP binding site [chemical binding]; other site 866536007889 Mg2+ binding site [ion binding]; other site 866536007890 G-X-G motif; other site 866536007891 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 866536007892 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 866536007893 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 866536007894 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 866536007895 Response regulator receiver domain; Region: Response_reg; pfam00072 866536007896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536007897 active site 866536007898 phosphorylation site [posttranslational modification] 866536007899 intermolecular recognition site; other site 866536007900 dimerization interface [polypeptide binding]; other site 866536007901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 866536007902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 866536007903 Coenzyme A binding pocket [chemical binding]; other site 866536007904 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 866536007905 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 866536007906 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 866536007907 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 866536007908 putative active site [active] 866536007909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536007910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 866536007911 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 866536007912 Fic/DOC family; Region: Fic; pfam02661 866536007913 Integrase core domain; Region: rve; pfam00665 866536007914 Integrase core domain; Region: rve_3; pfam13683 866536007915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 866536007916 Transposase; Region: HTH_Tnp_1; cl17663 866536007917 Homeodomain-like domain; Region: HTH_23; pfam13384 866536007918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536007919 Integrase core domain; Region: rve; pfam00665 866536007920 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536007921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536007922 Walker A motif; other site 866536007923 ATP binding site [chemical binding]; other site 866536007924 Walker B motif; other site 866536007925 arginine finger; other site 866536007926 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536007927 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536007928 NlpE N-terminal domain; Region: NlpE; pfam04170 866536007929 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 866536007930 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536007931 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536007932 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 866536007933 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536007934 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 866536007935 protein binding site [polypeptide binding]; other site 866536007936 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 866536007937 Domain interface; other site 866536007938 Peptide binding site; other site 866536007939 Active site tetrad [active] 866536007940 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866536007941 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 866536007942 active site 866536007943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 866536007944 acyl-CoA oxidase; Region: PLN02312 866536007945 active site 866536007946 GldH lipoprotein; Region: GldH_lipo; cl11905 866536007947 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 866536007948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536007949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007951 binding surface 866536007952 TPR motif; other site 866536007953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 866536007956 binding surface 866536007957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007958 TPR motif; other site 866536007959 Tetratricopeptide repeat; Region: TPR_12; pfam13424 866536007960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536007961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536007962 ATP binding site [chemical binding]; other site 866536007963 Mg2+ binding site [ion binding]; other site 866536007964 G-X-G motif; other site 866536007965 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 866536007966 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 866536007967 phosphodiesterase YaeI; Provisional; Region: PRK11340 866536007968 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 866536007969 putative active site [active] 866536007970 putative metal binding site [ion binding]; other site 866536007971 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536007972 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 866536007973 protein binding site [polypeptide binding]; other site 866536007974 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 866536007975 Catalytic dyad [active] 866536007976 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 866536007977 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 866536007978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536007979 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 866536007980 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 866536007981 inhibitor-cofactor binding pocket; inhibition site 866536007982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536007983 catalytic residue [active] 866536007984 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 866536007985 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 866536007986 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 866536007987 Transposase IS200 like; Region: Y1_Tnp; cl00848 866536007988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 866536007989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 866536007990 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 866536007991 active site 866536007992 von Willebrand factor type A domain; Region: VWA_2; pfam13519 866536007993 metal ion-dependent adhesion site (MIDAS); other site 866536007994 acetyl-CoA C-acetyltransferase; Region: PLN02644 866536007995 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 866536007996 dimer interface [polypeptide binding]; other site 866536007997 active site 866536007998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536007999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536008000 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 866536008001 ATP binding site [chemical binding]; other site 866536008002 active site 866536008003 substrate binding site [chemical binding]; other site 866536008004 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 866536008005 anti sigma factor interaction site; other site 866536008006 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 866536008007 regulatory phosphorylation site [posttranslational modification]; other site 866536008008 ribonuclease Z; Region: RNase_Z; TIGR02651 866536008009 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 866536008010 short chain dehydrogenase; Provisional; Region: PRK07326 866536008011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536008012 NAD(P) binding site [chemical binding]; other site 866536008013 active site 866536008014 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 866536008015 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 866536008016 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 866536008017 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 866536008018 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 866536008019 putative active site [active] 866536008020 metal binding site [ion binding]; metal-binding site 866536008021 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 866536008022 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 866536008023 catalytic residues [active] 866536008024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536008025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536008026 ligand binding site [chemical binding]; other site 866536008027 flexible hinge region; other site 866536008028 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 866536008029 HPP family; Region: HPP; pfam04982 866536008030 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 866536008031 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 866536008032 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 866536008033 heme-binding site [chemical binding]; other site 866536008034 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 866536008035 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 866536008036 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 866536008037 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 866536008038 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 866536008039 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 866536008040 Low-spin heme binding site [chemical binding]; other site 866536008041 D-pathway; other site 866536008042 Putative water exit pathway; other site 866536008043 Binuclear center (active site) [active] 866536008044 K-pathway; other site 866536008045 Putative proton exit pathway; other site 866536008046 Rrf2 family protein; Region: rrf2_super; TIGR00738 866536008047 Transcriptional regulator; Region: Rrf2; pfam02082 866536008048 Protoglobin; Region: Protoglobin; pfam11563 866536008049 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 866536008050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 866536008051 MarR family; Region: MarR_2; pfam12802 866536008052 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 866536008053 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 866536008054 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 866536008055 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 866536008056 active site 866536008057 Sulfatase; Region: Sulfatase; cl17466 866536008058 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 866536008059 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 866536008060 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 866536008061 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 866536008062 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 866536008063 active site 866536008064 catalytic triad [active] 866536008065 oxyanion hole [active] 866536008066 Domain of unknown function (DUF303); Region: DUF303; pfam03629 866536008067 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 866536008068 active site 866536008069 catalytic triad [active] 866536008070 oxyanion hole [active] 866536008071 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 866536008072 dimerization interface [polypeptide binding]; other site 866536008073 putative active cleft [active] 866536008074 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 866536008075 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 866536008076 ligand binding site; other site 866536008077 tetramer interface; other site 866536008078 Helix-turn-helix domain; Region: HTH_18; pfam12833 866536008079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536008080 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 866536008081 catalytic site [active] 866536008082 BNR repeat-like domain; Region: BNR_2; pfam13088 866536008083 Asp-box motif; other site 866536008084 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 866536008085 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 866536008086 Na binding site [ion binding]; other site 866536008087 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 866536008088 Class I aldolases; Region: Aldolase_Class_I; cl17187 866536008089 catalytic residue [active] 866536008090 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536008091 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536008092 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536008093 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536008094 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536008095 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536008096 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536008097 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536008098 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 866536008099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536008100 dimer interface [polypeptide binding]; other site 866536008101 phosphorylation site [posttranslational modification] 866536008102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536008103 ATP binding site [chemical binding]; other site 866536008104 Mg2+ binding site [ion binding]; other site 866536008105 G-X-G motif; other site 866536008106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008107 active site 866536008108 phosphorylation site [posttranslational modification] 866536008109 intermolecular recognition site; other site 866536008110 dimerization interface [polypeptide binding]; other site 866536008111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536008112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536008113 Creatinine amidohydrolase; Region: Creatininase; pfam02633 866536008114 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 866536008115 active site 866536008116 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 866536008117 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 866536008118 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 866536008119 nucleotide binding site [chemical binding]; other site 866536008120 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536008121 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536008122 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536008123 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 866536008124 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536008125 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536008126 SusD family; Region: SusD; pfam07980 866536008127 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 866536008128 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 866536008129 sugar binding site [chemical binding]; other site 866536008130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536008131 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536008132 Amidohydrolase; Region: Amidohydro_2; pfam04909 866536008133 active site 866536008134 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 866536008135 intersubunit interface [polypeptide binding]; other site 866536008136 active site 866536008137 zinc binding site [ion binding]; other site 866536008138 Na+ binding site [ion binding]; other site 866536008139 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 866536008140 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 866536008141 substrate binding site [chemical binding]; other site 866536008142 ATP binding site [chemical binding]; other site 866536008143 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 866536008144 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 866536008145 putative substrate binding site [chemical binding]; other site 866536008146 putative ATP binding site [chemical binding]; other site 866536008147 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 866536008148 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 866536008149 dimer interface [polypeptide binding]; other site 866536008150 active site 866536008151 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 866536008152 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 866536008153 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 866536008154 Na binding site [ion binding]; other site 866536008155 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 866536008156 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 866536008157 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 866536008158 active site 866536008159 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 866536008160 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 866536008161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536008162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536008163 Uncharacterized conserved protein [Function unknown]; Region: COG1262 866536008164 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 866536008165 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 866536008166 Sulfatase; Region: Sulfatase; pfam00884 866536008167 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 866536008168 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 866536008169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 866536008170 ATP binding site [chemical binding]; other site 866536008171 putative Mg++ binding site [ion binding]; other site 866536008172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536008173 nucleotide binding region [chemical binding]; other site 866536008174 ATP-binding site [chemical binding]; other site 866536008175 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 866536008176 Domain of unknown function DUF302; Region: DUF302; cl01364 866536008177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536008178 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536008179 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536008180 fumarylacetoacetase; Region: PLN02856 866536008181 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 866536008182 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 866536008183 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 866536008184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 866536008185 homodimer interface [polypeptide binding]; other site 866536008186 metal binding site [ion binding]; metal-binding site 866536008187 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 866536008188 putative active site [active] 866536008189 dimerization interface [polypeptide binding]; other site 866536008190 putative tRNAtyr binding site [nucleotide binding]; other site 866536008191 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 866536008192 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 866536008193 NAD binding site [chemical binding]; other site 866536008194 active site 866536008195 Uncharacterized conserved protein [Function unknown]; Region: COG3339 866536008196 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 866536008197 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 866536008198 Int/Topo IB signature motif; other site 866536008199 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 866536008200 active site 866536008201 catalytic triad [active] 866536008202 dimer interface [polypeptide binding]; other site 866536008203 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 866536008204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536008205 Walker A motif; other site 866536008206 ATP binding site [chemical binding]; other site 866536008207 Walker B motif; other site 866536008208 arginine finger; other site 866536008209 Homeodomain-like domain; Region: HTH_23; pfam13384 866536008210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 866536008211 Integrase core domain; Region: rve; pfam00665 866536008212 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 866536008213 putative substrate binding site [chemical binding]; other site 866536008214 active site 866536008215 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 866536008216 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 866536008217 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 866536008218 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 866536008219 active site 866536008220 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 866536008221 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 866536008222 active site 866536008223 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536008224 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536008225 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536008226 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536008227 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536008228 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536008229 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 866536008230 Two component regulator propeller; Region: Reg_prop; pfam07494 866536008231 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 866536008232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536008233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536008234 dimer interface [polypeptide binding]; other site 866536008235 phosphorylation site [posttranslational modification] 866536008236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536008237 ATP binding site [chemical binding]; other site 866536008238 Mg2+ binding site [ion binding]; other site 866536008239 G-X-G motif; other site 866536008240 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536008241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008242 active site 866536008243 phosphorylation site [posttranslational modification] 866536008244 intermolecular recognition site; other site 866536008245 dimerization interface [polypeptide binding]; other site 866536008246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 866536008247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 866536008248 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 866536008249 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 866536008250 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 866536008251 Int/Topo IB signature motif; other site 866536008252 Helix-turn-helix domain; Region: HTH_17; pfam12728 866536008253 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 866536008254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 866536008255 AAA domain; Region: AAA_33; pfam13671 866536008256 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 866536008257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536008258 Walker A/P-loop; other site 866536008259 ATP binding site [chemical binding]; other site 866536008260 Q-loop/lid; other site 866536008261 ABC transporter signature motif; other site 866536008262 Walker B; other site 866536008263 D-loop; other site 866536008264 H-loop/switch region; other site 866536008265 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 866536008266 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 866536008267 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 866536008268 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 866536008269 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 866536008270 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 866536008271 active site 866536008272 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536008273 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 866536008274 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 866536008275 Peptidase family M28; Region: Peptidase_M28; pfam04389 866536008276 metal binding site [ion binding]; metal-binding site 866536008277 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 866536008278 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 866536008279 putative acyl-acceptor binding pocket; other site 866536008280 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 866536008281 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 866536008282 active site 866536008283 nucleophile elbow; other site 866536008284 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 866536008285 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 866536008286 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 866536008287 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 866536008288 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 866536008289 NAD binding site [chemical binding]; other site 866536008290 homodimer interface [polypeptide binding]; other site 866536008291 active site 866536008292 substrate binding site [chemical binding]; other site 866536008293 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 866536008294 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 866536008295 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 866536008296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 866536008297 DNA binding residues [nucleotide binding] 866536008298 DNA protecting protein DprA; Region: dprA; TIGR00732 866536008299 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 866536008300 signal recognition particle protein; Provisional; Region: PRK10867 866536008301 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 866536008302 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 866536008303 P loop; other site 866536008304 GTP binding site [chemical binding]; other site 866536008305 Signal peptide binding domain; Region: SRP_SPB; pfam02978 866536008306 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 866536008307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536008308 S-adenosylmethionine binding site [chemical binding]; other site 866536008309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 866536008310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536008311 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 866536008312 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 866536008313 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536008314 Ligand Binding Site [chemical binding]; other site 866536008315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536008316 Ligand Binding Site [chemical binding]; other site 866536008317 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 866536008318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536008319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536008320 DNA binding residues [nucleotide binding] 866536008321 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 866536008322 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 866536008323 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 866536008324 active site 866536008325 dimer interfaces [polypeptide binding]; other site 866536008326 catalytic residues [active] 866536008327 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363 866536008328 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 866536008329 active site 866536008330 ADP/pyrophosphate binding site [chemical binding]; other site 866536008331 dimerization interface [polypeptide binding]; other site 866536008332 allosteric effector site; other site 866536008333 fructose-1,6-bisphosphate binding site; other site 866536008334 trehalose synthase; Region: treS_nterm; TIGR02456 866536008335 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 866536008336 Ca binding site [ion binding]; other site 866536008337 active site 866536008338 catalytic site [active] 866536008339 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 866536008340 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 866536008341 active site 866536008342 intersubunit interface [polypeptide binding]; other site 866536008343 zinc binding site [ion binding]; other site 866536008344 Na+ binding site [ion binding]; other site 866536008345 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 866536008346 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 866536008347 active site 866536008348 catalytic site [active] 866536008349 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536008350 SusE outer membrane protein; Region: SusE; pfam14292 866536008351 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 866536008352 starch binding site [chemical binding]; other site 866536008353 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 866536008354 starch binding site [chemical binding]; other site 866536008355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 866536008356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 866536008357 DNA binding site [nucleotide binding] 866536008358 domain linker motif; other site 866536008359 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 866536008360 dimerization interface [polypeptide binding]; other site 866536008361 ligand binding site [chemical binding]; other site 866536008362 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 866536008363 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 866536008364 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 866536008365 trimer interface [polypeptide binding]; other site 866536008366 active site 866536008367 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 866536008368 catalytic site [active] 866536008369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536008370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536008371 putative substrate translocation pore; other site 866536008372 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 866536008373 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 866536008374 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 866536008375 active site 866536008376 catalytic residues [active] 866536008377 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 866536008378 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 866536008379 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 866536008380 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 866536008381 dimerization interface [polypeptide binding]; other site 866536008382 active site 866536008383 DNA primase; Validated; Region: dnaG; PRK05667 866536008384 CHC2 zinc finger; Region: zf-CHC2; pfam01807 866536008385 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 866536008386 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 866536008387 active site 866536008388 metal binding site [ion binding]; metal-binding site 866536008389 interdomain interaction site; other site 866536008390 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 866536008391 antiporter inner membrane protein; Provisional; Region: PRK11670 866536008392 Domain of unknown function DUF59; Region: DUF59; pfam01883 866536008393 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 866536008394 Walker A motif; other site 866536008395 NifU-like domain; Region: NifU; pfam01106 866536008396 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 866536008397 active site 866536008398 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536008399 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 866536008400 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 866536008401 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 866536008402 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 866536008403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536008404 active site residue [active] 866536008405 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 866536008406 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 866536008407 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 866536008408 Peptidase family M50; Region: Peptidase_M50; pfam02163 866536008409 active site 866536008410 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 866536008411 putative substrate binding region [chemical binding]; other site 866536008412 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 866536008413 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 866536008414 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 866536008415 Chain length determinant protein; Region: Wzz; cl15801 866536008416 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 866536008417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 866536008418 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 866536008419 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 866536008420 Ligand binding site; other site 866536008421 oligomer interface; other site 866536008422 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 866536008423 nucleotide binding site/active site [active] 866536008424 HIT family signature motif; other site 866536008425 catalytic residue [active] 866536008426 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 866536008427 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 866536008428 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 866536008429 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536008430 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 866536008431 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 866536008432 putative ligand binding site [chemical binding]; other site 866536008433 putative NAD binding site [chemical binding]; other site 866536008434 catalytic site [active] 866536008435 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 866536008436 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 866536008437 dimer interface [polypeptide binding]; other site 866536008438 ssDNA binding site [nucleotide binding]; other site 866536008439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 866536008440 6-phosphofructokinase; Provisional; Region: PRK03202 866536008441 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 866536008442 active site 866536008443 ADP/pyrophosphate binding site [chemical binding]; other site 866536008444 dimerization interface [polypeptide binding]; other site 866536008445 allosteric effector site; other site 866536008446 fructose-1,6-bisphosphate binding site; other site 866536008447 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 866536008448 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 866536008449 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536008450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008451 active site 866536008452 phosphorylation site [posttranslational modification] 866536008453 intermolecular recognition site; other site 866536008454 dimerization interface [polypeptide binding]; other site 866536008455 Response regulator receiver domain; Region: Response_reg; pfam00072 866536008456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008457 active site 866536008458 phosphorylation site [posttranslational modification] 866536008459 intermolecular recognition site; other site 866536008460 dimerization interface [polypeptide binding]; other site 866536008461 putative hydrolase; Provisional; Region: PRK02113 866536008462 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 866536008463 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 866536008464 Domain of unknown function (DUF814); Region: DUF814; pfam05670 866536008465 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 866536008466 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 866536008467 domain interfaces; other site 866536008468 active site 866536008469 acyl carrier protein; Provisional; Region: acpP; PRK00982 866536008470 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 866536008471 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 866536008472 dimer interface [polypeptide binding]; other site 866536008473 active site 866536008474 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 866536008475 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 866536008476 dimerization interface [polypeptide binding]; other site 866536008477 active site 866536008478 metal binding site [ion binding]; metal-binding site 866536008479 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 866536008480 dsRNA binding site [nucleotide binding]; other site 866536008481 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 866536008482 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 866536008483 multimer interface [polypeptide binding]; other site 866536008484 active site 866536008485 catalytic triad [active] 866536008486 protein interface 1 [polypeptide binding]; other site 866536008487 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 866536008488 homodimer interface [polypeptide binding]; other site 866536008489 NAD binding pocket [chemical binding]; other site 866536008490 ATP binding pocket [chemical binding]; other site 866536008491 Mg binding site [ion binding]; other site 866536008492 active-site loop [active] 866536008493 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 866536008494 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 866536008495 Haemolytic domain; Region: Haemolytic; pfam01809 866536008496 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536008497 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 866536008498 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 866536008499 active site 866536008500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536008501 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 866536008502 active site residue [active] 866536008503 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 866536008504 AAA domain; Region: AAA_14; pfam13173 866536008505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 866536008506 DNA-binding site [nucleotide binding]; DNA binding site 866536008507 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 866536008508 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 866536008509 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 866536008510 metal binding site [ion binding]; metal-binding site 866536008511 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 866536008512 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 866536008513 substrate binding site [chemical binding]; other site 866536008514 glutamase interaction surface [polypeptide binding]; other site 866536008515 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 866536008516 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 866536008517 catalytic residues [active] 866536008518 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 866536008519 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 866536008520 putative active site [active] 866536008521 oxyanion strand; other site 866536008522 catalytic triad [active] 866536008523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 866536008524 extended (e) SDRs; Region: SDR_e; cd08946 866536008525 NAD(P) binding site [chemical binding]; other site 866536008526 active site 866536008527 substrate binding site [chemical binding]; other site 866536008528 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 866536008529 cofactor binding site; other site 866536008530 metal binding site [ion binding]; metal-binding site 866536008531 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 866536008532 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 866536008533 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 866536008534 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 866536008535 substrate binding site [chemical binding]; other site 866536008536 active site 866536008537 catalytic residues [active] 866536008538 heterodimer interface [polypeptide binding]; other site 866536008539 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 866536008540 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 866536008541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536008542 catalytic residue [active] 866536008543 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 866536008544 active site 866536008545 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 866536008546 active site 866536008547 ribulose/triose binding site [chemical binding]; other site 866536008548 phosphate binding site [ion binding]; other site 866536008549 substrate (anthranilate) binding pocket [chemical binding]; other site 866536008550 product (indole) binding pocket [chemical binding]; other site 866536008551 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 866536008552 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 866536008553 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 866536008554 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 866536008555 Glutamine amidotransferase class-I; Region: GATase; pfam00117 866536008556 glutamine binding [chemical binding]; other site 866536008557 catalytic triad [active] 866536008558 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 866536008559 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 866536008560 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 866536008561 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 866536008562 putative metal binding site [ion binding]; other site 866536008563 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 866536008564 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 866536008565 Protein of unknown function (DUF819); Region: DUF819; cl02317 866536008566 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 866536008567 putative active site [active] 866536008568 putative CoA binding site [chemical binding]; other site 866536008569 nudix motif; other site 866536008570 metal binding site [ion binding]; metal-binding site 866536008571 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536008572 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 866536008573 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 866536008574 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 866536008575 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 866536008576 Surface antigen; Region: Bac_surface_Ag; pfam01103 866536008577 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 866536008578 Family of unknown function (DUF490); Region: DUF490; pfam04357 866536008579 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 866536008580 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 866536008581 TRAM domain; Region: TRAM; pfam01938 866536008582 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 866536008583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536008584 Walker A motif; other site 866536008585 ATP binding site [chemical binding]; other site 866536008586 Walker B motif; other site 866536008587 arginine finger; other site 866536008588 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 866536008589 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 866536008590 oligomerisation interface [polypeptide binding]; other site 866536008591 mobile loop; other site 866536008592 roof hairpin; other site 866536008593 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 866536008594 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 866536008595 ring oligomerisation interface [polypeptide binding]; other site 866536008596 ATP/Mg binding site [chemical binding]; other site 866536008597 stacking interactions; other site 866536008598 hinge regions; other site 866536008599 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536008600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008601 active site 866536008602 phosphorylation site [posttranslational modification] 866536008603 intermolecular recognition site; other site 866536008604 dimerization interface [polypeptide binding]; other site 866536008605 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 866536008606 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 866536008607 oligomer interface [polypeptide binding]; other site 866536008608 metal binding site [ion binding]; metal-binding site 866536008609 metal binding site [ion binding]; metal-binding site 866536008610 Cl binding site [ion binding]; other site 866536008611 aspartate ring; other site 866536008612 basic sphincter; other site 866536008613 putative hydrophobic gate; other site 866536008614 periplasmic entrance; other site 866536008615 gamma-glutamyl kinase; Provisional; Region: PRK05429 866536008616 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 866536008617 nucleotide binding site [chemical binding]; other site 866536008618 homotetrameric interface [polypeptide binding]; other site 866536008619 putative phosphate binding site [ion binding]; other site 866536008620 putative allosteric binding site; other site 866536008621 PUA domain; Region: PUA; pfam01472 866536008622 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 866536008623 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 866536008624 putative catalytic cysteine [active] 866536008625 Protein of unknown function (DUF983); Region: DUF983; cl02211 866536008626 methionine sulfoxide reductase A; Provisional; Region: PRK14054 866536008627 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 866536008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 866536008629 Response regulator receiver domain; Region: Response_reg; pfam00072 866536008630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008631 active site 866536008632 phosphorylation site [posttranslational modification] 866536008633 intermolecular recognition site; other site 866536008634 dimerization interface [polypeptide binding]; other site 866536008635 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 866536008636 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 866536008637 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 866536008638 DXD motif; other site 866536008639 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 866536008640 HEAT repeats; Region: HEAT_2; pfam13646 866536008641 Response regulator receiver domain; Region: Response_reg; pfam00072 866536008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008643 active site 866536008644 phosphorylation site [posttranslational modification] 866536008645 intermolecular recognition site; other site 866536008646 dimerization interface [polypeptide binding]; other site 866536008647 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 866536008648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536008649 active site 866536008650 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 866536008651 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 866536008652 active site 866536008653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536008654 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 866536008655 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536008656 active site 866536008657 Bacterial SH3 domain; Region: SH3_3; cl17532 866536008658 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 866536008659 NlpC/P60 family; Region: NLPC_P60; pfam00877 866536008660 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 866536008661 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 866536008662 active site 866536008663 DNA polymerase IV; Validated; Region: PRK02406 866536008664 DNA binding site [nucleotide binding] 866536008665 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 866536008666 chorismate binding enzyme; Region: Chorismate_bind; cl10555 866536008667 YceI-like domain; Region: YceI; pfam04264 866536008668 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 866536008669 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 866536008670 trimer interface [polypeptide binding]; other site 866536008671 putative metal binding site [ion binding]; other site 866536008672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 866536008673 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536008674 carboxylate-amine ligase; Provisional; Region: PRK13515 866536008675 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 866536008676 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 866536008677 conserved cys residue [active] 866536008678 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 866536008679 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 866536008680 ligand binding site [chemical binding]; other site 866536008681 homodimer interface [polypeptide binding]; other site 866536008682 NAD(P) binding site [chemical binding]; other site 866536008683 trimer interface B [polypeptide binding]; other site 866536008684 trimer interface A [polypeptide binding]; other site 866536008685 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 866536008686 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 866536008687 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 866536008688 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 866536008689 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 866536008690 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 866536008691 putative catalytic site [active] 866536008692 putative metal binding site [ion binding]; other site 866536008693 putative phosphate binding site [ion binding]; other site 866536008694 GH3 auxin-responsive promoter; Region: GH3; pfam03321 866536008695 putative transporter; Provisional; Region: PRK10484 866536008696 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 866536008697 Na binding site [ion binding]; other site 866536008698 substrate binding site [chemical binding]; other site 866536008699 PAS domain; Region: PAS; smart00091 866536008700 PAS fold; Region: PAS_4; pfam08448 866536008701 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 866536008702 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 866536008703 Potassium binding sites [ion binding]; other site 866536008704 Cesium cation binding sites [ion binding]; other site 866536008705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 866536008706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 866536008707 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 866536008708 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 866536008709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536008710 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 866536008711 active site 866536008712 Zn binding site [ion binding]; other site 866536008713 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 866536008714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 866536008715 putative DNA binding site [nucleotide binding]; other site 866536008716 putative Zn2+ binding site [ion binding]; other site 866536008717 AsnC family; Region: AsnC_trans_reg; pfam01037 866536008718 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 866536008719 putative ABC transporter; Region: ycf24; CHL00085 866536008720 FeS assembly ATPase SufC; Region: sufC; TIGR01978 866536008721 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 866536008722 Walker A/P-loop; other site 866536008723 ATP binding site [chemical binding]; other site 866536008724 Q-loop/lid; other site 866536008725 ABC transporter signature motif; other site 866536008726 Walker B; other site 866536008727 D-loop; other site 866536008728 H-loop/switch region; other site 866536008729 FeS assembly protein SufD; Region: sufD; TIGR01981 866536008730 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 866536008731 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 866536008732 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 866536008733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 866536008734 catalytic residue [active] 866536008735 Fe-S metabolism associated domain; Region: SufE; cl00951 866536008736 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 866536008737 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 866536008738 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 866536008739 dimer interface [polypeptide binding]; other site 866536008740 Citrate synthase; Region: Citrate_synt; pfam00285 866536008741 active site 866536008742 citrylCoA binding site [chemical binding]; other site 866536008743 NADH binding [chemical binding]; other site 866536008744 cationic pore residues; other site 866536008745 oxalacetate/citrate binding site [chemical binding]; other site 866536008746 coenzyme A binding site [chemical binding]; other site 866536008747 catalytic triad [active] 866536008748 Acyl CoA binding protein; Region: ACBP; pfam00887 866536008749 acyl-CoA binding pocket [chemical binding]; other site 866536008750 CoA binding site [chemical binding]; other site 866536008751 helicase 45; Provisional; Region: PTZ00424 866536008752 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866536008753 ATP binding site [chemical binding]; other site 866536008754 Mg++ binding site [ion binding]; other site 866536008755 motif III; other site 866536008756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536008757 nucleotide binding region [chemical binding]; other site 866536008758 ATP-binding site [chemical binding]; other site 866536008759 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 866536008760 RNA binding site [nucleotide binding]; other site 866536008761 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 866536008762 RNA methyltransferase, RsmE family; Region: TIGR00046 866536008763 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 866536008764 Putative esterase; Region: Esterase; pfam00756 866536008765 multifunctional aminopeptidase A; Provisional; Region: PRK00913 866536008766 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 866536008767 interface (dimer of trimers) [polypeptide binding]; other site 866536008768 Substrate-binding/catalytic site; other site 866536008769 Zn-binding sites [ion binding]; other site 866536008770 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 866536008771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 866536008772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536008773 non-specific DNA binding site [nucleotide binding]; other site 866536008774 salt bridge; other site 866536008775 sequence-specific DNA binding site [nucleotide binding]; other site 866536008776 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 866536008777 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 866536008778 probable DNA repair protein; Region: TIGR03623 866536008779 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 866536008780 Part of AAA domain; Region: AAA_19; pfam13245 866536008781 putative recombination protein RecB; Provisional; Region: PRK13909 866536008782 Family description; Region: UvrD_C_2; pfam13538 866536008783 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 866536008784 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 866536008785 FAD binding domain; Region: FAD_binding_4; pfam01565 866536008786 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 866536008787 Uncharacterized conserved protein [Function unknown]; Region: COG1434 866536008788 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 866536008789 putative active site [active] 866536008790 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 866536008791 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 866536008792 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 866536008793 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536008794 N-terminal plug; other site 866536008795 ligand-binding site [chemical binding]; other site 866536008796 Response regulator receiver domain; Region: Response_reg; pfam00072 866536008797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008798 active site 866536008799 phosphorylation site [posttranslational modification] 866536008800 intermolecular recognition site; other site 866536008801 dimerization interface [polypeptide binding]; other site 866536008802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536008803 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 866536008804 Walker A motif; other site 866536008805 ATP binding site [chemical binding]; other site 866536008806 Walker B motif; other site 866536008807 arginine finger; other site 866536008808 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 866536008809 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536008810 acetolactate synthase; Reviewed; Region: PRK08322 866536008811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 866536008812 PYR/PP interface [polypeptide binding]; other site 866536008813 dimer interface [polypeptide binding]; other site 866536008814 TPP binding site [chemical binding]; other site 866536008815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 866536008816 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 866536008817 TPP-binding site [chemical binding]; other site 866536008818 dimer interface [polypeptide binding]; other site 866536008819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 866536008820 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 866536008821 NAD(P) binding site [chemical binding]; other site 866536008822 catalytic residues [active] 866536008823 Predicted acetyltransferase [General function prediction only]; Region: COG2388 866536008824 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 866536008825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536008826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 866536008827 putative substrate translocation pore; other site 866536008828 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 866536008829 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 866536008830 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 866536008831 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 866536008832 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 866536008833 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 866536008834 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 866536008835 ATP binding site [chemical binding]; other site 866536008836 Mg++ binding site [ion binding]; other site 866536008837 motif III; other site 866536008838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 866536008839 nucleotide binding region [chemical binding]; other site 866536008840 ATP-binding site [chemical binding]; other site 866536008841 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 866536008842 high affinity sulphate transporter 1; Region: sulP; TIGR00815 866536008843 Sulfate transporter family; Region: Sulfate_transp; pfam00916 866536008844 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 866536008845 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 866536008846 active site clefts [active] 866536008847 zinc binding site [ion binding]; other site 866536008848 dimer interface [polypeptide binding]; other site 866536008849 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 866536008850 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 866536008851 ligand binding site [chemical binding]; other site 866536008852 flexible hinge region; other site 866536008853 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 866536008854 non-specific DNA interactions [nucleotide binding]; other site 866536008855 DNA binding site [nucleotide binding] 866536008856 sequence specific DNA binding site [nucleotide binding]; other site 866536008857 putative cAMP binding site [chemical binding]; other site 866536008858 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 866536008859 classical (c) SDRs; Region: SDR_c; cd05233 866536008860 NAD(P) binding site [chemical binding]; other site 866536008861 active site 866536008862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536008863 Ligand Binding Site [chemical binding]; other site 866536008864 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 866536008865 Ligand Binding Site [chemical binding]; other site 866536008866 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 866536008867 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 866536008868 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 866536008869 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 866536008870 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 866536008871 active site 866536008872 catalytic residues [active] 866536008873 metal binding site [ion binding]; metal-binding site 866536008874 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 866536008875 FAD binding site [chemical binding]; other site 866536008876 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 866536008877 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 866536008878 substrate binding pocket [chemical binding]; other site 866536008879 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 866536008880 B12 binding site [chemical binding]; other site 866536008881 cobalt ligand [ion binding]; other site 866536008882 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 866536008883 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 866536008884 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 866536008885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536008886 PAS fold; Region: PAS_4; pfam08448 866536008887 putative active site [active] 866536008888 heme pocket [chemical binding]; other site 866536008889 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 866536008890 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 866536008891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536008892 PAS domain; Region: PAS_9; pfam13426 866536008893 putative active site [active] 866536008894 heme pocket [chemical binding]; other site 866536008895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536008896 PAS fold; Region: PAS_3; pfam08447 866536008897 putative active site [active] 866536008898 heme pocket [chemical binding]; other site 866536008899 PAS fold; Region: PAS_4; pfam08448 866536008900 PAS domain S-box; Region: sensory_box; TIGR00229 866536008901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536008902 putative active site [active] 866536008903 heme pocket [chemical binding]; other site 866536008904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536008905 dimer interface [polypeptide binding]; other site 866536008906 phosphorylation site [posttranslational modification] 866536008907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536008908 ATP binding site [chemical binding]; other site 866536008909 Mg2+ binding site [ion binding]; other site 866536008910 G-X-G motif; other site 866536008911 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 866536008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008913 active site 866536008914 phosphorylation site [posttranslational modification] 866536008915 intermolecular recognition site; other site 866536008916 dimerization interface [polypeptide binding]; other site 866536008917 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 866536008918 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 866536008919 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536008920 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 866536008921 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536008922 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 866536008923 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 866536008924 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 866536008925 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 866536008926 HlyD family secretion protein; Region: HlyD_3; pfam13437 866536008927 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 866536008928 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 866536008929 putative active site [active] 866536008930 substrate binding site [chemical binding]; other site 866536008931 putative cosubstrate binding site; other site 866536008932 catalytic site [active] 866536008933 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 866536008934 substrate binding site [chemical binding]; other site 866536008935 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 866536008936 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 866536008937 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 866536008938 folate binding site [chemical binding]; other site 866536008939 NADP+ binding site [chemical binding]; other site 866536008940 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 866536008941 short chain dehydrogenase; Provisional; Region: PRK06181 866536008942 NADP binding site [chemical binding]; other site 866536008943 homodimer interface [polypeptide binding]; other site 866536008944 substrate binding site [chemical binding]; other site 866536008945 active site 866536008946 competence damage-inducible protein A; Provisional; Region: PRK00549 866536008947 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 866536008948 putative MPT binding site; other site 866536008949 Competence-damaged protein; Region: CinA; pfam02464 866536008950 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 866536008951 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 866536008952 E3 interaction surface; other site 866536008953 lipoyl attachment site [posttranslational modification]; other site 866536008954 e3 binding domain; Region: E3_binding; pfam02817 866536008955 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 866536008956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 866536008957 PAS fold; Region: PAS_3; pfam08447 866536008958 putative active site [active] 866536008959 heme pocket [chemical binding]; other site 866536008960 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 866536008961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536008962 dimer interface [polypeptide binding]; other site 866536008963 phosphorylation site [posttranslational modification] 866536008964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536008965 ATP binding site [chemical binding]; other site 866536008966 Mg2+ binding site [ion binding]; other site 866536008967 G-X-G motif; other site 866536008968 Response regulator receiver domain; Region: Response_reg; pfam00072 866536008969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536008970 active site 866536008971 phosphorylation site [posttranslational modification] 866536008972 intermolecular recognition site; other site 866536008973 dimerization interface [polypeptide binding]; other site 866536008974 Cache domain; Region: Cache_1; pfam02743 866536008975 OsmC-like protein; Region: OsmC; pfam02566 866536008976 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 866536008977 B12 binding site [chemical binding]; other site 866536008978 cobalt ligand [ion binding]; other site 866536008979 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 866536008980 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 866536008981 Walker A; other site 866536008982 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 866536008983 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 866536008984 active site 866536008985 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 866536008986 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 866536008987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536008988 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 866536008989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 866536008990 motif II; other site 866536008991 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 866536008992 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 866536008993 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 866536008994 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 866536008995 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536008996 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536008997 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 866536008998 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536008999 gliding motility-associated protein GldC; Region: GldC; TIGR03515 866536009000 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 866536009001 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 866536009002 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 866536009003 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 866536009004 active site 866536009005 Riboflavin kinase; Region: Flavokinase; pfam01687 866536009006 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 866536009007 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 866536009008 RNA binding site [nucleotide binding]; other site 866536009009 active site 866536009010 Bacitracin resistance protein BacA; Region: BacA; pfam02673 866536009011 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 866536009012 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 866536009013 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 866536009014 FtsX-like permease family; Region: FtsX; pfam02687 866536009015 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866536009016 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 866536009017 putative active site [active] 866536009018 putative metal binding site [ion binding]; other site 866536009019 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 866536009020 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536009021 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 866536009022 active site 866536009023 metal binding site [ion binding]; metal-binding site 866536009024 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 866536009025 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 866536009026 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 866536009027 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 866536009028 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 866536009029 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 866536009030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866536009031 homodimer interface [polypeptide binding]; other site 866536009032 substrate-cofactor binding pocket; other site 866536009033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536009034 catalytic residue [active] 866536009035 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 866536009036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 866536009037 S-adenosylmethionine binding site [chemical binding]; other site 866536009038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 866536009039 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 866536009040 putative substrate binding site [chemical binding]; other site 866536009041 putative ATP binding site [chemical binding]; other site 866536009042 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 866536009043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536009044 putative substrate translocation pore; other site 866536009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536009046 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 866536009047 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 866536009048 substrate binding [chemical binding]; other site 866536009049 active site 866536009050 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 866536009051 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536009052 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 866536009053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 866536009054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 866536009055 dimerization interface [polypeptide binding]; other site 866536009056 GxxExxY protein; Region: GxxExxY; TIGR04256 866536009057 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 866536009058 active sites [active] 866536009059 tetramer interface [polypeptide binding]; other site 866536009060 imidazolonepropionase; Validated; Region: PRK09356 866536009061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536009062 active site 866536009063 urocanate hydratase; Provisional; Region: PRK05414 866536009064 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 866536009065 Fatty acid desaturase; Region: FA_desaturase; pfam00487 866536009066 Di-iron ligands [ion binding]; other site 866536009067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 866536009068 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 866536009069 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 866536009070 catalytic residues [active] 866536009071 dimer interface [polypeptide binding]; other site 866536009072 formimidoylglutamase; Provisional; Region: PRK13775 866536009073 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 866536009074 putative active site [active] 866536009075 putative metal binding site [ion binding]; other site 866536009076 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 866536009077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 866536009078 active site 866536009079 HIGH motif; other site 866536009080 nucleotide binding site [chemical binding]; other site 866536009081 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 866536009082 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 866536009083 active site 866536009084 KMSKS motif; other site 866536009085 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 866536009086 tRNA binding surface [nucleotide binding]; other site 866536009087 anticodon binding site; other site 866536009088 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 866536009089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536009090 salt bridge; other site 866536009091 non-specific DNA binding site [nucleotide binding]; other site 866536009092 sequence-specific DNA binding site [nucleotide binding]; other site 866536009093 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536009094 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 866536009095 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536009096 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 866536009097 FAD binding pocket [chemical binding]; other site 866536009098 conserved FAD binding motif [chemical binding]; other site 866536009099 phosphate binding motif [ion binding]; other site 866536009100 beta-alpha-beta structure motif; other site 866536009101 NAD binding pocket [chemical binding]; other site 866536009102 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 866536009103 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 866536009104 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 866536009105 oligomer interface [polypeptide binding]; other site 866536009106 active site 866536009107 metal binding site [ion binding]; metal-binding site 866536009108 Predicted permeases [General function prediction only]; Region: COG0730 866536009109 ATP-grasp domain; Region: ATP-grasp_4; cl17255 866536009110 Response regulator receiver domain; Region: Response_reg; pfam00072 866536009111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009112 active site 866536009113 phosphorylation site [posttranslational modification] 866536009114 intermolecular recognition site; other site 866536009115 dimerization interface [polypeptide binding]; other site 866536009116 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 866536009117 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 866536009118 active site 866536009119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 866536009120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009121 active site 866536009122 phosphorylation site [posttranslational modification] 866536009123 intermolecular recognition site; other site 866536009124 dimerization interface [polypeptide binding]; other site 866536009125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536009126 Walker A motif; other site 866536009127 ATP binding site [chemical binding]; other site 866536009128 Walker B motif; other site 866536009129 arginine finger; other site 866536009130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 866536009131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536009132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536009133 dimer interface [polypeptide binding]; other site 866536009134 phosphorylation site [posttranslational modification] 866536009135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536009136 ATP binding site [chemical binding]; other site 866536009137 Mg2+ binding site [ion binding]; other site 866536009138 G-X-G motif; other site 866536009139 Response regulator receiver domain; Region: Response_reg; pfam00072 866536009140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009141 active site 866536009142 phosphorylation site [posttranslational modification] 866536009143 intermolecular recognition site; other site 866536009144 dimerization interface [polypeptide binding]; other site 866536009145 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 866536009146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 866536009147 active site 866536009148 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 866536009149 SmpB-tmRNA interface; other site 866536009150 UGMP family protein; Validated; Region: PRK09604 866536009151 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 866536009152 Family of unknown function (DUF490); Region: DUF490; pfam04357 866536009153 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 866536009154 DNA photolyase; Region: DNA_photolyase; pfam00875 866536009155 Smr domain; Region: Smr; pfam01713 866536009156 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 866536009157 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 866536009158 homodimer interface [polypeptide binding]; other site 866536009159 substrate-cofactor binding pocket; other site 866536009160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536009161 catalytic residue [active] 866536009162 Uncharacterized conserved protein [Function unknown]; Region: COG0398 866536009163 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 866536009164 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 866536009165 active site 866536009166 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 866536009167 Predicted transcriptional regulators [Transcription]; Region: COG1695 866536009168 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 866536009169 PspC domain; Region: PspC; pfam04024 866536009170 PspC domain; Region: PspC; pfam04024 866536009171 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 866536009172 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 866536009173 Beta-Casp domain; Region: Beta-Casp; smart01027 866536009174 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 866536009175 HEPN domain; Region: HEPN; pfam05168 866536009176 Helix-turn-helix domain; Region: HTH_19; pfam12844 866536009177 non-specific DNA binding site [nucleotide binding]; other site 866536009178 salt bridge; other site 866536009179 sequence-specific DNA binding site [nucleotide binding]; other site 866536009180 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327 866536009181 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536009182 Helix-turn-helix domain; Region: HTH_19; pfam12844 866536009183 non-specific DNA binding site [nucleotide binding]; other site 866536009184 salt bridge; other site 866536009185 sequence-specific DNA binding site [nucleotide binding]; other site 866536009186 RloB-like protein; Region: RloB; pfam13707 866536009187 AAA domain; Region: AAA_21; pfam13304 866536009188 AAA domain; Region: AAA_21; pfam13304 866536009189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536009190 salt bridge; other site 866536009191 non-specific DNA binding site [nucleotide binding]; other site 866536009192 sequence-specific DNA binding site [nucleotide binding]; other site 866536009193 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 866536009194 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536009195 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 866536009196 HsdM N-terminal domain; Region: HsdM_N; pfam12161 866536009197 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 866536009198 Methyltransferase domain; Region: Methyltransf_26; pfam13659 866536009199 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 866536009200 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 866536009201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536009202 ATP binding site [chemical binding]; other site 866536009203 putative Mg++ binding site [ion binding]; other site 866536009204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 866536009205 nucleotide binding region [chemical binding]; other site 866536009206 ATP-binding site [chemical binding]; other site 866536009207 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 866536009208 Amidinotransferase; Region: Amidinotransf; pfam02274 866536009209 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 866536009210 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 866536009211 Sulfate transporter family; Region: Sulfate_transp; pfam00916 866536009212 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 866536009213 adenylosuccinate lyase; Provisional; Region: PRK09285 866536009214 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 866536009215 tetramer interface [polypeptide binding]; other site 866536009216 active site 866536009217 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 866536009218 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 866536009219 FAD binding pocket [chemical binding]; other site 866536009220 FAD binding motif [chemical binding]; other site 866536009221 phosphate binding motif [ion binding]; other site 866536009222 beta-alpha-beta structure motif; other site 866536009223 NAD(p) ribose binding residues [chemical binding]; other site 866536009224 NAD binding pocket [chemical binding]; other site 866536009225 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 866536009226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536009227 catalytic loop [active] 866536009228 iron binding site [ion binding]; other site 866536009229 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536009230 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536009231 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 866536009232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 866536009233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 866536009234 DNA binding residues [nucleotide binding] 866536009235 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 866536009236 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 866536009237 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 866536009238 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 866536009239 tRNA; other site 866536009240 putative tRNA binding site [nucleotide binding]; other site 866536009241 putative NADP binding site [chemical binding]; other site 866536009242 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 866536009243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866536009244 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 866536009245 putative active site [active] 866536009246 putative metal binding site [ion binding]; other site 866536009247 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 866536009248 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 866536009249 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 866536009250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009251 active site 866536009252 phosphorylation site [posttranslational modification] 866536009253 intermolecular recognition site; other site 866536009254 dimerization interface [polypeptide binding]; other site 866536009255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536009256 Walker A motif; other site 866536009257 ATP binding site [chemical binding]; other site 866536009258 Walker B motif; other site 866536009259 arginine finger; other site 866536009260 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 866536009261 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 866536009262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536009263 ATP binding site [chemical binding]; other site 866536009264 Mg2+ binding site [ion binding]; other site 866536009265 G-X-G motif; other site 866536009266 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866536009267 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 866536009268 putative active site [active] 866536009269 putative metal binding site [ion binding]; other site 866536009270 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 866536009271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 866536009272 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 866536009273 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 866536009274 RNA/DNA hybrid binding site [nucleotide binding]; other site 866536009275 active site 866536009276 DsrE/DsrF-like family; Region: DrsE; pfam02635 866536009277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 866536009278 non-specific DNA binding site [nucleotide binding]; other site 866536009279 salt bridge; other site 866536009280 sequence-specific DNA binding site [nucleotide binding]; other site 866536009281 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 866536009282 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 866536009283 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 866536009284 homodimer interface [polypeptide binding]; other site 866536009285 NADP binding site [chemical binding]; other site 866536009286 substrate binding site [chemical binding]; other site 866536009287 GTP-binding protein LepA; Provisional; Region: PRK05433 866536009288 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 866536009289 G1 box; other site 866536009290 putative GEF interaction site [polypeptide binding]; other site 866536009291 GTP/Mg2+ binding site [chemical binding]; other site 866536009292 Switch I region; other site 866536009293 G2 box; other site 866536009294 G3 box; other site 866536009295 Switch II region; other site 866536009296 G4 box; other site 866536009297 G5 box; other site 866536009298 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 866536009299 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 866536009300 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 866536009301 DNA helicase, putative; Region: TIGR00376 866536009302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 866536009303 ATP binding site [chemical binding]; other site 866536009304 putative Mg++ binding site [ion binding]; other site 866536009305 AAA domain; Region: AAA_12; pfam13087 866536009306 Protein of unknown function, DUF479; Region: DUF479; cl01203 866536009307 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 866536009308 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 866536009309 dimer interface [polypeptide binding]; other site 866536009310 substrate binding site [chemical binding]; other site 866536009311 metal binding sites [ion binding]; metal-binding site 866536009312 Response regulator receiver domain; Region: Response_reg; pfam00072 866536009313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009314 active site 866536009315 phosphorylation site [posttranslational modification] 866536009316 intermolecular recognition site; other site 866536009317 dimerization interface [polypeptide binding]; other site 866536009318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536009319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536009320 dimer interface [polypeptide binding]; other site 866536009321 phosphorylation site [posttranslational modification] 866536009322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536009323 ATP binding site [chemical binding]; other site 866536009324 Mg2+ binding site [ion binding]; other site 866536009325 G-X-G motif; other site 866536009326 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 866536009327 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 866536009328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536009329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 866536009330 dimer interface [polypeptide binding]; other site 866536009331 phosphorylation site [posttranslational modification] 866536009332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536009333 ATP binding site [chemical binding]; other site 866536009334 Mg2+ binding site [ion binding]; other site 866536009335 G-X-G motif; other site 866536009336 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 866536009337 ATP binding site [chemical binding]; other site 866536009338 substrate interface [chemical binding]; other site 866536009339 Response regulator receiver domain; Region: Response_reg; pfam00072 866536009340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009341 active site 866536009342 phosphorylation site [posttranslational modification] 866536009343 intermolecular recognition site; other site 866536009344 dimerization interface [polypeptide binding]; other site 866536009345 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 866536009346 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 866536009347 hexamer interface [polypeptide binding]; other site 866536009348 ligand binding site [chemical binding]; other site 866536009349 putative active site [active] 866536009350 NAD(P) binding site [chemical binding]; other site 866536009351 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 866536009352 Response regulator receiver domain; Region: Response_reg; pfam00072 866536009353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 866536009354 active site 866536009355 phosphorylation site [posttranslational modification] 866536009356 intermolecular recognition site; other site 866536009357 dimerization interface [polypeptide binding]; other site 866536009358 PglZ domain; Region: PglZ; pfam08665 866536009359 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 866536009360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 866536009361 Zn2+ binding site [ion binding]; other site 866536009362 Mg2+ binding site [ion binding]; other site 866536009363 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 866536009364 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 866536009365 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 866536009366 trimer interface [polypeptide binding]; other site 866536009367 active site 866536009368 UDP-GlcNAc binding site [chemical binding]; other site 866536009369 lipid binding site [chemical binding]; lipid-binding site 866536009370 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 866536009371 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 866536009372 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 866536009373 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 866536009374 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 866536009375 active site 866536009376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 866536009377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536009378 Walker A/P-loop; other site 866536009379 ATP binding site [chemical binding]; other site 866536009380 Q-loop/lid; other site 866536009381 ABC transporter signature motif; other site 866536009382 Walker B; other site 866536009383 D-loop; other site 866536009384 H-loop/switch region; other site 866536009385 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 866536009386 MutS domain III; Region: MutS_III; pfam05192 866536009387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 866536009388 Walker A/P-loop; other site 866536009389 ATP binding site [chemical binding]; other site 866536009390 Q-loop/lid; other site 866536009391 ABC transporter signature motif; other site 866536009392 Walker B; other site 866536009393 D-loop; other site 866536009394 H-loop/switch region; other site 866536009395 Smr domain; Region: Smr; pfam01713 866536009396 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 866536009397 Protein of unknown function DUF58; Region: DUF58; pfam01882 866536009398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 866536009399 metal ion-dependent adhesion site (MIDAS); other site 866536009400 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 866536009401 metal ion-dependent adhesion site (MIDAS); other site 866536009402 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 866536009403 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 866536009404 dimer interface [polypeptide binding]; other site 866536009405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536009406 catalytic residue [active] 866536009407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 866536009408 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 866536009409 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 866536009410 putative active site [active] 866536009411 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 866536009412 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 866536009413 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 866536009414 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 866536009415 Walker A/P-loop; other site 866536009416 ATP binding site [chemical binding]; other site 866536009417 Q-loop/lid; other site 866536009418 ABC transporter signature motif; other site 866536009419 Walker B; other site 866536009420 D-loop; other site 866536009421 H-loop/switch region; other site 866536009422 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 866536009423 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 866536009424 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 866536009425 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 866536009426 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 866536009427 protein binding site [polypeptide binding]; other site 866536009428 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 866536009429 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 866536009430 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 866536009431 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 866536009432 RIP metalloprotease RseP; Region: TIGR00054 866536009433 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 866536009434 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 866536009435 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 866536009436 putative substrate binding region [chemical binding]; other site 866536009437 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 866536009438 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 866536009439 Found in ATP-dependent protease La (LON); Region: LON; smart00464 866536009440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536009441 Walker A motif; other site 866536009442 ATP binding site [chemical binding]; other site 866536009443 Walker B motif; other site 866536009444 arginine finger; other site 866536009445 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 866536009446 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 866536009447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536009448 Walker A motif; other site 866536009449 ATP binding site [chemical binding]; other site 866536009450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 866536009451 Walker B motif; other site 866536009452 arginine finger; other site 866536009453 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 866536009454 short chain dehydrogenase; Provisional; Region: PRK06924 866536009455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 866536009456 NAD(P) binding site [chemical binding]; other site 866536009457 active site 866536009458 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 866536009459 catalytic core [active] 866536009460 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 866536009461 DNA-binding site [nucleotide binding]; DNA binding site 866536009462 RNA-binding motif; other site 866536009463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536009464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 866536009465 Amidohydrolase; Region: Amidohydro_4; pfam13147 866536009466 active site 866536009467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 866536009468 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 866536009469 metal binding triad; other site 866536009470 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 866536009471 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 866536009472 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 866536009473 HemN C-terminal domain; Region: HemN_C; pfam06969 866536009474 Family description; Region: DsbD_2; pfam13386 866536009475 FixH; Region: FixH; pfam05751 866536009476 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 866536009477 4Fe-4S binding domain; Region: Fer4_5; pfam12801 866536009478 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 866536009479 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 866536009480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 866536009481 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 866536009482 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 866536009483 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 866536009484 Low-spin heme binding site [chemical binding]; other site 866536009485 Putative water exit pathway; other site 866536009486 Binuclear center (active site) [active] 866536009487 Putative proton exit pathway; other site 866536009488 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 866536009489 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 866536009490 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 866536009491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 866536009492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 866536009493 Soluble P-type ATPase [General function prediction only]; Region: COG4087 866536009494 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536009495 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536009496 ligand binding site [chemical binding]; other site 866536009497 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 866536009498 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 866536009499 ligand binding site [chemical binding]; other site 866536009500 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 866536009501 Domain of unknown function DUF11; Region: DUF11; pfam01345 866536009502 Domain of unknown function DUF11; Region: DUF11; cl17728 866536009503 Domain of unknown function DUF11; Region: DUF11; cl17728 866536009504 Domain of unknown function DUF11; Region: DUF11; pfam01345 866536009505 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 866536009506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 866536009507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 866536009508 dimer interface [polypeptide binding]; other site 866536009509 phosphorylation site [posttranslational modification] 866536009510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 866536009511 ATP binding site [chemical binding]; other site 866536009512 Mg2+ binding site [ion binding]; other site 866536009513 G-X-G motif; other site 866536009514 Protein of unknown function (DUF420); Region: DUF420; pfam04238 866536009515 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 866536009516 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 866536009517 Cu(I) binding site [ion binding]; other site 866536009518 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 866536009519 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 866536009520 Subunit I/III interface [polypeptide binding]; other site 866536009521 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 866536009522 Subunit I/III interface [polypeptide binding]; other site 866536009523 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 866536009524 UbiA prenyltransferase family; Region: UbiA; pfam01040 866536009525 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 866536009526 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 866536009527 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 866536009528 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 866536009529 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 866536009530 ER lumen protein retaining receptor; Region: ER_lumen_recept; cl02155 866536009531 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 866536009532 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 866536009533 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 866536009534 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 866536009535 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 866536009536 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 866536009537 molybdopterin cofactor binding site; other site 866536009538 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 866536009539 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 866536009540 4Fe-4S binding domain; Region: Fer4_2; pfam12797 866536009541 cytochrome c-550; Provisional; Region: psbV; cl17239 866536009542 Cytochrome c; Region: Cytochrom_C; pfam00034 866536009543 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 866536009544 heme-binding residues [chemical binding]; other site 866536009545 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 866536009546 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536009547 catalytic loop [active] 866536009548 iron binding site [ion binding]; other site 866536009549 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 866536009550 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 866536009551 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536009552 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 866536009553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536009554 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 866536009555 translocation protein TolB; Provisional; Region: tolB; PRK03629 866536009556 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 866536009557 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 866536009558 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 866536009559 RNA binding site [nucleotide binding]; other site 866536009560 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 866536009561 RNA binding site [nucleotide binding]; other site 866536009562 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 866536009563 RNA binding site [nucleotide binding]; other site 866536009564 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866536009565 RNA binding site [nucleotide binding]; other site 866536009566 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866536009567 RNA binding site [nucleotide binding]; other site 866536009568 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 866536009569 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 866536009570 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 866536009571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 866536009572 putative acyl-acceptor binding pocket; other site 866536009573 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 866536009574 Cytochrome c; Region: Cytochrom_C; cl11414 866536009575 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 866536009576 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 866536009577 Metal-binding active site; metal-binding site 866536009578 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 866536009579 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 866536009580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 866536009581 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 866536009582 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 866536009583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 866536009584 putative substrate translocation pore; other site 866536009585 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 866536009586 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 866536009587 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 866536009588 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 866536009589 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 866536009590 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 866536009591 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 866536009592 ATP cone domain; Region: ATP-cone; pfam03477 866536009593 Class I ribonucleotide reductase; Region: RNR_I; cd01679 866536009594 active site 866536009595 dimer interface [polypeptide binding]; other site 866536009596 catalytic residues [active] 866536009597 effector binding site; other site 866536009598 R2 peptide binding site; other site 866536009599 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 866536009600 dimer interface [polypeptide binding]; other site 866536009601 putative radical transfer pathway; other site 866536009602 diiron center [ion binding]; other site 866536009603 tyrosyl radical; other site 866536009604 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 866536009605 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 866536009606 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 866536009607 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 866536009608 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 866536009609 Cna protein B-type domain; Region: Cna_B_2; pfam13715 866536009610 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 866536009611 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 866536009612 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 866536009613 starch binding outer membrane protein SusD; Region: SusD; cd08977 866536009614 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 866536009615 VPS10 domain; Region: VPS10; smart00602 866536009616 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 866536009617 30S subunit binding site; other site 866536009618 Rhomboid family; Region: Rhomboid; cl11446 866536009619 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 866536009620 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 866536009621 substrate binding pocket [chemical binding]; other site 866536009622 chain length determination region; other site 866536009623 substrate-Mg2+ binding site; other site 866536009624 catalytic residues [active] 866536009625 aspartate-rich region 1; other site 866536009626 active site lid residues [active] 866536009627 aspartate-rich region 2; other site 866536009628 ribonuclease R; Region: RNase_R; TIGR02063 866536009629 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 866536009630 RNB domain; Region: RNB; pfam00773 866536009631 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 866536009632 RNA binding site [nucleotide binding]; other site 866536009633 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 866536009634 active site 866536009635 catalytic site [active] 866536009636 substrate binding site [chemical binding]; other site 866536009637 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 866536009638 hypothetical protein; Reviewed; Region: PRK12497 866536009639 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 866536009640 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 866536009641 Walker A/P-loop; other site 866536009642 ATP binding site [chemical binding]; other site 866536009643 Q-loop/lid; other site 866536009644 ABC transporter signature motif; other site 866536009645 Walker B; other site 866536009646 D-loop; other site 866536009647 H-loop/switch region; other site 866536009648 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 866536009649 ABC-ATPase subunit interface; other site 866536009650 dimer interface [polypeptide binding]; other site 866536009651 putative PBP binding regions; other site 866536009652 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 866536009653 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 866536009654 putative ligand binding site [chemical binding]; other site 866536009655 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 866536009656 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 866536009657 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 866536009658 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 866536009659 Tetratricopeptide repeat; Region: TPR_16; pfam13432 866536009660 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 866536009661 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 866536009662 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 866536009663 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 866536009664 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 866536009665 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 866536009666 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 866536009667 C-N hydrolase family amidase; Provisional; Region: PRK10438 866536009668 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 866536009669 putative active site [active] 866536009670 catalytic triad [active] 866536009671 dimer interface [polypeptide binding]; other site 866536009672 multimer interface [polypeptide binding]; other site 866536009673 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 866536009674 active site 866536009675 catalytic residues [active] 866536009676 metal binding site [ion binding]; metal-binding site 866536009677 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 866536009678 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 866536009679 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 866536009680 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 866536009681 C-terminal peptidase (prc); Region: prc; TIGR00225 866536009682 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 866536009683 protein binding site [polypeptide binding]; other site 866536009684 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 866536009685 Catalytic dyad [active] 866536009686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 866536009687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 866536009688 dimer interface [polypeptide binding]; other site 866536009689 putative metal binding site [ion binding]; other site 866536009690 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 866536009691 Zn binding site [ion binding]; other site 866536009692 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 866536009693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 866536009694 N-terminal plug; other site 866536009695 ligand-binding site [chemical binding]; other site 866536009696 aldehyde dehydrogenase family 7 member; Region: PLN02315 866536009697 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 866536009698 tetrameric interface [polypeptide binding]; other site 866536009699 NAD binding site [chemical binding]; other site 866536009700 catalytic residues [active] 866536009701 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 866536009702 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 866536009703 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 866536009704 Transposase, Mutator family; Region: Transposase_mut; pfam00872 866536009705 MULE transposase domain; Region: MULE; pfam10551 866536009706 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 866536009707 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 866536009708 aspartate aminotransferase; Provisional; Region: PRK05764 866536009709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 866536009710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 866536009711 homodimer interface [polypeptide binding]; other site 866536009712 catalytic residue [active] 866536009713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 866536009714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 866536009715 MarR family; Region: MarR_2; pfam12802 866536009716 MarR family; Region: MarR_2; cl17246 866536009717 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 866536009718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 866536009719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 866536009720 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 866536009721 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 866536009722 catalytic loop [active] 866536009723 iron binding site [ion binding]; other site 866536009724 Domain of unknown function (DUF389); Region: DUF389; pfam04087 866536009725 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 866536009726 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 866536009727 active site 866536009728 substrate binding site [chemical binding]; other site 866536009729 coenzyme B12 binding site [chemical binding]; other site 866536009730 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 866536009731 B12 binding site [chemical binding]; other site 866536009732 cobalt ligand [ion binding]; other site 866536009733 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 866536009734 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 866536009735 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 866536009736 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 866536009737 active site 866536009738 metal binding site [ion binding]; metal-binding site